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GW24-e1287 Atorvastatin combined with captopril treatment in hypertensive hypercholesterolemic patients
- Source :
- Heart. 99:A241.2-A241
- Publication Year :
- 2013
- Publisher :
- BMJ, 2013.
-
Abstract
- Objectives This trial assessed the efficacy and vascular responses of combination therapy of statin with angiotensin-converting enzyme inhibitor in hypertensive hypercholesterolemic patients. Methods This was a randomised, double-blind, placebo-controlled study of atorvastatin alone, captopril alone and atorvastatin combined with captopril in 95 hypertensive hypercholesterolemic patients for 2 months with 2 months washout. Results Captopril alone did not significantly change C-reactive protein levels and lipoproteins, however, atorvastatin and atorvastatin combined with captopril significantly changed those, and atorvastatin combined with captopril showed significantly more improvement than captopril alone (P vs 6.2 ± 0.3 vs 10.2 ± 0.5, P vs 1.6 ± 0.2 vs 0.8 ± 0.01, P vs 167 ± 8 vs 127 ± 3, P vs 70 ± 5 vs 43 ± 6, P Conclusions Atorvastatin combined with captopril significantly improves endothelial function and reduces inflammatory markers in hypertensive hypercholesterolemic patients.
- Subjects :
- medicine.medical_specialty
Statin
Combination therapy
biology
medicine.drug_class
business.industry
Atorvastatin
Urology
nutritional and metabolic diseases
Washout
Captopril
Endocrinology
Enzyme inhibitor
Internal medicine
medicine
biology.protein
lipids (amino acids, peptides, and proteins)
cardiovascular diseases
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 1468201X and 13556037
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Heart
- Accession number :
- edsair.doi...........007f38260a00b3ecabc314b0cc6c4fb9