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SIMVASTATIN PREVENT RABBIT ARTERIAL ATHEROSCLEROSIS DEVELOPMENT THROUGH INTERFERING NUCLEAR FACTOR-κB ACTIVATION
- Source :
- Heart. 98:E93.1-E93
- Publication Year :
- 2012
- Publisher :
- BMJ, 2012.
-
Abstract
- Objectives To explore the effects of simvastatin on NF-κB activation in cholesterol diet rabbit artery and the underlying mechanisms of the beneficial effects of simvastatin on atherosclerosis (AS). Methods Twenty-four male rabbits were randomly divided into three groups: normal diet groups, cholesterol diet groups and the simvastatin groups which received both cholesterol diet and simvastatin 5 mg/kg/days intragastrically, After 16 weeks rabbits were executed and the aortas were harvested for the pathologic and morphologic observations. Western blot was used to determine cytoplasmic p-I-κB α, I-κB α protein expression and cytoplasmic and nuclear NF-κB p65 protein expression of rabbit aortas. Results Compared with normal diet groups, cholesterol diet groups demonstrated remarkably atherosclerosis in the arteries. And the expression of cytoplasmic p-I-κBа and nuclear NF-κB p65 expression was obviously increased, but I-κB α was markedly decreased in cholesterol diet groups (n=6; p Conclusions NF-κB activation might be involved in the process of atherosclerosis in high cholesterol diet rabbits. Simvastatin could ameliorates atherosclerosis (AS) through interfering NF-κB activation and translocation
- Subjects :
- medicine.medical_specialty
medicine.diagnostic_test
Normal diet
business.industry
Chromosomal translocation
Nuclear factor κb
Protein expression
Endocrinology
medicine.anatomical_structure
Western blot
Simvastatin
Internal medicine
medicine
lipids (amino acids, peptides, and proteins)
Cardiology and Cardiovascular Medicine
business
Beneficial effects
Artery
medicine.drug
Subjects
Details
- ISSN :
- 1468201X and 13556037
- Volume :
- 98
- Database :
- OpenAIRE
- Journal :
- Heart
- Accession number :
- edsair.doi...........4c43623bf8177987c9b92cd571c3bdc3