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Abstract Background To investigate the quantitative vascular and structural differences in the foveal region of the eyes in retinopathy of prematurity children with or without anti-vascular endothelial growth factor (VEGF) therapy and healthy children using optical coherence tomography angiography (OCTA). Methods This cross-sectional study analyzed 75 eyes from 44 subjects, categorized into four groups: ROP children treated with Conbercept or Ranibizumab, spontaneously regressed ROP, and healthy age-matched children. Using spectral-domain OCT and OCTA, we assessed parameters like central foveal thickness (CFT), foveal avascular zone (FAZ), superficial/deep capillary plexus (SCP/DCP), and choroidal vessel density (VD) at the fovea. Correlations between foveal microvasculature, preterm status and visual acuity were evaluated. Results Significant differences were found in FAZ area, CFT, and VD-SCP (parafoveal) among the groups. The FAZ area was smaller in ROP children (with/without treatment) than in healthy counterparts(p = 0.009). CFT was higher in the Ranibizumab and spontaneously regressed groups compared to healthy ones (p = 0.043, p = 0.037), while Conbercept-treated children showed no significant difference (p = 0.886). Foveal VD trends were higher in groups A, B, and C compared to group D. FAZ area correlated negatively with CFT, VD-SCP (foveal), and VD-DCP (foveal) (p

Abstract Histopathological examination holds a crucial role in cancer grading and serves as a significant reference for devising individualized patient treatment plans in clinical practice. Nevertheless, the distinctive features of numerous histopathological image targets frequently contribute to suboptimal segmentation performance. In this paper, we propose a UNet-based multi-scale context fusion algorithm for medical image segmentation, which extracts rich contextual information by extracting semantic information at different encoding stages and assigns different weights to the semantic information at different scales through TBSFF module to improve the learning ability of the network for features. Through multi-scale context fusion and feature selection networks, richer semantic features and detailed information are extracted. The target can be more accurately segmented without significantly increasing the extra overhead. The results demonstrate that our algorithm achieves superior Dice and IoU scores with a relatively small parameter count. Specifically, on the GlaS dataset, the Dice score is 90.56, and IoU is 83.47. For the MoNuSeg dataset, the Dice score is 79.07, and IoU is 65.98.

Abstract Orthodontic relapse (OR) occurs at a rate of over 70%. Retention is the current attempt at prevention, but it requires a considerable amount of time and cannot fully block OR. It’s imperative to find a safe and effective method for managing post-orthodontic tooth stability. Periodontal bone remodeling is one crucial biological foundation of OR. Mesenchymal stem cell-derived exosomes (MSC-Exo) show promise in relapse management by regulating periodontal bone remodeling. MSC-Exo can prevent relapse by regulating periodontal ligament function, osteoclast activity, osteoblast differentiation, macrophage polarization, and periodontal microcirculation. In recent years, exosome-loaded hydrogels, which achieve controlled exosome release, have demonstrated efficacy in promoting bone regeneration and remodeling, offering promising prospects for OR management. This review aims to highlight the use of MSC-Exo-based therapy for preventing OR, offering new insights for future research focused on improving tooth stability and enhancing orthodontic anchorage.

During the process of bilateral teleoperation, operators not only need to perform complex maintenance tasks but also have to constantly monitor the safety of the operation, leading to reduced operational efficiency. Therefore, in this paper, we introduce a shared autonomous scheme that intervenes in the operator's command input when necessary, autonomously ensuring the safe operation of the manipulator by employing a rolling horizon planning controller based on Nonlinear Model Predictive Control (NMPC). This controller considers the motion boundaries and collision avoidance constraints of the manipulator, accompanied by the design of corresponding objective functions. To validate the effectiveness of the proposed method, we conduct tests on collision-free trajectory tracking and comprehensive performance with collision constraints, confirming the feasibility and excellent performance of the approach.

The CFETR multipurpose overload robot (CMOR) is a critical component of the fusion reactor remote handling system. To accurately calculate and visualize the structural deformation and stress characteristics of the CMOR motion process, this paper first establishes a CMOR kinematic model to analyze the unfolding and working process in the vacuum chamber. Then, the dynamic model of CMOR is established using the Lagrangian method, and the rigid-flexible coupling modeling of CMOR links and joints is achieved using the finite element method and the linear spring damping equivalent model. The co-simulation results of the CMOR rigid-flexible coupled model show that when the end load is 2000 kg, the extreme value of the end-effector position error is more than 0.12 m, and the maximum stress value is 1.85 × 108 Pa. To utilize the stress-strain data of CMOR, this paper designs a CMOR morphology prediction control system based on Unity software. Implanting CMOR finite element analysis data into the Unity environment, researchers can monitor the stress strain generated by different motion trajectories of the CMOR robotic arm in the control system. It provides a platform for subsequent research on CMOR error compensation and extreme operation warnings.

Abstract Background Capsule endoscopy (CE) is useful for managing patients with suspected small bowel diseases. However, the effect of prolonged CE examination time on CE performance is unknown. Aim To evaluate the completeness and diagnostic yield of prolonged CE imaging in patients with suspected small bowel bleeding. Methods We reviewed consecutive records of adult CE examinations via an overnight protocol from Jan 2016 to Dec 2020 at a tertiary center in Taiwan. We subcategorized the CE records by recording length into within 8 h, within 12 h and throughout the whole procedure and compared the completion rate and diagnostic yield between the groups. Cochran’s Q test was used for statistical analysis. Results A total of 88 patients were enrolled with 78.4% inpatients (median age 72 years). The small bowel evaluation completion rate was 93.2%, which was significantly greater than the 79.5% rate within 12 h (p = 0.025) and the 58% rate within 8 h (p

Abstract This article delves into Alzheimer’s disease (AD), a prevalent neurodegenerative condition primarily affecting the elderly. It is characterized by progressive memory and cognitive impairments, severely disrupting daily life. Recent research highlights the potential involvement of microRNAs in the pathogenesis of AD. MicroRNAs (MiRNAs), short non-coding RNAs comprising 20–24 nucleotides, significantly influence gene regulation by hindering translation or promoting degradation of target genes. This review explores the role of specific miRNAs in AD progression, focusing on their impact on β-amyloid (Aβ) peptide accumulation, intracellular aggregation of hyperphosphorylated tau proteins, mitochondrial dysfunction, neuroinflammation, oxidative stress, and the expression of the APOE4 gene. Our insights contribute to understanding AD’s pathology, offering new avenues for identifying diagnostic markers and developing novel therapeutic targets.

Abstract Objective Subcortical nuclei such as the thalamus and striatum have been shown to be related to seizure modulation and termination, especially in drug‐resistant epilepsy. Enhance diffusion‐weighted imaging (eDWI) technique and tri‐component model have been used in previous studies to calculate apparent diffusion coefficient from ultra high b‐values (ADCuh). This study aimed to explore the alterations of ADCuh in the bilateral thalamus and striatum in MRI‐negative drug‐resistant epilepsy. Methods Twenty‐nine patients with MRI‐negative drug‐resistant epilepsy and 18 healthy controls underwent eDWI scan with 15 b‐values (0–5000 s/mm2). The eDWI parameters including standard ADC (ADCst), pure water diffusion (D), and ADCuh were calculated from the 15 b‐values. Regions‐of‐interest (ROIs) analyses were conducted in the bilateral thalamus, caudate nucleus, putamen, and globus pallidus. ADCst, D, and ADCuh values were compared between the MRI‐negative drug‐resistant epilepsy patients and controls using multivariate generalized linear models. Inter‐rater reliability was assessed using the intra‐class correlation coefficient (ICC) and Bland–Altman (BA) analysis. False discovery rate (FDR) method was applied for multiple comparisons correction. Results ADCuh values in the bilateral thalamus, caudate nucleus, putamen, and globus pallidus in MRI‐negative drug‐resistant epilepsy were significantly higher than those in the healthy control subjects (all p

Abstract Purpose This current study attempted to investigate whether one-stitch method (OM) of temporary ileostomy influenced the stoma-related complications after laparoscopic low anterior resection (LLAR). Methods We searched for eligible studies in four databases including PubMed, Embase, Cochrane Library, and CNKI from inception to July 20, 2023. Both surgical outcomes and stoma-related complications were compared between the OM group and the traditional method (TM) group. The Newcastle–Ottawa Scale (NOS) was adopted for quality assessment. RevMan 5.4 was conducted for data analyzing. Results Totally 590 patients from six studies were enrolled in this study (272 patients in the OM group and 318 patients in the TM group). No significant difference was found in baseline information (P > 0.05). Patients in the OM group had shorter operative time in both the primary LLAR surgery (MD = − 17.73, 95%CI = − 25.65 to − 9.80, P

Abstract Electronic band structures in hydrogenated graphene are theoretically investigated by means of first-principle calculations and an effective tight-binding model. It is shown that regularly designed hydrogenation to graphene gives rise to a large band gap about 1 eV. Remarkably, by changing the spatial pattern of the hydrogenation, topologically distinct states can be realized, where the topological nontriviality is detected by $$C_2$$ C 2 parity indices in bulk and confirmed by the existence of gapless edge/interface states as protected by the mirror and sublattice symmetries. The analysis of the wave functions reveals that the helical edge states in hydrogenated graphene with the appropriate design carry pseudospin currents that are reminiscent of the quantum spin Hall effect. Our work shows the potential of hydrogenated graphene in pseudospin-based device applications.

Abstract Objectives To use T1ρ mapping to assess myocardial fibrosis and to provide a reference for future clinical application, it is necessary to understand the factors influencing T1ρ values. This study explored the influence of different spin-locking frequencies on T1ρ values under a 3.0-T MR system. Methods Fifty-seven healthy subjects were prospectively and consecutively included in this study, and T1ρ mapping was performed on them in 3 short-axis slices with three spin-lock frequencies at the amplitude of 300 Hz, 400 Hz, and 500 Hz, then nine T1ρ images were acquired per subject. Four T1ρ-weighted images were acquired using a spin-lock preparation pulse with varying durations (0 msec, 13.3 msec, 26.6 msec, 40 msec). T1ρ relaxation times were quantified for each slice and each myocardial segment. The results were analyzed using Student’s t-test and one-way analysis of variance (ANOVA) methods. Results Mean T1ρ relaxation times were 43.5 ± 2.8 msec at 300 Hz, 44.9 ± 3.6 msec at 400 Hz, and 46.2 ± 3.1 msec at 500 Hz, showing a significant progressive increase from low to high spin-lock frequency (300 Hz vs. 400 Hz, p = 0.046; 300 Hz vs. 500 Hz, p

Abstract Background Increasing evidence suggests that leptin is involved in the pathology of autism spectrum disorder (ASD). In this study, our objective was to investigate the levels of leptin in the blood of children with ASD and to examine the overall profile of adipokine markers in ASD through meta-analysis. Methods Leptin concentrations were measured using an enzyme-linked immunosorbent assay (ELISA) kit, while adipokine profiling, including leptin, was performed via meta-analysis. Original reports that included measurements of peripheral adipokines in ASD patients and healthy controls (HCs) were collected from databases such as Web of Science, PubMed, and Cochrane Library. These studies were collected from September 2022 to September 2023 and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Standardized mean differences were calculated using a random effects model for the meta-analysis. Additionally, we performed meta-regression and explored heterogeneity among studies. Results Our findings revealed a significant increase in leptin levels in children with ASD compared to HCs (p = 0.0319). This result was consistent with the findings obtained from the meta-analysis (p

Halobenzoquinones (HBQs) are ubiquitous disinfection by-products (DBPs) in chlorinated drinking water with various health risks including reproductive toxicity, while the potential mechanisms are still unclear. Although green tea exhibits common detoxifying properties, its ability to mitigate the toxicity of HBQs still needs to be further deepened and explored. This study attempted to investigate the possible mechanism of the most common HBQ, 2,6-dichloro-1,4-benzoquinone (2,6-DCBQ) induced reproductive toxicity and elucidate the protective effect of green tea using a series of liquid chromatography-tandem mass spectrometry (LC-MS) approaches. Firstly, in vivo experiments showed that 2,6-DCBQ could induce testicular damage in male rats via significantly decreasing sperm-associated Leydig cells and seminiferous tubules. Then, in vitro incubation of 2,6-DCBQ with amino acids suggested that 2,6-DCBQ could bind to proteins via residues of cysteine or lysine and provided five additional modification patterns. Following, proteomics analysis revealed that at least 42 proteins were modified by 2,6-DCBQ, which were mainly enriched in the reproductive system. These results highlighted the significance of covalent protein modification in 2,6-DCBQ reproductive toxicity. Fortunately, we found that catechins (a class of major components of green tea) could competitively bind to 2,6-DCBQ in vivo and in vitro, reducing the amount and type of 2,6-DCBQ-protein adducts, thereby attenuating the reproductive system damage caused by 2,6-DCBQ. This study provides new insights into 2,6-DCBQ-induced reproductive system damage and reveals a new mechanism of green tea detoxification. Moreover, these findings offer potential strategies for alleviating the harmful impacts of environmental toxicants on human health.

Multi-point ignition by high-frequency nanosecond surface dielectric barrier discharge (nSDBD) offers the potential to enhance the combustion speed of NH3/air mixtures. This paper investigates the ignition process of high-frequency nSDBD in NH3/air mixture. Firstly, the morphology of the discharge channels is studied, and it is found that before the formation of a clear flame kernel, with the increase of the pulse number, the discharge filament length increases first and then stabilized, while the discharge filament number decreases from about 20 to around 12. Secondly, the influence of the mixed gas state on discharge characteristics is studied, and it is observed that as the gas pressure increases, the single pulse energy decreases and the discharge filament length decreases, but the deposition energy per unit length did not change significantly. The increase in NH3 concentration leads to a slight decrease in discharge energy and length. Finally, the effect of the flame kernel on discharge morphology is studied, and it is found that when the flame kernel is small, the discharge filament trees change from dispersed to coincident, and the discharge energy is concentrated. When the flame kernel is large, the discharge filament trees mostly transform into overlapping types, and the number decreases.

Heart failure with preserved ejection fraction (HFpEF), a complex disease that is increasingly prevalent due to population aging, pose significant challenges in its treatment. The present study utilized the HFpEF rat model and H9C2 cells as research subjects to thoroughly investigate the potential mechanisms of alarin in protecting cardiac function in HFpEF. The study shows that under HFpEF conditions, oxidative stress significantly increases, leading to myocardial structural damage and dysfunction of calcium ion channels, which ultimately impairs diastolic function. Alarin, through its interaction with NADPH oxidase 1 (NOX1), effectively alleviates oxidative stress and modulates the activities of type 2 ryanodine receptor (RyR2) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2), thereby facilitating the restoration of Ca2+ homeostasis and significantly improving cardiac function in the HFpEF model. This research not only uncovers the cardioprotective effects of alarin and its underlying molecular mechanisms but also provides new insights and potential therapeutic targets for HFpEF treatment strategies, suggesting a promising future for alarin and related therapies in the management of this debilitating condition.

Background Mature rapeseed pods typically shatter when harvested, resulting in approximately 8–12% yield loss. Adverse weather conditions and mechanized harvesting can diminish pod yield by up to 50%, primarily owing to delays in harvesting and mechanical collisions. The pod shatter resistance index (PSRI) assesses pod damage. Recent research focused on comparing pod shatter resistance among varieties, evaluating methods, and studying gene knockout mechanisms. However, there remains a pressing need to broaden the scope of research. In particular, it is essential to recognize that pod shatter, a complex trait, influenced by genetics, environment, agronomic practices, and harvest techniques. Future studies should integrate these factors to develop comprehensive strategies to mitigate pod shatter, enhancing rapeseed yields and agricultural mechanization. This review explores factors affecting pod shatter resistance and strategies to improve it. Methodology Scoping literature review that adhered to the methodological framework for systematic reviews was performed using search engines such as Google Scholar, Web of Science, and the Chinese National Knowledge Infrastructure. This review aimed to identify pertinent articles, which were subsequently subjected to thorough screening and evaluation. The protocol for this literature review involved the following key steps: definition of research questions, development of a search strategy, development of data extraction strategy, synthesis of the extracted data, and organization and analysis of the extracted data. Results The review presents strategies for enhancing rapeseed yield during mechanized harvesting, focusing on four key areas: (i) selecting and breeding shatter-resistant varieties using DNA markers to establish a robust germplasm resource; (ii) optimizing cultivation technologies and agronomic measures to elicit favorable interactions between compact plant-type genotypes and the environment, thereby facilitating nutrient-related regulatory mechanisms of rapeseed pods to improve pod dry weight and resistance; (iii) innovating combine header design and structure to better suit rapeseed harvesting; and (iv) providing training for operators to enhance their harvesting skills. These comprehensive measures aim to minimize yield loss, increase production efficiency. Conclusion To effectively reduce yield loss during mechanized harvesting of rapeseed, it is crucial to enhance resistance to pod shattering by addressing both internal physiological factors and external environmental conditions. This requires a holistic approach that includes genetic improvements, optimization of ecological conditions, careful cultivation management, and precise harvesting timing, along with ongoing research into traits related to machine harvesting to boost production efficiency and sustainability.

The impact-echo (IE) method is effective for evaluating invisible defects. However, it might return misleading results when its signals are invalid. This challenge aggravates when the tests are conducted using robotic devices that automatically collect massive data. This study proposes an automatic method to eliminate invalid signals based on the ResNet model. First, the signals are visualized into two-dimensional images as the input for ResNet. The input data can then be classified into valid and invalid data via the ResNet model, which is trained with 11,290 signals and tested with 5664 signals. Finally, defects can be detected using the dominant frequencies of the valid-class data. A case study with IE data from two concrete bridges was employed to validate the feasibility of the proposed approach. The results indicate that the method can achieve an average accuracy of 90.6% for eliminating invalid signals and significantly improve the IE test accuracy.

Abstract Schizophrenia (SCZ), which affects approximately 1% of the world’s population, is a global public health concern. It is generally considered that the interplay between genes and the environment is important in the onset and/or development of SCZ. Although several whole-exome sequencing studies have revealed rare risk variants of SCZ, no rare coding variants have been strongly replicated. Assessing isolated populations under extreme conditions might lead to the discovery of variants with a recent origin, which are more likely to have a higher frequency than chance to reflect gene-environment interactions. Following this approach, we examined a unique cohort of Tibetans living at an average altitude above 4500 meters. Whole-exome sequencing of 47 SCZ cases and 53 controls revealed 275 potential novel risk variants and two known variants (12:46244485: A/G and 22:18905934: A/G) associated with SCZ that were found in existing databases. Only one gene (C5orf42) in the gene-based statistics surpassed the exome-wide significance in the cohort. Metascape enrichment analysis suggested that novel risk genes were strongly enriched in pathways relevant to hypoxia, neurodevelopment, and neurotransmission. Additionally, 47 new risk genes were followed up in Han sample of 279 patients with SCZ and 95 controls, only BAI2 variant appearing in one case. Our findings suggest that SCZ patients living at high altitudes may have a unique risk gene signature, which may provide additional information on the underlying biology of SCZ, which can be exploited to identify individuals at greater risk of exposure to hypoxia.

Mature wheat kernels contain three main parts: endosperm, bran, and germ. Flour milling results in multiple streams that are chemically different; however, the distribution of antioxidants and phenolic compounds has not been well documented in terms of conventional milling by-product streams. In this study, multiple analytical methods were used to investigate antioxidant activity and phenolic compound compositions of hard red winter wheat (whole ground wheat), the parts of a wheat kernel (bran, flour, germ), and wheat by-product streams (mill feed, red dog, shorts) for the first time. For each mill stream, phenolic compounds (total, flavonoid, and anthocyanin contents) were determined and antioxidant activities were evaluated with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity, ferric reducing/antioxidant power (FRAP), and total antioxidant capacity assays. Significant differences (P

Abstract High-altitude cerebral edema (HACE) is a severe neurological condition that can occur at high altitudes. It is characterized by the accumulation of fluid in the brain, leading to a range of symptoms, including severe headache, confusion, loss of coordination, and even coma and death. Exosomes play a crucial role in intercellular communication, and their contents have been found to change in various diseases. This study analyzed the metabolomic characteristics of blood exosomes from HACE patients compared to those from healthy controls (HCs) with the aim of identifying specific metabolites or metabolic pathways associated with the development of HACE conditions. A total of 21 HACE patients and 21 healthy controls were recruited for this study. Comprehensive metabolomic profiling of the serum exosome samples was conducted using ultraperformance liquid chromatography–tandem mass spectrometry (UPLC‒MS/MS). Additionally, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis was performed to identify the metabolic pathways affected in HACE patients. Twenty-six metabolites, including ( +)-camphoric acid, choline, adenosine, adenosine 5′-monophosphate, deoxyguanosine 5′-monophosphate, guanosine, and hypoxanthine-9-β-D-arabinofuranoside, among others, exhibited significant changes in expression in HACE patients compared to HCs. Additionally, these differentially abundant metabolites were confirmed to be potential biomarkers for HACE. KEGG pathway enrichment analysis revealed several pathways that significantly affect energy metabolism regulation (such as purine metabolism, thermogenesis, and nucleotide metabolism), estrogen-related pathways (the estrogen signaling pathway, GnRH signaling pathway, and GnRH pathway), cyclic nucleotide signaling pathways (the cGMP-PKG signaling pathway and cAMP signaling pathway), and hormone synthesis and secretion pathways (renin secretion, parathyroid hormone synthesis, secretion and action, and aldosterone synthesis and secretion). In patients with HACE, adenosine, guanosine, and hypoxanthine-9-β-D-arabinofuranoside were negatively correlated with height. Deoxyguanosine 5′-monophosphate is negatively correlated with weight and BMI. Additionally, LPE (18:2/0:0) and pregnanetriol were positively correlated with age. This study identified potential biomarkers for HACE and provided valuable insights into the underlying metabolic mechanisms of this disease. These findings may lead to potential targets for early diagnosis and therapeutic intervention in HACE patients.

Abstract Various studies have focused on the application of fibrin sealants (FS) in thyroid surgery. Utilizing a meta-analysis, this systematic review analyzed the findings of recent randomized controlled trials on the safety and efficacy of FS in patients who underwent thyroidectomy. The Cochrane Library, Web of Science, Embase, PubMed, and Medline databases were searched for relevant studies, without any language restrictions. Seven randomized controlled trials were included in the originally identified 69 studies. Overall, 652 patients received FS during thyroid surgery; their outcomes were compared with those of conventionally treated patients. The primary outcomes were total volume of wound drainage, length of hospitalization, and operative time. Significant differences were observed in the total volume of wound drainage (mean deviation (MD): -29.75, 95% confidence interval (CI): -55.39 to -4.11, P = 0.02), length of hospitalization (MD: -0.84, 95% CI: -1.02 to -0.66, P

Abstract The miniaturised wideband filter with good frequency selectivity and wide stopband is proposed, which is based on three‐dimensional (3D) heterogeneous integrated passive device technology. The proposed sixth‐order wideband bandpass filter is based on the magnetic‐coupling‐loaded highpass‐lowpass lumped topology and implemented by the 3D heterogeneous integration process, integrating GaAs‐based and Glass‐based micro‐nano‐scale processes together. Then, lumped inductors are designed in the Glass substrate with low dielectric loss tangent and realised by a three‐dimensional spiral structure. Therefore, the inductors have high quality factors and small sizes. The lumped capacitors are designed using the GaAs thin film process. Finally, a prototype with a 3‐dB fractional bandwidth of 42% is designed and fabricated at 3.875 GHz (f0). The upper‐stopband attenuation higher than 30 dB is extended to more than 5.15f0. It occupies only 0.014 × 0.018 λ02 (1.1 × 1.42 mm2), where λ0 is the free‐space wavelength at f0.

Abstract A miniaturised high‐isolation K‐/Ka‐band diplexer with exceeding adjacent channels using 3D antarafacial channel integration and vertical‐quasi‐coaxial‐based matching network is proposed. For smaller size, lower loss and lower channel interference, the high‐order low‐pass filter for the K‐band channel and the four‐line‐interdigital‐coupled wideband bandpass filter for the Ka‐band channel are respectively designed on two low‐loss glass‐based substrates, and these two substrates are integrated on the two antarafacial surface of the mounting board. The vertical‐quasi‐coaxial (VQC) embedded in the mounting board is not only used as three‐dimensional (3D) interconnection of the two antarafacial channels but also designed as the constituent part of the matching/isolation network, and this can effectively decrease the impedance traction caused by the Ka‐band filter for the K‐band channel of the diplexer. In addition, four transmission zeros of the K‐band filter are designed at the whole passband of the Ka‐band channel to improve the isolation to the K‐band channel for guaranteeing the performance of the diplexer at the Ka‐band channel. Furthermore, working principle, design method and test solution of this proposed K‐/Ka‐band diplexer are well illustrated, and the high‐isolation (>40 dB) in very adjacent wideband channels at K‐band (18–23.5 GHz) and Ka‐band (25.8–31.6 GHz) is achieved within a tiny size of 9 × 4 × 0.87 mm.

Bacterial infections remain a significant global health concern, necessitating a comprehensive understanding of the intricate host−pathogen interactions that play a critical role in the outcome of infectious diseases. Recent investigations have revealed that noncoding RNAs (ncRNAs) are key regulators of these complex interactions. Among them, long noncoding RNAs (lncRNAs) have gained significant attention because of their diverse regulatory roles in gene expression, cellular processes and the production of cytokines and chemokines in response to bacterial infections. The host utilizes lncRNAs as a defense mechanism to limit microbial pathogen invasion and replication. On the other hand, some host lncRNAs contribute to the establishment and maintenance of bacterial pathogen reservoirs within the host by promoting bacterial pathogen survival, replication, and dissemination. However, our understanding of host lncRNAs in the context of bacterial infections remains limited. This review focuses on the impact of host lncRNAs in shaping host−pathogen interactions, shedding light on their multifaceted functions in both host defense and bacterial survival, and paving the way for future research aimed at harnessing their regulatory potential for clinical applications.

This study presents a novel cost-effective Fe30Ni25Cr25Mo10Al10 high-entropy alloy with a dual-phase microstructure that was processed using cyclic closed-die forging (CCDF) at room temperature for a maximum of six passes. The as-homogenized alloy exhibited [CrMoFe]-rich dendrites with dual-size morphology dispersed in an almost uniform face-centered cubic (FCC) matrix. It was found that as the number of CCDF passes increased, leading to a more homogenous nanograin, there was an accumulation of dislocations, fragmentation of [CrMoFe]-rich dendrites, and enhanced distribution within the matrix. These conditions were conducive to the creation of a nanostructured Fe30Ni25Cr25Mo10Al10 alloy with superior mechanical properties. Texture analysis indicated that the prominent texture components for the Fe30Ni25Cr25Mo10Al10 alloy after six passes were Rotated Cube {001}, S {123}, and Dillamore {4 4 11}. After the sixth CCDF pass, the Fe30Ni25Cr25Mo10Al10 alloy exhibited the highest microhardness (∼ 974 HV) and the lowest wear rate (∼ (0.8 ± 0.1) × 10–5 mm3.N−1.m−1). Additionally, it was proposed that the development of the Rotated Cube {001} texture component contributed positively to enhancing wear resistance in the cost-effective high-entropy alloys. Considering the obtained results, it is reasonable to propose that CCDF processing is significant potential for the advancement of cost-effective nanostructured high-entropy alloys for industrial applications.

The present study assesses the impact of age hardening parameters, including aging temperature, aging time, and solution time, on the ultimate hardness of heat-treated 2024 aluminum alloys. Using a numerical approach, fuzzy logic systems were utilized as a robust tool to forecast the mechanical characteristics of high copper aluminum solid solutions throughout the age hardening process. In addition, an attempt was made to use a novel simulated annealing technique to determine the optimum hardness and its corresponding process parameters to achieve the highest mechanical properties. Comparing a fuzzy logic model with experimental results obtained from the Brinell hardness test showed the accuracy and confidence of the fuzzy model in representing such properties. The optimization results indicated that the maximum hardness can be obtained with a solution aging temperature of 173.5 °C, an aging time of 19 hours, and a solution time of 58 minutes. Overall, the variation in the experimental peak hardness obtained using the optimized process parameters was the deciding factor in believing the model.

Abstract Here, based on thin film integrated passive device (TF‐IPD) technology, compact ultra‐wideband (UWB) bandpass filter (BPF) and dual‐band bandpass filter (DBBPF) with equal inductance configuration are proposed. The configuration of equal inductance in a circuit contributes to reducing variables, simplifying the physical structure, and shortening the debugging time in the TF‐IPD design process. Despite all the inductors being equal in value, a wide passband can still be achieved. The measured results show that the centre frequency of UBW BPF is 11.43 GHz, and the 3‐dB fractional bandwidth (FBW) is 133% (3.87–18.99 GHz). And the 3‐dB FBWs of DBBPF centred at 6.5 GHz and 16.2 GHz are 92% (3.51–9.49 GHz) and 35% (13.33–18.98 GHz), respectively. The stopband of UBW BPF and DBBPF can be extended to 47.7 GHz and 44.8 GHz in sizes of 321 µm × 856 µm and 235 µm × 846 µm, respectively (excluding measuring pads).

IntroductionSiraitia grosvenorii (Swingle) C. Jeffrey, is an edible and traditional medicine widely used in China. Mogroside V (MGV) and mogrol (MG) are its main active ingredients, which have been found to be effective in the treatment of neurodegenerative diseases recently. However, whether they can effectively treat Parkinson’s disease (PD) and their underlying mechanisms have not been sufficiently explored. In this study, we investigated the neuroprotective and metabolic regulatory effects of MGV and MG on PD.Materials and methodsUsing SH-SY5Y cell models and an MPTP-induced mouse model of PD, we evaluated the compounds’ efficacy in mitigating MPP+-induced neurotoxicity and ameliorating motor deficits and dopaminergic neuron loss. Employing widely targeted metabolomics and bioinformatics analysis to investigate the Metabolic imbalance rectification caused by MGV and MG treatment. The vivo experimental protocol encompassed a 14-day drug administration regimen with mice randomly allocated into six groups (n = 9) receiving distinct compound dosages including a control group, a model group, MGV-H (30 mg/kg/day), MGV-L (10 mg/kg/day), MG-H (15 mg/kg/day), and MG-L (3 mg/kg/day).ResultsOur findings revealed that pre-treatment with MGV and MG significantly enhanced cell viability in SH-SY5Y cells exposed to MPP+, demonstrating a potent protective effect against neurotoxicity. In the MPTP mouse model, MGV-H, MGV-L, and MG-H significantly enhanced motor coordination as assessed by the rotarod test (p < 0.05); MGV-L and MG-H evidently inhibited dopaminergic neuronal loss in the substantia nigra pars compacta (p < 0.05). Furthermore, metabolomic analysis of the substantia nigra highlighted the restoration of metabolic balance, with MGV-L and MG-H impacting 160 differential metabolites and modulating key pathways disrupted in PD, including sphingolipid metabolism, fatty acid metabolism, and amino acid metabolism. Notably, treatment with MGV-L and MG-H led to the regulation of 106 metabolites, showing a recovery trend towards normal levels, which constitutes approximately 17.5% of the identified metabolites. Key metabolites such as n-acetyl-l-glutamate, hexadecanoic acid, and 9-octadecenal were significantly altered (p < 0.05), underscoring their broad-spectrum metabolic regulatory capacity.ConclusionThis study underscores the potential of natural compounds in developing comprehensive treatment strategies for neurodegenerative diseases, paving the way for future clinical research to validate the therapeutic efficacy of mogrosides in PD.