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MicroRNAs: pioneering regulators in Alzheimer’s disease pathogenesis, diagnosis, and therapy
- Source :
- Translational Psychiatry, Vol 14, Iss 1, Pp 1-15 (2024)
- Publication Year :
- 2024
- Publisher :
- Nature Publishing Group, 2024.
-
Abstract
- Abstract This article delves into Alzheimer’s disease (AD), a prevalent neurodegenerative condition primarily affecting the elderly. It is characterized by progressive memory and cognitive impairments, severely disrupting daily life. Recent research highlights the potential involvement of microRNAs in the pathogenesis of AD. MicroRNAs (MiRNAs), short non-coding RNAs comprising 20–24 nucleotides, significantly influence gene regulation by hindering translation or promoting degradation of target genes. This review explores the role of specific miRNAs in AD progression, focusing on their impact on β-amyloid (Aβ) peptide accumulation, intracellular aggregation of hyperphosphorylated tau proteins, mitochondrial dysfunction, neuroinflammation, oxidative stress, and the expression of the APOE4 gene. Our insights contribute to understanding AD’s pathology, offering new avenues for identifying diagnostic markers and developing novel therapeutic targets.
- Subjects :
- Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Subjects
Details
- Language :
- English
- ISSN :
- 21583188
- Volume :
- 14
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Translational Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.751f5116df604067b3235ad1b2346ef2
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41398-024-03075-8