1. The impact of combined pulmonary fibrosis and emphysema on mortality
- Author
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Changhoon Lee, Yang Sc, Kim Dk, Yeon Jh, Lee Jy, Kim Yw, Yoo Cg, Heesun Chung, Seung Sik Hwang, Lee Sm, Kim Dj, Lim Ky, Kim Hj, Park Cm, Shim Ys, Yim Jj, and Han Sk
- Subjects
Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,Vital capacity ,Time Factors ,Pulmonary Fibrosis ,Comorbidity ,Kaplan-Meier Estimate ,Risk Assessment ,Hospitals, University ,Risk Factors ,Internal medicine ,Neoplasms ,Pulmonary fibrosis ,Republic of Korea ,medicine ,Humans ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Aged, 80 and over ,Chi-Square Distribution ,business.industry ,Proportional hazards model ,Case-control study ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Prognosis ,Combined pulmonary fibrosis and emphysema ,Infectious Diseases ,Pulmonary Emphysema ,Case-Control Studies ,Female ,business ,Tomography, X-Ray Computed ,Chi-squared distribution - Abstract
Setting The impact on patient mortality of combined pulmonary fibrosis and emphysema (CPFE) compared with emphysema alone has never been investigated. Objective To elucidate whether CPFE has an impact on overall mortality over that of emphysema alone. Design We screened patients who underwent chest computed tomography (CT) scans during the period from 1 January 2001 to 31 December 2005 in a tertiary referral hospital. Patients who had both emphysema and pulmonary fibrosis, thus meeting the inclusion criteria, were defined as CPFE. Controls with emphysema alone who were matched for age, sex and the date of CT scan were randomly selected. Cox proportional regression analysis was performed to verify whether CPFE is associated with increased overall mortality. Results We found 135 CPFE cases. In the multivariable Cox regression stratified by the presence of comorbid malignancy, CPFE had five times higher mortality risk (adjusted HR 5.10, 95%CI 1.75-14.9) in non-malignant cases, and showed a statistically insignificant trend for higher mortality risk (adjusted HR 1.70, 95%CI 0.94-2.51) in the malignant cases after adjusting for forced vital capacity, height and hypertension. Conclusion CPFE is not rare and CPFE patients had a higher overall mortality risk than emphysema-only patients.
- Published
- 2011