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5. Supplementary information from Balancing Efficacy and Safety of an Anti-DLL4 Antibody through Pharmacokinetic Modulation

Author

Couch, Jessica A., primary, Zhang, Gu, primary, Beyer, Joseph C., primary, de Zafra, Christina L. Zuch, primary, Gupta, Priyanka, primary, Kamath, Amrita V., primary, Lewin-Koh, Nicholas, primary, Tarrant, Jacqueline, primary, Allamneni, Krishna P., primary, Cain, Gary, primary, Yee, Sharon, primary, Ross, Sarajane, primary, Cook, Ryan, primary, Tsai, Siao Ping, primary, Ruppel, Jane, primary, Ridgway, John Brady, primary, Paluch, Maciej, primary, Hass, Philip E., primary, Franklin, Jayme, primary, and Yan, Minhong, primary

Published
2023
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7. Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands

Author

Chung, Jooho, Ebens, Christen L., Perkey, Eric, Radojcic, Vedran, Koch, Ute, Scarpellino, Leonardo, Tong, Alexander, Allen, Frederick, Wood, Sherri, Feng, Jiane, Friedman, Ann, Granadier, David, Tran, Ivy T., Chai, Qian, Onder, Lucas, Yan, Minhong, Reddy, Pavan, Blazar, Bruce R., Huang, Alex Y., Brennan, Todd V., Bishop, D. Keith, Ludewig, Burkhard, Siebel, Christian W., Radtke, Freddy, Luther, Sanjiv A., and Maillard, Ivan

Subjects
Graft vs. host disease -- Genetic aspects -- Development and progression -- Care and treatment, Cellular signal transduction -- Genetic aspects -- Health aspects, Signaling peptides and proteins -- Health aspects, Health care industry
Abstract

Alloimmune T cell responses induce graft-versus-host disease (GVHD), a serious complication of allogeneic bone marrow transplantation (allo-BMT). Although Notch signaling mediated by Delta-like 1/4 (DLL1/4) Notch ligands has emerged as a major regulator of GVHD pathogenesis, little is known about the timing of essential Notch signals and the cellular source of Notch ligands after allo-BMT. Here, we have shown that critical DLL1/4-mediated Notch signals are delivered to donor T cells during a short 48-hour window after transplantation in a mouse allo-BMT model. Stromal, but not hematopoietic, cells were the essential source of Notch ligands during in vivo priming of alloreactive T cells. GVHD could be prevented by selective inactivation of Dll1 and Dll4 in subsets of fibroblastic stromal cells that were derived from chemokine Ccl19-expressing host cells, including fibroblastic reticular cells and follicular dendritic cells. However, neither T cell recruitment into secondary lymphoid organs nor initial T cell activation was affected by Dll1/4 loss. Thus, we have uncovered a pathogenic function for fibroblastic stromal cells in alloimmune reactivity that can be dissociated from their homeostatic functions. Our results reveal what we believe to be a previously unrecognized Notch-mediated immunopathogenic role for stromal cell niches in secondary lymphoid organs after allo-BMT and define a framework of early cellular and molecular interactions that regulate T cell alloimmunity., Introduction Allogeneic bone marrow transplantation (allo-BMT) can cure hematological malignancies and other blood disorders. However, alloimmune T cell responses arising against foreign tissue antigens can trigger major complications such as [...]

Published
2017
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8. Direct Tie2 Agonists Stabilize Vasculature for the Treatment of Diabetic Macular Edema

Author

Agard, Nicholas J., primary, Zhang, Gu, additional, Ridgeway, John, additional, Dicara, Danielle M., additional, Chu, Phillip Y., additional, Ohri, Rachana, additional, Sanowar, Sarah, additional, Vernes, Jean-Michel, additional, Chi, Hannah, additional, Zhang, Jiameng, additional, Holz, Emily, additional, Paluch, Maciej, additional, He, Guannan, additional, Benson, Yingjia, additional, Zhang, Jianhuan, additional, Chan, Pamela, additional, Tang, Nga, additional, Javale, Prachi, additional, Wilson, Blair, additional, Barrett, Kathy, additional, Rowntree, Rebecca K., additional, Hang, Julie, additional, Meng, Y. Gloria, additional, Hass, Phil, additional, Fuh, Germaine, additional, Piskol, Robert, additional, Bantseev, Vladimir, additional, Loyet, Kelly M., additional, Tran, John C., additional, Wu, Cong, additional, Indjeian, Vahan B., additional, Shivva, Vittal, additional, and Yan, Minhong, additional

Published
2022
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9. PEGylation of anti-MerTK Antibody Modulates Ocular Biodistribution

Author

Vollmar, Breanna S., primary, Fei, Mingjian, additional, Liang, Wei-Ching, additional, Bravo, Daniel D., additional, Wang, Joy, additional, Yu, Lanlan, additional, Corr, Nick, additional, Zhang, Gu, additional, McNamara, Erin, additional, Masih, Shabkhaiz, additional, Chee, Elin, additional, Shin, Gawon, additional, Ohri, Rachana, additional, Leipold, Douglas D., additional, Wu, Cong, additional, Dere, Edward, additional, Wang, Jianyong, additional, Huang, Haochu, additional, Wu, Yan, additional, and Yan, Minhong, additional

Published
2022
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10. Inhibition of Endothelial Notch Signaling Impairs Fatty Acid Transport and Leads to Metabolic and Vascular Remodeling of the Adult Heart

Author

Jabs, Markus, Rose, Adam J., Lehmann, Lorenz H., Taylor, Jacqueline, Moll, Iris, Sijmonsma, Tjeerd P., Herberich, Stefanie E., Sauer, Sven W., Poschet, Gernot, Federico, Giuseppina, Mogler, Carolin, Weis, Eva-Maria, Augustin, Hellmut G., Yan, Minhong, Gretz, Norbert, Schmid, Roland M., Adams, Ralf H., Gröne, Hermann-Joseph, Hell, Rüdiger, Okun, Jürgen G., Backs, Johannes, Nawroth, Peter P., Herzig, Stephan, and Fischer, Andreas

Published
2018
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12. CLEC5a-directed bispecific antibody for effective cellular phagocytosis

Author

Kedage, Vivekananda, primary, Ellerman, Diego, additional, Fei, Mingjian, additional, Liang, Wei-Ching, additional, Zhang, Gu, additional, Cheng, Eric, additional, Zhang, Juan, additional, Chen, Yongmei, additional, Huang, Haochu, additional, Lee, Wyne P., additional, Wu, Yan, additional, and Yan, Minhong, additional

Published
2022
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15. Blockade of individual Notch ligands and receptors controls graft-versus-host disease

Author

Tran, Ivy T., Sandy, Ashley R., Carulli, Alexis J., Ebens, Christen, Chung, Jooho, Shan, Gloria T., Radojcic, Vedran, Friedman, Ann, Gridley, Thomas, Shelton, Amy, Reddy, Pavan, Samuelson, Linda C., Yan, Minhong, Siebel, Christian W., and Maillard, Ivan

Subjects
T cells -- Research -- Physiological aspects, Bone marrow -- Transplantation, Graft versus host reaction -- Risk factors -- Prevention, Proteins -- Research -- Physiological aspects, Health care industry
Abstract

Graft-versus-host disease (GVHD) is the main complication of allogeneic bone marrow transplantation. Current strategies to control GVHD rely on global immunosuppression. These strategies are incompletely effective and decrease the anticancer [...]

Published
2013
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16. Therapeutic antibody targeting of individual Notch receptors

Author

Wu, Yan, Cain-Hom, Carol, Choy, Lisa, Hagenbeek, Thijs J., de Leon, Gladys P., Chen, Yongmei, Finkle, David, Venook, Rayna, Wu, Xiumin, Ridgway, John, Schahin-Reed, Dorreyah, Dow, Graham J., Shelton, Amy, Stawicki, Scott, Watts, Ryan J., Zhang, Jeff, Choy, Robert, Howard, Peter, Kadyk, Lisa, Yan, Minhong, Zha, Jiping, Callahan, Christopher A., Hymowitz, Sarah G., and Siebel, Christian W.

Subjects
Proteases -- Physiological aspects, Proteolysis -- Research, Viral antibodies -- Properties, Membrane proteins -- Properties, Antibodies -- Properties, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The four receptors of the Notch family are widely expressed transmembrane proteins that function as key conduits through which mammalian cells communicate to regulate cell fate and growth (1,2). Ligand binding triggers a conformational change in the receptor negative regulatory region (NRR) that enables ADAM protease cleavage (3,4) at a juxtamembrane site that otherwise lies buried within the quiescent NRR (5,6). Subsequent intramembrane proteolysis catalysed by the y-secretase complex liberates the intracellular domain (ICD) to initiate the downstream Notch transcriptional program. Aberrant signalling through each receptor has been linked to numerous diseases, particularly cancer (7), making the Notch pathway a compelling target for new drugs. Although y-secretase inhibitors (GSIs) have progressed into the clinic (8), GSIs fail to distinguish individual Notch receptors, inhibit other signalling pathways (9) and cause intestinal toxicity (10), attributed to dual inhibition of Notch1 and 2 (ref. 11). To elucidate the discrete functions of Notch1 and Notch2 and develop clinically relevant inhibitors that reduce intestinal toxicity, we used phage display technology to generate highly specialized antibodies that specifically antagonize each receptor paralogue and yet cross-react with the human and mouse sequences, enabling the discrimination of Notch1 versus Notch2 function in human patients and rodent models. Our co-crystal structure shows that the inhibitory mechanism relies on stabilizing NRR quiescence. Selective blocking of Notch1 inhibits tumour growth in pre-clinical models through two mechanisms: inhibition of cancer cell growth and deregulation of angiogenesis. Whereas inhibition of Notch1 plus Notch2 causes severe intestinal toxicity, inhibition of either receptor alone reduces or avoids this effect, demonstrating a clear advantage over pan-Notch inhibitors. Our studies emphasize the value of paralogue-specific antagonists in dissecting the contributions of distinct Notch receptors to differentiation and disease and reveal the therapeutic promise in targeting Notch1 and Notch2 independently., To enable independent antagonism of Notchl and Notch2, we used phage display to generate antibodies targeting the NRRs. Previous studies proposed that antibody targeting of the NRR might stabilize the [...]

Published
2010
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17. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

Author

Ridgway, John, Zhang, Gu, Wu, Yan, Stawicki, Scott, Liang, Wei-Ching, Chanthery, Yvan, Kowalski, Joe, Watts, Ryan J., Callahan, Christopher, Kasman, Ian, Singh, Mallika, Chien, May, Tan, Christine, Hongo, Jo-Anne S., de Sauvage, Fred, Plowman, Greg, and Yan, Minhong

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): John Ridgway [1, 5]; Gu Zhang [1, 5]; Yan Wu [2, 5]; Scott Stawicki [2]; Wei-Ching Liang [2]; Yvan Chanthery [1]; Joe Kowalski [1]; Ryan J. Watts [1]; Christopher [...]

Published
2006
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18. Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

Author

Zhou, Yi, primary, Fei, Mingjian, additional, Zhang, Gu, additional, Liang, Wei-Ching, additional, Lin, WeiYu, additional, Wu, Yan, additional, Piskol, Robert, additional, Ridgway, John, additional, McNamara, Erin, additional, Huang, Haochu, additional, Zhang, Juan, additional, Oh, Jaehak, additional, Patel, Jaina M., additional, Jakubiak, Diana, additional, Lau, Jeff, additional, Blackwood, Beth, additional, Bravo, Daniel D., additional, Shi, Yongchang, additional, Wang, Jianyong, additional, Hu, Hong-Ming, additional, Lee, Wyne P., additional, Jesudason, Rajiv, additional, Sangaraju, Dewakar, additional, Modrusan, Zora, additional, Anderson, Keith R., additional, Warming, Søren, additional, Roose-Girma, Merone, additional, and Yan, Minhong, additional

Published
2020
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19. Targeted IgMs agonize ocular targets with extended vitreal exposure

Author

Chen, Yvonne, primary, Paluch, Maciej, additional, Zorn, Julie A., additional, Rajan, Sharmila, additional, Leonard, Brandon, additional, Estevez, Alberto, additional, Brady, John, additional, Chiu, Henry, additional, Phung, Wilson, additional, Famili, Amin, additional, Yan, Minhong, additional, Ciferri, Claudio, additional, Matsumoto, Marissa L., additional, Lazar, Greg A., additional, Crowell, Susan, additional, Hass, Phil, additional, and Agard, Nicholas J., additional

Published
2020
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23. Rapid Development of Glaucoma Via ITV Nonselective ANGPT 1/2 Antibody: A Potential Role for ANGPT/TIE2 Signaling in Primate Aqueous Humor Outflow

Author

Thackaberry, Evan A., primary, Zhou, Yi, additional, Zuch de Zafra, Christina L., additional, Fuh, Germaine, additional, Lee, Chingwei V., additional, Sanowar, Sarah, additional, Ridgway, John B., additional, Kusi, Aija M., additional, Farman, Cindy, additional, Booler, Helen, additional, Sheinson, Daniel, additional, Rasmussen, Carol A., additional, Miller, Paul E., additional, Wakshull, Eric, additional, Yan, Minhong, additional, and Bantseev, Vladimir, additional

Published
2019
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25. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

Author

Yan, Minhong, Dai, Tianang, Deak, Joseph C., Kyriakis, John M., Zon, Leonard I., Woodgett, James R., and Templeton, Dennis J.

Subjects
Protein kinases -- Research, Stress (Physiology) -- Influence, Phosphorylation -- Analysis, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Analysis of NIH3T3 cell sublines expressing MEK kinase-1 (MEKK) shows that MEKK induction activates the stress-activated protein kinases (SAPKs). A new signalling cascade is regulated by MEKK upon phosphorylation of the SAPK activator, SEK1, which phosphorylates and stimulates SAPK. MEKK is similar to kinases mediating yeast mating signal cascades and is involved in vitro MEK activation.

Published
1994

26. Corrigendum: Notch signal strength controls cell fate in the haemogenic endothelium

Author

Gama-Norton, Leonor, Ferrando, Eva, Ruiz-Herguido, Cristina, Liu, Zhenyi, Guiu, Jordi, Islam, Abul B. M. M. K., Lee, Sung-Uk, Yan, Minhong, Guidos, Cynthia J., López-Bigas, Nuria, Maeda, Takahiro, Espinosa, Lluis, Kopan, Raphael, and Bigas, Anna

Subjects
Receptors, Notch, Calcium-Binding Proteins, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Arteries, Hematopoietic Stem Cells, Corrigenda, Mice, Inbred C57BL, Animals, Intercellular Signaling Peptides and Proteins, Female, Serrate-Jagged Proteins, Endothelium, Vascular, Aorta, Jagged-1 Protein, Adaptor Proteins, Signal Transducing
Abstract

Acquisition of the arterial and haemogenic endothelium fates concurrently occur in the aorta-gonad-mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation. The arterial programme depends on Dll4 and the haemogenic endothelium/HSC on Jag1-mediated Notch1 signalling. How Notch1 distinguishes and executes these different programmes in response to particular ligands is poorly understood. By using two Notch1 activation trap mouse models with different sensitivity, here we show that arterial endothelial cells and HSCs originate from distinct precursors, characterized by different Notch1 signal strengths. Microarray analysis on AGM subpopulations demonstrates that the Jag1 ligand stimulates low Notch strength, inhibits the endothelial programme and is permissive for HSC specification. In the absence of Jag1, endothelial cells experience high Dll4-induced Notch activity and select the endothelial programme, thus precluding HSC formation. Interference with the Dll4 signal by ligand-specific blocking antibodies is sufficient to inhibit the endothelial programme and favour specification of the haematopoietic lineage.

Published
2016

29. Notch Signaling Mediated By Dll1/4 Notch Ligands Controls the Pathogenesis of Both Multi-Organ System Non-Sclerodermatous and Sclerodermatous Chronic Graft-Versus-Host Disease

Author

Radojcic, Vedran, primary, Flynn, Ryan P, additional, Chung, Jooho, additional, Du, Jing, additional, Perkey, Eric, additional, Paz, Katelyn, additional, Zaiken, Michael, additional, Friedman, Ann, additional, Yan, Minhong, additional, Siebel, Christian W., additional, Blazar, Bruce R., additional, and Maillard, Ivan, additional

Published
2016
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30. PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia

Author

Ola, Roxana, primary, Dubrac, Alexandre, additional, Han, Jinah, additional, Zhang, Feng, additional, Fang, Jennifer S., additional, Larrivée, Bruno, additional, Lee, Monica, additional, Urarte, Ana A., additional, Kraehling, Jan R., additional, Genet, Gael, additional, Hirschi, Karen K., additional, Sessa, William C., additional, Canals, Francesc V., additional, Graupera, Mariona, additional, Yan, Minhong, additional, Young, Lawrence H., additional, Oh, Paul S., additional, and Eichmann, Anne, additional

Published
2016
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31. BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site

Author

Gordon, Nathaniel C., Pan, Borlan, Hymowitz, Sarah G., Yin, JianPing, Kelley, Robert F., Cochran, Andrea G., Yan, Minhong, Dixit, Vishva M., Fairbrother, Wayne J., and Starovasnik, Melissa A.

Subjects
Proteins, Ligand binding (Biochemistry) -- Analysis, Protein binding -- Analysis, Structure-activity relationships (Biochemistry) -- Analysis, Tumor necrosis factor, Biological sciences, Chemistry
Abstract

Research describes the solution structure of BR3 extracellular domain of the BAFF protein involved in the signal transduction during B cell function. Data indicate that a core region consisting of 19 residues exhibits a stable structure, stabilized by noncanonical disulfide bond. Furthemore, BR3 possesses BAFF binding sites and it binds to BAFF via a highly focused ligand-binding site.

Published
2003

32. Zn-based metal–organic framework with intramolecular hydrogen bond for the electroreduction of CO2 to formate.

Author

Yan, Minhong, Yang, Ying, Zhan, Tingting, Luo, Jiayi, Huang, Limei, Ma, Xiuling, and Xiang, Shengchang

Abstract

Metal–organic frameworks (MOFs) have important research value in the field of electrochemical CO2 reduction reaction because of their rational design. Here, a new MOF-CH3 was prepared via a simple solvothermal method by using Zn as the metal center and 1,2,4-triazole and 2-methyl-terephthalic acid as ligands for electrocatalytic CO2 reduction. The single-crystal X-ray diffraction shows that MOF-CH3 is N, O-coordinated 3D columnar layer framework with intramolecular hydrogen-bonding interactions. The powder X-ray diffraction for MOF-CH3 displays the good crystallinity of 24 h in 0.5 mol L−1 KHCO3 electrolyte solution. The electrochemical CO2 reduction reaction tests indicate that the MOF could effectively convert CO2 to formate, and the highest Faradaic efficiency of formate (FEformate) is 76.5% at − 1.37 V (vs. reversible hydrogen electrode) with a partial current density of formate of − 12.1 mA cm−2. The performance of MOF-CH3 is better than that of the reported other two structural analogues MOF-NH2 with FEformate of 55.7% at − 1.57 V or MOF-H with FEformate of 73.5% at − 1.37 V in aqueous CO2-saturated electrolyte solution. The work shows that the performance could be improved by regulating the microenvironment of MOF catalysts. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Balancing Efficacy and Safety of an Anti-DLL4 Antibody through Pharmacokinetic Modulation

Author

Couch, Jessica A., primary, Zhang, Gu, additional, Beyer, Joseph C., additional, de Zafra, Christina L. Zuch, additional, Gupta, Priyanka, additional, Kamath, Amrita V., additional, Lewin-Koh, Nicholas, additional, Tarrant, Jacqueline, additional, Allamneni, Krishna P., additional, Cain, Gary, additional, Yee, Sharon, additional, Ross, Sarajane, additional, Cook, Ryan, additional, Tsai, Siao Ping, additional, Ruppel, Jane, additional, Ridgway, John Brady, additional, Paluch, Maciej, additional, Hass, Philip E., additional, Franklin, Jayme, additional, and Yan, Minhong, additional

Published
2016
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34. Notch signal strength controls cell fate in the haemogenic endothelium

Author

Gama-Norton, Leonor, primary, Ferrando, Eva, additional, Ruiz-Herguido, Cristina, additional, Liu, Zhenyi, additional, Guiu, Jordi, additional, Islam, Abul B. M. M. K., additional, Lee, Sung-Uk, additional, Yan, Minhong, additional, Guidos, Cynthia J., additional, López-Bigas, Nuria, additional, Maeda, Takahiro, additional, Espinosa, Lluis, additional, Kopan, Raphael, additional, and Bigas, Anna, additional

Published
2015
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35. Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention

Author

Wang, Weihuan, primary, Yu, Shuiliang, additional, Zimmerman, Grant, additional, Wang, Yiwei, additional, Myers, Jay, additional, Yu, Vionnie W. C., additional, Huang, Dan, additional, Huang, Xiaoran, additional, Shim, Jeongsup, additional, Huang, Yuanshuai, additional, Xin, William, additional, Qiao, Peter, additional, Yan, Minhong, additional, Xin, Wei, additional, Scadden, David T., additional, Stanley, Pamela, additional, Lowe, John B., additional, Huang, Alex Y., additional, Siebel, Christian W., additional, and Zhou, Lan, additional

Published
2015
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37. Transient Blockade of Delta-like Notch Ligands Prevents Allograft Rejection Mediated by Cellular and Humoral Mechanisms in a Mouse Model of Heart Transplantation

Author

Wood, Sherri, primary, Feng, Jiane, additional, Chung, Jooho, additional, Radojcic, Vedran, additional, Sandy-Sloat, Ashley R., additional, Friedman, Ann, additional, Shelton, Amy, additional, Yan, Minhong, additional, Siebel, Christian W., additional, Bishop, D. Keith, additional, and Maillard, Ivan, additional

Published
2015
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38. Loss of Notch Receptor-Ligand Engagement Leads to Increased Hematopoietic Stem and Progenitor Cell Egress and Mobilization

Author

Zhou, Lan, primary, Wang, Weihuan, additional, Zimmerman, Grant, additional, Myers, Jay, additional, Huang, Yuanshuai, additional, Yu, Vionnie W.C., additional, Huang, Dan, additional, Yu, Shuiliang, additional, Wang, Yiwei, additional, Huang, Xiaoran, additional, Shim, Jeongsup, additional, Yan, Minhong, additional, Lowe, John, additional, Xin, Wei, additional, Stanley, Pamela, additional, Scadden, David T., additional, Huang, Alex Y, additional, and Siebel, Christian W., additional

Published
2014
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39. Delta-like Ligands Expressed By Stromal Cells in Secondary Lymphoid Organs Deliver an Early Pulse of Notch Signaling and Drive T Cell Pathogenicity in Acute Graft-Versus-Host Disease

Author

Chung, Jooho, primary, Ebens, Christen L., additional, Radojcic, Vedran, additional, Koch, Ute, additional, Friedman, Ann, additional, Tran, Ivy T., additional, Chai, Qian, additional, Onder, Lucas, additional, Yan, Minhong, additional, Reddy, Pavan, additional, Blazar, Bruce R., additional, Ludewig, Burkhard, additional, Siebel, Christian W., additional, Radtke, Freddy, additional, and Maillard, Ivan, additional

Published
2014
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40. Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice

Author

Kamath, Amrita V, primary, Yip, Victor, additional, Gupta, Priyanka, additional, Boswell, C Andrew, additional, Bumbaca, Daniela, additional, Haughney, Peter, additional, Castro, Joni, additional, Tsai, Siao Ping, additional, Pacheco, Glenn, additional, Ross, Sarajane, additional, Yan, Minhong, additional, Damico-Beyer, Lisa A, additional, Khawli, Leslie, additional, and Shen, Ben-Quan, additional

Published
2014
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41. Delta-Like Notch Ligands Expressed By Host Non-Hematopoietic Radioresistant Cells Regulate Graft-Versus-Host Disease and Extrathymic T Cell Development After Bone Marrow Transplantation

Author

Ebens, Christen L, primary, Chung, Jooho, additional, Koch, Ute, additional, Tran, Ivy T, additional, Sandy-Sloat, Ashley R, additional, Friedman, Ann, additional, Blazar, Bruce R, additional, Reddy, Pavan, additional, Yan, Minhong, additional, Siebel, Christian W, additional, Radtke, Freddy, additional, and Maillard, Ivan, additional

Published
2013
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42. LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance

Author

Lee, Sung-Uk, primary, Maeda, Manami, additional, Ishikawa, Yuichi, additional, Li, Sierra Min, additional, Wilson, Anne, additional, Jubb, Adrian M., additional, Sakurai, Nagisa, additional, Weng, Lihong, additional, Fiorini, Emma, additional, Radtke, Freddy, additional, Yan, Minhong, additional, MacDonald, H. Robson, additional, Chen, Ching-Cheng, additional, and Maeda, Takahiro, additional

Published
2013
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44. In Vivo Blockade of Individual Notch Ligands and Receptors Provides a New Targeted Therapeutic Approach In Graft-Versus-Host Disease

Author

Tran, Ivy T, primary, Sandy, Ashley R, additional, Carulli, Alexis, additional, Shan, Gloria T, additional, Radojcic, Vedran, additional, Friedman, Ann, additional, Shelton, Amy, additional, Samuelson, Linda C, additional, Yan, Minhong, additional, Siebel, Christian W, additional, and Maillard, Ivan, additional

Published
2011
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45. LRF Maintains HSC Homeostasis by Preventing Lymphoid-Primed LT-HSCs From Excessive Differentiation

Author

Lee, Sung-Uk, primary, Maeda, Manami, additional, Wilson, Anne E., additional, Li, Min, additional, Ishikawa, Yuichi, additional, Judd, Adrian M., additional, Sakurai, Nagisa, additional, Fiorini, Emma, additional, Radtke, Freddy, additional, Yan, Minhong, additional, Macdonald, Hugh Robson, additional, Chen, Ching-Cheng, additional, and Maeda, Takahiro, additional

Published
2011
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50. Structures of APRIL-Receptor Complexes

Author

Hymowitz, Sarah G., primary, Patel, Darshana R., additional, Wallweber, Heidi J.A., additional, Runyon, Steven, additional, Yan, Minhong, additional, Yin, JianPing, additional, Shriver, Stephanie K., additional, Gordon, Nathaniel C., additional, Pan, Borlan, additional, Skelton, Nicholas J., additional, Kelley, Robert F., additional, and Starovasnik, Melissa A., additional

Published
2005
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