BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site

Research describes the solution structure of BR3 extracellular domain of the BAFF protein involved in the signal transduction during B cell function. Data indicate that a core region consisting of 19 residues exhibits a stable structure, stabilized by noncanonical disulfide bond. Furthemore, BR3 possesses BAFF binding sites and it binds to BAFF via a highly focused ligand-binding site.