Blockade of individual Notch ligands and receptors controls graft-versus-host disease

Authors :: Tran, Ivy T.
Sandy, Ashley R.
Carulli, Alexis J.
Ebens, Christen
Chung, Jooho
Shan, Gloria T.
Radojcic, Vedran
Friedman, Ann
Gridley, Thomas
Shelton, Amy
Reddy, Pavan
Samuelson, Linda C.
Yan, Minhong
Siebel, Christian W.
Maillard, Ivan
Source :: Journal of Clinical Investigation. April 1, 2013, Vol. 123 Issue 4, p1590, 15 p.
Publication Year :: 2013
Abstract: Graft-versus-host disease (GVHD) is the main complication of allogeneic bone marrow transplantation. Current strategies to control GVHD rely on global immunosuppression. These strategies are incompletely effective and decrease the anticancer [...]

Subjects :: T cells -- Research -- Physiological aspects
Bone marrow -- Transplantation
Graft versus host reaction -- Risk factors -- Prevention
Proteins -- Research -- Physiological aspects
Health care industry

Full Text Access

Tools