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A recent study conducted at Jiangnan University in Wuxi, People's Republic of China, utilized a combination of machine learning and quantum chemistry to accelerate the identification of antioxidant peptides (AOPs) and analyze their structure-activity relationships. The study introduced a Bi-LSTM-based model, AOPP, which outperformed existing methods in accuracy and precision. Experimental validation confirmed the antioxidant activity of ten peptides, with LLA showing the highest scavenging rates. The research highlights the potential of machine learning and quantum chemistry in efficiently discovering AOPs with applications in therapeutics and functional foods. [Extracted from the article]

A study conducted at Jiangnan University in Wuxi, People's Republic of China, explored the use of sulforaphane (SFN) in protecting against membranous nephropathy (MN) by inhibiting oxidative stress-associated podocyte pyroptosis. The research found that SFN had a protective effect on MN by alleviating nephrotic syndrome, improving podocyte foot process fusion, and reducing oxidative stress markers. The study concluded that SFN could alleviate MN by inhibiting oxidative stress-associated podocyte pyroptosis. [Extracted from the article]

A study conducted at Jiangnan University in Wuxi, China, focused on how interaction quality in digital museums influences users' psychological responses and their intention to continue using these platforms. The research integrated the Stimulus-Organism-Response model and telepresence theory to analyze 414 valid responses from visitors to the China Zisha-ware Digital Museum. The findings revealed that interaction quality and users' psychological responses significantly impact users' intention to continue using digital museums, with telepresence mediating this relationship. The study provides insights for enhancing user experience design in digital museums to promote cultural dissemination and educational efforts. [Extracted from the article]

Researchers at Jiangnan University in Wuxi, China, have developed a new type of nanocomposite film using polybutylene adipate terephthalate (PBAT) combined with tannic acid-zinc oxide (TA-ZnO) nanoparticles. The TA-ZnO-CTAB particles showed antimicrobial properties against E. coli and S. aureus, as well as antioxidant activity. The resulting PBAT/TA-ZnO-CTAB composite films exhibited excellent UV shielding effects, antioxidant, and antibacterial activities, making them promising materials for active food packaging. This study highlights the potential of nanotechnology in enhancing the functionality of biodegradable polymers for food packaging applications. [Extracted from the article]

A study conducted by Jiangnan University in Wuxi, China, explored the effects of different ratios of A-type (AS) and B-type (BS) wheat starch on the quality of liangpi, a starch gel food. The research found that a higher AS/BS ratio resulted in increased hardness, resilience, and chewiness in liangpi. Additionally, sensory scores were higher for AS-dominated liangpi, with 60% AS yielding the highest scores. The study provides insights into how adjusting the AS/BS ratio during production can enhance the quality of liangpi. [Extracted from the article]

A recent study conducted in Wuxi, People's Republic of China, focused on assessing the psychological health of children aged 3-7 and examining the relationship between dietary behaviors, lifestyle, and psychological issues. The research, which included 3727 preschool children, found that factors such as low dietary diversity, consumption of ultra-processed foods, distracted eating habits, excessive screen time, and unhealthy sleep patterns were associated with an increased risk of psychological problems. The study suggests the importance of targeted interventions to address these risk factors and improve the well-being of preschool children in the region. [Extracted from the article]

A report from Jiangnan University in Wuxi, People's Republic of China, discusses the development and evaluation of a novel theranostic radiopharmaceutical, [Ga-68]Ga/[Lu-177]Lu-NYM032, for the treatment of prostate cancer. The radiopharmaceutical showed promising diagnostic and therapeutic potential in preclinical and clinical studies, with high specificity and uptake in cancerous lesions. Researchers concluded that [Ga-68]Ga/[Lu-177]Lu-NYM032 has significant potential as a powerful theranostic agent for prostate cancer treatment. The study was peer-reviewed and published in the European Journal of Nuclear Medicine and Molecular Imaging. [Extracted from the article]

A study conducted at Jiangnan University in Wuxi, People's Republic of China, focused on developing a nanoplatform for the detection and inactivation of Salmonella typhimurium, a common pathogen causing intestinal infections through contaminated food and water. The nanoplatform, utilizing an aptamer, demonstrated precise detection and rapid inactivation of the bacteria through near-infrared fluorescence imaging and photothermal and photodynamic effects. The research highlights the potential of this technology for disease surveillance, epidemiological studies, and improving food safety and public health. For more information, readers can contact the State Key Laboratory of Food Science and Resources at Jiangnan University in Wuxi, People's Republic of China. [Extracted from the article]

A study conducted at Jiangnan University in Wuxi, People's Republic of China, focused on the development of a novel siRNA-based therapy for inhibiting Hepatitis B Virus (HBV) replication. The research aimed to address the limitations of current antiviral therapies for chronic HBV infection, which have low cure rates and limited efficacy in reducing HBV antigen levels. The study found that the siRNA, HT-101, showed promising results in inhibiting HBV biomarkers across different genotypes and reducing HBV antigenemia, suggesting a potential strategy for achieving a functional cure for HBV. The preclinical data indicated that HT-101 could significantly reduce antigens and may offer a breakthrough in HBV treatment. [Extracted from the article]

A study conducted at Jiangnan University in Wuxi, China, explored the effects of Centella asiatica (CA) on psoriasis treatment through in vitro and in vivo experiments. The research highlighted the potential of CA in alleviating psoriasis by targeting the JAK/STAT3 signaling pathway. CA extracts demonstrated antioxidant properties, anti-inflammatory effects, and improved skin barrier function, suggesting its potential use in functional food and skincare products. The study was funded by the National Natural Science Foundation of China and the Fundamental Research Funds for the Central Universities. [Extracted from the article]

The article discusses a study conducted in Wuxi, People's Republic of China, on the association between psychological resilience, social support, and oral health behaviors in patients with implant dentures. The research found that factors such as age, economic status, social support, and oral health behaviors influence the psychological resilience of these patients. The study concluded that healthcare professionals should implement targeted nursing interventions to enhance patients' psychological resilience, improve their oral health behaviors, and enhance their quality of life. [Extracted from the article]

A recent study from Jiangnan University in Wuxi, People's Republic of China, focused on addressing the decomposition of urea in aqueous formulations, hindering its broader application in pharmaceuticals and cosmetics. Researchers developed an effective cocrystal strategy involving anhydrous citric acid to stabilize urea, reducing its decomposition rate by over 10%. The study confirmed that this cocrystal approach did not compromise urea's moisturizing properties, as demonstrated through hyaluronidase inhibition assays. This research, supported by the Jiangsu Provincial Market Supervision Administration Science and Technology Plan Project, offers valuable insights into enhancing the utility of urea in various industries. [Extracted from the article]

A report from Jiangnan University in Wuxi, China, discusses innovative research on biotechnology focusing on the production of cultured meat integrating both muscle and fat tissues. The study utilized 3D bioprinting and co-differentiation of muscle and fat cells to create cultured streaky pork with defined compositions. The findings offer new strategies for producing cultured meat that closely resembles real meat in tissue composition and spatial structure, providing valuable insights for the field of biotechnology and stem cell research. [Extracted from the article]

Researchers at Jiangnan University in Wuxi, China, conducted a study comparing camellia oils obtained through different extraction methods using proton nuclear magnetic resonance (1H NMR) and chemometrics. The study found that 1H NMR combined with chemometrics can efficiently classify different camellia oils and potentially other vegetable oils. This research, funded by the National First-Class Discipline Program of Food Science and Technology, provides valuable insights into the chemical analysis of camellia oil. [Extracted from the article]

A study conducted at Jiangnan University in Wuxi, People's Republic of China, introduced a new mask-fill-based 3D molecule generation model driven by atomic chemical properties (APMG) to enhance virtual drug design. The research aimed to address limitations in existing methods by incorporating electronic information into atom representations and optimizing atomic position training data using the Chi-Square distribution. Results showed the superiority of the APMG method over current approaches, emphasizing the importance of utilizing chemical properties for high-quality molecule generation. This peer-reviewed study provides valuable insights into the intersection of obesity, fitness, and wellness in the field of computational biology and bioinformatics. [Extracted from the article]

Researchers from Jiangnan University in Wuxi, People's Republic of China, have developed a new method for predicting Drug-Target Interactions (DTI) using Multi-Modal feature fusion and Domain Generalization (MMDG-DTI). By combining textual features from Large Language Models (LLMs) and structural features from a Graph Neural Network (GNN), the proposed method achieves state-of-the-art performance in both single-domain and cross-domain settings. The research, funded by various organizations, aims to enhance the generalization capability of deep networks for DTI prediction. The datasets and codes for this research are available on the project homepage, and the full study can be accessed through the DOI link provided. [Extracted from the article]

A recent study conducted at Jiangnan University in Wuxi, People's Republic of China, has developed a highly sensitive immunoadsorption assay for detecting Staphylococcal enterotoxin B using a three-way DNA junction amplifier. This innovative approach eliminates the need for traditional horseradish peroxidase for signal amplification. The research achieved high sensitivity for detecting low concentrations of the toxin and confirmed its applicability through a recovery study of precooked dishes. The study has been peer-reviewed and offers valuable insights into improving detection methods for biological toxins. [Extracted from the article]

Research conducted at Children's Hospital in Wuxi, People's Republic of China, identified a peptide called MDPAO1 in human milk that enhances brown adipose tissue thermogenesis and helps mitigate obesity. The study found that MDPAO1 intervention in lactating mice led to reduced body weight gain, increased brown fat mass, and improved glucose tolerance and insulin sensitivity in a mouse model of high-fat diet-induced obesity. This research offers new insights into the potential of breastfeeding in preventing childhood obesity by activating the thermogenic phenotype of brown adipose tissue. [Extracted from the article]

Researchers at Jiangnan University in Wuxi, China, have developed a flexible microelectromechanical system (MEMS) calorimetric flow sensor using polydimethylsiloxane (PDMS) as a substrate. This sensor, which features double-bridge technology, shows high sensitivity and improved range compared to traditional flow sensors on silicon substrates. The study explores the impact of flexible characteristics on the sensor's design, including different curvatures and overheat temperature values. This research, funded by various organizations, has been peer-reviewed and published in the IEEE Sensors Journal. [Extracted from the article]

A research study conducted at Jiangnan University in Wuxi, People's Republic of China, explores the relationship between enterprise social media (ESM) use and career adaptability among employees. The study found that work-oriented ESM use positively impacts career adaptability through role clarity, while socialization-oriented ESM use positively affects career adaptability through psychological closeness. The research emphasizes the importance of mindfulness in strengthening the positive effects of ESM use on career adaptability, highlighting the need for organizations to cultivate mindfulness among employees. [Extracted from the article]

A study conducted in Wuxi, People's Republic of China, focused on developing a predictive model for early detection of atelectasis in children with Mycoplasma pneumoniae pneumonia (MPP) following standardized treatment. The research identified risk factors such as fever duration, neutrophil ratio, platelet count, ALT value, LDH value, and age, which were incorporated into a predictive model with a sensitivity of 87.97% and specificity of 77.50%. The study concluded that while the model provides a framework for clinical assessment, its generalizability is limited by methodological constraints. [Extracted from the article]

A recent study from Jiangnan University in Wuxi, People's Republic of China, focused on the role of microRNAs (miRNAs) in breast cancer. The research highlighted a novel method using photonic crystals for the multiplexed detection of miRNAs associated with breast cancer. The study demonstrated high sensitivity and specificity in detecting multiple miRNA targets, offering potential for minimally invasive cancer diagnostics and treatment. This peer-reviewed research provides valuable insights into cancer biomarkers and their implications for cancer prevention and early intervention. [Extracted from the article]

A study conducted at Jiangnan University in Wuxi, People's Republic of China, focused on the preparation, applications, and perspectives of polyvinyl alcohol/lignin (nano)composites. Polyvinyl alcohol (PVA) and lignin are bio-based materials with various beneficial properties, such as biodegradability, biocompatibility, and mechanical strength. The research highlighted the potential uses of these composites in areas like antibacterial, antioxidative, anti-UV, and flame retardant materials. The study also emphasized the importance of developing environmentally friendly methods for the production and modification of these composites for potential commercialization. [Extracted from the article]

A study conducted by the Chinese Academy of Fishery Sciences in Wuxi, People's Republic of China, explored the effects of dietary fermented mulberry leaf meal (FML) on endoplasmic reticulum stress (ERS) and Ca2+ dysregulation in response to ammonia nitrogen exposure in Megalobrama amblycephala juveniles. The research found that juveniles fed the FML2 diet showed better tolerance to ammonia nitrogen stress, with FML2 supplementation alleviating plasma biochemical parameter deterioration, reducing oxidative stress, and inhibiting inflammation and autophagy. The study concluded that FML2 supplementation helped reduce autophagy and inflammation caused by ERS and imbalanced Ca2+ transport in response to ammonia nitrogen exposure. [Extracted from the article]

Researchers at Jiangnan University in Wuxi, People's Republic of China, have developed a method to enhance the specific activity of 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) through cross-regional combinatorial mutagenesis. By strategically identifying key mutation sites within the enzyme and conducting experimental verification, they were able to create an optimal mutant with significantly increased enzymatic activity. This study provides valuable insights into improving enzyme efficiency for clinical and biotechnological applications. For more information, readers can refer to the International Journal of Biological Macromolecules. [Extracted from the article]

Researchers at Jiangnan University in Wuxi, China, have developed a multifunctional drug delivery system using tetrahedral DNA nanostructures to treat non-small cell lung cancer (NSCLC). The system combines intracellular imaging and drug delivery to target NSCLC adenocarcinoma cells, demonstrating a reduction in cell growth and viability. This innovative approach shows promise for the diagnosis and treatment of tumor cells, highlighting the potential of DNA nanostructures in the biomedical field. [Extracted from the article]

A recent study conducted at Jiangnan University in Wuxi, People's Republic of China, focused on developing an intelligent nanosystem for light-activated synergistic multimodal therapy of drug-resistant breast cancer. The research highlighted the limitations of chemotherapy in treating drug-resistant breast cancer due to intratumoral hypoxia and adaptive antioxidation. By utilizing ZIF-90 nanoparticles to deliver a hypoxia-induced drug and photosensitizer into breast cancer cells, the study demonstrated significant anticancer effects both in vitro and in vivo, offering a promising treatment paradigm for drug-resistant breast cancer under hypoxic conditions. The research was supported by the National Natural Science Foundation of China and Wuxi Taihu Lake Talent Plan. [Extracted from the article]

Researchers at Nanjing Medical University conducted a study in Wuxi, China, to assess the knowledge of radiation dose and associated risks among radiology staff in tertiary hospitals. The study found that there is a prevalent underestimation of radiation dose and cancer risk, which could lead to suboptimal scanning parameters and potential overuse of radiation in daily practice. The research was funded by various organizations in Wuxi and has been peer-reviewed, providing valuable insights into radioprotection practices in the region. [Extracted from the article]

Researchers from Jiangnan University in Wuxi, China, have explored the potential applications of biomimetic materials inspired by pearls in food packaging. The study delves into the formation, structure, and properties of pearl layers, highlighting how these materials can be used in food packaging as protectants and sensors. The research suggests that nacre-inspired biomimetic materials can mimic the optical properties, mechanical strength, barrier capabilities, and hydrophobicity of natural pearls, offering novel possibilities for enhancing food quality, safety, and authenticity. [Extracted from the article]

Researchers at Jiangnan University in Wuxi, China, have developed an interpretable machine learning model that uses erythrocyte fatty acids to identify coronary artery disease (CAD) among Chinese adults. The study involved 628 participants and identified seven erythrocyte fatty acids as independent predictors for CAD risk. The extreme gradient boosting (XGBoost) model showed optimal predictive performance, with an area under the curve of 0.885. The researchers emphasized the need for further validation through large-scale prospective studies. [Extracted from the article]

A recent study conducted by Nanjing University of Chinese Medicine in Wuxi, China, analyzed the association between climatic factors and varicella incidence from 2010 to 2019. The study found that varicella outbreaks in Wuxi displayed a bimodal annual pattern, with several meteorological factors influencing varicella risk. Subgroup analyses revealed that different age groups and genders faced varying levels of varicella risk based on meteorological conditions. The research provides valuable insights for developing public health policies to reduce varicella risks in the region. [Extracted from the article]

Researchers at Jiangnan University in Wuxi, People's Republic of China, have identified the 279th residue of aspartate kinase in Corynebacterium glutamicum as crucial for relieving feedback inhibition by L-lysine and L-threonine. By creating a desensitizing CgAK variant, they were able to increase L-lysine production in the bacterium. This study sheds light on the key role of CgAK in L-lysine biosynthesis and provides insights for developing high enzyme activity variants. [Extracted from the article]

Researchers at Jiangnan University in Wuxi, China, have developed a new method called Multicenter Knowledge Transfer Calibration with rapid zeroth-order TSK fuzzy system (MKTC-R0T) to improve the diagnosis and classification of epileptic EEG signals. This innovative learning framework aims to enhance model generalizability and classification accuracy in the face of inconsistent sample quality and heterogeneity. The research, supported by the National Natural Science Foundation of China, demonstrates the potential of MKTC-R0T in improving the efficiency and accuracy of epilepsy EEG signal diagnosis and classification. [Extracted from the article]

Researchers from Jiangnan University in Wuxi, China, conducted a study on the effects of heat-treated spirulina proteins and their enzymatic hydrolysates on osteoporosis under simulated microgravity conditions. The study found that these proteins and hydrolysates significantly preserved skeletal morphology, suppressed bone resorption, and enhanced bone density, with microwave-treated spirulina protein hydrolysate showing the most pronounced improvement effects. The research suggests that these findings could potentially be used as a dietary strategy for managing osteoporosis in space environments. The study was supported by various funding sources and has been peer-reviewed. [Extracted from the article]

A study conducted at Nantong University in Wuxi, People's Republic of China, analyzed the distribution characteristics of specific IgE to dust mite components in patients with atopic dermatitis. The research aimed to provide a reference basis for the development of microarray protein chips for allergen component discrimination diagnosis and personalized desensitization therapy. Results showed high positivity rates for specific IgE antibodies, suggesting potential for personalized treatment strategies. The study was funded by various organizations and has been peer-reviewed, offering practical recommendations for managing atopic dermatitis. [Extracted from the article]

A study conducted at Jiangnan University in Wuxi, People's Republic of China, focused on developing a photoacoustic probe called Hcy-CE for in vivo imaging of carboxylesterase in lipid metabolic disorders. The probe showed potential for monitoring carboxylesterase levels in induced foam cells and enabled in vivo imaging in model mice. The research aims to provide valuable information for the accurate diagnosis and regulation of lipid metabolism-related disorders. The study was supported by various funding sources and has been peer-reviewed. [Extracted from the article]

Researchers from Jiangnan University in Wuxi, People's Republic of China, conducted a study on the effects of dietary D-lactate intake on metabolic syndrome in diet-induced obese mice. The study found that D-lactate was more effective than L-lactate in reducing body weight, improving glucolipid metabolism, and activating brown adipose tissue. The research highlights the importance of distinguishing between D-lactate and L-lactate for dietary interventions in metabolic health. This peer-reviewed study provides novel insights into potential dietary interventions for metabolic syndrome. [Extracted from the article]

Research conducted at Nanjing Medical University in Wuxi, People's Republic of China, has provided new insights into the immuno-oncology-microbiome axis in biotechnology. The study explores the interactions between the immune system, cancer cells, and microbial components, highlighting the potential for microbial therapies in oncotherapy. This research, supported by various organizations including the NIH National Cancer Institute, emphasizes the importance of microbiome sequencing technologies in understanding host-microbe interactions and developing novel therapies. [Extracted from the article]

Researchers from Jiangnan University conducted a study on the application of radiography in treating allergic rhinitis asthma syndrome (ARAS) with traditional Chinese medicine. The study aimed to evaluate the effects of traditional Chinese medicine on ARAS by comparing imaging changes before and after treatment. The results showed that traditional Chinese medicine significantly reduced inflammation in the nasal cavity and lungs, as observed through X-ray images, providing a scientific basis for clinical treatment. This research was funded by various organizations in Wuxi, People's Republic of China, and was published in the Journal of Radiation Research and Applied Sciences. [Extracted from the article]

Researchers at Jiangnan University in Wuxi, China, have explored the potential of combining microwave and hot air technology for home cooking, which is commonly used in the food industry for drying. This new cooking method shows promise for applications such as baking, frying, reheating, and thawing, offering advantages over traditional cooking methods. By enhancing energy conversion efficiency and reducing cooking time, this innovative approach broadens the capabilities of household microwave ovens and may shape the future of digital cooking. The study was supported by various organizations and has been peer-reviewed, providing valuable insights into the evolving landscape of food science and technology. [Extracted from the article]

Researchers at Jiangnan University in Wuxi, People's Republic of China, have developed a chitosan film loaded with carbon dots and an inclusion complex of geraniol and hydroxypropyl- B-cyclodextrin for freshness preservation and quality monitoring of pork. The composite film exhibited UV shielding, water vapor barrier, antioxidant properties, and antimicrobial effects against Escherichia coli and Staphylococcus aureus. This study suggests that the composite film has potential applications in monitoring and controlling food safety, particularly in the context of pork spoilage. [Extracted from the article]

Researchers from Nanjing Medical University in Wuxi, China, have conducted a study on the detection of bone cancer-related diseases in biological systems. The study highlights the importance of early detection and treatment of bone lesions to improve patient prognosis and quality of life. By utilizing multimodal probes, such as Near-Infrared and photoacoustic imaging, researchers aim to enhance the specificity and sensitivity of conventional detection methods for bone cancers. Understanding current probe technologies is crucial for advancing the early diagnosis and treatment of bone cancers. [Extracted from the article]

Researchers from Jiangnan University in Wuxi, People's Republic of China, conducted a study on diabetes and vascular endothelial dysfunction in diabetic mice. The study focused on comparing cellular and molecular properties of the aorta in normal and diabetic mice, revealing 10 distinct cell types. This research was supported by the National Natural Science Foundation of China and has been peer-reviewed. For more information, the study "Complement Factor C1q Mediates Vascular Endothelial Dysfunction In Stz-induced Diabetic Mice" can be found in the journal Diabetes. [Extracted from the article]

Researchers at Jiangnan University in Wuxi, China, have developed a new nanoplatform for the treatment of drug-resistant breast cancer using antisense oligonucleotides and photothermal therapy. The nanoplatform showed promising results in inhibiting cancer cell proliferation and migration in vitro. This research highlights the potential of this multifunctional nanosystem for effective cancer therapy, offering enhanced biocompatibility and drug release behavior. [Extracted from the article]

Researchers from Jiangnan University in Wuxi, People's Republic of China, have found that D-serine can alleviate acute colitis by regulating intestinal alpha 1,2-fucosylation. The study showed that D-serine helped maintain gut microbiota balance, reduced harmful bacteria, and increased beneficial bacteria. The research suggests that regulating intestinal alpha 1,2-fucosylation could be a potential strategy for treating colitis. [Extracted from the article]