1. Expression of the interleukin 17 in cortical tubers of the tuberous sclerosis complex.
- Author
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He, Jiao-Jiang, Wu, Ke-Fu, Li, Song, Shu, Hai-Feng, Zhang, Chun-Qing, Liu, Shi-Yong, Yang, Mei-Hua, Yin, Qing, and Yang, Hui
- Subjects
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INTERLEUKIN-17 , *TUBEROUS sclerosis , *DIAGNOSIS of epilepsy , *NATURAL immunity , *ENDOTHELIAL cells , *COMPARATIVE studies , *THERAPEUTICS - Abstract
Abstract: The role of interleukin 17 (IL-17) to epilepsy-associated cortical tubers of tuberous sclerosis complex (TSC) is unknown. We investigated the expression patterns of the IL-17 and IL-17 receptor (IL-17R) in cortical tubers of TSC compared with normal control cortex (CTX). We found that IL-17 and IL-17R were clearly upregulated in cortical tubers at the protein levels. Immunostaining indicated that IL-17 was specifically distributed in the innate immunity cells (DNs, GCs, astrocytes, and microglia) and adaptive immunity cells (T-lymphocytes) as well as the endothelial cells of blood vessels. The overexpression and distribution patterns of IL-17 may be involved in the epileptogenicity of cortical tubers in TSC. [Copyright &y& Elsevier]
- Published
- 2013
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