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Expression of the interleukin 17 in cortical tubers of the tuberous sclerosis complex.
- Source :
-
Journal of Neuroimmunology . Sep2013, Vol. 262 Issue 1/2, p85-91. 7p. - Publication Year :
- 2013
-
Abstract
- Abstract: The role of interleukin 17 (IL-17) to epilepsy-associated cortical tubers of tuberous sclerosis complex (TSC) is unknown. We investigated the expression patterns of the IL-17 and IL-17 receptor (IL-17R) in cortical tubers of TSC compared with normal control cortex (CTX). We found that IL-17 and IL-17R were clearly upregulated in cortical tubers at the protein levels. Immunostaining indicated that IL-17 was specifically distributed in the innate immunity cells (DNs, GCs, astrocytes, and microglia) and adaptive immunity cells (T-lymphocytes) as well as the endothelial cells of blood vessels. The overexpression and distribution patterns of IL-17 may be involved in the epileptogenicity of cortical tubers in TSC. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01655728
- Volume :
- 262
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 90092721
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2013.05.007