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13 results on '"Win, Yi Yi"'

9. Picrajavanicins H-M, New Quassinoids from Picrasma javanica Collected in Myanmar and their antiproliperative activities

Author

Win, Nwet Nwet, Ito, Takuya, Ismail, Kodama, Takeshi, Win, Yi Yi, Tanaka, Masami, Okamoto, Yasuko, Imagawa, Hiroshi, Ngwe, Hla, Asakawa, Yoshinori, Abe, Ikuro, and Morita, Hiroyuki

Subjects
Picrasma Javanica, Quassinoid, Antiprolifderative activities, Picrajavanicins H-M
Abstract

Six new tetracyclic quassinoids, picrajavanicins HeM, along with two known analogues were isolated from the CHCl3 soluble extract of Picrasma javanica bark collected in Myanmar. The structures of these compounds were elucidated using spectroscopic techniques, including 1D and 2D NMR. The absolute con???guration at C-4 of picrajavanicin L was determined to be R by the modi???ed Mosher method. In contrast, the absolute structures of picrajavanicin H and picrasin A were determined by the X-ray dif- fraction analyses. The antiproliferative activities of the isolated compounds were evaluated against a panel of ???ve different human cancer cell lines. All isolates exhibited potent and selective anti- proliferative activities against human pancreatic cancer PANC-1 cells, with IC50 values ranging from 3.25 to 17.41 mM.

Published
2015

11. Picrajavanicins A–G, Quassinoids from Picrasma javanicaCollected in Myanmar

Author

Win, Nwet Nwet, Ito, Takuya, Ismail, Kodama, Takeshi, Win, Yi Yi, Tanaka, Masami, Ngwe, Hla, Asakawa, Yoshinori, Abe, Ikuro, and Morita, Hiroyuki

Abstract

Seven new tetracyclic quassinoids, picrajavanicins A–G (1–7), along with three known analogues, were isolated from a CHCl3-soluble extract of the bark of Picrasma javanicacollected in Myanmar. The structures of these compounds were elucidated using spectroscopic techniques, including 1D and 2D NMR. The absolute configuration at C-2 of 2was determined to be Sby the modified Mosher method. All the isolates were tested for their antiproliferative activities against a small panel of five human cancer cell lines. However, none of the isolated compounds exhibited inhibitory activity against any of the cancer cells used (IC50values >10 μM).

Published
2015
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12. Labdane diterpenoids from Curcuma amada rhizomes collected in Myanmar and their antiproliferative activities.

Author

Win, Nwet Nwet, Ito, Takuya, Ngwe, Hla, Win, Yi Yi, Prema, null, Okamoto, Yasuko, Tanaka, Masami, Asakawa, Yoshinori, Abe, Ikuro, and Morita, Hiroyuki

Subjects
*ALTERNATIVE medicine, *ANTINEOPLASTIC agents, *BIOLOGICAL models, *BREAST tumors, *PHYSICAL & theoretical chemistry, *DOSE-effect relationship in pharmacology, *LUNG tumors, *MEDICINAL plants, *PANCREATIC tumors, *SPECTRUM analysis, *PLANT extracts, *DESCRIPTIVE statistics, *IN vitro studies, *PHARMACODYNAMICS, CERVIX uteri tumors
Abstract

Four new labdane diterpenoids, 12 β -hydroxy-15-norlabda-8(17),13(14)-dien-16-oic acid ( 1 ), ( E )-15-ethoxy-15-methoxylabda-8(17),12-dien-16-al ( 2 ), ( E )-15 α -ethoxy-14 α -hydroxylabda-8(17),12-dien-16-olide ( 3 ), and 15-ethoxy-12 β -hydroxylabda-8(17),13(14)-dien-16,15-olide ( 4 ) were isolated from the methanol extract of Curcuma amada rhizomes collected in Myanmar, together with 13 known analogs. Their structures were elucidated by extensive spectroscopic techniques. All of the isolates were evaluated for their antiproliferative activities against a small panel of five different human cancer cell lines (A549, human lung cancer; HeLa, human cervical cancer; MCF7, human breast cancer; PANC-1 and PSN-1, human pancreatic cancer). Among the isolates, compounds 2 − 4 , 7 , 8 , 12 , and 17 showed mild antiproliferative activities with IC 50 values ranging from 19.7 to 96.1 μM. ( E )-14-Hydroxy-15-norlabda-8(17),12-dien-16-al ( 11 ) exhibited strong antiproliferative activities selectively against HeLa, PANC-1, and PSN-1 cells, with IC 50 values of 5.88, 1.00, and 3.98 μM, respectively. These potencies were comparable to those of the positive control, 5-fluorouracil. [ABSTRACT FROM AUTHOR]

Published
2017
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13. Picrajavanicins A-G, Quassinoids from Picrasma javanica Collected in Myanmar.

Author

Win NN, Ito T, Ismail, Kodama T, Win YY, Tanaka M, Ngwe H, Asakawa Y, Abe I, and Morita H

Subjects
Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic pharmacology, Drug Screening Assays, Antitumor, Humans, Inhibitory Concentration 50, Molecular Structure, Myanmar, Nuclear Magnetic Resonance, Biomolecular, Plant Bark chemistry, Quassins chemistry, Quassins pharmacology, Antineoplastic Agents, Phytogenic isolation & purification, Picrasma chemistry, Quassins isolation & purification
Abstract

Seven new tetracyclic quassinoids, picrajavanicins A-G (1-7), along with three known analogues, were isolated from a CHCl3-soluble extract of the bark of Picrasma javanica collected in Myanmar. The structures of these compounds were elucidated using spectroscopic techniques, including 1D and 2D NMR. The absolute configuration at C-2 of 2 was determined to be S by the modified Mosher method. All the isolates were tested for their antiproliferative activities against a small panel of five human cancer cell lines. However, none of the isolated compounds exhibited inhibitory activity against any of the cancer cells used (IC50 values >10 μM).

Published
2015
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