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Picrajavanicins A-G, Quassinoids from Picrasma javanica Collected in Myanmar.
- Source :
-
Journal of natural products [J Nat Prod] 2015 Dec 24; Vol. 78 (12), pp. 3024-30. Date of Electronic Publication: 2015 Nov 25. - Publication Year :
- 2015
-
Abstract
- Seven new tetracyclic quassinoids, picrajavanicins A-G (1-7), along with three known analogues, were isolated from a CHCl3-soluble extract of the bark of Picrasma javanica collected in Myanmar. The structures of these compounds were elucidated using spectroscopic techniques, including 1D and 2D NMR. The absolute configuration at C-2 of 2 was determined to be S by the modified Mosher method. All the isolates were tested for their antiproliferative activities against a small panel of five human cancer cell lines. However, none of the isolated compounds exhibited inhibitory activity against any of the cancer cells used (IC50 values >10 μM).
- Subjects :
- Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic pharmacology
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
Molecular Structure
Myanmar
Nuclear Magnetic Resonance, Biomolecular
Plant Bark chemistry
Quassins chemistry
Quassins pharmacology
Antineoplastic Agents, Phytogenic isolation & purification
Picrasma chemistry
Quassins isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 78
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 26606140
- Full Text :
- https://doi.org/10.1021/acs.jnatprod.5b00824