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Labdane diterpenoids from Curcuma amada rhizomes collected in Myanmar and their antiproliferative activities.
- Source :
-
Fitoterapia . Oct2017, Vol. 122, p34-39. 6p. - Publication Year :
- 2017
-
Abstract
- Four new labdane diterpenoids, 12 β -hydroxy-15-norlabda-8(17),13(14)-dien-16-oic acid ( 1 ), ( E )-15-ethoxy-15-methoxylabda-8(17),12-dien-16-al ( 2 ), ( E )-15 α -ethoxy-14 α -hydroxylabda-8(17),12-dien-16-olide ( 3 ), and 15-ethoxy-12 β -hydroxylabda-8(17),13(14)-dien-16,15-olide ( 4 ) were isolated from the methanol extract of Curcuma amada rhizomes collected in Myanmar, together with 13 known analogs. Their structures were elucidated by extensive spectroscopic techniques. All of the isolates were evaluated for their antiproliferative activities against a small panel of five different human cancer cell lines (A549, human lung cancer; HeLa, human cervical cancer; MCF7, human breast cancer; PANC-1 and PSN-1, human pancreatic cancer). Among the isolates, compounds 2 − 4 , 7 , 8 , 12 , and 17 showed mild antiproliferative activities with IC 50 values ranging from 19.7 to 96.1 μM. ( E )-14-Hydroxy-15-norlabda-8(17),12-dien-16-al ( 11 ) exhibited strong antiproliferative activities selectively against HeLa, PANC-1, and PSN-1 cells, with IC 50 values of 5.88, 1.00, and 3.98 μM, respectively. These potencies were comparable to those of the positive control, 5-fluorouracil. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALTERNATIVE medicine
*ANTINEOPLASTIC agents
*BIOLOGICAL models
*BREAST tumors
*PHYSICAL & theoretical chemistry
*DOSE-effect relationship in pharmacology
*LUNG tumors
*MEDICINAL plants
*PANCREATIC tumors
*SPECTRUM analysis
*PLANT extracts
*DESCRIPTIVE statistics
*IN vitro studies
*PHARMACODYNAMICS
CERVIX uteri tumors
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 122
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 125374738
- Full Text :
- https://doi.org/10.1016/j.fitote.2017.08.006