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5,620 results on '"University of São Paulo (USP)"'

1. Benefits associated with the standing position during visual search tasks

Author: Cédrick T. Bonnet, Tarkeshwar Singh, Jose A. Barela, Université de Lille, CNRS, CHU Lille, Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab], Pennsylvania State University [Penn State], Universidade de São Paulo = University of São Paulo [USP], Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Pennsylvania State University (Penn State), Penn State System, and Universidade de São Paulo = University of São Paulo (USP)
Subjects: [SCCO]Cognitive science, Postural sway, Sitting position · Standing position, Task performance, Selectivity of attention, Young adults, General Neuroscience
Abstract: International audience; The literature on postural control highlights that task performance should be worse in challenging dual tasks than in a single task because the brain has limited attentional resources. Instead, in the context of visual tasks, we assumed that i) performance in a visual search task should be better when standing than when sitting and ii) when standing, postural control should be better when searching than performing the control task. 32 and 16 young adults participated in studies 1 and 2, respectively. They performed three visual tasks (searching to locate targets, free-viewing and fixating a stationary cross) displayed in small images (visual angle: 22°) either when standing or when sitting. Task performance, eye, head, upper back, lower back and center of pressure displacements were recorded. In both studies, task performance in searching was as good (and clearly not worse) when standing as when sitting. Sway magnitude was smaller during the search task (vs. other tasks) when standing but not when sitting. Hence, only when standing, postural control was adapted to perform the challenging search task. When exploring images, and especially so in the search task, participants rotated their head instead of their eyes as if they used an eye-centered strategy. Remarkably in Study 2, head rotation was greater when sitting than when standing. Overall, we consider that variability in postural control was not detrimental but instead useful to facilitate visual task performance. When sitting, this variability may be lacking, thus requiring compensatory movements.
Published: 2022

2. Adherence with positive airway pressure therapy for obstructive sleep apnea in developing vs. developed countries: a big data study

Author: Yang Yan, Peter A. Cistulli, Jeff Armitstead, Holger Woehrle, Luciano F. Drager, Jean-Louis Pépin, Carlos M Nunez, Atul Malhotra, Adam Benjafield, University of São Paulo (USP), University of California [San Diego] (UC San Diego), University of California, ResMed Science Center, Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Lung Center Ulm, The University of Sydney, ANR-19-P3IA-0003,MIAI,MIAI @ Grenoble Alpes(2019), BAILLY, Sébastien, MIAI @ Grenoble Alpes - - MIAI2019 - ANR-19-P3IA-0003 - P3IA - VALID, Universidade de São Paulo = University of São Paulo (USP), University of California (UC), and Hypoxie et PhysioPathologie (HP2)
Subjects: Big Data, 0302 clinical medicine, Positive airway pressure, Psychology, adherence, ComputingMilieux_MISCELLANEOUS, Sleep Apnea, Obstructive, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Continuous Positive Airway Pressure, treatment, Sleep apnea, Health Services, Scientific Investigations, 3. Good health, wearables, Neurology, telemedicine, Sleep Research, Developed country, Brazil, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Telemedicine, Sleep Apnea, Clinical Sciences, Developing country, Medicare, lung, 03 medical and health sciences, Clinical Research, medXcloud group, medicine, Humans, Intensive care medicine, Mexico, Retrospective Studies, Aged, Other Medical and Health Sciences, Neurology & Neurosurgery, Obstructive, business.industry, Developed Countries, medicine.disease, United States, respiratory tract diseases, Health care delivery, Obstructive sleep apnea, Good Health and Well Being, Patient Compliance, Neurology (clinical), business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery
Abstract: STUDY OBJECTIVES: Minimal focus has been placed on variations in health care delivery for obstructive sleep apnea (OSA). This study compared positive airway pressure usage in developing countries (Brazil and Mexico) vs. a developed country (United States) and investigated the impact of a patient engagement tool (myAir; ResMed, San Diego, CA) on adherence. METHODS: Deidentified data from the AirView database (ResMed) for patients receiving positive airway pressure therapy with wirelessly connected Air10 (AirSense and AirCurve) devices in Brazil, Mexico, and the United States were analyzed. Adherence was defined using US Center for Medicare and Medicaid Services (CMS) criteria (usage ≥ 4 h/night on ≥ 70% of nights in the first 90 days). RESULTS: The analysis included 4,181,490 patients (Brazil: 31,672; Mexico 16,934; United States: 4,132,884). CMS adherence over 90 days was slightly lower in Latin America vs. the United States (Brazil: 71.7%; Mexico: 66.4%; United States: 74.0%). Significantly fewer patients were using the patient engagement tool in Brazil (8.1%) and Mexico (2.8%) vs. the United States (26%; both P < .001). Patients registered to use an engagement tool had a higher rate of CMS adherence and were twice as likely to achieve CMS adherence. Average daily usage and days with usage > 4 hours in the first week were the strongest predictors of CMS adherence. Across all countries, > 80% of patients meeting CMS criteria at 3 months were still using positive airway pressure therapy at 1 year, with 1-year adherences rates of > 75%. CONCLUSIONS: Short-term and long-term positive airway pressure adherence rates in Brazil and Mexico were similar to those achieved in the United States. Patients who registered to use an engagement tool consistently had better adherence than those who did not. CITATION: Drager LF, Malhotra A, Yan Y, et al. Adherence with positive airway pressure therapy for obstructive sleep apnea in developing vs developed countries: a big data study. J Clin Sleep Med. 2021;17(4):703–709.
Published: 2021

3. The cost of eating more sustainable diets: A nutritional and environmental diet optimisation study

Author: Nicole Darmon, Aline Martins de Carvalho, Eliseu Verly-Jr, Dirce Maria Lobo Marchioni, Universidade Federal do Rio de Janeiro (UFRJ), University of São Paulo (USP), Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) (UMR MoISA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Montpellier (CIHEAM-IAMM), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), This work was supported by Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro: [Grant Number E26/201.488/2014], Universidade de São Paulo = University of São Paulo (USP), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)
Subjects: Sustainable diet, Diet cost, Food habits, Greenhouse Gases, 03 medical and health sciences, 0302 clinical medicine, Linear programming, Environmental health, Greenhouse gas emissions, Humans, 030212 general & internal medicine, 2. Zero hunger, Family Characteristics, 030505 public health, Public Health, Environmental and Occupational Health, Healthy diet, Diet, 3. Good health, 13. Climate action, Greenhouse gas, Environmental science, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, sense organs, 0305 other medical science, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Brazil
Abstract: International audience; We aim to identify the dietary changes to improve nutrition and reduce diet-related greenhouse gas emission (GHGE) simultaneously in Brazil, taking into account the heterogeneity in food habits and prices across the country. Food consumption and prices were obtained from two nationwide surveys (n = 55,970 households and 34,003 individuals). Linear programming models were performed to design optimised diets most resembling the observed diets, and meeting different sets of constraints: (i) nutritional, for preventing chronic diseases and meeting nutrient adequacy; (ii) socio-cultural: by respecting food preferences; and (iii) environmental: by reducing GHGE by steps of 10%. Moving toward a diet that meets nutritional recommendations led to a 14% to 24% cost increase and 10% to 27% GHGE reduction, depending on the stringency of the acceptability constraints. Stronger GHGE reductions were achievable (up to about 70%), with greater departure from the current diet, but not achieving calcium and potassium goals. Diet cost increment tended to be mitigated with GHGE reduction in most models, along with reductions in red meat, chicken, eggs, rice, and high-fat sugar sodium foods.
Published: 2021

4. Total phosphorus determination in eutrophic tropical river sediments by laser-induced breakdown spectroscopy techniques

Author: Frederico Fábio Mauad, Gustavo Nicolodelli, Stéphane Mounier, Carla Pereira de Morais, Milene Corso Mitsuyuki, Débora Marcondes Bastos Pereira Milori, Kleydson Stênio Gaioso da Silva, Embrapa Instrumentation (CNPDIA), National Nanotechnology Laboratory for Agriculture (LNNA), Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN), Instituto de Química de São Carlos, Universidade de São Paulo, Avenida Trabalhador São-Carlense 400, São Carlos, SP, Brazil, Departamento Física [Florianópolis], Universidade Federal de Santa Catarina = Federal University of Santa Catarina [Florianópolis] (UFSC), Sao Carlos School of engineering [São Paulo], University of São Paulo (USP), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), and Universidade de São Paulo = University of São Paulo (USP)
Subjects: Detection limit, FÓSFORO, Calibration curve, General Chemical Engineering, 010401 analytical chemistry, General Engineering, Sediment, 010501 environmental sciences, 01 natural sciences, 6. Clean water, 0104 chemical sciences, Analytical Chemistry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, [SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, 13. Climate action, Environmental chemistry, Inductively coupled plasma atomic emission spectroscopy, Environmental science, Laser-induced breakdown spectroscopy, Inductively coupled plasma, Eutrophication, Spectroscopy, 0105 earth and related environmental sciences
Abstract: International audience; Total phosphorus (TP) in sediments is an important chemical variable in the study of the extent of eutrophication in water bodies. Two methods, based on Single Pulse (SP) and Double Pulse (DP) Laser-Induced Breakdown Spectroscopy (LIBS), were developed for determining TP in the sediment cores of Brazilian rivers upstream from the Barra Bonita reservoir. TP concentration in the sediments was determined by inductively coupled plasma optical emission spectrometry (ICP OES) on digested samples. Besides, a LIBS system operating in SP and DP mode was used to develop methods for the TP quantification in sediment pellets. In LIBS, the most appropriate wavelength to measure P was at 214.91 nm. The calibration curves showed correlation coefficients of 0.93 and 0.92, limits of detection of 709 mg kg-1 and 349 mg kg-1 for SP and DP LIBS, respectively. The two proposed methods were validated and presented an average percentage error of 14% and 10% for SP and DP LIBS, respectively. The ICP OES, SP and DP LIBS data showed that the most superficial layers of the Piracicaba river, all the sedimentary layers of the Tietê river, and the confluence region present a high concentration of TP, according to Brazilian sediment quality criterion. In conclusion, SP and DP LIBS were confirmed as promising alternative tools to traditional analytical methods for monitoring the TP content in the sediments that come from different hydrographic units. The proposed method using DP LIBS proved more sensitive than SP LIBS, but the SP LIBS method demonstrated enough precision for determining TP in eutrophic river sediments.
Published: 2021

5. Trunk and head displacements stabilized to perform both horizontal and vertical saccadic eye movements

Author: Cédrick T. Bonnet, José Angelo Barela, Gabriella Andreeta Figueiredo, Rafael M. P. Paulo, Ana Maria Forti Barela, Universidade Estadual Paulista (UNESP), Cruzeiro do Sul University, UMR 9193 - SCALab - Sciences Cognitives et Sciences Affectives, University of São Paulo (USP), Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193 (SCALab), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Université de Lille, CNRS, CHU Lille, Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab], Universidade de São Paulo = University of São Paulo (USP), and Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab)
Subjects: medicine.medical_specialty, Horizontal and vertical, genetic structures, Vision, General Neuroscience, Eye movement, Postural control, 030229 sport sciences, Trunk, Saccadic masking, eye diseases, 03 medical and health sciences, [SCCO]Cognitive science, 0302 clinical medicine, Physical medicine and rehabilitation, Coordination, Fixation (visual), Vertical direction, medicine, Saccades, Eye tracking, sense organs, Visual angle, 030217 neurology & neurosurgery, Geology
Abstract: Made available in DSpace on 2022-05-01T10:35:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-02-01 Vision is crucial for humans to interact with their surrounding environment, and postural sway is reduced to allow short eye movements. However, the extent of subtle changes in postural control for horizontal and vertical eye movements remains unclear. The goal of this study was to investigate the effects of vertical and horizontal eye movements on head and trunk control in young adults. Fifteen healthy adults (23.4 ± 4.7 years) stood upright in three conditions for 60 s: fixation, horizontal, and vertical guided eye movements. In fixation, participants had to fixate on a stationary target. In both the horizontal and vertical eye movements, the target was presented with a frequency of 0.5 Hz and a visual angle of 11°. Eye displacement was monitored using a SMI eye tracker (ETG2.0) and trunk and head sway were monitored using infrared markers (Optotrak 3020, NDI). The mean sway amplitude was lower in both directions for eye movements and lowest in the vertical direction compared to the fixation condition. The sway area was also lower in vertical eye movement than in the fixation condition. We also found that the sway reduction was greater at head than at trunk level. The median frequency sway in the anterior–posterior direction was higher in both eye movements than in fixation. Based upon these results, we suggest that to perform short eye movements, postural sway is more strongly controlled at the head level than at the trunk and in vertical eye movements than in horizontal movements. Institute of Biosciences São Paulo State University, SP Institute of Physical Activity and Sport Science Cruzeiro do Sul University, SP Univ. Lille CNRS UMR 9193 - SCALab - Sciences Cognitives et Sciences Affectives Departmento de Educação Física Instituto de Biociências Universidade Estadual Paulista, Av. 24-A, 1515, SP Institute of Biosciences São Paulo State University, SP Departmento de Educação Física Instituto de Biociências Universidade Estadual Paulista, Av. 24-A, 1515, SP
Published: 2022

6. Mere end lugtesans - COVID-19 er associeret med svær påvirkning af lugtesansen, smagssansen og mundfølelsen

Author: Parma, Valentina, Ohla, Kathrin, Veldhuizen, Maria G, Niv, Masha Y, Kelly, Christine E, Bakke, Alyssa J, Cooper, Keiland W, Bouysset, Cédric, Pirastu, Nicola, Dibattista, Michele, Kaur, Rishemjit, Liuzza, Marco Tullio, Pepino, Marta Y, Schöpf, Veronika, Pereda-Loth, Veronica, Olsson, Shannon B, Gerkin, Richard C, Rohlfs Domínguez, Paloma, Albayay, Javier, Farruggia, Michael C, Bhutani, Surabhi, Fjaeldstad, Alexander W, Kumar, Ritesh, Menini, Anna, Bensafi, Moustafa, Sandell, Mari, Konstantinidis, Iordanis, Di Pizio, Antonella, Genovese, Federica, Öztürk, Lina, Thomas-Danguin, Thierry, Frasnelli, Johannes, Boesveldt, Sanne, Saatci, Özlem, Saraiva, Luis R, Lin, Cailu, Golebiowski, Jérôme, Hwang, Liang-Dar, Ozdener, Mehmet Hakan, Guàrdia, Maria Dolors, Laudamiel, Christophe, Ritchie, Marina, Havlícek, Jan, Pierron, Denis, Roura, Eugeni, Navarro, Marta, Nolden, Alissa A, Lim, Juyun, Whitcroft, Katherine L, Colquitt, Lauren R, Ferdenzi, Camille, Brindha, Evelyn V, Altundag, Aytug, Macchi, Alberto, Nunez-Parra, Alexia, Patel, Zara M, Fiorucci, Sébastien, Philpott, Carl M, Smith, Barry C, Lundström, Johan N, Mucignat, Carla, Parker, Jane K, van den Brink, Mirjam, Schmuker, Michael, Fischmeister, Florian Ph S, Heinbockel, Thomas, Shields, Vonnie D C, Faraji, Farhoud, Santamaría, Enrique, Fredborg, William E A, Morini, Gabriella, Olofsson, Jonas K, Jalessi, Maryam, Karni, Noam, D’Errico, Anna, Alizadeh, Rafieh, Pellegrino, Robert, Meyer, Pablo, Huart, Caroline, Chen, Ben, Soler, Graciela M, Alwashahi, Mohammed K, Welge-Lüssen, Antje, Freiherr, Jessica, de Groot, Jasper H B, Klein, Hadar, Okamoto, Masako, Singh, Preet Bano, Hsieh, Julien W, Abdulrahman, Olagunju, Dalton, Pamela, Yan, Carol H, Voznessenskaya, Vera V, Chen, Jingguo, Sell, Elizabeth A, Walsh-Messinger, Julie, Archer, Nicholas S, Koyama, Sachiko, Deary, Vincent, Roberts, S Craig, Yanık, Hüseyin, Albayrak, Samet, Nováková, Lenka Martinec, Croijmans, Ilja, Mazal, Patricia Portillo, Moein, Shima T, Margulis, Eitan, Mignot, Coralie, Mariño, Sajidxa, Georgiev, Dejan, Kaushik, Pavan K, Malnic, Bettina, Wang, Hong, Seyed-Allaei, Shima, Yoluk, Nur, Razzaghi-Asl, Sara, Justice, Jeb M, Restrepo, Diego, Reed, Danielle R, Hummel, Thomas, Munger, Steven D, Hayes, John E, Indústries Alimentàries, Qualitat i Tecnologia Alimentària, Tecnologia Alimentària, Temple University [Philadelphia], Pennsylvania Commonwealth System of Higher Education (PCSHE), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association, Mersin University, The Hebrew University of Jerusalem (HUJ), AbScent, Pennsylvania State University (Penn State), Penn State System, University of California [Irvine] (UC Irvine), University of California (UC), Université Côte d'Azur (UCA), University of Edinburgh, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Central Scientific Instruments Organisation (CSIR), Università degli Studi 'Magna Graecia' di Catanzaro = University of Catanzaro (UMG), University of Illinois at Urbana-Champaign [Urbana], University of Illinois System, Medizinische Universität Wien = Medical University of Vienna, Groupement scientifique de Biologie et de Medecine Spatiale (GSBMS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES), Tata Institute for Fundamental Research (TIFR), Arizona State University [Tempe] (ASU), Universidad de Extremadura - University of Extremadura (UEX), Università degli Studi di Padova = University of Padua (Unipd), Yale School of Medicine [New Haven, Connecticut] (YSM), San Diego State University (SDSU), Aarhus University [Aarhus], University of Hertfordshire [Hatfield] (UH), Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies (SISSA / ISAS), Neurosciences Sensorielles Comportement Cognition, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Turku, Aristotle University of Thessaloniki, Leibniz-Institute for Food Systems Biology at the Technical University of Munich, Monell Chemical Senses Center, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Université de Montréal (UdeM), Wageningen University and Research Centre (WUR), Medical Science University, Sidra Medicine [Doha, Qatar], Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), University of Southern Queensland (USQ), Institut de Recerca i Tecnologia Agroalimentàries = Institute of Agrifood Research and Technology (IRTA), DreamAir Llc, Charles University [Prague] (CU), Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), University of Massachusetts System (UMASS), Oregon State University (OSU), Ear Institute, UCL, Lyon Neuroscience Research center, Karunya University, Biruni University, Assi Sette Llaghi Varese, Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University, University of East Anglia [Norwich] (UEA), California Department of Food and Agriculture (CDFA), Unité mixte de recherche interactions plantes-microorganismes, Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Maastricht University [Maastricht], Institute for Biology - Neurobiology, Freie Universität Berlin, Karl-Franzens-Universität Graz, Howard University College of Medicine, Towson University, University of California [San Diego] (UC San Diego), Proteomics, Center for Applied Medical Research (CIMA), Stockholm University, University of Gastronomic Sciences, Iran University of Medical Sciences, Goethe Universität Frankfurt, University of Tennessee, IBM T.J. Watson Research Center, Université libre de Bruxelles (ULB), Guangzhou Medical University, Buenos Aires University and GEOG (Grupo de Estudio de Olfato y Gusto), Sultan Qaboos University (SQU), Federal University of Technology of Akure (FUTA), A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences [Moscow] (RAS), Hospital of Xi'an Jiaotong University, University of Pennsylvania, University of Dayton, CSIRO Agriculture and Food (CSIRO), Indiana University [Bloomington], Indiana University System, University of Northumbria at Newcastle [United Kingdom], University of Stirling, Middle East Technical University [Ankara] (METU), Utrecht University [Utrecht], Instituto Universitario del Hospital Italiano [Buenos Aires, Argentina], Institute for Research in Fundamental Sciences [Tehran] (IPM), Hebrew University of Jerusalem, Technische Universität Dresden = Dresden University of Technology (TU Dresden), Terrazas del Club Hipico, University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Tata Institute of Fundamental Research [Bangalore], Universidade de São Paulo = University of São Paulo (USP), University of Florida [Gainesville] (UF), University of Colorado Anschutz [Aurora], Center for Smell and Taste, Department of Food Science, Pennsylvania State University., Julien, Sabine, Tıp Fakültesi, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Department of Food and Nutrition, Senses and Food, Research Center Jülich, University of California [Irvine] (UCI), University of California, Università degli studi di Bari Aldo Moro (UNIBA), Università degli Studi 'Magna Graecia' di Catanzaro [Catanzaro, Italie] (UMG), University of Extremadura, University of Padova, Yale University School of Medicine, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, University of Helsinki, Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institute of Agrifood Research and Technology (IRTA), Universita degli Studi di Padova, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Karl-Franzens-Universität [Graz, Autriche], University of California San Diego Health, University of Brussels, University of Pennsylvania [Philadelphia], Tata Institute of Fundamental Research, University of São Paulo (USP), UCL - SSS/IONS - Institute of NeuroScience, FSE Campus Venlo, and RS: FSE UCV
Subjects: Male, Taste, Physiology, Smagstab, Audiology, AcademicSubjects/SCI01180, Settore BIO/09 - Fisiologia, Behavioral Neuroscience, chemistry.chemical_compound, Olfaction Disorders, Taste Disorders, 0302 clinical medicine, RATINGS, Hyposmia, Surveys and Questionnaires, CHEMOSENSITIVITY, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Viral, PALADAR, 030223 otorhinolaryngology, Sensory Science and Eating Behaviour, media_common, TASTE, US NATIONAL-HEALTH, [SDV.IDA] Life Sciences [q-bio]/Food engineering, Middle Aged, Biological Sciences, 16. Peace & justice, Sensory Systems, 3. Good health, Smell, GCCR Group Author, ddc:540, Smell loss, Female, Original Article, medicine.symptom, Corrigendum, Coronavirus Infections, olfaction, Adult, somatosensation, medicine.medical_specialty, 663/664, Coronavirus disease 2019 (COVID-19), OLFACTORY DISORDERS, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), media_common.quotation_subject, Pneumonia, Viral, head and neck surgery, Aged, Betacoronavirus, COVID-19, Humans, Pandemics, SARS-CoV-2, Self Report, Somatosensory Disorders, Young Adult, Anosmia, Sensory system, Olfaction, 03 medical and health sciences, Chemesthesis, Physiology (medical), Perception, medicine, Neurology & Neurosurgery, Behaviour Change and Well-being, business.industry, R-PACKAGE, 3112 Neurosciences, Pneumonia, Parosmia, COMPONENT, Smagssans, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Sensoriek en eetgedrag, chemistry, Lugtetab, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, 030217 neurology & neurosurgery, Lugtesans
Abstract: Correction: Chemical Senses, Volume 46, 2021, bjab050, https://doi.org/10.1093/chemse/bjab050 Published: 08 December 2021 Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change +/- 100) revealed a mean reduction of smell (-79.7 +/- 28.7, mean +/- standard deviation), taste (-69.0 +/- 32.6), and chemesthetic (-37.3 +/- 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis.The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.
Published: 2020

7. Exploration of oxidative chemistry and secondary organic aerosol formation in the Amazon during the wet season: explicit modeling of the Manaus urban plume with GECKO-A

Author: C. Mouchel-Vallon, J. Lee-Taylor, A. Hodzic, P. Artaxo, B. Aumont, M. Camredon, D. Gurarie, J.-L. Jimenez, D. H. Lenschow, S. T. Martin, J. Nascimento, J. J. Orlando, B. B. Palm, J. E. Shilling, M. Shrivastava, S. Madronich, National Center for Atmospheric Research [Boulder] (NCAR), Cooperative Institute for Research in Environmental Sciences (CIRES), University of Colorado [Boulder]-National Oceanic and Atmospheric Administration (NOAA), Institute of Physics [São Paulo], Universidade de São Paulo = University of São Paulo (USP), Laboratoire Interuniversitaire des Systèmes Atmosphériques (LISA (UMR_7583)), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Case Western Reserve University [Cleveland], Department of Chemistry, University of Colorado, University of Colorado [Boulder], Department of Earth and Planetary Sciences [Cambridge, USA] (EPS), Harvard University [Cambridge], Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), National Institute for Amazonian Research, Amazonas State University, ESRL Chemical Sciences Division [Boulder] (CSD), NOAA Earth System Research Laboratory (ESRL), National Oceanic and Atmospheric Administration (NOAA)-National Oceanic and Atmospheric Administration (NOAA), Pacific Northwest National Laboratory (PNNL), and University of São Paulo (USP)
Subjects: Wet season, [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, Atmospheric Science, Ozone, 010504 meteorology & atmospheric sciences, CLIMA, 010501 environmental sciences, Atmospheric sciences, 01 natural sciences, lcsh:QC1-999, Plume, Aerosol, Atmosphere, lcsh:Chemistry, chemistry.chemical_compound, chemistry, lcsh:QD1-999, 13. Climate action, Volatility (chemistry), NOx, Isoprene, lcsh:Physics, 0105 earth and related environmental sciences
Abstract: The GoAmazon 2014/5 field campaign took place in Manaus, Brazil, and allowed the investigation of the interaction between background-level biogenic air masses and anthropogenic plumes. We present in this work a box model built to simulate the impact of urban chemistry on biogenic secondary organic aerosol (SOA) formation and composition. An organic chemistry mechanism is generated with the Generator for Explicit Chemistry and Kinetics of Organics in the Atmosphere (GECKO-A) to simulate the explicit oxidation of biogenic and anthropogenic compounds. A parameterization is also included to account for the reactive uptake of isoprene oxidation products on aqueous particles. The biogenic emissions estimated from existing emission inventories had to be reduced to match measurements. The model is able to reproduce ozone and NOx for clean and polluted situations. The explicit model is able to reproduce background case SOA mass concentrations but does not capture the enhancement observed in the urban plume. The oxidation of biogenic compounds is the major contributor to SOA mass. A volatility basis set (VBS) parameterization applied to the same cases obtains better results than GECKO-A for predicting SOA mass in the box model. The explicit mechanism may be missing SOA-formation processes related to the oxidation of monoterpenes that could be implicitly accounted for in the VBS parameterization.
Published: 2020

8. Hydrogels based on ozonated cassava starch: Effect of ozone processing and gelatinization conditions on enhancing 3D-printing applications

Author: Patricia Le-Bail, Manoel Divino da Matta Junior, Pedro Esteves Duarte Augusto, Alain Le-Bail, Bianca Chieregato Maniglia, Dâmaris Carvalho Lima, Matrices Aliments Procédés Propriétés Structure - Sensoriel (GEPEA-MAPS2), Laboratoire de génie des procédés - environnement - agroalimentaire (GEPEA), Institut Universitaire de Technologie - Nantes (IUT Nantes), Université de Nantes (UN)-Université de Nantes (UN)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Institut Universitaire de Technologie Saint-Nazaire (IUT Saint-Nazaire), Université de Nantes (UN)-Ecole Polytechnique de l'Université de Nantes (EPUN), Université de Nantes (UN)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut Universitaire de Technologie - La Roche-sur-Yon (IUT La Roche-sur-Yon), Université de Nantes (UN)-Institut Universitaire de Technologie - Nantes (IUT Nantes), Université de Nantes (UN), Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de la Recherche Agronomique (INRA), Universidade de São Paulo = University of São Paulo (USP), Institut de biologie structurale et microbiologie (IBSM), Université de la Méditerranée - Aix-Marseille 2-Université Paul Cézanne - Aix-Marseille 3-Université de Provence - Aix-Marseille 1-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Food and Nutrition Research Center (NAPAN), CCSD, Accord Elsevier, Université de Nantes (UN)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), and University of São Paulo (USP)
Subjects: Manihot, Ozone, [SPI] Engineering Sciences [physics], [SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering, Starch, 02 engineering and technology, Starch modification, Biochemistry, OXIDAÇÃO COM OZÔNIO, [SPI]Engineering Sciences [physics], 03 medical and health sciences, chemistry.chemical_compound, Molecular size, Structural Biology, Oxidation, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, Molecular Biology, 030304 developmental biology, Cassava starch, 0303 health sciences, Chemistry, Temperature, food and beverages, Hydrogels, 3D printing, General Medicine, Apparent viscosity, 021001 nanoscience & nanotechnology, Environmentally friendly, Process conditions, Molecular Weight, Chemical engineering, Printing, Three-Dimensional, Self-healing hydrogels, 0210 nano-technology
Abstract: Ozone is an interesting alternative for modifying starch, as it is considered an emerging and environmentally friendly technology. New applications for food ingredients are receiving attention, such as 3D printing. Consequently, the impact of emerging technologies on new applications must be understood. In this work, cassava starch was modified by ozone to evaluate its printability. Increasing ozonation time produced a starch with higher carbonyl and carboxyl contents, lower pH and molecular size, and gels with different behaviors (stronger and weaker than the native ones, as a function of processing time). The hydrogels obtained were evaluated in relation to pasting and gel properties, including their printability. The effects of starch concentration, gelatinization temperature and storage period were also evaluated. Starch ozonated for 30 min showed the lowest peak apparent viscosity at all the temperatures and starch concentrations evaluated, and provided the strongest gel. Gels produced by native starches and starches ozonated for 30 min showed good printability when the gelatinization temperature used was 65 °C, but up to this temperature, only starch ozonated for 30 min produced gels with good printability. This work highlights that, by using the ozone process to modify starch and varying the process conditions, it is possible to obtain hydrogels with enhanced pasting properties, gel texture, and printability, thereby expanding the potential of starch applications.
Published: 2019

9. Future changes to the upper ocean Western Boundary Currents across two generations of climate models

Author: Vincent Rossi, Annette Stellema, Adriana Vergés, Andréa S. Taschetto, Alex Sen Gupta, Gabriel M. Pontes, University of New South Wales [Sydney] (UNSW), University of São Paulo (USP), Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN), ANR-17-MART-0001,SEAMoBB,Solutions for sEmi-Automated Monitoring of Benthic Biodiversity(2017), ANR-20-BFOC-0006,OceanFrontCHANGE,Managing Ocean Front Ecosystems for Climate Change(2020), Universidade de São Paulo = University of São Paulo (USP), and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0106 biological sciences, 010504 meteorology & atmospheric sciences, Science, [SDE.MCG]Environmental Sciences/Global Changes, Subtropics, Physical oceanography, 010603 evolutionary biology, 01 natural sciences, Article, 14. Life underwater, Climate and Earth system modelling, 0105 earth and related environmental sciences, Marine biology, [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, Throughflow, Multidisciplinary, Ocean current, Climate-change ecology, Boundary current, Gulf Stream, Current (stream), 13. Climate action, Climatology, Environmental science, Medicine, Climate model, Climate-change impacts
Abstract: Western Boundary Currents (WBCs) are important for the oceanic transport of heat, dissolved gases and nutrients. They can affect regional climate and strongly influence the dispersion and distribution of marine species. Using state-of-the-art climate models from the latest and previous Climate Model Intercomparison Projects, we evaluate upper ocean circulation and examine future projections, focusing on subtropical and low-latitude WBCs. Despite their coarse resolution, climate models successfully reproduce most large-scale circulation features with ensemble mean transports typically within the range of observational uncertainty, although there is often a large spread across the models and some currents are systematically too strong or weak. Despite considerable differences in model structure, resolution and parameterisations, many currents show highly consistent projected changes across the models. For example, the East Australian Current, Brazil Current and Agulhas Current extensions are projected to intensify, while the Gulf Stream, Indonesian Throughflow and Agulhas Current are projected to weaken. Intermodel differences in most future circulation changes can be explained in part by projected changes in the large-scale surface winds. In moving to the latest model generation, despite structural model advancements, we find little systematic improvement in the simulation of ocean transports nor major differences in the projected changes.
Published: 2021

10. Mitochondria as a Cellular Hub in Infection and Inflammation

Author: Pauline Andrieux, Christophe Chevillard, Edecio Cunha-Neto, João Paulo Silva Nunes, Theories and Approaches of Genomic Complexity (TAGC), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of São Paulo (USP), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), and Universidade de São Paulo = University of São Paulo (USP)
Subjects: QH301-705.5, Cell, Inflammation, Review, Oxidative phosphorylation, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Mitochondrion, Biology, Infections, Mitochondrial Dynamics, Catalysis, Proinflammatory cytokine, mitochondrial bioenergetics, Inorganic Chemistry, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Organelle, medicine, Animals, Humans, mitochondria dysfunction, Physical and Theoretical Chemistry, Biology (General), Molecular Biology, QD1-999, Spectroscopy, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Reactive oxygen species, Organic Chemistry, General Medicine, infection, 3. Good health, Computer Science Applications, Cell biology, inflammatory disease, mitochondria, Chemistry, medicine.anatomical_structure, chemistry, Cytoplasm, inflammation, infection disease, medicine.symptom, Energy Metabolism, 030217 neurology & neurosurgery
Abstract: International audience; Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as dynamic networks where they adapt energy production based on the cell’s needs. They are also at the center of the proinflammatory response and have essential roles in the response against pathogenic infections. Mitochondria are a major site for production of Reactive Oxygen Species (ROS; or free radicals), which are essential to fight infection. However, excessive and uncontrolled production can become deleterious to the cell, leading to mitochondrial and tissue damage. Pathogens exploit the role of mitochondria during infection by affecting the oxidative phosphorylation mechanism (OXPHOS), mitochondrial network and disrupting the communication between the nucleus and the mitochondria. The role of mitochondria in these biological processes makes these organelle good targets for the development of therapeutic strategies. In this review, we presented a summary of the endosymbiotic origin of mitochondria and their involvement in the pathogen response, as well as the potential promising mitochondrial targets for the fight against infectious diseases and chronic inflammatory diseases.
Published: 2021

11. Glass forming regions, structure and properties of lanthanum barium germanate and gallate glasses

Author: Marc Dussauze, Véronique Jubera, Florian Calzavara, Thierry Cardinal, Marcelo Nalin, Evelyne Fargin, Mathieu Allix, Université de Bordeaux, 1 Avenue de la Recherche Scientifique, 351 cours de la Libération, Universidade Estadual Paulista (UNESP), Institut de Chimie de la Matière Condensée de Bordeaux (ICMCB), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Conditions Extrêmes et Matériaux : Haute Température et Irradiation (CEMHTI), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université d'Orléans (UO), Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institute of Chemistry [University of São Paulo] | Instituto de Química [Universidade de São Paulo], University of São Paulo (USP), This research was supported by Agence Nationale de la Recherche (ANR) (ANR-18-CE08-0004-02) and the New Aquitaine Region. This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 823941 (FUNGLASS), as well as grants of the Agence Nationale de la Recherche (ANR) with the program 'Investissement d'avenir' number ANR-10-IDEX-03-02. M. Nalin acknowledge the São Paulo Research Foundation, FAPESP (grant numbers 2013/07793-6 and 2019/01223-0). The authors acknowledge the platform SIV for vibrational spectroscopy characterizations., ANR-10-IDEX-0003,IDEX BORDEAUX,Initiative d'excellence de l'Université de Bordeaux(2010), ANR-18-CE08-0004,FLAG-IR,Fabrication 3D de composants optiques intégrés à bas cout par laser femtoseconde pour des applications IR(2018), European Project: 664440,H2020,H2020-WIDESPREAD-2014-1,FunGLASS(2015), Institute of Chemistry, University of São Paulo, Université d'Orléans (UO)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1 (UB)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Universidade de São Paulo = University of São Paulo (USP)
Subjects: Materials science, Vibrational Infrared and Raman spectroscopies, Germano-gallate glasses, chemistry.chemical_element, Germanium, 02 engineering and technology, 01 natural sciences, Aerodynamic levitation, 010309 optics, Glass structure, symbols.namesake, 0103 physical sciences, Materials Chemistry, Lanthanum, Germanate, Gallium, Aerodynamic levitation coupled to laser heating, Barium, Gallate, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, chemistry, Heavy-metal oxide glasses, Ceramics and Composites, symbols, Physical chemistry, 0210 nano-technology, Raman spectroscopy
Abstract: Made available in DSpace on 2022-04-28T19:41:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Horizon 2020 Framework Programme Agence Nationale de la Recherche Glass forming regions in the system GaO3/2 – GeO2 – LaO3/2 – BaO have been explored using aerodynamic levitation coupled to laser heating synthesis technique. Structure property relationships have been established between the thermal and optical properties of the resulting glass thanks to Raman and Infrared vibrational spectroscopies. The germano-gallate glass networks are mainly made of three-dimensional interconnected corner shared GeO4 and GaO4 tetrahedra forming Ge – O – Ge and Ga – O− – Ge bridges in which gallium tetrahedral GaO4 units are charged-compensated by barium and lanthanum cations. In GeO2-rich compositions, the excess of positive charges produces mainly non-bridging oxygens on germanate moieties, leading to a depolymerization of the glass network. In the case of gallium rich compositions, the infrared cut-off is red-shifted as compared to the germanate glasses, in accordance with the disappearance of germanium associated entities such as germanium and gallium bridges or germanium sites with non-bridging oxygen both vibrating at higher wavenumber. Institut de Chimie de la Matière Condensée de Bordeaux Université de Bordeaux, 87 Avenue du Dr Schweitzer Conditions Extrêmes et Matériaux Haute Température et Irradiation UPR3079 Université d'Orléans 1 Avenue de la Recherche Scientifique Institut des Sciences Moléculaires UMR 5255 Université́ de Bordeaux 351 cours de la Libération Institute of Chemistry São Paulo State University-UNESP Rua Prof. Francisco Degni, 55, CEP 14800-060 Institute of Chemistry São Paulo State University-UNESP Rua Prof. Francisco Degni, 55, CEP 14800-060 FAPESP: 2013/07793-6 FAPESP: 2019/01223-0 Horizon 2020 Framework Programme: 823941 Agence Nationale de la Recherche: ANR-10-IDEX-03-02 Agence Nationale de la Recherche: ANR-18-CE08-0004-02
Published: 2021

12. Short-Term Ambient Temperature Forecasting for Smart Heaters

Author: Danilo Carastan-Santos, Anderson Andrei Da Silva, Alfredo Goldman, Angan Mitra, Yanik Ngoko, Clement Mommessin, Denis Trystram, Instituto de Informática da UFRGS (UFRGS), Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS), Data Aware Large Scale Computing (DATAMOVE ), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'Informatique de Grenoble (LIG), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Institute of Mathematics ans Statistics [Sao Paulo], University of São Paulo (USP), Qarnot Computing [Montrouge], University of Leeds, ANR-19-P3IA-0003,MIAI,MIAI @ Grenoble Alpes(2019), and Universidade de São Paulo = University of São Paulo (USP)
Subjects: 13. Climate action, [INFO]Computer Science [cs], 7. Clean energy
Abstract: Maintaining Cloud data centers is a worrying challenge in terms of energy efficiency. This challenge leads to solutions such as deploying Edge nodes that operate inside buildings without massive cooling systems. Edge nodes can act assmart heaters by recycling their consumed energy to heat these buildings. We propose a novel technique to perform temperature forecasting for Edge Computing smart heater environments. Our approach uses time series algorithms to exploit historical air temperature data with smart heaters’ power consumption and heat-sink temperatures to create models to predict short-term ambient temperatures. We implemented our approach on top of Facebook’s Prophet time series forecasting framework, and we used the real-time logs from Qarnot Computing as a usecase of a smart heater Edge platform. Our best trained model yields ambient temperature forecasts with less than 2.66% Mean Absolute Percentage Error showing the feasibility of near realtime forecasting.
Published: 2021

13. The Chemically-Modified Tetracycline COL-3 and Its Parent Compound Doxycycline Prevent Microglial Inflammatory Responses by Reducing Glucose-Mediated Oxidative Stress

Author: Nour Francis, Rosana Chehín, Bruno Figadère, Rita Raisman-Vozari, Paola Ramirez, Florencia González-Lizárraga, Paula Martorell, Patrick P. Michel, Nilson Carlos Ferreira Junior, Maurício dos Santos Pereira, Elaine Aparecida Del Bel, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), University of São Paulo (USP), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), Biomolécules : Conception, Isolement, Synthèse (BioCIS), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Universidade de São Paulo = University of São Paulo (USP), and Gestionnaire, HAL Sorbonne Université 5
Subjects: Lipopolysaccharide, Neuroimmunomodulation, QH301-705.5, glucose metabolism, Fluorescent Antibody Technique, microglia, Oxidative phosphorylation, macromolecular substances, Pharmacology, medicine.disease_cause, Article, neuroinflammation, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Microscopy, Electron, Transmission, medicine, Animals, oxidative stress, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Biology (General), Cells, Cultured, COL-3, 030304 developmental biology, Doxycycline, 0303 health sciences, NADPH oxidase, biology, Microglia, Chemistry, General Medicine, FARMACOLOGIA EXPERIMENTAL, tetracyclines, equipment and supplies, 3. Good health, Respiratory burst, Glucose, medicine.anatomical_structure, Apocynin, biology.protein, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], 030217 neurology & neurosurgery, Oxidative stress, Signal Transduction, medicine.drug
Abstract: We used mouse microglial cells in culture activated by lipopolysaccharide (LPS) or α-synuclein amyloid aggregates (αSa) to study the anti-inflammatory effects of COL-3, a tetracycline derivative without antimicrobial activity. Under LPS or αSa stimulation, COL-3 (10, 20 µM) efficiently repressed the induction of the microglial activation marker protein Iba-1 and the stimulated-release of the pro-inflammatory cytokine TNF-α. COL-3′s inhibitory effects on TNF-α were reproduced by the tetracycline antibiotic doxycycline (DOX, 50 µM), the glucocorticoid dexamethasone, and apocynin (APO), an inhibitor of the superoxide-producing enzyme NADPH oxidase. This last observation suggested that COL-3 and DOX might also operate themselves by restraining oxidative stress-mediated signaling events. Quantitative measurement of intracellular reactive oxygen species (ROS) levels revealed that COL-3 and DOX were indeed as effective as APO in reducing oxidative stress and TNF-α release in activated microglia. ROS inhibition with COL-3 or DOX occurred together with a reduction of microglial glucose accumulation and NADPH synthesis. This suggested that COL-3 and DOX might reduce microglial oxidative burst activity by limiting the glucose-dependent synthesis of NADPH, the requisite substrate for NADPH oxidase. Coherent with this possibility, the glycolysis inhibitor 2-deoxy-D-glucose reproduced the immunosuppressive action of COL-3 and DOX in activated microglia. Overall, we propose that COL-3 and its parent compound DOX exert anti-inflammatory effects in microglial cells by inhibiting glucose-dependent ROS production. These effects might be strengthened by the intrinsic antioxidant properties of DOX and COL-3 in a self-reinforcing manner.
Published: 2021
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14. Intense biogeochemical iron cycling revealed in Neoarchean micropyrites from stromatolites

Author: Johanna Marin-Carbonne, Christophe Thomazo, Nicolas Olivier, Marie-Noëlle Decraene, Pascal Philippot, Etienne Deloule, Harald Strauss, Institut des sciences de la terre [Lausanne] (ISTE), Université de Lausanne (UNIL), Centre de Recherches Pétrographiques et Géochimiques (CRPG), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Biogéosciences [UMR 6282] [Dijon] (BGS), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Laboratoire Magmas et Volcans (LMV), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement et la société-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Géosciences Montpellier, Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Université des Antilles (UA)-Centre National de la Recherche Scientifique (CNRS), University of São Paulo (USP), Westfälische Wilhelms-Universität Münster (WWU), Université de Lausanne = University of Lausanne (UNIL), Biogéosciences [UMR 6282] (BGS), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Universidade de São Paulo = University of São Paulo (USP), and Westfälische Wilhelms-Universität Münster = University of Münster (WWU)
Subjects: Biogeochemical cycle, 010504 meteorology & atmospheric sciences, Archean, Geochemistry, engineering.material, Iron respiration, 010502 geochemistry & geophysics, 01 natural sciences, Early life, Sedimentary depositional environment, δ34S, Stromatolites, [SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, Geochemistry and Petrology, 14. Life underwater, Microbial mat, 0105 earth and related environmental sciences, Chemistry, Iron isotopes, Ion microprobe, Diagenesis, Tumbiana Formation, 13. Climate action, engineering, Sedimentary rock, Pyrite
Abstract: International audience; Iron isotope compositions of sedimentary pyrites (FeS2) are used to constrain the redox evolution of the Precambrian ocean and early Fe-based metabolisms such as Dissimilatory Iron Reduction (DIR). Sedimentary pyrites can record biotic and abiotic iron reduction, which have similar ranges of Fe isotopic fractionation, as well as post-depositional histories and metamorphic overprints that can modify Fe isotope compositions. However, some exceptionally well-preserved sedimentary records, such as the stromatolite-bearing Tumbiana Formation (ca. 2.7 Ga, Western Australia) have been proven to retain primary information on Early Neoarchean microbial ecosystems and associated metabolic pathways. Here, we present in situ Fe isotope measurements of micropyrites included in four stromatolites from the Tumbiana Formation in order to assess iron respiration metabolism using Fe isotope signatures. A set of 142 micropyrites has been analyzed in three lamina types, i.e. micritic, organic-rich and fenestral laminae, by Secondary Ion Mass Spectrometry (SIMS), using a Hyperion radio-frequency plasma source. The diversity of laminae is attributed to specific depositional environments, leading to the formation of Type 1 (micritic laminae) and Type 2 (organic-rich laminae) and early diagenetic effects (Type 3, fenestral laminae). Type 1 and 2 laminae preserved comparable δ56Fe ranges, respectively from −1.76‰ to +4.15‰ and from −1.54‰ to +4.44‰. Type 3 laminae recorded a similar range, although slightly more negative δ56Fe values between −2.20‰ and +2.65‰. Globally, our data show a large range of δ56Fe values, from −2.20‰ to +4.44‰, with a unimodal distribution that differs from the bimodal distribution previously reported in the Tumbiana stromatolites. Such a large range and unimodal distribution cannot be explained by a unique process (e.g., biotic/abiotic Fe reduction or pyrite formation only controlled by the precipitation rate). It rather could reflect a two-step iron cycling process in the sediment pore water including i) partial Fe oxidation forming Fe(OH)3 with positive δ56Fe values followed by ii) partial, possibly microbially induced, Fe reduction leading to Fe2+ availability for pyrite formation by sulfate reducers carrying both negative δ56Fe and δ34S signatures. In this model, the buildup and subsequent reduction through time of a residual Fe(OH)3 reservoir arising from the activity of methanotrophs, can explain the strongly positive δ56FeFe(OH)3 values up to 4‰. These results indicate that Archean microbial mats have been the site of the interaction of several closely linked biogeochemical cycles involving Fe, S and C.
Published: 2021

15. A global metagenomic map of urban microbiomes and antimicrobial resistance

Author: Nadine Farhat, Tomoki Takeda, Astred Castro, Ken McGrath, Khaliun Sanchir, Iman Hajirasouliha, Eunice So, Laraib Zafar, Diana N. Nunes, Harun Mustafa, Amy Zhang, Priscilla Lisboa, Christian Schori, Marisano James, Jasna Chalangal, Sebastien Halary, Shahryar Rana, Yunmi Lee, Oli Schacher, Liliana Godoy, David A. Coil, Phanthira Pugdeethosal, Michelle D. Williams, German Marchandon, Angela Cantillo, Naoya Takahashi, Christopher Mozsary, Juana Gonzalez, Patrick K. H. Lee, Gerardo de Lamotte, Alessandro Robertiello, Steven Du, Fabienne Velter, Stefan G. Stark, Miguel Carbajo, Vincent Matthys, David A. Westfall, Julia Boeri, Irène Mauricette Mendy, Jonathan Cedillo, Francesco Oteri, Robert W. Crawford, Takayuki Ito, Tina Wunderlin, Maureen Muscat, David Paez-Espino, Carmen Urgiles, Aida Nesimi, Steffen Schaaf, Adan Ramirez-Rojas, Kunihiko Miyake, Christopher E. Mason, Anais Cardenas, Sharah Islam, Diego Benítez, Melissa Pool Pizzi, Kianna Ciaramella, Ciro Borrelli, Riham Islam, Dorottya Nagy-Szakal, Abd-Manaaf Bakere, Ait-hamlat Adel, Olha Lakhneko, Badamnyambuu Iderzorig, Ana Valeria Castro, Adam Phillips, Robert A. Petit, Flavia Corsi, Romain Conte, Krista Ryon, Soojin Jang, Joseph Benson, Fernanda de Souza Gomes Kehdy, Cindy Wang, Nicole Mathews, Jenn-Wei Chen, Rachel Paras, Paulina Pastuszek, Abigail Lyons, Paul Roldán, Muntaha Munia, Pierre Nicolas, Cassie L. Ettinger, Kyrylo Pyrshev, Katterinne N. Mendez, Eduardo Castro-Nallar, Valeriia Dotsenko, Michelle Tuz, Krizzy Mallari, Eileen Png, Yuya Sonohara, Tanja Miketic, Stéphane Delmas, Shu Zhang, Masaki Sato, Yuanting Zheng, Jifeng Zhu, Roland Häusler, Lucie Bittner, Savlatjon Rahmatulloev, Jonathan Foox, Bruno D'Alessandro, Alketa Plaku, Faisal Alquaddoomi, Yang Zhang, Kern Rei Chng, Juliana Lago, Allaeddine Chettouh, Tamera Henry, Houtan Noushmehr, Tranette Gregory, Sara Abdul Majid, Frank J. Kelly, Benjamin Pulatov, Laurie Casalot, Takema Kajita, Lennard Epping, Thais Fernanda Bartelli, Eftar Moniruzzaman, Renee Vivancos-Koopman, Thirumalaisamy P. Velavan, Tracy W. Liu, Yelyzaveta Tymoshenko, Alma Plaku, Nika Gurianova, Ambar Mendez, Anna Tomaselli, Sonia Dorado, Donato Giovannelli, Hira Choudhry, Synti Ng, Sheelta S. Kumar, Jennifer Q. Lu, Weijun Liang, Ellen Koag, Dennis Gankin, Maria João Amorim, Gwenola Simon, Kiyoshi Suganuma, Mikhail Karasikov, Christos A. Ouzounis, Madelyn May, Eran Elhaik, Stephan Ossowski, Kevin Bolzli, Matthew Arthur, Yuya Oto, Jananan Pathmanathan, Salah Mahmoud, Kou Takahashi, Brunna Marques, Kelly French, Felipe Sepúlveda, Shusei Yoshikawa, Paulo Thiago de Souza Santos, Andrew N. Gray, Juliana S Bernardes, Felipe Segato, Björn Brindefalk, George C. Yeh, Jhovana L. Velasco Flores, Jill Sullivan, Silva Baburyan, Denisse Flores, Russell Y. Neches, Sabrina Persaud, Rasheena Wright, Takumi Togashi, Verónica Antelo, Nao Kato, Skye Felice, Tatjana Mustac, Daisy Donnellan, Katerine Carrillo, Anna Litskevitch, Catalina García, Sota Ito, Naya Eady, Andrew Wan, Irene Meng, Sophie Guasco, Danilo Ercolini, Francesca De Filippis, Vincent Lemaire, Luice Fan, Lothar H. Wieler, Mariia Rybak, Jorge Sanchez, Jonathan S. Gootenberg, Itsuki Tomita, Maritza S Mosella, Laura Garcia, Natalka Makogon, Daisy Cheung, Hitler Francois Vasquez Arevalo, Freddy Asenjo, Gabriela P. Branco, Erika Cifuentes, Chloé Dequeker, Aspassia D. Chatziefthimiou, Alexis Terrero, Roy Meoded, Isabelle de Oliveira Moraes, Shaleni K. Singh, Orgil-Erdene Molomjamts, Karishma Miah, Laurent David, Wolfgang Haehr, Dao Phuong Giang, Romain Lannes, Prashanthi Ratnanandan, Ryota Yamanaka, Riccardo Vicedomini, Sadaf Ayaz, Oluwatosin M. Osuolale, Laura E. Vann, Gregory Chem, Andrea Gonzalez, Aszia Burrell, Ariel Chernomoretz, Sakura Ishizuka, Michelle Rivera, Avigdor Nosrati, Michelle B. Chen, Juliette Auvinet, Nils Ordioni, Tomoro Warashina, Guillaume Blanc, Tomislav Ivankovic, Christina Black, Lauren E. Hittle, David Hess-Homeier, Michael Kozhar, Hamood Suliman, Karobi Moitra, Saher Rahiel, Spyridon Gkotzis, Jenny Arevalo, Shaikh B. Iqbal, Beth Mutai, Mohammed Mohsin, Scott Tighe, Sylvie Collin, Yoshitaka Saito, Wayne Menary, Youping Deng, Lucy Lee, Esmeralda Jiminez, Ayuki Watanabe, Nikos C. Kyrpides, Natasha Mohan, Angelika Pupiec, Dedan Githae, Simone Cawthorne, Jonathan A. Eisen, Tomoki Iwashiro, Chiaki Homma, Thomas Saw Aung, Laura Molina, Marcus H. Y. Leung, Ophélie Da Silva, Yan Ling Wong, Hosna Noorzi, Mario Moreno, Alina Butova, Leming Shi, Brian W. Wong, Sarah S. Jackson, Moses Lin, Annabelle Meagher, Pujita Das, Catherine Burke, Mitsuki Ota, Maria Domenica Moccia, Nicolas Sprinsky, Catherine E. Pugh, David C. Green, Fazlina Fauzi, Erdenetsetseg Batdelger, Annie Geiger, Valeria Ventorino, Tolulope Oluwadare, Delisia Cuebas, Catalina Truong, Leonardo Posada, Michael Angelov, Tathiane M. Malta, Amanda Ng, Francesca Nadalin, Arya Hawkins-Zafarnia, Yuh Shiwa, Athena Mitsios, Milton Ozório Moraes, Manolo Laiola, Kalyn Ali, Jaden J.A. Hastings, Ikuto Saito, Maheen Shakil, Chisato Suzuki, Elena M. Vayndorf, Hubert Rehrauer, Ajay Menon, Kaitlan Russell, Aliyah Shari, Rebecca Smith, Gregorio Iraola, Max Priestman, Alan Briones, Silver A. Wolf, Camila Gonzalez-Poblete, Eleonora De Lazzari, Shirley Chiu, Michelle Ki, Irene Hoxie, Marianne Jaubert, Ayantu Jinfessa, Ryan J. King, Nghiem Xuan Hoan, Jalia Bynoe, Jacob Friedman, Aneisa Ramcharan, Pablo Fresia, Cristina Muñoz, Muhammad Afaq, Anyi Tang, Médine Benchouaia, Isabella Kuniko T. Takenaka, Anastasia Chasapi, Areeg Naeem, Hannah Benisty, Cecilia N. Cossio, Nathalie Hüsser, Mahfuza Sabina, Thais S. Sabedot, JoAnn Jacobs, Camila P. E. de Souza, Manuela Oliveira, Jean-Pierre Bouly, Mariko Usui, Wilson Miranda, Natalia Marciniak, Hiram Caballero, Samuel Weekes, Alexandra B. Graf, Emily Leong, Tatyana Nikolayeva, Dominique Thomas, Charlotte Greselle, Cecilia Salazar, Sreya Ray Chaudhuri, Kevin Becher, Sandra Roth, Ryusei Miura, Kari Oline Bøifot, Dimitri Manoir, Oliver Toth, Chandrima Bhattacharya, Manuel Perez, Isha Lamba, Takafumi Tsurumaki, Timothy D. Read, Anna-Lena M. Schinke, Ryan Sankar, Le Huu Song, Narasimha Rao Nedunuri, Emmanuel Dias-Neto, Ana Flávia Costa, Adiell Melamed, Christelle Desnues, Natalie R. Davidson, Aaron E. Darling, Hyung Jun Kim, Josephine Galipon, Jacqueline Orrego, Dimitar Vassilev, Michael Huber, Nur Hazlin Hazrin-Chong, Gaston H. Gonnet, Kaymisha Knights, Osman U. Sezerman, Dmitry Meleshko, Eunice Thambiraja, Jingcheng Yang, Aubin Fleiss, Gloria Nguyen, Katelyn Jackson, Nuria Aventin, Stephanie L. Hyland, Andrea Hässig, Catharine Aquino, Simona Lysakova, Israel O. Osuolale, Kasia Sluzek, Rania Siam, Alina Frolova, Samuel Hernandez, Yui Him Lo, Bazartseren Boldgiv, Ben Young, Maryna Korshevniuk, Majelia Ampadu, Yuk Man Tang, Amanda L. Muehlbauer, Sade Thomas, Gabriel Figueroa, Alexis Rivera, Lisbeth Pineda, Alexandra Dutan, Jennifer M. Tran, Chris K. Deng, Vedbar S. Khadka, Paola Florez de Sessions, Elizabeth Humphries, Hugues Richard, Hiba Naveed, Nora C. Toussaint, Mahshid Khavari, Maria del Mar Vivanco Ruiz, Antonin Thiébaut, Nicolás Rascovan, Marius Dybwad, Orhan Özcan, Lawrence Kwong, David Danko, Shaira Khan, Andrea Tassinari, Silvia Beurmann, Tsoi Ying Lai, Nanami Kubota, Tieliu Shi, Diana Chicas, Evan E. Afshin, Hirokazu Yano, Jonas Krebs, Mayuko Nakagawa, Hyun Jung Lee, Irene González Navarrete, Rachid Ounit, Lucia E. Alvarado-Arnez, Masaki Nasu, Allison Chan, Harilanto Andrianjakarivony, Jennifer Amachee, Mahdi Taye, Wan Chiew Ng, Kathryn O’Brien, Shino Ishikawa, Tristan Bitard-Feildel, Sora Takagi, Felix Hartkopf, Niamh B. O’Hara, Marcos A. S. Fonseca, Subhamitra Pakrashi, Amrit Kaur, Eva Hell, Patricia Vera-Wolf, Naimah Munim, Luiza Ferreira de Araújo, Mizuki Igarashi, Brianna Pompa-Hogan, Alessandra Carbone, Anne-Sophie Benoiston, Eric Helfrich, Michael A. Suarez-Villamil, Omar O. Abudayyeh, Natasha Abdullah, Jaime J. Fuentes, Juan Carlos Forero, Tetiana Yeskova, Denis Bertrand, Sambhawa Priya, Denisse Maldonado, Agier Nicolas, Ana Valeria B Castro, Starr Chatziefthimiou, André Kahles, Aaishah Francis, Fernanda Arredondo, Emilio Tarcitano, Irvind Buttar, Alex Alexiev, Jennifer Molinet, Sarah Shalaby, Itunu A. Oluwadare, Jason Sperry, Katrin Bakhl, Ana M. Cañas, Sofia Ahsanuddin, Miar Elaskandrany, Elodie Laine, Sven Bönigk, Johannes Werner, Stephen Eduard Boja Ruiz, Gargi Dayama, Paulina Buczansla, Brandon Valentine, Bharath Prithiviraj, Toni Bode, Stas Zubenko, Jake Cohen, Guilllaume Jospin, Zulena Saravi, Per O. Ljungdahl, Inderjit Kaur, Mauricio Moldes, Giuseppe KoLoMonaco, Denise Syndercombe Court, Sonia Bouchard, Sonia Losim, Sookwon Moon, Heba Shaaban, Suraj Patel, Sibo Zhu, Sarh Aly, Arif Asyraf Md Supie, LaShonda Dorsey, Juan Guerra, François Baudon, Rantimi A. Olawoyin, Alexia Bordigoni, Iqra Faiz, Mathilde Garcia, Gabriella Mason-Buck, María Gabriela Portilla, Niranjan Nagarajan, Fumie Takahara, Nancy Merino, Watson Andrew, Gina Kim, Yuma Sato, Hyenah Shim, Marie-Laure Jerier, Affifah Saadah Ahmad Kassim, Katerina Kuchin, Daniel Butler, Paweł P. Łabaj, Nadezhda Kobko-Litskevitch, Emmanuel F. Mongodin, Yuto Togashi, Paula Rodríguez, Pilar Lopez Hernandez, Xiaoqing Chen, Maria A. Sierra, Olga Nikolayeva, Manon Loubens, Colleen Conger, Hikaru Shirahata, Chenhao Li, Timothy Donahoe, Youngja Park, Lucia Elena Alvarado Arnez, Salama Chaker, Francisco Chavez, Alessandra Breschi, Jorge L. Sanchez, Kaung Myat San, Nayra Aguilar Rojas, Marcos Abraao, Kai Sasaki, Bryan Nazario, Olena Yemets, Klas I. Udekwu, Lynn M. Schriml, Anisia Peters, Aliaksei Holik, Mark Hernandez, Emile Faure, Malay Bhattacharyya, Josef W. Moser, Núria Andreu Somavilla, María Mercedes Zambrano, Kannan Rajendran, Gabriela E. Albuquerque, Tao Qing, Kazutoshi Tsuda, Ymke De Jong, Princess Osma, Mayra Arauco Livia, Javier Quilez Oliete, Carl Chrispin, Hyun Woo Joo, Ingrid Lafontaine, Nala An, Seisuke Sato, Felipe Segato Dezem, Andrew Maltez Thomas, Alexandre Desert, Xiao Wen Cai, O. Osuolale, Jun Wu, Coral Pardo-Esté, Courtney Robinson, Yuri Matsuzaki, Marina Nieto-Caballero, Cem Meydan, Ralph Schlapbach, Mark Menor, Sofia Castro, Rachel Kwong, Brittany Blyther, Olexandr Lykhenko, Jason R. Schriml, Christian Brion, Jenessa Orpilla, Juan A. Ugalde, Elsy Mankah Ngwa, Álvaro Aranguren, Lauren Mak, Matías Giménez, Ashanti Narce, Torsten Semmler, Stefan I. Tsonev, Abdollahi Nika, Katherine E. Dahlhausen, Monika Devi, Gunnar Rätsch, Oasima Muner, Carla Bello, Muhammad Al-Fath Amran, Anyelic Rosario, Melissa Ortega, Andrea Patrignani, Ante Peros, Elias McComb, Ryo Sato, Ireen Alam, Clara N. Dias, Soma Tanaka, Dayana Calderon, Ran Blekhman, Mathilde Mignotte, Alicia Boyd, Jochen Hecht, Thomas Neff, Xinzhao Tong, Josue Alicea, Kiara Olmeda, Sonia Marinovic, Carme Arnan, Kohei Ito, Samantha L. Goldman, Marianna S. Serpa, Renee Richer, Kaisei Sato, Jordana M. Silva, Akash Keluth Chavan, Sangwan Kim, Laís Pereira Ferreira, Sophie Vacant, Nowshin Sayara, Haruo Suzuki, Madeline Leahy, Juan C. Severyn, Sierra Vincent, Masaru Tomita, Maliha Mamun, Lucinda B. Davenport, Gabriella Oken, Dagmara Lewandowska, Gustavo Adolfo Malca Salas, Andrii Kuklin, Tyler Wong, Charlie Feigin, Eric Minwei Liu, Sonia L. Ghose, Daniela Bezdan, Antonietta La Storia, Juan P. Escalera-Antezana, Nuno Rufino de Sousa, Samuel M. Gerner, Weill Cornell Medicine [New York], Icahn School of Medicine at Mount Sinai [New York] (MSSM), Genome Institute of Singapore (GIS), Centre for Genomic Regulation [Barcelona] (CRG), Universitat Pompeu Fabra [Barcelona] (UPF)-Centro Nacional de Analisis Genomico [Barcelona] (CNAG), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Lawrence Berkeley National Laboratory [Berkeley] (LBNL), AUTRES, Massachusetts Institute of Technology (MIT), Indian Statistical Institute [Kolkata], University of Minnesota System, Universidad Andrés Bello [Santiago] (UNAB), California State University [Sacramento], University of Naples Federico II, University of Hawaii, Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN), Medical Genomics Group, University College of London [London] (UCL)-UCL Cancer Institute, Norwegian Defence Research Establishment (FFI), Lund University [Lund], Institute of Molecular Biology and Genetics of National Academy of Sciences of Ukraine, University of Vienna [Vienna], King‘s College London, University of Colorado [Boulder], Institut Pasteur de Montevideo, Réseau International des Instituts Pasteur (RIIP), Institut Pasteur Korea - Institut Pasteur de Corée, Fudan University [Shanghai], City University of Hong Kong [Hong Kong] (CUHK), Stockholm University, University of Maryland School of Medicine, University of Maryland System, Fundação Oswaldo Cruz (FIOCRUZ), University of São Paulo (USP), Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Barcelona Institute of Science and Technology (BIST), Elizade University, Acibadem Mehmet Ali Aydınlar University, Paléogénomique microbienne - Microbial paleogenomics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), Robert Koch Institute [Berlin] (RKI), East China Normal University [Shangaï] (ECNU), Cairo University, Vietnamese-German Center for Medical Research, Keio University, Université du Vermont, Universidad del Desarrollo, University of Sofia, University of Alaska [Fairbanks] (UAF), Universitätsklinikum Tübingen - University Hospital of Tübingen, Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Corporación Corpogen-Research Center, Biologie Computationnelle et Quantitative = Laboratory of Computational and Quantitative Biology (LCQB), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Weill Cornell Medicine [Cornell University], Cornell University [New York], University of Naples Federico II = Università degli studi di Napoli Federico II, Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Universidade de São Paulo = University of São Paulo (USP), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Софийски университет = Sofia University, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Universidad Andrés Bello - UNAB (CHILE), Acibadem University Dspace, Danko, D., Bezdan, D., Afshin, E. E., Ahsanuddin, S., Bhattacharya, C., Butler, D. J., Chng, K. R., Donnellan, D., Hecht, J., Jackson, K., Kuchin, K., Karasikov, M., Lyons, A., Mak, L., Meleshko, D., Mustafa, H., Mutai, B., Neches, R. Y., Ng, A., Nikolayeva, O., Nikolayeva, T., Png, E., Ryon, K. A., Sanchez, J. L., Shaaban, H., Sierra, M. A., Thomas, D., Young, B., Abudayyeh, O. O., Alicea, J., Bhattacharyya, M., Blekhman, R., Castro-Nallar, E., Canas, A. M., Chatziefthimiou, A. D., Crawford, R. W., De Filippis, F., Deng, Y., Desnues, C., Dias-Neto, E., Dybwad, M., Elhaik, E., Ercolini, D., Frolova, A., Gankin, D., Gootenberg, J. S., Graf, A. B., Green, D. C., Hajirasouliha, I., Hastings, J. J. A., Hernandez, M., Iraola, G., Jang, S., Kahles, A., Kelly, F. J., Knights, K., Kyrpides, N. C., Labaj, P. P., Lee, P. K. H., Leung, M. H. Y., Ljungdahl, P. O., Mason-Buck, G., Mcgrath, K., Meydan, C., Mongodin, E. F., Moraes, M. O., Nagarajan, N., Nieto-Caballero, M., Noushmehr, H., Oliveira, M., Ossowski, S., Osuolale, O. O., Ozcan, O., Paez-Espino, D., Rascovan, N., Richard, H., Ratsch, G., Schriml, L. M., Semmler, T., Sezerman, O. U., Shi, L., Shi, T., Siam, R., Song, L. H., Suzuki, H., Court, D. S., Tighe, S. W., Tong, X., Udekwu, K. I., Ugalde, J. A., Valentine, B., Vassilev, D. I., Vayndorf, E. M., Velavan, T. P., Wu, J., Zambrano, M. M., Zhu, J., Zhu, S., Mason, C. E., Abdullah, N., Abraao, M., Adel, A. -H., Afaq, M., Al-Quaddoomi, F. S., Alam, I., Albuquerque, G. E., Alexiev, A., Ali, K., Alvarado-Arnez, L. E., Aly, S., Amachee, J., Amorim, M. G., Ampadu, M., Amran, M. A. -F., An, N., Andrew, W., Andrianjakarivony, H., Angelov, M., Antelo, V., Aquino, C., Aranguren, A., Araujo, L. F., Vasquez Arevalo, H. F., Arevalo, J., Arnan, C., Alvarado Arnez, L. E., Arredondo, F., Arthur, M., Asenjo, F., Aung, T. S., Auvinet, J., Aventin, N., Ayaz, S., Baburyan, S., Bakere, A. -M., Bakhl, K., Bartelli, T. F., Batdelger, E., Baudon, F., Becher, K., Bello, C., Benchouaia, M., Benisty, H., Benoiston, A. -S., Benson, J., Benitez, D., Bernardes, J., Bertrand, D., Beurmann, S., Bitard-Feildel, T., Bittner, L., Black, C., Blanc, G., Blyther, B., Bode, T., Boeri, J., Boldgiv, B., Bolzli, K., Bordigoni, A., Borrelli, C., Bouchard, S., Bouly, J. -P., Boyd, A., Branco, G. P., Breschi, A., Brindefalk, B., Brion, C., Briones, A., Buczansla, P., Burke, C. M., Burrell, A., Butova, A., Buttar, I., Bynoe, J., Bonigk, S., Boifot, K. O., Caballero, H., Cai, X. W., Calderon, D., Cantillo, A., Carbajo, M., Carbone, A., Cardenas, A., Carrillo, K., Casalot, L., Castro, S., Castro, A. V., Castro, A., Castro, A. V. B., Cawthorne, S., Cedillo, J., Chaker, S., Chalangal, J., Chan, A., Chasapi, A. I., Chatziefthimiou, S., Chaudhuri, S. R., Chavan, A. K., Chavez, F., Chem, G., Chen, X., Chen, M., Chen, J. -W., Chernomoretz, A., Chettouh, A., Cheung, D., Chicas, D., Chiu, S., Choudhry, H., Chrispin, C., Ciaramella, K., Cifuentes, E., Cohen, J., Coil, D. A., Collin, S., Conger, C., Conte, R., Corsi, F., Cossio, C. N., Costa, A. F., Cuebas, D., D'Alessandro, B., Dahlhausen, K. E., Darling, A. E., Das, P., Davenport, L. B., David, L., Davidson, N. R., Dayama, G., Delmas, S., Deng, C. K., Dequeker, C., Desert, A., Devi, M., Dezem, F. S., Dias, C. N., Donahoe, T. R., Dorado, S., Dorsey, L., Dotsenko, V., Du, S., Dutan, A., Eady, N., Eisen, J. A., Elaskandrany, M., Epping, L., Escalera-Antezana, J. P., Ettinger, C. L., Faiz, I., Fan, L., Farhat, N., Faure, E., Fauzi, F., Feigin, C., Felice, S., Ferreira, L. P., Figueroa, G., Fleiss, A., Flores, D., Velasco Flores, J. L., Fonseca, M. A. S., Foox, J., Forero, J. C., Francis, A., French, K., Fresia, P., Friedman, J., Fuentes, J. J., Galipon, J., Garcia, M., Garcia, L., Garcia, C., Geiger, A., Gerner, S. M., Ghose, S. L., Giang, D. P., Gimenez, M., Giovannelli, D., Githae, D., Gkotzis, S., Godoy, L., Goldman, S., Gonnet, G. H., Gonzalez, J., Gonzalez, A., Gonzalez-Poblete, C., Gray, A., Gregory, T., Greselle, C., Guasco, S., Guerra, J., Gurianova, N., Haehr, W., Halary, S., Hartkopf, F., Hawkins-Zafarnia, A., Hazrin-Chong, N. H., Helfrich, E., Hell, E., Henry, T., Hernandez, S., Hernandez, P. L., Hess-Homeier, D., Hittle, L. E., Hoan, N. X., Holik, A., Homma, C., Hoxie, I., Huber, M., Humphries, E., Hyland, S., Hassig, A., Hausler, R., Husser, N., Petit, R. A., Iderzorig, B., Igarashi, M., Iqbal, S. B., Ishikawa, S., Ishizuka, S., Islam, S., Islam, R., Ito, K., Ito, S., Ito, T., Ivankovic, T., Iwashiro, T., Jackson, S., Jacobs, J., James, M., Jaubert, M., Jerier, M. -L., Jiminez, E., Jinfessa, A., De Jong, Y., Joo, H. W., Jospin, G., Kajita, T., Ahmad Kassim, A. S., Kato, N., Kaur, A., Kaur, I., de Souza Gomes Kehdy, F., Khadka, V. S., Khan, S., Khavari, M., Ki, M., Kim, G., Kim, H. J., Kim, S., King, R. J., Kolomonaco, G., Koag, E., Kobko-Litskevitch, N., Korshevniuk, M., Kozhar, M., Krebs, J., Kubota, N., Kuklin, A., Kumar, S. S., Kwong, R., Kwong, L., Lafontaine, I., Lago, J., Lai, T. Y., Laine, E., Laiola, M., Lakhneko, O., Lamba, I., de Lamotte, G., Lannes, R., De Lazzari, E., Leahy, M., Lee, H., Lee, Y., Lee, L., Lemaire, V., Leong, E., Lewandowska, D., Li, C., Liang, W., Lin, M., Lisboa, P., Litskevitch, A., Liu, E. M., Liu, T., Livia, M. A., Lo, Y. H., Losim, S., Loubens, M., Lu, J., Lykhenko, O., Lysakova, S., Mahmoud, S., Majid, S. A., Makogon, N., Maldonado, D., Mallari, K., Malta, T. M., Mamun, M., Manoir, D., Marchandon, G., Marciniak, N., Marinovic, S., Marques, B., Mathews, N., Matsuzaki, Y., Matthys, V., May, M., Mccomb, E., Meagher, A., Melamed, A., Menary, W., Mendez, K. N., Mendez, A., Mendy, I. M., Meng, I., Menon, A., Menor, M., Meoded, R., Merino, N., Miah, K., Mignotte, M., Miketic, T., Miranda, W., Mitsios, A., Miura, R., Miyake, K., Moccia, M. D., Mohan, N., Mohsin, M., Moitra, K., Moldes, M., Molina, L., Molinet, J., Molomjamts, O. -E., Moniruzzaman, E., Moon, S., de Oliveira Moraes, I., Moreno, M., Mosella, M. S., Moser, J. W., Mozsary, C., Muehlbauer, A. L., Muner, O., Munia, M., Munim, N., Muscat, M., Mustac, T., Munoz, C., Nadalin, F., Naeem, A., Nagy-Szakal, D., Nakagawa, M., Narce, A., Nasu, M., Navarrete, I. G., Naveed, H., Nazario, B., Nedunuri, N. R., Neff, T., Nesimi, A., Ng, W. C., Ng, S., Nguyen, G., Ngwa, E., Nicolas, A., Nicolas, P., Nika, A., Noorzi, H., Nosrati, A., Nunes, D. N., O'Brien, K., O'Hara, N. B., Oken, G., Olawoyin, R. A., Oliete, J. Q., Olmeda, K., Oluwadare, T., Oluwadare, I. A., Ordioni, N., Orpilla, J., Orrego, J., Ortega, M., Osma, P., Osuolale, I. O., Osuolale, O. M., Ota, M., Oteri, F., Oto, Y., Ounit, R., Ouzounis, C. A., Pakrashi, S., Paras, R., Pardo-Este, C., Park, Y. -J., Pastuszek, P., Patel, S., Pathmanathan, J., Patrignani, A., Perez, M., Peros, A., Persaud, S., Peters, A., Phillips, A., Pineda, L., Pizzi, M. P., Plaku, A., Pompa-Hogan, B., Portilla, M. G., Posada, L., Priestman, M., Prithiviraj, B., Priya, S., Pugdeethosal, P., Pugh, C. E., Pulatov, B., Pupiec, A., Pyrshev, K., Qing, T., Rahiel, S., Rahmatulloev, S., Rajendran, K., Ramcharan, A., Ramirez-Rojas, A., Rana, S., Ratnanandan, P., Read, T. D., Rehrauer, H., Richer, R., Rivera, A., Rivera, M., Robertiello, A., Robinson, C., Rodriguez, P., Rojas, N. A., Roldan, P., Rosario, A., Roth, S., Ruiz, M., Boja Ruiz, S. E., Russell, K., Rybak, M., Sabedot, T. S., Sabina, M., Saito, I., Saito, Y., Malca Salas, G. A., Salazar, C., San, K. M., Sanchez, J., Sanchir, K., Sankar, R., de Souza Santos, P. T., Saravi, Z., Sasaki, K., Sato, Y., Sato, M., Sato, S., Sato, R., Sato, K., Sayara, N., Schaaf, S., Schacher, O., Schinke, A. -L. M., Schlapbach, R., Schori, C., Schriml, J. R., Segato, F., Sepulveda, F., Serpa, M. S., De Sessions, P. F., Severyn, J. C., Shakil, M., Shalaby, S., Shari, A., Shim, H., Shirahata, H., Shiwa, Y., Da Silva, O., Silva, J. M., Simon, G., Singh, S. K., Sluzek, K., Smith, R., So, E., Andreu Somavilla, N., Sonohara, Y., Rufino de Sousa, N., Souza, C., Sperry, J., Sprinsky, N., Stark, S. G., La Storia, A., Suganuma, K., Suliman, H., Sullivan, J., Supie, A. A. M., Suzuki, C., Takagi, S., Takahara, F., Takahashi, N., Takahashi, K., Takeda, T., Takenaka, I. K., Tanaka, S., Tang, A., Man Tang, Y., Tarcitano, E., Tassinari, A., Taye, M., Terrero, A., Thambiraja, E., Thiebaut, A., Thomas, S., Thomas, A. M., Togashi, Y., Togashi, T., Tomaselli, A., Tomita, M., Tomita, I., Toth, O., Toussaint, N. C., Tran, J. M., Truong, C., Tsonev, S. I., Tsuda, K., Tsurumaki, T., Tuz, M., Tymoshenko, Y., Urgiles, C., Usui, M., Vacant, S., Vann, L. E., Velter, F., Ventorino, V., Vera-Wolf, P., Vicedomini, R., Suarez-Villamil, M. A., Vincent, S., Vivancos-Koopman, R., Wan, A., Wang, C., Warashina, T., Watanabe, A., Weekes, S., Werner, J., Westfall, D., Wieler, L. H., Williams, M., Wolf, S. A., Wong, B., Wong, Y. L., Wong, T., Wright, R., Wunderlin, T., Yamanaka, R., Yang, J., Yano, H., Yeh, G. C., Yemets, O., Yeskova, T., Yoshikawa, S., Zafar, L., Zhang, Y., Zhang, S., Zhang, A., Zheng, Y., and Zubenko, S.
Subjects: Urban Population, Drug Resistance, Sequence assembly, Microbiologia, microbiome, global health, computer.software_genre, Medical and Health Sciences, shotgun sequencing, BGC, 0302 clinical medicine, Databases, Genetic, 11. Sustainability, Global health, AMR, 11 Medical and Health Sciences, ComputingMilieux_MISCELLANEOUS, 0303 health sciences, built environment, metagenome, antimicrobial resistance, NGS, de novo assembly, biology, Shotgun sequencing, Microbiota, built Environment, Bacterial, Biodiversity, Biological Sciences, 3. Good health, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Infection, Biotechnology, Geospatial analysis, [SDV.BID]Life Sciences [q-bio]/Biodiversity, Article, General Biochemistry, Genetics and Molecular Biology, Databases, 03 medical and health sciences, Antibiotic resistance, Genetic, Drug Resistance, Bacterial, International MetaSUB Consortium, Genetics, Humans, Microbiome, 030304 developmental biology, Human Genome, 06 Biological Sciences, 15. Life on land, biology.organism_classification, Resistènica als medicaments antiinfecciosos, SAÚDE PÚBLICA, Genòmica, 13. Climate action, Evolutionary biology, Metagenomics, Antimicrobial Resistance, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, computer, 030217 neurology & neurosurgery, Archaea, Developmental Biology
Abstract: Summary We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an annotated, geospatial profile of microbial strains, functional characteristics, antimicrobial resistance (AMR) markers, and genetic elements, including 10,928 viruses, 1,302 bacteria, 2 archaea, and 838,532 CRISPR arrays not found in reference databases. We identified 4,246 known species of urban microorganisms and a consistent set of 31 species found in 97% of samples that were distinct from human commensal organisms. Profiles of AMR genes varied widely in type and density across cities. Cities showed distinct microbial taxonomic signatures that were driven by climate and geographic differences. These results constitute a high-resolution global metagenomic atlas that enables discovery of organisms and genes, highlights potential public health and forensic applications, and provides a culture-independent view of AMR burden in cities., Graphical abstract, Highlights • Cities possess a consistent “core” set of non-human microbes • Urban microbiomes echo important features of cities and city-life • Antimicrobial resistance genes are widespread in cities • Cities contain many novel bacterial and viral species, This systematic, worldwide catalog of urban microbiomes represents a metagenomic atlas important for understanding the ecology, virulence, and antibiotic resistance of city-specific microbial communities.
Published: 2021

16. Altered visual processing in the mdx52 mouse model of Duchenne muscular dystrophy

Author: Alvaro Rendon, Anneka Joachimsthaler, Cyrille Vaillend, Jerome E. Roger, Jan Kremers, Dora Fix Ventura, Mirella Telles Salgueiro Barboni, Andre Liber, Amel Saoudi, Aurélie Goyenvalle, Semmelweis University [Budapest], University of São Paulo (USP), Section for Retinal Physiology, University Hospital Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Handicap neuromusculaire : Physiopathologie, Biothérapie et Pharmacologies appliquées (END-ICAP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de la Vision, Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Etudes et de Recherche Thérapeutique en Ophtalmologie (CERTO), Association RETINA France, Partenaires INRAE-Partenaires INRAE, Sction for Retinal Physiology, University Hospital Erlangen, This study was supported by the Centre National de la Recherche Scientifique (CNRS), the Universit ́e Paris-Sud (France), the DIM Gene Therapy Region Ile-de-France to JER, the Deutscher Akademischer Austauschdienst (DAAD #57513929) in Germany and Tempus Public Foundation in Hungary to JK and MTSB, the Sao Paulo Research Foundation (FAPESP # 2019/007771 to AMPL, 2016/04538–3 and 2014/26818–2 to DFV), the National Council for Scientific and Tech-nological Development (CNPq grant number 404239/2016–1 to MTSB), a project award from the Association Mon ́egasque contre les Myopathies (AMM, Monaco) to CV, a National Research, Development, and Inno-vation Fund of Hungary OTKA (PD134799), a fellowship from Campus France (dossier 931,824 L) and a short-term scientific mission from COST Action CA17103 to MTSB and a CNPq 1A productivity fellowship (CNPq 309,409/2015–2) to DFV., PERIGNON, Alain, Universidade de São Paulo = University of São Paulo (USP), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Duchenne muscular dystrophy, Photoreceptors, genetic structures, Mesopic vision, Dp427, media_common.quotation_subject, B-wave, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, Biology, Synaptic Transmission, Retina, lcsh:RC321-571, Mouse model, Dystrophin, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, medicine, Electroretinography, Contrast (vision), Animals, Scotopic vision, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, media_common, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Retinal, Electroretinogram, medicine.disease, Muscular Dystrophy, Duchenne, 030104 developmental biology, Neurology, chemistry, Optomotor response, Mice, Inbred mdx, Visual Perception, Dp260, Dp140, sense organs, Erg, Neuroscience, [SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, 030217 neurology & neurosurgery, Photopic vision
Abstract: International audience; The mdx52 mouse model of Duchenne muscular dystrophy (DMD) is lacking exon 52 of the DMD gene that is located in a hotspot mutation region causing cognitive deficits and retinal anomalies in DMD patients. This deletion leads to the loss of the dystrophin proteins, Dp427, Dp260 and Dp140, while Dp71 is preserved. The flash electroretinogram (ERG) in mdx52 mice was previously characterized by delayed dark-adapted b-waves. A detailed description of functional ERG changes and visual performances in mdx52 mice is, however, lacking. Here an extensive full-field ERG repertoire was applied in mdx52 mice and WT littermates to analyze retinal physiology in scotopic, mesopic and photopic conditions in response to flash, sawtooth and/or sinusoidal stimuli. Behavioral contrast sensitivity was assessed using quantitative optomotor response (OMR) to sinusoidally modulated luminance gratings at 100% or 50% contrast. The mdx52 mice exhibited reduced amplitudes and delayed implicit times in dark-adapted ERG flash responses, particularly in their b-wave and oscillatory potentials, and diminished amplitudes of light-adapted flash ERGs. ERG responses to sawtooth stimuli were also diminished and delayed for both mesopic and photopic conditions in mdx52 mice and the first harmonic amplitudes to photopic sine-wave stimuli were smaller at all temporal frequencies. OMR indices were comparable between genotypes at 100% contrast but significantly reduced in mdx52 mice at 50% contrast. The complex ERG alterations and disturbed contrast vision in mdx52 mice include features observed in DMD patients and suggest altered photoreceptor-to-bipolar cell transmission possibly affecting contrast sensitivity. The mdx52 mouse is a relevant model to appraise the roles of retinal dystrophins and for preclinical studies related to DMD.
Published: 2021

17. Data dictionary cookbook for research data and software interoperability at global scale

Author: Romain David, Laurent Bouveret, Lorraine Coché, Pedro Pizzigatti Corrêa, Rorie Edmunds, Ana Heredia, Jean-Luc Jung, Yasuhisa Kondo, Iwan Le Berre, Yvan Le Bras, Emilie Lerigoleur, Laurence Mabile, Jeaneth Machicao, Bénédicte Madon, Yasuhiro Murayama, Margaret O'Brien, Takeshi Osawa, Hervé Raoul, Audrey Richard, Solange Santos, Alison Specht, Shelley Stall, Diana Stepanyan, Danton Ferreira Vellenich, Lesley Wyborn, European Research Infrastructure on Highly Pathogenic Agents (ERINHA-AISBL), Mathématiques, Informatique et STatistique pour l'Environnement et l'Agronomie (MISTEA), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Observatoire des Mammiferes Marins de l'Archipel Guadeloupeen (OMMAG), Institut Universitaire Européen de la Mer (IUEM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), University of São Paulo (USP), Facultad de Agronomía (E.E.F.A.S), Word Data System, ORCID, Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), RCAST, Littoral, Environnement, Télédétection, Géomatique (LETG - Brest), Littoral, Environnement, Télédétection, Géomatique UMR 6554 (LETG), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (IGARUN), Université de Nantes (UN)-Université de Nantes (UN)-Université de Caen Normandie (UNICAEN), Université de Nantes (UN)-Université de Nantes (UN), Département de Radiologie [Niort] (DR - Niort), CH Niort, Géographie de l'environnement (GEODE), Université Toulouse - Jean Jaurès (UT2J)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, American Geophysical Union, PARSEC is funded by the Belmont Forum through the National Science Foundation (NSF), The São Paulo Research Foundation (FAPESP), the French National Research Agency (ANR), and the Japan Science and Technology Agency (JST). ERINHA Advance is funded by ERINHA-Advance european program under grant agreement Nº824061. Kakila database is funded by the LabEx DRIIHM French program 'Investissements d'Avenir' (ANR-11-LABX-0010) and supported by the SO-DRIIHM project (ANR-19-DATA-0022). This work is partially funded by the EOSC-Life European program (grant agreement No. 824087), ANR-11-LABX-0010,DRIIHM / IRDHEI,Dispositif de recherche interdisciplinaire sur les Interactions Hommes-Milieux(2011), ANR-19-DATA-0022,SO-DRIIHM,Impulser la science ouverte au sein du Dispositif de Recherche Interdisciplinaire sur les Interactions Hommes-Milieux (DRIIHM) : co-design d'une e-infrastructure intégrant les principes FAIR(2019), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Observatoire des Mammiferes Marins de lArchipel Guadeloupeen (OMMAG), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Universidade de São Paulo = University of São Paulo (USP), Muséum national d'Histoire naturelle (MNHN)-École Pratique des Hautes Études (EPHE), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (IGARUN), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), and American Geophysical Union [Washington]
Subjects: [INFO.INFO-DB]Computer Science [cs]/Databases [cs.DB], Data dictionary, cookbook, Research Data Management, Interoperability, reproducibility, FAIR Data, Data Reuse, Data Aggregation, [SDV]Life Sciences [q-bio], Research Data Management, Interoperability, OHM Littoral Caraibe, [SDE.ES]Environmental Sciences/Environmental and Society, Data dictionary, cookbook, FAIR Data, Data Aggregation, [SDV.EE.ECO]Life Sciences [q-bio]/Ecology, environment/Ecosystems, Data Reuse, [INFO.INFO-ET]Computer Science [cs]/Emerging Technologies [cs.ET], [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, 14. Life underwater, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], [SDE.BE]Environmental Sciences/Biodiversity and Ecology, LABEX DRIIHM, reproducibility, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: We are now facing profound changes (biodiversity, climate, pandemic, etc.). Human impacts and their mitigation will depend on our ability to mobilize research at the global level. The sustainable development of the society will largely depend on the sustainable development of global science and scientific research tools, outputs, and research ecosystems. This globalization of research requires interoperating our observation and experimentation systems in order to better understand these changes, to better simulate their effects. The Covid-19 pandemic is now raging around the world. The reproducibility of research and results across regions in different contexts should accelerate human responses. Data sharing and the development of Synthesis Research with data aggregation at large scale is critical to enable such processes. The use of common knowledge, vocabularies, standards and procedures at a large scale is necessary. The objective of this poster is to report on the challenges met while building data dictionaries in three global projects related to biodiversity and/or disease research: PARSEC, Kakila, ERINHA-Advance. The Kakila database centralizes and harmonizes marine mammal observation data for the AGOA sanctuary around the French archipelago of Guadeloupe, French Antilles. The PARSEC Project is building new tools for data sharing and reuse through a transnational investigation of the socioeconomic impact of protected areas. The ERINHA-Advance project aims to support the operations of the ERINHA research infrastructure which is designed to generate data from transnational access research activities on highly pathogenic agents. In these 3 global case-studies, similar challenges have arisen: to aggregate and interoperate pre-existing heterogeneous data at the global scale, and to share common tools to monitor, maintain quality, scan scale and cope with uncertainty. This poster proposes a draft common methodology, a data dictionary cookbook, which will provide a roadmap towards the building of large scale - data dictionaries. Topics proposed to be covered in such a cookbook include: how to search for existing and appropriate data dictionaries, controlled vocabularies or other semantic resources (before building a new one), the first steps for data dictionary building, data dictionary literacy (and why it is a mandatory work), how to define all scientific objects, aspects (or use existing one) and agree on the definitions with the whole community, building / proposing variables / indicators with ontology models, schemas, variables naming rules and context awareness, and finally addressing dimension issues considering each context. The common experience of our three projects showed that we need to proceed step by step as simply as possible and to ensure that each step is understandable for the whole community. It is necessary to improve access and re-use of all existing semantic materials and not trying to build a cathedral with a little spoon.
Published: 2021

18. Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo

Author: Elaine Aparecida Del Bel, Diana F. Lázaro, Nicolas Bizat, Patrick P. Michel, Rosana Chehín, Valeria Parrales, Eftychia Vasili, Antonio Dominguez-Meijide, Tiago F. Outeiro, Annie Lannuzel, Stéphane Haik, Annekatrin König, R. Raisman-Vozari, Florencia González-Lizárraga, University of Göttingen - Georg-August-Universität Göttingen, Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III [Madrid] (ISC), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), CHU Pointe-à-Pitre/Abymes [Guadeloupe], Cellule Nationale de Référence des Maladies de Creutzfeldt-Jakob, CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University of São Paulo (USP), Newcastle University [Newcastle], Gestionnaire, Hal Sorbonne Université, Georg-August-University = Georg-August-Universität Göttingen, Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Cellule Nationale de Référence des Maladies de Creutzfeldt-Jakob [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Universidade de São Paulo = University of São Paulo (USP), Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, and Universidade de Santiago de Compostela. Departamento de Ciencias Morfolóxicas
Subjects: 0301 basic medicine, Parkinson's disease, Synucleinopathies, [SDV]Life Sciences [q-bio], Protein Aggregation, Pathological, Neuroprotection, Cell Line, lcsh:RC321-571, Alpha-synuclein, 03 medical and health sciences, chemistry.chemical_compound, Aggregation, 0302 clinical medicine, In vivo, medicine, Animals, Humans, Caenorhabditis elegans, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Inclusion Bodies, Doxycycline, chemistry.chemical_classification, Reactive oxygen species, medicine.disease, In vitro, 3. Good health, Cell biology, [SDV] Life Sciences [q-bio], Neuroprotective Agents, 030104 developmental biology, Neurology, chemistry, C. elegans, 030217 neurology & neurosurgery, medicine.drug
Abstract: International audience; Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are neurodegenerative disorders characterized by the misfolding and aggregation of alpha-synuclein (aSyn). Doxycycline, a tetracyclic antibiotic shows neuroprotective effects, initially proposed to be due to its anti-inflammatory properties. More recently, an additional mechanism by which doxycycline may exert its neuroprotective effects has been proposed as it has been shown that it inhibits amyloid aggregation. Here, we studied the effects of doxycycline on aSyn aggregation in vivo, in vitro and in a cell free system using real-time quaking induced conversion (RT-QuiC). Using H4, SH-SY5Y and HEK293 cells, we found that doxycycline decreases the number and size of aSyn aggregates in cells. In addition, doxycycline inhibits the aggregation and seeding of recombinant aSyn, and attenuates the production of mitochondrial-derived reactive oxygen species. Finally, we found that doxycycline induces a cellular redistribution of aggregates in a C.elegans animal model of PD, an effect that is associated with a recovery of dopaminergic function. In summary, we provide strong evidence that doxycycline treatment may be an effective strategy against synucleinopathies.
Published: 2021

19. On the Regular Behavior of a Binary Mixture of Ionic Liquids

Author: Agilio A. H. Padua, Margarida F. Costa Gomes, Luiz Fernando Lepre, Mauro C. C. Ribeiro, Rômulo A. Ando, Laboratoire de Chimie - UMR5182 (LC), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon)-Institut de Chimie du CNRS (INC), Institute of Chemistry [University of São Paulo] | Instituto de Química [Universidade de São Paulo], University of São Paulo (USP), Institute of Chemistry, University of São Paulo, École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Universidade de São Paulo = University of São Paulo (USP), and ANR-16-IDEX-0005,IDEXLYON,IDEXLYON(2016)
Subjects: Materials science, 010304 chemical physics, Logarithm, Enthalpy, Analytical chemistry, Regular solution, Infrared spectroscopy, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Surfaces, Coatings and Films, Ion, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, chemistry.chemical_compound, symbols.namesake, chemistry, 0103 physical sciences, Ionic liquid, Materials Chemistry, symbols, TERMODINÂMICA (FÍSICO-QUÍMICA), Physical and Theoretical Chemistry, Raman spectroscopy, Dicyanamide, ComputingMilieux_MISCELLANEOUS
Abstract: Binary mixtures of the ionic liquids 1-ethyl-3-methylimidazolium dicyanamide and tributyl(methyl)ammonium dicyanamide, [C2C1im]x[N4441](1-x)[N(CN)2], are studied by means of their excess properties (enthalpy and volume), their viscosity, and their Raman spectra. The mixtures exhibit positive values of excess volume VE and excess enthalpy HE. The plot of the logarithm of viscosity as a function of composition is consistent with the finding HE > 0. The excess thermodynamic properties of the ionic liquid mixtures are compared with well-known results for binary mixtures of (high-temperature) molten salts. The asymmetry of the curve HE versus composition is reproduced by considering the volumetric fraction of the [C2C1im]x[N4441](1-x)[N(CN)2] mixtures according to basic results of the theory of regular solutions. The anion totally symmetric stretching mode νs(C≡N) was used to probe the local environment around the anion in a Raman spectroscopy investigation of the [C2C1im]x[N4441](1-x)[N(CN)2] mixtures as a function of the composition. The Raman band shape (peak frequency and bandwidth) of the νs(C≡N) mode changes as expected from the fluctuation of concentration around the probe oscillator according to models for vibrational spectroscopy of liquid mixtures. This thermodynamic and spectroscopic study leads to the classification of the [C2C1im]x[N4441](1-x)[N(CN)2] mixture as a regular solution. The application of the regular solution equation for HE to other ionic liquid binary mixtures is discussed.
Published: 2019

20. Progressive circuit resistance training improves inflammatory biomarkers and insulin resistance in obese men

Author: Georges Jabbour, Amira Ben Moussa Zouita, Abderraouf Ben Abderrahmane, Maysa Vieira de Sousa, Amani Ayadi, Sarkawt Kolahdouzi, Farhad Ahmadi Kani-Golzar, Ayoub Saeidi, Mohammad Baghadam, Hassane Zouhal, University of Mazandaran, West Tehran Islamic Azad University [Tehran] (WTIAU), Qatar University, University of São Paulo (USP), Laboratoire Mouvement Sport Santé (M2S), École normale supérieure - Cachan (ENS Cachan)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of Mazandaran (UMZ), Universidade de São Paulo = University of São Paulo (USP), and Université de Rennes (UR)-École normale supérieure - Rennes (ENS Rennes)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Adult, Male, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Experimental and Cognitive Psychology, Body Mass Index, Exercise training, Young Adult, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Insulin resistance, Waist–hip ratio, Adipokine, Internal medicine, medicine, Humans, Chemerin, 0501 psychology and cognitive sciences, Obesity, 050102 behavioral science & comparative psychology, Cardiovascular fitness, ComputingMilieux_MISCELLANEOUS, Inflammation, 2. Zero hunger, Serum Amyloid A Protein, medicine.diagnostic_test, biology, business.industry, 05 social sciences, C-reactive protein, Resistance Training, medicine.disease, Lipids, 3. Good health, Apelin, C-Reactive Protein, Endocrinology, Body Composition, biology.protein, Chemokines, Insulin Resistance, Circuit-Based Exercise, Lipid profile, business, Body mass index, Biomarkers, 030217 neurology & neurosurgery
Abstract: Circuit resistance training (CRT) is a time-efficient exercise modality for improving skeletal muscle and cardiovascular fitness. But the beneficial role of CRT in obese individuals is still not well understood. This study explores the reducing effects of progressive CRT on inflammatory biomarkers and cardiometabolic risk factors in obese young men. Methods: Thirty obese men (Body mass index (BMI): 30.67 3.06; age: 23 3.2 years) were divided into CRT and control groups. The CRT was performed for eight-weeks (3 times/week, 65 85% of 1 repetition maximum). Fasting blood samples were taken pre and post intervention for analyzing apelin, chemerin, serum amyloid A (SAA), C reactive protein concentrations (CRP), lipid profile, and insulin resistance index. The data were assessed by two-way repeated measures ANOVA. Results: Body mass, BMI and waist to hip ratio (WHR) were significantly decreased after training intervention (P < .05). Compared to the control group, the plasma concentrations of Chemrin (P = .038), SAA (P = .004), insulin (P < .001), insulin resistance index (P < .001), total cholesterol (P = .033), triglyceride (P < .001), and low-density lipoprotein (P = .039), were significantly mitigated in the CRT group, but high-density lipoprotein plasma levels increased in the CRT group compared to that of the control group (P = .035). There was no significant difference between two groups in apelin and CRP (P > .05). Moreover, insulin resistance was positively correlated with apelin (r = 0.56) and chemerin (r = 0.51). Also, chemerin had a positive correlation with SAA (r = 0.49), and WHR (r = 0.54). Conclusion: CRT caused an improvement in inflammation and cardiometabolic risk factors in young obese men, and this improvement was accompanied by decreased insulin resistance. Scopus
Published: 2019

21. Carbon nanotube–ruthenium hybrid towards mild oxidation of sulfides to sulfones: efficient synthesis of diverse sulfonyl compounds

Author: Roberto da Silva Gomes, Valérie Geertsen, Eric Doris, Renato L. Carvalho, Carlos A. de Simone, Eufrânio N. da Silva Júnior, Elumalai Gopi, Mateus P Nunes, Edmond Gravel, Leandro F. Pedrosa, Renata G. Almeida, Institute of Exact Sciences, Universidade Federal de Minas Gerais [Belo Horizonte] (UFMG), Department of Chemistry and Chemical Biology [Harvard], Harvard University [Cambridge], Fluminense Federal University [Niterói], Sao Carlos Institute of Physics, University of Sao Paulo, University of São Paulo (USP), Service de Chimie Bio-Organique et de Marquage (SCBM), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire Interdisciplinaire sur l'Organisation Nanométrique et Supramoléculaire (LIONS), Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M) (NIMBE UMR 3685), Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Harvard University, Universidade de São Paulo = University of São Paulo (USP), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Rayonnement Matière de Saclay (IRAMIS), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: inorganic chemicals, Sulfonyl, chemistry.chemical_classification, 010405 organic chemistry, chemistry.chemical_element, Nanoparticle, Carbon nanotube, 010402 general chemistry, Heterogeneous catalysis, 7. Clean energy, 01 natural sciences, Combinatorial chemistry, Catalysis, 0104 chemical sciences, Ruthenium, law.invention, chemistry, law, [CHIM]Chemical Sciences
Abstract: International audience; A heterogeneous catalyst was assembled with ruthenium nanoparticles on carbon nanotubes and used in a mild oxidation method to prepare sulfones from sulfides. The system proved very efficient on the investigated substrates and the products were obtained in high yields.
Published: 2019

22. Nonlinear control for modular multilevel converters with enhanced stability region and arbitrary closed loop dynamics

Author: Luis F. N. Lourenco, Gilney Damm, Renato Machado Monaro, Françoise Lamnabhi-Lagarrigue, Miguel Jimenez Carrizosa, Guacira Costa de Oliveira, Laboratoire des signaux et systèmes (L2S), CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Universidade de São Paulo = University of São Paulo (USP), Informatique, BioInformatique, Systèmes Complexes (IBISC), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay, Universidad Politécnica de Madrid (UPM), and University of São Paulo (USP)
Subjects: Lyapunov function, Computer science, 020209 energy, 020208 electrical & electronic engineering, Automatic frequency control, Energy Engineering and Power Technology, PID controller, 02 engineering and technology, AC power, Nonlinear control, 7. Clean energy, symbols.namesake, [SPI]Engineering Sciences [physics], Control theory, Robustness (computer science), Backstepping, 0202 electrical engineering, electronic engineering, information engineering, symbols, Feedback linearization, Electrical and Electronic Engineering, ComputingMilieux_MISCELLANEOUS
Abstract: This paper presents the nonlinear control design with formal stability proof for a Modular Multilevel Converter (MMC), which is critical for the interaction between AC and DC grids. Lyapunov theory is used to develop the proposed controller, which is based on Backstepping and Feedback Linearization techniques and to perform the stability analysis. The proposed controller allows to asymptotically stabilize all converter’s states, i.e., AC currents, circulating currents, and internal energy. The proposed algorithm allows to manage the converter in a wide range of operation points, by means of arbitrary tuning assignment. Robustness and performances of proposed control are verified by means of Matlab Simscape Electrical simulations, including active and reactive power reference variations and grid imbalance conditions. A detailed MMC switching model, of 450 MVA is considered on Matlab validation. A phase-shift PWM is considered, with a sorting algorithm. Also, a comparison with a standard PI controller is performed. In addition, MMC’s internal energy is also controlled, which can contribute to the high-speed frequency control by using this energy for synthetic inertia.
Published: 2021

23. Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity

Author: Luciana Medina, Florencia González-Lizárraga, Antonio Dominguez-Meijide, Diego Ploper, Valeria Parrales, Sabrina Sequeira, Maria-Sol Cima-Omori, Markus Zweckstetter, Elaine Del Bel, Patrick P. Michel, Tiago Fleming Outeiro, Rita Raisman-Vozari, Rosana Chehín, Sergio B. Socias, Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), Universidade de Santiago de Compostela [Spain] (USC ), Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III [Madrid] (ISC), University of Göttingen - Georg-August-Universität Göttingen, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Max-Planck-Institut für Biophysikalische Chemie - Max Planck Institute for Biophysical Chemistry [Göttingen], Max-Planck-Gesellschaft, University of São Paulo (USP), Max Planck Institute of Experimental Medicine [Göttingen] (MPI), Newcastle University [Newcastle], Georg-August-University = Georg-August-Universität Göttingen, Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Universidade de São Paulo = University of São Paulo (USP), and Gestionnaire, Hal Sorbonne Université
Subjects: 0301 basic medicine, Drug, Aging, [SDV]Life Sciences [q-bio], Cognitive Neuroscience, media_common.quotation_subject, Tau protein, Neuronal toxicity, Pharmacology, Protein aggregation, protein aggregation, lcsh:RC321-571, 03 medical and health sciences, 0302 clinical medicine, mental disorders, medicine, ddc:610, tau, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Repurposing, Original Research, media_common, Doxycycline, biology, doxycycline, Chemistry, tauopathies, Alzheimer's disease, 3. Good health, [SDV] Life Sciences [q-bio], 030104 developmental biology, Toxicity, Amyloid aggregation, biology.protein, 030217 neurology & neurosurgery, Neuroscience, medicine.drug
Abstract: International audience; Tauopathies are neurodegenerative disorders with increasing incidence and still without cure. The extensive time required for development and approval of novel therapeutics highlights the need for testing and repurposing known safe molecules. Since doxycycline impacts α-synuclein aggregation and toxicity, herein we tested its effect on tau. We found that doxycycline reduces amyloid aggregation of the 2N4R and K18 isoforms of tau protein in a dose-dependent manner. Furthermore, in a cell free system doxycycline also prevents tau seeding and in cell culture reduces toxicity of tau aggregates. Overall, our results expand the spectrum of action of doxycycline against aggregation-prone proteins, opening novel perspectives for its repurposing as a disease-modifying drug for tauopathies.
Published: 2021

24. A hotspot of Toxoplasma gondii Africa 1 lineage in Benin: How new genotypes from West Africa contribute to understand the parasite genetic diversity worldwide

Author: Anatole Laleye, Karine Berthier, Aurélien Mercier, Jonas Etougbétché, Lokman Galal, Gualbert Houemenou, Nadine Fievet, Richard Amagbégnon, Honoré Da Zoclanclounon, Gauthier Dobigny, Hilda Fátima de Jesus Pena, Azra Hamidović, Marie-Laure Dardé, Sylvain Piry, Aretas Babatoundé Nounnagnon Tonouhewa, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Ecole Polytechnique d'Abomey Calavi (EPAC), University of Abomey Calavi (UAC), Université d’Abomey-Calavi (UAC), Centre de Biologie pour la Gestion des Populations (UMR CBGP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Universitaire de la Mère et de l'Enfant Lagune (CHU-MEL), Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD)-Université de Paris (UP), Centre d’Etude et de Recherche sur le Paludisme Associé à la Grossesse et l’Enfance (CERPAGE), University of São Paulo (USP), Centre National de Référence (CNR) Toxoplasmose/Toxoplasma Biological Resource Center (BRC) (CNR Toxoplasmose-Toxoplasma BRC), CHU Limoges, This work was supported by funds from the French Agence Nationale de la Recherche (ANR project IntroTox ANR-17-CE35-0004 given to AM, funder for LG salary), the region of Nouvelle Aquitaine (funder for AH salary)., ANR-17-CE35-0004,IntroTox,PHENOMÈNES D'INTROGRESSIONS DANS L'ÉTUDE DE LA DIVERSITÉ GÉNÉTIQUE DU TOXOPLASME ENTRE LA FRANCE ET L'AFRIQUE DE L'OUEST ET CENTRALE : DES INFLUENCES HUMAINES ET ENVIRONEMENTALES(2017), Université d’Abomey-Calavi = University of Abomey Calavi (UAC), Laboratoire de Recherche en Biologie Appliquée (LaRBA), Ecole Polytechnique d’Abomey, Calavi (EPAC), Université d’Abomey, Calavi (UAC), Cotonou, Bénin, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Centre d’Etude et de Recherche sur le Paludisme Associé à la Grossesse et l’Enfance [Cotonou, Bénin] (CERPAGE), Universidade de São Paulo = University of São Paulo (USP), Berthier, Karine, PHENOMÈNES D'INTROGRESSIONS DANS L'ÉTUDE DE LA DIVERSITÉ GÉNÉTIQUE DU TOXOPLASME ENTRE LA FRANCE ET L'AFRIQUE DE L'OUEST ET CENTRALE : DES INFLUENCES HUMAINES ET ENVIRONEMENTALES - - IntroTox2017 - ANR-17-CE35-0004 - AAPG2017 - VALID, Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 261)
Subjects: 0301 basic medicine, [SDV]Life Sciences [q-bio], RC955-962, Toxoplasma Gondii, Geographical Locations, Mice, Arctic medicine. Tropical medicine, Genotype, Benin, Phylogeny, Protozoans, 2. Zero hunger, Geography, biology, Commerce, Eukaryota, Senegal, 3. Good health, Europe, [SDV] Life Sciences [q-bio], Phylogeography, Africa, Western, Infectious Diseases, Biogeography, Public aspects of medicine, RA1-1270, Toxoplasma, Brazil, Polymorphism, Restriction Fragment Length, Research Article, Lineage (genetic), 030106 microbiology, Triangular trade, Zoology, 03 medical and health sciences, parasitic diseases, Genetics, medicine, Animals, Humans, Gabon, Genotyping, Poultry Diseases, Evolutionary Biology, Genetic diversity, Population Biology, Ecology and Environmental Sciences, Organisms, Public Health, Environmental and Occupational Health, Biology and Life Sciences, Genetic Variation, Toxoplasma gondii, South America, biology.organism_classification, medicine.disease, Parasitic Protozoans, Toxoplasmosis, Genetics, Population, Toxoplasmosis, Animal, 030104 developmental biology, People and Places, Africa, Earth Sciences, Chickens, Population Genetics, Microsatellite Repeats
Abstract: Through international trades, Europe, Africa and South America share a long history of exchanges, potentially of pathogens. We used the worldwide parasite Toxoplasma gondii to test the hypothesis of a historical influence on pathogen genetic diversity in Benin, a West African country with a longstanding sea trade history. In Africa, T. gondii spatial structure is still non-uniformly studied and very few articles have reported strain genetic diversity in fauna and clinical forms of human toxoplasmosis so far, even in African diaspora. Sera from 758 domestic animals (mainly poultry) in two coastal areas (Cotonou and Ouidah) and two inland areas (Parakou and Natitingou) were tested for T. gondii antibodies using a Modified Agglutination Test (MAT). The hearts and brains of 69 seropositive animals were collected for parasite isolation in a mouse bioassay. Forty-five strains were obtained and 39 genotypes could be described via 15-microsatellite genotyping, with a predominance of the autochthonous African lineage Africa 1 (36/39). The remaining genotypes were Africa 4 variant TUB2 (1/39) and two identical isolates (clone) of Type III (2/39). No difference in terms of genotype distribution between inland and coastal sampling sites was found. In particular, contrarily to what has been described in Senegal, no type II (mostly present in Europe) was isolated in poultry from coastal cities. This result seems to refute a possible role of European maritime trade in Benin despite it was one of the most important hubs during the slave trade period. However, the presence of the Africa 1 genotype in Brazil, predominant in Benin, and genetic analyses suggest that the triangular trade was a route for the intercontinental dissemination of genetic strains from Africa to South America. This supports the possibility of contamination in humans and animals with potentially imported virulent strains., Author summary The parasite Toxoplasma gondii is a worldwide-distributed pathogen, able to infect all warm-blooded animals. There are important differences in the clinical expression of the infection in direct relation with the parasite genetic profile. In some regions, the geographical structuration of its genetic diversity points towards a crucial role of human activities in some lineages introduction or sorting. Benin is a West African country with a history of extensive transcontinental exchanges. Our genetic study of Toxoplasma in Benin shows a surprisingly homogeneous and autochthonous diversity, which contrasts with previous studies from other West and Central African countries. In Benin, the absence of European Toxoplasma lineages may be explained by the extreme rarity of the house mouse (Mus musculus), a host species that was previously described as highly susceptible to the mouse-virulent African strains. Might Benin be the origin region for the Africa 1 lineage, our results suggest that Guinean Gulf coasts may be a starting point of this lineage towards South America, especially Brazil, during the slave trade. As a whole, the present study provides further insights into the recent evolutionary history of Toxoplasma gondii and its consequences on human and animal health.
Published: 2021

25. Tumor Microenvironment Autophagic Processes and Cachexia: The Missing Link?

Author: Renata de Castro Gonçalves, Paula Paccielli Freire, Dario Coletti, Marilia Seelaender, Universidade de São Paulo = University of São Paulo (USP), Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing (B2A), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), HAL-SU, Gestionnaire, University of São Paulo (USP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome]
Subjects: Cancer Research, autophagy, systemic inflammations, medicine.medical_treatment, Inflammation, [SDV.CAN]Life Sciences [q-bio]/Cancer, Review, Systemic inflammation, lcsh:RC254-282, cachexia, Cachexia, 03 medical and health sciences, 0302 clinical medicine, Immune system, [SDV.CAN] Life Sciences [q-bio]/Cancer, medicine, tumor microenvironment, 030304 developmental biology, 0303 health sciences, Tumor microenvironment, DAMPs, business.industry, Autophagy, lymphocyte infiltration, metabolism, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 3. Good health, Cytokine, Oncology, Tumor progression, 030220 oncology & carcinogenesis, Cancer research, medicine.symptom, business
Abstract: International audience; Cachexia is a syndrome that affects the entire organism and presents a variable plethora of symptoms in patients, always associated with continuous and involuntary degradation of skeletal muscle mass and function loss. In cancer, this syndrome occurs in 50% of all patients, while prevalence increases to 80% as the disease worsens, reducing quality of life, treatment tolerance, therapeutic response, and survival. Both chronic systemic inflammation and immunosuppression, paradoxically, correspond to important features in cachexia patients. Systemic inflammation in cachexia is fueled by the interaction between tumor and peripheral tissues with significant involvement of infiltrating immune cells, both in the peripheral tissues and in the tumor itself. Autophagy, as a process of regulating cellular metabolism and homeostasis, can interfere with the metabolic profile in the tumor microenvironment. Under a scenario of balanced autophagy in the tumor microenvironment, the infiltrating immune cells control cytokine production and secretion. On the other hand, when autophagy is unbalanced or dysfunctional within the tumor microenvironment, there is an impairment in the regulation of immune cell’s inflammatory phenotype. The inflammatory phenotype upregulates metabolic consumption and cytokine production, not only in the tumor microenvironment but also in other tissues and organs of the host. We propose that cachexia-related chronic inflammation can be, at least, partly associated with the failure of autophagic processes in tumor cells. Autophagy endangers tumor cell viability by producing immunogenic tumor antigens, thus eliciting the immune response necessary to counteract tumor progression, while preventing the establishment of inflammation, a hallmark of cachexia. Comprehensive understanding of this complex functional dichotomy may enhance cancer treatment response and prevent/mitigate cancer cachexia. This review summarizes the recent available literature regarding the role of autophagy within the tumor microenvironment and the consequences eliciting the development of cancer cachexia.
Published: 2021

26. Contributive Role of TNF-α to L-DOPA-Induced Dyskinesia in a Unilateral 6-OHDA Lesion Model of Parkinson’s Disease

Author: Maurício dos Santos Pereira, Gabriel Henrique Dias Abreu, Jeremy Rocca, Sabah Hamadat, Rita Raisman-Vozari, Patrick Pierre Michel, Elaine Del Bel, University of São Paulo (USP), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Universidade de São Paulo = University of São Paulo (USP), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Gestionnaire, Hal Sorbonne Université, and Michel, Patrick Pierre
Subjects: 0301 basic medicine, [SDV]Life Sciences [q-bio], microglia, glutamate, Striatum, Pharmacology, neuroinflammation, 03 medical and health sciences, chemistry.chemical_compound, cannabidiol, 0302 clinical medicine, astrocyte, Dopamine, neuroinflammation, TNF-α, medicine, Pharmacology (medical), Neuroinflammation, Original Research, Microglia, lcsh:RM1-950, Glutamate receptor, 3. Good health, [SDV] Life Sciences [q-bio], 030104 developmental biology, medicine.anatomical_structure, lcsh:Therapeutics. Pharmacology, chemistry, IL-1β, TNF-α, dopamine, Capsazepine, Cannabidiol, 030217 neurology & neurosurgery, Astrocyte, medicine.drug
Abstract: International audience; Our present objective was to better characterize the mechanisms that regulate striatal neuroinflammation in mice developing L-DOPA-induced dyskinesia (LID). For that, we used 6-hydroxydopamine (6-OHDA)-lesioned mice rendered dyskinetic by repeated intraperitoneal injections of 3,4-dihydroxyphenyl-L-alanine (L-DOPA) and quantified ensuing neuroinflammatory changes in the dopamine-denervated dorsal striatum. LID development was associated with a prominent astrocytic response, and a more moderate microglial cell reaction restricted to this striatal area. The glial response was associated with elevations in two pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin-1β. Treatment with the phytocannabinoid cannabidiol and the transient receptor potential vanilloid-1 (TRPV-1) channel antagonist capsazepine diminished LID intensity and decreased TNF-α levels without impacting other inflammation markers. To possibly reproduce the neuroinflammatory component of LID, we exposed astrocyte and microglial cells in culture to candidate molecules that might operate as inflammatory cues during LID development, i.e., L-DOPA, dopamine, or glutamate. Neither L-DOPA nor dopamine produced an inflammatory response in glial cell cultures. However, glutamate enhanced TNF-α secretion and GFAP expression in astrocyte cultures and promoted Iba-1 expression in microglial cultures. Of interest, the antidyskinetic treatment with cannabidiol + capsazepine reduced TNF-α release in glutamate-activated astrocytes. TNF-α, on its own, promoted the synaptic release of glutamate in cortical neuronal cultures, whereas cannabidiol + capsazepine prevented this effect. Therefore, we may assume that the release of TNF-α by glutamate-activated astrocytes may contribute to LID by exacerbating corticostriatal glutamatergic inputs excitability and maintaining astrocytes in an activated state through a self-reinforcing mechanism.
Published: 2021

27. Empirical formulation for multiple groups of primary biological ice nucleating particles from field observations over Amazonia

Author: Vaughan T. J. Phillips, Cindy E. Morris, Paul J. DeMott, Susannah M. Burrows, Sachin Patade, Bettina Weber, Fábio Luiz Teixeira Gonçalves, Christopher Pöhlker, Pierre Amato, Jann Schrod, Heinz Bingemer, Carl Alwmark, Daniel A. Knopf, Paulo Artaxo, Department of Physical Geography and Ecosystem Science [Lund], Lund University [Lund], Institut de Chimie de Clermont-Ferrand (ICCF), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Institute for Atmospheric and Environmental Sciences [Frankfurt/Main] (IAU), Goethe-University Frankfurt am Main, Atmospheric Sciences and Global Change Division, Pacific Northwest National Laboratory (PNNL), Department of Atmospheric Science [Fort Collins], Colorado State University [Fort Collins] (CSU), Departamento de Ciencias Atmosfericas [São Paulo], Instituto de Astronomia, Geofísica e Ciências Atmosféricas [São Paulo] (IAG), Universidade de São Paulo = University of São Paulo (USP)-Universidade de São Paulo = University of São Paulo (USP), Institute for Terrestrial and Planetary Atmospheres [Stony Brook] (ITPA), School of Marine and Atmospheric Sciences [Stony Brook] (SoMAS), Stony Brook University [SUNY] (SBU), State University of New York (SUNY)-State University of New York (SUNY)-Stony Brook University [SUNY] (SBU), State University of New York (SUNY)-State University of New York (SUNY), Unité de Pathologie Végétale (PV), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Geology [Lund], Universidade de São Paulo = University of São Paulo (USP), Multiphase Chemistry Department [Mainz], Max Planck Institute for Chemistry (MPIC), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Karl-Franzens-Universität Graz, Swedish Research Council (‘Vetenskapsradet’), German Federal Ministry of Education and Research (BMBF contracts 01LB1001A, 01LK1602A and 01LK1602B), U.S. National Science Foundation Award #1660486, NASA award NNX17AJ12G, Deutsche Forschungsgemeinschaft (DFG) under the Research Unit FOR 1525 (INUIT), Max Planck Society, Brazilian Ministério da Ciência, Tecnologia e Inovação (MCTI/FINEP contract 01.11.01248.00), Amazon State University (UEA), FAPEAM, LBA/INPA, SDS/CEUC/RDS-Uatumã, U.S. Department of Energy, Office of Science (BER), Atmospheric System Research (DE-SC0018929, DE-SC0016370, DE-SC0020006), European Project: 603445,EC:FP7:ENV,FP7-ENV-2013-two-stage,BACCHUS(2013), Universidade de São Paulo (USP)-Universidade de São Paulo (USP), Universidade de São Paulo (USP), Karl-Franzens-Universität [Graz, Autriche], and University of Graz
Subjects: [PHYS.PHYS.PHYS-AO-PH]Physics [physics]/Physics [physics]/Atmospheric and Oceanic Physics [physics.ao-ph], Atmospheric Science, Detritus, 010504 meteorology & atmospheric sciences, Atmospheric models, biology, Amazon rainforest, medicine.disease_cause, Atmospheric sciences, biology.organism_classification, 01 natural sciences, Soot, 010305 fluids & plasmas, Aerosol, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Algae, FLORESTAS TROPICAIS, Pollen, 0103 physical sciences, medicine, Ice nucleus, Environmental science, [MATH]Mathematics [math], 0105 earth and related environmental sciences, Amazonie
Abstract: To resolve the various types of biological ice nuclei (IN) with atmospheric models, an extension of the empirical parameterization (EP) (Phillips et al. 2008; 2013) is proposed to predict the active IN from multiple groups of primary biological aerosol particles (PBAPs). Our approach is to utilize coincident observations of PBAP sizes, concentrations, biological composition, and ice-nucleating ability. The parameterization organizes the PBAPs into five basic groups: fungal spores, bacteria, pollen, viral particles, plant/animal detritus, algae, and their respective fragments. This new biological component of the EP was constructed by fitting predicted concentrations of PBAP IN to those observed at the Amazon Tall Tower Observatory (ATTO) site located in the central Amazon. The fitting parameters for pollen and viral particles, plant/animal detritus, which are much less active as IN than fungal and bacterial groups, are constrained based on their ice nucleation activity from the literature. The parameterization has empirically derived dependencies on the surface area of each group (except algae), and the effects of variability in their mean sizes and number concentrations are represented via their influences on the surface area. The concentration of active algal IN is estimated from literature-based measurements.Predictions of this new biological component of the EP are consistent with previous laboratory and field observations not used in its construction. The EP scheme was implemented in a 0D parcel model. It confirms that biological IN account for most of the total IN activation at temperatures warmer than −20°C and at colder temperatures dust and soot become increasingly more important to ice nucleation.
Published: 2021

28. Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID-19 pandemic

Author: Ajit S. Puri, Allan Taylor, Huynh Le Vu, Tatemi Todaka, Teddy Y. Wu, Octavio M. Pontes-Neto, Eytan Raz, Pedro Lylyk, Jasmine Johann, Roberta Novakovic, Hormuzdiyar H. Dasenbrock, Francisco Mont’Alverne, Nobuyuki Sakai, Melanie Walker, Hugh Stephen Winters, Ossama Mansour, Yohei Takenobu, Gregory Walker, Miki Fujimura, Saif Bushnaq, Odysseas Kargiotis, Nabeel Herial, Markus A Möhlenbruch, Malveeka Sharma, Hiroshi Tokimura, Maxim Mokin, Jean Raymond, Michael D. Hill, Amal Abou-Hamden, Leonardo Renieri, Serdar Geyik, Yuri Sugiura, Luisa Fonseca, Roberto Crosa, Fabricio O Lima, Ameer E Hassan, Viet Quy Nguyen, Jane G. Morris, Steven W. Hetts, Jawad F. Kirmani, Matthew S. Tenser, Muhammad M. Qureshi, Gianmarco Bernava, Mahmoud H Mohammaden, Verónica V. Olavarría, Jun Deguchi, André Beer-Furlan, Steve M. Cordina, Hiroshi Yamagami, Mohamad Abdalkader, Toshiyuki Fujinaka, Clifford J. Eskey, Rotem Sivan-Hoffmann, Hao Zhang, Anirudh Kulkarni, Brendan Steinfort, Özlem Aykaç, Barbara Voetsch, Alex Brehm, Italo Linfante, Wenguo Huang, Omer Eker, M. Luis Silva, Pascal Jabbour, Lissa Peeling, Mollie McDermott, Pascale Lavoie, Kazutaka Sonoda, Thomas Devlin, Alicia C. Castonguay, Jin Soo Lee, Diogo C Haussen, Dileep R. Yavagal, Thanh N. Nguyen, Umair Rashid, Vasu Saini, Raghid Kikano, Hiroyuki Hashimoto, Masaaki Uno, Saima Ahmad, Artem Kaliaev, Eiji Hagashi, Ajay K. Wakhloo, Romain Bourcier, Ryoo Yamamoto, Jesse M. Thon, Georgios Tsivgoulis, Dorothea Altschul, Achmad Fidaus Sani, Satoshi Yamada, Varsha Singh, David S Liebeskind, Tatsuo Amano, Anchalee Churojana, Juan F. Arenillas, Junichi Iida, Charles C. Matouk, Nobuyuki Ohara, Osama O. Zaidat, Mario Martínez-Galdámez, Chandril Chugh, Don Frei, Vanessa Chalumeau, Brijesh P Mehta, Marios Psychogios, Anna Luisa Kühn, Leticia C Rebello, Xianjin Shang, Hosam Al-Jehani, Hiroki Fukuda, Hong Gee Roh, Gisele Sampaio Silva, Rakesh Khatri, Kenichi Todo, Amal Al Hashmi, Alex Bou Chebl, Sunil A Sheth, Zhongming Qiu, Oriana Cornett, Zhengzhou Yuan, Wazim Izzath, Hesham Masoud, Rodrigo Rivera, Michel Piotin, Vikram Huded, Mamoru Murakami, Mohamed Teleb, Viktor Szeder, Ruchir Shah, Dheeraj Gandhi, John Thornton, Michael Chen, Vitor Mendes Pereira, Nadia Hammami, Alice Ma, Anna M. Cervantes-Arslanian, James E. Siegler, Seby John, Carlos Ynigo Lopez, Mudassir Farooqui, David Ozretić, Takuya Kanamaru, Romain Guile, Daisuke Watanabe, Kosuke Miyake, Alejandro Rodriguez Vasquez, Patrick Nicholson, Yuki Yamamoto, William J. Mack, Naoto Kimura, Simon Mathew John, Robert Fahed, Yuji Matsumaru, David Y. Chung, Rishi Gupta, Ryuhei Kono, Michael Frankel, Victor S. Lopez Rivera, Johanna T. Fifi, Raul G Nogueira, Paolo Machi, Tudor G. Jovin, Jordi Blasco, Emma Griffin, Salvatore Mangiafico, Masafumi Morimoto, Jun Luo, Santiago Ortega-Gutierrez, Monika Killer-Oberpfalzer, Daniel Giansante Abud, Syed I. Hussain, Fawaz Al-Mufti, Yusuke Sugimura, Atilla Özcan Özdemir, Stephan A. Mayer, Sumeet Multani, Adel Alhazzani, Alhamza R Al-Bayati, Michael Kelly, Lee A Birnbaum, Shadi Yaghi, Jeyaraj D Pandian, Ji Man Hong, Junsuke Shimbo, Johnny Ho-Yin Wong, Elena A. Cora, Laura Mechtouff, Pedro S.C. Magalhães, Pablo M. Lavados, Yuichi Murayama, Dong Hun Shin, Simon Nagel, Ken Wong, Jose Antonio Fiorot, Jeremy Payne, Randall C. Edgell, Adrienne Weeks, CarMeN, laboratoire, Department of Neurology [Boston], Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston], Emory University School of Medicine, Emory University [Atlanta, GA], Boston University School of Medicine (BUSM), Boston University [Boston] (BU), National Hospital Organization Osaka National Hospital [Japon] (NHO Osaka National Hospital), Alexandria University [Alexandrie], Boston Medical Center [Boston, MA, USA] (BMC), Xinqiao Hospital [Chongqing, China] (XH), University of Cape Town, La Sagrada Familia Clinic/Clínica La Sagrada Familia [Buenos Aires, Argentina] (LSFC), Hospices Civils de Lyon (HCL), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Fondation Ophtalmologique Adolphe de Rothschild [Paris], Hospital General de Fortaleza [Fortaleza, Brazil] (HGF), Nottingham University Hospitals NHS Trust [UK], Kobe City Medical Center General Hospital [Kobe, Hyogo, Japan] (KCMCGH), Azienda Ospedaliero-Universitaria Careggi [Firenze, Toscana, Italy] (AOUC), University Hospital Centre Zagreb, Partenaires INRAE, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Service de Neuroradiologie [CHU de Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Cleveland Clinic Abu Dhabi [Abou Dabi, Émirats arabes unis], Hôpital de Beaumont [Dublin, Ireland] (HB), Hospital-Estadual Central [Vitoria, Brazil] (HEC), Instituto de NeuroCirugía Asenjo, Institut national de neurologie Mongi-Ben Hamida [Tunis], Hue Central Hospital [Thua Thien Hue, Vietnam] (HCH), University of California [San Francisco] (UC San Francisco), University of California (UC), Centre hospitalier universitaire de Nantes (CHU Nantes), Washington University School of Medicine (WUSM), University of Washington [Seattle], Englewood Hospital and Medical Center [Englewood], Jefferson (Philadelphia University + Thomas Jefferson University), Westchester Medical Center [Valhalla, New York, USA] (WMC), Eskisehir Osmangazi University, University of Maryland School of Medicine, University of Maryland System, MAX Superspecialty Hospital [Saket, New Delhi, India] (MSH), Yale School of Medicine [New Haven, Connecticut] (YSM), Université Laval [Québec] (ULaval), Washington University School of Medicine in St. Louis, Washington University in Saint Louis (WUSTL), Rush University Medical Center [Chicago], Paracelsus Medizinische Privatuniversität = Paracelsus Medical University (PMU), University of Toronto, NH Mazumdar Shah Medical Center [Bangalore, India] (NHMSMC), IMS Tokyo-Katsushika General Hospital [Tokyo, Japan], Gachon University [Seongnam, Korea] (GU), Hospital Municipal Sao Jose [Joinville, Santa Catarina, Brazil] (HMSJ), Lau Medical Center [Beirut, Lebanon] (LMC), University of Iowa [Iowa City], Royal Adelaide Hospital [Adelaide Australia], Kyorin University [Tokyo, Japan], Yokohama Brain and Spine Center [Yokohama, Japan] (YBSC), Dalhousie University [Halifax], Rambam Health Care Campus [Haifa, Israel], Centro Endovascular Neurologico Medica Uruguaya [Montevideo, Uruguay] (CENMU), Heidelberg University Hospital [Heidelberg], Imam Abdulrahman bin Faisal University [Alkhobar, Saudi Arabia] (IAFU), McGovern Medical School [Houston, TX, USA] (McGMS), The University of Texas Health Science Center at Houston (UTHealth), Cooper Medical School of Rowan University [Camden] (CMSRU), Airlangga University [Jawa Timur, Indonesia] (AU), University of Massachusetts Medical School [Worcester] (UMASS), University of Massachusetts System (UMASS), Geneva University Hospitals and Geneva University, Universidade de São Paulo = University of São Paulo (USP), Beth Israel Lahey Health [Burlington, MA, USA] (BILH), New York University School of Medicine (NYU Grossman School of Medicine), Memorial Neuroscience Institute [Pembroke Pines, FL, USA] (MNI), Iwate Prefectural Central Hospital [Morioka, Iwate, Japan] (IPCH), Japanese Red Cross Musashino Hospital [Tokyo], Ajou University, University of Ottawa [Ottawa], Saga-ken Medical Centre Koseikan [Saga, Japan] (SMCK), University of South Alabama, Konkuk University [Seoul], Royal Free Hospital [London, UK], Hospital Clinico Universitario de Valladolid [Castilla y León, Spain] (HCUV), Universidad de Valladolid [Valladolid] (UVa), Instituto de Ciencia de Materiales de Aragón [Saragoza, España] (ICMA-CSIC), University of Zaragoza - Universidad de Zaragoza [Zaragoza], Hospital Clínic de Barcelona [Catalonia, Spain], Centro Hospitalar Universitário de São João [Porto], Christchurch Hospital [Christchurch, New Zealand] (CH), University Hospital Basel [Basel], University of Southern California (USC), Kohnan Hospital - Sendai [Miyagi, Japan], University of Texas Southwestern Medical Center [Dallas], Nara City Hospital [Nara, Japan] (NCH), Toyonaka Municipal Hospital [Osaka, Japan] (TMH), Kagoshima City Hospita [Kagoshima, Japan] (KCH), Texas Tech University System [Lubbock, TX, USA] (TTUS), University of Saskatchewan [Saskatoon] (U of S), National Institute of Information and Communications Technology [Tokyo, Japan] (NICT), Royal Prince Alfred Hospital [Camperdown, Australia] (RPAH), Banner Desert Medical Center [Mesa, AZ, USA] (BDMC), Japanese Red Cross Matsue Hospital [Shimane, Japan] (JRCMH), Shiroyama Hospital [Osaka, Japan] (SH), Niigata City General Hospital [Niigata, Japan] (NCGH), Sugimura Hospital [Kumamoto, Japan] (SH), Kawasaki Medical School [Kurashiki, Japan] (KMS), Osaka Red Cross Hospital [Osaka, Japan] (ORCH), Université de Tsukuba = University of Tsukuba, Saiseikai Central Hospital [Tokyo, Japan] (SCH), Kinikyo Chuo Hospital - Sapporo [Hokkaido, Japan] (KCHS), NTT Medical Center Tokyo [Tokyo, Japan] (NTTMCT), Yokohama Shintoshi Neurosurgical Hospital [Yokohama, Japan]. (YSNH), Osaka General Medical Center [Osaka, Japan] (OGMC), University of Miami Leonard M. Miller School of Medicine (UMMSM), Bon Secours Mercy Health System [Toledo, OH, USA] (BSMHS), Maoming City Hospital [Guandong, China] (MCH), Miami Cardiac & Vascular Institute [Miami, FL, USA] (MC&VI), Hackensack University Medical Center [Hackensack], David Geffen School of Medicine [Los Angeles], University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC), University of Tennessee [Chattanooga] (UTC), The University of Texas at San Antonio (UTSA), Mianyang 404 Hospital [Sichuan, China] (M404H), Siriraj Hosital - Mahidol University [Bangkok, Thailand] (SHMU), SUNY Upstate Medical University, State University of New York (SUNY), Royal North Shore Hospital (RNSH), The University of Texas Rio Grande Valley [Harlingen, TX, USA] (UTRGV), Khoula Hospital [Muscat, Oman] (Ministry of Health - KH), University of Michigan [Ann Arbor], University of Michigan System, University of South Florida [Tampa] (USF), Henry Ford Health System [Detroit, MI, USA] (HFHS), Metropolitan Hospital [Piraeus, Greece] (MH), National and Kapodistrian University of Athens (NKUA), Maine Medical Center, Dartmouth Hitchcock Medical Center [Lebanon, NH, USA] (DHMC), Centro Universitário Feevale (BRAZIL), The Valley Hospital [Ridgewood, NJ, USA] (TVH), St Joseph's University Medical Center [Paterson, NJ, USA] (StJUMC), Christian Medical College and Hospital Ludhiana [Punjab, India] (CMCHL), Universidad del Desarrollo, University Graduate School of Medicine [Osaka, Japan], Tokushima University, Universidade Federal de São Paulo, Istanbul Aydin University [İstanbul, Turkey] (IAU), Swedish Medical Center [Englewood, CO, USA] (SMC), Bayhealth Medical Center [Dover, DE, USA] (BMC), Saiseikai Fukuoka General Hospital [Fukuoka, Japan] (SFGH), Osaka Rosai Hospital - Sakai [Osaka, Japan] (ORHS), King Saud University [Riyadh] (KSU), Mount Sinai Health System, University of Calgary, Huzhou University [Zhejiang], The Affiliated Hospital of Southwest Medical University - Luzhou [Sichuan, China] (TAHSMUL), Yijishan Hospital of Wannan Medical College [Wuhu, Anhui, China] (YHWMC), University of Toledo, WellStar Health System [Marietta, GA, USA] (WHS), Institut National de la Recherche Scientifique [Québec] (INRS), Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CR CHUM), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM)-Université de Montréal (UdeM), SVIN COVID-19 Registry, the Middle East North Africa Stroke and Interventional Neurotherapies Organization (MENA-SINO), Japanese Society of Vascular and Interventional Neurology Society (JVIN), University of California [San Francisco] (UCSF), University of California, Yale University School of Medicine, University of São Paulo (USP), and University of California-University of California
Subjects: [SDV]Life Sciences [q-bio], COVID-19, Subarachnoid Hemorrhage* / diagnostic imaging, 030204 cardiovascular system & hematology, Intracranial Aneurysm* / therapy, lcsh:RC346-429, 0302 clinical medicine, Pandemic, Myocardial infarction, Prospective Studies, Stroke, Original Research, 3. Good health, [SDV] Life Sciences [q-bio], Treatment Outcome, Intracranial Aneurysm* / diagnostic imaging, Cardiology, Subarachnoid haemorrhage, haemorrhage, Cardiology and Cardiovascular Medicine, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Subgroup analysis, subarachnoid, Intracranial Aneurysm* / epidemiology, 03 medical and health sciences, Aneurysm, Internal medicine, medicine, Humans, coil, cardiovascular diseases, Pandemics, lcsh:Neurology. Diseases of the nervous system, Retrospective Studies, business.industry, SARS-CoV-2, Intracranial Aneurysm, Subarachnoid Hemorrhage, medicine.disease, infection, nervous system diseases, Mechanical thrombectomy, Cross-Sectional Studies, aneurysm, Neurology (clinical), Subarachnoid Hemorrhage* / epidemiology, business, 030217 neurology & neurosurgery
Abstract: BackgroundDuring the COVID-19 pandemic, decreased volumes of stroke admissions and mechanical thrombectomy were reported. The study’s objective was to examine whether subarachnoid haemorrhage (SAH) hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines.MethodsWe conducted a cross-sectional, retrospective, observational study across 6 continents, 37 countries and 140 comprehensive stroke centres. Patients with the diagnosis of SAH, aneurysmal SAH, ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases, 10th Revision, codes. The 3-month cumulative volume, monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before (1 year and immediately before) and during the pandemic, defined as 1 March–31 May 2020. The prior 1-year control period (1 March–31 May 2019) was obtained to account for seasonal variation.FindingsThere was a significant decline in SAH hospitalisations, with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic, representing a relative decline of 22.5% (95% CI −24.3% to −20.7%, pInterpretationThere was a relative decrease in the volume of SAH hospitalisations, aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 pandemic. These findings in SAH are consistent with a decrease in other emergencies, such as stroke and myocardial infarction.
Published: 2021

29. Three-dimensional high spatial localization of efficient resonant energy transfer from laser-assisted precipitated silver clusters to trivalent Europium ions

Author: Gustavo Galleani, Yannick Petit, Véronique Jubera, Andrea S. S. de Camargo, Jean-Charles Desmoulin, Guillaume Raffy, André Del Guerzo, Lionel Canioni, Thierry Cardinal, Institut de Chimie de la Matière Condensée de Bordeaux (ICMCB), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Lasers Intenses et Applications (CELIA), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Bordeaux (UB), University of São Paulo (USP), Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), G.R. and A.D.G. thank the University of Bordeaux, the Centre National de Recherche Scientifique (CNRS) and Région Nouvelle Aquitaine for financial support. A.S.S.d.C. and G.G. would like to acknowledge Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) for the CEPID research grant (2013/07793-6). G.G. is specially thankful to FAPESP for the postdoctoral fellowship (2018/03931-9)., ANR-19-CE08-0021,ArchiFLUO,Architectures photoniques intégrées inscrites par laser femtoseconde pour étalonnage en microscopie de fluorescence dans l'infrarouge(2019), Université de Bordeaux (UB)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Universidade de São Paulo = University of São Paulo (USP), and Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1 (UB)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: FLIM spectroscopy, Resonant inductive coupling, Materials science, General Chemical Engineering, silver clusters, Analytical chemistry, chemistry.chemical_element, Physics::Optics, 02 engineering and technology, FRET process, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, CIE chomaticity diagram, 7. Clean energy, 01 natural sciences, law.invention, Ion, 010309 optics, Inorganic Chemistry, law, 0103 physical sciences, lcsh:QD901-999, General Materials Science, PROPRIEDADES DOS MATERIAIS, Chromaticity, Dexter process, Precipitation (chemistry), femtosecond laser inscription, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Laser, Fluorescence, resonant transfers, chemistry, 13. Climate action, Excited state, rare earth ions, CIE chromaticity diagram, lcsh:Crystallography, 0210 nano-technology, Europium
Abstract: We report on the 3D precipitation, using a direct laser writing approach, of highly fluorescent silver clusters in a Eu3+-doped silver-containing zinc phosphate glass. Micro-spectroscopy of fluorescence emission shows the ability to continuously adjust the local tri-chromatic coordinates in the CIE (Commission Internationale de l’Éclairage) chromaticity diagram between red and white colors, thanks to the laser-deposited dose and resulting tunable combination of emissions from Eu3+ and silver clusters. Moreover, continuous-wave and time-resolved FAST-FLIM spectroscopies showed a significant enhancement of the fluorescence emission of Eu3+ ions while being co-located with UV-excited laser-inscribed silver clusters. These results demonstrate the ability to perform efficient resonant non-radiative energy transfer from excited silver clusters to Eu3+, allowing such energy transfer to be highly localized on demand thanks to laser inscription. Such results open the route to 3D printing of the rare earth ions emission in glass.
Published: 2021

30. Monoterpenes: current knowledge on food source, metabolism, and health effects

Author: Eduardo Purgatto, Brunna Genaro, José de Alvarenga, Claudine Manach, Jarlei Fiamoncini, Bruna Lamesa Costa, Universidade de São Paulo (USP), University of São Paulo (USP), Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)2019/11324-82019/24267-22013/07914-82018/19189-0French National Research Agency (ANR) ANR-19HDH2-0002-01, and Universidade de São Paulo = University of São Paulo (USP)
Subjects: Monoterpene, Energy metabolism, Dietary monoterpenes, Biology, Gut flora, 01 natural sciences, Industrial and Manufacturing Engineering, metabolic syndrome, 03 medical and health sciences, Biotransformation, energy metabolism, Food science, BIOTRANSFORMAÇÃO, 030304 developmental biology, 2. Zero hunger, Food Preservatives, 0303 health sciences, 010401 analytical chemistry, General Medicine, Metabolism, Antimicrobial, biology.organism_classification, 0104 chemical sciences, 3. Good health, Bioavailability, monoterpene biotransformation, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Food Science
Abstract: International audience; Monoterpenes, volatile metabolites produced by plants, are involved in the taste and aroma perception of fruits and vegetables and have been used for centuries in gastronomy, as food preservatives and for therapeutic purposes. Biological activities such as antimicrobial, analgesic and anti-inflammatory are well-established for some of these molecules. More recently, the ability of monoterpenes to regulate energy metabolism, and exert antidiabetic, anti-obesity and gut microbiota modulation activities have been described. Despite their promising health effects, the lack of reliable quantification of monoterpenes in food, hindered the investigation of their role as dietary bioactive compounds in epidemiological studies. Moreover, only few studies have documented the biotransformation of these compounds and identified the monoterpene metabolites with biological activity. This review presents up-to-date knowledge about the occurrence of monoterpenes in food, their bioavailability and potential role in the modulation of intermediate metabolism and inflammation, focusing on novel findings of molecular mechanisms, underlining research gaps and new avenues to be explored.
Published: 2021

31. ATP2, The essential P4-ATPase of malaria parasites, catalyzes lipid-stimulated ATP hydrolysis in complex with a Cdc50 β-subunit

Author: Lamy, Anaïs, Macarini-Bruzaferro, Ewerton, Dieudonné, Thibaud, Perálvarez-Marín, Alex, Lenoir, Guillaume, Montigny, Cédric, le Maire, Marc, Vázquez-Ibar, José Luis, Department of Medical Biochemistry and Biophysics and Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Department of Clinical Medicine (FMUSP), University of São Paulo São Paulo, Brazil., Biophysics Unit, Department of Biochemistry and Molecular Biology, School of Medicine, Universitat Autònoma de Barcelona, Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Universite Paris-Saclay, 91198 ´ Gif-sur-Yvette, France, Institute for Integrative Biology of the Cell [Gif-sur-Yvette] (I2BC), Umeå University, University of São Paulo (USP), Aarhus University [Aarhus], Universitat Autònoma de Barcelona (UAB), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), ANR-18-CE11-0009,LYSOTRANS,Dynamique des transporteurs lysosomaux d'acides aminés(2018), and Universidade de São Paulo = University of São Paulo (USP)
Subjects: Models, Molecular, Plasmodium, Protein Conformation, Lipid flippase, Protozoan Proteins, malaria, Saccharomyces cerevisiae, membrane transport proteins, Membrane transport proteins, Adenosine Triphosphate, Transformation, Genetic, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Cloning, Molecular, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Phospholipids, ComputingMilieux_MISCELLANEOUS, lipid flippase, PfATP2, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Hydrolysis, Biochemistry and Molecular Biology, heterologous expression, Membrane Proteins, Biological Transport, Recombinant Proteins, Malaria, [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, Proton-Translocating ATPases, P4-ATPases, Heterologous expression, Biokemi och molekylärbiologi, Research Article, Protein Binding
Abstract: International audience; Gene targeting approaches have demonstrated the essential role for the malaria parasite of membrane transport proteins involved in lipid transport and in the maintenance of membrane lipid asymmetry, representing emerging oportunites for therapeutical intervention. This is the case of ATP2, a Plasmodium-encoded 4 P-type ATPase (P4-ATPase or lipid flippase), whose activity is completely irreplaceable during the asexual stages of the parasite. Moreover, a recent chemogenomic study has situated ATP2 as the possible target of two antimalarial drug candidates. In eukaryotes, P4-ATPases assure the asymmetric phospholipid distribution in membranes by translocating phospholipids from the outer to the inner leaflet. In this work, we have used a recombinantly-produced P. chabaudi ATP2 (PcATP2), to gain insights into the function and structural organization of this essential transporter. Our work demonstrates that PcATP2 associates with two of the three Plasmodium-encoded Cdc50 proteins: PcCdc50B and PcCdc50A. Purified PcATP2/PcCdc50B complex displays ATPase activity in the presence of either phosphatidylserine or phosphatidylethanolamine. In addition, this activity is upregulated by phosphatidylinositol 4-phosphate. Overall, our work describes the first biochemical characterization of a Plasmodium lipid flippase, a first step towards the understanding of the essential physiological role of this transporter and towards its validation as a potential antimalarial drug target.
Published: 2021

32. miRNAs may play a major role in the control of gene expression in key pathobiological processes in Chagas disease cardiomyopathy

Author: Ronaldo Honorato Barros Santos, Fernando Bacal, Frederico Moraes Ferreira, Jorge Kalil, Amanda Farage Frade, Pauline Brochet, Vanessa Escolano Maso, João Paulo Silva Nunes, Laurie Laugier, Helder I. Nakaya, Ludmila Rodrigues Pinto Ferreira, Priscila Camillo Teixeira, Edecio Cunha-Neto, Sandrine Cabantous, Christophe Chevillard, Rafael Almeida Ribeiro, Edimar Alcides Bocchi, Darlan da Silva Cândido, Génétique et immunologie des maladies parasitaires (GIMP), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of São Paulo (USP), Theories and Approaches of Genomic Complexity (TAGC), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Universidade de São Paulo = University of São Paulo (USP)
Subjects: 0301 basic medicine, Chagas Cardiomyopathy, Physiology, [SDV]Life Sciences [q-bio], RC955-962, Cardiomyopathy, 030204 cardiovascular system & hematology, Biochemistry, Pathogenesis, 0302 clinical medicine, Mathematical and Statistical Techniques, Fibrosis, Arctic medicine. Tropical medicine, Immune Physiology, Gene expression, Medicine and Health Sciences, Immune Response, Energy-Producing Organelles, Regulation of gene expression, Innate Immune System, Principal Component Analysis, Statistics, Heart, 3. Good health, Mitochondria, Nucleic acids, Infectious Diseases, Physical Sciences, Cytokines, medicine.symptom, Public aspects of medicine, RA1-1270, Anatomy, Cellular Structures and Organelles, Research Article, Myocarditis, Immunology, Inflammation, Biology, Bioenergetics, Research and Analysis Methods, 03 medical and health sciences, Signs and Symptoms, microRNA, medicine, Genetics, Humans, Statistical Methods, Non-coding RNA, Natural antisense transcripts, Biology and life sciences, Genome, Human, Myocardium, Public Health, Environmental and Occupational Health, EXPRESSÃO GÊNICA, Cell Biology, Molecular Development, medicine.disease, Gene regulation, MicroRNAs, 030104 developmental biology, Gene Expression Regulation, Immune System, Multivariate Analysis, Chronic Disease, Cancer research, Cardiovascular Anatomy, RNA, Clinical Medicine, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Mathematics, Developmental Biology
Abstract: Chronic Chagas disease cardiomyopathy (CCC), an especially aggressive inflammatory dilated cardiomyopathy caused by lifelong infection with the protozoan Trypanosoma cruzi, is a major cause of cardiomyopathy in Latin America. Although chronic myocarditis may play a major pathogenetic role, little is known about the molecular mechanisms responsible for its severity. The aim of this study is to study the genes and microRNAs expression in tissues and their connections in regards to the pathobiological processes. To do so, we integrated for the first time global microRNA and mRNA expression profiling from myocardial tissue of CCC patients employing pathways and network analyses. We observed an enrichment in biological processes and pathways associated with the immune response and metabolism. IFNγ, TNF and NFkB were the top upstream regulators. The intersections between differentially expressed microRNAs and differentially expressed target mRNAs showed an enrichment in biological processes such as Inflammation, inflammation, Th1/IFN-γ-inducible genes, fibrosis, hypertrophy, and mitochondrial/oxidative stress/antioxidant response. MicroRNAs also played a role in the regulation of gene expression involved in the key cardiomyopathy-related processes fibrosis, hypertrophy, myocarditis and arrhythmia. Significantly, a discrete number of differentially expressed microRNAs targeted a high number of differentially expressed mRNAs (>20) in multiple processes. Our results suggest that miRNAs orchestrate expression of multiple genes in the major pathophysiological processes in CCC heart tissue. This may have a bearing on pathogenesis, biomarkers and therapy., Author summary Chronic Chagas disease cardiomyopathy (CCC), an aggressive dilated cardiomyopathy caused by Trypanosoma cruzi, is a major cause of cardiomyopathy in Latin America. Little is known about the molecular mechanisms responsible for its severity. Authors study the possible role of microRNAs in the regulation of gene expression in relevant pathways and pathobiological processes. Differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs) -small RNAs that can regulate gene expression—associated to severe cardiomyopathy development. The inflammatory mediator Interferon-γ was the most likely inducer of gene expression in CCC, and most genes belonged to the immune response, fibrosis, hypertrophy and mitochondrial metabolism. A discrete number of differentially expressed mRNAs targeted a high number of differentially expressed mRNAs in multiple processes. Moreover, several pathways had multiple targets regulated by microRNAs, suggesting synergic effect. Results suggest that microRNAs orchestrate expression of multiple genes in the major pathophysiological processes in CCC heart tissue.
Published: 2020

33. Drier tropical and subtropical Southern Hemisphere in the mid-Pliocene Warm Period

Author: Wing-Le Chan, Yoichi Kame, Deepak Chandan, Andréa S. Taschetto, Ilana Wainer, Ayako Abe-Ouchi, W. Richard Peltier, Christian Stepanek, Alex Sen Gupta, Esther C. Brady, Bette L. Otto-Bliesner, Camille Contoux, Ning Tan, Julia Tindall, Gabriel M. Pontes, Ran Feng, Qiong Zhang, Zhongshi Zhang, Gerrit Lohmann, Stephen J. Hunter, University of São Paulo (USP), Climate Change Research Centre [Sydney] (CCRC), University of New South Wales [Sydney] (UNSW), Universidade de São Paulo (USP), Center for Climate System Research [Kashiwa] (CCSR), The University of Tokyo (UTokyo), National Center for Atmospheric Research [Boulder] (NCAR), University of Toronto, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Modélisation du climat (CLIM), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Center for Marine Environmental Sciences [Bremen] (MARUM), Universität Bremen, Department of Physics [Toronto], School of Earth and Environment [Leeds] (SEE), University of Leeds, Beijing Institute of Technology (BIT), Nansen-Zhu International Research Centre, Institute of Atmospheric Physics [Beijing] (IAP), Chinese Academy of Sciences [Beijing] (CAS)-Chinese Academy of Sciences [Beijing] (CAS), Universidade de São Paulo = University of São Paulo (USP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Atmospheric circulation, lcsh:Medicine, Subtropics, Palaeoclimate, Convergence zone, Article, 03 medical and health sciences, 0302 clinical medicine, Atmospheric science, Climate change, Precipitation, lcsh:Science, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, Southern Hemisphere, [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, Multidisciplinary, lcsh:R, Northern Hemisphere, MUDANÇA CLIMÁTICA, Tropics, 030104 developmental biology, 13. Climate action, Climatology, Environmental science, Climate model, lcsh:Q, Climate sciences, 030217 neurology & neurosurgery
Abstract: Thermodynamic arguments imply that global mean rainfall increases in a warmer atmosphere; however, dynamical effects may result in more significant diversity of regional precipitation change. Here we investigate rainfall changes in the mid-Pliocene Warm Period (~ 3 Ma), a time when temperatures were 2–3ºC warmer than the pre-industrial era, using output from the Pliocene Model Intercomparison Projects phases 1 and 2 and sensitivity climate model experiments. In the Mid-Pliocene simulations, the higher rates of warming in the northern hemisphere create an interhemispheric temperature gradient that enhances the southward cross-equatorial energy flux by up to 48%. This intensified energy flux reorganizes the atmospheric circulation leading to a northward shift of the Inter-Tropical Convergence Zone and a weakened and poleward displaced Southern Hemisphere Subtropical Convergences Zones. These changes result in drier-than-normal Southern Hemisphere tropics and subtropics. The evaluation of the mid-Pliocene adds a constraint to possible future warmer scenarios associated with differing rates of warming between hemispheres.
Published: 2020

34. The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline

Author: Alexandre Demoule, Dipayan Chaudhuri, Carol L. Hodgson, Antonio Pesenti, Jean-Damien Ricard, Karen E. A. Burns, Armand Dessap-Mekontso, Ewan C. Goligher, Jordi Mancebo, Alain Mercat, M. Elizabeth Wilcox, Gilda Cinnella, Tommaso Mauri, Arthur S. Slutsky, Lamia Ouanes-Besbes, Samir Jaber, Renee D. Stapleton, Massimo Antonelli, David Granton, Salvatore Maurizio Maggiore, Jean-Pierre Frat, Dominic Xiang Wang, Michela Rauseo, Laurent Brochard, Arnaud W. Thille, Charles D. Gomersall, Sharon Einav, John F. Fraser, Daniel Talmor, Elie Azoulay, Bram Rochwerg, Yigal Helviz, Giacomo Grasselli, Elisabeth D. Riviello, Nuttapol Rittayamai, Oriol Roca, Carlos Roberto Ribeiro de Carvalho, Sameer Jog, Gonzalo Hernández, McMaster University [Hamilton, Ontario], Shaare Zedek Medical Center [Jerusalem, Israel], The Hebrew University of Jerusalem (HUJ), Hospital Universitari Sant Pau, Barcelona, Università degli Studi di Milano [Milano] (UNIMI), Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, University Health Network, University of Toronto, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital Louis Mourier - AP-HP [Colombes], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC)-Université Sorbonne Paris Nord, Siriraj Hospital, Mahidol University, Mahidol University [Bangkok], Vall d'Hebron University Hospital [Barcelona], Vall d’Hebron Research Institute (VHIR), Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III [Madrid] (ISC), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Università degli studi 'G. d'Annunzio' Chieti-Pescara [Chieti-Pescara] (Ud'A), Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de Pneumologie et Réanimation Médicale [CHU Pitié-Salpêtrière] (Département ' R3S '), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Monash University [Melbourne], Alfred Health, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Hopital Saint-Louis [AP-HP] (AP-HP), CHU Fattouma Bourguiba [Monastir] (HFB), Université de Monastir - University of Monastir (UM), Università degli Studi di Foggia - University of Foggia, University of São Paulo (USP), Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), University of Queensland [Brisbane], The Prince Charles Hospital, Centre hospitalier universitaire de Poitiers (CHU Poitiers), CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), The Chinese University of Hong Kong [Hong Kong], Hospital Virgen de la Salud, Toledo, Spain, Deenanath Mangeshkar Hospital [Pune], Beth Israel Deaconess Medical Center [Boston] (BIDMC), Harvard Medical School [Boston] (HMS), Keenan Research Centre of the Li Ka Shing Knowledge Institute [Toronto], St. Michael's Hospital, Larner College of Medicine [University of Vermont, Burlington], University of Vermont [Burlington], Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Fondazione 'Policlinico Universitario A. Gemelli' [Rome], Università cattolica del Sacro Cuore [Roma] (Unicatt), Neurophysiologie Respiratoire Expérimentale et Clinique, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), The Prince Charles Hospital [Queensland, Australia] (Metro North Hospital and Health Service), Università degli Studi di Milano = University of Milan (UNIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Università degli Studi di Foggia = University of Foggia (Unifg), and Universidade de São Paulo = University of São Paulo (USP)
Subjects: Adult, medicine.medical_specialty, medicine.medical_treatment, Conference Reports and Expert Panel, [SDV]Life Sciences [q-bio], Peri-intubation, Respiratory failure, Critical Care and Intensive Care Medicine, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Extubation, Anesthesiology, Oxygen therapy, Settore MED/41 - ANESTESIOLOGIA, Medicine, Cannula, Humans, Postoperative, Mortality, Intensive care medicine, ComputingMilieux_MISCELLANEOUS, Noninvasive Ventilation, business.industry, Oxygen Inhalation Therapy, 030208 emergency & critical care medicine, Guideline, 3. Good health, Clinical Practice, Oxygen, High flow nasal cannula, 030228 respiratory system, Cardiothoracic surgery, Airway Extubation, business, High flow, Respiratory Insufficiency, Nasal cannula
Abstract: Purpose High flow nasal cannula (HFNC) is a relatively recent respiratory support technique which delivers high flow, heated and humidified controlled concentration of oxygen via the nasal route. Recently, its use has increased for a variety of clinical indications. To guide clinical practice, we developed evidence-based recommendations regarding use of HFNC in various clinical settings. Methods We formed a guideline panel composed of clinicians, methodologists and experts in respiratory medicine. Using GRADE, the panel developed recommendations for four actionable questions. Results The guideline panel made a strong recommendation for HFNC in hypoxemic respiratory failure compared to conventional oxygen therapy (COT) (moderate certainty), a conditional recommendation for HFNC following extubation (moderate certainty), no recommendation regarding HFNC in the peri-intubation period (moderate certainty), and a conditional recommendation for postoperative HFNC in high risk and/or obese patients following cardiac or thoracic surgery (moderate certainty). Conclusions This clinical practice guideline synthesizes current best-evidence into four recommendations for HFNC use in patients with hypoxemic respiratory failure, following extubation, in the peri-intubation period, and postoperatively for bedside clinicians. Electronic supplementary material The online version of this article (10.1007/s00134-020-06312-y) contains supplementary material, which is available to authorized users.
Published: 2020

35. Improving mobile app development using transpilers with maintainable outputs

Author: Vinícius Jorge Vendramini, Grégory Mounié, Alfredo Goldman, Departamento de Ciência da Computação [São Paulo] (IME/USP), Universidade de São Paulo (USP), Department of Computer Science (IME-USP), University of São Paulo (USP), Université Grenoble Alpes (UGA), Data Aware Large Scale Computing (DATAMOVE ), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'Informatique de Grenoble (LIG), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), ACM, CAPES-COFECUB: CHOOSING: Cooperation on Hybrid cOmputing clOuds for energy SavING, and Universidade de São Paulo = University of São Paulo (USP)
Subjects: Swift, Computer science, 02 engineering and technology, mobile, [INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE], computer.software_genre, Kotlin, 0202 electrical engineering, electronic engineering, information engineering, [INFO]Computer Science [cs], Android (operating system), computer.programming_language, Codebase, transcompilers, business.industry, 020206 networking & telecommunications, Readability, transpilers, Obstacle, 020201 artificial intelligence & image processing, Compiler, Software engineering, business, computer, Machine code
Abstract: National audience; Mobile application developers often target both iOS and Android in an effort to extend their target user base. There are several tools that can aid this development effort, allowing developers to maintain a single codebase for both platforms instead of two. These tools often face a few shortcomings, of which two are noteworthy: they are hard-to-replace dependencies in the codebase, and often present some type of obstacle for integrating platform-independent native code with the shared codebase. The goal of this work is to propose a new approach to creating cross-platform development tools that improves on these two aspects, and to analyze the viability of a real-world implementation of the proposed approach. An analysis of the current state of the practice indicates cross-platform compilers as a promising direction, and a study is made on the common concerns and challenges faced when developing these compilers. Based on these analyses, this work proposes the creation of a compiler that translates one platform's hand-written native code into maintainable native code for the other platform. The feasibility of implementing this approach is tested with the development of a proof-of-concept compiler from Swift to Kotlin. An analysis is made on the readability of the resulting prototype's output code, as well as other relevant metrics. The conclusion is that, while some trade-offs might be necessary, such an approach is viable if applied in an adequate ecosystem.
Published: 2020

36. Molecular Phylogeny and taxonomy of a new Myxobolus species from the endangered ornamental fish, Otocinclus cocama endemic to Peru: A host-parasite coextinction approach

Author: Luis Ramiro Luna Espinoza, Patrick D. Mathews, André C. Morandini, Anai P. Flores-Gonzales, Omar Mertins, Fabienne Audebert, Tiago Milanin, University of São Paulo (USP), Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Federal University of Sao Paulo (Unifesp), Universidad Nacional Mayor de San Marcos (UNMSM), Universidade do Estado do Amapá (UEAP), and Universidade de São Paulo = University of São Paulo (USP)
Subjects: Gills, 0301 basic medicine, Parasitic Diseases, Animal, Veterinary (miscellaneous), Loricariidae, [SDV]Life Sciences [q-bio], 030231 tropical medicine, Endangered species, Zoology, Fresh Water, Otocinclus, Myxosporea, Fish Diseases, 03 medical and health sciences, 0302 clinical medicine, Peru, Animals, 14. Life underwater, Phylogeny, ComputingMilieux_MISCELLANEOUS, biology, [SDV.BA]Life Sciences [q-bio]/Animal biology, South America, 030108 mycology & parasitology, biology.organism_classification, MYXOZOA, 6. Clean water, Genetic divergence, Infectious Diseases, Myxobolus, Insect Science, Molecular phylogenetics, Parasitology, Taxonomy (biology)
Abstract: A new Myxobolus species is described infecting gill filaments of the endangered ornamental fish Otocinclus cocama from Peruvian Amazon. In a total of 35 fish examined, five (14.3%) had myxozoan plasmodia. Taxonomic analysis was performed integrating multiple characters, including morphometrical, biological traits, ssrDNA sequence data and host ecological characters. Myxospores of M. iquitoensis n. sp. were ovoid in shape from the frontal view and measured 17.6±1.2 µm (16.2-19.8 µm) in length and 10.5±0.7 µm (9.8-12 µm) in width. The two polar capsules were elongate in shape, equal in size and occupying almost half of the myxospore body. They measured 8.7±0.4 µm (6.9-9.3 µm) in length and 3.3±0.2 µm (3-3.6 µm) in width. The polar tubules presented six to seven turns. Molecular phylogenetic analysis revealed that the obtained ssrDNA sequence did not match any existing sequences in GenBank but showed M. iquitoensis n. sp. to be a close species of M. figueirae. Nonetheless, the ssrDNA sequences of those species show large genetic divergence. This is the first description and phylogenetic study of a myxozoan parasitizing fish of the genus Otocinclus from South America, as well the first report of these parasites infecting a fish belonging to the Loricariidae family from Amazon basin. Considering the endangered status of the host, the high degree of host-specificity of freshwater histozoic myxobolids, the low occurrence shown by the new myxozoan, and the fact that this is the only host known for this myxozoan, the conservation status of the new species of myxozoan is likely to be connected to the future survival of its host.
Published: 2020

37. SNP‐HLA Reference Consortium (SHLARC): HLA and SNP data sharing for promoting MHC‐centric analyses in genomics

Author: Vince, Nicolas, Douillard, Venceslas, Geffard, Estelle, Meyer, Diogo, Castelli, Erick C., Mack, Steven J., Limou, Sophie, Gourraud, Pierre‐Antoine, Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Universidade de São Paulo = University of São Paulo (USP), Universidade Estadual Paulista Júlio de Mesquita Filho = São Paulo State University (UNESP), University of California [San Francisco] (UC San Francisco), University of California (UC), École Centrale de Nantes (ECN), Vince, Nicolas, University of São Paulo (USP), University of California [San Francisco] (UCSF), and University of California
Subjects: [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, [SDV.IMM] Life Sciences [q-bio]/Immunology, [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2020

38. Corrigendum: Polymorphisms in Genes Affecting Interferon-γ Production and Th1 T Cell Differentiation Are Associated With Progression to Chagas Disease Cardiomyopathy

Author: Amanda Farage Frade-Barros, Barbara Maria Ianni, Sandrine Cabantous, Cristina Wide Pissetti, Bruno Saba, Hui Tzu Lin-Wang, Paula Buck, José Antonio Marin-Neto, André Schmidt, Fabrício Dias, Mario Hiroyuki Hirata, Marcelo Sampaio, Abílio Fragata, Alexandre Costa Pereira, Eduardo Donadi, Virmondes Rodrigues, Jorge Kalil, Christophe Chevillard, Edecio Cunha-Neto, University of São Paulo School of Medicine, Génétique et immunologie des maladies parasitaires (GIMP), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Universidade Federal do Triângulo Mineiro (UFTM), Instituto de Cardiologia Dante Pazzanese (IDPC), University of São Paulo (USP), Theories and Approaches of Genomic Complexity (TAGC), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidade de São Paulo = University of São Paulo (USP), and Spinelli, Lionel
Subjects: lcsh:Immunologic diseases. Allergy, 0303 health sciences, Chagas disease, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [SDV]Life Sciences [q-bio], Immunology, IL 10, IFN, IL4, susceptibility, 3. Good health, [SDV] Life Sciences [q-bio], DOENÇAS CARDIOVASCULARES, 03 medical and health sciences, 0302 clinical medicine, Immunology and Allergy, IL12, lcsh:RC581-607, cardiomyopathy, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030304 developmental biology, 030215 immunology
Abstract: International audience
Published: 2020

39. Compressed k-Nearest Neighbors Ensembles for Evolving Data Streams

Author: Bahri, Maroua, Maniu, Silviu, Bifet, Albert, de Mello, Rodrigo Fernandes, Tziortziotis, Nikolaos, Data, Intelligence and Graphs (DIG), Laboratoire Traitement et Communication de l'Information (LTCI), Institut Mines-Télécom [Paris] (IMT)-Télécom Paris-Institut Mines-Télécom [Paris] (IMT)-Télécom Paris, Données et Connaissances Massives et Hétérogènes (LRI) (LaHDAK - LRI), Laboratoire de Recherche en Informatique (LRI), CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Value from Data (VALDA ), Département d'informatique - ENS Paris (DI-ENS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria), University of Waikato [Hamilton], Universidade de São Paulo = University of São Paulo (USP), Tradelab, This work was done in the context of IoTA AAP Emergence Digi-Cosme Project and was funded by Labex DigiCosme, Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Inria de Paris, University of São Paulo (USP), Département d'informatique de l'École normale supérieure (DI-ENS), École normale supérieure - Paris (ENS Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)
Subjects: [INFO.INFO-DB]Computer Science [cs]/Databases [cs.DB], [INFO.INFO-WB]Computer Science [cs]/Web, [INFO.INFO-SI]Computer Science [cs]/Social and Information Networks [cs.SI], [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract: International audience; The unbounded and multidimensional nature, the evolution of data distributions with time, and the requirement of singlepass algorithms comprise the main challenges of data stream classification, which makes it impossible to infer learning models in the same manner as for batch scenarios. Data dimensionality reduction arises as a key factor to transform and select only the most relevant features from those streams in order to reduce algorithm space and time demands. In that context, Compressed Sensing (CS) encodes an input signal into lower-dimensional space, guaranteeing its reconstruction up to some distortion factor. This paper employs CS on data streams as a pre-processing step to support a k-Nearest Neighbors (kNN) classification algorithm, one of the most often used algorithms in the data stream mining area-all this while ensuring the key properties of CS hold. Based on topological properties, we show that our classification algorithm also preserves the neighborhood (withing an factor) of kNN after reducing the stream dimensionality with CS. As a consequence, end-users can set an acceptable error margin while performing such projections for kNN. For further improvements, we incorporate this method into an ensemble classifier, Leveraging Bagging, by combining a set of different CS matrices which increases the diversity inside the ensemble. An extensive set of experiments is performed on various datasets, and the results were compared against those yielded by current state-of-the-art approaches, confirming the good performance of our approaches.
Published: 2020

40. Occupational socioeconomic risk associations for head and neck cancer in Europe and South America: individual participant data analysis of pooled case-control studies within the INHANCE Consortium

Author: Alexander W. Daudt, Kristina Kjærheim, Paolo Boffetta, Antonio Agudo, Leticia Fernandez, Peter Thomson, Cristina Canova, Alastair Ross, Isabelle Stücker, Diego Serraino, David I. Conway, Marta Vilensky, Rosalina Jorge Koifman, Paul Brennan, Lorenzo Richiardi, Gary J. Macfarlane, Mia Hashibe, Thomas Behrens, Pagona Lagiou, Simone Benhamou, Claire M. Healy, Amy Lee Yuan-Chin, Maria Paula Curado, Victor Wünsch-Filho, Wolfgang Ahrens, Alex D. McMahon, Gwenn Menvielle, Ariana Znaor, Ivana Holcatova, Heribert Ramroth, Jan Hovanec, Danièle Luce, Ana M. B. Menezes, University of Glasgow, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, First Faculty of Medicine Charles University [Prague], University of Athens Medical School [Athens], Universita degli Studi di Padova, University of Turin, Trinity College Dublin, Cancer Registry of Norway, University of Aberdeen, The University of Hong Kong (HKU), L’Hospitalet de Llobregat [Barcelona, Spain], Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), CHU Pontchaillou [Rennes], Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Gustave Roussy (IGR), University of Heidelberg, Medical Faculty, Mount Sinai School of Medicine, Department of Psychiatry-Icahn School of Medicine at Mount Sinai [New York] (MSSM), University of Bologna, University of Buenos Aires [Argentina], Universidade Federal de Pelotas = Federal University of Pelotas (UFPel), Hospital de Clínicas de Porto Alegre (HCPA), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), University of São Paulo (USP), University of Utah School of Medicine [Salt Lake City], National Cancer Institute, NCI: R03CA113157, National Institute of Dental and Craniofacial Research, NIDCR: R03DE016611, European Commission, EC: IC18-CT97-0222, Agence Nationale de la Recherche, ANR, Fundação de Amparo à Pesquisa do Estado de São Paulo, FAPESP: 01/01768-2, Bundesministerium für Bildung und Forschung, BMBF: 01GB9702/3, Fondation pour la Recherche Médicale, FRM, Fondation ARC pour la Recherche sur le Cancer, ARC, Fondation de France, Ministère des Affaires Sociales et de la Santé, Fifth Framework Programme, FP5: FOR381.88, KFS1069-09-2000, QLK1-CT-2001-00182, Institut National Du Cancer, INCa, Fondo para la Investigación Científica y Tecnológica, FonCyT, Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, ANSES, Institut Gustave-Roussy: 88D28, Institut de Veille Sanitaire, InVS, Swiss Cancer Research Foundation: AKT 617, Conway D.I., Hovanec J., Ahrens W., Ross A., Holcatova I., Lagiou P., Serraino D., Canova C., Richiardi L., Healy C., Kjaerheim K., Macfarlane G.J., Thomson P., Agudo A., Znaor A., Brennan P., Luce D., Menvielle G., Stucker I., Benhamou S., Ramroth H., Boffetta P., Vilensky M., Fernandez L., Curado M.P., Menezes A., Daudt A., Koifman R., Wunsch-Filho V., Yuan-Chin A.L., Hashibe M., Behrens T., McMahon A.D., Università degli Studi di Padova = University of Padua (Unipd), Università degli studi di Torino = University of Turin (UNITO), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), University of Bologna/Università di Bologna, Universitad de Buenos Aires = University of Buenos Aires [Argentina], Universidade de São Paulo = University of São Paulo (USP), HAL UR1, Admin, and Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ)
Subjects: Data Analysis, medicine.medical_specialty, Epidemiology, Risk factors in diseases, Occupational prestige, [SDV]Life Sciences [q-bio], Socioeconomic Factor, Head cancer, socioeconomic, Cancer, Cancer Epidemiology, Occupational, Socioeconomic, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Epidemiology of cancer, medicine, Humans, 030212 general & internal medicine, Socioeconomic status, Càncer de cap, Original Research, business.industry, Factors de risc en les malalties, Prestige, Risk Factor, Head and neck cancer, Public Health, Environmental and Occupational Health, Case-control study, South America, medicine.disease, Neck cancer, Càncer de coll, [SDV] Life Sciences [q-bio], Europe, Data Analysi, Socioeconomic Factors, cancer: occupational, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Case-Control Studies, cancer epidemiology, business, Case-Control Studie, Psychosocial, Demography, Human
Abstract: BackgroundThe association between socioeconomic disadvantage (low education and/or income) and head and neck cancer is well established, with smoking and alcohol consumption explaining up to three-quarters of the risk. We aimed to investigate the nature of and explanations for head and neck cancer risk associated with occupational socioeconomic prestige (a perceptual measure of psychosocial status), occupational socioeconomic position and manual-work experience, and to assess the potential explanatory role of occupational exposures.MethodsPooled analysis included 5818 patients with head and neck cancer (and 7326 control participants) from five studies in Europe and South America. Lifetime job histories were coded to: (1) occupational social prestige—Treiman’s Standard International Occupational Prestige Scale (SIOPS); (2) occupational socioeconomic position—International Socio-Economic Index (ISEI); and (3) manual/non-manual jobs.ResultsFor the longest held job, adjusting for smoking, alcohol and nature of occupation, increased head and neck cancer risk estimates were observed for low SIOPS OR=1.88 (95% CI: 1.64 to 2.17), low ISEI OR=1.74 (95% CI: 1.51 to 1.99) and manual occupations OR=1.49 (95% CI: 1.35 to 1.64). Following mutual adjustment by socioeconomic exposures, risk associated with low SIOPS remained OR=1.59 (95% CI: 1.30 to 1.94).ConclusionsThese findings indicate that low occupational socioeconomic prestige, position and manual work are associated with head and neck cancer, and such risks are only partly explained by smoking, alcohol and occupational exposures. Perceptual occupational psychosocial status (SIOPS) appears to be the strongest socioeconomic factor, relative to socioeconomic position and manual/non-manual work.
Published: 2020

41. Persistent postoperative ascites successfully identified and treated with laparoscopic indocyanine green fluorescence

Author: Rodrigo Fernandes, Jesus Paula Carvalho, Ulysses Ribeiro, Andre Lopes, Cristina Anton, Alexandre Silva e Silva, Eric Leblanc, INSERM, Université de Lille, Universidade de São Paulo = University of São Paulo [USP], Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192, Universidade de São Paulo = University of São Paulo (USP), Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 (PRISM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)
Subjects: Indocyanine Green, medicine.medical_specialty, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Urology, Pelvis, 03 medical and health sciences, Lymphocele, Postoperative Complications, 0302 clinical medicine, Chylous ascites, Ascites, medicine, Humans, Coloring Agents, Chylous Ascites, Aorta, Ovarian Neoplasms, 030219 obstetrics & reproductive medicine, business.industry, Optical Imaging, Obstetrics and Gynecology, Cytoreduction Surgical Procedures, Middle Aged, medicine.disease, Lymphatic system, Oncology, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Lymph Node Excision, Female, Lymphadenectomy, medicine.symptom, Ovarian cancer, business, Complication, Indocyanine green fluorescence
Abstract: International audience; Lymphatic ascites after a lymphadenectomy due to disruption of lymphatic vessels is a complication reported to happen in 2.7% of those procedures.1–3 There are several types of lymphatic leakage reported in the literature such as lymphorrhea, lymphocele, lymphatic ascites, chylous ascites, and lymphatic fistula. Medical treatment is the primary treatment of choice and has been reported to cure ascites in 66% to 77% of cases.1 Surgical treatment to identify the leakage site should not be considered as the first choice and is reserved if medical treatment fails to solve it.1 4 Indocyanine green (ICG) and fluorescence imaging (FI) have been vastly used for different purposes including sentinel lymph node identification for different types of cancer, retina evaluation, and organ perfusion before resection. In addition, ICG and FI have potential to solve contemporary problems in gynecologic oncology and may be used to evaluate perfusion of colorectal anastomosis or uterine perfusion after radical trachelectomy.5 6 In this video we present a case where ICG and FI were used to help identify the precise site of lymphatic leakage and successfully solve it. Different from previous authors who published ICG interdigital foot injection, we demonstrate an alternative application at the proximal part of the thigh.7A 59-year-old woman diagnosed with high-grade serous ovarian carcinoma FIGO stage IIIC, underwent upfront debulking surgery with total hysterectomy, bilateral adnexectomy, omentectomy, and partial lymphadenectomy in another hospital.The patient was referred to our institution and underwent six cycles of chemotherapy with carboplatin-paclitaxel, however she persisted with enlarged pelvic and para-aortic lymph nodes, suspicious for secondary involvement without any other sites of metastasis. We decided to perform systematic pelvic and para-aortic lymphadenectomy. A few days after the surgery the patient developed ascites confirmed by the clinical aspect and biochemical evaluation of the fluid.Conservative treatment consisting of parenteral nutrition, a low-fat diet with medium-chain triglycerides, and several percutaneous drainages were unsuccessful. Then we decided to perform laparoscopy, ICG, and FI to fix the leakage.During the procedure 1.2 liters of lymphatic ascites were drained. An injection of 1 mL of ICG in three sites of the proximal part of both thighs was performed and after 10 min the use of near infrared fluorescence successfully identified the active leakage site. Several metal clips were used to stop the leakage.After surgery the patient was discharged with no further complications. Long-term follow-up demonstrated no more ascites.The use of laparoscopy and ICG subcutaneous injection appears as a promising technique to identify active lymphatic leakage and treat it surgically. The injection of ICG to the thigh appears to be an alternative to interdigital foot injection.
Published: 2020

42. A Multistage Formulation Based on Full-Length CSP and AMA-1 Ectodomain of Plasmodium vivax Induces High Antibody Titers and T-cells and Partially Protects Mice Challenged with a Transgenic Plasmodium berghei Parasite

Author: Luciana Campos Lima, Katia Sanches Françoso, Eduardo Aliprandini, Rogerio Amino, Rodolfo F. Marques, Anna Caroline Campos Aguiar, Laurent Rénia, Irene S. Soares, Tarsila Mendes de Camargo, Alba Marina Gimenez, Dhelio Batista Pereira, University of São Paulo (USP), Infection et Immunité paludéennes - Malaria Infection and Immunity, Institut Pasteur [Paris], Centro de Pesquisas em Medicina Tropical [Porto Velho, Brazil] (CEPEM), Singapore Immunology Network (SIgN), This study was supported by grants from the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP grants 2012/13032-5, 2014/18102-7, and 2018/17364-9), the National Institute for Vaccine Development and Technology (CNPq—INCTV), Institut Pasteur—Paris, and the French Government’s Investissement d’Avenir program, Laboratoire d’Excellence 'Integrative Biology of Emerging Infectious Diseases' (grant ANR-10-LABX-62-IBEID). L.C.L., A.M.G., and T.M.C. were recipients of fellowship from FAPESP, R.F.M. from Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior, and I.S.S. from CNPq., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Universidade de São Paulo = University of São Paulo (USP), and Institut Pasteur [Paris] (IP)
Subjects: 0301 basic medicine, Microbiology (medical), malaria vaccine, [SDV]Life Sciences [q-bio], 030231 tropical medicine, Plasmodium vivax, Microbiology, 03 medical and health sciences, 0302 clinical medicine, Antigen, Virology, parasitic diseases, Plasmodium berghei, Apical membrane antigen 1, lcsh:QH301-705.5, biology, Malaria vaccine, Antibody titer, ANTIMALÁRICOS, biology.organism_classification, 3. Good health, Circumsporozoite protein, 030104 developmental biology, lcsh:Biology (General), apical membrane antigen 1, biology.protein, Antibody, circumsporozoite protein, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Infections with Plasmodium vivax are predominant in the Americas, representing 75% of malaria cases. Previously perceived as benign, malaria vivax is, in fact, a highly debilitating and economically important disease. Considering the high complexity of the malaria parasite life cycle, it has been hypothesized that an effective vaccine formulation against Plasmodium should contain multiple antigens expressed in different parasite stages. Based on that, we analyzed a recombinant P. vivax vaccine formulation mixing the apical membrane antigen 1 ectodomain (PvAMA-1) and a full-length circumsporozoite protein (PvCSP-AllFL) previously studied by our group, which elicits a potent antibody response in mice. Genetically distinct strains of mice (C57BL/6 and BALB/c) were immunized with the proteins, alone or in combination, in the presence of poly(I:C) adjuvant, a TLR3 agonist. In C57BL/6, high-antibody titers were induced against PvAMA-1 and the three PvCSP variants (VK210, VK247, and P. vivax-like). Meanwhile, mixing PvAMA-1 with PvCSP-AllFL had no impact on total IgG antibody titers, which were long-lasting. Moreover, antibodies from immunized mice recognized VK210 sporozoites and blood-stage parasites by immunofluorescence assay. However, in the BALB/c model, the antibody response against PvCSP-AllFL was relatively low. PvAMA-1-specific CD3+CD4+ and CD3+CD8+ T-cell responses were observed in C57BL/6 mice, and the cellular response was impaired by PvCSP-AllFL combination. More relevant, the multistage vaccine formulation provided partial protection in mice challenged with a transgenic Plasmodium berghei sporozoite expressing the homologous PvCSP protein.
Published: 2020
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43. Ultra-Processed Food Consumption among the Paediatric Population: An Overview and Call to Action from the European Childhood Obesity Group

Author: David Thivel, Carlos Augusto Monteiro, Emma Boyland, Marie-Laure Frelut, Artur Mazur, Neha Khandpur, Daniela Neri, Daniel Weghuber, University of São Paulo (USP), Rzeszow University, Centre thérapeutique pédiatrique, Croix rouge française, School of Psychology, University of Liverpool, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), and Universidade de São Paulo = University of São Paulo (USP)
Subjects: Pediatric Obesity, Adolescent, 030309 nutrition & dietetics, Food Handling, MEDLINE, Medicine (miscellaneous), Childhood obesity, Food handling, 03 medical and health sciences, 0302 clinical medicine, Environmental health, medicine, Humans, 030212 general & internal medicine, Child, ComputingMilieux_MISCELLANEOUS, 2. Zero hunger, Consumption (economics), 0303 health sciences, Nutrition and Dietetics, business.industry, medicine.disease, 3. Good health, Call to action, Diet, Europe, Food processing, Fast Foods, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Paediatric population, Fast foods
Abstract: International audience
Published: 2020

44. Do you Play or Do you Train? Insights From Individual Sports for Training Load and Injury Risk Management in Team Sports Based on Individualization

Author: Daniel Boullosa, Arturo Casado, João Gustavo Claudino, Pedro Jiménez-Reyes, Guillaume Ravé, Adrián Castaño-Zambudio, Adriano Lima-Alves, Silvio Assis de Oliveira, Gregory Dupont, Urs Granacher, Hassane Zouhal, James Cook University (JCU), Universidade Federal de Mato Grosso do Sul (UFMS), University of Isabel I (UI1), University of São Paulo (USP), Universidad Rey Juan Carlos [Madrid] (URJC), Federal University of Minas Gerais (UFMG), Universität Potsdam, Laboratoire Mouvement Sport Santé (M2S), École normale supérieure - Cachan (ENS Cachan)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Deutsche Forschungsgemeinschaft (DFG)German Research Foundation (DFG), University of Potsdam, Germany, CNPqNational Council for Scientific and Technological Development (CNPq), Universidade de São Paulo = University of São Paulo (USP), Universidade Federal de Minas Gerais = Federal University of Minas Gerais [Belo Horizonte, Brazil] (UFMG), French Institute of Sport (INSEP), Laboratory Sport, Expertise and Performance (EA7370) (SEP (EA7370)), Institut national du sport, de l'expertise et de la performance (INSEP), University of Potsdam = Universität Potsdam, and Université de Rennes (UR)-École normale supérieure - Rennes (ENS Rennes)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Opinion, chronic workload ratio, lcsh:QP1-981, Physiology, [SDV]Life Sciences [q-bio], injury prevention, acute:chronic workload ratio, evolutionary biology, acute, lcsh:Physiology, periodization, physical fitness, training monitoring, sport physiology, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2020

45. Plasmon-enhanced electrocatalytic oxygen reduction in alkaline media on gold nanohole electrodes

Author: Anderson G. M. da Silva, Robert Wojcieszak, Bahram Djafari-Rouhani, Sorin Melinte, Palaniappan Subramanian, Dalila Meziane, Noual Adnane, Franck Dumeignil, Sabine Szunerits, Liuqing Pang, Georgiana Sandu, Sébastien Paul, Vladyslav Mishyn, Rabah Boukherroub, Tamazouzt Nait Saada, Université de Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN], Université Mouloud Mammeri [Tizi Ouzou] [UMMTO], Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS], Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Laboratoire de Chimie appliquée & génie chimique [Tizi-Ouzou] (LCAGC), Université Mouloud Mammeri [Tizi Ouzou] (UMMTO), Institute of Chemistry [University of São Paulo] | Instituto de Química [Universidade de São Paulo], Universidade de São Paulo = University of São Paulo (USP), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Université Mohammed Premier [Oujda], Physique - IEMN (PHYSIQUE - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Université Catholique de Louvain = Catholic University of Louvain (UCL), Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), NanoBioInterfaces - IEMN (NBI - IEMN), Institut d’Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520 (IEMN), Ecole Centrale de Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Laboratoire International associé sur les phénomènes Critiques et Supercritiques en électronique fonctionnelle, acoustique et fluidique (LIA LICS/LEMAC), Ecole Centrale de Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Ecole Centrale de Lille-Université de Lille-Université Polytechnique Hauts-de-France (UPHF)-Université Polytechnique Hauts-de-France (UPHF), UCL - SST/ICTM/ELEN - Pôle en ingénierie électrique, University of São Paulo (USP), Physique-IEMN (PHYSIQUE-IEMN), Centrale Lille Institut (CLIL)-Université d'Artois (UA)-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Lille, and Institute of Chemistry, University of São Paulo
Subjects: Materials science, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, Electrochemistry, 01 natural sciences, 7. Clean energy, Catalysis, [CHIM]Chemical Sciences, General Materials Science, Irradiation, Plasmon, ComputingMilieux_MISCELLANEOUS, Power density, Renewable Energy, Sustainability and the Environment, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.CATA]Chemical Sciences/Catalysis, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Wavelength, chemistry, Chemical engineering, Electrode, 0210 nano-technology, Platinum
Abstract: Plasmon-driven chemical transformation has become a promising approach for enhancing sluggish electrocatalytic reactions. Herein, an alternative enhancement strategy employing plasmon-induced hot electrons was developed and found to be competitive with oxygen reduction reaction (ORR) on platinum electrodes. We demonstrated that, by using the intertwined plasmon-catalytic-electrochemical properties of nanoperforated gold thin film electrodes, the ORR under alkaline conditions could be significantly enhanced by careful tuning of the laser wavelength and power density. Irradiation at 980 nm and 2 W cm−2 displays maximal current densities of j = −6.0 A cm−2 at 0.95 V vs. RHE, under hydrodynamic conditions, comparable to that of commercial Pt/C (40 wt%) catalysts, with good long-term stability. The wavelength-dependent electrochemical reduction confirmed that the hot carriers formed during plasmon decay are responsible for the improved electrocatalytic performance. 8;20
Published: 2020

46. Ark: a constraint-based method for architectural synthesis of smart systems

Author: Elisa Yumi Nakagawa, Milena Guessi, Flavio Oquendo, Universidade de São Paulo = University of São Paulo (USP), Advanced Technologies for Operated Networks (ARCHWARE), LANGAGE ET GÉNIE LOGICIEL (IRISA-D4), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Université de Bretagne Sud (UBS), Instituto de Ciências Mathemàticas e de Computação [São Carlos] (ICMC-USP), University of São Paulo (USP), Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National de Recherche en Informatique et en Automatique (Inria)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-CentraleSupélec-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Universidade de São Paulo (USP)
Subjects: ESTUDO DE CASO, Smart system, Correctness, Bridging (networking), Computer science, business.industry, Abstract and concrete, 020207 software engineering, 02 engineering and technology, [INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE], Formal methods, Software, Modeling and Simulation, 0202 electrical engineering, electronic engineering, information engineering, [INFO]Computer Science [cs], Architecture, Software architecture, Software engineering, business, ComputingMilieux_MISCELLANEOUS
Abstract: As smart systems leverage capabilities of heterogeneous systems for accomplishing complex combined behaviors, they pose new challenges to traditional software engineering practices that considered software architectures to be mostly static and stable. The software architecture of a smart system is inherently dynamic due to uncertainty surrounding its operational environment. While the abstract architecture offers a way to implicitly describe different forms taken by the software architecture at run time, it is still not sufficient to guarantee that all concrete architectures will automatically adhere to it. To address this issue, this work presents a formal method named Ark supporting the architectural synthesis of smart systems. This is achieved by expressing abstract architectures as a set of constraints that must be valid for any concrete architecture of the smart system. This way, we can benefit from existing model-checking techniques to guarantee that all concrete architectures realized from such an abstract model will comply with well-formed rules. We also describe how this method can be incorporated to a model-driven approach for bridging the gap between abstract and concrete architectural models. We demonstrate our method in an illustrative case study, showing how Ark can be used to support the synthesis of concrete architectures as well check the correctness and completeness of abstract architecture descriptions. Finally, we elaborate on future directions to consolidating a process for the synthesis of run-rime architectures that are correct-by-construction.
Published: 2020

47. Efficient Oxidative Esterification of Furfural Using Au Nanoparticles Supported on Group 2 Alkaline Earth Metal Oxides

Author: Mariusz Pietrowski, Ivaldo Itabaiana, Adriano H. Braga, Franck Dumeignil, Camila P. Ferraz, Mohamed Nawfal Ghazzal, Liane M. Rossi, Michał Zieliński, Robert Wojcieszak, Institute of Chemistry, University of São Paulo, University of São Paulo (USP), Laboratoire de Chimie Physique D'Orsay (LCPO), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Unité de Catalyse et de Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Ecole Centrale de Lille-Ecole Nationale Supérieure de Chimie de Lille (ENSCL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Université de Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181, Institute of Chemistry, Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS], Laboratoire de Chimie Physique D'Orsay [LCPO], São Paulo State University, Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie Physique (ICP), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Adam Mickiewicz University in Poznań (UAM), Universidade de São Paulo = University of São Paulo (USP), Centrale Lille Institut (CLIL)-Université d'Artois (UA)-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Lille, and Universidade de São Paulo (USP)
Subjects: esterification, Alcohol, 010402 general chemistry, Furfural, lcsh:Chemical technology, 01 natural sciences, 7. Clean energy, Catalysis, Reaction rate, lcsh:Chemistry, chemistry.chemical_compound, Organic chemistry, [CHIM]Chemical Sciences, lcsh:TP1-1185, Physical and Theoretical Chemistry, OURO, Alkyl, ComputingMilieux_MISCELLANEOUS, chemistry.chemical_classification, integumentary system, biomass, 010405 organic chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, green oxidation, Acetal, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, 0104 chemical sciences, 3. Good health, chemistry, lcsh:QD1-999, Yield (chemistry), gold nanoparticles, Selectivity, methyl furoate
Abstract: Furfural (FF) is a strategic product for the development of highly valued chemicals from biomass. The oxidation product of FF, furoic acid (FA), is an important precursor for the synthesis of green esters, such as methyl furoate. Taking into account issues with the direct furfural oxidation, furfural derivatives, such as alkyl furoates, can be easily prepared via oxidative esterification. Here, Au nanoparticles that were immobilized on alkaline-earth metal oxide supports were studied for the oxidative esterification of furfural while using alcohol as both reactant and solvent. The formation of esters is favored by the presence of basic sites on catalyst surface, resulting in high selectivity, preventing the formation of the acetal as a by-product. The Au/MgO sample provided up to 95% methyl furoate (MF) yield, a fast reaction rate, and high performance for furfural:Au molar ratios between 50 and 300. Furthermore, this catalyst was stable during reuse, since both the selectivity and the activity were maintained after four cycles. Oxidative esterification products were achieved in the presence of other alcohols, leading to the formation of esters of up to C5 (isopentyl furoate) with high selectivity (&gt, 99%). Linear and branched esters were formed, but the long-chain linear alcohols resulted in higher yields, such as n-butyl furoate in 94% yield.
Published: 2020

48. Characterization of post-edited cells modified in the TFAM gene by CRISPR/Cas9 technology in the bovine model

Author: Vanessa Cristina de Oliveira, Paulo Fantinato-Neto, Jean-Paul Concordet, Flávio Vieira Meirelles, Clésio Gomes Mariano Junior, José Ernesto Belizário, Fabiana Fernandes Bressan, Marcos Roberto Chiaratti, José Eduardo Krieger, Carlos Eduardo Ambrósio, Kelly Cristine Santos Roballo, University of São Paulo (USP), University of Wyoming (UW), Federal University of São Carlos (UFSCar), Structure et Instabilité des Génomes (STRING), Muséum national d'Histoire naturelle (MNHN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sao Paulo Research Foundation FAPESP-grant #2017/08896-4 to VCO website: http://fapesp.br/ USP/COFECUB Agreement #2013.1.3010.1.0 to JEB website:http://www.usp.br/internationaloffice/index.php/programas-eredes/programas/programa-usp-cofecub, Bodescot, Myriam, and Universidade de São Paulo = University of São Paulo (USP)
Subjects: 0301 basic medicine, Physiology, Cell, Gene Dosage, Gene Expression, Mitochondrion, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Biochemistry, 0302 clinical medicine, Animal Cells, Medicine and Health Sciences, Inner mitochondrial membrane, Cells, Cultured, Energy-Producing Organelles, Connective Tissue Cells, Gene Editing, Multidisciplinary, Mitochondrial DNA, 3. Good health, Cell biology, Mitochondria, Nucleic acids, Electrophysiology, medicine.anatomical_structure, Connective Tissue, Medicine, Cellular Structures and Organelles, Cellular Types, Anatomy, Research Article, DNA Replication, Forms of DNA, Imaging Techniques, Science, [SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Bioenergetics, Research and Analysis Methods, Gene dosage, DNA, Mitochondrial, Membrane Potential, Mitochondrial Proteins, 03 medical and health sciences, DNA-binding proteins, Fluorescence Imaging, medicine, Genetics, Animals, Gene Regulation, Molecular Biology Techniques, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Gene, Molecular Biology, Biology and life sciences, Proteins, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, DNA, Cell Biology, TFAM, Fibroblasts, Regulatory Proteins, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, 030104 developmental biology, Biological Tissue, Cell culture, Cattle, Mitochondrial Membrane, CRISPR-Cas Systems, 030217 neurology & neurosurgery, Transcription Factors, Cloning
Abstract: International audience; Gene editing in large animal models for future applications in translational medicine and food production must be deeply investigated for an increase of knowledge. The mitochondrial transcription factor A (TFAM) is a member of the HMGB subfamily that binds to mtDNA promoters. This gene maintains mtDNA, and it is essential for the initiation of mtDNA transcription. Lately, we generated a new cell line through the disruption of the TFAM gene in bovine fibroblast cells by CRISPR/Cas 9 technology. We showed that the CRISPR/Cas9 design was efficient through the generation of heterozygous mutant clones. In this context, once this gene regulates the mtDNA replication specificity, the study aimed to determine if the post-edited cells are capable of in vitro maintenance and assess if they present changes in mtDNA copies and mitochondrial membrane potential after successive passages in culture. The post-edited cells were expanded in culture, and we performed a growth curve, doubling time, cell viability, mitochondrial DNA copy number, and mitochondrial membrane potential assays. The editing process did not make cell culture unfeasible, even though cell growth rate and viability were decreased compared to control since we observed the cells grow well when cultured in a medium supplemented with uridine and pyruvate. They also exhibited a classical fibroblastoid appearance. The RT-qPCR to determine the mtDNA copy number showed a decrease in the edited clones compared to the non-edited ones (control) in different cell passages. Cell staining with Mitotracker Green and red suggests a reduction in red fluorescence in the edited cells compared to the non-edited cells. Thus, through characterization, we demonstrated that the TFAM gene is critical to mitochondrial maintenance due to its interference in the stability of the mitochondrial DNA copy number in different cell passages and membrane potential confirming the decrease in mitochondrial activity in cells edited in heterozygosis.
Published: 2020

49. Vegetation and fire variability in the central Cerrados (Brazil) during the Pleistocene-Holocene transition was influenced by oscillations in the SASM boundary belt

Author: Charly Favier, Marie-Pierre Ledru, Rudney de Almeida Santos, Raquel Franco Cassino, Departamento de Geologia, Universidade Federal de Ouro Preto (UFOP), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226, University of São Paulo (USP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), and Universidade de São Paulo = University of São Paulo (USP)
Subjects: 010506 paleontology, Archeology, 010504 meteorology & atmospheric sciences, Pleistocene, [SDE.MCG]Environmental Sciences/Global Changes, Monsoon, 01 natural sciences, Tropical savanna climate, Paleoclimatology, Younger Dryas, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, Ecology, Evolution, Behavior and Systematics, Holocene, 0105 earth and related environmental sciences, Termination 1, Global and Planetary Change, Fire regime, Geology, Vegetation, 15. Life on land, tropical savanna, 13. Climate action, pollen, Physical geography, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Brazil, fire
Abstract: International audience; This study investigates historical fire regimes and arboreal cover variability in the Brazilian Cerrados, a large Neotropical savanna ecosystem, during the Pleistocene-Holocene transition and early Holocene, and then tests whether the observed variation is linked to South American Summer Monsoon (SASM) variability. We present high-resolution pollen, XRF and charcoal records from lake Lagoa Feia, located in central Cerrados, and assess how they compare with other pollen records from the surrounding region to investigate regional trends of vegetation and fire regime variability. Our results show that the Pleistocene-Holocene transition was marked by a wet episode, which included moist forest expansion and rising lake levels, that correlates well with increased monsoon activity in a large area of central South America during the same period. This wet episode chronologically coincides with the Younger Dryas cold episode in the northern hemisphere. Our data revealed moisture declines in central Cerrados after 11.2 kyr BP, along with centennial-scale fluctuations from dry to wet conditions throughout the early Holocene period until around 6 kyr BP. These dry/wet oscillations are associated with weakened SASM activity and repeated shifts of its belt position during this time range. Fire activity increased in central Cerrados just after the onset of drier conditions during the early Holocene, and likely contributed to decreased arboreal cover at that time. A trend of increasing moisture in the region was observed after 6 kyr BP. Our study reveals how centennial and millennial-scale changes in monsoon activity influenced arboreal cover, diversity and fire regimes in the central Cerrados.
Published: 2020

50. The Forest Effects on the Isotopic Composition of Rainfall in the Northwestern Amazon Basin

Author: Renato Campello Cordeiro, Jhan Carlo Espinoza, Angela Ampuero, Valdir F. Novello, Nicola M. Stríkis, Francisco W. Cruz, Hubert B. Vonhof, James Apaéstegui, Victor C. Mayta, Mathias Vuille, Abdelfettah Sifeddine, V. Azevedo, Veridiana Teixeira de Souza Martins, Universidade Federal Fluminense [Rio de Janeiro] (UFF), Instituto Geofísico del Perú (IGP), Department of Atmospheric and Environmental Sciences [Albany] (DAES), University at Albany [SUNY], State University of New York (SUNY)-State University of New York (SUNY), Instituto de Geociências [São Paulo], Universidade de São Paulo = University of São Paulo (USP), Institut des Géosciences de l’Environnement (IGE), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Max Planck Institute for Chemistry (MPIC), Max-Planck-Gesellschaft, Departamento de Ciencias Atmosfericas [São Paulo], Instituto de Astronomia, Geofísica e Ciências Atmosféricas [São Paulo] (IAG), Universidade de São Paulo = University of São Paulo (USP)-Universidade de São Paulo = University of São Paulo (USP), Variabilité à long terme du climat de l'océan (VALCO), Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques (LOCEAN), Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), ANR-18-MPGA-0008,AMANECER,Connexion Amazone - Andes(2018), Universidade de São Paulo (USP), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Universidade de São Paulo (USP)-Universidade de São Paulo (USP), Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Institut de Recherche pour le Développement (IRD)-Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Institut de Recherche pour le Développement (IRD)-Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)
Subjects: Atmospheric Science, geography, geography.geographical_feature_category, 010504 meteorology & atmospheric sciences, Amazon rainforest, Speleothem, [PHYS.PHYS.PHYS-GEO-PH]Physics [physics]/Physics [physics]/Geophysics [physics.geo-ph], 15. Life on land, 010502 geochemistry & geophysics, 01 natural sciences, Isotopic composition, DEUTÉRIO, Geophysics, 13. Climate action, Space and Planetary Science, Earth and Planetary Sciences (miscellaneous), Environmental science, Precipitation, Physical geography, Holocene, 0105 earth and related environmental sciences, Amazon basin
Abstract: International audience; In the Amazon basin, intense precipitation recycling across the forest significantly modifies the isotopic composition of rainfall (δ18O, δD). In the tropical hydrologic cycle, such an effect can be identified through deuterium excess (dxs), yet it remains unclear what environmental factors control dxs, increasing the uncertainty of dxs‐based paleoclimate reconstructions. Here we present a 4‐year record of the isotopic composition of rainfall, monitored in the northwestern Amazon basin. We analyze the isotopic variations as a function of the air mass history, based on atmospheric back trajectory analyses, satellite observations of precipitation upstream, leaf area index, and simulated moisture recycling along the transport pathway. We show that the precipitation recycling in the forest exerts a significant control on the isotopic composition of precipitation in the northwestern Amazon basin, especially on dxs during the dry season (r = 0.71). Applying these observations to existing speleothem and pollen paleorecords, we conclude that winter precipitation increased after the mid‐Holocene, as the expansion of the forest allowed for more moisture recycling. Therefore, forest effects should be considered when interpreting paleorecords of past precipitation changes.
Published: 2020

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