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The article explores two new initiatives launched in 2024 in France, aimed at exploring the potential of artificial intelligence to support or enhance democratic processes amidst growing concerns over its impact on politics. It states that the "Democratic Commons" project, a collaboration between Make.org, Sorbonne Université, and CNRS, focuses on researching AI's role in strengthening democratic foundations in a world facing unprecedented institutional trust crises and information warfare.

An interview with Jean-Luc Marion, professor emeritus of philosophy at the Sorbonne and retired professor of Catholic studies, the philosophy of religions and theology at the University of Chicago, is presented. He discusses his experience working with scholars and great French theologians at a young age, his double courses at the Sorbonne, and his extraordinary experience while walking in the Luxembourg gardens in Paris, France.

The article from the University of Paris explores the potential of non-nucleoside inhibitors targeting DNMT1 and DNMT3 in cancer therapy. Topics discussed include the role of DNA methylation in cancer, the advantages of non-nucleoside inhibitors over nucleoside analogues, and potential new targets and compounds for selective inhibition.

The article reports on a study from the University of Paris investigating anxiety disorders and spontaneous learning in social contexts among individuals with Autism Spectrum Condition (ASC). Topics include the impact of autism severity on learning to approach happy individuals, the relationship between anxiety-depression severity and learning outcomes, and the comparison of learning abilities between individuals with ASC and typically developing (TD) individuals.

A study conducted by the University of Paris Saclay examined the oral health of ultraendurance trail runners. Despite the increased risk of cavities due to the consumption of sugary substances during long-distance exercise and a lack of oral hygiene during races, the runners had good oral health. The researchers found that the runners' compliance with preventive oral health recommendations, such as regular toothbrushing and dental visits, may counterbalance the risks associated with their exposure to caries. The study suggests that developing targeted primary prevention strategies accessible at race venues could be more effective than individual prevention strategies implemented at dental offices. [Extracted from the article]

A recent study conducted by the University of Paris has identified four distinct subgroups of patients with Antiphospholipid Syndrome (APS), a heterogeneous autoimmune disease. The study used an unsupervised hierarchical cluster analysis to classify 509 APS patients based on various clinical and laboratory manifestations. The four subgroups were characterized by different clinical features, including venous thromboembolism, arterial events, associated systemic lupus erythematosus (SLE) or other autoimmune diseases, and catastrophic APS. The findings suggest that APS has diverse pathophysiological mechanisms. [Extracted from the article]

A recent study conducted by researchers from the University of Paris focused on bone and joint infections (BJI) in children with sickle cell disease (SCD) in French Guiana. The study aimed to describe the epidemiology of BJI in this population. The researchers found that BJI in children with SCD is not sufficiently microbiologically documented, and improvements need to be made in this area. The study provides valuable insights into the challenges of diagnosing and treating BJI in children with SCD in French Guiana. [Extracted from the article]

A recent report from the University of Paris explores the use of pickering emulsions as a potential treatment for psoriasis, an inflammatory skin disease. The emulsions, which contain nanoparticles loaded with immunosuppressive drugs, were found to inhibit the production of proinflammatory cytokines and reduce the expression of T-cell markers in both lymphocytes and keratinocytes. In an imiquimod-induced psoriasis-like mouse model, the emulsions significantly alleviated psoriasiform lesions. This research suggests that pickering emulsions could be an effective formulation for treating inflammatory dermatoses. [Extracted from the article]

A recent study conducted by the University of Paris aimed to develop a French version of the Child Perceptions Questionnaire for children aged 11 to 14 years old (CPQ11-14). The researchers used a forward-backward translation process and pretested the questionnaire on 187 children. The study found that the French version of CPQ11-14 was reliable and valid in assessing the impact of oral health on children's quality of life. This questionnaire can be used alongside the CPQ8-10 and the parental version to comprehensively evaluate children's oral health. [Extracted from the article]

A recent study conducted by researchers from the University of Paris explores the potential of virtual reality (VR) in the treatment of alcohol use disorder (AUD). The study aims to compare the effectiveness of a treatment strategy combining VR cue exposure therapy (VR-CET) and cognitive behavioral therapy (CBT) with conventional CBT in reducing alcohol consumption and cravings in patients with AUD. The study will also examine the effects of VR-CET combined with CBT on anxiety, depression, rumination, and feelings of self-efficacy. The trial will be conducted over 8 months in four addiction departments in France and will involve 156 patients diagnosed with AUD. The primary outcome will be the cumulative number of standard drinks consumed at 8 months. The researchers hope that this study will contribute to the existing literature on the use of VR in the treatment of AUD and provide new perspectives for future interventions. [Extracted from the article]

A recent study conducted by the University of Paris highlights the need for standardized data collection in adjuvant colon cancer trials. The researchers emphasize the importance of refining risk assessment and establishing optimal treatment strategies in the adjuvant setting. The study involved a consensus project with experts in the field, resulting in the identification of 28 variables that should be uniformly reported in future clinical trials for adjuvant colon cancer. This research provides valuable insights for researchers and clinicians working in the field of colon cancer treatment. [Extracted from the article]

A recent study conducted at the University of Paris explored the role of rehabilitation medicine in improving the quality of life for patients with severe obesity. The study included 124 patients who participated in an 8-week in-hospital program that combined physiotherapy, nutrition, and psychological support. The results showed a significant improvement in the patients' quality of life scores, which were positively correlated with cardio-respiratory function. The researchers concluded that multidisciplinary rehabilitation medicine plays an important role in enhancing the quality of life for individuals with obesity. [Extracted from the article]

A recent report from the University of Paris Saclay discusses the use of mathematical modeling and hierarchical inference to determine the minimal dose of IFNa therapy for Myeloproliferative Neoplasms (MPN). MPN are blood cancers that occur after acquiring a driver mutation in a hematopoietic stem cell. The study found that IFNa therapy can induce long-term remission when a sufficient dose is reached, and they determined the minimal dose for individuals in a patient cohort. This research provides valuable insights into optimizing the treatment of MPN and increasing the chances of a cure. [Extracted from the article]

A study conducted by researchers at the University of Paris examined the sources and factors of resilience in Russian sexual and gender minorities. The study found that LGBT individuals who were involved in their community reported more social support from friends, which partially mediated the positive association between community involvement and mental health. The study emphasizes the importance of the LGBT community in providing support during times of increasing stigmatization. The research was published in the European Journal of Psychology Open. [Extracted from the article]

A study conducted by the University of Paris aimed to understand the impact of extreme temperatures on mental health. The researchers analyzed emergency visits for psychiatric disorders in French hospitals during heatwaves. They found that there was an increased risk of dementia and psychoses on days with extreme temperatures, while mood disorders showed a decreased risk. The study highlights the importance of considering mental health management during future heatwaves. This research has been peer-reviewed and published in The European Journal of Psychiatry. [Extracted from the article]

A report from the University of Paris discusses the development of new anticoagulants to prevent thrombosis, which remains one of the leading causes of death worldwide. The report highlights the evolution of anticoagulation treatments from non-specific drugs to agents that directly target specific coagulation factors. While direct oral anticoagulants (DOACs) have been widely used due to their ease of use and favorable pharmacological profile, they still carry a bleeding risk. The report focuses on the potential of new anticoagulants that target the contact phase of coagulation, specifically FXI/FXIa inhibition, and discusses the challenges that this new therapeutic class may face. [Extracted from the article]

A study conducted by the University of Paris examined the effectiveness of different maintenance therapies for individuals with unresectable or metastatic colorectal cancer (mCRC). The study compared olaparib with or without bevacizumab to bevacizumab plus a fluoropyrimidine. The primary endpoint was progression-free survival (PFS), and the study found that neither olaparib alone nor olaparib with bevacizumab demonstrated clinical efficacy compared to bevacizumab plus a fluoropyrimidine. The study was stopped prematurely due to meeting criteria for futility. This research provides valuable insights into potential treatment options for advanced colorectal cancer. [Extracted from the article]

"The Elements of Marie Curie: How the Glow of Radium Lit a Path for Women in Science" by Dava Sobel is a nonfiction book that explores Marie Curie's impact on women in science. Sobel examines how Curie kick-started the careers of many women scientists at her University of Paris laboratory, including Ellen Gleditsch and Marguerite Perey. However, the book falls short in providing a comprehensive discussion of Curie's working relationships with her assistants, which makes each scientist's chapter feel disconnected. Sobel also highlights the sexism women scientists faced during that time, but Curie's role in their lives remains unclear. [Extracted from the article]

Researchers from the University of Paris Saclay have conducted a study on cervical cancer, specifically focusing on automatic gross tumor volume (GTV) segmentation and failure detection. The study compared different deep learning models for GTV segmentation and introduced a novel method for failure detection using radiomic features. The researchers found that 2D networks outperformed 3D networks in 2D MRI sequences, saving time for doctors. The proposed failure detection method could guide doctors in sensitive cases. [Extracted from the article]

A recent study conducted by researchers at the University of Paris explores the role of plakins in the regulation of centrosome position in polarized epithelial cells. The researchers found that low levels of epiplakin, desmoplakin, and periplakin were associated with centrosome mispositioning in cells that had undergone the epithelial-to-mesenchymal transition (EMT) or tissue transformation. The downregulation of these plakins disrupted centrosome polarization towards intercellular junctions without affecting microtubule stability. These findings suggest that the downregulation of plakins and subsequent centrosome mispositioning are key factors in the disorganization of cytoskeleton networks, weakening of intercellular junctions, and loss of polarity in breast cancer cells. This research provides potential new markers for early stages of tumor development. [Extracted from the article]

A study conducted at the University of Paris examined the progesterone levels in women with endometriosis who achieved a live birth after hormone replacement therapy-frozen embryo transfer (HRT-FET). The researchers found that the progesterone levels on the day of transfer did not differ between women with endometriosis and unaffected women. The study included 1784 patients, and subgroup analyses were performed based on the presence of deep infiltrating endometriosis or adenomyosis. The findings suggest that patients diagnosed with endometriosis do not require higher progesterone levels to achieve a live birth in HRT cycles. [Extracted from the article]

A research study conducted by the University of Paris aims to evaluate the addition of darolutamide to androgen deprivation therapy (ADT) and radiation therapy (RT) in newly diagnosed prostate cancer patients with pelvic lymph node metastases. The study, called ALADDIN, will enroll approximately 152 patients who are treatment-naive for hormonal therapy and have positive lymph node disease. The primary endpoint of the study is failure-free survival, and secondary endpoints include overall survival, progression-free survival, safety, and health-related quality of life. The study is expected to last for 7 years, with accrual lasting for 2 years. [Extracted from the article]

A study conducted by researchers at the University of Paris Saclay explores the influence of microbiota on behavior and serotonin metabolism in germ-free mice. The study found that germ-free mice exhibited decreased locomotor activity and signs of increased anxiety-like behavior compared to conventional mice. While no impact on brain serotonin levels was observed, there were significant differences in gut serotonin metabolism, indicating a varying role of microbiota along the gastrointestinal tract. The findings suggest that the microbiota plays a role in regulating behavior, although genetic and environmental factors also have an impact. [Extracted from the article]

A recent study conducted by researchers at the University of Paris explored the relationship between skin microbiota and acne vulgaris. The study found that an imbalance in skin microbiota can lead to the development or worsening of chronic inflammatory acne lesions. Specifically, the presence of certain ribotypes of Cutibacterium acnes (C. acnes) was associated with inflammatory acne lesions, while another ribotype was found to be beneficial for the skin. The researchers conducted a clinical trial involving 32 adult acne patients who applied a topical emulsion containing a vegetal extract and a polysaccharide. They observed a significant improvement in acne lesions and a corresponding improvement in the skin microbiome. This research provides valuable insights into the potential role of microbiota modulation in the treatment of acne vulgaris. [Extracted from the article]

A recent study conducted by researchers from the University of Paris examines the factors that influence support for the Black Lives Matter (BLM) movement. The study argues that national contexts and their peculiarities play a significant role in shaping BLM support. In a French ecological context, where national identity is based on a limited view of diversity and diversity issues are regulated by two opposing cultural norms, the study found that national identification negatively predicts BLM support. The study suggests that these findings have broader implications for understanding how both intra- and inter-national forces shape responses to diversity. [Extracted from the article]

A study conducted by researchers at the University of Paris has developed a software called PitViper, which aims to integrate and analyze functional genomics screening data. The software is designed to fill a gap in the field by providing a cohesive framework for comprehensive data integration. The researchers found that PitViper is a useful tool for identifying potential super-enhancer liabilities in a leukemia cell line through genome-wide CRISPRi-based screening. This software offers a robust, flexible, and interactive solution for researchers in the field of genomics and bioinformatics. [Extracted from the article]

A recent study conducted at the University of Paris aimed to determine the proportion of individuals with inappropriate arterial stiffness measured by pulse wave velocity (PWV) and blood pressure (BP) levels, as well as the associated characteristics. The study utilized data from 5,186 participants and found that younger age, higher body mass index (BMI), and the presence of diabetes mellitus (DM) were associated with inappropriately high PWV. The researchers concluded that screening younger patients for inappropriate arterial stiffness, regardless of their BP levels, could lead to early detection of organ damage and targeted preventive strategies. The full study can be accessed in the Journal of Hypertension. [Extracted from the article]

A study conducted at the University of Paris aimed to evaluate the impact of elexacaftor-tezacaftor-ivacaftor (ETI) on lung structural abnormalities in adults with cystic fibrosis (awCF), specifically focusing on the reversal of bronchial dilatations. The study found that 5% of awCF treated with ETI experienced a reversal of bronchial dilatations. The reversal was limited to cylindrical bronchial dilatations and occurred in a small subset of awCF. The research suggests that initiating ETI earlier in life may lead to the reversal of early bronchial dilatations. [Extracted from the article]

A study conducted by researchers at the University of Paris explores the experiences of fathers during the first few months after their child's birth and the links between perceived social support, sense of parental efficacy, and postpartum depression. The study involved 376 fathers in France who completed measures of depression symptoms, perceived social support, and sense of parental efficacy. The findings revealed that fathers with lower levels of perceived social support and sense of parental efficacy reported higher levels of postpartum depression symptoms. The study emphasizes the importance of providing tailored support to fathers during the transition to parenthood to promote their mental health and well-being. [Extracted from the article]

A recent study conducted by researchers at the University of Paris I explores the factors influencing vaccine hesitancy during an epidemic. The study found that vaccination rates among the elderly can influence vaccination rates among young adults. The researchers propose an epidemiological economic model that considers the opinions of "vaxxers" and "antivaxxers" in different age groups. The study suggests that leveraging the vaccination behavior of the elderly can help promote vaccination. This research has been peer-reviewed and provides valuable insights into the dynamics of vaccination during an epidemic. [Extracted from the article]

A recent study conducted at the University of Paris examined the use of obinutuzumab in children with autoimmune encephalitis and early B-cell repopulation on rituximab. The study included eight children who were treated with obinutuzumab, and the results showed that obinutuzumab had a better biological efficacy than rituximab, with a longer time of B-cell repopulation. The dosage regimen for obinutuzumab was one infusion of 1000 mg/1.73 m, and none of the patients experienced side effects. The study suggests that obinutuzumab may be a safe and effective treatment option for pediatric patients with neurological inflammatory diseases. [Extracted from the article]

A new report from the University of Paris presents data on the treatment patterns and clinical outcomes of patients with moderate to severe acute graft-versus-host disease (aGVHD) after hematopoietic stem cell transplantation (HSCT). The study included 151 patients from Finland, Sweden, and France, with a median age of 56 years. Methylprednisolone was the most common first-line treatment, and 79.5% of patients treated with methylprednisolone achieved a complete or partial response. The study found that chronic GVHD occurred in 37.7% of patients, and mortality rates at 6 and 12 months were 30.0% and 37.3%, respectively. The researchers concluded that there is a need for new therapies to control aGVHD and improve mortality rates. [Extracted from the article]