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110,068 results on '"Université Claude Bernard Lyon 1 ( UCBL )"'

1. Prismatic Adaptation for Rehabilitation of Postural Imbalance After Stroke (PEQUIE)

Author: Centre National de la Recherche Scientifique, France, Institut National de la Santé Et de la Recherche Médicale, France, Université Claude Bernard Lyon 1 (UCBL), and Equipe " ImpAct Trajectoires " du Centre de Recherche en Neurosciences de Lyon (CRNL)
Published: 2022

2. Floating-point arithmetic

Author: Sylvie Boldo, Claude-Pierre Jeannerod, Guillaume Melquiond, Jean-Michel Muller, Formally Verified Programs, Certified Tools and Numerical Computations (TOCCATA), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Méthodes Formelles (LMF), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay), Arithmétiques des ordinateurs, méthodes formelles, génération de code (ARIC), Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Lyon, Institut National de Recherche en Informatique et en Automatique (Inria), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), ANR-20-CE48-0014,NuSCAP,Sûreté numérique pour les preuves assistées par ordinateur(2020), and European Project: 810367,EMC2(2019)
Subjects: computer arithmetic, Numerical Analysis, [INFO.INFO-AO]Computer Science [cs]/Computer Arithmetic, General Mathematics, Floating-point arithmetic, numerical computing
Abstract: Floating-point numbers have an intuitive meaning when it comes to physics-based numerical computations, and they have thus become the most common way of approximating real numbers in computers. The IEEE-754 Standard has played a large part in making floating-point arithmetic ubiquitous today, by specifying its semantics in a strict yet useful way as early as 1985. In particular, floating-point operations should be performed as if their results were first computed with an infinite precision and then rounded to the target format. A consequence is that floating-point arithmetic satisfies the ‘standard model’ that is often used for analysing the accuracy of floating-point algorithms. But that is only scraping the surface, and floating-point arithmetic offers much more.In this survey we recall the history of floating-point arithmetic as well as its specification mandated by the IEEE-754 Standard. We also recall what properties it entails and what every programmer should know when designing a floating-point algorithm. We provide various basic blocks that can be implemented with floating-point arithmetic. In particular, one can actually compute the rounding error caused by some floating-point operations, which paves the way to designing more accurate algorithms. More generally, properties of floating-point arithmetic make it possible to extend the accuracy of computations beyond working precision.
Published: 2023

3. Cuticle architecture and mechanical properties: a functional relationship delineated through correlated multimodal imaging

Author: Nicolas Reynoud, Nathalie Geneix, Angelina D’Orlando, Johann Petit, Jeremie Mathurin, Ariane Deniset-Besseau, Didier Marion, Christophe Rothan, Marc Lahaye, Bénédicte Bakan, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), BioInformatique et BioStatistiques (BIBS), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Biologie du fruit et pathologie (BFP), Université de Bordeaux (UB)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Chimie Physique (ICP), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), INRAE and Region Pays de la Loire (Fr)., and ANR-21-CE11-0035,COPLAnAR,COPLAnAR : cartography corrélative pour élucider les relations structure-propriétés de la cuticule des plantes(2021)
Subjects: hyperspectral, plant cuticle, Solanum lycopersicum, Physiology, nanomechanical, AFM PF-QNM, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, correlated multimodal imaging, Plant Science, Raman
Abstract: Cuticle are multifunctional hydrophobic biocomposites that protect aerial organs of plants. Along plant development, plant cuticle must accommodate different mechanical constraints combining extensibility and stiffness, the corresponding structure-function relationships are unknown. Recent data showed a fine architectural tuning of the cuticle architecture and the corresponding chemical clusters along fruit development which raise the question of their impact on the mechanical properties of the cuticle.We investigated the in-depth nanomechanical properties of tomato fruit cuticle from early development to ripening, in relation to chemical and structural heterogeneities by developing a correlative multimodal imaging approach.Unprecedented sharps heterogeneities were evidenced with the highlighting of an in-depth mechanical gradient and a ‘soft’ central furrow that were maintained throughout the plant development despite the overall increase in elastic modulus. In addition, we demonstrated that these local mechanical areas are correlated to chemical and structural gradients.This study shed light on a fine tuning of mechanical properties of cuticle through the modulation of their architecture, providing new insight for our understanding of structure-function relationships of plant cuticle and for the design of biosinpired material.
Published: 2023

4. Biotic and abiotic drivers of aquatic plant communities in shallow pools and wallows on the sub-Antarctic Iles Kerguelen

Author: Douce, Pauline, Mermillod‐blondin, Florian, Simon, Laurent, Dolédec, Sylvain, Eymar‐dauphin, Pauline, Renault, David, Sulmon, Cécile, Vallier, Félix, Bittebiere, Anne-Kristel, Équipe 1 - Biodiversité et Adaptation dans les Hydrosystèmes (BAH), Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés (LEHNA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS), Équipe 3 - Écologie, Évolution, Écosystemes Souterrains (E3S), Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), and Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Habitat, Plant community structure, Spatio-temporal variability, Seasonality, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, Aquatic plants, Ponds, General Agricultural and Biological Sciences
Abstract: International audience; In the sub-Antarctic region, climate change is particularly rapid, while their freshwater ecosystems, such as ponds, host plant species with limited spatial distributions. These particular systems and their plant communities remain however poorly known and the context of their changing habitat calls for deeper insights into these systems. We performed an extensive survey of 45 ponds over three locations of the Iles Kerguelen during the winter and summer seasons of two years, which included the measurement of 12 abiotic parameters and the assessment of the plant community composition. Overall, our results showed that Iles Kerguelen ponds are shallow freshwater ecosystems harbouring species-poor plant communities with high even- ness, of which structure did not vary among the sampled locations. Three different habitats were identified among ponds in relation with nutrient supply by marine animals, which ultimately influenced plant community structure and cover. We highlight that these habitats are mostly determined by water depth, nutrients, and temperature (mean and variance). Present plant community composition was more strongly correlated with plant community composition in the previous year than with abiotic conditions. Overall, this study provides new knowledge on the aquatic plant communities and the functioning of Iles Kerguelen freshwater ecosystems, which can serve as a basis for future studies dealing with the impact of climate change in the sub-Antarctic region.
Published: 2023

5. Rapid protection induced by a single-shot Lassa vaccine in male cynomolgus monkeys

Author: Mathieu Mateo, Stéphanie Reynard, Natalia Pietrosemoli, Emeline Perthame, Alexandra Journeaux, Kodie Noy, Clara Germain, Xavier Carnec, Caroline Picard, Virginie Borges-Cardoso, Jimmy Hortion, Hélène Lopez-Maestre, Pierrick Regnard, Lyne Fellmann, Audrey Vallve, Stéphane Barron, Ophélie Jourjon, Orianne Lacroix, Aurélie Duthey, Manon Dirheimer, Maïlys Daniau, Catherine Legras-Lachuer, Caroline Carbonnelle, Hervé Raoul, Frédéric Tangy, Sylvain Baize, Biologie des Infections Virales Émergentes - Biology of Emerging Viral Infections (UBIVE), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Université de Strasbourg (UNISTRA), Simian Laboratory Europe (SILABE), Laboratoire P4 Jean Mérieux-Inserm [Lyon] (Unité de service 3), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Européen de Recherche en Virologie et Immunologie [Lyon] (Tour Inserm CERVI), Délégation régionale Auvergne Rhône-Alpes [Bron, France], Institut National de la Santé et de la Recherche Médicale (INSERM), ViroScan3D SAS [Trévoux, France], Laboratoire d’innovation : vaccins – Innovation lab : vaccines, This study was funded by a grant from the Coalition for Epidemic Preparedness and Innovations (CEPI-CfP-001) to S. Baize and by a grant from the Agence Nationale de la Recherche (ANR-21-CE18-0004-01) to M. Mateo., and ANR-21-CE18-0004,EXPUNGER,Vaccins post exposition contre les virus emergents(2021)
Subjects: Multidisciplinary, [SDV]Life Sciences [q-bio], General Physics and Astronomy, General Chemistry, General Biochemistry, Genetics and Molecular Biology
Abstract: Lassa fever hits West African countries annually in the absence of licensed vaccine to limit the burden of this viral hemorrhagic fever. We previously developed MeV-NP, a single-shot vaccine protecting cynomolgus monkeys against divergent strains one month or more than a year before Lassa virus infection. Given the limited dissemination area during outbreaks and the risk of nosocomial transmission, a vaccine inducing rapid protection could be useful to protect exposed people during outbreaks in the absence of preventive vaccination. Here, we test whether the time to protection can be reduced after immunization by challenging measles virus pre-immune male cynomolgus monkeys sixteen or eight days after a single shot of MeV-NP. None of the immunized monkeys develop disease and they rapidly control viral replication. Animals immunized eight days before the challenge are the best controllers, producing a strong CD8 T-cell response against the viral glycoprotein. A group of animals was also vaccinated one hour after the challenge, but was not protected and succumbed to the disease as the control animals. This study demonstrates that MeV-NP can induce a rapid protective immune response against Lassa fever in the presence of MeV pre-existing immunity but can likely not be used as therapeutic vaccine.
Published: 2023

6. Brucella effectors NyxA and NyxB target SENP3 to modulate the subcellular localisation of nucleolar proteins

Author: Arthur Louche, Amandine Blanco, Thais Lourdes Santos Lacerda, Lison Cancade-Veyre, Claire Lionnet, Célia Bergé, Monica Rolando, Frédérique Lembo, Jean-Paul Borg, Carmen Buchrieser, Masami Nagahama, Francine C. A. Gérard, Jean-Pierre Gorvel, Virginie Gueguen-Chaignon, Laurent Terradot, Suzana P. Salcedo, Microbiologie moléculaire et biochimie structurale / Molecular Microbiology and Structural Biochemistry (MMSB), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Reproduction et développement des plantes (RDP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Biologie des Bactéries intracellulaires - Biology of Intracellular Bacteria, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Meiji Pharmaceutical University, Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), SFR Biosciences, Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CB lab was funded by the Institut Pasteur and ANR-10-LABX-62-IBEID for the Legionella experiments. These effectors were discovered under the ERA-Net Pathogenomics grant and the remaining work funded by ANR-15-CE15-0011-01 attributed to Suzana Salcedo. The work was completed with the ANR SNAPshot ANR-21-CE15-0024 attributed to Suzana Salcedo., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-15-CE15-0011,NucPath,Caractérisation du rôle cellulaire de nouveaux effecteurs bactériens ciblant les noyaux des cellules hôtes(2015), ANR-21-CE15-0024,SNAPshot,Détournement du stress nucléaire par les bactéries pathogènes(2021), Laurent, Terradot, Integrative Biology of Emerging Infectious Diseases - - IBEID2010 - ANR-10-LABX-0062 - LABX - VALID, Caractérisation du rôle cellulaire de nouveaux effecteurs bactériens ciblant les noyaux des cellules hôtes - - NucPath2015 - ANR-15-CE15-0011 - AAPG2015 - VALID, Détournement du stress nucléaire par les bactéries pathogènes - - SNAPshot2021 - ANR-21-CE15-0024 - AAPG2021 - VALID, and École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL)
Subjects: [SDV] Life Sciences [q-bio], Multidisciplinary, [SDV]Life Sciences [q-bio], General Physics and Astronomy, General Chemistry, General Biochemistry, Genetics and Molecular Biology
Abstract: The cell nucleus is a primary target for intracellular bacterial pathogens to counteract immune responses and hijack host signalling pathways to cause disease. Here we identify two Brucella abortus effectors, NyxA and NyxB, that interfere with host protease SENP3, and this facilitates intracellular replication of the pathogen. The translocated Nyx effectors directly interact with SENP3 via a defined acidic patch (identified from the crystal structure of NyxB), preventing nucleolar localisation of SENP3 at late stages of infection. By sequestering SENP3, the effectors promote cytoplasmic accumulation of nucleolar AAA-ATPase NVL and ribosomal protein L5 (RPL5) in effector-enriched structures in the vicinity of replicating bacteria. The shuttling of ribosomal biogenesis-associated nucleolar proteins is inhibited by SENP3 and requires the autophagy-initiation protein Beclin1 and the SUMO-E3 ligase PIAS3. Our results highlight a nucleomodulatory function of two Brucella effectors and reveal that SENP3 is a crucial regulator of the subcellular localisation of nucleolar proteins during Brucella infection, promoting intracellular replication of the pathogen.
Published: 2023

7. Ultraviolet exposure regulates skin metabolome based on the microbiome

Author: Vijaykumar Patra, Natalie Bordag, Yohann Clement, Harald Köfeler, Jean-Francois Nicolas, Marc Vocanson, Sophie Ayciriex, Peter Wolf, Medical University Graz, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Medical University of Graz, CheMod, Institut des Sciences Analytiques (ISA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), ANABIO-MS - Analyse biomoléculaire par spectrométrie de masse - Biological Analysis by Mass Spectrometry, BioTechMed-Graz, Graz University of Technology [Graz] (TU Graz)-Karl-Franzens-Universität Graz-Medical University Graz, and Austrian Science Fund (FWF, W1241)
Subjects: [STAT]Statistics [stat], Multidisciplinary, [SDV]Life Sciences [q-bio]
Abstract: Skin metabolites (
Published: 2023

8. Using a manifold-based approach to extract clinical codes associated with winter respiratory viruses at an emergency department

Author: Péalat, Clément, Bouleux, Guillaume, Cheutet, Vincent, Maignan, Maxime, Provoost, Luc, Pillet, Sylvie, Mory, Olivier, Décision et Information pour les Systèmes de Production (DISP), Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), CHU Grenoble, Physiopathologie et biothérapies des infections muqueuses (GIMAP), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)
Subjects: Time Series Clustering, Stiefel manifold, Healthcare management, Monitoring Emergency Departments, Delay coordinate embedding, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract: International audience; Every winter, respiratory viruses put most Emergency Departments (ED) around the world under intense pressure. To reduce the consequent stress for hospitals, anticipation of the massive increase of intakes for illness-based symptoms is essential. As the Covid-19 2020 pandemic clearly illustrates, patients are not systematically tested. The ED staff therefore has no real-time knowledge of the presence of the virus in the patients flow. To address this issue, we propose here to use the hospital's laboratory-confirmed database as an attractor for the manifold-based approach for clustering the clinical codes associated with respiratory viruses. We propose a new framework based on the embedding of time series onto the Stiefel manifold, coupled with a density-based clustering algorithm (HDBSCAN) enhanced by a reduction of dimension (UMAP) for the clustering on that manifold. In particular, we show, based on real data sets of two academic hospitals in France, the significant benefits of using geometrical approaches for time series clustering as compared to traditional methods.
Published: 2023

9. HLA-DR expression on monocytes and outcome of anti-CD19 CAR T-cell therapy for large B-cell lymphoma

Author: Estelle Bourbon, Pierre Sesques, Morgane Gossez, Jérémie Tordo, Emmanuelle Ferrant, Violaine Safar, Florent Wallet, Guillaume Aussedat, Alizée Maarek, Fadhela Bouafia, Lionel Karlin, Dana Ghergus, Camille Golfier, Hélène Lequeu, Anne Lazareth, Vérane Schwiertz, Sébastien Viel, Maryam Idlhaj, Hervé Ghesquières, Guillaume Monneret, Emmanuel Bachy, Fabienne Venet, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Edouard Herriot [CHU - HCL], Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])
Subjects: [SDV]Life Sciences [q-bio], Hematology
Abstract: Despite their unprecedented success in relapsed/refractory (R/R) large B-cell lymphoma (LBCL), anti-CD19 CAR T cells are associated with significant toxicity, and more than half of patients relapse. As monocytes emerged as key players in CAR therapy, we sought to evaluate the evolution of HLA-DR expression on monocytes (mHLA-DR) before and after commercial anti-CD19 CAR T-cell infusion in a large cohort (n = 103) of patients with R/R LBCL and its association with adverse events and treatment response. Cy-Flu-based lymphodepletion (LD) upregulated mHLA-DR in 79% of the cases, whereas in 2l% of cases (15 patients), the mHLA-DR level decreased after LD, and this decrease was associated with poorer outcome. Low mHLA-DR at day minus 7 (D−7) (
Published: 2023

10. Structure, Morphology, and Surface Chemistry of Surgical Masks and Their Evolution up to 10 Washing Cycles

Author: Louise Wittmann, Joseph Garnier, Naomi Sakata, Elisabeth Auzias, Martin Dumoulin, Nathanaël Barlier, Théotime Bergese, Lara Leclerc, Florence Grattard, Paul O. Verhoeven, Jérémie Pourchez, Claude Botella, Jean-Marie Bluet, Béatrice Vacher, José Penuelas, Institut des Nanotechnologies de Lyon (INL), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie et biothérapies des infections muqueuses (GIMAP), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), INL - Matériaux Fonctionnels et Nanostructures (INL - MFN), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Laboratoire de Tribologie et Dynamique des Systèmes (LTDS), Université de Lyon-Université de Lyon-École Nationale des Travaux Publics de l'État (ENTPE)-Ecole Nationale d'Ingénieurs de Saint Etienne (ENISE)-Centre National de la Recherche Scientifique (CNRS), and Université de Lyon
Subjects: [CHIM.POLY]Chemical Sciences/Polymers, Polymers and Plastics, pandemic, Process Chemistry and Technology, Organic Chemistry, washing, surgical masks, decontamination, Covid-19, polypropylene
Abstract: International audience; The Covid-19 crisis has led to a massive surge in the use of surgical masks worldwide, causing risks of shortages and high pollution. Various decontamination techniques are currently being studied to reduce these risks by allowing the reuse of masks. In this study, surgical masks were washed up to 10 times, each cycle under the same conditions. The consequences of the washing cycles on the structure, fiber morphology, and surface chemistry have been studied through several characterization techniques: scanning electron microscopy, wetting angle measurements, infrared spectroscopy, X-ray diffraction, and X-ray photoelectrons spectroscopy. The washing process did not induce large changes in the hydrophobicity of the surface, the contact angle remaining constant throughout the cycles. The composition observed in the IR spectrum also remained unchanged for washed masks up to 10 cycles. Some slight variations were observed during X-ray analysis: the crystallinity of the fibers as well as the size of the crystals increases with the number of wash cycles. The XPS analysis shows that after 10 cycles, the surface of the masks underwent a slight oxidation. In the SEM images, changes were observed in the arrangement of the fibers, which are more visible the more times the mask has been washed: they align themselves in bundles, form areas with holes in the mask layer, and are crushed in some areas.
Published: 2023

11. Cognitive performance is associated with glomerular filtration rate in patients with chronic kidney disease: results from the CKD-REIN cohort

Author: Pépin, Marion, Levassort, Hélène, Boucquemont, Julie, Lambert, Oriane, Alencar de Pinho, Natalia, Turinici, Monica, Helmer, Catherine, Metzger, Marie, Cheddani, Lynda, Frimat, Luc, Combe, Christian, Fouque, Denis, Laville, Maurice, Ayav, Carole, Liabeuf, Sophie, Jacquelinet, Christian, Teillet, Laurent, Stengel, Bénédicte, Massy, Ziad, Choukroun, Gabriel, Hôpital Ambroise Paré [AP-HP], Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Epidemiologie-Biostatistique [Bordeaux], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux Ségalen [Bordeaux 2], Laboratoire Interdisciplinaire de Recherche Appliquée en Economie de la Santé (LIRAES (URP_ 4470)), Université Paris Cité (UPCité), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Evolution, adaptation et comportement, Département écologie évolutive [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Hôpital Hôtel-Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Réseau Lorrain de prise en charge de l’insuffisance rénale chronique : Réseau NEPHROLOR (Nephrolor), Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC), Université de Lorraine (UL), Bioingénierie tissulaire (BIOTIS), Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Néphrologie-transplantation-dialyse [Bordeaux], CHU Bordeaux [Bordeaux], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Service d'Epidémiologie et Evaluations Cliniques [CHRU Nancy] (Pôle S2R), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de Néphrologie [CHRU Nancy], CHU Amiens-Picardie, Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Chronic Kidney Disease - Réseau Epidémiologie et Information en Néphrologie (CKD REIN), Institut National de la Santé et de la Recherche Médicale (INSERM), Service Néphrologie/Dialyse [AP-HP Ambroise-Paré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP], Épidémiologie et recherches translationnelles sur les maladies rénales et cardiovasculaires (EPREC) (U1018 (Équipe 5)), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, and Service de Néphrologie-Dialyse-Transplantation [CHU Amiens-Picardie]
Subjects: cognition, Psychiatry and Mental health, renal medicine, epidemiology, Surgery, Neurology (clinical), [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: BackgroundChronic kidney disease (CKD) is associated with cognitive impairment in general population. We assessed the association between kidney and cognitive functions in patients with CKD and the influence of cardiovascular (CV) risk factors, and depression on this association.MethodsThe CKD-Renal Epidemiology and Information Network cohort included 3033 patients with CKD stages 3–4, followed for 5 years. Cognitive function was assessed with the Mini-Mental State Examination (MMSE) and estimated glomerular filtration rate (eGFR) with the CKD-Epidemiology Collaboration equation-creatinin formula. Evolution of the MMSE score over time and its association with baseline eGFR were investigated with linear mixed models. We assessed the risk of incident cognitive outcome (hospitalisation or death with relevant International Classification of Disease-10 codes), with a Cox proportional hazard model.ResultsThe mean age was 66.8, the mean eGFR was 33 mL/min/1.73 m2and 387 patients (13.0%) had an MMSE score below 24 at baseline. A 10 mL/min/1.73 m2decrement of baseline eGFR was associated with a mean MMSE decrease of 0.12 (95% CI 0.04 to 0.19) after adjustment for demographic characteristics, depression, CV risk factors and disease; but baseline eGFR was not associated with MMSE temporal evolution. HR for cognitive outcome during follow-up (median 2.01 years) associated with a 10 mL/min/1.73 m2decrement of baseline eGFR was 1.35 (1.07, 1.70) (p=0.01) after adjustment.ConclusionsIn patients with CKD, lower eGFR was associated with worse cognitive performance and incident cognitive events, independently of demographics, CV risk factors and depression.Trial registration numberNCT03381950.
Published: 2023

12. The conformation of glutenin polymers in wheat grain: some genetic and environmental factors associated with this important characteristic

Author: Gérard Branlard, Angelina d’Orlando, Ayesha Tahir, Marc Schmutz, Larbi Rhazi, Annie Faye, Thierry Aussenac, Génétique Diversité et Ecophysiologie des Céréales (GDEC), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), BioInformatique et BioStatistiques (BIBS), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), COMSATS University Islamabad (CUI), Institut Charles Sadron (ICS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Transformations et Agro-ressources (UT&A), and UniLaSalle
Subjects: Physiology, [SDV]Life Sciences [q-bio], Plant Science
Abstract: In a previous study we used asymmetric-flow field-flow fractionation to determine the polymer mass (Mw), gyration radius (Rw) and the polydispersity index of glutenin polymers (GPs) in wheat (Triticum aestivum). Here, using the same multi-location trials (4 years, 11 locations, and 192 cultivars), we report the factors that are associated with the conformation (Conf) of the polymers, which is the slope of Log(Rw) versus a function of Log(Mw). We found that Conf varied between 0.285 and 0.740, it had low broad-sense heritability (H2=16.8), and it was significantly influenced by the temperature occurring over the last month of grain filling. Higher temperatures were found to increase Rw and the compactness and sphericity of GPs. Alleles for both high- and low-molecular-weight glutenin subunits had a significant influence on the Conf value. Assuming a Gaussian distribution for Mw, the number of polymers present in wheat grains was computed for different kernel weights and protein concentrations, and it was found to exceed 1012 GPs per grain. Using atomic force microscopy and cryo-TEM, images of GPs were obtained for the first time. Under higher average temperature, GPs became larger and more spherical and consequently less prone to rapid hydrolysis. We propose some orientations that could be aimed at potentially reducing the impact of numerous GPs on people suffering from non-celiac gluten sensitivity.
Published: 2023

13. Influence of storage and buffer composition on the mechanical behavior of flowing red blood cells

Author: Adlan Merlo, Sylvain Losserand, François Yaya, Philippe Connes, Magalie Faivre, Sylvie Lorthois, Christophe Minetti, Elie Nader, Thomas Podgorski, Céline Renoux, Gwennou Coupier, Emilie Franceschini, Biomécanique et Bioingénierie (BMBI), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), Institut de mécanique des fluides de Toulouse (IMFT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères] (LIPhy ), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Laboratoire d'Excellence : Biogenèse et pathologies du globule rouge (Labex Gr-Ex), Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut des Nanotechnologies de Lyon (INL), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Aero-Thermo-Mechanics Department, Université libre de Bruxelles (ULB), Laboratoire Rhéologie et Procédés (LRP), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Service de Biochimie et Biologie Moléculaire Grand Est [HCL, Lyon] (Centre de Biologie et de Pathologie), Hospices Civils de Lyon (HCL), Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), GDR Mécabio, CNRS, and European Project: 615102,EC:FP7:ERC,ERC-2013-CoG,BRAINMICROFLOW(2014)
Subjects: Biophysics, [PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph], [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph]
Abstract: International audience; On-chip study of blood flow has emerged as a powerful tool to assess the contribution of each component of blood to its overall function. Blood has indeed many functions, from gas and nutrient transport to immune response and thermal regulation. Red blood cells play a central role therein, in particular through their specific mechanical properties, that directly influence pressure regulation, oxygen perfusion, or platelet and white cells segregation towards endothelial walls. As the bloom of in-vitro studies has led to the apparition of various storage and sample preparation protocols, we address the question of the robustness of the results involving cell mechanical behavior against this diversity. The effects of three conservation media (EDTA, citrate and glucose-albumin-sodium-phosphate) and storage time on the red blood cell mechanical behavior are assessed under different flow conditions: cell deformability by ektacytometry, shape recovery of cells flowing out of a microfluidic constriction, and cell flipping dynamics under shear flow. The impact of buffer solutions (phosphate-buffered saline and density-matched suspension using iodixanol/Optiprep) are also studied by investigating individual cell flipping dynamics, relative viscosity of cell suspensions and cell structuration under Poiseuille flow. Our results reveal that storing blood samples up to seven days after withdrawal and suspending them in adequate density-matched buffer solutions has in most experiments a moderate effect on the overall mechanical response, with a possible rapid evolution in the first three days after sample collection. SIGNIFICANCE Blood is in intimate contact with all organs in the body, supplying oxygen, nutrients and drugs while removing waste. It carries cells involved in immune response, wound repair and tumor dissemination. Blood is easily collected, revealing the presence of disease through biomarker analysis. It is storable and transfusable. Thus, blood is the subject of many in-vitro studies for research and medical purposes. Guidelines associated to sample preparation or storage conditions have been established, but these may affect its mechanical behavior. In this collaborative study, we provide new guidelines to minimize the impact of specific experimental requirements (e.g. density matching, blood freshness) by focusing on the single or collective motion of red blood cells in a large range of flow conditions.
Published: 2023

14. Cu segregation in Au–Cu nanoparticles exposed to hydrogen atmospheric pressure: how is fcc symmetry maintained?

Author: Q. Wang, A. Nassereddine, D. Loffreda, C. Ricolleau, D. Alloyeau, C. Louis, L. Delannoy, J. Nelayah, H. Guesmi, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Université de Montpellier (UM), Laboratoire Matériaux et Phénomènes Quantiques (MPQ (UMR_7162)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Chimie - UMR5182 (LC), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Réactivité de Surface (LRS), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and ANR-17-CE07-0031,TOTEM,Microscopie Électronique en Transmission Operando et Résolue en Temps pour la Catalyse Hétérogène(2017)
Subjects: [PHYS]Physics [physics], [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, [CHIM]Chemical Sciences, [CHIM.CATA]Chemical Sciences/Catalysis, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], Physical and Theoretical Chemistry
Abstract: International audience; In a recent work [A. Nassereddine et al., Small 2021, 17, 2104571] we reported the atomic-scale structure and dynamics of sub-4 nm sized Au nanoparticles (NPs) supported on titania in H2 at atmospheric pressure obtained by using aberration-corrected environmental transmission electron microscopy (ETEM), density functional theory (DFT) optimizations and ab initio molecular dynamic (AIMD) simulations. Our results showed unstable Au NPs losing their face-centred cubic (fcc) symmetry (from fcc to non-fcc symmetries) and revealed the drastic effect of hydrogen adsorption. In this work, we use the same approach to study the dynamics of equiatomic Au–Cu NPs in the same range of size and the results show an enhanced structural stability upon alloying by Cu. In spite of the morphology evolution from facetted to rounded shapes, the observed Au–Cu NPs are found to keep their fcc symmetry under atmospheric hydrogen pressure. AIMD simulation evidences a Cu segregation process from the sub-surface toward the upper surface layer, and a reversed segregation of Au atoms from the surface towards the sub-surface sites. The analysis of the chemical ordering in the core shows a tendency to a local chemical ordering where Au–Cu hetero-atomic bindings are favoured. The segregating Cu seems to play a major role in reducing the fluxionality of Au–Cu NPs in H2 and thus, maintaining their fcc symmetry.
Published: 2023

15. The dialkylcarbonate route to ionic liquids: purer, safer, greener?

Author: Martin Tiano, Ryan Clark, Laetitia Bourgeois, Margarida Costa Gomes, Catalyse, Polymérisation, Procédés et Matériaux (CP2M), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie - UMR5182 (LC), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and ANR-16-IDEX-0005,IDEXLYON,IDEXLYON(2016)
Subjects: Green Chemistry, Dialkyl, [CHIM]Chemical Sciences, Environmental Chemistry, Pollution, Ionic liquids
Abstract: International audience; The synthesis of ionic liquids can generate large amounts of waste and use toxic or expensive raw materials. In this short review, we focused on one of the most promising pathways to large scale environment-friendly productions of ionic liquids. The “dialkylcarbonate route” has already allowed the preparation of more than one hundred original ion pairs, avoiding the use of pollutant alkylating agents and non-sustainable anion exchange materials, in a halide-free and water-free process.
Published: 2023

16. Latency-Aware Strategies for Deploying Data Stream Processing Applications on Large Cloud-Edge Infrastructure

Author: Laurent Lefèvre, Alexandre da Silva Veith, Marcos Dias De Assuncao, Department of Computer Science [University of Toronto] (DCS), University of Toronto, Ecole de Technologie Supérieure [Montréal] (ETS), Algorithms and Software Architectures for Distributed and HPC Platforms (AVALON), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Laboratoire de l'Informatique du Parallélisme (LIP), and Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Computer Networks and Communications, business.industry, Data stream mining, Computer science, 020206 networking & telecommunications, Cloud computing, 02 engineering and technology, Computer Science Applications, [INFO.INFO-NI]Computer Science [cs]/Networking and Internet Architecture [cs.NI], Hardware and Architecture, Scalability, 0202 electrical engineering, electronic engineering, information engineering, Overhead (computing), 020201 artificial intelligence & image processing, The Internet, Enhanced Data Rates for GSM Evolution, Latency (engineering), business, Software, Edge computing, Information Systems, Computer network
Abstract: International audience; Internet of Things (IoT) applications often require the processing of data streams generated by devices dispersed over a large geographical area. Traditionally, these data streams are forwarded to a distant cloud for processing, thus resulting in high application end-to-end latency. Recent work explores the combination of resources located in clouds and at the edges of the Internet, called cloud-edge infrastructure, for deploying Data Stream Processing (DSP) applications. Most previous work, however, fails to scale to very large IoT settings. This paper introduces deployment strategies for the placement of DSP applications on to cloud-edge infrastructure. The strategies split an application graph into regions and consider regions with stringent time requirements for edge placement. The proposed Aggregate End-to-End Latency Strategy with Region Patterns and Latency Awareness (AELS+RP+LA) decreases the number of evaluated resources when computing an operator’s placement by considering the communication overhead across computing resources. Simulation results show that, unlike the state-of-the-art, AELS+RP+LA scales to environments with more than 100k resources with negligible impact on the application end-to-end latency.
Published: 2023

17. Efficacy and safety of combination targeted therapies in immune-mediated inflammatory disease: the COMBIO study

Author: Lucas Guillo, Benoit Flachaire, Jérôme Avouac, Catherine Dong, Maria Nachury, Guillaume Bouguen, Anthony Buisson, Ludovic Caillo, Mathurin Fumery, Cyrielle Gilletta, Xavier Hébuterne, Pierre Lafforgue, David Laharie, Emmanuel Mahé, Hubert Marotte, Stéphane Nancey, Sébastien Ottaviani, Jean-Hugues Salmon, Guillaume Savoye, Mélanie Serrero, Mathieu Uzzan, Manuelle Viguier, Christophe Richez, Laurent Peyrin-Biroulet, Philipe Seksik, Thao Pham, Philippe Ah-Soune, Nadia Arab, Laurent Beaugerie, Loïs Bolko, Joelle Bonnet, Yoram Bouhnik, Anne Bourrier, Franck Brazier, Franck Carbonnel, Maeva Charkaoui, Isabelle Charlot-Lambrecht, Antoine Chupin, Alice Combier, Marion Couderc, Fabienne Coury-Lucas, Ariadne Desjeux, Nicolas Duveau, Anne Grasland, Jean-Charles Grimaud, Xavier Guennoc, Cécilia Landman, Isabelle Nion-Larmurier, Catherien Leberre, Romain Leenhardt, Aude Le Goffic, Henri Montaudie, Jacques Morel, Thierry Passeron, Jeanne-Marie Perotin Collard, Elodie Poisnel, Vincent Pradel, Martin Soubrier, Harry Sokol, Eric Toussirot, Caroline Trang, My-Linh Trans Minh, Sophie Trijau, Frank Verhoeven, Stéphanie Viennot, Daniel Wendling, Hôpital Nord [CHU - APHM], Rhumatologie [Sainte- Marguerite - APHM] ( Hôpitaux Sud), Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'Hépato-gastro-entérologie [APHP Kremlin-Bicêtre], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Clermont-Ferrand, Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, CHU Amiens-Picardie, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Hospitalier Universitaire de Nice (CHU Nice), Institut du Mouvement et de l’appareil Locomoteur [Hôpital Sainte-Marguerite - APHM] (IML), Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud )-Rhumatologie [Sainte- Marguerite - APHM] ( Hôpitaux Sud), Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Centre Hospitalier Victor Dupouy, Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospices Civils de Lyon (HCL), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Centre Hospitalier Universitaire de Reims (CHU Reims), Vieillissement, Fragilité (VIEFRA - EA 3797), Université de Reims Champagne-Ardenne (URCA), Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Hôpital Beaujon [AP-HP], Immuno-Régulation dans les Maladies Auto-Immunes Inflammatoires et le Cancer - EA 7509 (IRMAIC), Hôpital universitaire Robert Debré [Reims], Immunology from Concept and Experiments to Translation (ImmunoConcept), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Service de Rhumatologie [CHU Pellegrin], Groupe hospitalier Pellegrin, Centre National de Référence des Maladies Auto-Immunes Systémiques Rares de l'Est et du Sud-Ouest (RESO), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service d'Hépato-gastro-entérologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Toulouse [Toulouse], INSERM U1059, SAINBIOSE - Santé, Ingénierie, Biologie, Saint-Etienne (SAINBIOSE-ENSMSE), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Hôpital Charles Nicolle [Rouen]-CHU Rouen
Subjects: Adult, Cohort Studies, Immunomodulating Agents, Crohn Disease, Immune-mediated inflammatory diseases, Hepatology, Gastroenterology, Humans, Tumor Necrosis Factor Inhibitors, Ustekinumab, Molecular targeted therapy, Combination therapy, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; BACKGROUND: Use of a combination of targeted therapies (COMBIO) in patients with refractory/overlapping immune-mediated inflammatory diseases (IMIDs) has increased, but reported data remain scarce. We aimed to assess effectiveness and safety of COMBIO in patients with IMIDs. METHODS: We conducted a French ambispective multicenter cohort study from September 2020 to May 2021, including adults' patients with 1 or 2 IMIDs and treated at least 3-month with COMBIO. RESULTS: Overall, 143 patients were included. The most common IMIDs were Crohn's disease (63.6%), axial spondyloarthritis (37.7%), and ulcerative colitis (14%). Half of patients had only one IMID, of which 60% were Crohn's disease. Mean duration of COMBIO was 274.5±59.3 weeks, and COMBIO persistence at 104 weeks was estimated at 64.1%. The most frequent COMBIOs combined anti-TNF agents with vedolizumab (30%) or ustekinumab (28.7%). Overall, 50% of patients achieved significant and 27% mild-to-moderate improvement in patient-reported outcomes. Extended duration of COMBIO (aOR=1.09; 95% CI: 1.03-1.14; p=0.002) and diagnoses of two IMIDs (aOR=3.46; 95%CI: 1.29-9.26; p=0.013) were associated with significant improvement in patient-reported outcomes. Incidence of serious infection during COMBIO was 4.51 per 100 person-years (95% CI 2.20-8.27) and 5 COMBIOs were discontinued due to adverse events. CONCLUSIONS: COMBIO can be effective and safe in patients with refractory/overlapping IMIDs.
Published: 2023

18. The Dial-a-Ride Problem with School Bell Time Adjustment

Author: Samuel Vercraene, Fabien Lehuédé, Thibaud Monteiro, Olivier Péton, Décision et Information pour les Systèmes de Production (DISP), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université Lumière - Lyon 2 (UL2), Institut National des Sciences Appliquées (INSA)-Université de Lyon, Département Automatique, Productique et Informatique (IMT Atlantique - DAPI), IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Systèmes Logistiques et de Production (SLP ), Laboratoire des Sciences du Numérique de Nantes (LS2N), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Modélisation, Optimisation et DEcision pour la Logistique, l'Industrie et les Services (LS2N - équipe MODELIS), Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École Centrale de Nantes (Nantes Univ - ECN), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Nantes Université (Nantes Univ), IMT Atlantique (IMT Atlantique), and Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS)
Subjects: healthcare logistics, large neighborhood search, paratransit, matheuristic, [INFO]Computer Science [cs], Transportation, school bell time adjustment, [INFO.INFO-RO]Computer Science [cs]/Operations Research [cs.RO], vehicle routing, dial-a-ride problem, Civil and Structural Engineering
Abstract: In this paper, we study a paratransit application in which children are transported every day from their homes to their special schools or medical-social establishments. To optimize this transportation system, the establishments collaborate to propose a joint transportation plan. We propose a new algorithm to jointly build vehicle routes that visit several establishments and simultaneously set the establishments’ opening hours. This algorithm combines a large neighborhood search, the resolution of a route-based model, and the progressive shrinkage of the planning window. It is applied to a real case from the area of Lyon in France, including 34 schools and 575 heterogeneous users served by a heterogeneous fleet of reconfigurable vehicles. On average, we show that in addition to the 10% of saving that can be expected by sharing vehicle routes between schools, 7% of additional savings can be achieved by school bell adjustment. This cost saving also decreases average user ride times and the number of vehicles required, creating longer routes that are more attractive for driver services. Funding: This work was supported by the European Union through the European Regional Development Fund [Grant RA0012500] and by the French Région Auvergne-Rhône-Alpes through the NOMAd project. Supplemental Material: The online appendices are available at https://doi.org/10.1287/trsc.2022.1160 .
Published: 2023

19. Suspending OpenMP Tasks on Asynchronous Events: Extending the Taskwait Construct

Author: Pereira, Romain, Martin, Maël, Roussel, Adrien, Gautier, Thierry, Carribault, Patrick, DAM Île-de-France (DAM/DIF), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Algorithms and Software Architectures for Distributed and HPC Platforms (AVALON), Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Lyon, Institut National de Recherche en Informatique et en Automatique (Inria), Laboratoire en Informatique Haute Performance pour le Calcul et la simulation (LIHPC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction des Applications Militaires (DAM), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay
Subjects: [INFO]Computer Science [cs], [INFO.INFO-DC]Computer Science [cs]/Distributed, Parallel, and Cluster Computing [cs.DC]
Abstract: International audience; Many-core and heterogeneous architectures now require programmers to compose multiple asynchronous programming model to fully exploit hardware capabilities. As a shared-memory parallel programming model, OpenMP has the responsibility of orchestrating the suspension and progression of asynchronous operations occurring on a compute node, such as MPI communications or CUDA/HIP streams. Yet, specifications only come with the task detach(event) API to suspend tasks until an asynchronous operation is completed, which presents a few drawbacks. In this paper, we introduce the design and implementation of an extension on the taskwait construct to suspend a task until an asynchronous event completion. It aims to reduce runtime costs induced by the current solution, and to provide a standard API to automate portable task suspension solutions. The results show twice less overheads compared to the existing task detach clause.
Published: 2023

20. Testing The Sharpness of Known Error Bounds on The Fast Fourier Transform

Author: Brisebarre, Nicolas, Muller, Jean-Michel, Picot, Joris, Arithmétiques des ordinateurs, méthodes formelles, génération de code (ARIC), Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Lyon, Institut National de Recherche en Informatique et en Automatique (Inria), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), École normale supérieure de Lyon (ENS de Lyon), and ANR-20-CE48-0014,NuSCAP,Sûreté numérique pour les preuves assistées par ordinateur(2020)
Subjects: Fast Fourier Transform (FFT), Error analysis, [INFO.INFO-AO]Computer Science [cs]/Computer Arithmetic, Floating-Point arithmetic, [INFO.INFO-MS]Computer Science [cs]/Mathematical Software [cs.MS]
Abstract: International audience; The computation of Fast Fourier Transforms (FFTs) in floating-point arithmetic is inexact due to roundings, and for some applications it can prove very useful to know a tight bound on the final error. Although it can be almost attained by specifically built input values, the best known error bound for the Cooley-Tukey FFT seems to be much larger than most actually obtained errors. Also, interval arithmetic can be used to compute a bound on the error committed with a given set of input values, but it is in general considered hampered with large overestimation. We report results of intensive computations to test the two approaches, in order to estimate the numerical performance of state-of-the-art bounds. Surprisingly enough, we observe that while interval arithmetic-based bounds are overestimated, they remain, in our computations, tighter than general known bounds.
Published: 2023

21. Bit-Stealing Made Legal

Author: Baudon, Thaïs, Radanne, Gabriel, Gonnord, Laure, École normale supérieure de Lyon (ENS de Lyon), Université de Lyon, Université Claude Bernard Lyon 1 (UCBL), Centre National de la Recherche Scientifique (CNRS), Institut National de Recherche en Informatique et en Automatique (Inria), Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), Inria Lyon, Compilation et Analyse, Logiciel et Matériel (CASH), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Lyon, Université Grenoble Alpes (UGA), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Laboratoire de Conception et d'Intégration des Systèmes (LCIS), Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), and Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA)
Subjects: Pattern Matching, [INFO]Computer Science [cs], Algebraic Data Types, Compilation, Data Layouts
Abstract: International audience; Initially present only in functional languages such as OCaml and Haskell, Algebraic Data Types (ADTs) have now become pervasive in mainstream languages, providing nice data abstractions and an elegant way to express functions through pattern matching. Unfortunately, ADTs remain seldom used in low-level programming. One reason is that their increased convenience comes at the cost of abstracting away the exact memory layout of values. Even Rust, which tries to optimize data layout, severely limits control over memory representation. In this article, we present a new approach to specify the data layout of rich data types based on a dual view: a source type, providing a high-level description available in the rest of the code, along with a memory type, providing full control over the memory layout. This dual view allows for better reasoning about memory layout, both for correctness, with dedicated validity criteria linking the two views, and for optimizations that manipulate the memory view. We then provide algorithms to compile constructors and destructors, including pattern matching, to their low-level memory representation. We prove our compilation algorithms correct, implement them in a tool called ribbit that compiles to LLVM IR, and show some early experimental results.
Published: 2023

22. Computed Tomography Image Restoration Using a Quantum-Based Deep Unrolled Denoiser and a Plug-and-Play Framework

Author: Dutta, Sayantan, Nwigbo, Kenule Tuador, MICHETTI, Jerome, Georgeot, Bertrand, Pham, Duong-Hung, Kouamé, Denis, Basarab, Adrian, Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), CoMputational imagINg anD viSion (IRIT-MINDS), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Laboratoire de Physique Théorique (LPT), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche « Matière et interactions » (FeRMI), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Imagerie Ultrasonore, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Aalto University, Finland
Subjects: Plug-and-Play, Unrolling, Quantum image processing, Super-Resolution, [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Quantum denoising, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Deep learning, DIVA, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract: International audience; In this work, we address the problem of cone beam computed tomography (CBCT) image resolution enhancement by exploiting a newly introduced deep unrolled quantum denoiser, based on quantum interaction theory adapted to computational imaging. Following recent advances in image restoration using the Plug-and-Play (PnP) framework, we impose this external deep learning denoiser as a regularizer within the super-resolution (SR) problem. The quantum-based deep unrolled denoiser combined with a computationally efficient way to deal with the degradation operators, and the PnP scheme, result in an original way of approaching the image resolution enhancement problem. Experiments conducted on dental CBCT images are presented to illustrate the efficiency of the proposed model for image resolution enhancement tasks. The numerical results suggest that the proposed method allows better restoration performances compared to existing state-of-the-art approaches.
Published: 2023

23. Engineering fast algorithms for the bottleneck matching problem

Author: Panagiotas, Ioannis, Pichon, Grégoire, Singh, Somesh, Uçar, Bora, Neo4j, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)
Subjects: bipartite graphs, matching, [INFO.INFO-DS]Computer Science [cs]/Data Structures and Algorithms [cs.DS], assignment problem
Abstract: International audience; We investigate the maximum bottleneck matching problem in bipartite graphs. Given a bipartite graph with nonnegative edge weights, the problem is to determine a maximum cardinality matching in which the minimum weight of an edge is the maximum. To the best of our knowledge, there are two widely used solvers for this problem based on two different approaches. There exists a third known approach in the literature, which seems inferior to those two which is presumably why there is no implementation of it. We take this third approach, make theoretical observations to improve its behavior, and implement the improved method. Experiments with the existing two solvers show that their run time can be too high to be useful in many interesting cases. Furthermore, their performance is not predictable, and slight perturbations of the input graph lead to considerable changes in the run time. On the other hand, the proposed solver's performance is much more stable; it is almost always faster than or comparable to the two existing solvers, and its run time always remains low.
Published: 2023

24. Implicit Differentiation for Hyperparameter Tuning the Weighted Graphical Lasso

Author: Pouliquen, Can, Gonçalves, Paulo, Massias, Mathurin, Vayer, Titouan, Optimisation, Connaissances pHysiques, Algorithmes et Modèles (OCKHAM), Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Institut Rhône-Alpin des systèmes complexes (IXXI), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Inria Lyon, Institut National de Recherche en Informatique et en Automatique (Inria), Laboratoire de Droit des Affaires et Nouvelles Technologies (DANTE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), ANR-19-CHIA-0009,AllegroAssai,Algorithmes, Approximations, Parcimonie et Plongements pour l'IA(2019), Dynamic Networks : Temporal and Structural Capture Approach (DANTE), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire de l'Informatique du Parallélisme (LIP), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut Rhône-Alpin des systèmes complexes (IXXI), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)
Subjects: FOS: Computer and information sciences, Optimization, Computer Science - Machine Learning, Implicit differentiation, Machine Learning (stat.ML), Hyperparameter Selection, Machine Learning (cs.LG), Graphical Lasso, Optimization and Control (math.OC), Statistics - Machine Learning, FOS: Mathematics, [INFO]Computer Science [cs], [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], Mathematics - Optimization and Control
Abstract: International audience; We provide a framework and algorithm for tuning the hyperparameters of the Graphical Lasso via a bilevel optimizationproblem solved with a first-order method. In particular, we derive the Jacobian of the Graphical Lasso solution with respect to itsregularization hyperparameters.
Published: 2023

25. Hector: A Framework to Design and Evaluate Scheduling Strategies in Persistent Key-Value Stores

Author: Canon, Louis-Claude, Dugois, Anthony, Marchal, Loris, Rivière, Etienne, Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC), École normale supérieure de Lyon (ENS de Lyon), Optimisation des ressources : modèles, algorithmes et ordonnancement (ROMA), Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Lyon, Institut National de Recherche en Informatique et en Automatique (Inria), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), Institute of Information and Communication Technologies, Electronics and Applied Mathematics (ICTEAM), and Université Catholique de Louvain = Catholic University of Louvain (UCL)
Subjects: [INFO.INFO-PF]Computer Science [cs]/Performance [cs.PF], [INFO.INFO-DB]Computer Science [cs]/Databases [cs.DB], Scheduling, Performance, Key-Value Stores, Replica, Modularity, [INFO]Computer Science [cs]
Abstract: International audience; Key-value stores distribute data across several storage nodes to handle large amounts of parallel requests. Proper scheduling of these requests impacts the quality of service, as measured by achievable throughput and (tail) latencies. In addition to scheduling, performance heavily depends on the nature of the workload and the deployment environment. It is, unfortunately, difficult to evaluate different scheduling strategies consistently under the same operational conditions. Moreover, such strategies are often hard-coded in the system, limiting flexibility. We present Hector, a modular framework for implementing and evaluating scheduling policies in Apache Cassandra. Hector enables users to select among several options for key components of the scheduling workflow, from the request propagation via replica selection to the local ordering of incoming requests at a storage node. We demonstrate the capabilities of Hector by comparing strategies in various settings. For example, we find that leveraging cache locality effects may be of particular interest: we propose a new replica selection strategy, called Popularity-Aware, that can support 6 times the maximum throughput of the default algorithm under specific key access patterns. We also show that local scheduling policies have a significant effect when parallelism at each storage node is limited.
Published: 2023

26. Investigating Dependency Graph Discovery Impact on Task-based MPI+OpenMP Applications Performances

Author: Pereira, Romain, Roussel, Adrien, Carribault, Patrick, Gautier, Thierry, DAM Île-de-France (DAM/DIF), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Algorithms and Software Architectures for Distributed and HPC Platforms (AVALON), Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Lyon, Institut National de Recherche en Informatique et en Automatique (Inria), Laboratoire en Informatique Haute Performance pour le Calcul et la simulation (LIHPC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction des Applications Militaires (DAM), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay
Subjects: HPC, Task, Dependency, OpenMP, MPI, [INFO]Computer Science [cs], [INFO.INFO-DC]Computer Science [cs]/Distributed, Parallel, and Cluster Computing [cs.DC], Graph
Abstract: International audience; The architecture of supercomputers is evolving to expose massive parallelism. MPI and OpenMP are widely used in application codes on the largest supercomputers in the world. The community primarily focused on composing MPI with OpenMP before its version 3.0 introduced task-based programming. Recent advances in OpenMP task model and its interoperability with MPI enabled fine model composition and seamless support for asynchrony. Yet, OpenMP tasking overheads limit the gain of task-based applications over their historical loop parallelization (parallel for construct).This paper identifies the OpenMP task dependency graph discovery speed as a limiting factor in the performance of task-based applications.We study its impact on intra and inter-node performances over two benchmarks (Cholesky, HPCG) and a proxy-application (LULESH). We evaluate the performance impacts of several discovery optimizations, and introduce a persistent task dependency graph reducing overheads by a factor upto 15 at run-time. We measure 2x speedup over parallel for versions weak scaled to 16K cores, due to improved cache memory use and communication overlap, enabled by task refinement and depth-first scheduling.
Published: 2023

27. Breeding factors of dairy cows and milk lipolysis and consequences of milk lipolysis on semi-hard cheese and fresh cream

Author: Hurtaud, Catherine, Bernard, Laurence, Thierry, Anne, Garric, Gilles, Harel-Oger, Marielle, Cebo, C, Département PEGASE [LBBE] (PEGASE), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche sur les Herbivores - UMR 1213 (UMRH), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Science et Technologie du Lait et de l'Oeuf (STLO), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Rennes Angers, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Génétique Animale et Biologie Intégrative (GABI), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and American dairy science Association
Subjects: milk lipolysis, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Breeding factors, semi-hard cheese, dairy cows, fresh cream
Abstract: International audience
Published: 2023

28. Does mast seeding shape mating time in wild boar? A comparative study

Author: Jessica Cachelou, Christine Saint-Andrieux, Eric Baubet, Eveline Nivois, Emmanuelle Richard, Jean-Michel Gaillard, Marlène Gamelon, Département écologie évolutive [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), and Office français de la biodiversité (OFB)
Subjects: Quercus, Swine, [SDV]Life Sciences [q-bio], Climate Change, Reproduction, Sus scrofa, Animals, Female, General Agricultural and Biological Sciences, Agricultural and Biological Sciences (miscellaneous), Global Warming
Abstract: In seasonal environments, the timing of reproduction often matches with the peak of food resources. One well-known effect of global warming is an earlier phenology of resources, leading to a possible mismatch between the timing of reproduction for consumers and food peak. However, global warming may also change the dynamics of food resources, such as the intensity and frequency of pulsed mast seeding. How quantitative changes in mast seeding influence the timing of reproduction of seed consumers remains unexplored. Here, we assess how yearly variation in mast seeding influences mating time in wild boar ( Sus scrofa ), a widespread seed consumer species. We took advantage of the intensive monitoring of both female reproduction (1636 females) and acorn production over 6 consecutive years across 15 populations of wild boar in the wild. We found that mating time occurs earlier when acorn production increases in most but not all populations. In two out of 15 populations, heavy females mated earlier than light ones. Our findings demonstrate that mast seeding advances the mating time in some populations, which could perhaps impact how boars respond to climate change.
Published: 2023

29. First pollen record from the Late Holocene forest environment in the Lesser Caucasus

Author: Joannin, Sébastien, Ollivier, Vincent, Bellier, Olivier, Brossier, Benoît, Mourier, Brice, Tozalakyan, Petros, Colombié, Claude, Yevadian, Maxime, Boris, Gasparyan, Malinsky-Buller, Ariel, Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Laboratoire méditerranéen de préhistoire Europe-Afrique (LAMPEA), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés (LEHNA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS), Institute of Geological Sciences of the National Academy of Sciences of Armenia (IGS NAS RA), National Academy of Sciences of the Republic of Armenia [Yerevan] (NAS RA), Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement (LGL-TPE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Université Catholique de Lyon (UCLy) (UCLy), The Hebrew University of Jerusalem (HUJ), and Monrepos Archaeological Research Centre and Museum for Human Behavioural Evolution
Subjects: [SDE]Environmental Sciences
Abstract: Pollen-based vegetation change has been inferred from sediments in Kalavan Red Lake. This small lake is placed in the beech-oak-hornbeam forest, about three kilometres away from archaeological remains. It has the potential to document the Holocene forest history and climate and human impacts on the Lesser Caucasus, West of the Caspian Sea. However, this lake happens to be formed by a large landslide.Pollen and XRF analysis are provided over the last 3800 years. The basal age of the Kalavan sediment approximates the landslide age. This created a not vegetated slope including the lake catchment. Erosion and sedimentation processes brought coarse and heavy minerogenic elements, declining with the catchment revegetation by tall-grassland. This shift in the sedimentation continues, suggesting less erosion in the catchment when an admixture of Quercus and grasslands settled. Starting from 2000 cal. BP, arboreal pollen increases successively thanks to the step afforestation of Quercus, Carpinus orientalis and Fagus.The comparison with available pollen reconstruction illustrates the uniqueness of the vegetation dynamic recorded at Kalavan. However, the duration of this succession is also questionable. An intermediate hypothesis is proposed: the Kalavan’s dynamic is first initiated by the landslide with the tall-grass development, then paced by the regional vegetation dynamic.Linking vegetation history and erosion with regional climate and archaeological data helps to evidence short-term climate change and human impact on this branch of the Silk Road. Antique arid phase (2000-1600 cal. BP), the Medieval Warm Period and Little Ice Age affect the vegetation, while demography variations during the Medieval period and Modern Age are shown by habitation and pastoral activity.
Published: 2023

30. Towards a correctly-rounded and fast power function in binary64 arithmetic

Author: Hubrecht, Tom, Jeannerod, Claude-Pierre, Zimmermann, Paul, Département d'informatique - ENS Paris (DI-ENS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), Arithmétiques des ordinateurs, méthodes formelles, génération de code (ARIC), Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Lyon, Institut National de Recherche en Informatique et en Automatique (Inria), Cryptology, arithmetic : algebraic methods for better algorithms (CARAMBA), Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Department of Algorithms, Computation, Image and Geometry (LORIA - ALGO), Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), and Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
Subjects: efficiency, IEEE 754, IEEE 754 double precision binary64 format power function correct rounding efficiency, double precision, power function, [INFO]Computer Science [cs], correct rounding, binary64 format
Abstract: This is the extended version of an article published in the proceedings of ARITH 2023.; We design algorithms for the correct rounding of the power function x y in the binary64 IEEE 754 format, for all rounding modes, modulo the knowledge of hardest-to-round cases. Our implementation of these algorithms largely outperforms previous correctly-rounded implementations and is not far from the efficiency of current mathematical libraries, which are not correctly-rounded. Still, we expect our algorithms can be further improved for speed. The proofs of correctness are fully detailed, with the goal to enable a formal proof of these algorithms. We hope this work will motivate the next IEEE 754 revision committee to require correct rounding for mathematical functions.
Published: 2023

31. Quantum Channel Certification with Incoherent Strategies

Author: Fawzi, Omar, Flammarion, Nicolas, Garivier, Aurélien, Oufkir, Aadil, Traitement optimal de l'information avec des dispositifs quantiques (QINFO), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Grenoble Alpes (UGA)-Inria Lyon, Institut National de Recherche en Informatique et en Automatique (Inria), Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), Ecole Polytechnique Fédérale de Lausanne (EPFL), Unité de Mathématiques Pures et Appliquées (UMPA-ENSL), École normale supérieure de Lyon (ENS de Lyon)-Centre National de la Recherche Scientifique (CNRS), ANR-20-CHIA-0020,SeqALO,Apprentissage séquentiel et actif pour l'optimisation(2020), European Project: 851716,ERC-2019-STG,AlgoQIP(2021), and European Project: 101017733 ,QuantERA II
Subjects: FOS: Computer and information sciences, [STAT]Statistics [stat], Quantum Physics, Computer Science - Information Theory, Information Theory (cs.IT), Computer Science - Data Structures and Algorithms, FOS: Physical sciences, Data Structures and Algorithms (cs.DS), [INFO]Computer Science [cs], Quantum Physics (quant-ph)
Abstract: In the problem of quantum channel certification, we have black box access to a quantum process and would like to decide if this process matches some predefined specification or is $\varepsilon$-far from this specification. The objective is to achieve this task while minimizing the number of times the black box is used. Here, we focus on optimal incoherent strategies for two relevant extreme cases of channel certification. The first one is when the predefined specification is a unitary channel, e.g., a gate in a quantum circuit. In this case, we show that testing whether the black box is described by a fixed unitary operator in dimension $d$ or $\varepsilon$-far from it in the trace norm requires $\Theta(d/\varepsilon^2)$ uses of the black box. The second setting we consider is when the predefined specification is a completely depolarizing channel with input dimension $d_{\text{in}}$ and output dimension $d_{\text{out}}$. In this case, we prove that, in the non-adaptive setting, $\tilde{\Theta}(d_{\text{in}}^2d_{\text{out}}^{1.5}/\varepsilon^2)$ uses of the channel are necessary and sufficient to verify whether it is equal to the depolarizing channel or $\varepsilon$-far from it in the diamond norm. Finally, we prove a lower bound of $\Omega(d_{\text{in}}^2d_{\text{out}}/\varepsilon^2)$ for this problem in the adaptive setting. Note that the special case $d_{\text{in}} = 1$ corresponds to the well-studied quantum state certification problem., Comment: The lower bounds are generalized to ancilla assisted strategies
Published: 2023

32. Algebraic Recognition of Regular Functions

Author: Bojańczyk, Mikołaj, Nguyễn, Lê Thành Dũng (Tito), Faculty of Mathematics, Informatics, and Mechanics [Warsaw] (MIMUW), University of Warsaw (UW), Preuves et Langages (PLUME), Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), Kousha Etessami, Uriel Feige, Gabriele Puppis, and ANR-10-LABX-0070,MILYON,Community of mathematics and fundamental computer science in Lyon(2010)
Subjects: category theory, [INFO]Computer Science [cs], Theory of computation → Transducers, string transducers, semigroups
Abstract: We consider regular string-to-string functions, i.e. functions that are recognized by copyless streaming string transducers, or any of their equivalent models, such as deterministic two-way automata. We give yet another characterization, which is very succinct: finiteness-preserving functors from the category of semigroups to itself, together with a certain output function that is a natural transformation., LIPIcs, Vol. 261, 50th International Colloquium on Automata, Languages, and Programming (ICALP 2023), pages 117:1-117:19
Published: 2023

33. C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3 -Mutant Leukemia

Author: Marie Sabatier, Rudy Birsen, Laura Lauture, Sarah Mouche, Paolo Angelino, Jonas Dehairs, Lea Goupille, Ismael Boussaid, Mael Heiblig, Emeline Boet, Ambrine Sahal, Estelle Saland, Juliana C. Santos, Marc Armengol, Miranda Fernandez-Serrano, Thomas Farge, Guillaume Cognet, Federico Simonetta, Corentin Pignon, Antoine Graffeuil, Celine Mazzotti, Herve Avet-Loiseau, Oceane Delos, Justine Bertrand-Michel, Amelie Chedru, Vilma Dembitz, Paolo Gallipoli, Natasha S. Anstee, Sun Loo, Andrew H. Wei, Martin Carroll, Armelle Goubard, Remy Castellano, Yves Collette, Francois Vergez, Veronique Mansat-De Mas, Sarah Bertoli, Suzanne Tavitian, Muriel Picard, Christian Recher, Nathalie Bourges-Abella, Fanny Granat, Olivier Kosmider, Pierre Sujobert, Benoit Colsch, Carine Joffre, Lucille Stuani, Johannes V. Swinnen, Herve Guillou, Gael Roue, Nawad Hakim, Anne S. Dejean, Petros Tsantoulis, Clement Larrue, Didier Bouscary, Jerome Tamburini, Jean-Emmanuel Sarry, Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Faculté de médecine [Genève], Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Lausanne = University of Lausanne (UNIL), Leuven Cancer Institute [Leuven, Belgium] (LKI), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Hospices Civils de Lyon (HCL), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Josep Carreras Leukaemia Research Institute (IJC), MetaboHUB-MetaToul, MetaboHUB-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Queen Mary University of London (QMUL), The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Peter MacCallum Cancer Center, Perelman School of Medicine, University of Pennsylvania, Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Régional d'Exploration Fonctionnelle et Ressources Expérimentales (CREFRE), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Leuven Cancer Institute (LKI), Leuven, Belgium, ToxAlim (ToxAlim), Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université de Genève = University of Geneva (UNIGE), and 2018/Ligue Nationale de Lutte contre le Cancer C57799/A27964/Cancer Research UK (CRUK) Institut National Du Cancer (INCa)
Subjects: Oncology, [SDV]Life Sciences [q-bio]
Abstract: Although transcription factor CCAAT-enhancer binding protein α (C/EBPα) is critical for normal and leukemic differentiation, its role in cell and metabolic homeostasis is largely unknown in cancer. Here, multiomics analyses uncovered a coordinated activation of C/EBPα and Fms-like tyrosine kinase 3 (FLT3) that increased lipid anabolism in vivo and in patients with FLT3-mutant acute myeloid leukemia (AML). Mechanistically, C/EBPα regulated the fatty acid synthase (FASN)–stearoyl-CoA desaturase (SCD) axis to promote fatty acid (FA) biosynthesis and desaturation. We further demonstrated that FLT3 or C/EBPα inactivation decreased monounsaturated FA incorporation to membrane phospholipids through SCD downregulation. Consequently, SCD inhibition enhanced susceptibility to lipid redox stress that was exploited by combining FLT3 and glutathione peroxidase 4 inhibition to trigger lipid oxidative stress, enhancing ferroptotic death of FLT3-mutant AML cells. Altogether, our study reveals a C/EBPα function in lipid homeostasis and adaptation to redox stress, and a previously unreported vulnerability of FLT3-mutant AML to ferroptosis with promising therapeutic application. Significance: FLT3 mutations are found in 30% of AML cases and are actionable by tyrosine kinase inhibitors. Here, we discovered that C/EBPα regulates FA biosynthesis and protection from lipid redox stress downstream mutant-FLT3 signaling, which confers a vulnerability to ferroptosis upon FLT3 inhibition with therapeutic potential in AML. This article is highlighted in the In This Issue feature, p. 1501
Published: 2023

34. Natal environmental conditions modulate senescence of antler length in roe deer

Author: Cambreling, Solène, Gaillard, Jean-Michel, Pellerin, Maryline, Vanpé, Cécile, Débias, François, Delorme, Daniel, Garcia, Rébecca, Hewison, A, Lemaître, Jean-François, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Office français de la biodiversité (OFB), Unité de recherche Comportement et Ecologie de la Faune Sauvage (CEFS), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Biodémographie évolutive, Département écologie évolutive [LBBE], Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), and Ecologie et évolution des populations
Subjects: secondary sexual traits, weapon, [SDV.BA.ZV]Life Sciences [q-bio]/Animal biology/Vertebrate Zoology, reproductive ageing, Capreolus capreolus, sexual selection, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, [SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction
Abstract: It is now broadly admitted that female reproductive senescencea decline in reproductive performance with increasing ageoccurs in most species, at least among birds and mammals. Although information is more limited, male reproductive senescence has been regularly inferred from the decline in the size or performance of phenotypic traits that underly male reproductive success, particularly secondary sexual traits. However, the degree to which environmental conditions influence the pattern of senescence in sexual traits remains largely unknown. From the analysis of two long-term studies of populations of European roe deer (Capreolus capreolus) subjected to markedly different environmental contexts in the wild, we tested the hypothesis that harsh natal and/or current conditions should lead to earlier and/or stronger rates of senescence in the length of fully-grown antlers than good natal and/or current conditions. We found evidence of similar patterns of antler length senescence in both populations, with an onset of senescence around 7 years of age and a decrease of length by about 1-1.5 cm per additional year of life from 7 years of age onwards. We found that good early-life conditions delay senescence in antler length in roe deer. Our results also revealed that senescent males seem to be unable to allocate substantially to antler growth, confirming that antler size is, therefore, an honest signal of male individual quality. By modulating age-specific allocation to secondary sexual traits, natal and current conditions could influence female mate choice and male-male competition over mates, and as a result age-specific reproductive success, and should be accounted for when studying the dynamics of sexual selection.
Published: 2023

35. Euclid: Constraining linearly scale-independent modifications of gravity with the spectroscopic and photometric primary probes

Author: Frusciante, N., Pace, F., Cardone, V. F., Casas, S., Tutusaus, I., Ballardini, M., Bellini, E., Benevento, G., Bose, B., Valageas, P., Bartolo, N., Brax, P., Ferreira, P. G., Finelli, F., Koyama, K., Legrand, L., Lombriser, L., Paoletti, D., Pietroni, M., Rozas-Fernández, A., Sakr, Z., Silvestri, A., Vernizzi, F., Winther, H. A., Aghanim, N., Amendola, L., Auricchio, N., Azzollini, R., Baldi, M., Bonino, D., Branchini, E., Brescia, M., Brinchmann, J., Camera, S., Capobianco, V., Carbone, C., Carretero, J., Castellano, M., Cavuoti, S., Cimatti, A., Cledassou, R., Congedo, G., Conversi, L., Copin, Y., Corcione, L., Courbin, F., Cropper, M., Da Silva, A., Degaudenzi, H., Dinis, J., Dubath, F., Dupac, X., Dusini, S., Farrens, S., Ferriol, S., Fosalba, P., Frailis, M., Franceschi, E., Galeotta, S., Gillis, B., Giocoli, C., Grazian, A., Grupp, F., Guzzo, L., Haugan, S. V. H., Holmes, W., Hormuth, F., Hornstrup, A., Jahnke, K., Kermiche, S., Kiessling, A., Kilbinger, M., Kitching, T., Kunz, M., Kurki-Suonio, H., Ligori, S., Lilje, P. B., Lloro, I., Maiorano, E., Mansutti, O., Marggraf, O., Markovic, K., Marulli, F., Massey, R., Medinaceli, E., Meneghetti, M., Meylan, G., Moresco, M., Moscardini, L., Munari, E., Niemi, S. M., Nightingale, J., Padilla, C., Paltani, S., Pasian, F., Pedersen, K., Percival, W. J., Pettorino, V., Polenta, G., Poncet, M., Popa, L., Raison, F., Rebolo, R., Renzi, A., Rhodes, J., Riccio, G., Romelli, E., Saglia, R., Sapone, D., Sartoris, B., Secroun, A., Seidel, G., Sirignano, C., Sirri, G., Stanco, L., Surace, C., Tallada-Crespí, P., Taylor, A. N., Tereno, I., Toledo-Moreo, R., Torradeflot, F., Valentijn, E. A., Valenziano, L., Vassallo, T., Kleijn, G. A. Verdoes, Wang, Y., Zacchei, A., Zamorani, G., Zoubian, J., Scottez, V., Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut de Physique Théorique - UMR CNRS 3681 (IPHT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut Camille Jordan (ICJ), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Centre National d'Études Spatiales [Toulouse] (CNES), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Agence Spatiale Européenne = European Space Agency (ESA), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), and Euclid
Subjects: Astrophysics and Astronomy, dimension: 5, Cosmology and Nongalactic Astrophysics (astro-ph.CO), gravitation: model, perturbation, gr-qc, scalar tensor, satellite, multipole, FOS: Physical sciences, General Relativity and Quantum Cosmology (gr-qc), Brans-Dicke model, General Relativity and Quantum Cosmology, membrane model, embedding, gravitation: lens, invariance: scale, matter: coupling, statistical analysis, cosmological model: parameter space, general relativity, Dvali-Gabadadze-Porrati model, universality, correlation function, Minkowski, Jordan, General Relativity and Cosmology, screening, field theory: scalar, confidence limit, astro-ph.CO, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], nonlinear, galaxy: cluster, higher-dimensional, k-essence, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: The future Euclid space satellite mission will offer an invaluable opportunity to constrain modifications to general relativity at cosmic scales. We focus on modified gravity models characterised, at linear scales, by a scale-independent growth of perturbations while featuring different testable types of derivative screening mechanisms at smaller nonlinear scales. We consider 3 specific models, namely Jordan-Brans-Dicke (JBD), the normal branch of Dvali-Gabadadze-Porrati (nDGP) gravity and $k$-mouflage (KM) gravity. We provide forecasts from spectroscopic and photometric primary probes by Euclid on the cosmological parameters and the extra parameters of the models, respectively, $\omega_{\rm BD}$, $\Omega_{\rm rc}$ and $\epsilon_{2,0}$, which quantify the deviations from general relativity. This analysis will improve our knowledge of the cosmology of these modified gravity models. The forecasts analysis employs the Fisher matrix method applied to weak lensing (WL); photometric galaxy clustering (GC$_{ph}$); spectroscopic galaxy clustering (GC$_{sp}$) and the cross-correlation (XC) between GC$_{ph}$ and WL. For the Euclid survey specifications we define three scenarios, characterised by different cuts in $\ell$ and $k$, to assess the constraining power of nonlinear scales. For each model we consider two fiducial values for the corresponding model parameter. In an optimistic setting at 68.3\% confidence interval, with Euclid alone we find the following percentage relative errors: for $\log_{10}{\omega_{\rm BD}}$, with a fiducial value of $\omega_{\rm BD}=800$, 35% using GC$_{sp}$ alone, 3.6% using GC$_{ph}$+WL+XC and 3.3% using GC$_{ph}$+WL+XC+GC$_{sp}$; for $\log_{10}{\Omega_{\rm rc}}$, with a fiducial value of $\Omega_{\rm rc}=0.25$, we find respectively 90%, 20% and 17%; finally, for $\epsilon_{2,0}=-0.04$ respectively 5%, 0.15% and 0.14%. (abridged), Comment: 22 pages, 9 figures, 4 tables, 1 appendix
Published: 2023

36. Quanto \'e importante risolvere e far risolvere problemi?

Author: Gilles Aldon, Sciences et Société, Historicité, Éducation et Pratiques (EA S2HEP), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, and École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL)
Subjects: History and Overview (math.HO), Mathematics - History and Overview, epistemologia, 16. Peace & justice, apprendimento della matematica, Mathematical research, Education, esperimenti, [MATH.MATH-GM]Mathematics [math]/General Mathematics [math.GM], Work (electrical), problem solving, situazione didattica, FOS: Mathematics, Mathematics education, QA1-939, Heuristics, Mathematics
Abstract: Doing mathematics implies three levels of manipulation: manipulating the abstract, manipulating symbols and manipulating logic. Teaching mathematics therefore involves the teacher proposing situations in which pupils can explore a small part of mathematics through these manipulations. In doing so, the pupils work on both the heuristics enabling them to confront themselves with a real mathematical research and knowledge in construction. Through examples of didactic situations of problem solving, this article aims to show how problems can be drivers of mathematics learning., in Italian language
Published: 2023

37. Exploiting data locality to maximize the performance of data-sharing tasksets

Author: Gonthier, Maxime, École normale supérieure de Lyon (ENS de Lyon), Optimisation des ressources : modèles, algorithmes et ordonnancement (ROMA), Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Lyon, and Institut National de Recherche en Informatique et en Automatique (Inria)
Subjects: GPUs, Memory-aware scheduling, Eviction policy, Runtime systems, [INFO.INFO-DC]Computer Science [cs]/Distributed, Parallel, and Cluster Computing [cs.DC], Tasks sharing data
Abstract: National audience; The use of accelerators such as GPUs has become mainstream to achieve high performance on modern computing systems. GPUs come with their own (limited) memory and are connected to the main memory of the machine through a bus (with limited bandwidth). When a computation is started on a GPU, the corresponding data needs to be transferred to the GPU before the computation starts. Such data movements may become a bottleneck for performance, especially when several GPUs have to share the communication bus. Task-based runtime schedulers have emerged as a convenient and efficient way to use such heterogeneous platforms. With such systems, the scheduler has the ability to choose which task to allocate to which GPU and to reorder tasks so as to minimize data movements. We focus on this problem of partitioning and ordering tasks that share some of their input data. We present a novel dynamic strategy based on data selection, to efficiently allocate tasks to GPUs, and a custom eviction policy. We compare them to existing strategies using standard scheduling techniques in runtime systems. All strategies have been implemented on top of the StarPU runtime, and we show that our dynamic strategy achieves better performance when scheduling tasks on multiple GPUs with limited memory.
Published: 2023

38. Euclid: Constraints on f(R) cosmologies from the spectroscopic and photometric primary probes

Author: Casas, S., Cardone, V. F., Sapone, D., Frusciante, N., Pace, F., Parimbelli, G., Archidiacono, M., Koyama, K., Tutusaus, I., Camera, S., Martinelli, M., Pettorino, V., Sakr, Z., Lombriser, L., Silvestri, A., Pietroni, M., Vernizzi, F., Kunz, M., Kitching, T., Pourtsidou, A., Lacasa, F., Carbone, C., Garcia-Bellido, J., Aghanim, N., Altieri, B., Amara, A., Auricchio, N., Baldi, M., Bodendorf, C., Branchini, E., Brescia, M., Brinchmann, J., Capobianco, V., Carretero, J., Castellano, M., Cavuoti, S., Cimatti, A., Cledassou, R., Congedo, G., Conselice, C. J., Conversi, L., Copin, Y., Corcione, L., Courbin, F., Courtois, H. M., DaSilva, A., Degaudenzi, H., Dubath, F., Duncan, C. A. J., Dupac, X., Dusini, S., Farrens, S., Ferriol, S., Fosalba, P., Frailis, M., Franceschi, E., Fumana, M., Galeotta, S., Garilli, B., Gillard, W., Gillis, B., Giocoli, C., Grazian, A., Grupp, F., Guzzo, L., Haugan, S. V. H., Hormuth, F., Hornstrup, A., Hudelot, P., Jahnke, K., Kermiche, S., Kiessling, A., Kilbinger, M., Kurki-Suonio, H., Ligori, S., Lilje, P. B., Lloro, I., Maiorano, E., Mansutti, O., Marggraf, O., Marulli, F., Massey, R., Medinaceli, E., Mellier, Y., Meneghetti, M., Merlin, E., Meylan, G., Moresco, M., Moscardini, L., Munari, E., Niemi, S. -M., Padilla, C., Paltani, S., Pasian, F., Pedersen, K., Percival, W. J., Pires, S., Polenta, G., Poncet, M., Popa, L. A., Raison, F., Renzi, A., Rhodes, J., Riccio, G., Romelli, E., Roncarelli, M., Rossetti, E., Saglia, R., Sartoris, B., Scottez, V., Secroun, A., Seidel, G., Serrano, S., Sirignano, C., Sirri, G., Stanco, L., Starck, J. -L., Surace, C., Tallada-Crespí, P., Taylor, A. N., Tereno, I., Toledo-Moreo, R., Torradeflot, F., Valentijn, E. A., Valenziano, L., Vassallo, T., Wang, Y., Weller, J., Zoubian, J., Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut Camille Jordan (ICJ), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Théorique - UMR CNRS 3681 (IPHT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Centre National d'Études Spatiales [Toulouse] (CNES), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Agence Spatiale Européenne = European Space Agency (ESA), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Département d'Astrophysique (ex SAP) (DAP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), and Euclid
Subjects: Cosmology and Nongalactic Astrophysics (astro-ph.CO), [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], FOS: Physical sciences, General Relativity and Quantum Cosmology (gr-qc), [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], General Relativity and Quantum Cosmology, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: $\textit{Euclid}$ will provide a powerful compilation of data including spectroscopic redshifts, the angular clustering of galaxies, weak lensing cosmic shear, and the cross-correlation of these last two photometric observables. In this study we extend recently presented $\textit{Euclid}$ forecasts into the Hu-Sawicki $f(R)$ cosmological model, a popular extension of the Hilbert-Einstein action that introduces an universal modified gravity force in a scale-dependent way. Our aim is to estimate how well future $\textit{Euclid}$ data will be able to constrain the extra parameter of the theory, $f_{R0}$, for the range in which this parameter is still allowed by current observations. For the spectroscopic probe, we use a phenomenological approach for the scale dependence of the growth of perturbations in the terms related to baryon acoustic oscillations and redshift-space distortions. For the photometric observables, we use a fitting formula that captures the modifications in the non-linear matter power spectrum caused by the $f(R)$ model. We show that, in an optimistic setting, and for a fiducial value of $f_{R0} = 5 \times 10^{-6}$, $\textit{Euclid}$ alone will be able to constrain the additional parameter $\log f_{R0}$ at the $3\%$ level, using spectroscopic galaxy clustering alone; at the $1.4\%$ level, using the combination of photometric probes on their own; and at the $1\%$ level, using the combination of spectroscopic and photometric observations. This last constraint corresponds to an error of the order of $6 \times 10^{-7}$ at the $1\sigma$ level on the model parameter $f_{R0} = 5 \times 10^{-6}$. We report also forecasted constraints for $f_{R0} = 5 \times 10^{-5}$ and $f_{R0} = 5 \times 10^{-7}$ and show that in the optimistic scenario, $\textit{Euclid}$ will be able to distinguish these models from $\Lambda\mathrm{CDM}$ at more than 3$\sigma$. (abridged), Comment: 10 Figures, 3 Tables, 1 Appendix
Published: 2023

39. Type Isomorphisms for Multiplicative-Additive Linear Logic

Author: Guardia, Rémi, Laurent, Olivier, Preuves et Langages (PLUME), Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), Marco Gaboardi, Femke van Raamsdonk, ANR-10-LABX-0070,MILYON,Community of mathematics and fundamental computer science in Lyon(2010), ANR-11-IDEX-0007,Avenir L.S.E.,PROJET AVENIR LYON SAINT-ETIENNE(2011), ANR-19-CE48-0010,DYVERSE,Sémantique Dynamique Versatile(2019), ANR-21-CE48-0019,RECIPROG,Raisonner avec des preuves circulaires pour la programmation(2021), and ANR-20-CE48-0005,QuaReMe,Méthodes de raisonnement quantitative pour les logiques probabilistiques(2020)
Subjects: Type Isomorphisms, Theory of computation → Linear logic, Star-autonomous categories with finite products, Proof nets, [INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO], Multiplicative-Additive fragment, Linear Logic, Sequent calculus
Abstract: We characterize type isomorphisms in the multiplicative-additive fragment of linear logic (MALL), and thus for ⋆-autonomous categories with finite products, extending a result for the multiplicative fragment by Balat and Di Cosmo [Vincent Balat and Roberto Di Cosmo, 1999]. This yields a much richer equational theory involving distributivity and annihilation laws. The unit-free case is obtained by relying on the proof-net syntax introduced by Hughes and Van Glabbeek [Dominic Hughes and Rob van Glabbeek, 2005]. We then use the sequent calculus to extend our results to full MALL (including all units)., LIPIcs, Vol. 260, 8th International Conference on Formal Structures for Computation and Deduction (FSCD 2023), pages 26:1-26:21
Published: 2023

40. Holonomic equations and efficient random generation of binary trees

Author: Lescanne, Pierre, Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), and École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL)
Subjects: FOS: Computer and information sciences, [INFO.INFO-CC]Computer Science [cs]/Computational Complexity [cs.CC], binary tree, Mathematics::Combinatorics, [INFO.INFO-DS]Computer Science [cs]/Data Structures and Algorithms [cs.DS], random generation, Computational Complexity (cs.CC), Computer Science - Computational Complexity, Catalan number, Motzkin number, Schroeder number, combinatorics, Computer Science - Data Structures and Algorithms, Data Structures and Algorithms (cs.DS), combinatorics random generation Motzkin number Catalan number binary tree unary-binary tree, unary-binary tree
Abstract: Holonomic equations are recursive equations which allow computingefficiently numbers of combinatoric objects. R{\'e}my showed that theholonomic equation associated with binary trees yields an efficientlinear random generator of binary trees. I extend this paradigm toMotzkin trees and Schr{\"o}der trees and show that despite slightdifferences my algorithm that generates random Schr{\"o}der trees has linearexpected complexity and my algorithm that generates Motzkin trees is inO(n) expected complexity, only if we can implement a specific oraclewith a O(1) complexity. For Motzkin trees, I propose a solution whichworks well for realistic values (up to size ten millions) and yields anefficient algorithm.
Published: 2023

41. Hexagonal Ge on self-assisted GaAs Nanowires for light emission

Author: Dudko, Iuliia, Dursap, Thomas, Lamirand, Anne, Botella, Claude, Regreny, Philippe, Danescu, Alexandre, Brottet, Solène, Bugnet, Matthieu, Walia, Sumeet, Chauvin, Nicolas, Penuelas, Jose, INL - Matériaux Fonctionnels et Nanostructures (INL - MFN), Institut des Nanotechnologies de Lyon (INL), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Royal Melbourne Institute of Technology University (RMIT University), INL - Plateforme Technologique Nanolyon (INL - Nanolyon), Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), GdR MatÉpi, ANR-10-LABX-0064,Imust,Institut for Multiscale Science and Technology : from Fundamental Physics and Chemistry to Engineering in New Material and Processes and Ecotechnologies(2010), ANR-17-CE30-0014,HEXSIGE,Propriétés de la phase hexagonale 2H du Ge et Si(2017), and European Project: ECLAUSion
Subjects: Hexagonal Germanium, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], Molecular Beam Epitaxy, Semiconductor Nanowires
Abstract: National audience
Published: 2023

42. How chitosan can be considered as a promising eco-efficient candidate to replace commercial organic-based resists in the photolithography process. Focus on photopatterning and etching behavior in fluorinated plasmas

Author: Léonard, Didier, Durin, Paule, Sysova, Olha, Guan, Yue, GABLIN, CORINNE, Benamrouche, Aziz, Hajjar-Garreau, Samar, Téolis, Alexandre, Trombotto, Stéphane, Delair, Thierry, Servin, Isabelle, Tiron, Raluca, Bazin, Arnaud, Berling, Dominique, Soppera, Olivier, Gehin, Thomas, Laurenceau, Emmanuelle, Leclercq, Jean -Louis, Chevolot, Yann, Surfaces, Institut des Sciences Analytiques (ISA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), INL - Dispositifs pour la Santé et l’Environnement (INL - DSE), Institut des Nanotechnologies de Lyon (INL), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Institut de Science des Matériaux de Mulhouse (IS2M), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), INL - Plateforme Technologique Nanolyon (INL - Nanolyon), Ingénierie des Matériaux Polymères (IMP), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), INL - Chimie et Nanobiotechnologies (INL - C&N), and ANR-19-CE43-0009,Lithogreen,Développement de polymères issus de la biomasse pour les procédés de micro et nanofabrication écoresponsables en milieu aqueux(2019)
Subjects: [SPI]Engineering Sciences [physics], [CHIM]Chemical Sciences
Abstract: International audience
Published: 2023

43. Nano objects evaluation for nanoparticle enhanced laser induced breakdown spectroscopy analysis of polymers using a handheld device

Author: Jad Sahili, Tessa Reinert, Nadia Baskali-Bouregaa, Anthony Desert, Nicole Gilon, Plasma spectroscopies, hyphenated methods & speciation, Institut des Sciences Analytiques (ISA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie de l’ENS Lyon, Ecole Normale Supérieure de Lyon, Laboratoire de Chimie - UMR5182 (LC), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), and ICL Lyon
Subjects: [CHIM]Chemical Sciences, Instrumentation, Spectroscopy, Atomic and Molecular Physics, and Optics, Analytical Chemistry
Abstract: International audience; Polymer additives are essential to provide essential properties to the plastic materials. Some of the mainly employed additives contain metals essential to measure like Sb, Pb or P. Laser Induced Breakdown Spectroscopy suffers a lack of sensitivity for these elements and especially when using handheld devices. The recent developments in Nanoparticles Enhanced Laser Induced Breakdown Spectroscopy (NELIBS) have led to improvement of signals mainly in conductive materials. In this work we prepared and evaluate nano-objects with different shapes and size to improve element signals on plastic samples. Ellipsoid, bipyramids and spheres increased significantly sensitivity of most additives i.e. P, Sb, Mg and Pb. The obtained gold ellipsoids nano-objects were of small dimensions and gave best signal enhancement. The NELIBS also increased the CaF molecular band signal by a factor of 2. These results indicate that the NELIBS can be used in quantitative analytical application for plastics even for difficult elements like fluorine.
Published: 2023

44. Scheduling Variable Capacity Resources for Sustainability Workshop

Author: Benoit, Anne, Chien, Andrew, Robert, Yves, Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), Optimisation des ressources : modèles, algorithmes et ordonnancement (ROMA), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Lyon, Institut National de Recherche en Informatique et en Automatique (Inria), University of Chicago, University of Chicago under the 'France And Chicago Collaborating in The Sciences' program, and ROMA (INRIA Rhône-Alpes / LIP Laboratoire de l’Informatique du Parallélisme)
Subjects: [INFO]Computer Science [cs]
Abstract: We gathered the research community focused on compute scheduling in the new age of renewable power generation -- where variation in weather and solar radiation drives renewable generation, and thereby the carbon-intensity of power, and efforts to reduce environmental damage then create variation in compute capacity (opportunity). In this age, effective utilization of that opportunity is the key to sustainable computing. We report important findings on the attributes of future platforms, characterizing the power grid variation, reliability challenges, and two-way relationships between datacenters and grid that are emerging. Workloads are changing as well, with growing understanding of how computing can be malleable, delay flexible, or even acceptably approximate. Between these, we focus on how scheduling can meet these challenges, managing between flexible workloads and dynamically varying platforms – performing to new metrics that reflect both performance and non-performance attributes (e.g. carbon emissions). The concerns that underlie a shift to variable capacity derive from a broader societal concern about the sustainability of computing, and our last section addresses critical challenges in awareness, responsibilities, and action.The talks and position papers from attendees are available at https://people.cs.uchicago.edu/~aachien/workshops/varsched23/.
Published: 2023

45. Investigating the Long-term Effect of Pregnancy on the Course of Multiple Sclerosis Using Causal Inference

Author: Gavoille, Antoine, Rollot, Fabien, Casey, Romain, Debouverie, Marc, Le Page, Emmanuelle, Ciron, Jonathan, de Seze, Jerome, Ruet, Aurélie, Maillart, Elisabeth, Labauge, Pierre, Zephir, Helene, Papeix, Caroline, Defer, Gilles, Lebrun-Frenay, Christine, Moreau, Thibault, Laplaud, David Axel, Berger, Eric, Stankoff, Bruno, Clavelou, Pierre, Thouvenot, Eric, Heinzlef, Olivier, Pelletier, Jean, Al Khedr, Abdullatif, Casez, Olivier, Bourre, Bertrand, Cabre, Philippe, Wahab, Abir, Magy, Laurent, Camdessanche, Jean-Philippe, Maurousset, Aude, Moulin, Solène, Ben, Nasr Haifa, Boulos, Dalia Dimitri, Hankiewicz, Karolina, Neau, Jean-Philippe, Pottier, Corinne, Nifle, Chantal, Rabilloud, Muriel, Subtil, Fabien, Vukusic, Sandra, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Laboratoire d'Immunologie (EA 2686), Université de Lille, Droit et Santé, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Neurologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CIC Plurithématique de Nantes, Institut National de la Santé et de la Recherche Médicale (INSERM)-Ministère des Affaires sociales et de la Santé-Direction générale de l'offre de soins (DGOS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Barcelona Supercomputing Center - Centro Nacional de Supercomputacion (BSC - CNS), CHU Saint-Antoine [AP-HP], Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), CHI Poissy-Saint-Germain, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], and Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL)
Subjects: MESH: Humans, MESH: Multiple Sclerosis, Relapsing-Remitting, MESH: Probability, All CBMRT/Null Hypothesis, MESH: Multiple Sclerosis, MESH: Disabled Persons, MESH: Recurrence, Multiple sclerosis, MESH: Pregnancy, Cohort studies, MESH: Disease Progression, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), MESH: Female, MESH: Cohort Studies, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Research Article
Abstract: Background and ObjectivesThe question of the long-term safety of pregnancy is a major concern in patients with multiple sclerosis (MS), but its study is biased by reverse causation (women with higher disability are less likely to experience pregnancy). Using a causal inference approach, we aimed to estimate the unbiased long-term effects of pregnancy on disability and relapse risk in patients with MS and secondarily the short-term effects (during the perpartum and postpartum years) and delayed effects (occurring beyond 1 year after delivery).MethodsWe conducted an observational cohort study with data from patients with MS followed in the Observatoire Français de la Sclérose en Plaques registry between 1990 and 2020. We included female patients with MS aged 18–45 years at MS onset, clinically followed up for more than 2 years, and with ≥3 Expanded Disease Status Scale (EDSS) measurements. Outcomes were the mean EDSS score at the end of follow-up and the annual probability of relapse during follow-up. Counterfactual outcomes were predicted using the longitudinal targeted maximum likelihood estimator in the entire study population. The patients exposed to at least 1 pregnancy during their follow-up were compared with the counterfactual situation in which, contrary to what was observed, they would not have been exposed to any pregnancy. Short-term and delayed effects were analyzed from the first pregnancy of early-exposed patients (who experienced it during their first 3 years of follow-up).ResultsWe included 9,100 patients, with a median follow-up duration of 7.8 years, of whom 2,125 (23.4%) patients were exposed to at least 1 pregnancy. Pregnancy had no significant long-term causal effect on the mean EDSS score at 9 years (causal mean difference [95% CI] = 0.00 [−0.16 to 0.15]) or on the annual probability of relapse (causal risk ratio [95% CI] = 0.95 [0.93–1.38]). For the 1,253 early-exposed patients, pregnancy significantly decreased the probability of relapse during the perpartum year and significantly increased it during the postpartum year, but no significant delayed effect was found on the EDSS and relapse rate.DiscussionUsing a causal inference approach, we found no evidence of significantly deleterious or beneficial long-term effects of pregnancy on disability. The beneficial effects found in other studies were probably related to a reverse causation bias.
Published: 2022

46. Better safe than sorry: Macroprudential policy, Covid 19 and climate change

Author: Gaëtan Le Quang, Laurence Scialom, EconomiX, Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS), Groupe d'analyse et de théorie économique (GATE Lyon Saint-Étienne), École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne (GATE Lyon Saint-Étienne), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 050208 finance, Climate risk, As is, media_common.quotation_subject, 05 social sciences, Financial market, Climate change, Financial system, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Discount points, General Business, Management and Accounting, Macroprudential regulation, Financial regulation, State (polity), [No keyword available], 0502 economics and business, Economics, 050207 economics, General Economics, Econometrics and Finance, ComputingMilieux_MISCELLANEOUS, media_common
Abstract: The crisis of 2007-08 called for a renewal of banking regulation that took the shape of a shift toward macroprudential policy. However, a comprehensive assessment of the current state of financial regulation reveals that this shift is incomplete. In particular, the notion of risk that lies at the heart of the Basel framework is still blind to extreme events. Climate risk and pandemic risk fall into this category. The purpose of this article is twofold. On the one hand, we point out why current banking regulation is not adequate to face risks whose origin is grounded outside financial markets – as is the case for both the pandemic and the climate risks –; on the other hand, we offer avenues for reforming macroprudential regulation in a way that would allow to take those risks into account.
Published: 2022

47. In vivo targeting and multimodal imaging of cerebral amyloid-β aggregates using hybrid GdF3 nanoparticles

Author: Frédéric Lerouge, Elodie Ong, Hugo Rositi, Francis Mpambani, Lise-Prune Berner, Radu Bolbos, Cécile Olivier, Françoise Peyrin, Vinu K Apputukan, Cyrille Monnereau, Chantal Andraud, Frederic Chaput, Yves Berthezène, Bettina Braun, Mathias Jucker, Andreas KO Åslund, Sofie Nyström, Per Hammarström, K Peter R Nilsson, Mikael Lindgren, Marlène Wiart, Fabien Chauveau, Stephane Parola, Laboratoire de Chimie - UMR5182 (LC), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hospices Civils de Lyon (HCL), Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Linköping University (LIU), Norwegian University of Science and Technology (NTNU), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ANR-15-CE18-0026,NanoBrain,Imagerie de l'inflammation cérébrale dans l'AVC ischémique : développement d'une sonde nanoparticulaire multimodale & méthodes d'imagerie cérébrale(2015), and European Project: 242098,EC:FP7:HEALTH,FP7-HEALTH-2009-single-stage,LUPAS(2009)
Subjects: [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Biomedical Engineering, Medicine (miscellaneous), multimodal imaging, General Materials Science, Bioengineering, luminescent-conjugated polythiophenes, Development, gadolinium fluoride nanoparticles, amyloid-beta
Abstract: Aim: To propose a new multimodal imaging agent targeting amyloid-β (Aβ) plaques in Alzheimer’s disease. Materials & methods: A new generation of hybrid contrast agents, based on gadolinium fluoride nanoparticles grafted with a pentameric luminescent-conjugated polythiophene, was designed, extensively characterized and evaluated in animal models of Alzheimer’s disease through MRI, two-photon microscopy and synchrotron x-ray phase-contrast imaging. Results & conclusion: Two different grafting densities of luminescent-conjugated polythiophene were achieved while preserving colloidal stability and fluorescent properties, and without affecting biodistribution. In vivo brain uptake was dependent on the blood–brain barrier status. Nevertheless, multimodal imaging showed successful Aβ targeting in both transgenic mice and Aβ fibril-injected rats.
Published: 2022

48. Mechanical stress driven by rigidity sensing governs epithelial stability

Author: Surabhi Sonam, Lakshmi Balasubramaniam, Shao-Zhen Lin, Ying Ming Yow Ivan, Irina Pi-Jaumà, Cecile Jebane, Marc Karnat, Yusuke Toyama, Philippe Marcq, Jacques Prost, René-Marc Mège, Jean-François Rupprecht, Benoît Ladoux, Institut Jacques Monod (IJM (UMR_7592)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre de Physique Théorique - UMR 7332 (CPT), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), CPT - E5 Physique statistique et systèmes complexes, Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Mechanobiology Institute [Singapore] (MBI), National University of Singapore (NUS), Sorbonne Université - Faculté de Physique (UFR 925), Sorbonne Université (SU), Procédés et Mécanique des Matériaux (PMM), Institut de Recherche en Génie Civil et Mécanique (GeM), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Nantes (Nantes Univ - ECN), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université - Institut Universitaire de Technologie Saint-Nazaire (Nantes Univ - IUT Saint-Nazaire), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - Ecole Polytechnique de l'Université de Nantes (Nantes Univ - EPUN), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Nantes (Nantes Univ - ECN), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), ANR-16-CONV-0001,CENTURI,CenTuri : Centre Turing des Systèmes vivants(2016), ANR-17-CE13-0012,MecanoAdipo,Mécanotransduction des cellules souches adipeuses et applications pour l'ingénierie tissulaire(2017), ANR-20-CE30-0023,COVFEFE,Hydrodynamique Covariante, Fluctuante et Active des Ecoulements Epithéliaux(2020), ANR-19-CE13-0016,MyoFuse,Contrôle génétique et mécanique de la fusion des myoblastes(2019), Biophysique (BIOPHYSIQUE), Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratoire Physico-Chimie Curie [Institut Curie] (PCC), and Institut Curie [Paris]-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [PHYS]Physics [physics], [SDV]Life Sciences [q-bio], General Physics and Astronomy, [SDV.BC]Life Sciences [q-bio]/Cellular Biology
Abstract: Epithelia act as a barrier against environmental stress and abrasion and in vivo they are continuously exposed to environments of various mechanical properties. The impact of this environment on epithelial integrity remains elusive. By culturing epithelial cells on 2D hydrogels, we observe a loss of epithelial monolayer integrity through spontaneous hole formation when grown on soft substrates. Substrate stiffness triggers an unanticipated mechanical switch of epithelial monolayers from tensile on soft to compressive on stiff substrates. Through active nematic modelling, we find unique patterns of cell shape texture called nematic topological defects that underpin large isotropic stress fluctuations at certain locations thereby triggering mechanical failure of the monolayer and hole opening. Our results show that substrate stiffness provides feedback on monolayer mechanical state and that topological defects can trigger stochastic mechanical failure, with potential application towards a mechanistic understanding of compromised epithelial integrity in bacterial infection, tumor progression and morphogenesis.
Published: 2022

49. Theoretical Analysis of Physical and Chemical CO2 Absorption by Tri- and Tetraepoxidized Imidazolium Ionic Liquids

Author: Luke Wylie, Gabriel Perli, Jocasta Avila, Sebastien Livi, Jannick Duchet-Rumeau, Margarida Costa Gomes, Agilio Padua, Laboratoire de Chimie - UMR5182 (LC), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Ingénierie des Matériaux Polymères (IMP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA), Breakthrough program 4D-IOLIMAT, and ANR-16-IDEX-0005,IDEXLYON,IDEXLYON(2016)
Subjects: Materials Chemistry, Physical and Theoretical Chemistry, [CHIM.CHEM]Chemical Sciences/Cheminformatics, Surfaces, Coatings and Films
Abstract: International audience; The efficient capture of CO2 from flue gas ordirectly from the atmosphere is a key subject to mitigate globalwarming, with several chemical and physical absorption methodspreviously reported. Through polarizable molecular dynamics(MD) simulations and high-level quantum chemical (QC)calculations, the physical and chemical absorption of CO2 byionic liquids based on imidazolium cations bearing oxirane groupswas investigated. The ability of the imidazolium group to absorbCO2 was found to be prevalent in both the tri- and tetraepoxidizedimidazolium ionic liquids (ILs) with coordination numbers over 2for CO2 within the first solvation shell in both systems.Thermodynamic analysis of the addition of CO2 to convertepoxy groups to cyclic carbonates also indicated that the overall reaction is exergonic for all systems tested, allowing for chemicalabsorption of CO2 to also be favored. The rate-determining step of the chemical absorption involved the initial opening of the epoxyring through addition of the chloride anion and was seen to vary greatly between the epoxy groups tested. Among the groups tested,the less sterically hindered monoepoxy side of the triepoxidized imidazolium was shown to be uniquely capable of undergoingintramolecular hydrogen bonding and thus lowering the barrier required for the intermediate structure to form during the reaction.Overall, this theoretical investigation highlights the potential for epoxidized imidazolium chloride ionic liquids for simultaneouschemical and physical absorption of CO2.
Published: 2022

50. Critical Role of Water on the Synthesis and Gelling of γ-In2S3 Nanoribbons with a Giant Aspect Ratio

Author: Guillemeney, Lilian, Lermusiaux, Laurent, Davidson, Patrick, Hubley, Austin, Pierini, Stefano, Pierucci, Debora, Patriarche, Gilles, Canut, Bruno, Lhuillier, Emmanuel, Mahler, Benoît, Abécassis, Benjamin, Laboratoire de Chimie - UMR5182 (LC), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des Solides (LPS), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Luminescence (LUMINESCENCE), Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Department of Science and Technology, Parthenope University of Naples, Naples, Italy, Centre de Nanosciences et de Nanotechnologies (C2N), INL - Matériaux Fonctionnels et Nanostructures (INL - MFN), Institut des Nanotechnologies de Lyon (INL), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Physico-chimie et dynamique des surfaces (INSP-E6), Institut des Nanosciences de Paris (INSP), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), and European Project: 865995,SENECA
Subjects: General Chemical Engineering, Materials Chemistry, [CHIM]Chemical Sciences, General Chemistry
Abstract: International audience
Published: 2022

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