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261 results on '"Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)"'

1. Continuité sur les espaces de tentes par extrapolation

Author: Auscher, Pascal, Prisuelos-Arribas, Cruz, Laboratoire de Mathématiques d'Orsay (LM-Orsay), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), Instituto de Ciencias Matemáticas (ICMAT), Universidad Carlos III de Madrid [Madrid] (UC3M)-Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), ANR-12-BS01-0013,HAB,Aux frontières de l'analyse Harmonique(2012), and Universidad Carlos III de Madrid [Madrid] (UC3M)-Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM)-Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: tent spaces, Mathematics::Functional Analysis, atoms, 42B20,42B25,42B35,47B34, Mathematics::Classical Analysis and ODEs, extrapolation, singular integrals, [MATH.MATH-CA]Mathematics [math]/Classical Analysis and ODEs [math.CA], [MATH.MATH-FA]Mathematics [math]/Functional Analysis [math.FA], amalgalm spaces, maximal operators
Abstract: International audience; We study the action of operators on tent spaces such as maximal operators, Calderón-Zygmund operators, Riesz potentials. We also consider singular non-integral operators. We obtain boundedness as an application of extrapolation methods in the Banach range. In the non Banach range, boundedness results for Calderón-Zygmund operators follows by using an appropriate atomic theory. We end with some consequences on amalgalm spaces.
Published: 2017

2. Large scale genomic reorganization of topological domains at the HoxD locus

Author: Daan Noordermeer, Pierre J. Fabre, Lucille Lopez-Delisle, Benjamin H. Mormann, Leonardo Beccari, Marion Leleu, Denis Duboule, School of Life Sciences [Lausanne], Ecole Polytechnique Fédérale de Lausanne (EPFL), Unité de génétique et biologie des cancers (U830), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Dynamique de la Chromatine (CHRODY), Département Biologie des Génomes (DBG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Neurobiologia Molecular Celular y del desarrollo, Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Autonoma de Madrid (UAM)-CIBER de Enfermedades Raras (CIBERER), Chaire internationale Évolution des génomes et développement, Collège de France (CdF (institution)), Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-CIBER de Enfermedades Raras (CIBERER), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-Institut de Biologie Intégrative de la Cellule (I2BC), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Centro de Biologia Molecular Severo Ochoa (CBMSO)-CIBER de Enfermedades Raras (CIBERER), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-CIBER de Enfermedades Raras (CIBERER), and Collège de France - Chaire internationale Évolution des génomes et développement
Subjects: 0301 basic medicine, Chromatin Immunoprecipitation, Genomic Islands, Transcription, Genetic, lcsh:QH426-470, [SDV]Life Sciences [q-bio], Locus (genetics), Regulatory Sequences, Nucleic Acid, Biology, Topology, Chromosome conformation capture, Mice, 03 medical and health sciences, Chromatin organization, Animals, Hox gene, Enhancer, lcsh:QH301-705.5, In Situ Hybridization, Fluorescence, Limb development, Gene Rearrangement, Topologically associating domains, Research, Genes, Homeobox, High-Throughput Nucleotide Sequencing, Genomics, TAD, Gene rearrangement, CTCF, Hox, Gene regulation, Chromatin, lcsh:Genetics, Enhancer Elements, Genetic, 030104 developmental biology, lcsh:Biology (General), Genetic Loci, Multigene Family, Chromatin immunoprecipitation, Regulatory landscape
Abstract: Background The transcriptional activation of HoxD genes during mammalian limb development involves dynamic interactions with two topologically associating domains (TADs) flanking the HoxD cluster. In particular, the activation of the most posterior HoxD genes in developing digits is controlled by regulatory elements located in the centromeric TAD (C-DOM) through long-range contacts. Results To assess the structure–function relationships underlying such interactions, we measured compaction levels and TAD discreteness using a combination of chromosome conformation capture (4C-seq) and DNA FISH. We assessed the robustness of the TAD architecture by using a series of genomic deletions and inversions that impact the integrity of this chromatin domain and that remodel long-range contacts. We report multi-partite associations between HoxD genes and up to three enhancers. We find that the loss of native chromatin topology leads to the remodeling of TAD structure following distinct parameters. Conclusions Our results reveal that the recomposition of TAD architectures after large genomic re-arrangements is dependent on a boundary-selection mechanism in which CTCF mediates the gating of long-range contacts in combination with genomic distance and sequence specificity. Accordingly, the building of a recomposed TAD at this locus depends on distinct functional and constitutive parameters. Electronic supplementary material The online version of this article (doi:10.1186/s13059-017-1278-z) contains supplementary material, which is available to authorized users.
Published: 2017
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3. De Novo Mutations in SLC25A24 Cause a Disorder Characterized by Early Aging, Bone Dysplasia, Characteristic Face, and Early Demise

Author: Raoul C.M. Hennekam, Lidija Kovačič, Marco Castori, Karin Writzl, Laura Contreras, Borut Peterlin, Pablo Lapunzina, Jorgina Satrústegui, André B.P. van Kuilenburg, Aleš Maver, Laurence Faivre, Christel Thauvin-Robinet, Paula Martínez-Valero, Araceli del Arco, Slobodanka Radovic, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA -Cancer Center Amsterdam, Laboratory Genetic Metabolic Diseases, APH - Quality of Care, Paediatric Genetics, Clinical Institute of Medical Genetics (University Medical Centre, Slovenia), University Medical Centre Slovenia, Novartis Ireland Ltd. (Dublin), Instituto de Investigación Sanitaria Fundación Jiménez Diaz (Madrid), Centro de Diagnóstico de Enfermedades Moleculares, Dpto. Biol. Mol. Centro de Biología Molecular-SO UAM-CSIC. Universidad Autónoma Madrid, Campus Cantoblanco, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Car, Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa (Universidad Autónoma de Madrid and Consejo Superior de Investigaciones Científicas), Instituto de Investigaciones Biomédicas Alberto Sols [Madrid, Spain] (IIBM), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Department of Genetics, Centre de génétique - Centre de référence des maladies rares, anomalies du développement et syndromes malformatifs (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Equipe GAD (LNC - U1231), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, INGEMM, Instituto de Genética Médica y Molecular, IDIPAZ-Hospital Universitario La Paz, Laboratory Genetic Metabolic Diseases, Academic Medical Center at the University of Amsterdam, (AMC), Universiteit van Amsterdam (UvA), IGA Technology Services Srl. (Udine), Centro de Biología Molecular Severo Ochoa (CBMSO), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Department of Pediatrics, Academic Medical Center, University of Amsterdam, Instituto de Investigación Sanitaria Fundación Jiménez Diaz [Madrid] (IIS-FJD), Universidad Autonoma de Madrid (UAM)-Fundacion Jimenez Diaz [Madrid] (FJD), Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Lipides - Nutrition - Cancer [Dijon - U1231] ( LNC ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Laboratory Genetic Metabolic Diseases, Academic Medical Center at the University of Amsterdam, ( AMC ), Université d'Amsterdam, Centro de Biología Molecular Severo Ochoa ( CBMSO ), Universidad Autonoma de Madrid ( UAM ) -Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), and Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, 0301 basic medicine, Aging, Mitochondrion, Petty syndrome, Antiporters, ATP-Mg/Pi carriers, Adenosine Triphosphate, Cytosol, 0302 clinical medicine, Adenine nucleotide, Missense mutation, [ SDV.GEN.GH ] Life Sciences [q-bio]/Genetics/Human genetics, Genetics (clinical), Exome sequencing, Membrane Potential, Mitochondrial, Genetics, Progeria, ATP synthase, SCaMC-1, Syndrome, Mitochondria, 3. Good health, Female, medicine.medical_specialty, lipodystrophy, Molecular Dynamics Simulation, Biology, Phosphates, Mitochondrial Proteins, 03 medical and health sciences, Report, Internal medicine, medicine, Humans, Fetal Death, Bone Diseases, Developmental, Adenine, SLC25A24, Calcium-Binding Proteins, aging, Infant, Newborn, Infant, progeria, Fibroblasts, medicine.disease, Mitochondrial carrier, Solute carrier family, Oxygen, progeroid disorder, 030104 developmental biology, Endocrinology, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Mutation, biology.protein, 030217 neurology & neurosurgery
Abstract: International audience; A series of simplex cases have been reported under various diagnoses sharing early aging, especially evident in congenitally decreased subcutaneous fat tissue and sparse hair, bone dysplasia of the skull and fingers, a distinctive facial gestalt, and prenatal and postnatal growth retardation. For historical reasons, we suggest naming the entity Fontaine syndrome. Exome sequencing of four unrelated affected individuals showed that all carried the de novo missense variant c.649C>T (p.Arg217Cys) or c.650G>A (p.Arg217His) in SLC25A24, a solute carrier 25 family member coding for calcium-binding mitochondrial carrier protein (SCaMC-1, also known as SLC25A24). SLC25A24 allows an electro-neutral and reversible exchange of ATP-Mg and phosphate between the cytosol and mitochondria, which is required for maintaining optimal adenine nucleotide levels in the mitochondrial matrix. Molecular dynamic simulation studies predict that p.Arg217Cys and p.Arg217His narrow the substrate cavity of the protein and disrupt transporter dynamics. SLC25A24-mutant fibroblasts and cells expressing p.Arg217Cys or p.Arg217His variants showed altered mitochondrial morphology, a decreased proliferation rate, increased mitochondrial membrane potential, and decreased ATP-linked mitochondrial oxygen consumption. The results suggest that the SLC25A24 mutations lead to impaired mitochondrial ATP synthesis and cause hyperpolarization and increased proton leak in association with an impaired energy metabolism. Our findings identify SLC25A24 mutations affecting codon 217 as the underlying genetic cause of human progeroid Fontaine syndrome.
Published: 2017

4. The Transcription Factor Encyclopedia

Author: Yusuf, Dimas, Butland, Stefanie L., Swanson, Magdalena I., Bolotin, Eugene, Ticoll, Amy, Cheung, Warren A., Zhang, Xiao Yu Cindy, Dickman, Christopher T. D., Fulton, Debra L., Lim, Jonathan S., Schnabl, Jake M., Ramos, Oscar H. P., Vasseur-Cognet, Mireille, de Leeuw, Charles N., Simpson, Elizabeth M., Ryffel, Gerhart U., Lam, Eric W.-F., Kist, Ralf, Wilson, Miranda S. C., Marco-Ferreres, Raquel, Brosens, Jan J., Beccari, Leonardo L., Bovolenta, Paola, Benayoun, Bérénice A., Monteiro, Lara J, Schwenen, Helma D C, Grontved, Lars, Wederell, Elizabeth, Mandrup, Susanne, Veitia, Reiner A, Chakravarthy, Harini, Hoodless, Pamela A., Mancarelli, M Michela, Torbett, Bruce E, Banham, Alison H, Reddy, Sekhar P, Cullum, Rebecca L, Liedtke, Michaela, Tschan, Mario P, Vaz, Michelle, Rizzino, Angie, Zannini, Mariastella, Frietze, Seth, Farnham, Peggy J, Eijkelenboom, Astrid, Brown, Philip J, Laperrière, David, Leprince, Dominique, de Cristofaro, Tiziana, Prince, Kelly L, Putker, Marrit, del Peso, Luis, Camenisch, Gieri, Wenger, Roland H, Mikula, Michal, Rozendaal, Marieke, Mader, Sylvie, Ostrowski, Jerzy, Rhodes, Simon J, Van Rechem, Capucine, Boulay, Gaylor, Olechnowicz, Sam W Z, Breslin, Mary B, Lan, Michael S, Nanan, Kyster K, Wegner, Michael, Hou, Juan, Mullen, Rachel D, Colvin, Stephanie C, Noy, Peter John, Webb, Carol F, Witek, Matthew E, Ferrell, Scott, Daniel, Juliet M, Park, Jason, Waldman, Scott A, Peet, Daniel J, Taggart, Michael, Jayaraman, Padma-Sheela, Karrich, Julien J, Blom, Bianca, Vesuna, Farhad, O'Geen, Henriette, Sun, Yunfu, Gronostajski, Richard M, Woodcroft, Mark W, Hough, Margaret R, Chen, Edwin, Europe-Finner, G Nicholas, Karolczak-Bayatti, Magdalena, Bailey, Jarrod, Hankinson, Oliver, Raman, Venu, LeBrun, David P, Biswal, Shyam, Harvey, Christopher J, DeBruyne, Jason P, Hogenesch, John B, Hevner, Robert F, Héligon, Christophe, Luo, Xin M, Blank, Marissa Cathleen, Millen, Kathleen Joyce, Sharlin, David S, Forrest, Douglas, Dahlman-Wright, Karin, Zhao, Chunyan, Mishima, Yuriko, Sinha, Satrajit, Chakrabarti, Rumela, Portales-Casamar, Elodie, Sladek, Frances M, Bradley, Philip H, Wasserman, Wyeth W, Cindy Zhang, Xiao, Department of Medical Genetics, Faculty of Medicine-Child and Family Research Institute-Centre for Molecular Medicine and Therapeutics-University of British Columbia (UBC), Evaluation and Research Services, Fraser Health Authority, Children's Hospital Oakland, Oakland Research Institute, Computational Biology Program, Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Department of Bioinformatics, Child and Family Research Institute-Centre for Molecular Medicine and Therapeutics-University of British Columbia (UBC), Department of Biology, University of Western Ontario (UWO), Genetics Program, Department of Cell Biology and Neuroscience [Riverside] (CBNS), University of California [Riverside] (UC Riverside), University of California (UC)-University of California (UC), Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) (SIMoS), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut für Zellbiologie, Universität Duisburg-Essen [Essen]-Universitätsklinikum Essen, Department of Surgery and Cancer, Imperial College London-Division of Cancer, Centre for Oral Health Research, Newcastle University [Newcastle]-Medical School-School of Dental Sciences, Department of Development and Differentiation, Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-CIBER de Enfermedades Raras (CIBERER), Division of Reproductive Health, University of Warwick [Coventry]-Warwick Medical School, University of Warwick [Coventry], Neurobiologia Molecular Celular y del desarrollo, Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Department of Biochemistry and Molecular Biology, University of Southern Denmark (SDU), Terry Fox Laboratory, BC Cancer Agency (BCCRC)-Provincial Health Services Authority, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, University of Nebraska System-University of Nebraska System, Department of Molecular Experimental Medicine, The Scripps Research Institute [La Jolla, San Diego], Departments of Molecular and Experimental Medicine and Immunology and Microbial Sciences (MEM 131), Nuffield Department of Clinical Laboratory Sciences, University of Oxford- John Radcliffe Hospital [Oxford University Hospital]-Oxford NIHR Biomedical Research Centre, Department of Pediatrics, College of Medicine-Department of pediatrics-University of Illinois [Chicago] (UIC), University of Illinois System-University of Illinois System, Division of Hematology [Stanford], Stanford Medicine, Stanford University-Stanford University, Department of Medicine, University of Bern, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine [Baltimore]-Johns Hopkins University School of Medicine [Baltimore]-Johns Hopkins University School of Medicine, Institute of Experimental Endocrinology and Oncology (IEOS), Consiglio Nazionale delle Ricerche (CNR), University of Southern California (USC)-Norris Comprehensive Cancer Center, Department of Molecular Cancer Research, University Medical Center [Utrecht]-Utrecht University [Utrecht], University of Oxford- John Radcliffe Hospital [Oxford University Hospital]-Medical Sciences Division, Molecular Targeting in Breast Cancer research unit, Institut de Recherche en Immunologie et en Cancérologie [UdeM-Montréal] (IRIC), Université de Montréal (UdeM)-Université de Montréal (UdeM), Institut de biologie de Lille - IBL (IBLI), Université de Lille, Sciences et Technologies-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indiana University System-Indiana University System, Department of Physiological Chemistry, Department of Biochemistry, Universidad Autónoma de Madrid (UAM)-School of Medicine, Institute of Physiology, Universität Zürich [Zürich] = University of Zurich (UZH)-Zurich Center for Integrative Human Physiology, Department of Oncological Genetics, Institute of Oncology-Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (MCMCC)-Medical Center of Postgraduate Education [Warsaw] (MCPE), Indiana University [Bloomington], Indiana University System-Indiana University System-School of Science, Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston]-Cancer Center, University of Adelaide-School of Molecular and Biomedical Science, Department of Pediatrics and Biochemistry and Molecular Biology, Louisiana State University (LSU)-Research Institute for Children-Children's Hospital at New Orleans, Departments of Pediatrics and Genetics, Department of Pathology and Molecular Medicine, Queen's University [Kingston, Canada]-Queen's Cancer Research Institute, School of Medicine [Erlangen], Friedrich-Alexander Universität Erlangen-Nürnberg (FAU)-Institut fuer Biochemie-Emil-Fischer-Zentrum, Department of Molecular Biology and Biochemistry, University Indianapolis-Indiana University School of Medicine, Department of Immunity and Infection, School of Medical and Dental Sciences-University of Birmingham [Birmingham], Immunobiology and Cancer Program, Oklahoma Medical Research Foundation (OMRF), Radiation Oncology, Department of Pharmacology and Experimental Therapeutics-Jefferson University Hospitals, Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center (OUHSC), McMaster University [Hamilton, Ontario], School of Medicine, Johns Hopkins University (JHU), Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University-Jefferson Medical College, Discipline of Biochemistry, Institute of Cellular Medicine, Newcastle University [Newcastle]-Faculty of Medicine-Medical School, Department of Immunity and Immunology, Department of Cell Biology and Histology, Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA)-University of Amsterdam [Amsterdam] (UvA)-Center for Immunology Amsterdam, Division of Cancer Imaging Research, Johns Hopkins University (JHU)-School of Medicine-Department of Radiology, Genome Center [UC Davis], University of California [Davis] (UC Davis), School of Biological Sciences [Univ California San Diego] (UC San Diego), University of California [San Diego] (UC San Diego), Department of Biochemistry and Developmental Genomics Group, University at Buffalo [SUNY] (SUNY Buffalo), State University of New York (SUNY)-State University of New York (SUNY)-Center of Excellence in Bioinformatics and Life Sciences, Department of Molecular and Cellular Biology, University of Toronto-Sunnybrook Health Sciences Centre-Department of Laboratory Medicine and Pathobiology, Faculty of Medical Sciences, Newcastle University [Newcastle]-Medical School-Institute of Cellular Medicine, Department of Pathology and Laboratory Medicine, University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC)-David Geffen School of Medicine [Los Angeles], Radiology and Oncology, Johns Hopkins University (JHU)-School of Medicine, Department of Environmental Health Sciences, Johns Hopkins University (JHU)-Johns Hopkins Bloomberg School of Public Health [Baltimore], Department of Pharmacology and Toxicology, Neuroscience Institute-Morehouse School of Medicine, Department of Pharmacology, University of Pennsylvania-Perelman School of Medicine, University of Pennsylvania, Department of Neurological Surgery, University of Washington [Seattle]-Seattle Children's Research Institute, Faculty of Biology and Medicine, Université de Lausanne = University of Lausanne (UNIL)-Center for Integrated Genomics, Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University [Blacksburg]-Virginia-Maryland College of Veterinary Medicine, Department of Molecular Genetics and Cell Biology, University of Illinois [Chicago] (UIC), Center for Integrative Brain Research, University of Washington [Seattle], Clinical Endocrinology Branch, National Institutes of Health (NIH)-National Institute of Diabetes, Digestive, and Kidney Disorders, Department of Biosciences and Nutrition, Karolinska Institutet [Stockholm], State University of New York (SUNY)-State University of New York (SUNY), BMC, Ed., Universität Duisburg-Essen = University of Duisburg-Essen [Essen]-Universitätsklinikum Essen, National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), UAM. Departamento de Bioquímica, Faculty of Medicine-Child and Family Research Institute-Centre for Molecular Medicine and Therapeutics-University of British Columbia ( UBC ), Fred Hutchinson Cancer Research Center [Seattle] ( FHCRC ) -Public Health Sciences Division, Child and Family Research Institute-Centre for Molecular Medicine and Therapeutics-University of British Columbia ( UBC ), University of Western Ontario ( UWO ), Department of Cell Biology and Neuroscience [Riverside] ( CBNS ), University of California [Riverside] ( UCR ), Service d'Ingénierie Moléculaire des Protéines ( SIMOPRO ), Département Médicaments et Technologies pour la Santé ( DMTS ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Institut Cochin ( UM3 (UMR 8104 / U1016) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), CIBER de Enfermedades Raras (CIBERER)-Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ) -Centro de Biologia Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ) -Centro de Biologia Molecular Severo Ochoa (CBMSO)-CIBER de Enfermedades Raras (CIBERER), Service de Pathologies moléculaire et cellulaire, Institut Jacques Monod ( IJM ), Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), UNIVERSITY OF SOUTHERN DENMARK, BC Cancer Agency ( BCCRC ) -Provincial Health Services Authority, Scripps Research Institute, Departments of Molecular and Experimental Medicine and Immunology and Microbial Sciences ( MEM 131 ), University of Oxford [Oxford]- John Radcliffe Hospital [Oxford University Hospital]-Oxford NIHR Biomedical Research Centre, College of Medicine-Department of pediatrics-University of Illinois at Chicago ( UIC ), Department of Medicine/Hematology, Stanford University School of Medicine, Institute of Experimental Endocrinology and Oncology ( IEOS ), CNR - National Research Council, University of Southern California ( USC ) -Norris Comprehensive Cancer Center, Utrecht University [Utrecht]-University Medical Center Utrecht, University of Oxford [Oxford]- John Radcliffe Hospital [Oxford University Hospital]-Medical Sciences Division, Université de Montréal-Institute for Research in Immunology and Cancer, Institut de biologie de Lille - IBL ( IBLI ), Réseau International des Instituts Pasteur ( RIIP ) -Réseau International des Instituts Pasteur ( RIIP ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Lille, Droit et Santé, Utrecht University [Utrecht]-University Medical Centre Utrecht, Universidad Autonoma de Madrid ( UAM ) -School of Medicine, University of Zürich [Zürich] ( UZH ) -Zurich Center for Integrative Human Physiology, Institute of Oncology-Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology ( MCMCC ) -Medical Center of Postgraduate Education [Warsaw] ( MCPE ), Indiana University [Bloomington]-School of Science, Harvard Medical School [Boston] ( HMS ) -Cancer Center-Massachusetts General Hospital, Louisiana State University Health Sciences Center-Research Institute for Children-Children's Hospital at New Orleans, Queen's University [Kingston]-Queen's Cancer Research Institute, Institut fuer Biochemie-Emil-Fischer-Zentrum-Friedrich-Alexander Universitaet Erlangen-Nuernberg, Indiana University School of Medicine-University Indianapolis, Oklahoma Medical Research Foundation, Department of Pharmacology and Experimental Therapeutics-Jefferson University Hospital, University of Oklahoma Health Sciences Center ( OUHSC ), Johns Hopkins University ( JHU ), Academic Medical Center [Amsterdam] ( AMC ), University of Amsterdam [Amsterdam] ( UvA ) -University of Amsterdam [Amsterdam] ( UvA ) -Center for Immunology Amsterdam, Johns Hopkins University ( JHU ) -School of Medicine-Department of Radiology, University of California at Davis, Division of Biological Sciences [San Diego], University of California [San Diego] ( UC San Diego ), State University of New York at Buffalo ( SUNY Buffalo ) -Center of Excellence in Bioinformatics and Life Sciences, University of California at Los Angeles [Los Angeles] ( UCLA ) -David Geffen School of Medicine, Johns Hopkins University ( JHU ) -School of Medicine, Johns Hopkins University ( JHU ) -Johns Hopkins Bloomberg School of Public Health, University of Pennsylvania [Philadelphia]-Perelman School of Medicine, University of Lausanne-Center for Integrated Genomics, Virginia Polytechnic Institute and State University [Blacksburg]-VA-MD Regional College of Veterinary Medicine, University of Illinois at Chicago ( UIC ), State University of New York at Buffalo ( SUNY Buffalo ) -University of Buffalo School of Medicine and Biomedical Sciences, University of California [Riverside] (UCR), University of California-University of California, Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-CIBER de Enfermedades Raras (CIBERER), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Johns Hopkins University School of Medicine-The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine [Baltimore]-Johns Hopkins University School of Medicine [Baltimore], Utrecht University [Utrecht]-University Medical Center [Utrecht], Universidad Autonoma de Madrid (UAM)-School of Medicine, Cancer Center-Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston], Friedrich-Alexander Universität Erlangen-Nürnberg (FAU)-Emil-Fischer-Zentrum-Institut fuer Biochemie, School of Molecular and Biomedical Science-University of Adelaide, School of Medicine-Department of Radiology-Johns Hopkins University (JHU), University of California-University of California-David Geffen School of Medicine [Los Angeles], Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU)-Johns Hopkins University (JHU), University of Pennsylvania [Philadelphia], Université de Lausanne (UNIL)-Center for Integrated Genomics, AII - Amsterdam institute for Infection and Immunity, and Cell Biology and Histology
Subjects: Encyclopedias as Topic, INFORMATION, WIKI, Transcription, Genetic, 05 Environmental Sciences, Medizin, [SDV.GEN] Life Sciences [q-bio]/Genetics, Automate Content, Web API, ANNOTATION, Mini review, Mice, 0302 clinical medicine, Portable Document Format, GENETICS & HEREDITY, Databases, Protein, Informática, 0303 health sciences, PROTEIN DATA-BANK, Application programming interface, BIOTECHNOLOGY & APPLIED MICROBIOLOGY, MENDELIAN-INHERITANCE, ddc:57, [ SDV.BBM.GTP ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], 030220 oncology & carcinogenesis, Application Programming Interface, Encyclopedia, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], The Internet, Transcription (software), Transcription, Life Sciences & Biomedicine, KNOWLEDGEBASE, Medicina, DATABASE, Bioinformatics, Biology, Medizinische Fakultät » Universitätsklinikum Essen » Institut für Zellbiologie (Tumorforschung), World Wide Web, Access to Information, 03 medical and health sciences, Databases, Genetic, Protein Data Bank, ddc:570, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], ddc:61, Animals, Humans, ddc:610, MeSH Term, Transcription factor, 030304 developmental biology, Internet, 08 Information And Computing Sciences, [SDV.GEN]Life Sciences [q-bio]/Genetics, Science & Technology, GENE-REGULATION, business.industry, Protein, Computational Biology, 06 Biological Sciences, Compendium, EVOLUTION, Rats, Evolutionary biology, UPDATE, business, [ SDV.GEN ] Life Sciences [q-bio]/Genetics, Software, Transcription Factors
Abstract: Here we present the Transcription Factor Encyclopedia (TFe), a new web-based compendium of mini review articles on transcription factors (TFs) that is founded on the principles of open access and collaboration. Our consortium of over 100 researchers has collectively contributed over 130 mini review articles on pertinent human, mouse and rat TFs. Notable features of the TFe website include a high-quality PDF generator and web API for programmatic data retrieval. TFe aims to rapidly educate scientists about the TFs they encounter through the delivery of succinct summaries written and vetted by experts in the field. TFe is available at http://www.cisreg.ca/tfe.
Published: 2012

5. Knockdown of T-cell intracellular antigens triggers cell proliferation, invasion and tumor growth

Author: Raquel Reyes, Isabel Carrascoso, José Alcalde, María Dolores Ludeña, José M. Izquierdo, Genome Dynamics and Function, Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), and Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: Angiogenesis, T cell, Transplantation, Heterologous, Mice, Nude, Biology, Biochemistry, Poly(A)-Binding Proteins, Transcriptome, 03 medical and health sciences, Mice, 0302 clinical medicine, Cell Movement, Neoplasms, medicine, Gene silencing, Animals, Humans, Genes, Tumor Suppressor, Neoplasm Invasiveness, Epigenetics, RNA, Small Interfering, Molecular Biology, 030304 developmental biology, Cell Proliferation, 0303 health sciences, Gene knockdown, Cell growth, Life Sciences, Cell Biology, 3. Good health, Cell biology, T-Cell Intracellular Antigen-1, Tumor Burden, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Gene Knockdown Techniques, Female, Intracellular, HeLa Cells
Abstract: TIA (T-cell intracellular antigen) proteins function as DNA/RNA trans-acting regulators to expand transcriptome and proteome diversity in mammals. In the present paper we report that the stable silencing of TIA1 and/or TIAR/TIAL1 (TIA1-related/like protein 1) expression in HeLa cells enhances cell proliferation, anchorage-dependent and -independent growth and invasion. HeLa cells lacking TIA1 and/or TIAR generate larger and faster-growing epithelial tumours with high rates of proliferation and angiogenesis in nude mice xenografts. Protein array analysis of a collection of human tumours shows that TIA1 and TIAR protein expression is down-regulated in a subset of epithelial tumours relative to normal tissues. Our results suggest a link between the epigenetic control exerted by TIA proteins and the transcriptional and post-transcriptional regulation of a subset of specific genes involved in tumour progression. Taken together, these results are consistent with a role for TIA proteins as growth/tumour-suppressor genes.
Published: 2011

6. Canonical metrics on holomorphic Courant algebroids

Author: Mario Garcia‐Fernandez, Roberto Rubio, Carlos Shahbazi, Carl Tipler, Instituto de Ciencias Matematicas (ICMAT), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut de Physique Théorique - UMR CNRS 3681 (IPHT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Mathématiques de Bretagne Atlantique (LMBA), Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), ANR-11-LABX-0020,LEBESGUE,Centre de Mathématiques Henri Lebesgue : fondements, interactions, applications et Formation(2011), Laboratoire de mathématiques de Brest ( LM ), Université de Brest ( UBO ) -Institut Brestois du Numérique et des Mathématiques ( IBNM ), Université de Brest ( UBO ) -Centre National de la Recherche Scientifique ( CNRS ), HEP, INSPIRE, Laboratoire de mathématiques de Brest (LM), Université de Brest (UBO)-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), and Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: Mathematics - Differential Geometry, High Energy Physics - Theory, geometry, [PHYS.HTHE]Physics [physics]/High Energy Physics - Theory [hep-th], space: Calabi-Yau, General Mathematics, [PHYS.MPHY]Physics [physics]/Mathematical Physics [math-ph], FOS: Physical sciences, [PHYS.MPHY] Physics [physics]/Mathematical Physics [math-ph], holomorphic, [ PHYS.HTHE ] Physics [physics]/High Energy Physics - Theory [hep-th], Mathematics - Algebraic Geometry, Mathematics::Algebraic Geometry, Differential Geometry (math.DG), High Energy Physics - Theory (hep-th), Mathematics - Symplectic Geometry, [MATH.MATH-DG]Mathematics [math]/Differential Geometry [math.DG], FOS: Mathematics, Symplectic Geometry (math.SG), [PHYS.HTHE] Physics [physics]/High Energy Physics - Theory [hep-th], [ PHYS.MPHY ] Physics [physics]/Mathematical Physics [math-ph], holonomy, Mathematics::Differential Geometry, Algebraic Geometry (math.AG), Mathematics::Symplectic Geometry
Abstract: The solution of the Calabi Conjecture by Yau implies that every K\"ahler Calabi-Yau manifold $X$ admits a metric with holonomy contained in $\textrm{SU}(n)$, and that these metrics are parametrized by the positive cone in $H^{1,1}(X,\mathbb{R})$. In this work we give evidence of an extension of Yau's theorem to non-K\"ahler manifolds, where $X$ is replaced by a compact complex manifold with vanishing first Chern class endowed with a holomorphic Courant algebroid $Q$ of Bott-Chern type. The equations that define our notion of best metric correspond to a mild generalization of the Hull-Strominger system, whereas the role of $H^{1,1}(X,\mathbb{R})$ is played by an affine space of 'Aeppli classes' naturally associated to $Q$ via Bott-Chern secondary characteristic classes., Comment: 55 pages, Lemma 2.2 fixed, presentation improved, appendix added, to appear in the Proceedings of the London Mathematical Society
Published: 2022

7. Activity-dependent translocation of neurogranin to neuronal nuclei

Author: F. Javier Díez-Guerra, Lara Duran-Trio, Alberto Garrido-García, Beatriz Andrés-Pans, Depto Biología Molecular, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), and Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: Male, Cytoplasm, Calmodulin, Amino Acid Motifs, Green Fluorescent Proteins, Molecular Sequence Data, Active Transport, Cell Nucleus, Hippocampal formation, Hippocampus, Synaptic Transmission, Biochemistry, Cell Line, Mice, 03 medical and health sciences, Prosencephalon, 0302 clinical medicine, medicine, Animals, Humans, Amino Acid Sequence, Neurogranin, Molecular Biology, Protein kinase C, 030304 developmental biology, Cell Nucleus, Neurons, 0303 health sciences, Microscopy, Confocal, biology, Life Sciences, Cell Biology, Rats, Cell biology, Protein Transport, Cell nucleus, medicine.anatomical_structure, Synaptic plasticity, Forebrain, NIH 3T3 Cells, biology.protein, Calcium, 030217 neurology & neurosurgery, Nuclear localization sequence, HeLa Cells, Protein Binding
Abstract: Long-term changes of synaptic plasticity depend on protein synthesis and transcription. Ng (neurogranin) is a small protein concentrated at dendrites and spines of forebrain neurons, involved in synaptic plasticity through the regulation of CaM (calmodulin)-mediated signalling. Ng presents a central IQ motif that mediates its binding to CaM and PA (phosphatidic acid) and that can be phosphorylated by PKC (protein kinase C). In the present manuscript, we report that Ng displays a strong nuclear localization when expressed in cell lines and hippocampal neurons, either alone or fused to GFP (green fluorescent protein; GFP–Ng). Furthermore, using subcellular fractionation and immunocytochemical techniques, we were able to localize endogenous Ng in the nuclei of rat forebrain neurons. Nuclear localization of Ng depends on its IQ motif and is reduced by binding to cytoplasmic CaM. Also, PKC stimulation induces a transient nuclear translocation of Ng in acute hippocampal slices. A similar translocation is observed in the neurons of the cerebral cortex and hippocampus after the induction of generalized seizures in adult rats. In summary, the results of the present study show that a fraction of rat brain Ng is localized in the neuronal nuclei and that synaptic activity regulates its translocation from the cytoplasm. The possible involvement of Ng in the regulation of intranuclear Ca2+/CaM-dependent signalling and gene expression is discussed.
Published: 2009

8. Neurogranin binds to phosphatidic acid and associates to cellular membranes

Author: Silvia Vázquez-Cuesta, F. Javier Díez-Guerra, Alicia Algaba, Irene Domínguez-González, Ministerio de Ciencia y Tecnología (España), Fundación Ramón Areces, Comunidad de Madrid, Depto Biología Molecular, Centro de Biología Molecular Severo Ochoa, Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), and Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: Dendritic spine, Calmodulin, Phosphatidic Acids, Biology, Phospholipase D (PLD), Protein kinase C (PKC), Biochemistry, Antibodies, 03 medical and health sciences, chemistry.chemical_compound, GAP-43 Protein, 0302 clinical medicine, Phosphatidic acid, Animals, Neurogranin, Phosphatidylinositol, Molecular Biology, Protein kinase C, 030304 developmental biology, 0303 health sciences, Phospholipase D, Cell Membrane, Life Sciences, Dendrites, Cell Biology, Molecular biology, Recombinant Proteins, Rats, 3. Good health, Cell biology, Phosphotransferases (Alcohol Group Acceptor), chemistry, Phosphatidylinositol 4,5-bisphosphate, 13. Climate action, Liposomes, Synapses, Phosphatidylcholines, biology.protein, Rabbits, 030217 neurology & neurosurgery, Signal Transduction, Research Article
Abstract: The final version of record is available at http://dx.doi.org/10.1042/BJ20061483, Neurogranin (Ng) is a 78-amino-acid-long protein concentrated at dendritic spines of forebrain neurons that is involved in synaptic plasticity through the regulation of CaM (calmodulin)-mediated signalling. Ng features a central IQ motif that mediates binding to CaM and is phosphorylated by PKC (protein kinase C). We have analysed the subcellular distribution of Ng and found that it associates to cellular membranes in rat brain. In vitro binding assays revealed that Ng selectively binds to PA (phosphatidic acid) and that this interaction is prevented by CaM and PKC phosphorylation. Using the peptide Ng-(29–47) and a mutant with an internal deletion (Ng-IQless), we have shown that Ng binding to PA and to cellular membranes is mediated by its IQ motif. Ng expressed in NIH-3T3 cells accumulates at peripheral regions of the plasma membrane and localizes at intracellular vesicles that can be clearly visualized following saponin permeabilization. This distribution was affected by PLD (phospholipase D) and PIP5K (phosphatidylinositol 4-phosphate 5-kinase) overexpression. Based on these results, we propose that Ng binding to PA may be involved in Ng accumulation at dendritic spines and that Ng could modulate PA signalling in the postsynaptic environment., This work was supported by a grant from the Spanish Ministry of Science and Technology (BFI2002- 01581). We thank “Fundación Ramón Areces” for institutional support. Irene Domínguez-González was recipient of a fellowship from the Comunidad Autónoma de Madrid (CAM)
Published: 2007

9. Theoretical and numerical perspectives on cosmic distance averages

Author: Pierre Fleury, Michel-Andrès Breton, Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire d'Astrophysique de Marseille (LAM), and Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Length scale, large-scale structure of Universe, distance scale, cosmology: theory, methods: numerical, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Structure formation, media_common.quotation_subject, FOS: Physical sciences, General Relativity and Quantum Cosmology (gr-qc), Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, distance scale, 01 natural sciences, Cosmology, Distance measures, General Relativity and Quantum Cosmology, methods: numerical, symbols.namesake, Friedmann–Lemaître–Robertson–Walker metric, cosmology: theory, 0103 physical sciences, Statistical physics, 010303 astronomy & astrophysics, media_common, Physics, 010308 nuclear & particles physics, Astronomy and Astrophysics, Redshift, Universe, Gravitational lens, Space and Planetary Science, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], symbols, large-scale structure of Universe, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: The interpretation of cosmological observations relies on a notion of an average Universe, which is usually considered as the homogeneous and isotropic Friedmann-Lema\^itre-Robertson-Walker (FLRW) model. However, inhomogeneities may statistically bias the observational averages with respect to FLRW, notably for distance measurements, due to a number of effects such as gravitational lensing and redshift perturbations. In this article, we review the main known theoretical results on average distance measures in cosmology, based on second-order perturbation theory, and we fill in some of their gaps. We then comprehensively test these theoretical predictions against ray tracing in a high-resolution dark-matter $N$-body simulation. This method allows us to describe the effect of small-scale inhomogeneities deep into the non-linear regime of structure formation on light propagation up to $z=10$. We find that numerical results are in remarkably good agreement with theoretical predictions in the limit of super-sample variance. No unexpectedly large bias originates from very small scales, whose effect is fully encoded in the non-linear power spectrum. Specifically, the directional average of the inverse amplification and the source-averaged amplification are compatible with unity; the change in area of surfaces of constant cosmic time is compatible with zero; the biases on other distance measures, which can reach slightly less than $1\%$ at high redshift, are well understood. As a side product, we also confront the predictions of the recent finite-beam formalism with numerical data and find excellent agreement., Comment: 21+8 pages, 23 figures. Accepted version
Published: 2021

10. Thermal transport, geometry, and anomalies

Author: Maxim N. Chernodub, Yago Ferreiros, Adolfo G. Grushin, Karl Landsteiner, María A.H. Vozmediano, Institut Denis Poisson (IDP), Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Université d'Orléans (UO), Instituto Imdea Nanociencia, Théorie de la Matière Condensée (TMC), Institut Néel (NEEL), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), and Centre National de la Recherche Scientifique (CNRS)-Université de Tours (UT)-Université d'Orléans (UO)
Subjects: High Energy Physics - Theory, Condensed Matter - Materials Science, High Energy Physics - Theory (hep-th), Condensed Matter - Mesoscale and Nanoscale Physics, [PHYS.HTHE]Physics [physics]/High Energy Physics - Theory [hep-th], Mesoscale and Nanoscale Physics (cond-mat.mes-hall), Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences, General Physics and Astronomy, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat]
Abstract: The relation between thermal transport and gravity was highlighted in the seminal work by Luttinger in 1964, and has been extensively developed to understand thermal transport, most notably the thermal Hall effect. Here we review the novel concepts that relate thermal transport, the geometry of space-time and quantum field theory anomalies. We give emphasis to the cross-pollination between emergent ideas in condensed matter, notably Weyl and Dirac semimetals, and the understanding of gravitational and scale anomalies stemming from high-energy physics. We finish by relating to recent experimental advances and presenting a perspective of several open problems., 68 pages, 13 figures; comments welcome!
Published: 2021

11. The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo

Author: Jaime de Juan-Sanz, Anjali Amrapali Vishwanath, Andrés de la Rocha-Muñoz, Beatriz López-Corcuera, Carmen Aragón, Dhanasak Dhanasobhon, Nelson Rebola, Enrique Núñez, Sergio Gomez-Lopez, Universidad Autónoma de Madrid (UAM), Hospital Universitario La Paz, Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), HAL-SU, Gestionnaire, UAM. Departamento de Biología Molecular, Universidad Autonoma de Madrid (UAM), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Ministerio de Economía y Competitividad (España), Fundación Ramón Areces, and Banco Santander
Subjects: Embryo, Nonmammalian, Glycine Transporter, [SDV]Life Sciences [q-bio], Wistar, Medicine (miscellaneous), Glycine transporter, 0302 clinical medicine, Glycine Plasma Membrane Transport Proteins, Hyperekplexia, Biology (General), Transporters in the nervous system, Glycine receptor, Zebrafish, 0303 health sciences, Sonic Hedgehog Protein, Nonmammalian, Chemistry, SLC6A5 Protein, Biología y Biomedicina / Biología, Hedgehog signaling pathway, 3. Good health, Cell biology, [SDV] Life Sciences [q-bio], Embryo, embryonic structures, Zebrafish Protein, medicine.symptom, General Agricultural and Biological Sciences, Signal Transduction, animal structures, QH301-705.5, Neurotransmission, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, medicine, Animals, Hedgehog Proteins, Rats, Wistar, Hedgehog, 030304 developmental biology, Zebrafish Proteins, Cellular neuroscience, Rats, Metabolism, Glycine, Rat, Glycinergic synapse, 030217 neurology & neurosurgery
Abstract: The identity of a glycinergic synapse is maintained presynaptically by the activity of a surface glycine transporter, GlyT2, which recaptures glycine back to presynaptic terminals to preserve vesicular glycine content. GlyT2 loss-of-function mutations cause Hyperekplexia, a rare neurological disease in which loss of glycinergic neurotransmission causes generalized stiffness and strong motor alterations. However, the molecular underpinnings controlling GlyT2 activity remain poorly understood. In this work, we identify the Hedgehog pathway as a robust controller of GlyT2 expression and transport activity. Modulating the activation state of the Hedgehog pathway in vitro in rodent primary spinal cord neurons or in vivo in zebrafish embryos induced a selective control in GlyT2 expression, regulating GlyT2 transport activity. Our results indicate that activation of Hedgehog reduces GlyT2 expression by increasing its ubiquitination and degradation. This work describes a new molecular link between the Hedgehog signaling pathway and presynaptic glycine availability., By modulating the activation state of the Hedgehog pathway, de la Rocha-Muñoz et al demonstrate that Hedgehog signaling controls the expression and transport activity of the neuronal glycine transporter GlyT2. This work begins to reveal a potential link between the Hedgehog signaling pathway and presynaptic glycine availability.
Published: 2021

12. New minimal, median, and maximal propagation models for dark matter searches with Galactic cosmic rays

Author: David Maurin, P. Salati, Nathanael Weinrich, Marco Cirelli, Julien Lavalle, Laurent Derome, Yoann Génolini, Mathieu Boudaud, Niels Bohr Institute [Copenhagen] (NBI), Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire de Physique Théorique et Hautes Energies (LPTHE), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy-le-Vieux de Physique Théorique (LAPTH), and Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)
Subjects: electron, HIGH-ENERGY, POWER REQUIREMENTS, halo, Primordial black hole, Astrophysics, Electron, antinucleus, 01 natural sciences, 98.70.Sa, High Energy Physics - Phenomenology (hep-ph), benchmark, Positron, PAMELA, propagation, transport theory, AMS, 12.60.-i, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, REACCELERATION, Annihilation, High Energy Physics - Phenomenology, SAMPLE TRANSPORT, covariance, cosmic radiation: galaxy, PARTICLE PHYSICS, 95.35.+d, Halo, Astrophysics - High Energy Astrophysical Phenomena, black hole: primordial, positron: background, 96.50.S, IN-DIFFUSION MODELS, Astrophysics::High Energy Astrophysical Phenomena, Dark matter, FOS: Physical sciences, SOURCE PARAMETERS, Cosmic ray, Astrophysics::Cosmology and Extragalactic Astrophysics, SPATIAL ORIGIN, 0103 physical sciences, MONTE-CARLO TECHNIQUE, 010306 general physics, 98.35.Gi, anti-p: secondary, dark matter: annihilation, flux, Antiproton, [PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], SOLAR MODULATION, Physics::Accelerator Physics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], statistical
Abstract: Galactic charged cosmic rays (notably electrons, positrons, antiprotons and light antinuclei) are powerful probes of dark matter annihilation or decay, in particular for candidates heavier than a few MeV or tiny evaporating primordial black holes. Recent measurements by PAMELA, AMS-02, or VOYAGER on positrons and antiprotons already translate into constraints on several models over a large mass range. However, these constraints depend on Galactic transport models, in particular the diffusive halo size, subject to theoretical and statistical uncertainties. We update the so-called MIN-MED-MAX benchmark transport parameters that yield generic minimal, median and maximal dark-matter induced fluxes; this reduces the uncertainties on fluxes by a factor of about 2 for positrons and 6 for antiprotons, with respect to their former version. We also provide handy fitting formulae for the associated predicted secondary antiproton and positron background fluxes. Finally, for more refined analyses, we provide the full details of the model parameters and covariance matrices of uncertainties., 20 pages, 9 figures, 6 tables
Published: 2021

13. New cosmic ray MIN-MED-MAX benchmark models for dark matter indirect signatures

Author: Pierre Salati, Laurent Derome, Julien Lavalle, Marco Cirelli, Mathieu Boudaud, Pasquale D. Serpico, David Maurin, Yoann Génolini, Laboratoire d'Annecy-le-Vieux de Physique Théorique (LAPTH), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut de Physique Théorique - UMR CNRS 3681 (IPHT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Niels Bohr Institute [Copenhagen] (NBI), Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Physics, [PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], Dark matter, Benchmark (computing), Cosmic ray, Astrophysics, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2021

14. KIF13A drives AMPA receptor synaptic delivery for long-term potentiation via endosomal remodeling

Author: Cédric Delevoye, Sergio López-García, José A. Esteban, Yolanda Gutiérrez, Silvia Gutiérrez-Eisman, Argentina Lario, Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Biologie Cellulaire et Cancer, Institut Curie [Paris]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Ministerio de Ciencia e Innovación (España), Institut National de la Santé et de la Recherche Médicale (France), Institut Curie, Centre National de la Recherche Scientifique (France), and Ministerio de Educación y Ciencia (España)
Subjects: Male, MESH: Hippocampus, MESH: Rats, Long-Term Potentiation, MESH: Neurons, Kinesins, Endosomes, AMPA receptor, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Hippocampus, Article, MESH: Synapses, Motor protein, 03 medical and health sciences, 0302 clinical medicine, MESH: Long-Term Potentiation, LTP induction, Animals, MESH: Animals, Receptors, AMPA, Rats, Wistar, Cytoskeleton, 030304 developmental biology, Neurons, 0303 health sciences, Trafficking, musculoskeletal, neural, and ocular physiology, Glutamate receptor, Long-term potentiation, Cell Biology, MESH: Rats, Wistar, MESH: Male, Rats, Cell biology, nervous system, MESH: Endosomes, MESH: Receptors, AMPA, Synapses, Endosomal transport, Synaptic plasticity, Kinesin, Female, MESH: Kinesin, MESH: Female, 030217 neurology & neurosurgery, Neuroscience
Abstract: Gutiérrez et al. describe a novel function for the molecular motor KIF13A, in complex with centaurin-α1, for the insertion of AMPA receptors at synapses during long-term potentiation. This process is mediated by the remodeling of intracellular endosomal compartments in the dendritic shaft., The regulated trafficking of AMPA-type glutamate receptors (AMPARs) from dendritic compartments to the synaptic membrane in response to neuronal activity is a core mechanism for long-term potentiation (LTP). However, the contribution of the microtubule cytoskeleton to this synaptic transport is still unknown. In this work, using electrophysiological, biochemical, and imaging techniques, we have found that one member of the kinesin-3 family of motor proteins, KIF13A, is specifically required for the delivery of AMPARs to the spine surface during LTP induction. Accordingly, KIF13A depletion from hippocampal slices abolishes LTP expression. We also identify the vesicular protein centaurin-α1 as part of a motor transport machinery that is engaged with KIF13A and AMPARs upon LTP induction. Finally, we determine that KIF13A is responsible for the remodeling of Rab11-FIP2 endosomal structures in the dendritic shaft during LTP. Overall, these results identify specific kinesin molecular motors and endosomal transport machinery that catalyzes the dendrite-to-synapse translocation of AMPA receptors during synaptic plasticity.
Published: 2021

15. Constructing Turing complete Euler flows in dimension 3

Author: Francisco Presas, Robert Cardona, Eva Miranda, Daniel Peralta-Salas, Universitat Politècnica de Catalunya [Barcelona] (UPC), Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Instituto de Ciencias Matemàticas [Madrid] (ICMAT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM)-Universidad Carlos III de Madrid [Madrid] (UC3M), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Ministerio de Ciencia, Innovación y Universidades (España), Observatoire de Paris, Université Paris sciences et lettres (PSL), Universidad Autónoma de Madrid (UAM), Universitat Politècnica de Catalunya. Departament de Matemàtiques, Universitat Politècnica de Catalunya. GEOMVAP - Geometria de Varietats i Aplicacions, Universidad Autonoma de Madrid (UAM), and Universidad Carlos III de Madrid [Madrid] (UC3M)-Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM)-Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: FOS: Computer and information sciences, Generalized shifts, [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS], MathematicsofComputing_NUMERICALANALYSIS, Mathematics::Analysis of PDEs, Dynamical Systems (math.DS), Computational Complexity (cs.CC), 01 natural sciences, 53 Differential geometry [Classificació AMS], Physics::Fluid Dynamics, contact geometry, Mathematics - Analysis of PDEs, Political science, Incompressible Euler equations, 0103 physical sciences, FOS: Mathematics, Incompressible euler equations, Turing complete, Mathematics - Dynamical Systems, 0101 mathematics, [MATH]Mathematics [math], 010306 general physics, generalized shifts, Multidisciplinary, 010102 general mathematics, Matemàtiques i estadística [Àrees temàtiques de la UPC], language.human_language, incompressible Euler equations, Computer Science - Computational Complexity, TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES, Mathematics - Symplectic Geometry, Contact geometry, Physical Sciences, language, Symplectic Geometry (math.SG), Catalan, Christian ministry, Humanities, Beltrami flow, Analysis of PDEs (math.AP)
Abstract: Can every physical system simulate any Turing machine? This is a classical problem that is intimately connected with the undecidability of certain physical phenomena. Concerning fluid flows, Moore [C. Moore, Nonlinearity 4, 199 (1991)] asked if hydrodynamics is capable of performing computations. More recently, Tao launched a program based on the Turing completeness of the Euler equations to address the blow-up problem in the Navier¿Stokes equations. In this direction, the undecidability of some physical systems has been studied in recent years, from the quantum gap problem to quantum-field theories. To the best of our knowledge, the existence of undecidable particle paths of three-dimensional fluid flows has remained an elusive open problem since Moore¿s works in the early 1990s. In this article, we construct a Turing complete stationary Euler flow on a Riemannian S3 and speculate on its implications concerning Tao¿s approach to the blow-up problem in the Navier¿Stokes equations., Robert Cardona was supported by the Spanish Ministry of Economy and Competitiveness, through the María de Maeztu Program for Units of Excellence in R&D (MDM-2014-0445) via an FPI grant. R.C. and E.M. are partially supported by Grants MTM2015-69135-P/FEDER, the Spanish Ministry of Science and Innovation PID2019-103849GB-I00/AEI/10.13039/501100011033, and Agència de Gestió d’Ajuts Universitaris i de Recerca Grant 2017SGR932. E.M. is supported by the Catalan Institution for Research and Advanced Studies via an ICREA Academia Prize 2016. D.P.-S. is supported by MICINN Grant MTM PID2019-106715GB-C21 and MCIU Grant Europa Excelencia EUR2019-103821. F.P. is supported by MICINN/FEDER Grants MTM2016-79400-P and PID2019-108936GB-C21. This work was partially supported by ICMAT–Severo Ochoa Grant CEX2019-000904-S.
Published: 2021

16. Digestion of in duodenum cannulated pigs. Correlation between in vitro simulated gastric digestion and in vivo data

Author: Miralles, B., Sanchón, J., Sánchez-Rivera, L., Martínez-Maqueda, D., Le Gouar, Y., Dupont, Didier, Amigo, L., Recio, I., Instituto de Investigación en Ciencias de la Alimentación (CIAL), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Science et Technologie du Lait et de l'Oeuf (STLO), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and his work has received financial support from project AGL2015-66886-R from the Spanish Ministry of Economy and Competitiveness(MINECO) and PID2019-107663RB-I00 from the Spanish Ministry ofScience and Innovation. B. Miralles would like to acknowledge CSICproject201870I055.J.S.acknowledgesMINECOforhisFPIfellowshi
Subjects: Pig duodenum, In vitro digestion, Caseins, Amino acids, In vivo digestion, Peptidomics, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: International audience; Correlation and validation of the results of simulated gastrointestinal digestion of food compounds towards in vivo data is essential. The objective of this work was to monitor the digestion of milk micellar casein in the porcine upper intestinal tract and to match the outcome with the gastric in vitro digestion following the Infogest harmonized protocol. In pig duodenum, small amounts of intact caseins were present in all samples, while caseins were observed up to 60 min of gastric in vitro digestion. The peptide profile generated after in vitro and in vivo digestion showed clear similarities with specific overrepresented regions rich in proline and other hydrophobic residues. The statistical comparison of the in vivo and in vitro peptidome resulted in satisfactory correlation coefficients, up to 0.8. Therefore, the in vitro protocol used was a robust and simple model that provides a similar peptide profile than that found in porcine duodenum.
Published: 2021

17. Stability in Gagliardo-Nirenberg-Sobolev inequalities: flows, regularity and the entropy method

Author: Bonforte, Matteo, Dolbeault, Jean, Nazaret, Bruno, Simonov, Nikita, Instituto de Ciencias Matemàticas [Madrid] (ICMAT), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM)-Universidad Carlos III de Madrid [Madrid] (UC3M), CEntre de REcherches en MAthématiques de la DEcision (CEREMADE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), SAMM - Statistique, Analyse et Modélisation Multidisciplinaire (SAmos-Marin Mersenne) (SAMM), Université Paris 1 Panthéon-Sorbonne (UP1), Fédération Parisienne de Modélisation Mathématique (FP2M), Centre National de la Recherche Scientifique (CNRS), Méthodes numériques pour le problème de Monge-Kantorovich et Applications en sciences sociales (MOKAPLAN), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Project MTM2017-85757-P (Ministry of Science and Innovation, Spain) and the Spanish Ministry of Science and Innovation, through the 'Severo Ochoa Programme for Centres of Excellence in R&D' (CEX2019-000904-S)E.U. H2020 MSCA programme, grant agreement 777822Project EFI (ANR-17-CE40-0030) of the French National Research Agency (ANR)Inria Mokaplan teamDIM Math-Innov of the Region Île-de-France, ANR-17-CE40-0030,EFI,Entropie, flots, inégalités(2017), European Project: 777822,GHAIA(2017), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM)-Universidad Carlos III de Madrid [Madrid] (UC3M), Statistique, Analyse et Modélisation Multidisciplinaire (SAmos-Marin Mersenne) (SAMM), Inria de Paris, and Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-CEntre de REcherches en MAthématiques de la DEcision (CEREMADE)
Subjects: intermediate asymptotics, Mathematics::Analysis of PDEs, fast diffusion equation, rates of convergence, stability, Harnack Principle, 26D10, 46E35, 35K55, 49J40, 35B40, 49K20, 49K30, 35J20, Mathematics - Analysis of PDEs, Hardy-Poincaré inequalities, spectral gap, FOS: Mathematics, [MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP], self-similar Barenblatt solutions, asymptotic behavior, 2020 Mathematics Subject Classification.26D10, 46E35, 35K55, 49J40, 35B40, 49K20, 49K30, 35J20, Gagliardo-Nirenberg inequality, Analysis of PDEs (math.AP), entropy methods
Abstract: The purpose of this work is to establish a quantitative and constructive stability result for a class of subcritical Gagliardo-Nirenberg-Sobolev inequalities which interpolates between the logarithmic Sobolev inequality and the standard Sobolev inequality (in dimension larger than three), or Onofri's inequality in dimension two. We develop a new strategy, in which the flow of the fast diffusion equation is used as a tool: a stability result in the inequality is equivalent to an improved rate of convergence to equilibrium for the flow. The regularity properties of the parabolic flow allow us to connect an improved entropy - entropy production inequality during an initial time layer to spectral properties of a suitable linearized problem which is relevant for the asymptotic time layer. Altogether, the stability in the inequalities is measured by a deficit which controls in strong norms (a Fisher information which can be interpreted as a generalized Heisenberg uncertainty principle) the distance to the manifold of optimal functions. The method is constructive and, for the first time, quantitative estimates of the stability constant are obtained, including in the critical case of Sobolev's inequality. To build the estimates, we establish a quantitative global Harnack principle and perform a detailed analysis of large time asymptotics by entropy methods., Comment: This manuscript merges 2007.03674: Stability in Gagliardo-Nirenberg inequalities and 2007.03419: Stability in Gagliardo-Nirenberg inequalities. Supplementary material with several additions including: Chapter 1 (variational methods) and Chapter 6 (Sobolev's inequality)
Published: 2021

18. The completed SDSS-IV extended Baryon Oscillation Spectroscopic Survey: N-body mock challenge for the eBOSS emission line galaxy sample

Author: Santiago Avila, Arnaud de Mattia, Kyle S. Dawson, Salman Habib, Johan Comparat, Jiamin Hou, Shadab Alam, Katrin Heitmann, John A. Peacock, Ashley J. Ross, Alexander R. H. Smith, Hélion du Mas des Bourboux, Romain Paviot, Cheng Zhao, V. Ruhlmann-Kleider, Eva Maria Mueller, Graziano Rossi, Faizan G. Mohammad, Stephanie Escoffier, Amélie Tamone, Anand Raichoor, Richard Neveux, Rita Tojeiro, Héctor Gil-Marín, Violeta Gonzalez-Perez, Julian E. Bautista, Mariana Vargas Magaña, Gong-Bo Zhao, Will J. Percival, Etienne Burtin, European Commission, Comunidad de Madrid, National Research Foundation of Korea, Ministry of Education, Science and Technology (South Korea), Centre National de la Recherche Scientifique (France), Institute for Astronomy [Edinburgh] (IfA), University of Edinburgh, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Ecole Polytechnique Fédérale de Lausanne (EPFL), Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institute of Cosmology and Gravitation [Portsmouth] (ICG), University of Portsmouth, Astrophysical Research Institute [Liverpool], Liverpool John Moore University (ljmu), Center for Cosmology & AstroParticle Physics, Ohio State University [Columbus] (OSU), Max Planck Institute for Extraterrestrial Physics (MPE), Max-Planck-Gesellschaft, University of Utah, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Ciencies del Cosmos (ICCUB), Universitat de Barcelona (UB), Institut d'Estudis Espacials de Catalunya (IEEC-CSIC), Argonne National Laboratory [Lemont] (ANL), Department of Physics and Astronomy [Waterloo], University of Waterloo [Waterloo], Department of Physics [Oxford], University of Oxford, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Perimeter Institute for Theoretical Physics [Waterloo], Sejong University, University of St Andrews [Scotland], Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), Institute for Computer Graphics and Vision [Graz] (ICG), Graz University of Technology [Graz] (TU Graz), National Astronomical Observatories [Beijing] (NAOC), Chinese Academy of Sciences [Beijing] (CAS), ANR-16-CE31-0021,eBOSS,Sondes cosmologiques de la gravitation et de l'énergie noire(2016), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), University of Oxford [Oxford], Universidad Nacional Autónoma de México (UNAM), and University of St Andrews. School of Physics and Astronomy
Subjects: analytic model, haloes [Galaxies], Large-scale structure of Universe, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], baryonic effect on galaxies, Astrophysics, power spectrum, 7. Clean energy, 01 natural sciences, Redshift-space distortions, relativistic distortions, Satellite galaxy, QB Astronomy, 010303 astronomy & astrophysics, QC, QB, Physics, robustness of cosmology, 3rd-DAS, Redshift survey, halo occupation distribution, emission line galaxies, astro-ph.CO, Astrophysics - Cosmology and Nongalactic Astrophysics, redshift survey, Cosmology and Nongalactic Astrophysics (astro-ph.CO), astro-ph.GA, Dark matter, Cosmological parameters, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Halo occupation distribution, large-scale structure, 0103 physical sciences, lambda-cdm, evolution, Galaxies: haloes, Astrophysics::Galaxy Astrophysics, Redshift space distortions, 010308 nuclear & particles physics, Spectral density, Astronomy and Astrophysics, space, Astrophysics - Astrophysics of Galaxies, Galaxy, Redshift, QC Physics, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), growth-rate
Abstract: Alam, S., et al., Cosmological growth can be measured in the redshift space clustering of galaxies targeted by spectroscopic surveys. Accurate prediction of clustering of galaxies will require understanding galaxy physics, which is a very hard and highly non-linear problem. Approximate models of redshift space distortion (RSD) take a perturbative approach to solve the evolution of dark matter and galaxies in the universe. In this paper, we focus on extended Baryon Oscillation Spectroscopic (eBOSS) emission line galaxies (ELGs) that live in intermediate mass haloes. We create a series of mock catalogues using haloes from the Multidark and outer rim dark matter only N-body simulations. Our mock catalogues include various effects inspired by baryonic physics such as assembly bias and the characteristics of satellite galaxies kinematics, dynamics, and statistics deviating from dark matter particles. We analyse these mocks using the TNS RSD model in Fourier space and the convolution Lagrangian perturbation theory (CLPT) in configuration space. We conclude that these two RSD models provide an unbiased measurement of RSD within the statistical error of our mocks. We obtain the conservative theoretical systematic uncertainty of $3.3{{\ \rm per\ cent}}$, $1.8{{\ \rm per\ cent}}$, and $1.5{{\ \rm per\ cent}}$ in fσ8, α∥, and α⊥, respectively, for the TNS and CLPT models. We note that the estimated theoretical systematic error is an order of magnitude smaller than the statistical error of the eBOSS ELG sample and hence are negligible for the purpose of the current eBOSS ELG analysis., SA and JAP are supported by the European Research Council through the COSFORM Research Grant (#670193). VGP acknowledges support from the European Union’s Horizon 2020 research and innovation programme (ERC grant #769130) and by the Atracción de Talento Project no. 2019-T1/TIC-12702 granted by the Comunidad de Madrid in Spain. SH and KH acknowledge support under the U.S. Department of Energy contract W-7405-ENG-36 at Argonne National Laboratory. GR acknowledges support from the National Research Foundation of Korea (NRF) through grant 2017R1E1A1A01077508 and No. 2020R1A2C1005655 funded by the Korean Ministry of Education, Science and Technology (MoEST). RP and SE acknowledge support from the French National Research Agency under grants ANR-16-CE31-0021 (ANR eBOSS), ANR-11-LABX-0060 (OCEVU LABEX), and ANR-11-IDEX-0001-02 (A*MIDEX project).
Published: 2021

19. Sur la conjecture de Weinstein singulière et l'existence d'orbites d'échappées pour des champs b-Beltrami

Author: Eva Miranda, Cédric Oms, Daniel Peralta-Salas, Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), Universitat Politècnica de Catalunya [Barcelona] (UPC), Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre de Recerca Matemàtica (CRM), Universitat Autònoma de Barcelona (UAB), Instituto de Ciencias Matemàticas [Madrid] (ICMAT), Universidad Carlos III de Madrid [Madrid] (UC3M)-Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM)-Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM)-Universidad Carlos III de Madrid [Madrid] (UC3M), Universitat Politècnica de Catalunya. Departament de Matemàtiques, and Universitat Politècnica de Catalunya. GEOMVAP - Geometria de Varietats i Aplicacions
Subjects: Reeb dynamics, Applied Mathematics, General Mathematics, FOS: Physical sciences, Geometry, Geometria, Matemàtiques i estadística [Àrees temàtiques de la UPC], Mathematical Physics (math-ph), Dynamical Systems (math.DS), Algebraic geometry, Mathematics - Analysis of PDEs, Geometria algebraica, Mathematics - Symplectic Geometry, FOS: Mathematics, Camps vectorials, Symplectic Geometry (math.SG), Àlgebra, [MATH]Mathematics [math], Mathematics - Dynamical Systems, Poincaré, Conjectura de, Mathematical Physics, Analysis of PDEs (math.AP)
Abstract: Motivated by Poincaré's orbits going to infinity in the (restricted) three-body problem [see H. Poincaré, Les Méthodes Nouvelles de la Mécanique Céleste, Vol. 3 (Gauthier-Villars, 1899) and A. Chenciner, Poincaré and the three-body problem, in Henri Poincaré, 1912-2012 (Birkhäuser, Basel, 2015), pp. 51-149], we investigate the generic existence of heteroclinic-like orbits in a neighborhood of the critical set of a b-contact form. This is done by using a singular counterpart [R. Cardona, E. Miranda and D. Peralta-Salas, Euler flows and singular geometric structures, Philos. Trans. R. Soc. A 377(2158) (2019) 20190034] of Etnyre-Ghrist's contact/Beltrami correspondence [J. Etnyre and R. Ghrist, Contact topology and hydrodynamics: I. Beltrami fields and the Seifert conjecture, Nonlinearity 13(2) (2000) 441-458], and genericity results concerning eigenfunctions of the Laplacian established by Uhlenbeck [Generic properties of eigenfunctions, Amer. J. Math. 98(4) (1976) 1059-1078]. Specifically, we analyze the b-Beltrami vector fields on b-manifolds of dimension 3 and prove that for a generic asymptotically exact b-metric they exhibit escape orbits. We also show that a generic asymptotically symmetric b-Beltrami vector field on an asymptotically flat b-manifold has a generalized singular periodic orbit and at least four escape orbits. Generalized singular periodic orbits are trajectories of the vector field whose ¿-and ¿-limit sets intersect the critical surface. These results are a first step towards proving the singular Weinstein conjecture., E. M. is supported by the Catalan Institution for Research and Advanced Studies via an ICREA Academia Prize 2016. Eva Miranda and Cedric Oms are supported by the grants reference number MTM2015-69135-P (MINECO/FEDER) ´ and reference number 2017SGR932 (AGAUR) and the project PID2019-103849GB-I00 / AEI / 10.13039/501100011033. C. O. has been supported by an FNR-AFR PhD predoctoral grant (project GLADYSS) until October 2nd, 2020 and by a SECTI-Postdoctoral grant financed by Eva Miranda’s ICREA Academia immediately after. D. P.-S. is supported by the grants MTM PID2019-106715GB-C21 (MICINN) and Europa Excelencia EUR2019- 103821 (MCIU). This work is supported in part by the ICMAT–Severo Ochoa grant SEV-2015-0554 and the CSIC grant 20205CEX001.
Published: 2021

20. Parabolic subgroups acting on the additional length graph

Author: Yago Antolín, María Cumplido, Instituto de Ciencias Matemàticas [Madrid] (ICMAT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM)-Universidad Carlos III de Madrid [Madrid] (UC3M), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Institut de Mathématiques de Bourgogne [Dijon] (IMB), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Bourgogne (UB), University of Sevilla, Spanish GovernmentEuropean CommissionMTM2014-53810-C2-01MTM2017-82690-PMTM2016-76453-C2-1-PSpanish Government through the 'Severo Ochoa Programme for Centres of Excellence in RD'SEV-2015-0554European CommissionMTM2016-76453-C2-1-P, Universidad de Sevilla. Departamento de Álgebra, and Universidad de Sevilla. FQM218: Singularidades, Geometría Algebraica Aritmética, Grupos y Homotopía
Subjects: Pure mathematics, media_common.quotation_subject, Braid group, Garside groups, artin-tits groups, Group Theory (math.GR), acylindrically hyperbolic groups, parabolic subgroups, 01 natural sciences, Mathematics::Group Theory, Álgebra, 0103 physical sciences, relative growth, FOS: Mathematics, Uniform boundedness, braid groups, 0101 mathematics, [MATH]Mathematics [math], Mathematics, media_common, growth of groups, Grupos (Matemáticas), Sequence, Group (mathematics), 010102 general mathematics, Infinity, 20F36, 20F65, Artin groups, Generating set of a group, Graph (abstract data type), 010307 mathematical physics, Geometry and Topology, Element (category theory), Mathematics - Group Theory
Abstract: Let $A\neq A_1, A_2, I_{2m}$ be an irreducible Artin--Tits group of spherical type. We show that periodic elements of $A$ and the elements preserving some parabolic subgroup of $A$ act elliptically on the additional length graph $\mathcal{C}_{AL}(A)$, an hyperbolic, infinite diameter graph associated to $A$ constructed by Calvez and Wiest to show that $A/Z(A)$ is acylindrically hyperbolic. We use these results to find an element $g\in A$ such that $\langle P,g \rangle\cong P* \langle g \rangle$ for every proper standard parabolic subgroup $P$ of $A$. The length of $g$ is uniformly bounded with respect to the Garside generators, independently of $A$. This allows us to show that, in contrast with the Artin generators case, the sequence $\{\omega(A_n,\mathcal{S})\}_{n\in \mathbb{N}}$ of exponential growth rates of braid groups with respect to the Garside generating set, goes to infinity., Comment: 19 pages, 2 figures
Published: 2021

21. Oral enzymatic detoxification system: Insights obtained from proteome analysis to understand its potential impact on aroma metabolization

Author: Carolina Muñoz-González, Francis Canon, Jean-Marie Heydel, Fabrice Neiers, Jean-Philippe Charles, Gilles Feron, Mathieu Schwartz, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Instituto de Investigación en Ciencias de la Alimentación (CIAL), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Agence Nationale de la Recherche (Grant Numbers: ANR-14-CE20-0001, ANR-16-CE21-0004, ANR-20-CE21-0002) + INRAE TRANSFORM department (Grant Number: ANS CrysFlavor)., ANR-14-CE20-0001,MUFFIN,Film salivaire muqueux et interactions avec la flaveur(2014), ANR-16-CE21-0004,OLFZYME,Olfaction et enzymes olfactives(2016), ANR-20-CE21-0002,MACARON,Pellicule mucosal, flaveur, interaction & perception(2020), Agence Nationale de la Recherche (France), and Comunidad de Madrid
Subjects: Proteomics, Saliva, Proteome, Context (language use), 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Detoxification, detoxification enzymes, Aroma, 030304 developmental biology, chemistry.chemical_classification, Mouth, 0303 health sciences, saliva, biology, Chemistry, food and beverages, Metabolism, biology.organism_classification, 3. Good health, stomatognathic diseases, Enzyme, Biochemistry, aroma, 030220 oncology & carcinogenesis, Odorants, oral cavity, Xenobiotic, metabolism, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Food Science
Abstract: The oral cavity is an entry path into the body, enabling the intake of nutrients but also leading to the ingestion of harmful substances. Thus, saliva and oral tissues contain enzyme systems that enable the early neutralization of xenobiotics as soon as they enter the body. Based on recently published oral proteomic data from several research groups, this review identifies and compiles the primary detoxification enzymes (also known as xenobiotic-metabolizing enzymes) present in saliva and the oral epithelium. The functions and the metabolic activity of these enzymes are presented. Then, the activity of these enzymes in saliva, which is an extracellular fluid, is discussed with regard to the salivary parameters. The next part of the review presents research evidencing oral metabolization of aroma compounds and the putative involved enzymes. The last part discusses the potential role of these enzymatic reactions on the perception of aroma compounds in light of recent pieces of evidence of in vivo oral metabolization of aroma compounds affecting their release in mouth and their perception. Thus, this review highlights different enzymes appearing as relevant to explain aroma metabolism in the oral cavity. It also points out that further works are needed to unravel the effect of the oral enzymatic detoxification system on the perception of food flavor in the context of the consumption of complex food matrices, while considering the impact of food oral processing. Thus, it constitutes a basis to explore these biochemical mechanisms and their impact on flavor perception., This work was supported by the “Agence Nationale de la Recherche” (ANR), Grant Numbers: ANR-16-CE21-0004, ANR-14-CE20-0001, and ANR-20-CE21-0002. Mathieu Schwartz was supported by the INRAE TRANSFORM department (ANS CrysFlavor). Carolina Muñoz-González thanks the Atracción de Talento programme (2019T1/BIO13748).
Published: 2021

22. On the modified logarithmic Sobolev inequality for the heat-bath dynamics for 1D systems

Author: Ivan Bardet, Cambyse Rouzé, David Pérez-García, Angelo Lucia, Angela Capel, Cryptologie symétrique, cryptologie fondée sur les codes et information quantique (COSMIQ), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Instituto de Ciencias Matemàticas [Madrid] (ICMAT), Universidad Carlos III de Madrid [Madrid] (UC3M)-Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM)-Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), California Institute of Technology (CALTECH), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Ivan Bardet is supported by French A.N.R. grant: ANR-14-CE25-0003 'StoQ'. Angela Capel is partially supported by a La Caixa-Severo Ochoa grant (ICMAT Severo Ochoa project SEV-2011-0087, MINECO) and Angela Capel and David Perez Garcia acknowledge support from MINECO (grant MTM2017-88385-P) and from Comunidad de Madrid (grantQUITEMAD-CM, ref. P2018/TCS-4342). Angelo Lucia acknowledges support from the Walter Burke Institute for Theoretical Physics in the form of the Sherman Fairchild Fellowship as well as support from the Institute for Quantum Information and Matter (IQIM), an NSF Physics Frontiers Center (NFS Grant PHY-1733907), and from the BBVA Fundation.This project has received funding from the European Research Council (ERC) under theEuropean Union’s Horizon 2020 research and innovation programme (grant agreementNo 648913). Cambyse Rouzé acknowledges financial support from the TUM university Foundation Fellowship and by the DFG cluster of excellence 2111 (Munich Center for Quantum Science and Technology)., Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM)-Universidad Carlos III de Madrid [Madrid] (UC3M), Security, Cryptology and Transmissions (SECRET), Instituto de Ciencias Matemàticas [Madrid], Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Universidad Complutense de Madrid [Madrid] (UCM), and Technische Universität München [München] (TUM)
Subjects: [PHYS.MPHY]Physics [physics]/Mathematical Physics [math-ph], FOS: Physical sciences, Gibbs state, [MATH.MATH-FA]Mathematics [math]/Functional Analysis [math.FA], 01 natural sciences, Entropy (classical thermodynamics), symbols.namesake, [PHYS.QPHY]Physics [physics]/Quantum Physics [quant-ph], 0103 physical sciences, 0101 mathematics, Gibbs measure, Mixing (physics), Condensed Matter - Statistical Mechanics, Mathematical Physics, Mathematical physics, Mathematics, Quantum Physics, Statistical Mechanics (cond-mat.stat-mech), 010102 general mathematics, Statistical and Nonlinear Physics, Mathematical Physics (math-ph), Sobolev space, symbols, Dissipative system, 010307 mathematical physics, Constant (mathematics), Quantum Physics (quant-ph), Hamiltonian (control theory)
Abstract: The mixing time of Markovian dissipative evolutions of open quantum many-body systems can be bounded using optimal constants of certain quantum functional inequalities, such as the modified logarithmic Sobolev constant. For classical spin systems, the positivity of such constants follows from a mixing condition for the Gibbs measure, via quasi-factorization results for the entropy. Inspired by the classical case, we present a strategy to derive the positivity of the modified logarithmic Sobolev constant associated to the dynamics of certain quantum systems from some clustering conditions on the Gibbs state of a local, commuting Hamiltonian. In particular we show that for the heat-bath dynamics for 1D systems, the modified logarithmic Sobolev constant is positive under the assumptions of a mixing condition on the Gibbs state and a strong quasi-factorization of the relative entropy., 28 pages, 4 figures. Included some additional comments and updated results in light of recent advances in the literature
Published: 2021
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23. The Completed SDSS-IV Extended Baryon Oscillation Spectroscopic Survey: N-body mock challenge for galaxy clustering measurements

Author: Kyle S. Dawson, Jeongin Moon, Etienne Burtin, Katrin Heitmann, Gong-Bo Zhao, Héctor Gil-Marín, Will J. Percival, Stephanie Escoffier, Peter Doohyun Choi, Jiamin Hou, Sylvain de la Torre, Salman Habib, Alexander R. H. Smith, Ashley J. Ross, Santiago Avila, Julian E. Bautista, S. Fromenteau, Eva-Maria Mueller, Cheng Zhao, Mariana Vargas-Magaña, Graziano Rossi, Romain Paviot, Sejong University, Institute of Cosmology and Gravitation [Portsmouth] (ICG), University of Portsmouth, Institut de Ciencies del Cosmos (ICCUB), Universitat de Barcelona (UB), Institute for Space Studies of Catalonia [Barcelona] (IEEC-CSIC), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), Instituto de Ciencias Físicas, Center for Cosmology & AstroParticle Physics, Ohio State University [Columbus] (OSU), Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, University of Utah, Argonne National Laboratory [Lemont] (ANL), Max Planck Institute for Extraterrestrial Physics (MPE), Max-Planck-Gesellschaft, Department of Physics [Oxford], University of Oxford, Department of Physics and Astronomy [Waterloo], University of Waterloo [Waterloo], Perimeter Institute for Theoretical Physics [Waterloo], Ecole Polytechnique Fédérale de Lausanne (EPFL), National Astronomical Observatories [Beijing] (NAOC), Chinese Academy of Sciences [Beijing] (CAS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ANR-16-CE31-0021,eBOSS,Sondes cosmologiques de la gravitation et de l'énergie noire(2016), ANR-11-LABX-0060,OCEVU,Origines, Constituants et EVolution de l'Univers(2011), National Research Foundation of Korea, Ministry of Education, Science and Technology (South Korea), Korea Institute of Science and Technology, La Caixa, Universidad Nacional Autónoma de México (UNAM), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), and University of Oxford [Oxford]
Subjects: assembly bias, statistical [Methods], Large-scale structure of Universe, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astrophysics, Galaxies: formation, 01 natural sciences, Redshift-space distortions, analytical [Methods], Galaxy clustering, Methods analytical, Methods: analytical, 010303 astronomy & astrophysics, Methods: statistical, satellite kinematics, Physics, Galaxy formation, Methods: numerical, Methods numerical, acoustic-oscillations, halo occupation distribution, Halo, Baryon acoustic oscillations, Astrophysics - Cosmology and Nongalactic Astrophysics, Cosmology and Nongalactic Astrophysics (astro-ph.CO), FOS: Physical sciences, Large scale structure of Universe, Astrophysics::Cosmology and Extragalactic Astrophysics, Halo occupation distribution, large-scale structure, redshift-space distortions, theory [Cosmology], Cosmology theory, 0103 physical sciences, Galaxy formation and evolution, Astrophysics::Galaxy Astrophysics, numerical [Methods], 010308 nuclear & particles physics, Astronomy and Astrophysics, formation [Galaxies], Redshift, Galaxy, Baryon, Space and Planetary Science, structure growth, digital sky survey, power-spectrum, Cosmology: theory, dr14 quasar sample, Methods statistical
Abstract: We develop a series of N-body data challenges, functional to the final analysis of the extended Baryon Oscillation Spectroscopic Survey (eBOSS) Data Release 16 (DR16) galaxy sample. The challenges are primarily based on high-fidelity catalogues constructed from the Outer Rim simulation - a large box size realization (3h-1Gpc) characterized by an unprecedented combination of volume and mass resolution, down to 1.85 × 109h-1M. We generate synthetic galaxy mocks by populating Outer Rim haloes with a variety of halo occupation distribution (HOD) schemes of increasing complexity, spanning different redshift intervals. We then assess the performance of three complementary redshift space distortion (RSD) models in configuration and Fourier space, adopted for the analysis of the complete DR16 eBOSS sample of Luminous Red Galaxies (LRGs). We find all the methods mutually consistent, with comparable systematic errors on the Alcock-Paczynski parameters and the growth of structure, and robust to different HOD prescriptions - thus validating the robustness of the models and the pipelines used for the baryon acoustic oscillation (BAO) and full shape clustering analysis. In particular, all the techniques are able to recover α and α to within $0.9{{\ \rm per\ cent}}$, and fσ8 to within $1.5{{\ \rm per\ cent}}$. As a by-product of our work, we are also able to gain interesting insights on the galaxy-halo connection. Our study is relevant for the final eBOSS DR16 'consensus cosmology', as the systematic error budget is informed by testing the results of analyses against these high-resolution mocks. In addition, it is also useful for future large-volume surveys, since similar mock-making techniques and systematic corrections can be readily extended to model for instance the Dark Energy Spectroscopic Instrument (DESI) galaxy sample., GR, PDC, and JM acknowledge support from the National Research Foundation of Korea (NRF) through Grants No. 2017R1E1A1A01077508 and No. 2020R1A2C1005655 funded by the Korean Ministry of Education, Science and Technology (MoEST), and from the faculty research fund of Sejong University. GR was on sabbatical leave in 2020, when this research was completed. Some numerical work performed in this paper was carried out using the Korea Institute of Science and Technology Information (KISTI) supercomputing infrastructure under allocations KSC-2018-G3-0008 and KSC-2018-T1-0061, and with computing resources at Sejong University (Xeon Silver 4114 master node and Xeon Gold 6126 computing node architecture). HGM acknowledges support from la Caixa Foundation (ID 100010434) which code LCF/BQ/PI18/11630024. RP, SdlT, and SE acknowledge support from the eBOSS ANR grant (under contract ANR-16-CE31-0021) and the OCEVU LABEX (Grant No. ANR-11-LABX-0060) of the French National Research Agency.
Published: 2021

24. Kirszbraun's theorem via an explicit formula

Author: Erwan Le Gruyer, Carlos Mudarra, Daniel Azagra, Departamento de Analisis Matemàtico, Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Institut de Recherche Mathématique de Rennes (IRMAR), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Instituto de Ciencias Matematicas (ICMAT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École normale supérieure - Rennes (ENS Rennes)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-INSTITUT AGRO Agrocampus Ouest, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), and Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: General Mathematics, 010102 general mathematics, Hilbert space, Extension (predicate logic), Function (mathematics), Lipschitz continuity, [MATH.MATH-FA]Mathematics [math]/Functional Analysis [math.FA], 01 natural sciences, Functional Analysis (math.FA), 010101 applied mathematics, Combinatorics, Mathematics - Functional Analysis, symbols.namesake, symbols, FOS: Mathematics, Nabla symbol, 0101 mathematics, Convex function, Mathematics
Abstract: Let $X,Y$ be two Hilbert spaces, $E$ a subset of $X$ and $G: E \to Y$ a Lipschitz mapping. A famous theorem of Kirszbraun's states that there exists $\widetilde{G} : X \to Y$ with $\widetilde{G}=G$ on $E$ and $\textrm{Lip}(\widetilde{G})=\textrm{Lip}(G).$ In this note we show that in fact the function $$\widetilde{G}:=\nabla_Y(\textrm{conv}(g))( \cdot , 0), \qquad \text{where} $$ $$ g(x,y) = \inf_{z \in E} \lbrace \langle G(z), y \rangle + \tfrac{M}{2} \|(x-z,y)\|^2 \rbrace + \tfrac{M}{2}\|(x,y)\|^2, $$ defines such an extension. We apply this formula to get an extension result for {\em strongly biLipschitz homeomorphisms.} Related to the latter, we also consider extensions of $C^{1,1}$ strongly convex functions., Comment: 9 pages. We have added some comments and explanations
Published: 2021

25. Operads of (noncrossing) partitions, interacting bialgebras, and moment-cumulant relations

Author: Joachim Kock, Frédéric Patras, Loïc Foissy, Kurusch Ebrahimi-Fard, Instituto de Ciencias Matematicas (ICMAT), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire de Mathématiques Pures et Appliquées Joseph Liouville (LMPA), Université du Littoral Côte d'Opale (ULCO), Laboratoire Jean Alexandre Dieudonné (LJAD), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), European Project: 670624,H2020,ERC-2014-ADG,DuaLL(2015), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire Jean Alexandre Dieudonné (JAD), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Pure mathematics, General Mathematics, Noncrossing partitions, 01 natural sciences, Bialgebra, 16T05, 16T10, 16T30, 18M60, 46L53, 46L54, Comodule, Mathematics::Category Theory, Mathematics::Quantum Algebra, Lattice (order), 0103 physical sciences, Mathematics - Combinatorics, Operads, 0101 mathematics, Cumulant, MSC: 16T05, 16T10, 16T30, 18M60, 46L53, 46L54, Mathematics, Noncrossing partition, 010102 general mathematics, [MATH.MATH-RA]Mathematics [math]/Rings and Algebras [math.RA], Mathematics - Rings and Algebras, 16. Peace & justice, Free probability, Interacting bialgebras, 010307 mathematical physics, Mobius inversion, Mathematics - Probability, Moment-cumulant relations
Abstract: We establish and explore a relationship between two approaches to moment-cumulant relations in free probability theory: on one side the main approach, due to Speicher, given in terms of M\"obius inversion on the lattice of noncrossing partitions, and on the other side the more recent non-commutative shuffle-algebra approach, where the moment-cumulant relations take the form of certain exponential-logarithm relations. We achieve this by exhibiting two operad structures on (noncrossing) partitions, different in nature: one is an ordinary, non-symmetric operad whose composition law is given by insertion into gaps between elements, the other is a coloured, symmetric operad with composition law expressing refinement of blocks. We show that these operad structures interact so as to make the corresponding incidence bialgebra of the former a comodule bialgebra for the latter. Furthermore, this interaction is compatible with the shuffle structure and thus unveils how the two approaches are intertwined. Moreover, the constructions and results are general enough to extend to ordinary set partitions., Comment: 41 pages. v4: Fixed a small mistake on p.23; it does not affect the rest of the paper. Final version, to appear in Adv. Math
Published: 2020

26. Reg-1α Promotes Differentiation of Cortical Progenitors via Its N-Terminal Active Domain

Author: Françoise Trousse, Francisco Nieto-Lopez, Marjorie Varilh, Mireille Rossel, Jean-Michel Verdier, Michelle Silhol, Marie-Christine Lebart, Anne Marcilhac, Paola Bovolenta, Mireille Moussaed, Isabelle Acquatella-Tran Van Ba, Institut National de la Santé et de la Recherche Médicale (France), TROUSSE, Francoise, Mécanismes moléculaires dans les démences neurodégénératives (MMDN), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université Paris sciences et lettres (PSL), Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), and Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: 0301 basic medicine, Nervous system, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, neural progenitors, 0302 clinical medicine, immune system diseases, 10. No inequality, Receptor, [SDV.BDD]Life Sciences [q-bio]/Development Biology, lcsh:QH301-705.5, Original Research, biology, medicine.diagnostic_test, Chemistry, Electroporation, hemic and immune systems, differentiation, Cell biology, medicine.anatomical_structure, Differentiation, GSK-3b, 030220 oncology & carcinogenesis, Proteolysis, chemical and pharmacologic phenomena, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Cell and Developmental Biology, Reg-1a, 03 medical and health sciences, [SDV.BDD] Life Sciences [q-bio]/Development Biology, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, medicine, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Progenitor cell, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Reg-1α, Axon elongation, GSK-3β, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Lectin, axon elongation, Cell Biology, Neural progenitors, Embryonic stem cell, Extl3, 030104 developmental biology, Secretory protein, lcsh:Biology (General), biology.protein, Developmental Biology
Abstract: Reg-1α belongs to the Reg family of small, secreted proteins expressed in both pancreas and nervous system. Reg-1α is composed of two domains, an insoluble C-type lectin domain and a short soluble N-terminal peptide, which is released from the molecule upon proteolytic N-terminal processing, although the biological significance of this proteolysis remains unclear. We have previously shown that binding of Reg-1α to its receptor Extl3 stimulates axonal outgrowth. Reg-1α and Extl3 genes are expressed in the developing cortex but their expression decreases in adulthood, pointing to a possible function of this signaling system at the early developmental stages. Here, we demonstrate that recombinant Reg-1α increases migration and differentiation of cultured embryonic rat telencephalic progenitors via the activation of GSK-3β activity. In vivo overexpression of Reg-1α by in utero electroporation, has a similar effect, favoring premature differentiation of cortical progenitors. Notably, the N-terminal soluble domain, but not the C-type lectin domain, is largely responsible for Reg-1α effects on cortical neuronal differentiation. We thus conclude that Reg-1α via its proteolytically generated N-terminal domain is required for basic development processes., Institut national de la santé et de la recherche de Médicale
Published: 2020

27. Possible Formation and Destruction of the OD+ Ions in the Interstellar Medium

Author: Octavio Roncero, François Lique, Niyazi Bulut, European Commission, Institut Universitaire de France, Centre National de la Recherche Scientifique (France), Ministerio de Ciencia, Innovación y Universidades (España), Centro de Supercomputación de Galicia, Department of Physics, Firat, Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire Ondes et Milieux Complexes (LOMC), Centre National de la Recherche Scientifique (CNRS)-Université Le Havre Normandie (ULH), and Normandie Université (NU)-Normandie Université (NU)
Subjects: [PHYS]Physics [physics], 010304 chemical physics, Chemistry, Astrophysics::High Energy Astrophysical Phenomena, Molecular cloud, chemistry.chemical_element, Cosmic ray, Astrophysics::Cosmology and Extragalactic Astrophysics, 010402 general chemistry, 01 natural sciences, 7. Clean energy, Oxygen, 0104 chemical sciences, Ion, Interstellar medium, 13. Climate action, Chemical physics, Ionization, TRACER, 0103 physical sciences, Physical and Theoretical Chemistry, ComputingMilieux_MISCELLANEOUS, Astrophysics::Galaxy Astrophysics
Abstract: 10 pags., 13 figs., The OH+ ion is an important constituent of the interstellar medium (ISM). It can be used as a probe of cosmic ray and X-ray ionization rates in molecular clouds as well as a tracer of oxygen chemistry. The deuterated variant of OH+, the OD+ ion, may also be present in the ISM despite the fact that it has not been detected yet. In this paper, we aim at providing quantitative insight into the OD+ chemistry and at accurately studying the possible formation and destruction processes of OD+ in the ISM. We study the formation and destruction of OD+ through the O+ + HD → OD+ + H and OH+ + D ↔ OD+ + H reactions that can occur in diffuse ISM. Reactive rate constants have been obtained from exact state-to-state quantum wave packet calculations for temperatures ranging from 10 to 1000 K. The new theoretical data are validated through a detailed comparison with available experimental data. The formation of OD+ is found to be less efficient than that of OH+. As a first application, the OD+/OH+ abundance ratio in ISM has been evaluated from a simple astrochemical model, and we found that this ratio can be larger than D/H abundance ratio only at low temperatures. These calculations may help in an astrochemical search of OD+ in cold ISM., We acknowledge the French−Spanish collaborative project PICS (ref. PIC2017FR7). F.L. acknowledges financial support from the European Research Council (Consolidator Grant COLLEXISM, Grant Agreement 811363), the Institut Universitaire de France, and the Programme National ”Physique et Chimie du Milieu Interstellaire” (PCMI) of CNRS/INSU with INC/INP cofunded by CEA and CNES. O.R. acknowledges the support from MICIU under Grant No. FIS2017-83473-C2 and for computing time at Finisterrae (CESGA) and Marenostrum (BSC) under RES Computational Grants ACCT-2019-3-0004 and AECT-2020-1-0003 N.B. acknowledges the computing facilities of TUBITAKTRUBA. This work was performed using HPC resources from GENCI-CINES (Grant A0070411036)
Published: 2020

28. Euclid preparation: VI. Verifying the Performance of Cosmic Shear Experiments (Corrigendum)

Author: Paykari, P., Kitching, T., Hoekstra, H., Azzollini, R., Cardone, V. F., Cropper, M., Duncan, C. A. J., Kannawadi, A., Miller, L., Aussel, H., Conti, I. F., Auricchio, N., Baldi, M., Bardelli, S., Biviano, A., Bonino, D., Borsato, E., Bozzo, E., Branchini, E., Brau-Nogue, S., Brescia, M., Brinchmann, J., Burigana, C., Camera, S., Capobianco, V., Carbone, C., Carretero, J., Casas, S., Castander, F. J., Castellano, M., Cavuoti, S., Charles, Y., Cledassou, R., Colodro-Conde, C., Congedo, G., Conselice, C., Conversi, L., Copin, Y., Coupon, J., Courtois, H. M., da Silva, A., Dupac, X., Fabbian, G., Farrens, S., Ferreira, P. G., Fosalba, P., Fourmanoit, N., Frailis, M., Fumana, M., Galeotta, S., Garilli, B., Gillard, W., Gillis, B. R., Giocoli, C., Graciá-Carpio, J., Grupp, F., Hormuth, F., Ilić, S., Israel, H., Jahnke, K., Keihanen, E., Kermiche, S., Kilbinger, M., Kirkpatrick, C. C., Kubik, B., Kunz, M., Kurki-Suonio, H., Lacasa, F., Laureijs, R., Le Mignant, D., Ligori, S., Lilje, P. B., Lloro, I., Maciaszek, T., Maiorano, E., Marggraf, O., Markovic, K., Martinelli, M., Martinet, N., Marulli, F., Massey, R., Mauri, N., Medinaceli, E., Mei, S., Mellier, Y., Meneghetti, M., Metcalf, R. B., Moresco, M., Moscardini, L., Munari, E., Neissner, C., Nichol, R. C., Niemi, S., Nutma, T., Padilla, C., Paltani, S., Pasian, F., Pettorino, V., Pires, S., Polenta, G., Pourtsidou, A., Raison, F., Renzi, A., Rhodes, J., Romelli, E., Roncarelli, M., Rossetti, E., Saglia, R., Sakr, Z., Sánchez, A. G., Sapone, D., Scaramella, R., Schneider, P., Schrabback, T., Scottez, V., Secroun, A., Serrano, S., Sirignano, C., Sirri, G., Stanco, L., Starck, J.-L., Sureau, F., Tallada-Crespí, P., Taylor, A., Tenti, M., Tereno, I., Toledo-Moreo, R., Torradeflot, F., Tutusaus, I., Valenziano, L., Vannier, M., Vassallo, T., Zoubian, J., Zucca, E., Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique (LERMA (UMR_8112)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Queen Mary University of London (QMUL), Institut d'Estudis Espacials de Catalunya (IEEC-CSIC), Euclid Collaboration, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique et Atmosphères = Laboratory for Studies of Radiation and Matter in Astrophysics and Atmospheres (LERMA), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, and Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY)
Subjects: [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], addenda, errata
Abstract: International audience; Authors Lacasa, Martinelli, Pourtsidou, Tutusaus, were inadvertently missed from the original authorship list. This is now corrected.
Published: 2020

29. Dark photon dark matter in the presence of inhomogeneous structure

Author: S. Rosauro-Alcaraz, Samuel J. Witte, Vivian Poulin, Samuel D. McDermott, European Commission, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Generalitat Valenciana, Instituto de Fisica Corpuscular (IFIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universitat de València (UV), Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Fermilab Center for Particle Astrophysics, Fermi National Accelerator Laboratory (Fermilab), Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), IFAC, Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), UAM. Departamento de Física Teórica, and GRAPPA (ITFA, IoP, FNWI)
Subjects: Nuclear and High Energy Physics, Photon, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Dark matter, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Plasma oscillation, 01 natural sciences, Dark photon, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], High Energy Physics - Phenomenology (hep-ph), 0103 physical sciences, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, Thermal Field Theory, 010306 general physics, Reionization, Physics, Range (particle radiation), 010308 nuclear & particles physics, Star formation, Física, Cosmology of Theories beyond the SM, High Energy Physics - Phenomenology, Orders of magnitude (time), [PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], lcsh:QC770-798, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Dark photon dark matter will resonantly convert into visible photons when the dark photon mass is equal to the plasma frequency of the ambient medium. In cosmological contexts, this transition leads to an extremely efficient, albeit short-lived, heating of the surrounding gas. Existing work in this field has been predominantly focused on understanding the implications of these resonant transitions in the limit that the plasma frequency of the Universe can be treated as being perfectly homogeneous, i.e. neglecting inhomogeneities in the electron number density. In this work we focus on the implications of heating from dark photon dark matter in the presence of inhomogeneous structure (which is particularly relevant for dark photons with masses in the range 10−15 eV ≤ mA’≤ 10−12 eV), emphasizing both the importance of inhomogeneous energy injection, as well as the sensitivity of cosmological observations to the inhomogeneities themselves. More specifically, we derive modified constraints on dark photon dark matter from the Ly-α forest, and show that the presence of inhomogeneities allows one to extend constraints to masses outside of the range that would be obtainable in the homogeneous limit, while only slightly relaxing their strength. We then project sensitivity for near-future cosmological surveys that are hoping to measure the 21cm transition in neutral hydrogen prior to reionization, and demonstrate that these experiments will be extremely useful in improving sensitivity to masses near ∼ 10−14 eV, potentially by several orders of magnitude. Finally, we discuss implications for reionization, early star formation, and late-time y-type spectral distortions, and show that probes which are inherently sensitive to the inhomogeneous state of the Universe could resolve signatures unique to the light dark photon dark matter scenario, and thus offer a fantastic potential for a positive detection, SJW and SR acknowledge support from the European Union's Horizon 2020 research and innovation program under the Marie Sk lodowska-Curie grant agreements No. 690575 and 674896. SJW acknowledges support under Spanish grants FPA2014-57816-P and FPA2017-85985-P of the MINECO and PROMETEO II/2014/050 of the Generalitat Valenciana. SR also acknowledges support from the “Spanish Agencia Estatal de Investigación" (AEI) and the EU “Fondo Europeo de Desarrollo Regional" (FEDER) through the project FPA2016-78645-P; and through the Centro de Excelencia Severo Ochoa Program under grant SEV-2016-0597. Fermilab is operated by Fermi Research Alliance, LLC under Contract No. DEAC02-07CH11359 with the United States Department of Energy
Published: 2020

30. Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

Author: Kos, Z., Roblin, E., Kim, R. S., Michiels, S., Gallas, B. D., Chen, W., van de Vijver, K. K., Goel, S., Adams, S., Demaria, S., Viale, G., Nielsen, T. O., Badve, S. S., Symmans, W. F., Sotiriou, C., Rimm, D. L., Hewitt, S., Denkert, C., Loibl, S., Luen, S. J., Bartlett, J. M. S., Savas, P., Pruneri, G., Dillon, D. A., Cheang, M. C. U., Tutt, A., Hall, J. A., Kok, M., Horlings, H. M., Madabhushi, A., van der Laak, J., Ciompi, F., Laenkholm, A. -V., Bellolio, E., Gruosso, T., Fox, S. B., Araya, J. C., Floris, G., Hudecek, J., Voorwerk, L., Beck, A. H., Kerner, J., Larsimont, D., Declercq, S., Van den Eynden, G., Pusztai, L., Ehinger, A., Yang, W., Abduljabbar, K., Yuan, Y., Singh, R., Hiley, C., Bakir, M., Lazar, A. J., Naber, S., Wienert, S., Castillo, M., Curigliano, G., Dieci, M. -V., Andre, F., Swanton, C., Reis-Filho, J., Sparano, J., Balslev, E., Chen, I. -C., Stovgaard, E. I. S., Pogue-Geile, K., Blenman, K. R. M., Penault-Llorca, F., Schnitt, S., Lakhani, S. R., Vincent-Salomon, A., Rojo, F., Braybrooke, J. P., Hanna, M. G., Soler-Monso, M. T., Bethmann, D., Castaneda, C. A., Willard-Gallo, K., Sharma, A., Lien, H. -C., Fineberg, S., Thagaard, J., Comerma, L., Gonzalez-Ericsson, P., Brogi, E., Loi, S., Saltz, J., Klaushen, F., Cooper, L., Amgad, M., Moore, D. A., Salgado, R., Hyytiainen, A., Hida, A. I., Thompson, A., Lefevre, A., Gown, A., Lo, A., Sapino, A., Moreira, A. M., Richardson, A., Vingiani, A., Bellizzi, A. M., Guerrero, A., Grigoriadis, A., Garrido-Castro, A. C., Cimino-Mathews, A., Srinivasan, A., Acs, B., Singh, B., Calhoun, B., Haibe-Kans, B., Solomon, B., Thapa, B., Nelson, B. H., Ballesteroes-Merino, C., Criscitiello, C., Boeckx, C., Colpaert, C., Quinn, C., Chennubhotla, C. S., Solinas, C., Drubay, D., Sabanathan, D., Peeters, D., Zardavas, D., Hoflmayer, D., Johnson, D. B., Thompson, E. A., Perez, E., Elgabry, E. A., Blackley, E. F., Reisenbichler, E., Chmielik, E., Gaire, F., F. -I., Lu, Azmoudeh-Ardalan, F., Peale, F., Hirsch, F. R., Acosta-Haab, G., Farshid, G., Broeckx, G., Koeppen, H., Haynes, H. R., Mcarthur, H., Joensuu, H., Olofsson, H., Cree, I., Nederlof, I., Frahm, I., Brcic, I., Chan, J., Ziai, J., Brock, J., Weseling, J., Giltnane, J., Lemonnier, J., Zha, J., Ribeiro, J., Lennerz, J. K., Carter, J. M., Hartman, J., Hainfellner, J., Le Quesne, J., Juco, J. W., van den Berg, J., Sanchez, J., Cucherousset, J., Adam, J., Balko, J. M., Saeger, K., Siziopikou, K., Sikorska, K., Weber, K., Steele, K. E., Emancipator, K., El Bairi, K., Allison, K. H., Korski, K., Buisseret, L., Shi, L., Kooreman, L. F. S., Molinero, L., Estrada, M. V., Van Seijen, M., Lacroix-Triki, M., Sebastian, M. M., Balancin, M. L., Mathieu, M. -C., van de Vijver, M., Rebelatto, M. C., Piccart, M., Goetz, M. P., Preusser, M., Khojasteh, M., Sanders, M. E., Regan, M. M., Barnes, M., Christie, M., Misialek, M., Ignatiadis, M., de Maaker, M., Van Bockstal, M., Harbeck, N., Tung, N., Laudus, N., Sirtaine, N., Burchardi, N., Ternes, N., Radosevic-Robin, N., Gluz, O., Grimm, O., Nuciforo, P., Jank, P., Kirtani, P., Watson, P. H., Jelinic, P., Francis, P. A., Russell, P. A., Pierce, R. H., Hills, R., Leon-Ferre, R., de Wind, R., Shui, R., Leung, S., Tabbarah, S., Souza, S. C., O'Toole, S., Swain, S., Dudgeon, S., Willis, S., Ely, S., Bedri, S., Irshad, S., Liu, S., Hendry, S., Bianchi, S., Braganca, S., Paik, S., Luz, S., Gevaert, T., D'Alfons, T., John, T., Sugie, T., Kurkure, U., Bossuyt, V., Manem, V., Camaea, V. P., Tong, W., Tran, W. T., Wang, Y., Allory, Y., Husain, Z., Bago-Horvath, Z., Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Institut Gustave Roussy (IGR), Division of Pathology and Laboratory Medicine, Università degli Studi di Milano [Milano] (UNIMI)-European Institute of Oncology [Milan] (ESMO), Institut Jules Bordet [Bruxelles], Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Charité, Institute of Pathology, Translational Tumorpathology Unit, German Breast Group, University of the Sunshine Coast (USC), European Institute of Oncology [Milan] (ESMO), Breakthrough Breast Cancer Centre, London Institute of Cancer, Department of Pathology, The Netherlands Cancer Institute, Division of Experimental Therapy, The Netherlands Cancer Institute NKI/AvL, Odense University Hospital, Unité de génétique et biologie des cancers (U830), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Breast Medical Oncology [Houston], The University of Texas M.D. Anderson Cancer Center [Houston], Helsingborg Hospital, Division of Experimental Therapeutics [Milan, Italy], Département de médecine oncologique [Gustave Roussy], Cancer Research UK Lung Cancer Centre of Excellence [Londres, Royaume-Uni], University College of London [London] (UCL), Memorial Sloane Kettering Cancer Center [New York], Herlev and Gentofte Hospital, Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Southern Queensland (USQ), Pharmacogenomics Unit [Paris], Department of Genetics [Paris], Institut Curie [Paris]-Institut Curie [Paris], Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Ctr Biomol Struct & Org, University of Maryland [College Park], University of Maryland System-University of Maryland System, The University of Sydney, Breast Cancer Translational Research Laboratory, Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB)-Faculté de Médecine [Bruxelles] (ULB), Innovation North - Faculty of Information and Technology, Leeds Metropolitan University, Int Immuno-Oncology Biomarker, Graduate School, CCA - Cancer biology and immunology, Pathology, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Oncostat (U1018 (Équipe 2)), Institut Gustave Roussy (IGR)-Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Università degli Studi di Milano = University of Milan (UNIMI)-European Institute of Oncology [Milan] (ESMO), German Breast Group (GBG), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Gallas, Brandon D [0000-0001-7332-1620], van de Vijver, Koen K [0000-0002-2026-9790], Demaria, Sandra [0000-0003-4426-0499], Badve, Sunil S [0000-0001-8861-9980], Symmans, W Fraser [0000-0002-1526-184X], Rimm, David L [0000-0001-5820-4397], Savas, Peter [0000-0001-5999-428X], Hall, Jacqueline A [0000-0003-0708-1360], Horlings, Hugo M [0000-0003-4782-8828], van der Laak, Jeroen [0000-0001-7982-0754], Bellolio, Enrique [0000-0003-0079-5264], Araya, Juan Carlos [0000-0003-3501-8203], Floris, Giuseppe [0000-0003-2391-5425], Hudeček, Jan [0000-0003-1071-5686], Ehinger, Anna [0000-0001-9225-7396], Lazar, Alexander J [0000-0002-6395-4499], Castillo, Miluska [0000-0002-0111-3176], Curigliano, Giuseppe [0000-0003-1781-2518], Sparano, Joseph [0000-0002-9031-2010], Braybrooke, Jeremy P [0000-0003-1943-7360], Hanna, Matthew G [0000-0002-7536-1746], Willard-Gallo, Karen [0000-0002-1150-1295], Sharma, Ashish [0000-0002-1011-6504], Comerma, Laura [0000-0002-0249-4636], Gonzalez-Ericsson, Paula [0000-0002-6292-6963], Loi, Sherene [0000-0001-6137-9171], Cooper, Lee [0000-0002-3504-4965], Apollo - University of Cambridge Repository, Research Programs Unit, Heikki Joensuu / Principal Investigator, HUS Comprehensive Cancer Center, Department of Oncology, Medicum, Gallas, Brandon D. [0000-0001-7332-1620], van de Vijver, Koen K. [0000-0002-2026-9790], Badve, Sunil S. [0000-0001-8861-9980], Symmans, W. Fraser [0000-0002-1526-184X], Rimm, David L. [0000-0001-5820-4397], Hall, Jacqueline A. [0000-0003-0708-1360], Horlings, Hugo M. [0000-0003-4782-8828], Lazar, Alexander J. [0000-0002-6395-4499], Braybrooke, Jeremy P. [0000-0003-1943-7360], and Hanna, Matthew G. [0000-0002-7536-1746]
Subjects: Oncology, [SDV]Life Sciences [q-bio], THERAPY, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Prognostic markers, 0302 clinical medicine, Breast cancer, Medicine and Health Sciences, Pharmacology (medical), Lymphocytes, Stromal tumor, health care economics and organizations, 0303 health sciences, CHEMOTHERAPY, Sciences bio-médicales et agricoles, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], PROGNOSTIC VALUE, Clinical Practice, 030220 oncology & carcinogenesis, Educational resources, Immunosurveillance, medicine.medical_specialty, 3122 Cancers, [SDV.CAN]Life Sciences [q-bio]/Cancer, IMMUNITY, lcsh:RC254-282, Article, Limfòcits, Càncer de mama, 03 medical and health sciences, Gastrointestinal cancer, SDG 3 - Good Health and Well-being, Internal medicine, 692/53/2422, medicine, Radiology, Nuclear Medicine and imaging, Càncer gastrointestinal, 030304 developmental biology, Predictive biomarker, Tumor-infiltrating lymphocytes, business.industry, Médecine pathologie humaine, medicine.disease, Cancérologie, Human medicine, business, SYSTEM, 631/67/580/1884
Abstract: Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been widely embraced by the clinical and research communities. We evaluated sources of variability in sTIL assessment by pathologists in three previous sTIL ring studies. We identify common challenges and evaluate impact of discrepancies on outcome estimates in early TNBC using a newly-developed prognostic tool. Discordant sTIL assessment is driven by heterogeneity in lymphocyte distribution. Additional factors include: technical slide-related issues; scoring outside the tumor boundary; tumors with minimal assessable stroma; including lymphocytes associated with other structures; and including other inflammatory cells. Small variations in sTIL assessment modestly alter risk estimation in early TNBC but have the potential to affect treatment selection if cutpoints are employed. Scoring and averaging multiple areas, as well as use of reference images, improve consistency of sTIL evaluation. Moreover, to assist in avoiding the pitfalls identified in this analysis, we developed an educational resource available at www.tilsinbreastcancer.org/pitfalls., info:eu-repo/semantics/published
Published: 2020

31. Théorie de Jauge pour les algébroides des cordes

Author: Garcia-Fernandez, Mario, Rubio, Roberto, Tipler, Carl, Instituto de Ciencias Matematicas (ICMAT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universitat Autònoma de Barcelona (UAB), Laboratoire de Mathématiques de Bretagne Atlantique (LMBA), and Université de Brest (UBO)-Université de Bretagne Sud (UBS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: High Energy Physics::Theory, Mathematics::Algebraic Geometry, [MATH.MATH-DG]Mathematics [math]/Differential Geometry [math.DG], Mathematics::Symplectic Geometry
Abstract: We introduce a moment map picture for holomorphic string algebroids where the Hamiltonian gauge action is described by means of Morita equivalences, as suggested by higher gauge theory. The zero locus of our moment map is given by the solutions of the Calabi system, a coupled system of equations which provides a unifying framework for the classical Calabi problem and the Hull-Strominger system. Our main results are concerned with the geometry of the moduli space of solutions, and assume a technical condition which is fulfilled in examples. We prove that the moduli space carries a pseudo-Kähler metric with Kähler potential given by the dilaton functional, a topological formula for the metric, and an infinitesimal Donaldson-Uhlenbeck-Yau type theorem. Finally, we relate our topological formula to a physical prediction for the gravitino mass in order to obtain a new conjectural obstruction for the Hull-Strominger system.
Published: 2020

32. Diacylglycerol kinase ¿ promotes actin cytoskeleton remodeling and mechanical forces at the B cell immune synapse

Author: Sara V. Merino-Cortes, Paolo Pierobon, Ana-Maria Lennon Dumenil, Yolanda R. Carrasco, Ana Martínez-Riaño, Sara Roman-Garcia, Rosa Liébana, Julien Husson, Sofia R. Gardeta, Balbino Alarcón, Judith Pineau, Isabel Mérida, Ministerio de Economía y Competitividad (España), Worldwide Cancer Research, LabexMER, Agence Nationale de la Recherche (France), Centre National de la Recherche Scientifique (France), Centro Nacional de Biotecnología [Madrid] (CNB-CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Immunité et cancer (U932), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'hydrodynamique (LadHyX), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), and Pierobon, Paolo
Subjects: Diacylglycerol Kinase, Immunological Synapses, T cell, Lymphocyte, [SDV.BBM.BP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biochemistry, Immunological synapse, Mice, 03 medical and health sciences, 0302 clinical medicine, Antigen, medicine, Animals, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Molecular Biology, Cytoskeleton, B cell, 030304 developmental biology, Diacylglycerol kinase, Mice, Knockout, B-Lymphocytes, 0303 health sciences, Chemistry, Germinal center, Actin remodeling, Cell Biology, 3. Good health, Cell biology, [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, medicine.anatomical_structure, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, [SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology, 030217 neurology & neurosurgery
Abstract: Diacylglycerol kinases (DGKs) limit antigen receptor signaling in immune cells by consuming the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA). Here, we showed that DGKζ promotes lymphocyte function–associated antigen 1 (LFA-1)–mediated adhesion and F-actin generation at the immune synapse of B cells with antigen-presenting cells (APCs), mostly in a PA-dependent manner. Measurement of single-cell mechanical force generation indicated that DGKζ-deficient B cells exerted lower forces at the immune synapse than did wild-type B cells. Nonmuscle myosin activation and translocation of the microtubule-organizing center (MTOC) to the immune synapse were also impaired in DGKζ-deficient B cells. These functional defects correlated with the decreased ability of B cells to present antigen and activate T cells in vitro. The in vivo germinal center response of DGKζ-deficient B cells was also reduced compared with that of wild-type B cells, indicating that loss of DGKζ in B cells impaired T cell help. Together, our data suggest that DGKζ shapes B cell responses by regulating actin remodeling, force generation, and antigen uptake–related events at the immune synapse. Hence, an appropriate balance in the amounts of DAG and PA is required for optimal B cell function., SVMC is supported by an FPI contract from the Spanish Ministry of Economy (MINECO; BES-2014-068006). This work was supported by grants from the MINECO (BFU2013-48828-P) and from the Worldwide Cancer Research (WCR; grant reference number 15-1322). JH has benefited from the financial support of the LabeX LaSIPS (ANR-10-LABX-0040-LaSIPS) managed by the French National Research Agency under the “Investissements d’avenir” program (nº ANR-11-IDEX-0003-02), and from a PEPS CNRS funding.
Published: 2020

33. A group-theoretical approach to conditionally free cumulants

Author: Kurusch Ebrahimi-Fard, Frédéric Patras, Instituto de Ciencias Matematicas (ICMAT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire Jean Alexandre Dieudonné (JAD), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), F. Chapoton et al. eds, and ANR-12-BS01-0017,CARMA,Combinatoire Algébrique, Résurgence, Moules et Applications(2012)
Subjects: Pure mathematics, Group (mathematics), Infinitesimal, Probability (math.PR), [MATH.MATH-RA]Mathematics [math]/Rings and Algebras [math.RA], 010102 general mathematics, Structure (category theory), 16. Peace & justice, Hopf algebra, 01 natural sciences, Shuffle algebra, Probability theory, 0103 physical sciences, Lie algebra, FOS: Mathematics, 0101 mathematics, Algebraic number, 010306 general physics, Mathematics - Probability, Mathematics
Abstract: In this work we extend the recently introduced group-theoretical approach to moment-cumulant relations in non-commutative probability theory to the notion of conditionally free cumulants. This approach is based on a particular combinatorial Hopf algebra which may be characterised as a non-cocommutative generalisation of the classical unshuffle Hopf algebra. Central to our work is the resulting non-commutative shuffle algebra structure on the graded dual. It implies an extension of the classical relation between the group of Hopf algebra characters and its Lie algebra of infinitesimal characters and, among others, the appearance of new forms of adjoint actions of the group on its Lie algebra which happens to play a key role in the new algebraic understanding of conditionally free cumulants., Comment: 24 pages
Published: 2020

34. Conserved quantities on multisymplectic manifolds

Author: Leonid Ryvkin, Marco Zambon, Tilmann Wurzbacher, Fakultät für Mathematik [Bochum], Ruhr-Universität Bochum [Bochum], Institut Élie Cartan de Lorraine (IECL), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Instituto de Ciencias Matematicas (ICMAT), and Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: Mathematics - Differential Geometry, Pure mathematics, Differential form, General Mathematics, FOS: Physical sciences, homotopy co-momentum map, Dynamical Systems (math.DS), 01 natural sciences, FOS: Mathematics, Mathematics - Dynamical Systems, 0101 mathematics, Mathematics::Symplectic Geometry, Mathematical Physics, Mathematics, Science & Technology, GEOMETRY, 010102 general mathematics, L-INFINITY-ALGEBRAS, Lie group, Mathematical Physics (math-ph), Conserved quantity, Manifold, multisymplectic manifolds, 010101 applied mathematics, Differential Geometry (math.DG), Mathematics - Symplectic Geometry, [MATH.MATH-DG]Mathematics [math]/Differential Geometry [math.DG], Physical Sciences, Homogeneous space, Symplectic Geometry (math.SG), Vector field, Lie derivative, conservation laws, Symplectic geometry
Abstract: Given a vector field on a manifold M, we define a globally conserved quantity to be a differential form whose Lie derivative is exact. Integrals of conserved quantities over suitable submanifolds are constant under time evolution, the Kelvin circulation theorem being a well-known special case. More generally, conserved quantities are well-behaved under transgression to spaces of maps into M. We focus on the case of multisymplectic manifolds and Hamiltonian vector fields. We show that in the presence of a Lie group of symmetries admitting a homotopy co-momentum map, one obtains a whole family of globally conserved quantities. This extends a classical result in symplectic geometry. We carry this out in a general setting, considering several variants of the notion of globally conserved quantity., Comment: 24 pages
Published: 2020

35. Holomorphic string algebroids

Author: Carl Tipler, Mario Garcia-Fernandez, Roberto Rubio, Instituto de Ciencias Matematicas (ICMAT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire de Mathématiques de Bretagne Atlantique (LMBA), Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de mathématiques de Brest (LM), Université de Brest (UBO)-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), and HEP, INSPIRE
Subjects: High Energy Physics - Theory, Mathematics - Differential Geometry, Pure mathematics, family, General Mathematics, [PHYS.MPHY]Physics [physics]/Mathematical Physics [math-ph], String group, Holomorphic function, FOS: Physical sciences, algebra: Lie, 01 natural sciences, Mathematics - Algebraic Geometry, Morphism, Mathematics::K-Theory and Homology, Mathematics::Quantum Algebra, Mathematics::Category Theory, C++ string handling, FOS: Mathematics, 0101 mathematics, Differential graded Lie algebra, Algebraic Geometry (math.AG), Mathematics::Symplectic Geometry, Čech cohomology, Mathematics, category: holomorphic, Mathematics::Complex Variables, Applied Mathematics, 010102 general mathematics, deformation, [PHYS.MPHY] Physics [physics]/Mathematical Physics [math-ph], 16. Peace & justice, High Energy Physics - Theory (hep-th), Differential Geometry (math.DG), [MATH.MATH-DG]Mathematics [math]/Differential Geometry [math.DG], string, graded, cohomology
Abstract: We introduce the category of holomorphic string algebroids, whose objects are Courant extensions of Atiyah Lie algebroids of holomorphic principal bundles, as considered by Bressler, and whose morphisms correspond to inner morphisms of the underlying holomorphic Courant algebroids in the sense of Severa. This category provides natural candidates for Atiyah Lie algebroids of holomorphic principal bundles for the (complexified) string group and their morphisms. Our main results are a classification of string algebroids in terms of Cech cohomology, and the construction of a locally complete family of deformations of string algebroids via a differential graded Lie algebra., Comment: 41 pages, Sections 2 and 3 improved, to appear in Transactions of the American Mathematical Society
Published: 2020

36. Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group

Author: Laura Comerma, Marie-Christine Mathieu, Joel H. Saltz, Giancarlo Pruneri, Peter Savas, Shom Goel, Stephan Wienert, Paula I. Gonzalez-Ericsson, Lee Cooper, Sunil R. Lakhani, Stefan Michiels, Pawan Kirtani, Sarah N Dudgeon, Francesco Ciompi, Uday Kurkure, Manu M. Sebastian, Giuseppe Viale, Brandon D. Gallas, Mohamed Amgad, John M. S. Bartlett, Jan Hudecek, Torsten O. Nielsen, Elisabeth Specht Stovgaard, Huang-Chun Lien, Alexander J. Lazar, Johan Hartman, Yinyin Yuan, Rim S. Kim, Jeppe Thagaard, Ashish Sharma, Sylvia Adams, Matthew G. Hanna, Stephen M. Hewitt, Weijie Chen, David L. Rimm, Khalid AbdulJabbar, Sibylle Loibl, Jochen K. Lennerz, I-Chun Chen, Zsuzsanna Bago-Horvath, Mehrnoush Khojasteh, Frédérique Penault-Llorca, Katherine L. Pogue-Geile, Federico Rojo, Marcelo Luiz Balancin, David Moore, Stuart J. Schnitt, Roberto Salgado, Loes F. S. Kooreman, Sherene Loi, Jeremy P Braybrooke, Eva Balslev, Leonie Voorwerk, Sunil S. Badve, Elvire Roblin, Jennifer K. Kerner, Marleen Kok, Andrew H. Beck, Michael Barnes, Jeroen van der Laak, Carsten Denkert, W. Fraser Symmans, Zuzana Kos, Rajendra Singh, Anant Madabhushi, Christos Sotiriou, Sandra Demaria, Hugo M. Horlings, Department of Pathology, Herlev and Gentofte Hospital, The University of Sydney, Charité, Institute of Pathology, Translational Tumorpathology Unit, Division of Experimental Therapy, The Netherlands Cancer Institute NKI/AvL, Innovation North - Faculty of Information and Technology, Leeds Metropolitan University, Pathologie morphologique, Département de biologie et pathologie médicales [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), European Institute of Oncology [Milan] (ESMO), University of Southern Queensland (USQ), Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut Jules Bordet [Bruxelles], Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Division of Pathology and Laboratory Medicine, Università degli Studi di Milano = University of Milan (UNIMI)-European Institute of Oncology [Milan] (ESMO), University of the Sunshine Coast (USC), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), German Breast Group (GBG), Breast Cancer Translational Research Laboratory, Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB)-Faculté de Médecine [Bruxelles] (ULB), Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR), Oncostat (U1018 (Équipe 2)), Institut Gustave Roussy (IGR)-Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, The Netherlands Cancer Institute, The University of Texas M.D. Anderson Cancer Center [Houston], Medizinische Universität Wien = Medical University of Vienna, Computational Biomedicine Lab (CBL), University of Houston, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'anatomie pathologique, Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Università degli Studi di Milano [Milano] (UNIMI)-European Institute of Oncology [Milan] (ESMO), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), German Breast Group, Medical University of Vienna, Department of Pathology, Amgad, Mohamed [0000-0001-7599-6162], Sharma, Ashish [0000-0002-1011-6504], Savas, Peter [0000-0001-5999-428X], Hudeček, Jan [0000-0003-1071-5686], Braybrooke, Jeremy P [0000-0003-1943-7360], Demaria, Sandra [0000-0003-4426-0499], Comerma, Laura [0000-0002-0249-4636], Badve, Sunil S [0000-0001-8861-9980], Symmans, W Fraser [0000-0002-1526-184X], Gonzalez-Ericsson, Paula [0000-0002-6292-6963], Rimm, David L [0000-0001-5820-4397], Loi, Sherene [0000-0001-6137-9171], Hanna, Matthew G [0000-0002-7536-1746], Lazar, Alexander J [0000-0002-6395-4499], Bago-Horvath, Zsuzsanna [0000-0002-8555-7806], van der Laak, Jeroen AWM [0000-0001-7982-0754], Gallas, Brandon D [0000-0001-7332-1620], Kurkure, Uday [0000-0002-8273-7334], Cooper, Lee AD [0000-0002-3504-4965], and Apollo - University of Cambridge Repository
Subjects: 0301 basic medicine, Computer science, [SDV]Life Sciences [q-bio], Review Article, DIGITAL PATHOLOGY, Tumour biomarkers, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Prognostic markers, 0302 clinical medicine, Breast cancer, Ecology,Evolution & Ethology, Visual scoring, Medicine and Health Sciences, Pharmacology (medical), Chemical Biology & High Throughput, Human Biology & Physiology, IN-SITU, Medicinsk bildbehandling, Genome Integrity & Repair, Sciences bio-médicales et agricoles, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, SOLID TUMORS, 3. Good health, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], Oncology, 030220 oncology & carcinogenesis, Tumour immunology, TILS, Tumor immunology, Genetics & Genomics, [SDV.CAN]Life Sciences [q-bio]/Cancer, Cancer imaging, lcsh:RC254-282, CLASSIFICATION, 03 medical and health sciences, Signalling & Oncogenes, STANDARDIZED METHOD, QUALITY-CONTROL, SDG 3 - Good Health and Well-being, BREAST-CANCER, Radiology, Nuclear Medicine and imaging, IMAGE-ANALYSIS, Computational & Systems Biology, Tumor-infiltrating lymphocytes, Digital pathology, Médecine pathologie humaine, Tumour Biology, Data science, Biomarker (cell), Cancérologie, Medical Image Processing, 030104 developmental biology, Workflow, T-CELLS
Abstract: Assessment of tumor-infiltrating lymphocytes (TILs) is increasingly recognized as an integral part of the prognostic workflow in triple-negative (TNBC) and HER2-positive breast cancer, as well as many other solid tumors. This recognition has come about thanks to standardized visual reporting guidelines, which helped to reduce inter-reader variability. Now, there are ripe opportunities to employ computational methods that extract spatio-morphologic predictive features, enabling computer-aided diagnostics. We detail the benefits of computational TILs assessment, the readiness of TILs scoring for computational assessment, and outline considerations for overcoming key barriers to clinical translation in this arena. Specifically, we discuss: 1. ensuring computational workflows closely capture visual guidelines and standards; 2. challenges and thoughts standards for assessment of algorithms including training, preanalytical, analytical, and clinical validation; 3. perspectives on how to realize the potential of machine learning models and to overcome the perceptual and practical limits of visual scoring., info:eu-repo/semantics/published
Published: 2020

37. Euclid preparation

Author: Euclid Collaboration, Paykari, P., Kitching, T., Hoekstra, H., Azzollini, R., CARDONE, Vincenzo Fabrizio, Cropper, M., Duncan, C. A. J., Kannawadi, A., Miller, L., Aussel, H., Polenta, G., Pourtsidou, A., Raison, F., Renzi, A., Rhodes, J., Romelli, Erik, Roncarelli, M., Rossetti, E., Saglia, R., Sakr, Z., Conti, I. F., Sánchez, A. G., Sapone, D., SCARAMELLA, Roberto, Schneider, P., Schrabback, T., Scottez, V., Secroun, A., Serrano, S., Sirignano, C., Sirri, G., AURICCHIO, NATALIA, Stanco, L., Starck, J. -L., Sureau, F., Tallada-Crespí, P., Taylor, A., Tenti, M., Tereno, I., Toledo-Moreo, R., Torradeflot, F., Tutusaus, I., Baldi, M., VALENZIANO, LUCA, Vannier, M., Vassallo, T., Zoubian, J., ZUCCA, Elena, BARDELLI, Sandro, Biviano, A., BONINO, Donata, Borsato, E., Bozzo, E., Branchini, Enzo Franco, Brau-Nogue, S., BRESCIA, Massimo, Brinchmann, J., BURIGANA, CARLO, Camera, S., Capobianco, Vito, CARBONE, Carmelita, Carretero, J., Casas, S., Castander, F. J., CASTELLANO, MARCO, CAVUOTI, STEFANO, Charles, Y., Cledassou, R., Colodro-Conde, C., Congedo, G., Conselice, C., Conversi, L., Copin, Y., Coupon, J., Courtois, H. M., Da Silva, A., Dupac, X., Fabbian, G., Farrens, S., Ferreira, P. G., Fosalba, P., Fourmanoit, N., FRAILIS, Marco, Fumana, M., GALEOTTA, Samuele, GARILLI, BIANCA MARIA ROSA, Gillard, W., Gillis, B. R., Giocoli, C., Graciá-Carpio, J., Grupp, F., Hormuth, F., Ilić, S., Israel, H., Jahnke, K., Keihanen, E., Kermiche, S., Kilbinger, M., Kirkpatrick, C. C., Kubik, B., Kunz, M., Kurki-Suonio, H., Lacasa, F., Laureijs, R., Le Mignant, D., LIGORI, Sebastiano, Lilje, P. B., Lloro, I., Maciaszek, T., MAIORANO, Elisabetta, Marggraf, O., Markovic, K., Martinelli, M., Martinet, N., Marulli, F., Massey, R., Mauri, N., MEDINACELI VILLEGAS, EDUARDO, Mei, S., Mellier, Y., MENEGHETTI, MASSIMO, Metcalf, R. B., Moresco, M., Moscardini, L., Munari, E., Neissner, C., Nichol, R. C., Niemi, S., Nutma, T., Padilla, C., Paltani, S., PASIAN, Fabio, Pettorino, V., Pires, S., Astronomy, Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique (LERMA (UMR_8112)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Queen Mary University of London (QMUL), Institut d'Estudis Espacials de Catalunya (IEEC-CSIC), and Euclid Collaboration
Subjects: Physics, COSMIC cancer database, 010308 nuclear & particles physics, Astronomy and Astrophysics, Astrophysics, 01 natural sciences, gravitational lensing: weak, Shear (geology), Space and Planetary Science, 0103 physical sciences, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], 010303 astronomy & astrophysics, addenda, errata
Abstract: International audience; Authors Lacasa, Martinelli, Pourtsidou, Tutusaus, were inadvertently missed from the original authorship list. This is now corrected.
Published: 2020

38. A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease

Author: Harald Hampel, Filippo Caraci, A. Claudio Cuello, Giuseppe Caruso, Robert Nisticò, Massimo Corbo, Filippo Baldacci, Nicola Toschi, Francesco Garaci, Patrizia A. Chiesa, Steven R. Verdooner, Leyla Akman-Anderson, Félix Hernández, Jesús Ávila, Enzo Emanuele, Pedro L. Valenzuela, Alejandro Lucía, Mark Watling, Bruno P. Imbimbo, Andrea Vergallo, Simone Lista, Gestionnaire, Hal Sorbonne Université, Alzheimer Precision Medicine [CHU Pitié-Salpétriêre] (GRC 21 APM), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of Catania [Italy], Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), McGill University = Université McGill [Montréal, Canada], University of Oxford, Università degli Studi di Roma Tor Vergata [Roma], European Brain Research Institute [Rome, Italy] (EBRI), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] (IM2A), Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], University of Pisa - Università di Pisa, Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston], Harvard Medical School [Boston] (HMS), NeuroVision Imaging, Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III [Madrid] (ISC), Universidad de Alcalá - University of Alcalá (UAH), Universidad Europea de Madrid = European University of Madrid (UEM), Hospital Universitario 12 de Octubre [Madrid], Alzheimer Precision Medicine [CHU Pitié-Salpétriêre] (GRC 21 AMP), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University of Oxford [Oxford], Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de la Mémoire et de la Maladie d'Alzheimer [Paris] (IM2A), Sorbonne Université (SU), Service de neurologie 1 [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Massachusetts General Hospital [Boston]-Harvard Medical School [Boston] (HMS), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universidad Europea de Madrid, Sorbonne Université, Fondation pour la Recherche sur Alzheimer, and AXA Research Fund
Subjects: 0301 basic medicine, Proteomics, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Enfermedad del sistema nervioso, microglia, Review, Genética humana, neuroinflammation, Tratamiento médico, 0302 clinical medicine, Enfermedad de Alzheimer, Medicine, Immunology and Allergy, Cell Self Renewal, Terapeútica, Antiinflammatory therapy, Microglia, Neurodegeneration, Settore BIO/14, systems biology, Alzheimer's disease, 3. Good health, medicine.anatomical_structure, Cytokines, [SDV.IMM]Life Sciences [q-bio]/Immunology, Neurogenic Inflammation, Alzheimer’s disease, Signal Transduction, lcsh:Immunologic diseases. Allergy, [SDV.IMM] Life Sciences [q-bio]/Immunology, Systems biology, precision medicine, Immunology, anti-inflammatory therapy, biomarkers, neuroinflammatory pathways, Proinflammatory cytokine, 03 medical and health sciences, Alzheimer Disease, Animals, Humans, Neuroinflammation, business.industry, TREM2, Mechanism (biology), [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, medicine.disease, Precision medicine, Lipid Metabolism, 030104 developmental biology, business, lcsh:RC581-607, Neuroscience, 030215 immunology, Genome-Wide Association Study
Abstract: Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and represents one of the earliest pathomechanistic alterations throughout the AD continuum. Large-scale genome-wide association studies point out several genetic variants—TREM2, CD33, PILRA, CR1, MS4A, CLU, ABCA7, EPHA1, and HLA-DRB5-HLA-DRB1—potentially linked to neuroinflammation. Most of these genes are involved in proinflammatory intracellular signaling, cytokines/interleukins/cell turnover, synaptic activity, lipid metabolism, and vesicle trafficking. Proteomic studies indicate that a plethora of interconnected aberrant molecular pathways, set off and perpetuated by TNF-α, TGF-β, IL-1β, and the receptor protein TREM2, are involved in neuroinflammation. Microglia and astrocytes are key cellular drivers and regulators of neuroinflammation. Under physiological conditions, they are important for neurotransmission and synaptic homeostasis. In AD, there is a turning point throughout its pathophysiological evolution where glial cells sustain an overexpressed inflammatory response that synergizes with amyloid-β and tau accumulation, and drives synaptotoxicity and neurodegeneration in a self-reinforcing manner. Despite a strong therapeutic rationale, previous clinical trials investigating compounds with anti-inflammatory properties, including non-steroidal anti-inflammatory drugs (NSAIDs), did not achieve primary efficacy endpoints. It is conceivable that study design issues, including the lack of diagnostic accuracy and biomarkers for target population identification and proof of mechanism, may partially explain the negative outcomes. However, a recent meta-analysis indicates a potential biological effect of NSAIDs. In this regard, candidate fluid biomarkers of neuroinflammation are under analytical/clinical validation, i.e., TREM2, IL-1β, MCP-1, IL-6, TNF-α receptor complexes, TGF-β, and YKL-40. PET radio-ligands are investigated to accomplish in vivo and longitudinal regional exploration of neuroinflammation. Biomarkers tracking different molecular pathways (body fluid matrixes) along with brain neuroinflammatory endophenotypes (neuroimaging markers), can untangle temporal–spatial dynamics between neuroinflammation and other AD pathophysiological mechanisms. Robust biomarker–drug codevelopment pipelines are expected to enrich large-scale clinical trials testing new-generation compounds active, directly or indirectly, on neuroinflammatory targets and displaying putative disease-modifying effects: novel NSAIDs, AL002 (anti-TREM2 antibody), anti-Aβ protofibrils (BAN2401), and AL003 (anti-CD33 antibody). As a next step, taking advantage of breakthrough and multimodal techniques coupled with a systems biology approach is the path to pursue for developing individualized therapeutic strategies targeting neuroinflammation under the framework of precision medicine., Sorbonne University Foundation and sponsored by la Fondation pour la Recherche sur Alzheimer. HH is an employee of Eisai Inc. During his previous work (until April 2019), he was supported by the AXA Research Fund, the Fondation partenariale Sorbonne Université and the Fondation pour la Recherche sur Alzheimer, Paris, France
Published: 2020

39. Impact of simulated Martian conditions on (facultatively) anaerobic bacterial strains from different Mars analogue sites

Author: Beblo-Vranesevic, Kristina, Bohmeier, Maria, Schleumer, Sven, Rabbow, Elke, Perras, Alexandra K., Moissl-Eichinger, Christine, Schwendner, Petra, Cockell, Charles S., Vannier, Pauline, Marteinsson, Viggo T., Monaghan, Euan P., Riedo, Andreas, Ehrenfreund, Pascale, Garcia-Descalzo, Laura, Gómez, Felipe, Malki, Moustafa, Amils, Ricardo, Gaboyer, Frédéric, Hickman-Lewis, Keyron, Westall, Frances, Cabezas, Patricia, Walter, Nicolas, Rettberg, Petra, Deutsches Zentrum für Luft- und Raumfahrt [Köln] (DLR), DLR Institut für Luft- und Raumfahrtmedizin, Medical University Graz, UK Centre for Astrobiology, SUPA School of Physics and Astronomy [Edinburgh], University of Edinburgh-University of Edinburgh, Laboratoire de microbiologie des environnements extrêmophiles (LM2E), Centre National de la Recherche Scientifique (CNRS)-Université de Brest (UBO)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), MATIS - Prokaria, Leiden Observatory [Leiden], Universiteit Leiden [Leiden], Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), European Science Foundation (ESF), Rettberg, P. [0000-0003-4439-2395], García Descalzo, L. [0000-0002-0083-6786], Cabezas, P. [0000-0002-6336-4093], Marteinsson, V. [0000-0001-8340-821X], Gómez, F. [0000-0001-9977-7060], and Antunes, André
Subjects: Time Factors, Extraterrestrial Environment, Cell Survival, Firmicutes, Mars, Anaerobic Bacterial, Radiation Tolerance, Bacteria, Anaerobic, Strahlenbiologie, Enterobacteriaceae, Stress, Physiological, MASE, Carnobacteriaceae, Desiccation, Clostridium, Perchlorates, simulated Martian conditions, Martian conditions, anearobic bacterial strains, Sodium Compounds, Yersinia, Oxidative Stress, 13. Climate action, [SDU]Sciences of the Universe [physics], Simulated, Extreme Environments
Abstract: Five bacterial (facultatively) anaerobic strains, namely Buttiauxella sp. MASE-IM-9, Clostridium sp. MASE-IM-4, Halanaerobium sp. MASE-BB-1, Trichococcus sp. MASE-IM-5, and Yersinia intermedia MASE-LG-1 isolated from different extreme natural environments were subjected to Mars relevant environmental stress factors in the laboratory under controlled conditions. These stress factors encompassed low water activity, oxidizing compounds, and ionizing radiation. Stress tests were performed under permanently anoxic conditions. The survival rate after addition of sodium perchlorate (Na-perchlorate) was found to be species-specific. The inter-comparison of the five microorganisms revealed that Clostridium sp. MASE-IM-4 was the most sensitive strain (D10-value (15 min, NaClO4) = 0.6 M). The most tolerant microorganism was Trichococcus sp. MASE-IM-5 with a calculated D10-value (15 min, NaClO4) of 1.9 M. Cultivation in the presence of Na-perchlorate in Martian relevant concentrations up to 1 wt% led to the observation of chains of cells in all strains. Exposure to Na-perchlorate led to a lowering of the survival rate after desiccation. Consecutive exposure to desiccating conditions and ionizing radiation led to additive effects. Moreover, in a desiccated state, an enhanced radiation tolerance could be observed for the strains Clostridium sp. MASE-IM-4 and Trichococcus sp. MASE-IM-5. These data show that anaerobic microorganisms from Mars analogue environments can resist a variety of Martian-simulated stresses either individually or in combination. However, responses were species-specific and some Mars-simulated extremes killed certain organisms. Thus, although Martian stresses would be expected to act differentially on microorganisms, none of the expected extremes tested here and found on Mars prevent the growth of anaerobic microorganisms., With funding from the Spanish government through the "María de Maeztu Unit of Excellence" accreditation (MDM-2017-0737)
Published: 2020

40. From pulsatile apicomedial contractility to effective epithelial mechanics

Author: Guy B. Blanchard, Jocelyn Etienne, Nicole Gorfinkiel, Dept of Physiology, Development and Neurosciences, Anatomy building, University of Cambridge, Anatomy building, University of Cambridge, LIPHY-DYFCOM, Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères] (LIPhy), Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Blanchard, Guy [0000-0002-3689-0522], Apollo - University of Cambridge Repository, and Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], Pulsatile flow, Context (language use), [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], macromolecular substances, Myosins, Biology, Epithelium, Biomechanical Phenomena, [PHYS.MECA.MEMA]Physics [physics]/Mechanics [physics]/Mechanics of materials [physics.class-ph], Contractility, 03 medical and health sciences, 0302 clinical medicine, Células, Myosin, Genetics, Humans, [PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph], ComputingMilieux_MISCELLANEOUS, Actin, Biología celular, Biomechanics, [SDV.BDD.MOR]Life Sciences [q-bio]/Development Biology/Morphogenesis, Histología, Actomyosin, Mechanics, Actins, 030104 developmental biology, 030217 neurology & neurosurgery, Developmental Biology
Abstract: We review recent developments in the understanding of the biomechanics of apicomedial actomyosin and how its contractility can tense and deform tissue. Myosin pulses are driven by a biochemical oscillator but how they are modulated by the mechanical context remains unclear. On the other hand, the emergence of tissue behaviour is highly dependent on the material properties of actin, on how strongly components are connected and on the influence of neighbouring tissues. We further review the use of constitutive equations in exploring the mechanics of epithelial apices dominated by apicomedial Myosin contractility. Sin financiación 5.288 JCR (2018) Q1, 22/174 Genetics & Heredity, 47/193 Cell Biology 3.954 SJR (2018) Q1, 5/87 Developmental Biology, 18/351 Genetics No data IDR 2018 UEM
Published: 2018

41. Cell Biology of T Cell Receptor Expression and Regulation

Author: Balbino Alarcón, Andrés Alcover, Vincenzo Di Bartolo, Biologie Cellulaire des Lymphocytes - Lymphocyte Cell Biology, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris], Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: MESH: Signal Transduction, 0301 basic medicine, MESH: CD3 Complex, CD3 Complex, T-Lymphocytes, recycling, MESH: Structure-Activity Relationship, Immunology and Allergy, MESH: Animals, biology, MESH: Receptors, Antigen, T-Cell, MESH: Gene Expression Regulation, Endocytosis, 3. Good health, Cell biology, medicine.anatomical_structure, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, TCR-CD3, MESH: Endocytosis, Signal transduction, signaling, Signal Transduction, assembly, Endosome, T cell, Immunology, MESH: Immunomodulation, Receptors, Antigen, T-Cell, MESH: Proteolysis, Endosomes, Major histocompatibility complex, Immunomodulation, Structure-Activity Relationship, 03 medical and health sciences, conformational change, Antigen, medicine, Animals, Humans, MESH: Humans, Cell Membrane, T-cell receptor, MESH: Multiprotein Complexes, MESH: T-Lymphocytes, 030104 developmental biology, Gene Expression Regulation, MESH: Endosomes, Multiprotein Complexes, Proteolysis, MESH: Biomarkers, biology.protein, Biomarkers, MESH: Cell Membrane
Abstract: International audience; T cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains that recognize peptide antigens associated with major histocompatibility complex molecules expressed on the surface of antigen-presenting cells. TCRαβ subunits are associated with the CD3 complex formed by the γ, δ, ε, and ζ subunits, which are invariable and ensure signal transduction. Here, we review how the expression and function of TCR complexes are orchestrated by several fine-tuned cellular processes that encompass (a) synthesis of the subunits and their correct assembly and expression at the plasma membrane as a single functional complex, (b) TCR membrane localization and dynamics at the plasma membrane and in endosomal compartments, (c) TCR signal transduction leading to T cell activation, and (d) TCR degradation. These processes balance each other to ensure efficient T cell responses to a variety of antigenic stimuli while preventing autoimmunity.
Published: 2018

42. Arabidopsis ALIX regulates stomatal aperture and turnover of Abscisic acid receptors

Author: Laurent Nussaume, Vicente Rubio, Javier Paz-Ares, Pedro L. Rodriguez, Angel M. Zamarreño, Marta García-León, Nathalie Leonhardt, Laura Cuyas, Lesia Rodriguez, Diaa Abd El-Moneim, Y. Fernández, José María García-Mina, Eva Sanchez-Quant, Borja Belda-Palazón, Brice Roux, Centro Nacional de Biotecnología [Madrid] (CNB-CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Plant Environmental Physiology and Stress Signaling (PEPSS), Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) (BIAM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Universitat Politècnica de València (UPV), Universidad de Navarra [Pamplona] (UNAV), ANR-13-ADAP-0008,Reglisse,Régulation de l'interconversion des glycérolipides chez les plantes en réponse aux variations environnementales(2013), Centro Nacional de Biotecnologia (CNB), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Signalisation de l'Adaptation des Végétaux à l'Environnement (SAVE), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Agence Nationale de la Recherche (France), Ministerio de Educación (España), Generalitat Valenciana, EMBO, and Biologie végétale et microbiologie environnementale - UMR7265 (BVME)
Subjects: 0106 biological sciences, 0301 basic medicine, ABA receptor, Endosome, [SDV]Life Sciences [q-bio], Plant Science, Sorting complex, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Arabidopsis, Multivesicular body pathway, BIOQUIMICA Y BIOLOGIA MOLECULAR, Deubiquitinating enzyme AMSH3, Arabidopsis thaliana, Escrt-III, Receptor, Abscisic acid, Late endosome, ComputingMilieux_MISCELLANEOUS, Pyrabactin, biology, Ubiquitin, Protein, organic chemicals, fungi, food and beverages, Cell Biology, Vacuole biogenesis, biology.organism_classification, 3. Good health, Cell biology, 030104 developmental biology, chemistry, FYVE domain, Plasma-Membrane, Intracellular trafficking, 010606 plant biology & botany
Abstract: [EN] The plant endosomal trafficking pathway controls the abundance of membrane-associated soluble proteins, as shown for abscisic acid (ABA) receptors of the PYRABACTIN RESISTANCE1/PYR1-LIKE/REGULATORY COMPONENTS OF ABA RECEPTORS (PYR/PYL/RCAR) family. ABA receptor targeting for vacuolar degradation occurs through the late endosome route and depends on FYVE DOMAIN PROTEIN REQUIRED FOR ENDOSOMAL SORTING1 (FYVE1) and VACUOLAR PROTEIN SORTING23A (VPS23A), components of the ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT-I (ESCRT-I) complexes. FYVE1 and VPS23A interact with ALG-2 INTERACTING PROTEIN-X (ALIX), an ESCRT-III-associated protein, although the functional relevance of such interactions and their consequences in cargo sorting are unknown. In this study we show that Arabidopsis (Arabidopsis thaliana) ALIX directly binds to ABA receptors in late endosomes, promoting their degradation. Impaired ALIX function leads to altered endosomal localization and increased accumulation of ABA receptors. In line with this activity, partial loss-of-function alix-1 mutants display ABA hypersensitivity during growth and stomatal closure, unveiling a role for the ESCRT machinery in the control of water loss through stomata. ABA-hypersensitive responses are suppressed in alix-1 plants impaired in PYR/PYL/RCAR activity, in accordance with ALIX affecting ABA responses primarily by controlling ABA receptor stability. ALIX-1 mutant protein displays reduced interaction with VPS23A and ABA receptors, providing a molecular basis for ABA hypersensitivity in alix-1 mutants. Our findings unveil a negative feedback mechanism triggered by ABA that acts via ALIX to control the accumulation of specific PYR/PYL/RCAR receptors., This research was supported by the Ministerio de Economia y Competitividad (MINECO) and AEI/FEDER/EU (grants BIO2013-46539-R and BIO2016-80551-R to V.R., and BIO2017-82503-R to P.L.R.); by the Spanish Ministry of Education FPI "Severo Ochoa" fellowships (BES2015071820 to M.G.-L.); by the European Molecular Biology Organization (EMBO) Short-Term programs (ASTF 7678-2016); by the Agence Nationale de Recherche REGLISSE project (ANR-13-ADAP-0008 to L.C.); by an Agencia Espanola de Cooperacion Internacional (AECID) fellowship to D.A.E.-M.; by the Spanish Ministry of Education "Salvador de Madariaga" grant (PRX15/00493 to V.R.); and by Generalitat Valenciana "Programa VALi+d" (APOSTD/2017/039 to B.B.P.). We are thankful to Erika Isono for helpful discussion of the article. We thank Qi Xie for the anti-PYL4 antibody, and Oscar Lorenzo for cra1 seeds. We also thank the confocal microscopy, in vitro plant culture, and greenhouse facilities at the CNB-CSIC for technical support.
Published: 2019

43. Cooperation of axial and sex specific information controls Drosophila female genitalia growth by regulating the Decapentaplegic pathway

Author: Ernesto Sánchez-Herrero, Jesús Romero-Pozuelo, Samir Merabet, David Foronda, Bruno Hudry, Yacine Graba, Paloma Martín, Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institute of Clinical Sciences, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Institut de Génomique Fonctionnelle de Lyon (IGFL), École normale supérieure - Lyon (ENS Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Imperial College London, École normale supérieure de Lyon (ENS de Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Centro de Biología Molecular Severo Ochoa, Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Aix Marseille Université (AMU)-Collège de France (CdF)-Centre National de la Recherche Scientifique (CNRS), CNRS, UMR5242, Inst Genom Fonctionnelle Lyon,Ecole Normale Super, and Université de Lyon
Subjects: Gene isoform, animal structures, [SDV]Life Sciences [q-bio], Doublesex, Gene regulatory network, Morphogenesis, Embryonic Development, Genes, Insect, Biology, Regulatory Sequences, Nucleic Acid, 03 medical and health sciences, 0302 clinical medicine, Animals, Drosophila Proteins, Enhancer, Hox gene, Molecular Biology, Transcription factor, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Homeodomain Proteins, 0303 health sciences, Decapentaplegic, Genes, Homeobox, Gene Expression Regulation, Developmental, Nuclear Proteins, Cell Biology, Genitalia, Female, Cell biology, DNA-Binding Proteins, Drosophila, Female, 030217 neurology & neurosurgery, Developmental Biology, Transcription Factors
Abstract: The specification and morphogenesis of an organ requires the coordinate deployment and integration of regulatory information, including sex specific information when the organ is sex specific. Only a few gene networks controlling size and pattern development have been deciphered, which limits the emergence of principles, general or not, underlying the organ-specifying gene networks. Here we elucidate the genetic and molecular network determining the control of size in the Drosophila abdominal A9 primordium, contributing to the female genitalia. This network requires axial regulatory information provided by the Hox protein Abdominal-BR (Abd-BR), the Hox cofactors Extradenticle (Exd) and Homothorax (Hth), and the sex specific transcription factor Doublesex Female (DsxF). These factors synergize to control size in the female A9 by the coordinate regulation of the Decapentaplegic (Dpp) growth pathway. Molecular dissection of the dpp regulatory region and in vivo protein interaction experiments suggest that Abd-BR, Exd, Hth and DsxF coordinately regulate a short dpp enhancer to repress dpp expression and restrict female A9 size. The same regulators can also suppress dpp expression in the A8, but this requires the absence of the Abd-BM isoform, which specifies A8. These results delineate the network controlling female A9 growth in Drosophila.
Published: 2019

44. Microbial Markers Profile in Anaerobic MarsAnalogue Environments Using the LDChip(Life Detector Chip) Antibody Microarray Coreof the SOLID (Signs of Life Detector) Platform

Author: Ricardo Amils, Elke Rabbow, Patricia Cabezas, Petra Rettberg, L. Garcia-Descalzo, Pauline Vannier, Nicolas Walter, Kristina Beblo-Vranesevic, Viggo Marteinsson, Maria Bohmeier, Pascale Ehrenfreund, Miriam García-Villadangos, E. Monaghan, Andreas Riedo, Christine Moissl-Eichinger, Felipe Gómez, Frederik Gaboyer, Charles S. Cockell, M. Malki, Alex Perras, Frances Westall, Victorino Parro, Centro de Astrobiologia [Madrid] (CAB), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), Planetary and Space Sciences Research Institute [Milton Keynes] (PSSRI), Centre for Earth, Planetary, Space and Astronomical Research [Milton Keynes] (CEPSAR), The Open University [Milton Keynes] (OU)-The Open University [Milton Keynes] (OU), Medical University Graz, DLR Institut für Luft- und Raumfahrtmedizin, Deutsches Zentrum für Luft- und Raumfahrt [Köln] (DLR), Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Matis Ohf Food Safety Environm & Genet, Laboratoire de microbiologie des environnements extrêmophiles (LM2E), Centre National de la Recherche Scientifique (CNRS)-Université de Brest (UBO)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Space Policy Institute [Washington], The George Washington University (GW), Leiden Observatory [Leiden], Universiteit Leiden [Leiden], Georgetown University [Washington] (GU), European Science Foundation (ESF), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), Westall, Frances, Matvæla- og næringarfræðideild (HÍ), Faculty of Food Science and Nutrition (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, and European Commission
Subjects: Microbiology (medical), 010504 meteorology & atmospheric sciences, Antibody microarray, Analogues, [SDV]Life Sciences [q-bio], Mars, Computational biology, Microarray, 01 natural sciences, Microbiology, Environmental stress, Article, [SDU] Sciences of the Universe [physics], Strahlenbiologie, Virology, 0103 physical sciences, Microarray platform, 010303 astronomy & astrophysics, lcsh:QH301-705.5, 0105 earth and related environmental sciences, anaerobic environments, Örverufræði, Mars (reikistjarna), Detector, biomarkers, Mars Exploration Program, Halophilic microorganisms, 3. Good health, [SDV] Life Sciences [q-bio], lcsh:Biology (General), 13. Climate action, [SDU]Sciences of the Universe [physics], Anaerobic environments, Environmental science, analogues, microarray, Biomarkers
Abstract: Publisher's version (útgefin grein), One of the main objectives for astrobiology is to unravel and explore the habitability of environments beyond Earth, paying special attention to Mars. If the combined environmental stress factors on Mars are compatible with life or if they were less harsh in the past, to investigate the traces of past or present life is critical to understand its potential habitability. Essential for this research is the characterization of Mars analogue environments on Earth through the development of techniques for biomarker detection in them. Biosensing techniques based on fluorescence sandwich microarray immunoassays (FSMI) have shown to be a powerful tool to detect biosignatures and depict the microbial profiles of different environments. In this study, we described the microbial biomarker profile of five anoxic Mars analogues sites using the Life Detector Chip (LDChip), an antibody microarray for multiple microbial marker detection. Furthermore, we contributed to new targets by developing a new 26-polyclonal antibodies microarray using crude extracts from anaerobic sampling sites, halophilic microorganisms, and anaerobic isolates obtained in the framework of the European Mars Analogues for Space Exploration (MASE) project. The new subset of antibodies was characterized and implemented into a microarray platform (MASE-Chip) for microbial marker searching in salty and anaerobic environments., MASE is supported by European Community’s Seventh Framework Program (FP7/2007–2013) under Grant Agreement N° 607297.
Published: 2019

45. A standardized nomenclature and atlas of the male terminalia of Drosophila melanogaster

Author: Stéphane Noselli, Ernesto Sánchez-Herrero, Patrick M. O’Grady, Yoshitaka Kamimura, Virginie Courtier-Orgogozo, John P. Masly, Masanori J. Toda, Olga Nagy, Mark L. Siegal, Mark Rebeiz, Maria D. S. Nunes, Amir Yassin, Alistair P. McGregor, Gavin R. Rice, Jean R. David, Department of Computer Science - University of Pittsburgh, University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE)-Pennsylvania Commonwealth System of Higher Education (PCSHE), Évolution, génomes, comportement et écologie (EGCE), Centre National de la Recherche Scientifique (CNRS)-IRD-Université Paris-Sud - Paris 11 (UP11), Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), Department of Biological Sciences [Pittsburgh], Carnegie Mellon University [Pittsburgh] (CMU), Université Paris-Sud - Paris 11 (UP11)-IRD-Centre National de la Recherche Scientifique (CNRS), DEPARTMENT OF BIOLOGY UNIVERSITY OF OKLAHOMA NORMAN USA, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Department of Biological and Medical Sciences, Oxford Brookes University, Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Center for Genomics and Systems Biology, Department of Biology [New York], New York University [New York] (NYU), NYU System (NYU)-NYU System (NYU)-New York University [New York] (NYU), NYU System (NYU)-NYU System (NYU), Hokkaido University Museum, Hokkaido University [Sapporo, Japan], ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI (2016), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), and Muséum national d'Histoire naturelle (MNHN)-École Pratique des Hautes Études (EPHE)
Subjects: Male, Future studies, anatomy, [SDV]Life Sciences [q-bio], Anatomical structures, Genitalia, Male, entomology, Brief Communication, Terminology, 03 medical and health sciences, 0302 clinical medicine, Terminology as Topic, medicine, Animals, Interdisciplinary communication, Genitalia, Nomenclature, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Confusion, Cognitive science, 0303 health sciences, biology, terminalia, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Terminalia, biology.organism_classification, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, Drosophila melanogaster, Insect Science, nomenclature, medicine.symptom, 030217 neurology & neurosurgery
Abstract: International audience; Animal terminalia represent some of the most diverse and rapidly evolving structures in the animal kingdom, and for this reason have been a mainstay in the taxonomic description of species. The terminalia of Drosophila melanogaster, with its wide range of experimental tools, have recently become the focus of increased interest in the fields of development, evolution, and behavior. However, studies from different disciplines have often used discrepant terminologies for the same anatomical structures. Consequently, the terminology of genital parts has become a barrier to integrating results from different fields, rendering it difficult to determine what parts are being referenced. We formed a consortium of researchers studying the genitalia of D. melanogaster to help establish a set of naming conventions. Here, we present a detailed visual anatomy of male genital parts, including a list of synonymous terms, and suggest practices to avoid confusion when referring to anatomical parts in future studies. The goal of this effort is to facilitate interdisciplinary communication and help newcomers orient themselves within the exciting field of Drosophila genitalia. ARTICLE HISTORY
Published: 2019

46. Approximation of Lipschitz functions preserving boundary values

Author: Robert Deville, Carlos Mudarra, Ministerio de Economía y Competitividad (España), Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), Instituto de Ciencias Matematicas (ICMAT), and Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: Pure mathematics, Control and Optimization, Lipschitz function, 0211 other engineering and technologies, Open set, Banach space, Mathematics::Analysis of PDEs, 010103 numerical & computational mathematics, 02 engineering and technology, Management Science and Operations Research, [MATH.MATH-FA]Mathematics [math]/Functional Analysis [math.FA], 01 natural sciences, FOS: Mathematics, Almost everywhere, Differentiable function, 0101 mathematics, Mathematics - Optimization and Control, ComputingMilieux_MISCELLANEOUS, Normed vector space, Mathematics, Almost classical solution, 021103 operations research, Eikonal equation, Applied Mathematics, Lipschitz continuity, Functional Analysis (math.FA), Mathematics - Functional Analysis, Optimization and Control (math.OC), Norm (mathematics), Smooth approximation
Abstract: Given an open subset of a Banach space and a Lipschitz real-valued function defined on its closure, we study whether it is possible to approximate this function uniformly by Lipschitz functions having the same Lipschitz constant and preserving the values of the initial function on the boundary of the open set, and which are k times continuously differentiable on the open. A consequence of our result is that every 1-Lipschitz function defined on the closure of an open subset of a finite-dimensional normed space of dimension greater than one, and such that the Lipschitz constant of its restriction to the boundary is less than 1, can be uniformly approximated by differentiable 1-Lipschitz functions preserving the values of the initial function on the boundary of the open set, and such that its derivative has norm one almost everywhere on the open. This result does not hold in general without assumption on the Lipschitz constant of the restriction of the initial function to the boundary., We wish to thank the referee for several suggestions that improved the exposition. C. Mudarra wishes to thank the Institut de Mathématiques de Bordeaux, where this work was carried out. R. Deville was supported by the Grants: ECOS/SUD C14E06 (France) and REDES/CONICYT-150040 (Chile). C. Mudarra was supported by the Grants: Programa Internacional de Doctorado Fundación La Caixa–Severo Ochoa (Spain) and MTM2015-65825-P MINECO (Spain) Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Published: 2019

47. Interplay between SUMOylation and NEDDylation regulates RPL11 localization and function

Author: Carmen Rivas, Rune Matthiesen, Sabela Da Silva-Álvarez, Manuel Collado, Ahmed El Motiam, Ana Sofia Carvalho, Hans Christian Beck, Carlos F. de la Cruz-Herrera, Maite Baz-Martínez, Anxo Vidal, Dimitris P. Xirodimas, Santiago Vidal, Rocío Seoane, Manuel S. Rodriguez, Molecular Medicine and Chronic Diseases Research Centre [Santiago de Compostela, Spain] (CIMUS), Universidade de Santiago de Compostela [Spain] (USC ), Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en Biologie Cellulaire (CRBM), Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School - Faculdade de Ciências Médicas (NMS), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Department of Clinical Biochemistry and Pharmacology, OdenseUniversity Hospital, Sdr. Boulevard 29, CIMUS Biomedical Research Institute [Santiago de Compostela], Centro Nacional de Biotecnología [Madrid] (CNB-CSIC), Biocomputing Unit [Madrid], Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, Department of Molecular Genetics, University of Toronto, University of Toronto, Hospital Clínico Universitario Santiago de Compostela, Institut des Technologies Avancées en sciences du Vivant (ITAV), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut de pharmacologie et de biologie structurale (IPBS), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université Montpellier 2 - Sciences et Techniques (UM2), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Odense University Hospital, Odense, Molecular and Cellular Biology, Hospital Clinico Universitario de Santiago de Compostela, Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Instituto de Investigación Sanitaria de Santiago de Compostela / Health Research Institute of Santiago de Compostela (IDIS), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en Biologie cellulaire de Montpellier (CRBM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Ribosomal Proteins, 0301 basic medicine, p53, NEDD8 Protein, Nucleolus, [SDV]Life Sciences [q-bio], SUMO protein, Regulator, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, SUMO2, Biochemistry, NEDD8, environment and public health, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Ribosomal protein, Neoplasms, Tumor Cells, Cultured, Genetics, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Ubiquitins, Molecular Biology, ComputingMilieux_MISCELLANEOUS, Chemistry, Sumoylation, ARF, Cell biology, HEK293 Cells, 030104 developmental biology, SUMO, Small Ubiquitin-Related Modifier Proteins, Neddylation, Protein Processing, Post-Translational, 030217 neurology & neurosurgery, Biotechnology
Abstract: The ribosomal protein L11 (RPL11) integrates different types of stress into a p53-mediated response. Here, we analyzed the impact of the ubiquitin-like protein SUMO on the RPL11-mouse double-minute 2 homolog-p53 signaling. We show that small ubiquitin-related modifier (SUMO)1 and SUMO2 covalently modify RPL11. We find that SUMO negatively modulates the conjugation of the ubiquitin-like protein neural precursor cell-expressed developmentally downregulated 8 (NEDD8) to RPL11 and promotes the translocation of the RP outside of the nucleoli. Moreover, the SUMO-conjugating enzyme, Ubc9, is required for RPL11-mediated activation of p53. SUMOylation of RPL11 is triggered by ribosomal stress, as well as by alternate reading frame protein upregulation. Collectively, our data identify SUMO protein conjugation to RPL11 as a new regulator of the p53-mediated cellular response to different types of stress and reveal a previously unknown SUMO-NEDD8 interplay.-El Motiam, A, Vidal, S., de la Cruz-Herrera, C. F., Da Silva-Álvarez, S., Baz-Martínez, M., Seoane, R., Vidal, A., Rodríguez, M. S., Xirodimas, D. P., Carvalho, A. S., Beck, H. C., Matthiesen, R., Collado, M., Rivas, C. Interplay between SUMOylation and NEDDylation regulates RPL11 localization and function.
Published: 2019

48. On Non-commutative Stochastic Exponentials

Author: Charles Curry, Kurusch Ebrahimi-Fard, Frédéric Patras, Instituto de Ciencias Matematicas (ICMAT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire Jean Alexandre Dieudonné (JAD), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 010104 statistics & probability, Pure mathematics, Mathematics::Probability, Magnus expansion, 010102 general mathematics, [MATH.MATH-RA]Mathematics [math]/Rings and Algebras [math.RA], 0101 mathematics, 01 natural sciences, Commutative property, ComputingMilieux_MISCELLANEOUS, Exponential function, Mathematics, Shuffle algebra
Abstract: Using non-commutative shuffle algebra, we outline how the Magnus expansion allows to define explicit stochastic exponentials for matrix-valued continuous semimartingales and Stratonovich integrals.
Published: 2019

49. Semiclassical asymptotics for nonselfadjoint harmonic oscillators

Author: Victor Arnaiz, Gabriel Rivière, Instituto de Ciencias Matematicas (ICMAT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire de Mathématiques Jean Leray (LMJL), Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN), and Ministerio de Economía y Competitividad (España)
Subjects: Harmonic oscillators, Semiclassical analysis, FOS: Physical sciences, Semiclassical physics, Ocean Engineering, 01 natural sciences, Mathematics - Spectral Theory, Resolvent estimates, Mathematics - Analysis of PDEs, integrable systems, [MATH.MATH-MP]Mathematics [math]/Mathematical Physics [math-ph], 35P20, 0103 physical sciences, FOS: Mathematics, Geometric control, nonselfadjoint operators, [MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP], 0101 mathematics, Spectral Theory (math.SP), Mathematical Physics, Harmonic oscillator, Mathematical physics, Resolvent, Physics, 010102 general mathematics, 1. No poverty, averaging method, Mathematical Physics (math-ph), 010307 mathematical physics, Complex plane, Analysis of PDEs (math.AP), [MATH.MATH-SP]Mathematics [math]/Spectral Theory [math.SP]
Abstract: We consider nonselfadjoint perturbations of semiclassical harmonic oscillators. Under appropriate dynamical assumptions, we establish some spectral estimates such as upper bounds on the resolvent near the real axis when no geometric control condition is satisfied., Arnáiz was supported by La Caixa, Severo Ochoa ICMAT, International Ph.D. Programme, 2014, and MTM2017-85934-C3-3-P (MINECO, Spain). Rivière was partially supported by the ANR project GERASIC (ANR-13-BS01-0007-01) and the Labex CEMPI (ANR-11-LABX-0007-01)
Published: 2019

50. Active galactic nuclei and their large-scale structure: an eROSITA mock catalogue

Author: Nicolas Clerc, Mara Salvato, Johan Comparat, A. Georgakakis, Francisco Prada, A. Del Moro, Tom Dwelly, Mirko Krumpe, Johannes Buchner, Gang Zhao, Andrea Merloni, Gustavo Yepes, Alexis Finoguenov, Marcella Brusa, Kirpal Nandra, Y. Wang, Tie Liu, Thomas Boller, Comisión Nacional de Investigación Científica y Tecnológica (Chile), Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), Ministerio de Economía, Fomento y Turismo (Chile), German Research Foundation, Ministerio de Economía y Competitividad (España), European Commission, German Centre for Air and Space Travel, Max Planck Institute for Extraterrestrial Physics (MPE), Max-Planck-Gesellschaft, Max-Planck-Institut für Extraterrestrische Physik (MPE), Max-Planck-Institut für Astronomie (MPIA), Max Planck Institute for Solar System Research (MPS), Institut de recherche en astrophysique et planétologie (IRAP), Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS), Key Lab of Computer System and Architecture, Institute of Computing Technology [Beijing] (ICT), Chinese Academy of Sciences [Beijing] (CAS), Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), AUTRES, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Department of Physics, and Comparat J., Merloni A., Salvato M., Nandra K., Boller T., Georgakakis A., Finoguenov A., Dwelly T., Buchner J., Del Moro A., Clerc N., Wang Y., Zhao G., Prada F., Yepes G., Brusa M. , Krumpe M. , Liu, T.
Subjects: Cosmology and Nongalactic Astrophysics (astro-ph.CO), [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], COSMOLOGICAL COEVOLUTION, Astrophysics::High Energy Astrophysical Phenomena, galaxies: active, FOS: Physical sciences, Library science, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, ACOUSTIC-OSCILLATIONS, Categorical grant, OSCILLATION SPECTROSCOPIC SURVEY, SUPERMASSIVE BLACK-HOLES, 0103 physical sciences, Scale structure, AGN, observations [Cosmology], 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, ComputingMilieux_MISCELLANEOUS, Physics, large-scale structure of universe, 010308 nuclear & particles physics, galaxies: active, large-scale structure of Universe, cosmology: observations, Astrophysics - Astrophysics of Galaxies, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy and Astrophysics, 115 Astronomy, Space science, Astrophysics - Astrophysics of Galaxies, GALAXY, HALO OCCUPATION DISTRIBUTION, QUASARS, 13. Climate action, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), cosmology: observations, active [galaxies], LUMINOSITY, Christian ministry, large-scale structure of Universe, [SDU.ASTR.GA]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA], STELLAR MASS, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: In the context of the upcoming SRG/eROSITA survey, we present an N-body simulation-based mock catalogue for X-ray-selected active galactic nucleus (AGN) samples. The model reproduces the observed hard X-ray AGN luminosity function (XLF) and the soft X-ray logN-logS from redshift 0 to 6. The XLF is reproduced to within +/- 5 per cent and the logN-logS to within +/- 20 per cent. We develop a joint X-ray - optical extinction and classification model. We adopt a set of empirical spectral energy distributions to predict observed magnitudes in the UV, optical, and NIR. With the latest eROSITA all sky survey sensitivity model, we create a high-fidelity full-sky mock catalogue of X-ray AGN. It predicts their distributions in right ascension, declination, redshift, and fluxes. Using empirical medium resolution optical spectral templates and an exposure time calculator, we find that 1.1 x 10(6) (4 x 10(5)) fibre-hours are needed to follow-up spectroscopically from the ground the detected X-ray AGN with an optical magnitude 21 < r < 22.8 (22.8 < r < 25) with a 4-m (8-m) class multiobject spectroscopic facility. We find that future clustering studies will measure the AGN bias to the per cent level at redshift z < 1.2 and should discriminate possible scenarios of galaxy-AGN co-evolution. We predict the accuracy to which the baryon acoustic oscillation standard ruler will be measured using X-ray AGN: better than 3 per cent for AGN between redshift 0.5 to 3 and better than 1 per cent using the Ly alpha forest of X-ray QSOs discovered between redshift 2 and 3. eROSITA will provide an outstanding set of targets for future galaxy evolution and cosmological studies.© 2019 The Author(s).Published by Oxford University Press on behalf of the Royal Astronomical Society, JB acknowledges support from the CONICYT-Chile grants Basal-CATA PFB-06/2007 & AFB-170002, FONDECYT Postdoctorados 3160439 and the Ministry of Economy, Development, and Tourism's Millennium Science Initiative through grant IC120009, awarded to The Millennium Institute of Astrophysics, MAS. This research was supported by the DFG cluster of excellence 'Origin and Structure of the Universe'. GY would like to thank MINECO/FEDER for financial support under project grant AYA2015-63810-P. MK acknowledges support from DLR grant 50OR1802. The CosmoSim data base is a service of the Leibniz-Institute for Astrophysics Potsdam (AIP). The MultiDark data base was developed in cooperation with the Spanish MultiDark Consolider Project CSD2009-00064.
Published: 2019

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