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Cell Biology of T Cell Receptor Expression and Regulation
- Source :
- Annual Review of Immunology, Annual Review of Immunology, Annual Reviews, 2018, 36 (1), pp.103-125. ⟨10.1146/annurev-immunol-042617-053429⟩, Annual Review of Immunology, 2018, 36 (1), pp.103-125. ⟨10.1146/annurev-immunol-042617-053429⟩
- Publication Year :
- 2018
- Publisher :
- Annual Reviews, 2018.
-
Abstract
- International audience; T cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains that recognize peptide antigens associated with major histocompatibility complex molecules expressed on the surface of antigen-presenting cells. TCRαβ subunits are associated with the CD3 complex formed by the γ, δ, ε, and ζ subunits, which are invariable and ensure signal transduction. Here, we review how the expression and function of TCR complexes are orchestrated by several fine-tuned cellular processes that encompass (a) synthesis of the subunits and their correct assembly and expression at the plasma membrane as a single functional complex, (b) TCR membrane localization and dynamics at the plasma membrane and in endosomal compartments, (c) TCR signal transduction leading to T cell activation, and (d) TCR degradation. These processes balance each other to ensure efficient T cell responses to a variety of antigenic stimuli while preventing autoimmunity.
- Subjects :
- MESH: Signal Transduction
0301 basic medicine
MESH: CD3 Complex
CD3 Complex
T-Lymphocytes
recycling
MESH: Structure-Activity Relationship
Immunology and Allergy
MESH: Animals
biology
MESH: Receptors, Antigen, T-Cell
MESH: Gene Expression Regulation
Endocytosis
3. Good health
Cell biology
medicine.anatomical_structure
[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology
TCR-CD3
MESH: Endocytosis
Signal transduction
signaling
Signal Transduction
assembly
Endosome
T cell
Immunology
MESH: Immunomodulation
Receptors, Antigen, T-Cell
MESH: Proteolysis
Endosomes
Major histocompatibility complex
Immunomodulation
Structure-Activity Relationship
03 medical and health sciences
conformational change
Antigen
medicine
Animals
Humans
MESH: Humans
Cell Membrane
T-cell receptor
MESH: Multiprotein Complexes
MESH: T-Lymphocytes
030104 developmental biology
Gene Expression Regulation
MESH: Endosomes
Multiprotein Complexes
Proteolysis
MESH: Biomarkers
biology.protein
Biomarkers
MESH: Cell Membrane
Subjects
Details
- ISSN :
- 15453278 and 07320582
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Annual Review of Immunology
- Accession number :
- edsair.doi.dedup.....3fc13929d7a63df4f74bec33f2c3fee8