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1. Immune responses associated with mpox viral clearance in men with and without HIV in Spain: a multisite, observational, prospective cohort study

Author: Alarcón Soto, Yovaninna, Alemany, Andrea, Bailón, Lucía, Benet, Susana, Mitjà, Oriol, Mothe, Beatriz, Paredes, Roger, Sabato, Sofía, Suñer, Clara, Torrano, Pamela, Ubals, Maria, Boreika, Rytis, Brander, Christian, Carabelli, Julieta, Carrillo, Jorge, Gallemí, Marçal, Izquierdo-Useros, Nuria, Molina-Molina, Elisa, Moraes-Cardoso, Igor, Muñoz-Basagoiti, Jordana, Olvera, Alex, Perez-Zsolt, Daniel, Raïch-Regué, Dàlia, Coll, Pep, Fernández, Javier, Mendoza, Adrià, Pérez, Félix, Reguant, Joan, Rivero, Angel, Arando, Maider, Descalzo, Vicente, Néstor Garcia, Jorge, Monforte, Arnau, Álvarez, Patricia, Guedj, Jeremie, Marc, Aurélien, Marks, Michael, Alarcón-Soto, Yovaninna, Grifoni, Alba, Sette, Alessandro, and Moltó, José
Published: 2024
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2. Oral linezolid compared with benzathine penicillin G for treatment of early syphilis in adults (Trep-AB Study) in Spain: a prospective, open-label, non-inferiority, randomised controlled trial

Author: Ubals, Maria, Nadal-Baron, Patricia, Arando, Maider, Rivero, Ángel, Mendoza, Adrià, Descalzo Jorro, Vicent, Ouchi, Dan, Pérez-Mañá, Clara, Álvarez, Marlene, Alemany, Andrea, Hoyos-Mallecot, Yannick, Nunley, Ethan, Lieberman, Nicole A P, Greninger, Alexander L, Galván-Casas, Cristina, Suñer, Clara, G-Beiras, Camila, Paredes, Roger, Rodríguez-Gascón, Alicia, Canut, Andrés, García-Patos, Vicente, Farré, Magí, Marks, Michael, Giacani, Lorenzo, Vall-Mayans, Martí, and Mitjà, Oriol
Published: 2024
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3. Antimicrobial susceptibility of Treponema pallidum subspecies pallidum: an in-vitro study

Author: Tantalo, Lauren C, Lieberman, Nicole A P, Pérez-Mañá, Clara, Suñer, Clara, Vall Mayans, Marti, Ubals, Maria, González-Beiras, Camila, Rodríguez-Gascón, Alicia, Canut, Andrés, González-Candelas, Fernando, Mueller, John, Tapia, Kenneth, Greninger, Alexander L, Giacani, Lorenzo, and Mitjà, Oriol
Published: 2023
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4. Mpox in people with advanced HIV infection: a global case series

Author: Leiro, Viviana, Marchetta, Lucila, Fernandez Pardal, Patricia, Figueroa, María Inés, Cahn, Pedro, Grabmeier-Pfistershammer, Katharina, Libois, Agnes, Liesenborghs, Laurens, Grinsztejn, Beatriz, Schechter, Mauro, dos Santos de Lemos, Alberto, Furtado Costa, Alvaro, Queiroz Rocha, Simone, Valdez Madruga, José, S. Tan, Darrell H., Mishra, Sharmistha, Shah, Shreya, Jorquera, Camila, Castillo, Alberto, Carrión, Mauricio, Cevallos, Nelson, Palich, Romain, Pourcher, Valerie, Rubenstein, Emma, Migaud, Pascal, Boesecke, Christoph, Hoffmann, Christian, Protopapas, Konstantinos, Nozza, Silvia, Cattelan, Anna Maria, Mussini, Cristina, d'Arminio Monforte, Antonella, Cruz Flores, Raúl Adrian, Pérez Barragán, Edgar, Rodríguez Guzmán, Alma Leticia, Ogoina, Dimie, Chika-Igwenyi, Nneka Marian, Chizaram, Onyeaghala, Valverde López, Jenny, García Tello, Angelica, Ubals, Maria, Vall, Martí, Mendoza, Adrià, Suñer, Clara, Clotet, Bonaventura, Bechini, Jordi, Lepe, Jose A, Navarro-Amuedo, M. Dolores, Bernadino, Jose Ignacio, Català, Alba, Tarín Vicente, Eloy José, González Rodríguez, Borja, Rodriguez-Mercader, Sergi, Sánchez-Martinez, Francisca, Cañas-Ruano, Esperanza, Parra-Navarro, Laura, Filén, Finn, Tallón de Lara, Carmen, Braun, Dominique, Piezzi, Vanja, Burkhard, Michael, Kovari, Helen, Mönch, Anja, Dunning, Jake, Simoes, Pedro, Nori, Achyuta, Keegan, Sarah, Thornhill, John P, Apea, Vanessa, Noori, Teymur, Jones, Joyce L., Judson, Seth, Gilliams, Elizabeth A., Hamill, Matthew M., Keruly, Jeanne, Henao Martínez, Andrés F., Lin, Aung, So, Jessica, Davar, Kusha, Villareal, Diana, Tapia Paredes, Miguel, Mitjà, Oriol, Alemany, Andrea, Marks, Michael, Lezama Mora, Jezer I, Rodríguez-Aldama, Juan Carlos, Torres Silva, Mayara Secco, Corral Herrera, Ever Arturo, Crabtree-Ramirez, Brenda, Blanco, José Luis, Girometti, Nicolo, Mazzotta, Valentina, Hazra, Aniruddha, Silva, Macarena, Montenegro-Idrogo, Juan José, Gebo, Kelly, Ghosn, Jade, Peña Vázquez, María Fernanda, Matos Prado, Eduardo, Unigwe, Uche, Villar-García, Judit, Wald-Dickler, Noah, Zucker, Jason, Paredes, Roger, Calmy, Alexandra, Waters, Laura, Galvan-Casas, Cristina, Walmsley, Sharon, and Orkin, Chloe M
Published: 2023
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5. Subcutaneous anti-COVID-19 hyperimmune immunoglobulin for prevention of disease in asymptomatic individuals with SARS-CoV-2 infection: a double-blind, placebo-controlled, randomised clinical trial

Author: Aguilar-Uroz, Adrià, Rosell-García-Ufano, Adrià, Escudero Planas, Adrián, Baelo, Aida, Villahoz Martín, Ainhoa, Moreno López, Alberto, Roldan Ruiz, Alberto, Santana Briongos, Alberto, Tejera Bodas, Alberto, Alonso-Vallés, Alejandro, Fletes-Pérez, Alejandro, Hueso-Mor, Alejandro, Boluda, Alex, Santamaria, Alex, Diestro, Alicia Santos, Revuelta-Álvarez, Almudena, Moreno Moreno, Álvaro, Ortega de Felipe, Ana, Chen-Ye, Ana, Blázquez Valerón, Ana, Rodríguez Pérez, Ana Belén, Tristán Morgalo, Ana Laura, Fernández-Allende, Ana Luisa, Bagán-Trejo, Andrea, Fernández Juan, Andrés, Zalve-Cano, Ángel, Mateo-Martínez, Anna, Galván, Antonio Valero, Egidos-Plaja, Antonio, Jorge, Ariadna, Fraile Torres, Arturo, Pareja Leal, Azahara Maria, Viader Castro, Bárbara, Fernandez Beato, Barbara, Naveira Menchen, Barbara, Martin Poyatos, Beatriz, García-Martínez, Beatriz, Rodrigo Testillano, Belén, Blanco Tejedor, Belen, López Pérez, Blanca, Mencía Hernanz, Blanca, González-Beiras, Camila, Batres, Carlos, Nuñez Garcia, Carmen, Merino-Rodríguez, Carmen, Rodríguez-Gilabert, Carolina, Bonilla Penedo, Celia, Casado Gomez, Christian, Gonzalez Perez, Claudia, Galindo-Tomás, Claudia, Peral Bolaños, Cristina, Blanco-Montes, Cristina, Lupu-Yakovleva, Cristina, Lopez Ruiz, Cristina, Perez Mayoral, Cristina, Fornes, Cristina, Garcia Corrochano, Cristobal, Gallardo Álvarez, Daniel, Navarro Sanz, Daniel, Sanz Barrio, David, Ramet Meseguer, Debora, Vera-Jurado, Edna Margarita, Perez Costa, Eduardo, Bustillos-Sebastian, Eilen Junet, Palomar Casado, Elena, Guerrero, Elena Dorrego, Medina Mateos, Elena, Aragón Gaspar, Elisa Rebeca, Herrero-Vila, Elisabeth, Paez Herrera, Enriqueta, Rojas Powel, Esmeralda, Robres Medialdea, Esther, Vall-Ribalta, Esther, Lopez Perez, Eva, Mihaela Fer, Felicia, Vazquez Ángeles, Fernanda, Tirado Bejarano, Fernando, Prats-Domenech, Ferran, Borràs Martí, Ferran, Ardila-Mejia, Gabriela, Costes, Gèlia, Gómez Arquero, Gema, Flores Mateo, Gemma, Pintos-Morell, Guillem, Mira-Centelles, Helena, Astola Requena, Ignacio, Ortega Martin, Ignacio, Leivas-Gutierrez, Iker, Escribano Valenciano, Irene, Muñoz Gomez, Irene, Ortega, Irina, Montserrat-Lloan, Isabel, Gamboa, Itziar, Rodríguez de Torres de Paul, Jacobo, Cahís, Jordi, Muñoz-Martinez, Jordi, Bermejo, Jorge Iglesias, Cejas López, Joselvis Virginia, Canudas, Josep, García Lucas, Juan Antonio, Martínez-Pino, Juan Carlos, Torres Martínez, Juana, Pujol-Corney, Judit, González Jiménez, Judith, Gurí, Júlia, Labella Martín, Julio, Garcia-Cano, Laia, Perez Plata, Lara Sonsoles, Muñoz Álvaro, Laura, Rodríguez Andrés, Laura, Vega Ruiz, Laura, Cuevas Valiente, Laura, Díaz Rodríguez, Laura, Puigros, Laura, Cristina Piciorang, Lavinia, Escudero, Leticia, Figueroa Caballero, Liliana, Ferrerfàbrega-Costals, Lluna, Costafreda-Hernández, Lucía, De-Paúl, Lucía, González Fernández-Medina, Luis, Moliner Prada, M<ce:sup loc='post">a</ce:sup> Carmen, Berriochoa Martínez de Pisón, M<ce:sup loc='post">a</ce:sup> Cristina, Blanco Blasco, Maria, Gil Jorge, Maria, Cortijo Caballero, María, Ubals, Maria, Gordillo, Maria, Guilloto López, Maria Alicia, Moreno Calvo, Maria Concepción, Gil García, María del Rosario, Dueñas Román, María Inmaculada, Gonzalez Sanchez, Maria Josefa, Nicolás Campoy, María Luisa, González Velayos, Maria Luz, Zori, Mario Mejías, Maqueda, Mario Oliva, Caño de la Cruz, Mario, Palau-Morral, Mariona, Martín-Muñoz, Marta, Cereceda Meca, Marta, Díaz Urbina, Marta, VerónicaPlazas, Martha, Vall-Mayans, Martí, Blasco, Martí, Jane Chu-Sifuentes, Mary, García de Villasladad Peñaranda, Miguel, Hernanz Sotoca, Miguel, Iglesias Gonzalez, Miguel, Labrador-Galván, Miguel Ángel, Rodrigo de Vivar Azcarate, Miguel, Gil-Fibla, Miquel, Formentí-Pallarés, Miquel, Esteve-Tugues, Mireia, Juanes Perez, Miriam, López Rubio, Miriam, Recuero Renales, Mirian, Hijós-Rullo, Mònica, Lleonart-Abadia, Montserrat, Finelli, Nadia, Rojas-Bertier, Naiara, Reyes-Calderón, Nataly, Casado Larrañaga, Nerea, Zurita Castrosin, Nerea Nuria, Álvarez-Nieto, Noélia, Leiva-Mora, Nuria, Tomillo-Martín, Olga, Belghazi, Omar, Buscà, Oriol, Mendoza Cediel, Pablo, Macedo, Pablo, Rodríguez Barroso, Patricia, Ruiz Álvarez, Patricia, López, Patricia Morales, Vara de Rey, Patricia Jimenez, Ginés, Paz Lozano, Bris Rodriguez, Pilar, Martínez-Alamillo, Pilar, Salmerón Martínez, Rafa, Botello Ariza, Raquel, Vaquero Mena, Raquel, González-Alonso, Raquel, Kaczmarczyk, Raul, Barnadas Vintró, Rita, Hontecillas Martínez, Rodrigo, Ribot-Rodríguez, Rosa, Escobar-Sánchez, Rosa, Montes Trinidad, Rosario Paloma, Martínez Quintana, Rubén, Arnay Arrogante, Ruben, Berjon Sanchez, Ruben, Picazo Navarro, Ruben, Bastos, Rubén, Martín Molinero, Samuel, Israel-Benchaya, Samuel Dan, Muñoz-Burguillo, Sandra, Rodríguez-Salvador, Sandra, Avila, Sara, Corral Gayubas, Sara, Nuñez Sánchez, Sergio, Torres Weber, Sofía, Encabo Lopez, Susana, Torices Rasines, Teresa, Sallas, Valentí, Curto-Vicente, Verónica, Gómez Hijosa, Verónica, Daimiel-Pedrote, Verónica, Gozalo, Verónica, Barrios López, Vicente, Castillo Montoya, Virginia Ivette, Espinoza Pérez, Yuri, CristinaBerriochoa Martínez de Pisón, María, Muñoz Castillo, David, Donato, Carlos, García García, Isabel, Alemany, Andrea, Millat-Martinez, Pere, Corbacho-Monné, Marc, Suñer, Clara, Galvan-Casas, Cristina, Carrera, Caty, Ouchi, Dan, Prat, Núria, Ara, Jordi, Nadal, Nuria, Riel, Ricard, Funollet, Blanca, Ojeda-Ciurana, Carmen, Balague, Lluis Esteve, Salvador-González, Betlem, Arcarons, Anna Forcada, Vidal-Alaball, Josep, Del Cura-González, María Isabel, Barrientos, Ricardo Rodríguez, Ramos-Blanes, Rafel, Bou, Alberto Alum, Mondou, Elsa, Torres, Mireia, Campins, Neus, Sanz, Ana, Tang, Yonggiang, Rodriguez-Arias, Miquel Àngel, Bassat, Quique, Clotet, Bonaventura, and Mitjà, Oriol
Published: 2023
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6. Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study

Author: Tarín-Vicente, Eloy José, Alemany, Andrea, Agud-Dios, Manuel, Ubals, Maria, Suñer, Clara, Antón, Andrés, Arando, Maider, Arroyo-Andrés, Jorge, Calderón-Lozano, Lorena, Casañ, Cristina, Cabrera, José Miguel, Coll, Pep, Descalzo, Vicente, Folgueira, María Dolores, García-Pérez, Jorge N, Gil-Cruz, Elena, González-Rodríguez, Borja, Gutiérrez-Collar, Christian, Hernández-Rodríguez, Águeda, López-Roa, Paula, de los Ángeles Meléndez, María, Montero-Menárguez, Julia, Muñoz-Gallego, Irene, Palencia-Pérez, Sara Isabel, Paredes, Roger, Pérez-Rivilla, Alfredo, Piñana, María, Prat, Nuria, Ramirez, Aída, Rivero, Ángel, Rubio-Muñiz, Carmen Alejandra, Vall, Martí, Acosta-Velásquez, Kevin Stephen, Wang, An, Galván-Casas, Cristina, Marks, Michael, Ortiz-Romero, Pablo L, and Mitjà, Oriol
Published: 2022
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7. High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial

Author: Ferrer, Susana, Gallardo, Mireia, Ubals, Maria, González-Beiras, Camila, Vall-Mayans, Martí, Suñer, Clara, Laporte-Villar, Clàudia, Nieto, Aroa, Comas-Leon, Xavier, Jiménez, Zahida, Ramírez-Viaplana, Ferran, Delgado-Capel, Maria, Díez Sánchez, Beatriz, Pons Barber, Maria, Gonzalez Ruiz, Cristian, Navarrete Gonzalez, Laura, González García, David, Vivero Larraza, Ainhoa, Carceles Peiró, Victor, Roquer López, Clàudia, Robert, Neus, Palet, Carles, Gudiol, Carlota, Casares Gonzalez, Pablo, Arcos Vila, Gemma, Flores Aguilera, Begoña, Rodríguez-Sevilla, Graciela, Dastis Arias, Macarena, Roca Font, Judit, Carrasco Matos, Katherine M., Saüch Valmaña, Glòria, Vidal Obradors, Carla, Tarres García, Silvia, Curriu Sabatès, Margarida, Nieto Rodríguez, Raquel, Línio, Rosa, Fornos, Míriam, Casamitjana, Natàlia, Alonso, Eva, Martínez, Núria, Maglio, Laura Analía, Comellas Fernandez, Laura, Garcia, Nadia, Hernández, Luis, González, Maria Isabel, Bravo, Anna, García, Yolanda, Sauleda Oliveras, Silvia, Vertiz, Tatiana, Benavent, Sergio, Bianco, Andrea Sofia, Verdaguer, Joaquim, Briones Zambrano, Ney Nicanor, Viozquez Meya, Maria, Hernández, Águeda, Casaña Lopez, Cristina, Bordoy, Antoni E., González Soler, Victoria, Giménez, Montserrat, París, Alexa, Marfil, Silvia, Trinité, Benjamin, Grau, Eulàlia, Alemany, Andrea, Millat-Martinez, Pere, Corbacho-Monné, Marc, Malchair, Pierre, Ouchi, Dan, Ruiz-Comellas, Anna, Ramírez-Morros, Anna, Rodríguez Codina, Joana, Amado Simon, Rosa, Videla, Sebastian, Costes, Gèlia, Capdevila-Jáuregui, Mar, Torrano-Soler, Pamela, San José, Alba, Bonet Papell, Glòria, Puig, Jordi, Otero, Aurema, Ruibal Suarez, Jose Carlos, Zarauza Pellejero, Alvaro, Llopis Roca, Ferran, Rodriguez Cortez, Orlando, Garcia Garcia, Vanesa, Vidal-Alaball, Josep, Millan, Anna, Contreras, Enric, Grifols, Joan-Ramon, Ancochea, Àgueda, Galvan-Femenia, Ivan, Piccolo Ferreira, Francini, Bonet, Mireia, Cantoni, Jordi, Prat, Núria, Ara, Jordi, Forcada Arcarons, Anna, Farré, Magí, Pradenas, Edwards, Blanco, Julià, Àngel Rodriguez-Arias, Miquel, Fernández Rivas, Gema, Marks, Michael, Bassat, Quique, Blanco, Ignacio, Baro, Bàrbara, Clotet, Bonaventura, and Mitjà, Oriol
Published: 2022
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8. Transmission of COVID-19 in 282 clusters in Catalonia, Spain: a cohort study

Author: Marks, Michael, Millat-Martinez, Pere, Ouchi, Dan, Roberts, Chrissy h, Alemany, Andrea, Corbacho-Monné, Marc, Ubals, Maria, Tobias, Aurelio, Tebé, Cristian, Ballana, Ester, Bassat, Quique, Baro, Bàrbara, Vall-Mayans, Martí, G-Beiras, Camila, Prat, Nuria, Ara, Jordi, Clotet, Bonaventura, and Mitjà, Oriol
Published: 2021
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9. Referral of Patients to Dermatology and Teledermatology Consultations in Spain. DIADERM Study

Author: Buendía, Agustín, Fernández-Crehuet, Pablo, Husein-ElAhmed, Husein, Vega, Jesús, Viera, Agustín, Manuel Carrascosa, José, Ferrán, Marta, Gómez, Enrique, Ascanio, Lucia, García Doval, Ignacio, Arias, Salvador, Gilaberte, Yolanda, Sánchez, Juan A., Serrano, Amalia, Castillo, Rosa, Fernandez, Ramón, Armario, José, Lluc Cantalejo, Carolina, Albarrán, Cristina, Cruz Martín, María, Martín, Juan Antonio, Barabash, Román, Pérez, Lara, Salamanca, Manuel, Hernández, Carlos, Millán, José Francisco, Ruiz, Inmaculada, Armesto, Susana, González, Marta, Beteta, Valia, Cuadrado de Valles, Concepción, Cristóbal, Pilar, Roth, María Magdalena, Garcias, Juan, Fernandez de Misa, Ricardo, García, Estela, Rivero, María del Pino, Suárez, José, Farthmann, Birgit, Álvarez, Alba, García, Irene, Morales, Caridad Elena, Zemba, María Cristina, Repiso, Trinidad, Sastre, Carmen, Ubals, María, Fernández, Alejandro, González, Urbà, Grimalt, Ramón, Gómez, Sara, López, Ingrid, Gemigniani, Franco Antonio, Izquierdo, María José, Alfageme, Fernando, Barrientos, Nuria, Pericet, Laura María, Vidal, Santiago, Camarero, Celia, Lázaro, Pablo, García, Cristina, de Pablo, María Pilar, Herranz, Pedro, del Olmo, Natalia, Castellanos, María, Jiménez, Natalia, Aboín, Sonsoles, Aldanondo, Isabel, Juanes, Adriana, Arranz, Dulce María, González, Olga, Casas, Luis, Vázquez, Juan José, Peña, Carmen, Cubero, José Luis, Feal, Carlos, Mayo, María Eugenia, Iglesias, Nicolás, Rojo, Rafael, Aniz, Elfidia, Kindem, Sabrina, Barrado, Nerea, Tirado, Marisa, Quecedo, Ester, Hernández, Isabel, Sahuquillo, Antonio, Bella, Rebeca, García, Ramón, Calle, Anaid, Messeguer, Francesc, Alfaro, Alberto, Casanova, Luisa, Aspe, Libe, Moreno, María Pilar, Trébol, Izaskun, Serrano, Gonzalo, Alcalde, Víctor Manuel, García, Patricia, Coscojuela, Carmen, González-López, G., Descalzo-Gallego, M.Á., Arias-Santiago, S., Molina-Leyva, A., Gilaberte, Y., Fernández-Crehuet, P., Husein-El Ahmed, H., Viera-Ramírez, A., Fernández-Peñas, P., Taberner, R., García-Doval, I., and Buendía-Eisman, A.
Published: 2019
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10. Derivación de pacientes en consulta de dermatología y de teledermatología en España. Estudio DIADERM

Author: Buendía, Agustín, Fernández-Crehuet, Pablo, Husein-ElAhmed, Husein, Vega, Jesús, Viera, Agustín, Manuel Carrascosa, José, Ferrán, Marta, Gómez, Enrique, Ascanio, Lucia, García Doval, Ignacio, Arias, Salvador, Gilaberte, Yolanda, Sánchez, Juan A., Serrano, Amalia, Castillo, Rosa, Fernandez, Ramón, Armario, José, Lluc Cantalejo, Carolina, Albarrán, Cristina, Cruz Martín, María, Martín, Juan Antonio, Barabash, Román, Pérez, Lara, Salamanca, Manuel, Hernández, Carlos, Millán, José Francisco, Ruiz, Inmaculada, Armesto, Susana, González, Marta, Beteta, Valia, Cuadrado de Valles, Concepción, Cristóbal, Pilar, Roth, María Magdalena, Garcias, Juan, Fernandez de Misa, Ricardo, García, Estela, Rivero, María del Pino, Suárez, José, Farthmann, Birgit, Álvarez, Alba, García, Irene, Morales, Caridad Elena, Zemba, María Cristina, Repiso, Trinidad, Sastre, Carmen, Ubals, María, Fernández, Alejandro, González, Urbà, Grimalt, Ramón, Gómez, Sara, López, Ingrid, Gemigniani, Franco Antonio, Izquierdo, María José, Alfageme, Fernando, Barrientos, Nuria, Pericet, Laura María, Vidal, Santiago, Camarero, Celia, Lázaro, Pablo, García, Cristina, de Pablo, María Pilar, Herranz, Pedro, del Olmo, Natalia, Castellanos, María, Jiménez, Natalia, Aboín, Sonsoles, Aldanondo, Isabel, Juanes, Adriana, Arranz, Dulce María, González, Olga, Casas, Luis, Vázquez, Juan José, Peña, Carmen, Cubero, José Luis, Feal, Carlos, Mayo, María Eugenia, Iglesias, Nicolás, Rojo, Rafael, Aniz, Elfidia, Kindem, Sabrina, Barrado, Nerea, Tirado, Marisa, Quecedo, Ester, Hernández, Isabel, Sahuquillo, Antonio, Bella, Rebeca, García, Ramón, Calle, Anaid, Messeguer, Francesc, Alfaro, Alberto, Casanova, Luisa, Aspe, Libe, Moreno, María Pilar, Trébol, Izaskun, Serrano, Gonzalo, Alcalde, Víctor Manuel, García, Patricia, Coscojuela, Carmen, González-López, G., Descalzo-Gallego, M.Á., Arias-Santiago, S., Molina-Leyva, A., Gilaberte, Y., Fernández-Crehuet, P., Husein-El Ahmed, H., Viera-Ramírez, A., Fernández-Peñas, P., Taberner, R., García-Doval, I., and Buendía-Eisman, A.
Published: 2019
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11. Early administration of tecovirimat shortens the time to mpox clearance in a model of human infection.

Author: Nguyen, Bach Tran, Marc, Aurélien, Suñer, Clara, Marks, Michael, Ubals, Maria, Hernández-Rodríguez, Águeda, Melendez, María Ángeles, Hruby, Dennis E., Russo, Andrew T., Mentré, France, Mitjà, Oriol, Grosenbach, Douglas W., and Guedj, Jérémie
Subjects: MONKEYPOX, BASIC reproduction number, REPRODUCTION, PEAK load, DRUG efficacy, VIRAL load
Abstract: Despite use of tecovirimat since the beginning of the 2022 outbreak, few data have been published on its antiviral effect in humans. We here predict tecovirimat efficacy using a unique set of data in nonhuman primates (NHPs) and humans. We analyzed tecovirimat antiviral activity on viral kinetics in NHP to characterize its concentration–effect relationship in vivo. Next, we used a pharmacological model developed in healthy volunteers to project its antiviral efficacy in humans. Finally, a viral dynamic model was applied to characterize mpox kinetics in skin lesions from 54 untreated patients, and we used this modeling framework to predict the impact of tecovirimat on viral clearance in skin lesions. At human-recommended doses, tecovirimat could inhibit viral replication from infected cells by more than 90% after 3 to 5 days of drug administration and achieved over 97% efficacy at drug steady state. With an estimated mpox within-host basic reproduction number, R0, equal to 5.6, tecovirimat could therefore shorten the time to viral clearance if given before viral peak. We predicted that initiating treatment at symptom onset, which on average occurred 2 days before viral peak, could reduce the time to viral clearance by about 6 days. Immediate postexposure prophylaxis could not only reduce time to clearance but also lower peak viral load by more than 1.0 log10 copies/mL and shorten the duration of positive viral culture by about 7 to 10 days. These findings support the early administration of tecovirimat against mpox infection, ideally starting from the infection day as a postexposure prophylaxis. Despite its use since the beginning of the 2022 mpox outbreak, few data have been published on the antiviral effect of tecovirimat in humans. This study predicts the impact of early tecovirimat administration on the time to viral clearance in patients with mpox infection, using an integrative modeling approach that combines pre-clinical and clinical data. [ABSTRACT FROM AUTHOR]
Published: 2023
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12. Viral dynamics in patients with monkeypox infection: a prospective cohort study in Spain

Author: Suñer, Clara, primary, Ubals, Maria, additional, Tarín-Vicente, Eloy José, additional, Mendoza, Adrià, additional, Alemany, Andrea, additional, Hernández-Rodríguez, Águeda, additional, Casañ, Cristina, additional, Descalzo, Vicente, additional, Ouchi, Dan, additional, Marc, Aurélien, additional, Rivero, Àngel, additional, Coll, Pep, additional, Oller, Xènia, additional, Miguel Cabrera, José, additional, Vall-Mayans, Martí, additional, Dolores Folgueira, María, additional, Ángeles Melendez, María, additional, Agud-Dios, Manuel, additional, Gil-Cruz, Elena, additional, Paris de Leon, Alexia, additional, Ramírez Marinero, Aída, additional, Buhiichyk, Vira, additional, Galván-Casas, Cristina, additional, Paredes, Roger, additional, Prat, Nuria, additional, Sala Farre, Maria-Rosa, additional, Bonet-Simó, Josep Maria, additional, Farré, Magí, additional, Ortiz-Romero, Pablo L, additional, Clotet, Bonaventura, additional, García-Patos, Vicente, additional, Casabona, Jordi, additional, Guedj, Jeremie, additional, Cardona, Pere-Joan, additional, Blanco, Ignacio, additional, Marks, Michael, additional, Mitjà, Oriol, additional, Ramón Santos, José, additional, Bailón, Lucía, additional, Benet, Susana, additional, Arroyo Andres, Jorge, additional, Calderón Lozano, Lorena, additional, Carrasco Díaz, María, additional, Budria Serrano, Carla, additional, Crespillo Galán, Enola, additional, Parra Manzano, Ana Isabel, additional, Nef Rabadán, Pamela, additional, Muntané, Laura, additional, Sánchez-Lafuente Doncel, Cristina, additional, Marrero Pueo, Yesinei Marina, additional, Muñoz Quinto, Aroa, additional, Acosta, Marlon, additional, Alvarez, Patricia, additional, Arando, Maider, additional, García, Jorge N, additional, Monforte, Arnau, additional, Maltas Hidalgo, Yolanda, additional, Hervas Perez, Ramona, additional, and Clotet Romero, Laura, additional
Published: 2023
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13. Mpox in people with advanced HIV infection: a global case series

Author: Mitjà, Oriol, primary, Alemany, Andrea, additional, Marks, Michael, additional, Lezama Mora, Jezer I, additional, Rodríguez-Aldama, Juan Carlos, additional, Torres Silva, Mayara Secco, additional, Corral Herrera, Ever Arturo, additional, Crabtree-Ramirez, Brenda, additional, Blanco, José Luis, additional, Girometti, Nicolo, additional, Mazzotta, Valentina, additional, Hazra, Aniruddha, additional, Silva, Macarena, additional, Montenegro-Idrogo, Juan José, additional, Gebo, Kelly, additional, Ghosn, Jade, additional, Peña Vázquez, María Fernanda, additional, Matos Prado, Eduardo, additional, Unigwe, Uche, additional, Villar-García, Judit, additional, Wald-Dickler, Noah, additional, Zucker, Jason, additional, Paredes, Roger, additional, Calmy, Alexandra, additional, Waters, Laura, additional, Galvan-Casas, Cristina, additional, Walmsley, Sharon, additional, Orkin, Chloe M, additional, Leiro, Viviana, additional, Marchetta, Lucila, additional, Fernandez Pardal, Patricia, additional, Figueroa, María Inés, additional, Cahn, Pedro, additional, Grabmeier-Pfistershammer, Katharina, additional, Libois, Agnes, additional, Liesenborghs, Laurens, additional, Grinsztejn, Beatriz, additional, Schechter, Mauro, additional, dos Santos de Lemos, Alberto, additional, Furtado Costa, Alvaro, additional, Queiroz Rocha, Simone, additional, Valdez Madruga, José, additional, S. Tan, Darrell H., additional, Mishra, Sharmistha, additional, Shah, Shreya, additional, Jorquera, Camila, additional, Castillo, Alberto, additional, Carrión, Mauricio, additional, Cevallos, Nelson, additional, Palich, Romain, additional, Pourcher, Valerie, additional, Rubenstein, Emma, additional, Migaud, Pascal, additional, Boesecke, Christoph, additional, Hoffmann, Christian, additional, Protopapas, Konstantinos, additional, Nozza, Silvia, additional, Cattelan, Anna Maria, additional, Mussini, Cristina, additional, d'Arminio Monforte, Antonella, additional, Cruz Flores, Raúl Adrian, additional, Pérez Barragán, Edgar, additional, Rodríguez Guzmán, Alma Leticia, additional, Ogoina, Dimie, additional, Chika-Igwenyi, Nneka Marian, additional, Chizaram, Onyeaghala, additional, Valverde López, Jenny, additional, García Tello, Angelica, additional, Ubals, Maria, additional, Vall, Martí, additional, Mendoza, Adrià, additional, Suñer, Clara, additional, Clotet, Bonaventura, additional, Bechini, Jordi, additional, Lepe, Jose A, additional, Navarro-Amuedo, M. Dolores, additional, Bernadino, Jose Ignacio, additional, Català, Alba, additional, Tarín Vicente, Eloy José, additional, González Rodríguez, Borja, additional, Rodriguez-Mercader, Sergi, additional, Sánchez-Martinez, Francisca, additional, Cañas-Ruano, Esperanza, additional, Parra-Navarro, Laura, additional, Filén, Finn, additional, Tallón de Lara, Carmen, additional, Braun, Dominique, additional, Piezzi, Vanja, additional, Burkhard, Michael, additional, Kovari, Helen, additional, Mönch, Anja, additional, Dunning, Jake, additional, Simoes, Pedro, additional, Nori, Achyuta, additional, Keegan, Sarah, additional, Thornhill, John P, additional, Apea, Vanessa, additional, Noori, Teymur, additional, Jones, Joyce L., additional, Judson, Seth, additional, Gilliams, Elizabeth A., additional, Hammill, Matthew, additional, Keruly, Jeanne, additional, Henao Martínez, Andrés F., additional, Lin, Aung, additional, So, Jessica, additional, Davar, Kusha, additional, and Villareal, Diana, additional
Published: 2023
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14. Subcutaneous anti-COVID-19 hyperimmune immunoglobulin for prevention of disease in asymptomatic individuals with SARS-CoV-2 infection: a double-blind, placebo-controlled, randomised clinical trial

Author: Alemany, Andrea, primary, Millat-Martinez, Pere, additional, Corbacho-Monné, Marc, additional, Suñer, Clara, additional, Galvan-Casas, Cristina, additional, Carrera, Caty, additional, Ouchi, Dan, additional, Prat, Núria, additional, Ara, Jordi, additional, Nadal, Nuria, additional, Riel, Ricard, additional, Funollet, Blanca, additional, Ojeda-Ciurana, Carmen, additional, Balague, Lluis Esteve, additional, Salvador-González, Betlem, additional, Arcarons, Anna Forcada, additional, Vidal-Alaball, Josep, additional, Del Cura-González, María Isabel, additional, Barrientos, Ricardo Rodríguez, additional, Ramos-Blanes, Rafel, additional, Bou, Alberto Alum, additional, Mondou, Elsa, additional, Torres, Mireia, additional, Campins, Neus, additional, Sanz, Ana, additional, Tang, Yonggiang, additional, Rodriguez-Arias, Miquel Àngel, additional, Bassat, Quique, additional, Clotet, Bonaventura, additional, Mitjà, Oriol, additional, Aguilar-Uroz, Adrià, additional, Rosell-García-Ufano, Adrià, additional, Escudero Planas, Adrián, additional, Baelo, Aida, additional, Villahoz Martín, Ainhoa, additional, Moreno López, Alberto, additional, Roldan Ruiz, Alberto, additional, Santana Briongos, Alberto, additional, Tejera Bodas, Alberto, additional, Alonso-Vallés, Alejandro, additional, Fletes-Pérez, Alejandro, additional, Hueso-Mor, Alejandro, additional, Boluda, Alex, additional, Santamaria, Alex, additional, Diestro, Alicia Santos, additional, Revuelta-Álvarez, Almudena, additional, Moreno Moreno, Álvaro, additional, Ortega de Felipe, Ana, additional, Chen-Ye, Ana, additional, Blázquez Valerón, Ana, additional, Rodríguez Pérez, Ana Belén, additional, Tristán Morgalo, Ana Laura, additional, Fernández-Allende, Ana Luisa, additional, Bagán-Trejo, Andrea, additional, Fernández Juan, Andrés, additional, Zalve-Cano, Ángel, additional, Mateo-Martínez, Anna, additional, Galván, Antonio Valero, additional, Egidos-Plaja, Antonio, additional, Jorge, Ariadna, additional, Fraile Torres, Arturo, additional, Pareja Leal, Azahara Maria, additional, Viader Castro, Bárbara, additional, Fernandez Beato, Barbara, additional, Naveira Menchen, Barbara, additional, Martin Poyatos, Beatriz, additional, García-Martínez, Beatriz, additional, Rodrigo Testillano, Belén, additional, Blanco Tejedor, Belen, additional, López Pérez, Blanca, additional, Mencía Hernanz, Blanca, additional, González-Beiras, Camila, additional, Batres, Carlos, additional, Nuñez Garcia, Carmen, additional, Merino-Rodríguez, Carmen, additional, Rodríguez-Gilabert, Carolina, additional, Bonilla Penedo, Celia, additional, Casado Gomez, Christian, additional, Gonzalez Perez, Claudia, additional, Galindo-Tomás, Claudia, additional, Peral Bolaños, Cristina, additional, Blanco-Montes, Cristina, additional, Lupu-Yakovleva, Cristina, additional, Lopez Ruiz, Cristina, additional, Perez Mayoral, Cristina, additional, Fornes, Cristina, additional, Garcia Corrochano, Cristobal, additional, Gallardo Álvarez, Daniel, additional, Navarro Sanz, Daniel, additional, Sanz Barrio, David, additional, Ramet Meseguer, Debora, additional, Vera-Jurado, Edna Margarita, additional, Perez Costa, Eduardo, additional, Bustillos-Sebastian, Eilen Junet, additional, Palomar Casado, Elena, additional, Guerrero, Elena Dorrego, additional, Medina Mateos, Elena, additional, Aragón Gaspar, Elisa Rebeca, additional, Herrero-Vila, Elisabeth, additional, Paez Herrera, Enriqueta, additional, Rojas Powel, Esmeralda, additional, Robres Medialdea, Esther, additional, Vall-Ribalta, Esther, additional, Lopez Perez, Eva, additional, Mihaela Fer, Felicia, additional, Vazquez Ángeles, Fernanda, additional, Tirado Bejarano, Fernando, additional, Prats-Domenech, Ferran, additional, Borràs Martí, Ferran, additional, Ardila-Mejia, Gabriela, additional, Costes, Gèlia, additional, Gómez Arquero, Gema, additional, Flores Mateo, Gemma, additional, Pintos-Morell, Guillem, additional, Mira-Centelles, Helena, additional, Astola Requena, Ignacio, additional, Ortega Martin, Ignacio, additional, Leivas-Gutierrez, Iker, additional, Escribano Valenciano, Irene, additional, Muñoz Gomez, Irene, additional, Ortega, Irina, additional, Montserrat-Lloan, Isabel, additional, Gamboa, Itziar, additional, Rodríguez de Torres de Paul, Jacobo, additional, Cahís, Jordi, additional, Muñoz-Martinez, Jordi, additional, Bermejo, Jorge Iglesias, additional, Cejas López, Joselvis Virginia, additional, Canudas, Josep, additional, García Lucas, Juan Antonio, additional, Martínez-Pino, Juan Carlos, additional, Torres Martínez, Juana, additional, Pujol-Corney, Judit, additional, González Jiménez, Judith, additional, Gurí, Júlia, additional, Labella Martín, Julio, additional, Garcia-Cano, Laia, additional, Perez Plata, Lara Sonsoles, additional, Muñoz Álvaro, Laura, additional, Rodríguez Andrés, Laura, additional, Vega Ruiz, Laura, additional, Cuevas Valiente, Laura, additional, Díaz Rodríguez, Laura, additional, Puigros, Laura, additional, Cristina Piciorang, Lavinia, additional, Escudero, Leticia, additional, Figueroa Caballero, Liliana, additional, Ferrerfàbrega-Costals, Lluna, additional, Costafreda-Hernández, Lucía, additional, De-Paúl, Lucía, additional, González Fernández-Medina, Luis, additional, Moliner Prada, Ma Carmen, additional, Berriochoa Martínez de Pisón, Ma Cristina, additional, Blanco Blasco, Maria, additional, Gil Jorge, Maria, additional, Cortijo Caballero, María, additional, Ubals, Maria, additional, Gordillo, Maria, additional, Guilloto López, Maria Alicia, additional, Moreno Calvo, Maria Concepción, additional, Gil García, María del Rosario, additional, Dueñas Román, María Inmaculada, additional, Gonzalez Sanchez, Maria Josefa, additional, Nicolás Campoy, María Luisa, additional, González Velayos, Maria Luz, additional, Zori, Mario Mejías, additional, Maqueda, Mario Oliva, additional, Caño de la Cruz, Mario, additional, Palau-Morral, Mariona, additional, Martín-Muñoz, Marta, additional, Cereceda Meca, Marta, additional, Díaz Urbina, Marta, additional, VerónicaPlazas, Martha, additional, Vall-Mayans, Martí, additional, Blasco, Martí, additional, Jane Chu-Sifuentes, Mary, additional, García de Villasladad Peñaranda, Miguel, additional, Hernanz Sotoca, Miguel, additional, Iglesias Gonzalez, Miguel, additional, Labrador-Galván, Miguel Ángel, additional, Rodrigo de Vivar Azcarate, Miguel, additional, Gil-Fibla, Miquel, additional, Formentí-Pallarés, Miquel, additional, Esteve-Tugues, Mireia, additional, Juanes Perez, Miriam, additional, López Rubio, Miriam, additional, Recuero Renales, Mirian, additional, Hijós-Rullo, Mònica, additional, Lleonart-Abadia, Montserrat, additional, Finelli, Nadia, additional, Rojas-Bertier, Naiara, additional, Reyes-Calderón, Nataly, additional, Casado Larrañaga, Nerea, additional, Zurita Castrosin, Nerea Nuria, additional, Álvarez-Nieto, Noélia, additional, Leiva-Mora, Nuria, additional, Tomillo-Martín, Olga, additional, Belghazi, Omar, additional, Buscà, Oriol, additional, Mendoza Cediel, Pablo, additional, Macedo, Pablo, additional, Rodríguez Barroso, Patricia, additional, Ruiz Álvarez, Patricia, additional, López, Patricia Morales, additional, Vara de Rey, Patricia Jimenez, additional, Ginés, Paz Lozano, additional, Bris Rodriguez, Pilar, additional, Martínez-Alamillo, Pilar, additional, Salmerón Martínez, Rafa, additional, Botello Ariza, Raquel, additional, Vaquero Mena, Raquel, additional, González-Alonso, Raquel, additional, Kaczmarczyk, Raul, additional, Barnadas Vintró, Rita, additional, Hontecillas Martínez, Rodrigo, additional, Ribot-Rodríguez, Rosa, additional, Escobar-Sánchez, Rosa, additional, Montes Trinidad, Rosario Paloma, additional, Martínez Quintana, Rubén, additional, Arnay Arrogante, Ruben, additional, Berjon Sanchez, Ruben, additional, Picazo Navarro, Ruben, additional, Bastos, Rubén, additional, Martín Molinero, Samuel, additional, Israel-Benchaya, Samuel Dan, additional, Muñoz-Burguillo, Sandra, additional, Rodríguez-Salvador, Sandra, additional, Avila, Sara, additional, Corral Gayubas, Sara, additional, Nuñez Sánchez, Sergio, additional, Torres Weber, Sofía, additional, Encabo Lopez, Susana, additional, Torices Rasines, Teresa, additional, Sallas, Valentí, additional, Curto-Vicente, Verónica, additional, Gómez Hijosa, Verónica, additional, Daimiel-Pedrote, Verónica, additional, Gozalo, Verónica, additional, Barrios López, Vicente, additional, Castillo Montoya, Virginia Ivette, additional, Espinoza Pérez, Yuri, additional, CristinaBerriochoa Martínez de Pisón, María, additional, Muñoz Castillo, David, additional, Donato, Carlos, additional, and García García, Isabel, additional
Published: 2023
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15. Antimicrobial susceptibility of Treponema pallidum subspecies pallidum: an in-vitro study

Author: European Commission, European Research Council, University of Washington, National Institutes of Health (US), Tantalo, Lauren C., Lieberman, Nicole A. P., Pérez-Mañá, Clara, Suñer, Clara, Vall Mayans, Marti, Ubals, Maria, González-Beiras, Camila, Rodríguez-Gascón, Alicia, Canut, Andrés, González-Candelas, Fernando, Mueller, John, Tapia, Kenneth, Greninger, Alexander L., Giacani, Lorenzo, Mitjà, Oriol, European Commission, European Research Council, University of Washington, National Institutes of Health (US), Tantalo, Lauren C., Lieberman, Nicole A. P., Pérez-Mañá, Clara, Suñer, Clara, Vall Mayans, Marti, Ubals, Maria, González-Beiras, Camila, Rodríguez-Gascón, Alicia, Canut, Andrés, González-Candelas, Fernando, Mueller, John, Tapia, Kenneth, Greninger, Alexander L., Giacani, Lorenzo, and Mitjà, Oriol
Abstract: [Background]: The increasing incidence of syphilis and the limitations of first-line treatment with penicillin, particularly in neurosyphilis, neonatal syphilis, and pregnancy, highlight the need to expand the therapeutic repertoire for effective management of this disease. We assessed the in-vitro efficacy of 18 antibiotics from several classes on Treponema pallidum subspecies pallidum (T pallidum), the syphilis bacteria., [Methods]: Using the in-vitro culture system for T pallidum, we exposed the pathogen to a concentration range of each tested antibiotic. After a 7-day incubation, the treponemal burden was evaluated by quantitative PCR targeting the T pallidum tp0574 gene. The primary outcome was the minimum inhibitory concentration (MIC) at which the quantitative PCR values were not significantly higher than the inoculum wells. We also investigated the susceptibility of macrolide-resistant strains to high concentrations of azithromycin, and the possibility of developing resistance to linezolid, a proposed candidate for syphilis treatment., [Findings]: Amoxicillin, ceftriaxone, several oral cephalosporins, tedizolid, and dalbavancin exhibited anti-treponemal activity at concentrations achievable in human plasma following regular dosing regimens. The experiments revealed a MIC for amoxicillin at 0·02 mg/L, ceftriaxone at 0·0025 mg/L, cephalexin at 0·25 mg/L, cefetamet and cefixime at 0·0313 mg/L, cefuroxime at 0·0156 mg/L, tedizolid at 0·0625 mg/L, spectinomycin at 0·1 mg/L, and dalbavancin at 0·125 mg/L. The MIC for zoliflodacin and balofloxacin was 2 mg/L. Ertapenem, isoniazid, pyrazinamide, and metronidazole had either a poor or no effect. Azithromycin concentrations up to 2 mg/L (64 times the MIC) were ineffective against strains carrying mutations associated to macrolide resistance. Exposure to subtherapeutic doses of linezolid for 10 weeks did not induce phenotypic or genotypic resistance., [Interpretation]: Cephalosporins and oxazolidinones are potential candidates for expanding the current therapeutic repertoire for syphilis. Our findings warrant testing efficacy in animal models and, if successful, clinical assessment of efficacy.
Published: 2023

16. Evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox

Author: Ubals, Maria, primary, Tarín-Vicente, Eloy José, additional, Oller, Xènia, additional, Mendoza, Adrià, additional, Alemany, Andrea, additional, Hernández-Rodríguez, Águeda, additional, Casañ, Cristina, additional, Rivero, Ángel, additional, Coll, Pep, additional, Cabrera, José Miguel, additional, Vall, Martí, additional, Agud-Dios, Manuel, additional, Gil-Cruz, Elena, additional, de Leon, Alexia Paris, additional, Ramírez, Aída, additional, Folgueira, María Dolores, additional, Melendez, María Angeles, additional, Buhiichyk, Vira, additional, Galván-Casas, Cristina, additional, Paredes, Roger, additional, Prat, Nuria, additional, Farre, Maria-Rosa Sala, additional, Bonet-Simó, Josep Maria, additional, Ortiz-Romero, Pablo L, additional, Clotet, Bonaventura, additional, Cardona, Pere-Joan, additional, Blanco, Ignacio, additional, Marks, Michael, additional, Suñer, Clara, additional, and Mitjà, Oriol, additional
Published: 2022
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17. Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Author: Rokx, Casper, Lammers, Jolanda, Buitenhuis, Lonneke, Postma, Douwe, Koster, David, Lukens, Michaèl, Scholtens, Thea, Boomgaard, Maartje van den, Kampschreur, Linda, Ubals, Maria, Prat, Núria, Díez Sánchez, Beatriz, Vértiz Guidotti, Thatiana, Pons Barber, Maria, Gonzalez Ruiz, Cristian, Navarrete Gonzalez, Laura, Ancochea, Àgueda, Ferrer, Magí, Videla, Sebas, Gudiol, Carlota, Fernández Rivas, Gema, CoV-Early Study Group, Vonderen, Marit van, Bianco, Andrea Sofia, Bravo, Anna, Otero, Aurema, Ruibal Suarez, Jose Carlos, Benavent, Sergio, Zarauza Pellejero, Alvaro, Línio, Rosa, Malchair, Pierre, Llopis Roca, Ferran, Blanco, Julian, Rodriguez Cortez, Orlando, Casares Gonzalez, Pablo, Arcos Vila, Gemma, García, Yolanda, Roca Font, Judit, Carrasco Matos, Katherine M., Saüch Valmaña, Glòria, Vidal Obradors, Carla, Koopmans, Marion, Ara, Jordi, COnV-ert Study Group, Rodríguez Codina, Joana, Tarres García, Silvia, Blanco, Ignacio, Hernández, Águeda, González Soler, Victoria, Curriu Sabatès, Margarida, Nieto Rodríguez, Raquel, Grífols, Joan Ramon, Briones Zambrano, Ney Nicanor, Millan, Anna, Capdevila Jáuregui, Mar, Fornos, Miriam, Casamitjana, Natàlia, Bordoy, Antoni E., Alonso, Eva, Zwet, Erik van, Miedema, Jelle, Martinez, Núria, Ramírez Morros, Anna, Bogers, Susanne, Maglio, Laura Analía, Amado Simon, Rosa, Comellas Fernandez, Laura, Garcia, Nadia, Ruiz Comellas, Anna, Baro, Bàrbara, Hernández, Luis, Viozquez Meya, Maria, Costes, Gèlia, Pradenas, Edwars, Forcada, Anna, Ginneken, Betty van, Harvala, Heli, Marfil, Silvia, Troxel, Andrea, Mooijaart, Simon, Trinité, Benjamin, Piccolo Ferreira, Francini, Bonet, Mireia, Cantoni, Jordi, Russcher, Henk, Marks, Michael, Zwaginga, Jaap Jan, Torrano Soler, Pamela, Mitjà, Oriol, Rijnders, Bart J. A., Droog, José de, Corbacho Monné, Marc, Scherpenisse, Cees, Hollander, Jan den, Gharbharan, Arvind, Jordans, Carlijn, Geurtsvankessel, Corine, Albersen, Arjan, Papageourgiou, Grigorios, Katsikis, Peter, Vall Mayans, Martí, Müller, Yvonne, Reusken, Chantal, San José, Alba, Ferrer, Susana, Engen, Rene van, Karisli, Ayten, Götz, Hannelore, Struik, Jelle, París, Alexa, Suñer Navarro, Clara, Clotet, Bonaventura, 1953, Reimerink, Johan, Rokx-Niemantsverdriet, Lotte, Rodriguez Arias, Miquel Angel, Jiménez, Zahida, Verstijnen, Jose, Geloven, Nan van, Groeneveld, Geert, Zwaginga, Lisa, Oud, Josine, Meier, Romy, González Beiras, Camila, Swaneveld, Francis, Ramírez Viaplana, Ferran, Schoot, Ellen van der, Vrielink, Hans, Flores Aguilera, Begoña, Vivero Larraza, Ainhoa, Watering, Leo van de, Hogema, Boris, González García, David, Wijngaarden, Peter van, Vidal Alaball, Josep, Etten, Ronald van, Gammeren, Adriaan van, Alemany, Andrea, Puig, Jordi, Maas, Nanda, Berg – Rahman, Juliette van der, Karim, Faiz, Hiddema, Siepke, Elst, Kim van, García García, Vanesa, Casañ Lopez, Cristina, Leeuwen-Segarceanu, Elena van, Nieto, Aroa, Rodríguez Sevilla, Graciela, Reitsma, Annette, Molenkamp, Karin, Soetekouw, Robert, Band, Caterina, Carceles Peiró, Victor, Gallardo, Mireia, Galvan Femenia, Ivan, Comas Leon, Xavier, Millat Martínez, Pere, Bassat Orellana, Quique, González, María Isabel, Verdaguer, Joaquim, Roquer López, Clàudia, Contreras, Enric, Giménez, Montserrat, Ouchi, Dan, Blanco Guillermo, Ignacio, Bonet Papell, Glòria, Dastis Arias, Macarena, Delgado Capel, Maria, Faculteit Medische Wetenschappen/UMCG, Internal Medicine, Medical Microbiology & Infectious Diseases, Virology, and Epidemiology
Subjects: Immunoregulació, Multidisciplinary, SARS-CoV-2, Immunization, Passive, Immunoregulation, COVID-19, General Physics and Astronomy, Bayes Theorem, General Chemistry, Middle Aged, General Biochemistry, Genetics and Molecular Biology, Treatment Outcome, Outpatients, Humans, Multicenter Studies as Topic, COVID-19 Serotherapy, Randomized Controlled Trials as Topic
Abstract: Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitalization of outpatients. Two multicenter, double-blind randomized trials (NCT04621123, NCT04589949) were merged with data pooling starting when Trial registration: Clinicaltrials.gov NCT04621123 and NCT04589949. Registration: NCT04621123 and NCT04589949 on https://www.clinicaltrials.gov
Published: 2022

18. Evaluating the Accuracy of Self-Collected Swabs for the Diagnosis of Mpox.

Author: Ubals, Maria, Tarín-Vicente, Eloy José, Oller, Xènia, Mendoza, Adrià, Alemany, Andrea, Hernández-Rodríguez, Águeda, Casañ, Cristina, Rivero, Ángel, Coll, Pep, Cabrera, José Miguel, Vall, Martí, Agud-Dios, Manuel, Gil-Cruz, Elena, Leon, Alexia Paris de, Marinero, Aída Ramírez, Folgueira, María Dolores, Meléndez, María Ángeles, Buhiichyk, Vira, Galván-Casas, Cristina, and Paredes, Roger
Subjects: *SKIN, *MONKEYPOX, *PATIENTS, *RECTUM, *COLLECTION & preservation of biological specimens, *PHYSICIANS, *POLYMERASE chain reaction, *OROPHARYNX, *LONGITUDINAL method
Abstract: We evaluated the accuracy of patient-collected skin lesions, oropharyngeal, and rectal swabs among 50 individuals enrolled in a study of mpox viral dynamics. We found that the performance of self-collected samples was similar to that of physician-collected samples, suggesting that self-sampling is a reliable strategy for diagnosing mpox. [ABSTRACT FROM AUTHOR]
Published: 2023
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19. Virological and Clinical Determinants of the Magnitude of Humoral Responses to SARS-CoV-2 in Mild-Symptomatic Individuals

Author: Pradenas, Edwards, primary, Ubals, Maria, additional, Urrea, Víctor, additional, Suñer, Clara, additional, Trinité, Benjamin, additional, Riveira-Muñoz, Eva, additional, Marfil, Silvia, additional, Ávila-Nieto, Carlos, additional, Rodríguez de la Concepción, María Luisa, additional, Tarrés-Freixas, Ferran, additional, Laporte, Josep, additional, Ballana, Ester, additional, Carrillo, Jorge, additional, Clotet, Bonaventura, additional, Mitjà, Oriol, additional, and Blanco, Julià, additional
Published: 2022
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20. Yaws recurrence in children at continued risk of infection

Author: Beiras, Camila G., primary, Marks, Michael, additional, Quintó, Llorenç, additional, Gavilán, Sergi, additional, Kolmau, Reman, additional, Ubals, Maria, additional, Vall-Mayans, Marti, additional, and Mitjà, Oriol, additional
Published: 2022
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21. High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial

Author: Alemany, Andrea, primary, Millat-Martinez, Pere, additional, Corbacho-Monné, Marc, additional, Malchair, Pierre, additional, Ouchi, Dan, additional, Ruiz-Comellas, Anna, additional, Ramírez-Morros, Anna, additional, Rodríguez Codina, Joana, additional, Amado Simon, Rosa, additional, Videla, Sebastian, additional, Costes, Gèlia, additional, Capdevila-Jáuregui, Mar, additional, Torrano-Soler, Pamela, additional, San José, Alba, additional, Bonet Papell, Glòria, additional, Puig, Jordi, additional, Otero, Aurema, additional, Ruibal Suarez, Jose Carlos, additional, Zarauza Pellejero, Alvaro, additional, Llopis Roca, Ferran, additional, Rodriguez Cortez, Orlando, additional, Garcia Garcia, Vanesa, additional, Vidal-Alaball, Josep, additional, Millan, Anna, additional, Contreras, Enric, additional, Grifols, Joan-Ramon, additional, Ancochea, Àgueda, additional, Galvan-Femenia, Ivan, additional, Piccolo Ferreira, Francini, additional, Bonet, Mireia, additional, Cantoni, Jordi, additional, Prat, Núria, additional, Ara, Jordi, additional, Forcada Arcarons, Anna, additional, Farré, Magí, additional, Pradenas, Edwards, additional, Blanco, Julià, additional, Àngel Rodriguez-Arias, Miquel, additional, Fernández Rivas, Gema, additional, Marks, Michael, additional, Bassat, Quique, additional, Blanco, Ignacio, additional, Baro, Bàrbara, additional, Clotet, Bonaventura, additional, Mitjà, Oriol, additional, Ferrer, Susana, additional, Gallardo, Mireia, additional, Ubals, Maria, additional, González-Beiras, Camila, additional, Vall-Mayans, Martí, additional, Suñer, Clara, additional, Laporte-Villar, Clàudia, additional, Nieto, Aroa, additional, Comas-Leon, Xavier, additional, Jiménez, Zahida, additional, Ramírez-Viaplana, Ferran, additional, Delgado-Capel, Maria, additional, Díez Sánchez, Beatriz, additional, Pons Barber, Maria, additional, Gonzalez Ruiz, Cristian, additional, Navarrete Gonzalez, Laura, additional, González García, David, additional, Vivero Larraza, Ainhoa, additional, Carceles Peiró, Victor, additional, Roquer López, Clàudia, additional, Robert, Neus, additional, Palet, Carles, additional, Gudiol, Carlota, additional, Casares Gonzalez, Pablo, additional, Arcos Vila, Gemma, additional, Flores Aguilera, Begoña, additional, Rodríguez-Sevilla, Graciela, additional, Dastis Arias, Macarena, additional, Roca Font, Judit, additional, Carrasco Matos, Katherine M., additional, Saüch Valmaña, Glòria, additional, Vidal Obradors, Carla, additional, Tarres García, Silvia, additional, Curriu Sabatès, Margarida, additional, Nieto Rodríguez, Raquel, additional, Línio, Rosa, additional, Fornos, Míriam, additional, Casamitjana, Natàlia, additional, Alonso, Eva, additional, Martínez, Núria, additional, Maglio, Laura Analía, additional, Comellas Fernandez, Laura, additional, Garcia, Nadia, additional, Hernández, Luis, additional, González, Maria Isabel, additional, Bravo, Anna, additional, García, Yolanda, additional, Sauleda Oliveras, Silvia, additional, Vertiz, Tatiana, additional, Benavent, Sergio, additional, Bianco, Andrea Sofia, additional, Verdaguer, Joaquim, additional, Briones Zambrano, Ney Nicanor, additional, Viozquez Meya, Maria, additional, Hernández, Águeda, additional, Casaña Lopez, Cristina, additional, Bordoy, Antoni E., additional, González Soler, Victoria, additional, Giménez, Montserrat, additional, París, Alexa, additional, Marfil, Silvia, additional, Trinité, Benjamin, additional, and Grau, Eulàlia, additional
Published: 2022
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22. Rapid Serologic Test for Diagnosis of Yaws in Patients with Suspicious Skin Ulcers.

Author: Suñer, Clara, John, Lucy N., Houinei, Wendy, Ubals, Maria, Ouchi, Dan, Alemany, Andrea, Galván-Casas, Cristina, Marks, Michael, Mitjà, Oriol, Vall-Mayans, Martí, and Beiras, Camila G.
Subjects: SKIN ulcers, SYPHILIS, TREPONEMA pallidum, DIAGNOSTIC use of polymerase chain reaction, MEDICAL screening, ULCERS
Abstract: The Chembio DPP (Dual Path Platform) Syphilis Screen & Confirm kit (https://chembio.com) is a rapid serologic test that can be used to diagnose yaws. We evaluated its capacity to detect patients with ulcers that tested PCR positive for Treponema pallidum subsp. pertenue. DPP detected 84% of ulcers that were positive by PCR. [ABSTRACT FROM AUTHOR]
Published: 2023
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23. Viral Dynamics in Patients with Monkeypox Infection: A Prospective Cohort Study in Spain

Author: Suñer, Clara, primary, Ubals, Maria, additional, Tarín-Vicente, Eloy José, additional, Mendoza, Adrià, additional, Alemany, Andrea, additional, Hernández-Rodríguez, Águeda, additional, Casañ, Cristina, additional, Descalzo, Vicente, additional, Ouchi, Dan, additional, Marc, Aurelien, additional, Rivero, Ángel, additional, Coll, Pep, additional, Oller, Xènia, additional, Cabrera, José Miguel, additional, Vall-Mayans, Martí, additional, Dolores Folgueira, María, additional, Meléndez, María de los Ángeles, additional, Agud-Dios, Manuel, additional, Gil-Cruz, Elena, additional, de León, Alexia Paris, additional, Ramirez, Aída, additional, Buhiichyk, Vira, additional, Galván-Casas, Cristina, additional, Paredes, Roger, additional, Prat, Nuria, additional, Sala Farre, Maria-Rosa, additional, Bonet-Simó, Josep Maria, additional, Farré, Magí, additional, Ortiz-Romero, Pablo L., additional, Clotet, Bonaventura, additional, Guedj, Jeremie, additional, Cardona, Pere-Joan, additional, Blanco, Ignacio, additional, Marks, Michael, additional, Mitja, Oriol, additional, and Group, The Movie Group, additional
Published: 2022
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24. In Vitro Antimicrobial Susceptibility of Treponema Pallidum Subsp. Pallidum, the Syphilis Agent

Author: Tantalo, Lauren, primary, Lieberman, Nicole A. P., additional, Pérez-Mañá, Clara, additional, Vall Mayans, Marti, additional, Ubals, Maria, additional, González-Beiras, Camila, additional, Rodríguez-Gascón, Alicia, additional, Canut, Andrés, additional, Greninger, Alex, additional, Giacani, Lorenzo, additional, and Mitja, Oriol, additional
Published: 2022
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25. Clinical Presentation and Virological Assessment of Confirmed Human Monkeypox Virus Cases in Spain : A Prospective Cohort Study

Author: Tarín-Vicente, Eloy José, primary, Agud-Dios, Manuel, additional, Alemany, Andrea, additional, Ubals, Maria, additional, Suñer, Clara, additional, Antón, Andrés, additional, Arando, Maider, additional, Arroyo-Andrés, Jorge, additional, Calderón-Lozano, Lorena, additional, Casañ, Cristina, additional, Cabrera, José Miguel, additional, Coll, Pep, additional, Descalzo, Vicente, additional, Dolores Folgueira, María, additional, García-Pérez, Jorge N., additional, Gil-Cruz, Elena, additional, González-Rodríguez, Borja, additional, Gutiérrez-Collar, Christian, additional, Hernández-Rodríguez, Águeda, additional, López-Roa, Paula, additional, Meléndez, María de los Ángeles, additional, Montero-Menárguez, Julia, additional, Muñoz-Gallego, Irene, additional, Palencia-Pérez, Sara Isabel, additional, Paredes, Roger, additional, Pérez-Revilla, Alfredo, additional, Piñana, María, additional, Prat, Nuria, additional, Ramirez, Aída, additional, Rivero, Ángel, additional, Rubio-Muñiz, Carmen Alejandra, additional, Vall-Mayans, Martí, additional, Acosta-Velásquez, Kevin Stephen, additional, Wang, An, additional, Galván-Casas, Cristina, additional, Marks, Michael, additional, Ortiz-Romero, Pablo L., additional, and Mitja, Oriol, additional
Published: 2022
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26. Changes in the microbiological diagnosis and epidemiology of cutaneous leishmaniasis in real-time PCR era: A six-year experience in a referral center in Barcelona

Author: Silgado, Aroa, primary, Armas, Mayuli, additional, Sánchez-Montalvá, Adrián, additional, Goterris, Lidia, additional, Ubals, Maria, additional, Temprana-Salvador, Jordi, additional, Aparicio, Gloria, additional, Chicharro, Carmen, additional, Serre-Delcor, Núria, additional, Ferrer, Berta, additional, Molina, Israel, additional, García-Patos, Vicenç, additional, Pumarola, Tomas, additional, and Sulleiro, Elena, additional
Published: 2021
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27. Utility of Ultrasound in a Rapidly Growing Cutaneous Nodule in an Infant

Author: Ubals, Maria, Castany, Anna, Bassas, Patricia, Mollet, Jordi, Aparicio, Gloria, and García-Patos, Vicente
Published: 2017
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28. Analytical and clinical performance of the panbio COVID-19 antigen-detecting rapid diagnostic test

Author: Alemany, Andrea, Baró, Bàrbara, Ouchi, Dan, Rodó, Pau, Ubals, Maria, Corbacho-Monné, Marc, Vergara-Alert, Júlia, Rodon, Jordi, Segalés, Joaquim, Esteban, Cristina, Fernández, Gema, Ruiz, Lidia, Bassat, Quique, Clotet, Bonaventura, Ara, Jordi, Vall-Mayans, Martí, G-Beiras, Camila, Blanco, Ignacio, and Mitjà, Oriol
Published: 2021
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29. Treatment of Complex Cutaneous Leishmaniasis with Liposomal Amphotericin B

Author: Ubals, Maria, primary, Bosch-Nicolau, Pau, additional, Sánchez-Montalvá, Adrián, additional, Salvador, Fernando, additional, Aparicio-Español, Gloria, additional, Sulleiro, Elena, additional, Silgado, Aroa, additional, Soriano-Arandes, Antoni, additional, Espiau, Maria, additional, Ferrer, Berta, additional, Pou, Diana, additional, Treviño, Begoña, additional, Molina, Israel, additional, and García-Patos, Vicente, additional
Published: 2021
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30. Performance characteristics of five antigen-detecting rapid diagnostic test (Ag-RDT) for SARS-CoV-2 asymptomatic infection: a head-to-head benchmark comparison

Author: Baro, Bàrbara, primary, Rodo, Pau, additional, Ouchi, Dan, additional, Bordoy, Antoni E., additional, Saya Amaro, Emilio N., additional, Salsench, Sergi V., additional, Molinos, Sònia, additional, Alemany, Andrea, additional, Ubals, Maria, additional, Corbacho-Monné, Marc, additional, Millat-Martinez, Pere, additional, Marks, Michael, additional, Clotet, Bonaventura, additional, Prat, Nuria, additional, Estrada, Oriol, additional, Vilar, Marc, additional, Ara, Jordi, additional, Vall-Mayans, Martí, additional, G-Beiras, Camila, additional, Bassat, Quique, additional, Blanco, Ignacio, additional, and Mitjà, Oriol, additional
Published: 2021
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31. Efficacy of linezolid on Treponema pallidum, the syphilis agent : A preclinical study

Author: Haynes, Austin M., Giacani, Lorenzo, Mayans, Marti Vall, Ubals, Maria, Nieto, Carles, Pérez-Mañá, Clara, Quintó, Llorenç, Romeis, Emily, Mitjà, Oriol, Haynes, Austin M., Giacani, Lorenzo, Mayans, Marti Vall, Ubals, Maria, Nieto, Carles, Pérez-Mañá, Clara, Quintó, Llorenç, Romeis, Emily, and Mitjà, Oriol
Abstract: Penicillin G, the current standard treatment for syphilis, has important drawbacks, but virtually no preclinical or clinical studies have been performed to identify viable alternatives. We tested, both in vitro and in vivo, three marketed antibiotics with adequate pharmacological properties to treat syphilis. We used an in vitro culturing system of T. pallidum to perform drug susceptibility testing and applied quantitative PCR targeting the tp0574 gene to measure bacterial growth. To confirm in vivo efficacy, fifteen rabbits were infected intradermally with T. pallidum at eight sites each and randomly allocated to an experimental treatment (linezolid, moxifloxacin, clofazimine) or a control arm (benzathine penicillin G [BPG], untreated). The primary outcome was treatment efficacy defined as the time to lesion healing measured from the date of treatment start. Secondary outcomes were absence of treponemes or treponemal mRNA in injection sites, absence of seroconversion, and cerebrospinal fluid (CSF) abnormalities and negative rabbit infectivity tests (RIT). Linezolid showed in vitro bactericidal activity at concentrations of 0.5 µg/mL or higher. When administered orally to experimentally infected rabbits, it induced healing of early lesions at a time similar to BPG (hazard ratio 3.84; 95% CI 2.05-7.17; p < 0.0001 compared to untreated controls). In linezolid-treated animals, dark-field microscopy and qPCR assessment showed no presence of treponemes after day 3 post-treatment start, serologic test did not convert to positive, CSF had no abnormalities, and RIT was negative. Moxifloxacin and clofazimine failed to inhibit bacterial growth in vitro and could not cure the infection in the rabbit model. Linezolid, a low-cost oxazolidinone, has in vitro and in vivo activity against T. pallidum, with efficacy similar to BPG in treating treponemal lesions in the animal model. Our findings warrant further research to assess the efficacy of linezolid as an alternative to penicil
Published: 2021

32. Hydroxychloroquine for Early Treatment of Adults With Mild Coronavirus Disease 2019: A Randomized, Controlled Trial

Author: 0000-0002-8132-5645, Mitjà, Oriol, Corbacho-Monné, Marc, Ubals, Maria, Tebé, Cristian, Peñafiel, Judith, Tobías, Aurelio, Ballana, Ester, Alemany, Andrea, Riera-Martí, Núria, Pérez, Carla A, Suñer, Clara, Laporte, Pep, Admella, Pol, Mitjà, Jordi, Clua, Mireia, Bertran, Laia, Sarquella, Maria, Gavilán, Sergi, Ara, Jordi, Argimon, Josep M, Casabona, Jordi, Cuatrecasas, Gabriel, Cañadas, Paz, Elizalde-Torrent, Aleix, Fabregat, Robert, Farré, Magí, Forcada, Anna, Flores-Mateo, Gemma, Muntada, Esteve, Nadal, Núria, Narejos, Silvia, Nieto, Aroa, Prat, Nuria, Puig, Jordi, Quiñones, Carles, Reyes-Ureña, Juliana, Ramírez-Viaplana, Ferran, Ruiz, Lidia, Riveira-Muñoz, Eva, Sierra, Alba, Velasco, César, Vivanco-Hidalgo, Rosa M., Sentís, Alexis, G-Beiras, Camila, Clotet, Bonaventura, Vall-Mayans, Martí, 0000-0002-8132-5645, Mitjà, Oriol, Corbacho-Monné, Marc, Ubals, Maria, Tebé, Cristian, Peñafiel, Judith, Tobías, Aurelio, Ballana, Ester, Alemany, Andrea, Riera-Martí, Núria, Pérez, Carla A, Suñer, Clara, Laporte, Pep, Admella, Pol, Mitjà, Jordi, Clua, Mireia, Bertran, Laia, Sarquella, Maria, Gavilán, Sergi, Ara, Jordi, Argimon, Josep M, Casabona, Jordi, Cuatrecasas, Gabriel, Cañadas, Paz, Elizalde-Torrent, Aleix, Fabregat, Robert, Farré, Magí, Forcada, Anna, Flores-Mateo, Gemma, Muntada, Esteve, Nadal, Núria, Narejos, Silvia, Nieto, Aroa, Prat, Nuria, Puig, Jordi, Quiñones, Carles, Reyes-Ureña, Juliana, Ramírez-Viaplana, Ferran, Ruiz, Lidia, Riveira-Muñoz, Eva, Sierra, Alba, Velasco, César, Vivanco-Hidalgo, Rosa M., Sentís, Alexis, G-Beiras, Camila, Clotet, Bonaventura, and Vall-Mayans, Martí
Abstract: No effective treatments for coronavirus disease 2019 (COVID-19) exist. We aimed to determine whether early treatment with hydroxychloroquine (HCQ) would be efficacious for outpatients with COVID-19.
Published: 2021

33. Efficacy of linezolid on Treponema pallidum, the syphilis agent: A preclinical study

Author: Haynes, Austin M., primary, Giacani, Lorenzo, additional, Mayans, Marti Vall, additional, Ubals, Maria, additional, Nieto, Carles, additional, Pérez-Mañá, Clara, additional, Quintó, Llorenç, additional, Romeis, Emily, additional, and Mitjà, Oriol, additional
Published: 2021
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34. A Cluster-Randomized Trial of Hydroxychloroquine for Prevention of Covid-19

Author: Mitjà, Oriol, primary, Corbacho-Monné, Marc, additional, Ubals, Maria, additional, Alemany, Andrea, additional, Suñer, Clara, additional, Tebé, Cristian, additional, Tobias, Aurelio, additional, Peñafiel, Judith, additional, Ballana, Ester, additional, Pérez, Carla A., additional, Admella, Pol, additional, Riera-Martí, Núria, additional, Laporte, Pep, additional, Mitjà, Jordi, additional, Clua, Mireia, additional, Bertran, Laia, additional, Sarquella, Maria, additional, Gavilán, Sergi, additional, Ara, Jordi, additional, Argimon, Josep M., additional, Cuatrecasas, Gabriel, additional, Cañadas, Paz, additional, Elizalde-Torrent, Aleix, additional, Fabregat, Robert, additional, Farré, Magí, additional, Forcada, Anna, additional, Flores-Mateo, Gemma, additional, López, Cristina, additional, Muntada, Esteve, additional, Nadal, Núria, additional, Narejos, Silvia, additional, Nieto, Aroa, additional, Prat, Nuria, additional, Puig, Jordi, additional, Quiñones, Carles, additional, Ramírez-Viaplana, Ferran, additional, Reyes-Urueña, Juliana, additional, Riveira-Muñoz, Eva, additional, Ruiz, Lidia, additional, Sanz, Sergi, additional, Sentís, Alexis, additional, Sierra, Alba, additional, Velasco, César, additional, Vivanco-Hidalgo, Rosa M., additional, Zamora, Juani, additional, Casabona, Jordi, additional, Vall-Mayans, Martí, additional, González-Beiras, Camila, additional, and Clotet, Bonaventura, additional
Published: 2021
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35. Transmission of COVID-19 in 282 clusters in Catalonia, Spain: a cohort study

Author: YoMeCorono, Generalitat de Catalunya, Marks, Michael [0000-0002-7585-4743], Roberts, Chrissy H. [0000-0003-1064-5980], Marks, Michael, Millat-Martinez, Pere, Ouchi, Dan, Roberts, Chrissy H., Alemany, Andrea, Corbacho, Marc, Ubals, Maria, Tobías, Aurelio, Tebé, Cristian, Ballana, Ester, Vall-Mayans, Martí, G-Beiras, Camila, Prat, Nuria, Ara, Jordi, Clotet, Bonaventura, Mitjà, Oriol, YoMeCorono, Generalitat de Catalunya, Marks, Michael [0000-0002-7585-4743], Roberts, Chrissy H. [0000-0003-1064-5980], Marks, Michael, Millat-Martinez, Pere, Ouchi, Dan, Roberts, Chrissy H., Alemany, Andrea, Corbacho, Marc, Ubals, Maria, Tobías, Aurelio, Tebé, Cristian, Ballana, Ester, Vall-Mayans, Martí, G-Beiras, Camila, Prat, Nuria, Ara, Jordi, Clotet, Bonaventura, and Mitjà, Oriol
Abstract: Background There remains limited data on what variables affect risk of transmission of SARS-CoV-2 and developing symptomatic Covid-19 and in particular the relationship to viral load (VL). We analysed data from linked index cases and their contacts to explore factors associated with transmission of SARS-CoV-2. Methods Patients were recruited as part of a randomized control trial, conducted between March to April 2020, that aimed to assess if hydroxychloroquine reduced transmission of SARS-CoV-2. Non-hospitalised Covid-19 cases and their contacts were identified through the local surveillance system. VL, measured by quantitative PCR from a nasopharyngeal swab, was assessed at enrollment, at day 14, and whenever the participant reported Covid-19-like symptoms. Risk of transmission, developing symptomatic disease and incubation dynamics were evaluated using regression analysis. Findings We identified 314 cases, 282 of which had at least one contact (753 contacts in total). Ninety (33%) of 282 clusters had at least one transmission event. The secondary attack rate was 16% (125/753), with a variation from 12% to 24% for VL of the index case of <106, and >109 copies/mL, respectively (OR per log10 increase in VL 1.3 95%CI 1.1–1.6). Increased risk of transmission was also associated with household contact (OR 2.7; 1.4–5.06) and age of the contact (OR 1.02 per year; 1.01–1.04). The proportion of PCR positive contacts who developed symptomatic Covid-19 was 40.3% (181/449), with a variation from 25% to 60% for VL of the contact <107, and >109 copies/mL (HR log10 increase in VL 1.12; 95% CI 1.05 – 1.2). Time to onset of symptomatic disease decreased from a median of 7 days (IQR 5–10) for individuals with an initial viral load <107 to 6 days (4–8) and 5 days (3–8) for individuals with an initial viral load of 107–109 and >109, respectively. Interpretation Viral load of index cases is a leading driver of SARS-CoV-2 transmission. The risk of symptomatic Covid-19 is strongly associ
Published: 2020

36. A Cluster-Randomized Trial of Hydroxychloroquine as Prevention of Covid-19 Transmission and Disease

Author: YoMeCorono, Laboratorios Rubió, Gebro Pharma, Zurich Seguros, SYNLAB, Generalitat de Catalunya, Mitjà, Oriol, Ubals, Maria, Corbacho, Marc, Alemany, Andrea, Suñer, Clara, Tebé, Cristian, Tobías, Aurelio, Peñafiel, Judith, Ballana, Ester, Pérez, Carla, Admella, Pol, Riera-Martí, Núria, Laporte, Pep, Mitjà, Jordi, Clua, Mireia, Bertran, Laia, Sarquella, Maria, Gavilán, Sergi, Ara, Jordi, Argimon, Josep M., Cuatrecasas, Gabriel, Cañadas, Paz, Elizalde-Torrent, Aleix, Fabregat, Robert, Farré, Magí, Forcada, Anna, Flores-Mateo, Gemma, López, Cristina, Muntada, Esteve, Nadal, Núria, Narejos, Silvia, Gil-Ortega, Aroa, Prat, Nuria, Puig, Jordi, Quiñones, Carles, Ramírez-Vilaplana, Ferrán, Reyes-Urueña, Juliana, Riveira-Muñoz, Eva, Ruiz, Lidia, Sanz, Sergi, Sentís, Alexis, Sierra, Alba, Velasco, César, Vivanco-Hidalgo, Rosa M., Zamora, Juani, Casabona, Jordi, Vall-Mayans, Martí, G-Beiras, Camila, Clotet, Bonaventura, YoMeCorono, Laboratorios Rubió, Gebro Pharma, Zurich Seguros, SYNLAB, Generalitat de Catalunya, Mitjà, Oriol, Ubals, Maria, Corbacho, Marc, Alemany, Andrea, Suñer, Clara, Tebé, Cristian, Tobías, Aurelio, Peñafiel, Judith, Ballana, Ester, Pérez, Carla, Admella, Pol, Riera-Martí, Núria, Laporte, Pep, Mitjà, Jordi, Clua, Mireia, Bertran, Laia, Sarquella, Maria, Gavilán, Sergi, Ara, Jordi, Argimon, Josep M., Cuatrecasas, Gabriel, Cañadas, Paz, Elizalde-Torrent, Aleix, Fabregat, Robert, Farré, Magí, Forcada, Anna, Flores-Mateo, Gemma, López, Cristina, Muntada, Esteve, Nadal, Núria, Narejos, Silvia, Gil-Ortega, Aroa, Prat, Nuria, Puig, Jordi, Quiñones, Carles, Ramírez-Vilaplana, Ferrán, Reyes-Urueña, Juliana, Riveira-Muñoz, Eva, Ruiz, Lidia, Sanz, Sergi, Sentís, Alexis, Sierra, Alba, Velasco, César, Vivanco-Hidalgo, Rosa M., Zamora, Juani, Casabona, Jordi, Vall-Mayans, Martí, G-Beiras, Camila, and Clotet, Bonaventura
Abstract: Background Current strategies for preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are limited to non-pharmacological interventions. Hydroxychloroquine (HCQ) has been proposed as a postexposure therapy to prevent Coronavirus disease 2019 (Covid-19) but definitive evidence is lacking. Methods We conducted an open-label, cluster-randomized trial including asymptomatic contacts exposed to a PCR-positive Covid-19 case in Catalonia, Spain. Clusters were randomized to receive no specific therapy (control arm) or HCQ 800mg once, followed by 400mg daily for 6 days (intervention arm). The primary outcome was PCR-confirmed symptomatic Covid-19 within 14 days. The secondary outcome was SARS-CoV-2 infection, either symptomatically compatible or a PCR-positive result regardless of symptoms. Adverse events (AEs) were assessed up to 28 days. Results The analysis included 2,314 healthy contacts of 672 Covid-19 index cases identified between Mar 17 and Apr 28, 2020. A total of 1,198 were randomly allocated to usual care and 1,116 to HCQ therapy. There was no significant difference in the primary outcome of PCR-confirmed, symptomatic Covid-19 disease (6.2% usual care vs. 5.7% HCQ; risk ratio 0.89 [95% confidence interval 0.54-1.46]), nor evidence of beneficial effects on prevention of SARS-CoV-2 transmission (17.8% usual care vs. 18.7% HCQ). The incidence of AEs was higher in the intervention arm than in the control arm (5.9% usual care vs 51.6% HCQ), but no treatment-related serious AEs were reported. Conclusions Postexposure therapy with HCQ did not prevent SARS-CoV-2 disease and infection in healthy individuals exposed to a PCR-positive case. Our findings do not support HCQ as postexposure prophylaxis for Covid-19.
Published: 2020

37. Hydroxychloroquine Alone or in Combination with Cobicistat-Boosted Darunavir for Treatment of Mild COVID-19: A Cluster-Randomized Clinical Trial

Author: YoMeCorono, Laboratorios Rubió, Gebro Pharma, Zurich Seguros, SYNLAB, Generalitat de Catalunya, Mitjà, Oriol, Corbacho, Marc, G-Beiras, Camila, Tebé, Cristian, Tobías, Aurelio, Ballana, Ester, Mitjà, Jordi, Clua, Mireia, Bertran, Laia, Sarquella, Maria, Gavilán, Sergi, Ubals, Maria, Alemany, Andrea, Riera-Martí, Núria, Suñer, Clara, Álvarez, Carla, Laporte, Pep, Admella, Pol, Ara, Jordi, Argimon, Josep M., Casabona, Jordi, Cuatrecasas, Gabriel, Cañadas, Paz, Elizalde-Torrent, Aleix, Fabregat, Robert, Farré, Magí, Forcada, Anna, Flores-Mateo, Gemma, Muntada, Esteve, Nadal, Núria, Narejos, Silvia, Nieto, Aroa, Peñafiel, Judith, Prat, Nuria, Puig, Jordi, Quiñones, Carles, Reyes-Urueña, Juliana, Ramírez-Vilaplana, Ferrán, Ruiz, Lidia, Riveira-Muñoz, Eva, Sierra, Alba, Velasco, César, Vivanco-Hidalgo, Rosa M., Sentís, Alexis, Clotet, Bonaventura, Vall-Mayans, Martí, YoMeCorono, Laboratorios Rubió, Gebro Pharma, Zurich Seguros, SYNLAB, Generalitat de Catalunya, Mitjà, Oriol, Corbacho, Marc, G-Beiras, Camila, Tebé, Cristian, Tobías, Aurelio, Ballana, Ester, Mitjà, Jordi, Clua, Mireia, Bertran, Laia, Sarquella, Maria, Gavilán, Sergi, Ubals, Maria, Alemany, Andrea, Riera-Martí, Núria, Suñer, Clara, Álvarez, Carla, Laporte, Pep, Admella, Pol, Ara, Jordi, Argimon, Josep M., Casabona, Jordi, Cuatrecasas, Gabriel, Cañadas, Paz, Elizalde-Torrent, Aleix, Fabregat, Robert, Farré, Magí, Forcada, Anna, Flores-Mateo, Gemma, Muntada, Esteve, Nadal, Núria, Narejos, Silvia, Nieto, Aroa, Peñafiel, Judith, Prat, Nuria, Puig, Jordi, Quiñones, Carles, Reyes-Urueña, Juliana, Ramírez-Vilaplana, Ferrán, Ruiz, Lidia, Riveira-Muñoz, Eva, Sierra, Alba, Velasco, César, Vivanco-Hidalgo, Rosa M., Sentís, Alexis, Clotet, Bonaventura, and Vall-Mayans, Martí
Abstract: Background: No therapeutics have yet been proven effective for the treatment of mild-illness caused by SARS-CoV-2. We assessed the efficacy and safety of hydroxychloroquine (HCQ) alone or in combination with cobicistat-boosted darunavir (DRVc) for treating patients with mild Covid-19. Methods: We conducted a randomized, prospective, controlled, open-label trial in three health regions of Catalonia. After confirmation of a case of Covid-19 disease, we enumerated on a list a ring of the case and all their contacts and randomly assigned the ring to either control or intervention arm on a 1:1 ratio. Here we present the methods concerning eligible index cases, which involved non-hospitalized adult patients with recently confirmed SARS-CoV-2 infection and less than seven days of symptoms. Patients were assigned to receive HCQ (800 mg on day 1, followed by 400 mg once daily for six days) in combination with DRVc (800 mg/150 mg tablets, once daily for seven days) or no antiviral treatment. The protocol was adapted during the course of the trial to use HCQ alone after findings of no benefit of the protease inhibitor lopinavir-ritonavir. Study outcomes were the reduction of viral RNA load in nasopharyngeal swabs and time to clinical improvement within 28 days of follow-up in the per-protocol population. Adverse events were assessed up to 28 days. Findings: Between Mar 17 and Apr 28, 2020, 353 Covid-19 patients met the criteria for the per-protocol analysis: 165 in the control arm and 142 in the intervention arm. The median time from symptom onset to treatment start was 3 days (IQR 2–4). The per-protocol analysis revealed no significant differences in the mean reduction of viral load in nasopharyngeal swabs at day-3 compared to baseline between the control group (-1·28 Log 10 copies/mL, SD 1·68) and the intervention group (-1·47, SD 1·50); difference -0·18 [95% CI -0.59 to 0·22]. The same pattern was observed at day-7 and -14 after treatment. Time to complete alleviation of sy
Published: 2020

38. Yaws, Haemophilus ducreyi, and Other Bacterial Causes of Cutaneous Ulcer Disease in the South Pacific Islands

Author: G-Beiras, Camila, primary, Ubals, Maria, additional, Corbacho-Monné, Marc, additional, Vall-Mayans, Martí, additional, and Mitjà, Oriol, additional
Published: 2021
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39. Analytical and Clinical Performance of the Panbio COVID-19 Antigen-Detecting Rapid Diagnostic Test

Author: Alemany, Andrea, primary, Baro, Bàrbara, additional, Ouchi, Dan, additional, Ubals, Maria, additional, Corbacho-Monné, Marc, additional, Vergara-Alert, Júlia, additional, Rodon, Jordi, additional, Segalés, Joaquim, additional, Esteban, Cristina, additional, Fernandez, Gema, additional, Ruiz, Lidia, additional, Bassat, Quique, additional, Clotet, Bonaventura, additional, Ara, Jordi, additional, Vall-Mayans, Martí, additional, G-Beiras, Camila, additional, Blanco, Ignacio, additional, and Mitjà, Oriol, additional
Published: 2020
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40. Yaws recurrence in children at continued risk of infection.

Author: González-Beiras, Camila, Marks, Michael, Quintó, Llorenç, Gavilán, Sergi, Kolmau, Reman, Ubals, Maria, Vall-Mayans, Marti, and Mitjà, Oriol
Subjects: BURULI ulcer, SYPHILIS, HEALTH facilities, ELECTRONIC health records, NEGLECTED diseases, SERODIAGNOSIS, WATCHFUL waiting
Abstract: Background: In yaws-endemic areas, children with Treponema pallidum subsp. pertenue infection may suffer recurrent episodes due to either reinfection or relapse. However, the possibility of infection with other cutaneous ulcer causative agents and difficulties in interpreting standard laboratory results challenges the estimation of yaws recurrence rates. Methods: We estimated the rates of yaws recurrences in the Lihir Island (Papua New Guinea) using two approaches: passive surveillance based on a retrospective screening of electronic medical records of cutaneous ulcers diagnosed using serological testing between 2005 and 2016, and active surveillance conducted during a cross-sectional prevalence study which included PCR analyses of ulcers of all suspected cases of yaws. The risk of recurrent infection was assessed based on data from the passive surveillance analysis and using two Cox regression models (crude and multivariate), stratified by year of index episode. Data gathered from the active surveillance was used to characterize the recurrences and no hypothesis testing was performed. Results: The electronic medical records included 6,125 patients (7,889 ulcer episodes) with documented serological results of cutaneous ulcers of which1,486 were diagnosed with yaws. Overall, 1,246/6,125 patients (20.3%) presented more than once with a cutaneous ulcer, and 103/1,486 (6.7%) patients had multiple episodes of yaws. The risk of yaws recurrence significantly increased with age and was higher in patients with ≥3 recurrent episodes. In the active surveillance, we identified 50 individuals with recurrent cutaneous ulcer that had PCR results available for both the index and recurrent episode. Of 12 individuals with T. pallidum in the index ulcer, 8 (66%) had T. pallidum in subsequent assessments, relapse related to macrolide-resistance was identified in two of these cases. Conclusions: Our results confirm the need for active follow-up of yaws patients after treatment, particularly children and individuals with a history of recurrence. Author summary: Yaws is a neglected tropical disease produced by Treponema pallidum pertenue that causes skin ulcers in children living in remote rural areas of the South Pacific and West Africa. Children aged 5–15 and individuals with a history of recurrence are at higher risk of reinfection. Although yaws can be treated with single-dose azithromycin, some children present with recurrent cutaneous ulcers; however, the prevalence and risk factors for yaws recurrence are poorly known. Our analysis of skin ulcers in Papua New Guinea revealed that up to 20% of patients who presented to a health care facility in the Lihir island of Papua New Guinea with a cutaneous ulcer experienced a recurrent episode within the 6–36 months following treatment. Nearly all individuals with recurrent yaws were children aged 15 years or younger. Besides age, the number of previous ulcers was associated with a higher risk of recurrence. The molecular analysis revealed that among cases with T. pallidum at baseline that had a recurrence, this was often related to reinfection with the same microorganism. Our results confirm the need for active follow-up of young children diagnosed with cutaneous ulcers, with particular attention to those with younger age and previous history of recurrences. [ABSTRACT FROM AUTHOR]
Published: 2022
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41. Transmission of COVID-19 in 282 clusters in Catalonia, Spain: a cohort study

Author: Marks, Michael, primary, Millat-Martinez, Pere, additional, Ouchi, Dan, additional, Roberts, Chrissy h., additional, Alemany, Andrea, additional, Corbacho-Monné, Marc, additional, Ubals, Maria, additional, Tobias, Aurelio, additional, Tebé, Cristian, additional, Ballana, Ester, additional, Vall-Mayans, Martí, additional, G-Beiras, Camila, additional, Prat, Nuria, additional, Ara, Jordi, additional, Clotet, Bonaventura, additional, and Mitjà, Oriol, additional
Published: 2020
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42. A Cluster-Randomized Trial of Hydroxychloroquine as Prevention of Covid-19 Transmission and Disease

Author: Mitjà, Oriol, primary, Ubals, Maria, additional, Corbacho-Monné, Marc, additional, Alemany, Andrea, additional, Suñer, Clara, additional, Tebe, Cristian, additional, Tobias, Aurelio, additional, Peñafiel, Judith, additional, Ballana, Ester, additional, Pérez, Carla A., additional, Admella, Pol, additional, Riera-Martí, Nuria, additional, Laporte, Pep, additional, Mitja, Jordi, additional, Clua, Mireia, additional, Bertran, Laia, additional, Sarquella, Maria, additional, Gavilán, Sergi, additional, Ara, Jordi, additional, Argimon, Josep M, additional, Cuatrecasas, Gabriel, additional, Cañadas, Paz, additional, Elizalde-Torrent, Aleix, additional, Fabregat, Robert, additional, Farré, Magí, additional, Forcada, Anna, additional, Flores-Mateo, Gemma, additional, López, Cristina, additional, Muntada, Esteve, additional, Nadal, Núria, additional, Narejos, Silvia, additional, Gil-Ortega, Aroa N, additional, Prat, Nuria, additional, Puig, Jordi, additional, Quiñones, Carles, additional, Ramírez-Viaplana, Ferran, additional, Urueña, Juliana Reyes-, additional, Riveira-Muñoz, Eva, additional, Ruiz, Lidia, additional, Sanz, Sergi, additional, Sentis, Alexis, additional, Sierra, Alba, additional, Velasco, César, additional, Vivanco-Hidalgo, Rosa Maria, additional, Zamora, Juani, additional, Casabona, Jordi, additional, Vall-Mayans, Martí, additional, G-Beiras, Camila, additional, and Clotet, Bonaventura, additional
Published: 2020
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43. Hydroxychloroquine for Early Treatment of Adults With Mild Coronavirus Disease 2019: A Randomized, Controlled Trial

Author: Mitjà, Oriol, primary, Corbacho-Monné, Marc, additional, Ubals, Maria, additional, Tebé, Cristian, additional, Peñafiel, Judith, additional, Tobias, Aurelio, additional, Ballana, Ester, additional, Alemany, Andrea, additional, Riera-Martí, Núria, additional, Pérez, Carla A, additional, Suñer, Clara, additional, Laporte, Pep, additional, Admella, Pol, additional, Mitjà, Jordi, additional, Clua, Mireia, additional, Bertran, Laia, additional, Sarquella, Maria, additional, Gavilán, Sergi, additional, Ara, Jordi, additional, Argimon, Josep M, additional, Casabona, Jordi, additional, Cuatrecasas, Gabriel, additional, Cañadas, Paz, additional, Elizalde-Torrent, Aleix, additional, Fabregat, Robert, additional, Farré, Magí, additional, Forcada, Anna, additional, Flores-Mateo, Gemma, additional, Muntada, Esteve, additional, Nadal, Núria, additional, Narejos, Silvia, additional, Nieto, Aroa, additional, Prat, Nuria, additional, Puig, Jordi, additional, Quiñones, Carles, additional, Reyes-Ureña, Juliana, additional, Ramírez-Viaplana, Ferran, additional, Ruiz, Lidia, additional, Riveira-Muñoz, Eva, additional, Sierra, Alba, additional, Velasco, César, additional, Vivanco-Hidalgo, Rosa Maria, additional, Sentís, Alexis, additional, G-Beiras, Camila, additional, Clotet, Bonaventura, additional, and Vall-Mayans, Martí, additional
Published: 2020
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44. Hydroxychloroquine Alone or in Combination with Cobicistat-Boosted Darunavir for Treatment of Mild COVID-19: A Cluster-Randomized Clinical Trial

Author: Mitjà, Oriol, primary, Corbacho, Marc, additional, G-Beiras, Camila, additional, Tebé, Cristian, additional, Tobias, Aurelio, additional, Ballana, Ester, additional, Mitjà, Jordi, additional, Clua, Mireia, additional, Bertran, Laia, additional, Sarquella, Maria, additional, Gavilán, Sergi, additional, Ubals, Maria, additional, Alemany, Andrea, additional, Riera-Martí, Núria, additional, Suñer, Clara, additional, Álvarez, Carla, additional, Laporte, Pep, additional, Admella, Pol, additional, Ara, Jordi, additional, Argimon, Josep M., additional, Casabona, Jordi, additional, Cuatrecasas, Gabriel, additional, Cañadas, Paz, additional, Elizalde-Torrent, Aleix, additional, Fabregat, Robert, additional, Farré, Magí, additional, Forcada, Anna, additional, Flores-Mateo, Gemma, additional, Muntada, Esteve, additional, Nadal, Núria, additional, Narejos, Silvia, additional, Nieto, Aroa, additional, Peñafiel, Judith, additional, Prat, Nuria, additional, Puig, Jordi, additional, Quiñones, Carles, additional, Reyes-Urueña, Juliana, additional, Ramírez-Vilaplana, Ferran, additional, Ruiz, Lidia, additional, Riveira-Muñoz, Eva, additional, Sierra, Alba, additional, Velasco, César, additional, Vivanco-Hidalgo, Rosa Maria, additional, Sentís, Alexis, additional, Clotet, Bonaventura, additional, and Vall-Mayans, Martí, additional
Published: 2020
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45. Hydroxychloroquine for Early Treatment of Adults With Mild Coronavirus Disease 2019: A Randomized, Controlled Trial.

Author: Mitjà, Oriol, Corbacho-Monné, Marc, Ubals, Maria, Tebé, Cristian, Peñafiel, Judith, Tobias, Aurelio, Ballana, Ester, Alemany, Andrea, Riera-Martí, Núria, Pérez, Carla A, Suñer, Clara, Laporte, Pep, Admella, Pol, Mitjà, Jordi, Clua, Mireia, Bertran, Laia, Sarquella, Maria, Gavilán, Sergi, Ara, Jordi, and Argimon, Josep M
Subjects: RESEARCH, COVID-19, VIRAL load, TIME, MEDICAL cooperation, TREATMENT effectiveness, RANDOMIZED controlled trials, DESCRIPTIVE statistics, HOSPITAL care, HYDROXYCHLOROQUINE, STATISTICAL sampling, EARLY medical intervention, EVALUATION, ADULTS
Abstract: Background No effective treatments for coronavirus disease 2019 (COVID-19) exist. We aimed to determine whether early treatment with hydroxychloroquine (HCQ) would be efficacious for outpatients with COVID-19. Methods Multicenter open-label, randomized, controlled trial conducted in Catalonia, Spain, between 17 March and 26 May 2020. Patients recently diagnosed with <5-day of symptom onset were assigned to receive HCQ (800 mg on day 1 followed by 400 mg once daily for 6 days) or usual care. Outcomes were reduction of viral load in nasopharyngeal swabs up to 7 days after treatment start, disease progression up to 28 days, and time to complete resolution of symptoms. Adverse events were assessed up to 28 days. Results A total of 293 patients were eligible for intention-to-treat analysis: 157 in the control arm and 136 in the intervention arm. The mean age was 41.6 years (SD, 12.6), mean viral load at baseline was 7.90 log10 copies/mL (SD, 1.82), and median time from symptom onset to randomization was 3 days. No differences were found in the mean reduction of viral load at day 3 (−1.41 vs −1.41 log10 copies/mL in the control and intervention arm, respectively) or at day 7 (−3.37 vs −3.44). Treatment did not reduce risk of hospitalization (7.1% control vs 5.9% intervention) nor shorten the time to complete resolution of symptoms (12 days, control vs 10 days, intervention). No relevant adverse events were reported. Conclusions In patients with mild COVID-19, no benefit was observed with HCQ beyond the usual care. [ABSTRACT FROM AUTHOR]
Published: 2021
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46. Leishmaniasis and tumor necrosis factor alpha antagonists in the Mediterranean basin. A switch in clinical expression

Author: Bosch-Nicolau, Pau, Ubals, Maria, Salvador, Fernando, Sánchez-Montalvá, Adrián, Aparicio, Gloria, Erra Duran, Alba, Martínez de Salazar, Pablo, Sulleiro Igual, Elena, Molina Romero, Israel, Universitat Autònoma de Barcelona, [Bosch-Nicolau P, Salvador F, Sánchez-Montalvá A, Molina I] Servei de Malalties Infeccioses, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Programa de salut internacional de l'Institut Català de la Salut (PROSICS), ICS, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Ubals M, Aparicio G] Servei de Dermatologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Erra A] Servei de Reumatologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Martinez de Salazar P, Sulleiro E] Servei de Microbiologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Programa de salut internacional de l'Institut Català de la Salut (PROSICS), ICS, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
Subjects: 0301 basic medicine, Male, Physiology, Biopsy, RC955-962, Gastroenterology, Etanercept, Medicaments antineoplàstics, 0302 clinical medicine, Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Cohort Studies::Retrospective Studies [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Bone Marrow, Recurrence, Zoonoses, Immune Physiology, Arctic medicine. Tropical medicine, Medicine and Health Sciences, Child, Leishmaniasis, Protozoans, Leishmania, Aged, 80 and over, Innate Immune System, Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Leishmaniasis [DISEASES], Mediterranean Region, Eukaryota, Middle Aged, Infectious Diseases, enfermedades parasitarias::infecciones por protozoos::infecciones por Euglenozoa::leishmaniosis [ENFERMEDADES], Cytokines, Raonament basat en casos, Female, Public aspects of medicine, RA1-1270, Immunosuppressive Agents, medicine.drug, Research Article, Neglected Tropical Diseases, aminoácidos, péptidos y proteínas::péptidos::péptidos y proteínas de señalización intercelular::citocinas::monocinas::factor de necrosis tumoral alfa [COMPUESTOS QUÍMICOS Y DROGAS], Adult, medicine.medical_specialty, Adolescent, Leishmania Infantum, 030231 tropical medicine, Immunology, técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::estudios de cohortes::estudios retrospectivos [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Surgical and Invasive Medical Procedures, Rheumatoid Arthritis, Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Monokines::Tumor Necrosis Factor-alpha [CHEMICALS AND DRUGS], Injections, Intramuscular, Autoimmune Diseases, 03 medical and health sciences, Young Adult, Cutaneous leishmaniasis, Rheumatology, Leishmaniosi, Internal medicine, medicine, Adalimumab, Parasitic Diseases, Humans, Aged, Retrospective Studies, Miltefosine, Protozoan Infections, business.industry, Tumor Necrosis Factor-alpha, Arthritis, Public Health, Environmental and Occupational Health, Organisms, Biology and Life Sciences, Molecular Development, medicine.disease, Tropical Diseases, Infliximab, Golimumab, Parasitic Protozoans, 030104 developmental biology, Visceral leishmaniasis, Immune System, Clinical Immunology, Clinical Medicine, business, Developmental Biology, Systematic Reviews as Topic
Abstract: Background Tumor necrosis factor alpha (TNF-α) blockers are recognized as a risk factor for reactivation of granulomatous infections. Leishmaniasis has been associated with the use of these drugs, although few cases have been reported. Methodology We performed a retrospective observational study including patients with confirmed leishmaniasis acquired in the Mediterranean basin that were under TNF-α blockers therapy at the moment of the diagnosis. Patients diagnosed in our hospital from 2008 to 2018 were included. Moreover, a systematic review of the literature was performed and cases fulfilling the inclusion criteria were also included. Principal findings Forty-nine patients were analyzed including nine cases from our series. Twenty-seven (55.1%) cases were male and median age was 55 years. Twenty-five (51%) patients were under infliximab treatment, 20 (40.8%) were receiving adalimumab, 2 (4.1%) etanercept, one (2%) golimumab and one (2%) a non-specified TNF-α blocker. Regarding clinical presentation, 28 (57.1%) presented as cutaneous leishmaniasis (CL), 16 (32.6%) as visceral leishmaniasis (VL) and 5 (10.2%) as mucocutaneous leishmaniasis (MCL). All VL and MCL patients were treated with systemic therapies. Among CL patients, 13 (46.4%) were treated with a systemic drug (11 received L-AmB, one intramuscular antimonials and one miltefosine) while 14 (50%) patients were given local treatment (13 received intralesional pentavalent antimonials, and one excisional surgery). TNF-α blockers were interrupted in 32 patients (65.3%). After treatment 5 patients (10.2%) relapsed. Four patients with a CL (3 initially treated with local therapy maintaining TNF-α blockers and one treated with miltefosine) and one patient with VL treated with L-AmB maintaining TNF-α blockers. Conclusions This data supports the assumption that the blockage of TNF-α modifies clinical expression of leishmaniasis in endemic population modulating the expression of the disease leading to atypical presentations. According to the cases reported, the best treatment strategy would be a systemic drug and the discontinuation of the TNF-α blockers therapy until clinical resolution., Author summary Tumor necrosis factor alpha (TNF-α) blockers are widely used in numerous inflammatory diseases such rheumatoid arthritis, psoriasis or inflammatory bowel diseases. They have been recognized as a risk factor for reactivation of granulomatous infections. Although few cases have been reported, Leishmaniasis has been associated with the use of these drugs. Leishmania infantum is the main causative agent of leishmaniasis in Southern Europe and is prone to produce the visceral form. However, TNF-α has been implicated in the initial events of the infection mediating the disease expression. In our series, we have observed a surprisingly high proportion of cutaneous form (32.6%) and muco-cutaneous form (10.2%). Clinical outcome observed in this series is also unusual. Four cases (14.3%) with cutaneous leishmaniasis who received local therapy relapsed. Among patients with visceral leishmaniasis, one patient who maintained TNF-α blockers therapy relapsed despite etiological treatment. This data supports the assumption that the blockage of TNF-α modifies clinical expression of leishmaniasis leading to atypical presentations. According to the cases reported we proposed as best treatment strategy a systemic drug and the discontinuation of the TNF-α blockers therapy until clinical resolution.
Published: 2019

47. Leishmaniasis and tumor necrosis factor alpha antagonists in the Mediterranean basin. A switch in clinical expression

Author: Bosch-Nicolau, Pau, primary, Ubals, Maria, additional, Salvador, Fernando, additional, Sánchez-Montalvá, Adrián, additional, Aparicio, Gloria, additional, Erra, Alba, additional, Martinez de Salazar, Pablo, additional, Sulleiro, Elena, additional, and Molina, Israel, additional
Published: 2019
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48. Etiological Characterization of the Cutaneous Ulcer Syndrome in Papua New Guinea Using Shotgun Metagenomics

Author: Noguera-Julian, Marc, primary, González-Beiras, Camila, additional, Parera, Mariona, additional, Ubals, Maria, additional, Kapa, August, additional, Paredes, Roger, additional, and Mitjà, Oriol, additional
Published: 2018
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49. Etiological Characterization of the Cutaneous Ulcer Syndrome in Papua New Guinea Using Shotgun Metagenomics.

Author: Noguera-Julian, Marc, González-Beiras, Camila, Parera, Mariona, Ubals, Maria, Kapa, August, Paredes, Roger, and Mitjà, Oriol
Subjects: YAWS, DNA analysis, BEJEL, CLUSTER analysis (Statistics), CORYNEBACTERIUM diseases, GRAM-positive bacteria, HAEMOPHILUS diseases, LONGITUDINAL method, MICROBIOLOGICAL techniques, POLYMERASE chain reaction, GENOMICS, DESCRIPTIVE statistics, SEQUENCE analysis, SKIN ulcers, DISEASE complications, PREVENTION
Abstract: Background Treponema pallidum subsp pertenue and Haemophilus ducreyi are causative agents of cutaneous ulcer (CU) in yaws-endemic regions in the tropics. However, a significant proportion of CU patients remain polymerase chain reaction (PCR) negative for both bacterial agents. We aimed to identify potential additional etiological agents of CU in a yaws-endemic region. Methods This population-based cohort study included children in Lihir Island (Papua New Guinea) examined during a yaws eradication campaign in October 2013–October 2014. All consenting patients with atraumatic exudative ulcers of >1 cm diameter were enrolled. Lesional swabs were collected for real-time PCR testing for T. pallidum subsp pertenue and H. ducreyi. We then performed shotgun whole DNA metagenomics sequencing on extracted DNA and taxonomically assigned shotgun sequences using a human microbiome reference. Results Sequence data were available for 122 samples. Shotgun sequencing showed high classification agreement relative to PCR testing (area under the curve for T. pallidum/H. ducreyi was 0.92/0.85, respectively). Clustering analysis of shotgun data revealed compositional clusters where the dominant species (median relative abundance ranged from 32% to 66%) was H. ducreyi (23% of specimens), T. pallidum subsp pertenue (16%), Streptococcus dysgalactiae (12%), Arcanobacterium haemolyticum (8%), and Corynebacterium diphtheriae (8%). Sample clustering derived from ulcer microbial composition did not show geographical patterns. Conclusions These data suggest a diverse etiology of skin ulcers in yaws-endemic areas, which may help design more accurate diagnostic tools and more effective antimicrobial treatment approaches to the cutaneous ulcer syndrome. [ABSTRACT FROM AUTHOR]
Published: 2019
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50. High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial

Author: Alemany, Andrea, Millat-Martinez, Pere, Corbacho-Monné, Marc, Malchair, Pierre, Ouchi, Dan, Ruiz-Comellas, Anna, Ramírez-Morros, Anna, Rodríguez Codina, Joana, Amado Simon, Rosa, Videla, Sebastian, Costes, Gèlia, Capdevila-Jáuregui, Mar, Torrano-Soler, Pamela, San José, Alba, Bonet Papell, Glòria, Puig, Jordi, Otero, Aurema, Ruibal Suarez, Jose Carlos, Zarauza Pellejero, Alvaro, Llopis Roca, Ferran, Rodriguez Cortez, Orlando, Garcia Garcia, Vanesa, Vidal-Alaball, Josep, Millan, Anna, Contreras, Enric, Grifols, Joan-Ramon, Ancochea, Àgueda, Galvan-Femenia, Ivan, Piccolo Ferreira, Francini, Bonet, Mireia, Cantoni, Jordi, Prat, Núria, Ara, Jordi, Forcada Arcarons, Anna, Farré, Magí, Pradenas, Edwards, Blanco, Julià, Àngel Rodriguez-Arias, Miquel, Fernández Rivas, Gema, Marks, Michael, Bassat, Quique, Blanco, Ignacio, Baro, Bàrbara, Clotet, Bonaventura, Mitjà, Oriol, Ferrer, Susana, Gallardo, Mireia, Ubals, Maria, González-Beiras, Camila, Vall-Mayans, Martí, Suñer, Clara, Laporte-Villar, Clàudia, Nieto, Aroa, Comas-Leon, Xavier, Jiménez, Zahida, Ramírez-Viaplana, Ferran, Delgado-Capel, Maria, Díez Sánchez, Beatriz, Pons Barber, Maria, Gonzalez Ruiz, Cristian, Navarrete Gonzalez, Laura, González García, David, Vivero Larraza, Ainhoa, Carceles Peiró, Victor, Roquer López, Clàudia, Robert, Neus, Palet, Carles, Gudiol, Carlota, Casares Gonzalez, Pablo, Arcos Vila, Gemma, Flores Aguilera, Begoña, Rodríguez-Sevilla, Graciela, Dastis Arias, Macarena, Roca Font, Judit, Carrasco Matos, Katherine M., Saüch Valmaña, Glòria, Vidal Obradors, Carla, Tarres García, Silvia, Curriu Sabatès, Margarida, Nieto Rodríguez, Raquel, Línio, Rosa, Fornos, Míriam, Casamitjana, Natàlia, Alonso, Eva, Martínez, Núria, Maglio, Laura Analía, Comellas Fernandez, Laura, Garcia, Nadia, Hernández, Luis, González, Maria Isabel, Bravo, Anna, García, Yolanda, Sauleda Oliveras, Silvia, Vertiz, Tatiana, Benavent, Sergio, Bianco, Andrea Sofia, Verdaguer, Joaquim, Briones Zambrano, Ney Nicanor, Viozquez Meya, Maria, Hernández, Águeda, Casaña Lopez, Cristina, Bordoy, Antoni E., González Soler, Victoria, Giménez, Montserrat, París, Alexa, Marfil, Silvia, Trinité, Benjamin, and Grau, Eulàlia
Abstract: Convalescent plasma has been proposed as an early treatment to interrupt the progression of early COVID-19 to severe disease, but there is little definitive evidence. We aimed to assess whether early treatment with convalescent plasma reduces the risk of hospitalisation and reduces SARS-CoV-2 viral load among outpatients with COVID-19.
Published: 2024
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