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High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial

Authors :
Alemany, Andrea
Millat-Martinez, Pere
Corbacho-Monné, Marc
Malchair, Pierre
Ouchi, Dan
Ruiz-Comellas, Anna
Ramírez-Morros, Anna
Rodríguez Codina, Joana
Amado Simon, Rosa
Videla, Sebastian
Costes, Gèlia
Capdevila-Jáuregui, Mar
Torrano-Soler, Pamela
San José, Alba
Bonet Papell, Glòria
Puig, Jordi
Otero, Aurema
Ruibal Suarez, Jose Carlos
Zarauza Pellejero, Alvaro
Llopis Roca, Ferran
Rodriguez Cortez, Orlando
Garcia Garcia, Vanesa
Vidal-Alaball, Josep
Millan, Anna
Contreras, Enric
Grifols, Joan-Ramon
Ancochea, Àgueda
Galvan-Femenia, Ivan
Piccolo Ferreira, Francini
Bonet, Mireia
Cantoni, Jordi
Prat, Núria
Ara, Jordi
Forcada Arcarons, Anna
Farré, Magí
Pradenas, Edwards
Blanco, Julià
Àngel Rodriguez-Arias, Miquel
Fernández Rivas, Gema
Marks, Michael
Bassat, Quique
Blanco, Ignacio
Baro, Bàrbara
Clotet, Bonaventura
Mitjà, Oriol
Ferrer, Susana
Gallardo, Mireia
Ubals, Maria
González-Beiras, Camila
Vall-Mayans, Martí
Suñer, Clara
Laporte-Villar, Clàudia
Nieto, Aroa
Comas-Leon, Xavier
Jiménez, Zahida
Ramírez-Viaplana, Ferran
Delgado-Capel, Maria
Díez Sánchez, Beatriz
Pons Barber, Maria
Gonzalez Ruiz, Cristian
Navarrete Gonzalez, Laura
González García, David
Vivero Larraza, Ainhoa
Carceles Peiró, Victor
Roquer López, Clàudia
Robert, Neus
Palet, Carles
Gudiol, Carlota
Casares Gonzalez, Pablo
Arcos Vila, Gemma
Flores Aguilera, Begoña
Rodríguez-Sevilla, Graciela
Dastis Arias, Macarena
Roca Font, Judit
Carrasco Matos, Katherine M.
Saüch Valmaña, Glòria
Vidal Obradors, Carla
Tarres García, Silvia
Curriu Sabatès, Margarida
Nieto Rodríguez, Raquel
Línio, Rosa
Fornos, Míriam
Casamitjana, Natàlia
Alonso, Eva
Martínez, Núria
Maglio, Laura Analía
Comellas Fernandez, Laura
Garcia, Nadia
Hernández, Luis
González, Maria Isabel
Bravo, Anna
García, Yolanda
Sauleda Oliveras, Silvia
Vertiz, Tatiana
Benavent, Sergio
Bianco, Andrea Sofia
Verdaguer, Joaquim
Briones Zambrano, Ney Nicanor
Viozquez Meya, Maria
Hernández, Águeda
Casaña Lopez, Cristina
Bordoy, Antoni E.
González Soler, Victoria
Giménez, Montserrat
París, Alexa
Marfil, Silvia
Trinité, Benjamin
Grau, Eulàlia
Source :
The Lancet Respiratory Medicine; 20240101, Issue: Preprints
Publication Year :
2024

Abstract

Convalescent plasma has been proposed as an early treatment to interrupt the progression of early COVID-19 to severe disease, but there is little definitive evidence. We aimed to assess whether early treatment with convalescent plasma reduces the risk of hospitalisation and reduces SARS-CoV-2 viral load among outpatients with COVID-19.

Details

Language :
English
ISSN :
22132600 and 22132619
Issue :
Preprints
Database :
Supplemental Index
Journal :
The Lancet Respiratory Medicine
Publication Type :
Periodical
Accession number :
ejs58892996
Full Text :
https://doi.org/10.1016/S2213-2600(21)00545-2