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Introduction: Electroencephalography (EEG) microstates are successive short time periods of stable scalp field potentials that represent spontaneous activation of brain resting-state networks. EEG microstates are assumed to mediate local activity patterns. To assess this hypothesis, we correlated momentary EEG microstate dynamics with the temporo-spectral evolution of electrocorticography (ECoG) and stereotactic EEG(SEEG) depth electrode recordings. Methods We analyzed resting-state data (5 min) from two participants with simultaneous noninvasive scalp EEG and invasive ECoG, and SEEG recordings. Data were recorded during the presurgical evaluation of pharmacoresistant epilepsusing subdural and intracranial electrodes. After standard preprocessing, we fitted microstate template maps to the scalp EEG data. Using covariance mapping with EEG microstate timelines and ECoG/SEEG temporo-spectral evolutions as input, we identified systematic changes in the activation of ECoG/SEEG local field potentials in different frequency bands (theta, alpha, beta, and high gamma) depending on the presence of a particular microstate class. Results We found a significant covariation of ECoG/SEEG spectral amplitudes with microstate timelines in all four frequency bands (p = .001, permutation test). The covariance patterns of the ECoG/SEEG electrodes during different microstates were similar for the two observed participants. Discussion To our knowledge, this is the first study to demonstrate distinct activation/deactivation patterns of frequency-domain ECoG local field potentials associated with simultaneously present EEG microstates.

AIM OF THE STUDY: Previous literature suggests that ambient temperature may play a role in increasing the risk of suicide. Although in Switzerland suicides are an important cause of death, limited research exists on risk factors for suicidal behaviour, including ambient temperature. We aimed to assess the short-term association between ambient temperature and suicide risk in Switzerland between 1995 and 2016, and the differences by region, individual characteristics and method of suicide. METHODS: We collected daily data on suicides and mean temperatures in each canton of Switzerland. We used a two-stage approach, consisting of a case time series analysis using conditional quasi-Poisson and distributed lag non-linear models followed by a multivariate meta-regression analysis. We conducted subgroup analyses by sex, age (65 years) and method of suicide (violent or nonviolent). RESULTS: Between 1995 and 2016, there were a total of 24,067 suicides in Switzerland. Overall, we found a positive and non-linear temperature–suicide association in all regions. On average, the risk of suicide increased by 34% (1.34 relative risk [95% confidence interval: 1.19–1.52]) from the 10th to the 99th temperature percentile in Switzerland (lag period of 0–2 days). Indications of larger risks were mostly found in females, younger individuals (

Psychiatric patients are particularly vulnerable to strong weather stimuli, such as foehn, a hot wind that occurs in the alps. However, there is a dearth of research regarding its impact on mental health. This study investigated the impact of foehn wind among patients of a psychiatric hospital located in a foehn area in the Swiss Alps. Analysis was based on anonymized datasets obtained from routine records on admission and discharge, including the Brief Symptom Checklist (BSCL) questionnaire, as well as sociodemographic parameters (age, sex, and diagnosis). Between 2013 and 2020 a total of 10,456 admission days and 10,575 discharge days were recorded. All meteorological data were extracted from the database of the Federal Office of Meteorology and Climatology of Switzerland. We estimated the effect of foehn on the BSCL items using a distributed lag model. Significant differences were found between foehn and non-foehn admissions in obsession-compulsion, Interpersonal Sensitivity, depression, Anxiety, Phobic Anxiety, Paranoid Ideation, and General Severity Index (GSI) (p

A relatively high proportion of attempted suicides employ self-poisoning with medication. Data from emergency department presentations can help to identify possible risk drug classes and provide a basis for preventive measures. This retrospective analysis included cases presenting at the emergency department of the University Hospital of Bern, Switzerland, from May 2012 to August 2016, after attempted suicide with drugs. We excluded attempted suicides with only alcohol or other non-medical substances. During the study period, there were 488 cases (466 patients) of attempted suicide with medical substances. The median patient age was 33 years (range 16–93) and 354 (73%) cases were female. The most commonly involved substances/drug classes were benzo-diazepines (n = 167, 34%), neuroleptics (n = 114, 23%) and paracetamol (n = 111, 23%). A total of 231 (47%) cases employed only a single substance. Common symptoms included somnolence (n = 245, 50%), tachycardia (n = 119, 24%) and nausea/vomiting (n = 76, 16%). In most cases, the poisoning was of minor severity (n = 231, 47%) and the patients were admitted to a psychiatric hospital (n = 264, 54%). Important preventive measures may include careful monitoring for suicidal behaviour when prescribing psychotropic drugs, in addition to restrictions in pack size. Efforts should also be made to enhance the awareness of health professionals qualified to prescribe or supply paracetamol.

The Herschel Space Observatory had two imaging instruments, working in the far-infrared and submillimetre regimes: the PACS cameras at 70/100 and 160 μm and the SPIRE photometers at 250, 350 and 500 μm. Small solar system bodies, especially main belt asteroids were serendipitously present in the field of view mainly in large scan maps. We identified these objects with the original aim to mark the affected sources in the Herschel PACS and SPIRE Point Source Catalogues. In our present study we extracted flux densities in the PACS bands for asteroids above the detection limit, either using existing standard data products from the Herschel Science Archive, or re-reducing the PACS maps in the co-moving frame of the target. We obtained ~600 new flux density values for 270 asteroids, a significant increase in the number of Herschel asteroid observations. These new flux densities will be included in the Small Bodies: Near and Far (SBNAF) Infrared Database (Szakáts et al., 2020). The fluxes obtained from Herschel are excellent for radiometric studies to get the object's size, albedo and maybe also thermal properties, when combined with other measurements (Alí-Lagoa et al., 2020).

Asteroids (24) Themis and (65) Cybele have an absorption feature at 3.1 µm reported to be directly linked to surface water ice. We searched for water vapour escaping from these asteroids with the Herschel Space Observatory Heterodyne Instrument for the Far Infrared (HIFI). While no H2O line emission was detected, we obtain sensitive 3σ water production rate upper limits of Q(H2O) < 4.1 × 1026 mol. s−1 for Themis and Q(H2O) < 7.6 × 1026 mol. s−1 for Cybele. Using a Thermophysical Model (TPM), we merge data from Subaru/Comics and Herschel/SPIRE with the contents of a multi-observatory database to derive new radiometric properties for these two asteroids. For Themis, we find a thermal inertia Γ = 20+25-10 J m-2 s-1/2 K-1, a diameter 192 +10-7 km and a geometric V-band albedo pV = 0.07 ±0.01. For Cybele we obtain a thermal inertia Γ = 25 +28-19 J m-2 s-1/2 K-1, a diameter 282 ± 9 km, and an albedo pV = 0.042± 0.005. Using all inputs, we estimate that water ice intimately mixed with the asteroids’ dark surface material would cover < 0.0017% for Themis and < 0.0033% for Cybele of their surfaces, while an areal mixture with very clean ice (bond albedo 0.8 for Themis and 0.7 for Cybele) would cover < 2.2% for Themis and < 1.5% for Cybele, of their surfaces. While surface (& sub-surface) water ice may exist in small localized amounts on both asteroids, it is not the reason for the observed 3.1µm absorption feature.

Background Previous studies suggest that people with mental disorders are more vulnerable to increased ambient temperatures (AT). In Switzerland, neuropsychiatric diseases contribute up to 35.1% of the total burden of disease. This burden could possibly increase in the future under current climate change scenarios, if no appropriate public health measures were implemented. However, there is lack of evidence on the impact of AT on mental health in Switzerland. Objective This study aimed to investigate the short-term association between AT and mental health hospitalizations in Bern, Switzerland. Methods From 1973 to 2010, we collected individual data on daily hospitalizations for mental disorders (71,931) from the University Hospital of Psychiatry and Psychotherapy in Bern. We used population-weighted daily mean AT for the canton of Bern derived from the 2.2-km gridded weather data provided by MeteoSwiss. We applied conditional Poisson regression with distributed lag linear models to assess the association and to account for delayed effects up to 3 days after the exposure. We conducted stratified analysis and by age, sex and diagnosis. Results The overall risk of hospitalizations increased linearly by 3.0% (95% CI: 0.0%, 6.0%) for every 10C°C-increase in mean daily AT. No differences in risk estimates were found across sex (3.0% in males (95% CI: 0%, 7.0%) and 4.0% in females (95% CI: 0%, 8.0%)) and age groups (≥ 45 years old: 4.0% (95% CI: 0%, 9.0%) and Conclusions Our preliminary findings suggest that increasing AT are associated with an increased risk in hospitalizations due to mental disorders in Bern. Specific public health policies should be urgently implemented in order to protect this vulnerable population sub-group from the challenges of climate change. Key messages Increased ambient temperatures are associated with an increased risk in hospitalizations due to mental health disorders. Specific health policies should be implement to protect mental health patients from the challenges of climate change.

The effects of current and expected future climate change on mental health outcomes are of increasing concern. In this context, the importance of meteorological factors on suicidal behavior is receiving growing attention in research.Systematic review article with qualitative synthesis of the currently available literature, looking at the association between meteorological variables and attempted and completed suicide.Criteria-based, systematic literature search according to the PRISMA criteria. Peer-reviewed original research studies were included without time limits.A total of 99 studies were included and grouped according to the research analysis based on daily, weekly, monthly and annual data. The majority of the studies reported a statistical association with at least one meteorological variable. The most consistent positive correlation was shown between temperature and suicidal behavior. However, the results are not conclusive and in part contradictory. The reported studies differed distinctively in terms of study design. Meteorological parameters may be associated with suicidal behavior. Future research in this area is needed to provide further clarity. Despite existing knowledge gaps, the current findings may have implications for suicide prevention plans.

Cet article, qui a ete elabore en collaboration avec la Societe Suisse de Psychiatrie et Psychotherapie, est une mise a jour des recommandations therapeutiques de 2011 et 2015.

Data from the deep-sea mooring Kiel 276 (33 ∘ N, 22 ∘ W), 5300 m water depth in the northeast Atlantic, was used to investigate the temporal variability of temperature and currents below the main thermocline (1000 m, 1600 m, 3000 m, 5000 m) in the 30-year period (between 1980 and 2009). Daily averages were the basis to assess the temperature and currents changes, as well as kinetic energy, from annual to decadal and long-term scales. Below the main thermocline, no seasonal signal was identified for both, temperature and currents, during the 30 years. The record-length linear temperature trends at 1000 m and 1600 m are 0.03 ± 0.01 °C year−1 and 0.02 ± 0.02 °C year−1, respectively. The mean currents also intensified within the decades in the entire water column, and as a consequence, the mean kinetic energy increased. The fluctuating kinetic energy increased on a decadal scale only at 1000 m, as a possible consequence of the increase in the strength of Mediterranean Water lenses (MEDDIES) that crossed the mooring site. During the period 2001–2009, six MEDDIES crossed the Kiel 276 site, in addition to the 10 MEDDIES identified earlier during the previous 20 years, between 1980 and 2000 (Siedler et al., 2005). The integral time scales are of the same order in all depths (between 30 to 40 days), indicating that events occur on similar time scales, with mesoscale signals dominating and being present within the entire water column.

Background Psychomotor disturbances are a main clinical feature of major depressive disorder (MDD) but little is known about their EEG signature. One of the most replicated EEG findings in MDD is resting frontal asymmetry in the alpha band (FAA), which is thought to be a correlate of withdrawal behavior and reduced approach motivation. The purpose of this study was to assess psychomotor alterations, alpha band power, FAA and investigate the association between them. Methods 20 MDD patients and 19 healthy subjects were enrolled. Alpha power and FAA scores were calculated from a resting state EEG. Wrist actigraphy was recorded from the non-dominant arm for 24 h and activity level scores (AL) were extrapolated from the wakeful periods. Results MDD patients had a left-lateralized frontal alpha activity and lower AL scores when compared to healthy subjects. A significant correlation was found between mean FAA and AL scores. A negative covariance between power in the lower alpha range and AL scores over the motor cortex bilaterally was detected. Limitations Relatively small sample size. Patients were pharmacologically treated with antidepressants. Conclusions This study replicates the finding of left-lateralized FAA and lower AL scores in MDD patients, and establishes the first evidence of significant correlations between alpha power, FAA scores and measures of motor activity, which may be interpreted as an expression of impaired motivational drive in MDD.

Dans cette version courte, la Societe Suisse de Psychiatrie et de Psychotherapie presente des elements centraux des recommandations therapeutiques a l’intention des medecins de toutes les specialites.

We aimed to assess potential gray matter (GM) alterations for aggressive patterns of behavior in a sample of in- and outpatients with schizophrenia spectrum disorders. Eighty-four patients previously participating in brain volumetric studies were included. Aggression was assessed using the Modified Overt Aggression Scales (MOAS) based upon review of clinical records of the hospital register. Multiple regression analyses for total MOAS and each MOAS subscale separately were conducted correcting for age, sex, history of addiction, chlorpromazine equivalents, illness duration, and total intracranial volume. Significant effects were reported in two cases; the total MOAS scores and MOAS verbal aggression scores were associated with GM volume in left inferior frontal gyrus. From the demographic/clinical characteristics, only the number of episodes correlated with the subscales and the total MOAS scores. Our results highlight the role of GM volume in left inferior frontal gyri in patients with history of aggression. This evidence ties in well with previous data reporting involvement of these regions in response control and semantic networks.

Key Points Question Is the Attempted Suicide Short Intervention Program, a brief novel therapy for individuals who attempt suicide, cost-effective compared with a suicide risk assessment? Findings In this economic evaluation conducted alongside a randomized clinical trial that included 120 Swiss adults, the intervention group had significantly lower levels of suicide reattempts compared with the control group at lower health care costs, with a 96% chance of being less costly and more effective in a sensitivity analysis. Meaning In the context of the Swiss health care system, the Attempted Suicide Short Intervention Program was found to be cost saving as a follow-up treatment for attempted suicide., This secondary analysis of the ASSIP randomized clinical trial compares the cost-effectiveness of a brief novel therapy vs usual care for preventing repeat suicide attempts among patients in Switzerland who had previously attempted suicide., Importance This is the first cost-effectiveness analysis of a brief therapy, the Attempted Suicide Short Intervention Program (ASSIP), for individuals who attempt suicide. Objective To explore the cost-effectiveness of the ASSIP intervention in the context of the Swiss health care system. Design, Setting, and Participants In this economic evaluation, the cost-effectiveness analysis was performed from a health care perspective between January 2017 and April 2018 using data from a randomized clinical trial conducted between June 2009 and December 2014. Participants were individuals who had attempted suicide and were receiving treatment at a psychiatric university hospital in Switzerland that provides inpatient and outpatient services for suicide attempters referred from an emergency department of a general hospital. Interventions The intervention group received 3 manual-based therapy sessions followed by regular personalized letters over 24 months. The control group was offered a single suicide risk assessment. Main Outcomes and Measures The main economic analysis explored cost per suicide attempt avoided expressed in 2015 Swiss francs (CHF). Cost-effectiveness planes were plotted and cost-effectiveness acceptability curves calculated. Results One hundred twenty participants (mean [SD] age, 37.8 [14.4] years; 66 [55%] women and 54 [45%] men) were assigned to an intervention group or a control group, each with 60 participants. At 24 months of follow-up, 5 suicide attempts were reported in the ASSIP group among 59 participants with follow-up data available, and 41 were reported in the control group among 53 participants with follow-up data available. The ASSIP group had higher intervention costs, with CHF 1323 vs CHF 441 for the control group. At 24 months of follow-up, psychiatric hospital costs were lower in the ASSIP group than in the control group, although this difference was not significant (mean [SD], CHF 20 559 [38 676] vs CHF 45 488 [73 306]; mean difference, CHF −16 081; 95% CI, CHF −34 717 to 1536; P = .11). General hospital costs were significantly lower for the ASSIP group. Total health care costs were also lower, but the difference was not significant (mean [SD], CHF 21 302 [38 819] vs 41 287 [74 310]; difference, CHF −12 604; 95% CI, CHF −29 837 to 625; P = .14). In a base-case analysis, ASSIP was dominant, with significantly fewer reattempts at lower overall cost. The intervention had a 96% chance of being less costly and more effective. A sensitivity analysis showed a 96% and 95% chance of ASSIP being more effective and less costly at willingness-to-pay levels of CHF 0 and CHF 30 000, respectively. Conclusions and Relevance The ASSIP intervention is a cost-saving treatment for individuals who attempt suicide. The findings support the use of ASSIP as a treatment for suicide attempters. Further studies are needed to determine cost-effectiveness in other contexts. Trial Registration ClinicalTrials.gov Identifier: NCT02505373.

Background White matter microstructure alterations of limbic and reward pathways have been reported repeatedly for depressive episodes in major depressive disorder (MDD) and bipolar disorder (BD). However, findings during remission are equivocal. It was the aim of this study to investigate if white matter microstructure changes during the time course of clinical remission. Methods Fifteen depressed patients (11 MDD, 4 BD) underwent diffusion-weighted MRI both during depression, and during remission following successful antidepressive treatment (average time interval between scans=6 months). Fractional anisotropy (FA) was sampled along reconstructions of the supero-lateral medial forebrain bundle (slMFB), the cingulum bundle (CB), the uncinate fasciculus (UF), the parahippocampal cingulum (PHC) and the fornix. Repeated measures ANCOVAs controlling for the effect of age were calculated for each tract. Results There was a significant main effect of time (inter-scan interval) for mean-FA for the right CB and for the left PHC. For both pathways there was a significant time×age interaction. In the right CB, FA increased in younger patients, while FA decreased in older patients. In the left PHC, a reverse pattern was seen. FA changes in the right CB correlated positively with symptom reductions. Mean-FA of UF, slMFB and fornix did not change between the two time points. Limitations All patients were medicated, sample size, and lack of control group. Conclusions Right CB and left PHC undergo age-dependent plastic changes during the course of remission and may serve as a state marker in depression. UF, slMFB and FO microstructure remains stable.

Sharp neck injuries in suicidal intention often present as serious emergency situations with the need for an immediate diagnosis and treatment. We report our study of the clinical evolution of this emergency condition. This study investigates the cases of sharp neck injuries in suicidal intention treated at our institution between 2000 and 2010. Patient records were collected in a retrospectively reviewed and analyzed database. The current literature was compared to our findings. We found 36 cases (10 female and 26 male). The neck injuries were superficial and profound in 16 and 20 patients, respectively. Twenty-two patients were seen by the Head and Neck surgeon. A surgical neck exploration was necessary in 19 cases. Tracheal, laryngeal, pharyngeal and vascular injuries were found in one, five, three and three cases, respectively. The hospital stay ranged from 1 to 47 days. All the patients underwent emergency psychiatric assessment and were subsequently referred for psychiatric treatment. One patient died in the emergency room from an additional arterial injury to the wrist. Sharp neck injuries in suicidal intention treated with an interdisciplinary medical, surgical and psychiatric emergency assessment and treatment have low mortality and morbidity.

The reward system in schizophrenia has been linked to the emergence of delusions on the one hand and to negative symptoms such as affective flattening on the other hand. Previous Diffusion Tensor Imaging (DTI) studies reported white matter microstructure alterations of regions related to the reward system. The present study aimed at extending these findings by specifically investigating connection pathways of the reward system in schizophrenia. Therefore 24 patients with schizophrenia and 22 healthy controls matched for age and gender underwent DTI scans. Using a probabilistic fiber tracking approach we bilaterally extracted pathways connecting the ventral tegmental area (VTA) with the nucleus accumbens (NAcc) the medial and lateral orbitofrontal cortices (mOFC lOFC) the dorsolateral prefrontal cortex (dlPFC) and the amygdala; as well as pathways connecting NAcc with mOFC lOFC dlPFC and amygdala resulting in a total of 18 connections. Probability indices forming part of a bundle of interest (PIBI) were compared between groups using independent t tests. In 6 connection pathways PIBI values were increased in schizophrenia. In 3 of these pathways the spatial extension of connection pathways was decreased. In schizophrenia patients there was a negative correlation of PIBI values and PANSS negative scores in the left VTA amygdala and in the left NAcc mOFC connection. A sum score of delusions and hallucinations correlated positively with PIBI values of the left amygdala NAcc connection. Structural organization of specific segments of white matter pathways of the reward system in schizophrenia may contribute to the emergence of delusions and negative symptoms in schizophrenia.

Introduction Substantial heterogeneity remains across studies investigating changes in gray matter in schizophrenia. Differences in methodology, heterogeneous symptom patterns and symptom trajectories may contribute to inconsistent findings. To address this problem, we recently proposed to group patients by symptom dimensions, which map on the language, the limbic and the motor systems. The aim of the present study was to investigate whether patients with prevalent symptoms of emotional dysregulation would show structural neuronal abnormalities in the limbic system. Method 43 right-handed medicated patients with schizophrenia were assessed with the Bern Psychopathology Scale (BPS). The patients and a control group of 34 healthy individuals underwent structural imaging at a 3T MRI scanner. Whole brain voxel-based morphometry (VBM) was compared between patient subgroups with different severity of emotional dysregulation. Group comparisons (comparison between patients with severe emotional dysregulation, patients with mild emotional dysregulation, patients with no emotional dysregulation and healthy controls) were performed using a one way ANOVA and ANCOVA respectively. Results Patients with severe emotional dysregulation had significantly decreased gray matter density in a large cluster including the right ventral striatum and the head of the caudate compared to patients without emotional dysregulation. Comparing patients with severe emotional dysregulation and healthy controls, several clusters of significant decreased GM density were detected in patients, including the right ventral striatum, head of the caudate, left hippocampus, bilateral thalamus, dorsolateral prefrontal and orbitofrontal cortex. The significant effect in the ventral striatum was lost when patients with and without emotional dysregulation were pooled and compared with controls. Discussion Decreased gray matter density in a large cluster including the right ventral striatum was associated with severe symptoms of emotional dysregulation in patients with schizophrenia. The ventral striatum is an important part of the limbic system, and was indicated to be involved in the generation of incentive salience and psychotic symptoms. Only patients with severe emotional dysregulation had decreased gray matter in several brain structures associated with emotion and reward processing compared to healthy controls. The results support the hypothesis that grouping patients according to specific clinical symptoms matched to the limbic system allows identifying patient subgroups with structural abnormalities in the limbic network., Highlights • We examined whole brain VBM in schizophrenia patients and healthy controls. • We compared patients with different severity of emotional dysregulation (ED). • Symptoms of ED were associated with GM density in the ventral striatum. • Grouping patients according to symptoms identified specific GM abnormalities.

Background The medial forebrain bundle (MFB) is a key structure of the reward system and connects the ventral tegmental area (VTA) with the nucleus accumbens (NAcc), the medial and lateral orbitofrontal cortex (mOFC, lOFC) and the dorsolateral prefrontal cortex (dlPFC). Previous diffusion tensor imaging (DTI) studies in major depressive disorder point to white matter alterations of regions which may be incorporated the MFB. Therefore, it was the aim of our study to probe white matter integrity of the MFB using a DTI-based probabilistic fibre tracking approach. Methods 22 patients with major depressive disorder (MDD) (12 melancholic-MDD patients, 10 non-melancholic-MDD patients) and 21 healthy controls underwent DTI scans. We used a bilateral probabilistic fibre tracking approach to extract pathways between the VTA and NACC, mOFC, lOFC, dlPFC respectively. Mean fractional anisotropy (FA) values were used to compare structural connectivity between groups. Results Mean-FA did not differ between healthy controls and all MDD patients. Compared to healthy controls melancholic MDD-patients had reduced mean-FA in right VTA-lOFC and VTA-dlPFC connections. Furthermore, melancholic-MDD patients had lower mean-FA than non-melancholic MDD-patients in the right VTA-lOFC connection. Mean-FA of these pathways correlated negatively with depression scale rating scores. Limitations Due to the small sample size and heterogeneous age group comparisons between melancholic and non-melancholic MDD-patients should be regarded as preliminary. Conclusions Our results suggest that the melancholic subtype of MDD is characterized by white matter microstructure alterations of the MFB. White matter microstructure is associated with both depression severity and anhedonia.

Frontal alpha band asymmetry (FAA) is a marker of altered reward processing in major depressive disorder (MDD), associated with reduced approach behavior and withdrawal. However, its association with brain metabolism remains unclear. The aim of this study is to investigate FAA and its correlation with resting – state cerebral blood flow (rCBF). We hypothesized an association of FAA with regional rCBF in brain regions relevant for reward processing and motivated behavior, such as the striatum. We enrolled 20 patients and 19 healthy subjects. FAA scores and rCBF were quantified with the use of EEG and arterial spin labeling. Correlations of the two were evaluated, as well as the association with FAA and psychometric assessments of motivated behavior and anhedonia. Patients showed a left – lateralized pattern of frontal alpha activity and a correlation of FAA lateralization with subscores of Hamilton Depression Rating Scale linked to motivated behavior. An association of rCBF and FAA scores was found in clusters in the dorsolateral prefrontal cortex bilaterally (patients) and in the left medial frontal gyrus, in the right caudate head and in the right inferior parietal lobule (whole group). No correlations were found in healthy controls. Higher inhibitory right – lateralized alpha power was associated with lower rCBF values in prefrontal and striatal regions, predominantly in the right hemisphere, which are involved in the processing of motivated behavior and reward. Inhibitory brain activity in the reward system may contribute to some of the motivational problems observed in MDD.

Highlights: • Unique data set of daily temperature and current measurements over almost 30 years. • Cooling of the thermocline in the 1980s and extensive warming in the 2000s. • Currents indicate northward displacement of N-Atlantic subtropical Gyre in 1990s. • Influence of NAO and ENSO on current regime even in 500 m water depth. Data from almost thirty years of time series observations from a deep-sea mooring Kiel276 (33°N, 22°W), which was operated in the northeast Atlantic Ocean between 1980 and 2009, are studied to reveal information on the long term changes in the upper thermocline. This includes daily records of temperature and currents at two depths (240 m and 500 m). Until 1988, our analysis shows decreasing temperature in the entire thermocline followed by a slight increase at both depths; from 2000 on, extensive warming began at the shallower depth (240 m) and eight years later at the deeper (500 m) level. A northward displacement of the North Atlantic Subtropical Gyre is indicated by both current measurements and calculated kinetic energy between 1991 and 1998 resulting in an altered current regime in terms of absolute velocity and current directions in the last ten years compared to the first twenty years. Coherences of the currents with large scale climatic patterns such as North Atlantic Oscillation and El Nino/ Southern Oscillation evidence the atmospheric impact even at 500 m water depth.

OBJECTIVE Psychomotor abnormalities characterize both unipolar (UP) depression and bipolar (BP) depression. We aimed to assess their neurobiological correlates in terms of motor activity (AL) and resting-state cerebral blood flow (rCBF) and investigate their association in BP, UP, and healthy controls (HC). METHOD We enrolled 42 depressed patients (22 BP, 20 UP) and 19 HC matched for age, gender, education, income. AL and rCBF were objectively assessed with the use of wrist actigraphy and arterial spin labeling. Group differences and the association of AL and rCBF were computed. RESULTS Activity level was significantly reduced in patients, but no difference was found between BP and UP. Increased perfusion was found in BP compared with UP and HC, in multiple brain areas. We found positive correlations of rCBF and AL in BP and UP, in different parts of the insula and frontal regions. Only BP showed a cluster in the left precentral gyrus. In HC, only inverse correlations of AL and rCBF were found. CONCLUSION The differences in rCBF and in the localization of the clusters of positive AL/rCBF correlations between BP and UP suggest that different neural impairments may underlie motor symptoms in the two disorders, but finally converge in phenotypically similar manifestations.

Background: Switzerland is a traditional immigration country with immigrants from both neighbouring, and less developed countries. Since the early 1990s, the migration rate has continuously increased and in 2013 almost a quarter of Swiss residents had an immigration background. Immigrants in Switzerland had fewer psychiatric hospitalisations, but more emergency and compulsory admissions than the local population. Therefore it is important to study the characteristics of the immigrant population presenting at the emergency department for mental health problems. Methods: Our retrospective data analysis included adult patients (age ≥ 16 years) admitted to our emergency department who consulted a psychiatrist, between 1st of January 2007 and 30th of October 2012. Results: Clinical data from a total of 1115 patients were available for analysis. Of these, 58.6% (n=654) were male and 41.4% (n=461) female. The mean age was 36.3 years, with a range of 16–85 years. The most common reason for psychiatric presentation to the emergency department was psychosis (n=227, 20.3%), followed by social problems with 18.2 % (n=203), auto-aggression with 16.4% (n=193) and 16.2% (n=181) suffering from depression. Conclusions: Translation services are very important. Therapy adherence programs for psychosis and autoaggression prevention programs are especially important for immigrants.

Altered frontal white matter integrity has been reported in major depression. Still, the behavioral correlates of these alterations are not established. In healthy subjects, motor activity correlated with white matter integrity in the motor system. To explore the relation of white matter integrity and motor activity in major depressive disorder, we investigated 21 medicated patients with major depressive disorder and 21 matched controls using diffusion tensor imaging and wrist actigraphy at the same day. Patients had lower activity levels (AL) compared with controls. Fractional anisotropy (FA) differed between groups in frontal white matter regions and the posterior cingulum. AL was linearly associated with white matter integrity in two clusters within the motor system. Controls had an exclusive positive association of FA and AL in white matter underneath the right dorsal premotor cortex. Only patients had a positive association within the posterior cingulum. Furthermore, patients had negative associations of FA and AL underneath the left primary motor cortex and within the left parahippocampal gyrus white matter. These differences in the associations between structure and behavior may contribute to well-known impaired motor planning or gait disturbances in major depressive disorder. Therefore, signs of psychomotor slowing in major depressive disorder may be linked to changes of the white matter integrity of the motor system.

Despite the use of actigraphy in depression research, the association of depression ratings and quantitative motor activity remains controversial. In addition, the impact of recurring episodes on motor activity is uncertain. In 76 medicated inpatients with major depression (27 with a first episode, 49 with recurrent episodes), continuous wrist actigraphy for 24h and scores on the Hamilton Depression Rating Scale (HAMD) were obtained. In addition, 10 subjects of the sample wore the actigraph over a period of 5 days, in order to assess the reliability of a 1-day measurement. Activity levels were stable over 5 consecutive days. Actigraphic parameters did not differ between patients with a first or a recurrent episode, and quantitative motor activity failed to correlate with the HAMD total score. However, of the motor-related single items of the HAMD, the item activities was associated with motor activity parameters, while the items agitation and retardation were not. Actigraphy is consistent with clinical observation for the item activities. Expert raters may not correctly rate the motor aspects of retardation and agitation in major depression.

We aimed to investigate whether aberrant motor behavior in schizophrenia was associated with structural alterations in the motor system. Whole brain voxel based morphometry of patients with different severity of motor symptoms identified altered gray matter volume in the supplementary motor area (SMA), a key region of the motor system.

In this study, the recently developed gradient-based optimisation workflow for the automated development of molecular models is for the first time applied to the parameterisation of force fields for molecular dynamics simulations. As a proof-of-concept, two small molecules (benzene and phosgene) are considered. In order to optimise the underlying intermolecular force field (described by the (12,6)-Lennard-Jones and the Coulomb potential), the energetic and diameter parameters e and σ are fitted to experimental physical properties by gradient-based numerical optimisation techniques. Thereby, a quadratic loss function between experimental and simulated target properties is minimised with respect to the force field parameters. In this proof-of-concept, the considered physical target properties are chosen to be diverse: density, enthalpy of vapourisation and self-diffusion coefficient are optimised simultaneously at different temperatures. We found that in both cases, the optimisation could be successfully co...

To investigate heat transport across a biological membrane, we performed a series of reverse nonequilibrium molecular dynamics (RNEMD) simulations on a model dipalmitoylphosphatidylcholine (DPPC) bilayer system at the atomistic level. In a detailed analysis of the initially irritating results, we show how and to which extent the RNEMD method (in the special case of an ordered, heterogeneous system, like a bilayer in water) is influenced by simulation conditions. We prove that the interplay between the description of the long range forces and the nonequilibrium algorithm can lead to significant changes in the apparent local thermal conductivity profile across the membrane. As this is the first case reported where the otherwise robust RNEMD results are not directly interpretable, we discuss not only the reasons but also several concepts to handle this effect. Note that this is not a flaw of the RNEMD method but of the simulation framework it is performed in. Therefore, the considerations apply to other equilibrium and nonequilibrium molecular dynamics simulations of the thermal conductivities, too, and care must be taken when heterogeneous systems or interfaces appear in simulations. The complete understanding of the directly obtained results finally allows us to describe the heat flow across the membrane qualitatively. On this basis, we show that the tail–tail interface of the bilayer is the most hindering region for the heat flow, and thus, dominates the overall thermal conductivity of the membrane. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2010

Formal thought disorder (FTD) is one of the main symptoms of schizophrenia. To date there are no whole brain volumetric studies investigating gray matter (GM) differences specifically associated with FTD. Here, we studied 20 right-handed schizophrenia patients that differed in the severity of formal thought disorder and 20 matched healthy controls, using voxel-based morphometry (VBM). The severity of FTD was measured with the Scale for the Assessment of Thought, Language, and Communication. The severity was negatively correlated with the GM volume of the left superior temporal sulcus, the left temporal pole, the right middle orbital gyrus and the right cuneus/lingual gyrus. Structural abnormalities specific for FTD were found to be unrelated to GM differences associated with schizophrenia in general. The specific GM abnormalities within the left temporal lobe may help to explain language disturbances included in FTD.

Face processing is crucial to social interaction, but is impaired in schizophrenia patients, who experience delays in face recognition, difficulties identifying others, and misperceptions of affective content. The right fusiform face area plays an important role in the early stages of human face processing and thus may be affected in schizophrenia. The aim of the study was therefore to investigate whether face processing deficits are related to dysfunctions of the right fusiform face area in schizophrenia patients compared with controls. In a rapid, event-related functional magnetic resonance imaging (fMRI) design, we investigated the encoding of new faces, as well as the recognition of newly learned, famous, and unfamiliar faces, in 13 schizophrenia patients and 21 healthy controls. We applied region of interest analysis to each individual's right fusiform face area and tested for group differences. Controls displayed higher blood oxygenation level dependent (BOLD) activation during the memorization of faces that were later successfully recognized. In schizophrenia patients, this effect was not observed. During the recognition task, schizophrenia patients exhibited lower BOLD responses, less accuracy, and longer reaction times to famous and unfamiliar faces. Our results support the hypothesis that impaired face processing in schizophrenia is related to early-stage deficits during the encoding and recognition of faces.

The need for predicting physical compound properties supplementing experimental data is considerable. Nowadays a wide range of classical simulation techniques is available for computing a multitude of such properties with acceptable effort. We here give a field report about our approach, which was to fit an initial model to a single point in the phase diagram. By way of accessing commonly available experimental values we developed a compound-specific force field via simplex optimization. For predicting the desired properties of the novel model we did engage classical equilibrium as well as reverse non-equilibrium molecular dynamics in combination with Monte Carlo methods and report here the performance of these methods in detail for the example compound ethylene oxide. We find that the new model describes the experimentally observed behavior of the test compound ethylene oxide (EO) very well in the molecular dynamics section. However, when applying the simplex optimized model to the Monte Carlo section, the limits of transferability become apparent.

La Societe Suisse de Psychiatrie et Psychotherapie a charge la Societe Suisse des Troubles Bipolaires d’elaborer des recommandations therapeutiques relatives aux troubles bipolaires. Depuis la publication initiale en 2011, les criteres diagnostiques des troubles bipolaires ont ete modifies et de nouvelles etudes et metaanalyses pertinentes ainsi que des revisions de deux recomman­dations therapeutiques importantes relatives aux troubles bipolaires ont ete publiees.

Schizophrenia is associated with heterogeneous course of positive and negative symptoms. In addition, reduced motor activity as measured by wrist actigraphy has been reported. However, longitudinal studies of spontaneous motor activity are missing. We aimed to explore whether activity levels were stable within and between psychotic episodes. Furthermore, we investigated the association with the course of negative symptoms. In 45 medicated patients, we investigated motor behavior within a psychotic episode. In addition, we followed 18 medicated patients across 2 episodes. Wrist actigraphy and psychopathological ratings were applied. Within an episode symptoms changed but activity levels did not vary systematically. Activity at baseline predicted the course of negative symptoms. Between two episodes activity recordings were much more stable. Again, activity at the index episode predicted the outcome of negative symptoms. In sum, spontaneous motor activity shares trait and state characteristics, the latter are associated with negative symptom course. Actigraphy may therefore become an important ambulatory instrument to monitor negative symptoms and treatment outcome in schizophrenia.

In the western equatorial Pacific the low-salinity core of Antarctic Intermediate Water (AAIW) is found at about 800 m depth between potential density levels σθ = 27.2 and 27.3. The pathways of AAIW and the degradation of its core are studied, from the Bismarck Sea to the Caroline Basins and into the zonal equatorial current system. Both historical and new observational data, and results from numerical circulation model runs are used. The observations include hydrographic stations from German and Japanese research vessels, and Eulerian and Lagrangian current measurements. The model is the JAMSTEC high-resolution numerical model based on the Modular Ocean Model (MOM 2). The general agreement between results from the observations and from the model enables us to diagnose properties and to provide new information on the AAIW. The analysis confirms the paramount influence of topography on the spreading of the AAIW tongue north of New Guinea. Two cores of AAIW are found in the eastern Bismarck Sea. One core originates from Vitiaz Strait and one from St. George’s Channel, probably arriving on a cyclonic pathway. They merge in the western Bismarck Sea without much change in their total salt content, and the uniform core then increases considerably in salt content when subjected to mixing in the Caroline Basins. Hydrographic and moored current observations as well as model results show a distinct annual signal in salinity and velocity in the AAIW core off New Guinea. It appears to be related to the monsoonal change that is typically found in the near-surface waters in the region. Lagrangian data are used to investigate the structure of the deep New Guinea Coastal Undercurrent, the related cross-equatorial flow and eddy-structure, and the embedment in the zonal equatorial current system. Results from 17 neutrally buoyant RAFOS floats, ballasted to drift in the AAIW core layer, are compared with a numerical tracking experiment. In the model 73 particles are released at five-day intervals from Station J (2.5°N, 142°E), simulating currents at a moored time series station north of New Guinea. Observed and model track patterns are fairly consistent in space and season. Floats cross the equator preferably north of Cenderawasih Bay, with a maximum range in eddy-motion in this region north of New Guinea. The northward route at 135°E is also reflected in a low-salinity tongue reaching up to 3°N. At that longitude the floats seem to ignore the zonally aligned equatorial undercurrents. Farther to the east (139 145°E), however, the float observations are consistent with low-latitude bands of intermediate currents.

Results of particle flux studies using sediment traps in the northeast Atlantic Ocean at 33oN, 22oW, a time-series station (L1/K276) operated within the German contribution to the international Joint Global Ocean Flux Study (JGOFS) between summer 1993 and summer 2001, are presented. The particle flux at 2000 m depth is highly seasonal with only one main peak in February and March and is characterized by strong interannual variability. The comparison of the particle flux time series with the measurements of chlorophyll and phaeopigments in the sediment trap material, and chlorophyll-a concentrations at surface from SeaWiFS together with the similarity of the pattern observed in the alkenone flux, particulate organic carbon (POC) and calcium carbonate (CaCO3) leads to the conclusion that the particle flux at this position is fast and directly coupled to the phytoplankton development and decay in the overlying euphotic zone. SeaWiFS chlorophyll-a data (1997–2001) and characteristics of the upper water column (mixed layer depth, depth of nitracline, primary production) as predicted by an eddy-permitting model of the North Atlantic coupled with a simple nitrate–phytoplankton–zooplankton–detritus (NPZD) pelagic-ecosystem model are used to understand the observed interannual differences in particle flux at 2000 m. Our results suggest that the interannual differences in the observed particle flux are a direct consequence of the variability of phytoplankton biomass and primary production in the euphotic zone in this region.