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Encoding deficit during face processing within the right fusiform face area in schizophrenia
- Source :
- Psychiatry Research: Neuroimaging. 172:184-191
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- Face processing is crucial to social interaction, but is impaired in schizophrenia patients, who experience delays in face recognition, difficulties identifying others, and misperceptions of affective content. The right fusiform face area plays an important role in the early stages of human face processing and thus may be affected in schizophrenia. The aim of the study was therefore to investigate whether face processing deficits are related to dysfunctions of the right fusiform face area in schizophrenia patients compared with controls. In a rapid, event-related functional magnetic resonance imaging (fMRI) design, we investigated the encoding of new faces, as well as the recognition of newly learned, famous, and unfamiliar faces, in 13 schizophrenia patients and 21 healthy controls. We applied region of interest analysis to each individual's right fusiform face area and tested for group differences. Controls displayed higher blood oxygenation level dependent (BOLD) activation during the memorization of faces that were later successfully recognized. In schizophrenia patients, this effect was not observed. During the recognition task, schizophrenia patients exhibited lower BOLD responses, less accuracy, and longer reaction times to famous and unfamiliar faces. Our results support the hypothesis that impaired face processing in schizophrenia is related to early-stage deficits during the encoding and recognition of faces.
- Subjects :
- Adult
Male
Psychosis
medicine.medical_specialty
Neuroscience (miscellaneous)
Neuropsychological Tests
Audiology
behavioral disciplines and activities
Functional Laterality
Young Adult
Memory
Face perception
Image Processing, Computer-Assisted
medicine
Humans
Radiology, Nuclear Medicine and imaging
Analysis of Variance
Brain Mapping
Facial expression
Fusiform gyrus
medicine.diagnostic_test
Brain
Recognition, Psychology
Cognition
Fusiform face area
medicine.disease
Magnetic Resonance Imaging
Facial Expression
Functional imaging
Psychiatry and Mental health
Pattern Recognition, Visual
Social Perception
Face
Schizophrenia
Female
Schizophrenic Psychology
Cognition Disorders
Functional magnetic resonance imaging
Psychology
Neuroscience
Photic Stimulation
psychological phenomena and processes
Subjects
Details
- ISSN :
- 09254927
- Volume :
- 172
- Database :
- OpenAIRE
- Journal :
- Psychiatry Research: Neuroimaging
- Accession number :
- edsair.doi.dedup.....2b7f2092f52e5cb9b058f572b8fc2aa2