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Inferior frontal gyrus gray matter volume is associated with aggressive behavior in schizophrenia spectrum disorders
- Source :
- Psychiatry research. Neuroimaging. 290
- Publication Year :
- 2018
-
Abstract
- We aimed to assess potential gray matter (GM) alterations for aggressive patterns of behavior in a sample of in- and outpatients with schizophrenia spectrum disorders. Eighty-four patients previously participating in brain volumetric studies were included. Aggression was assessed using the Modified Overt Aggression Scales (MOAS) based upon review of clinical records of the hospital register. Multiple regression analyses for total MOAS and each MOAS subscale separately were conducted correcting for age, sex, history of addiction, chlorpromazine equivalents, illness duration, and total intracranial volume. Significant effects were reported in two cases; the total MOAS scores and MOAS verbal aggression scores were associated with GM volume in left inferior frontal gyrus. From the demographic/clinical characteristics, only the number of episodes correlated with the subscales and the total MOAS scores. Our results highlight the role of GM volume in left inferior frontal gyri in patients with history of aggression. This evidence ties in well with previous data reporting involvement of these regions in response control and semantic networks.
- Subjects :
- Adult
Male
media_common.quotation_subject
Neuroscience (miscellaneous)
Inferior frontal gyrus
Prefrontal Cortex
Gray (unit)
Left inferior frontal gyrus
03 medical and health sciences
Young Adult
0302 clinical medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
In patient
Gray Matter
media_common
Aged
Aggression
business.industry
Verbal Behavior
Addiction
Organ Size
Middle Aged
030227 psychiatry
Psychiatry and Mental health
Schizophrenia
Female
Schizophrenic Psychology
Verbal aggression
medicine.symptom
business
030217 neurology & neurosurgery
Clinical psychology
Schizophrenia spectrum
Subjects
Details
- ISSN :
- 18727506
- Volume :
- 290
- Database :
- OpenAIRE
- Journal :
- Psychiatry research. Neuroimaging
- Accession number :
- edsair.doi.dedup.....53eefc0a7fbeae97e4f086771ce04e63