1. Anionic diketopiperazine induces osteogenic differentiation and supports osteogenesis in a 3D cryogel microenvironment.
- Author
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Panjla A, Qayoom I, Kumar A, and Verma S
- Subjects
- Animals, Cell Proliferation drug effects, Diketopiperazines chemical synthesis, Diketopiperazines toxicity, Mesenchymal Stem Cells drug effects, Mice, Osteoblasts drug effects, Peptides, Cyclic chemical synthesis, Peptides, Cyclic toxicity, Taurine analogs & derivatives, Taurine pharmacology, Taurine toxicity, Tissue Engineering methods, Cell Differentiation drug effects, Cryogels chemistry, Diketopiperazines pharmacology, Osteogenesis drug effects, Peptides, Cyclic pharmacology, Tissue Scaffolds chemistry
- Abstract
Bioactive molecules that enhance or induce osteogenic potential of bone precursor cells have shown vital roles in bone tissue engineering. Herein, we report the design and synthesis of a novel diketopiperazine (DT) that induces osteoblastic differentiation of pre-osteoblasts and bone-marrow-derived stem cells in vitro and enhances the osteogenic potential of cryogel matrix. Such functional diketopiperazines can serve as potential scaffolds for bone healing and regeneration.
- Published
- 2021
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