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Tauromustine is more effective than conventional chemotherapy in the treatment of colonic tumors.
- Source :
-
Diseases of the colon and rectum [Dis Colon Rectum] 1993 Apr; Vol. 36 (4), pp. 394-9. - Publication Year :
- 1993
-
Abstract
- Despite recent advances in chemotherapy, the prognosis of advanced colorectal cancer remains poor. Although the taurine-based nitrosourea tauromustine (TCNU) has demonstrated schedule-dependent synergism with 5-fluorouracil (5-FU) and leucovorin (LV) against a variety of tumors in vitro, its efficacy relative to and in combination with these drugs in vivo remains unknown. To study this, BALB/C mice had C26 tumor implanted subcutaneously five days prior to the following treatment (doses and route of administration being the same in all groups): Group 1--no treatment; Group 2--TCNU (30 mg/kg by gavage); Group 3--LV (100 mg/kg intraperitoneally [IP]) and, one hour later, LV plus 5-FU (100 mg/kg IP); Group 4--LV and, one hour later, LV plus 5-FU and TCNU; and Group 5--TCNU and, on the following day, LV and, one hour later, LV plus 5-FU. All treatments were repeated seven days later. Body weight and tumor weight were measured twice weekly, and survival was noted. Postmortems were performed in all animals, and evidence of primary or secondary tumor was recorded. All surviving animals were sacrificed at 60 days. We found that 1) 87 percent of animals receiving TCNU and 60 percent of animals receiving LV, 5-FU, and TCNU survived to day 60; none of these animals had evidence of tumor when sacrificed; 2) animals in all other groups died by day 34; 3) evidence of metastases was found in five animals in Group 1 and one each in Groups 2 and 5; and 4) administering TCNU 24 hours prior to 5-FU plus LV resulted in death from toxicity in all animals. Thus, while synergism between TCNU and 5-FU plus LV was not seen, the antitumor properties of TCNU are significantly greater than those of conventional chemotherapy.
- Subjects :
- Animals
Anti-Bacterial Agents
Antineoplastic Agents toxicity
Body Weight drug effects
Drug Therapy, Combination
Fluorouracil therapeutic use
Leucovorin therapeutic use
Male
Mice
Mice, Inbred BALB C
Nitrosourea Compounds toxicity
Taurine therapeutic use
Taurine toxicity
Antineoplastic Agents therapeutic use
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Colonic Neoplasms drug therapy
Nitrosourea Compounds therapeutic use
Taurine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0012-3706
- Volume :
- 36
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Diseases of the colon and rectum
- Publication Type :
- Academic Journal
- Accession number :
- 8458268
- Full Text :
- https://doi.org/10.1007/BF02053946