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4. Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics

Author

Takata, Katsuyoshi, Sato, Yasuharu, Nakamura, Naoya, Tokunaka, Mami, Miki, Yukari, Yukie Kikuti, Yara, Igarashi, Kazuhiko, Ito, Etsuro, Harigae, Hideo, Kato, Seiichi, Hayashi, Eiko, Oka, Takashi, Hoshii, Yoshinobu, Tari, Akira, Okada, Hiroyuki, Mohamad, Abd Alkader Lamia, Maeda, Yoshinobu, Tanimoto, Mitsune, Kinoshita, Tomohiro, and Yoshino, Tadashi

Published
2013
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16. Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity: A multicenter, retrospective analysis in Japan

Author

Takata, Katsuyoshi, Okada, Hiroyuki, Ohmiya, Naoki, Nakamura, Shotaro, Kitadai, Yasuhiko, Tari, Akira, Akamatsu, Taiji, Kawai, Hiroki, Tanaka, Shu, Araki, Hiroshi, Yoshida, Takashi, Okumura, Hirokazu, Nishisaki, Hogara, Sagawa, Tamotsu, Watanabe, Norihiko, Arima, Nobuyoshi, Takatsu, Noritaka, Nakamura, Masanao, Yanai, Shunichi, Kaya, Hiroyasu, Morito, Toshiaki, Sato, Yasuharu, Moriwaki, Hisataka, Sakamoto, Choitsu, Niwa, Yasumasa, Goto, Hidemi, Chiba, Tsutomu, Matsumoto, Takayuki, Ennishi, Daisuke, Kinoshita, Tomohiro, and Yoshino, Tadashi

Published
2011
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17. PCR analysis and specific immunohistochemistry revealing a high prevalence of non‐ Helicobacter pylori Helicobacters in Helicobacter pylori ‐negative gastric disease patients in Japan: High susceptibility to an Hp eradication regimen

Author

Nakamura, Masahiko, primary, Øverby, Anders, additional, Michimae, Hirofumi, additional, Matsui, Hidenori, additional, Takahashi, Shinichi, additional, Mabe, Katsuhiro, additional, Shimoyama, Tadashi, additional, Sasaki, Makoto, additional, Terao, Shuici, additional, Kamada, Tomoari, additional, Yanaka, Akinori, additional, Iwamoto, Junichi, additional, Tanabe, Satoshi, additional, Tari, Akira, additional, Nasu, Shinji, additional, Suzuki, Hidekazu, additional, and Yamagata Murayama, Somay, additional

Published
2020
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25. Abstracts of selected papers presented at the 33rd annual meeting of the japanese society of gastroenterology

Author

Fujii, Daigo, Suyama, Masafumi, Sugiyama, Masanori, Atomi, Yutaka, Inui, Kazuo, Nakazawa, Saburo, Nakajima, Kimihiro, Katoh, Hiroyuki, Kaneda, Makoto, Ogura, Yoshifumi, Eto, Toshifumi, Tsunoda, Tsukasa, Uchimura, Masayuki, Narita, Kazuyuki, Sugioka, Atsushi, Tsuzuki, Toshiharu, Kanemitsu, Keiichiro, Tashiro, Seiki, Yoshikawa, Tatsuya, Hanyu, Fujio, Kondo, Satoshi, Nimura, Yuji, Eriguchi, Naofumi, Nakayama, Toshimichi, Mitake, Masahiro, Naitoh, Yasuo, Isawa, T., Okamoto, A., Miyazaki, Hiroshi, Ogata, Yoshirou, Kuno, Nobuyoshi, Kurimoto, Kumiko, Noguchi, Tohru, Makuuchi, Masatoshi, Ikari, Takaaki, Ariyama, Joe, Takao, Sonshin, Shimazu, Hisaaki, Kobari, Masao, Matsuno, Seiki, Tanigawa, K., Mizumoto, R., Nakasako, T., Hanyu, F., Saito, Naoyuki, Hiraoka, Takehisa, Ishikawa, Osamu, Imaoka, Shingi, Miyazaki, Naoyuki, Saitoh, Yoichi, Harada, Akio, Takagi, Hiroshi, Kawai, Y., Yamamoto, S., Nakanishi, Ryo, Beppu, Tomoe, Okushiba, Shunichi, Katoh, Hiroyuki, Sakamoto, Hiroaki, Obara, Katsutoshi, Toba, Masahito, Onda, Masahiko, Azuma, Masayoshi, Kashiwagi, Toru, Sumino, Michihiro, Toyonaga, Atsushi, Hagiwara, Masaru, Sakai, Masahiro, Kokubu, Shigehiro, Shibata, Hisao, Miyoshi, Hirofumi, Orino, Shinya, Yoshida, Tomoharu, Itoh, Tadahiko, Murashima, Naoya, Matsumura, Masahiko, Tsujii, Tadasu, Murayama, Takashi, Tameda, Yukihiko, Matsutani, Shoichi, Ishii, Hiroshi, Mitarai, Yoshinobu, Kobayashi, Michio, Nishida, Hitoshi, Kawada, Taiji, Matsuda, Hiroko, Kawasaki, Tsunehisa, Arakawa, Tetsuo, Kobayashi, Kenzo, Ota, Shinichi, Terano, Akira, Nakamura, Masahiko, Oda, Masaya, Tari, Akira, Yamamoto, Goso, Saito, Eiichi, Matsuo, Yutaka, Mizuno, Motowo, Tomoda, Jun, Asada, Shuji, Takiuchi, Hiroya, Mogi, Mizuhiro, Kitajima, Masaki, Nagano, Kouichi, Sato, Nobuhiro, Naito, Yuji, Yoshikawa, Toshikazu, Asaka, Masahiro, Sato, Yasuo, Iwafuchi, Mitsuya, Watanabe, Hidenobu, Yoshida, Yukio, Kihira, Ken, Kashiwagi, Hideyuki, Aoki, Teruaki, Nishikawa, Masahiro, Suzuki, Takashi, Matsui, Toshiyuki, Iida, Mitsuo, Katoh, H., Munakata, A., Itsuno, Minoru, Makiyama, Kazuya, Hibi, Toshifumi, Kitahora, Tetsuji, Igarashi, Masahiro, Katsumata, Tomoe, Satomi, Masamichi, Yamamura, Makoto, Hirata, Ichiro, Slezak, Premysl, Kubota, Yoshiro, Muto, Tetsuichiro, Morise, Kimitomo, Kusugami, Kazuo, Sugita, Akira, Fukushima, Tsuneo, Okada, Mitsuo, Sakurai, Toshihiro, Iida, Mitsuo, Kawasaki, Atsushi, Hiwatashi, Nobuo, Yamazaki, Hideo, Oriishi, Tetsuharu, Sasaki, Ei, Takazoe, Masakazu, Inoue, Noboru, Funayama, Y., and Matsuno, S.

Published
1993
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26. Evidence that endogenous GRP in rat stomach mediates omeprazole-induced hypergastrinemia

Author

Takehara, Yoshihiko, Sumii, Koji, Tari, Akira, Yoshihara, Masaharu, Haruma, Ken, Kajiyama, Goro, Wu, S. Vincent, and Walsh, John H.

Subjects
Gastrin -- Physiological aspects, Rats -- Physiological aspects, Stomach -- Physiological aspects, Omeprazole -- Physiological aspects, Biological sciences
Abstract

An investigation of gastrin release in a murine model of hypergastrinemia induced by omeprazole, a drug for treating ulcers, has provided evidence to support that endogenous gastrin-releasing peptide (GRP) mediates gastrin secretion. It was shown that during hypergastrinemia, the inhibition of gastrin release activates a signal for the release of GRP, which, in turn, stimulates gastrin secretion.

Published
1996

29. Effect of histamine on rat gastric H+-K+-ATPase alpha-subunit expression

Author

Tari, Akira, Yamamoto, Gohso, Yonei, Yoshikazu, Sumii, Masaharu, Sumii, Koji, Haruma, Ken, Kajiyama, Goro, Wu, Vincent, Sachs, George, and Walsh, John H.

Subjects
Stomach -- Secretions, Histamine receptors -- Physiological aspects, Biological sciences
Abstract

Studies on rat gastric H+-K+-ATPase alpha subunit reveal that H2 receptor activation leads to histamine stimulation of H+-K+-ATPase alpha subunit activity. Famotidine, which enhances gastric pH and serum gastrin, reduces the H2 receptor action. It also reduces the level of H+-K+-ATPase mRNA.

Published
1994

31. Watch-and-wait policyversusrituximab-combined chemotherapy in Japanese patients with intestinal follicular lymphoma

Author

Tari, Akira, primary, Kitadai, Yasuhiko, additional, Mouri, Ritsuo, additional, Takigawa, Hidehiko, additional, Asaoku, Hideki, additional, Mihara, Keiichiro, additional, Takata, Katsuyoshi, additional, Fujihara, Megumu, additional, Yoshino, Tadashi, additional, Koga, Tadashi, additional, Fujimori, Shunji, additional, Tanaka, Shinji, additional, and Chayama, Kazuaki, additional

Published
2018
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33. CD10 down expression in follicular lymphoma correlates with gastrointestinal lesion involving the stomach and large intestine

Author

Ohnishi, Nobuhiko, primary, Takata, Katsuyoshi, additional, Miyata‐Takata, Tomoko, additional, Sato, Yasuharu, additional, Tari, Akira, additional, Gion, Yuka, additional, Noujima‐Harada, Mai, additional, Taniguchi, Kohei, additional, Tabata, Tetsuya, additional, Nagakita, Keina, additional, Omote, Shizuma, additional, Takahata, Hiroyuki, additional, Iwamuro, Masaya, additional, Okada, Hiroyuki, additional, Maeda, Yoshinobu, additional, Yanai, Hiroyuki, additional, and Yoshino, Tadashi, additional

Published
2016
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34. Clinicopathological features of 49 primary gastrointestinal diffuse large B-cell lymphoma cases; comparison with location, cell-of-origin, and frequency of MYD88 L265P

Author

Nagakita, Keina, primary, Takata, Katsuyoshi, additional, Taniguchi, Kohei, additional, Miyata-Takata, Tomoko, additional, Sato, Yasuharu, additional, Tari, Akira, additional, Ohnishi, Nobuhiko, additional, Noujima-Harada, Mai, additional, Omote, Shizuma, additional, Nakamura, Naoya, additional, Iwamuro, Masaya, additional, Maeda, Yoshinobu, additional, Okada, Hiroyuki, additional, Tanimoto, Mitsune, additional, and Yoshino, Tadashi, additional

Published
2016
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37. Watch‐and‐wait policy versus rituximab‐combined chemotherapy in Japanese patients with intestinal follicular lymphoma.

Author

Tari, Akira, Mouri, Ritsuo, Tanaka, Shinji, Kitadai, Yasuhiko, Takigawa, Hidehiko, Chayama, Kazuaki, Asaoku, Hideki, Mihara, Keiichiro, Takata, Katsuyoshi, Yoshino, Tadashi, Fujihara, Megumu, Koga, Tadashi, and Fujimori, Shunji

Subjects
*RITUXIMAB, *LYMPHOMAS, *GASTROINTESTINAL system abnormalities, *CANCER chemotherapy, *DUODENAL diseases
Abstract

Abstract: Background and Aim: Few reports have demonstrated the effectiveness of treatments for intestinal follicular lymphoma (FL) because of the limited number of patients who undergo comprehensive small intestinal examinations. This study compared the efficacy of rituximab‐combined chemotherapy in patients with asymptomatic and low tumor burden (LTB) intestinal FL, according to the criteria of the Groupe d'Etude des Lymphomes Folliculaires, with that of a “watch and wait” (W&W) approach. Methods: The endoscopic examination for entire gastrointestinal tracts was performed in 29 Japanese patients with intestinal FL. These patients had CD21‐positive follicular dendritic cells arranged in a duodenal pattern. In a prospective, two‐center, open‐label trial, this study evaluated the efficacy of rituximab‐combined chemotherapy ([cyclophosphamide, doxorubicin, vincristine, and prednisone] or [cyclophosphamide, vincristine, and prednisone]) and prolonged treatment with rituximab (R‐Chemo+prolongedR) in 14 patients and compared their outcomes with those of 15 patients managed with a W&W approach. Results: Four patients managed with the W&W plan showed worsening macroscopic findings, lesion area enlargement, or clinical stage progression but stayed on this plan because they had LTB and experienced no changes in bowel function. In the R‐Chemo+prolongedR group, all patients achieved complete remission; recurrence occurred in one patient, who was subsequently managed with the W&W plan because of LTB. There were no significant differences in progression‐free survival between the two groups (P = 0.1045). Overall survival was 100% in both groups. Conclusions: The prognoses of patients with asymptomatic intestinal FL and LTB who were managed with a W&W strategy were comparable with those of patients receiving R‐Chemo+prolongedR. [ABSTRACT FROM AUTHOR]

Published
2018
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38. Anti‐<italic>Helicobacter pylori</italic> therapy in localized gastric mucosa‐associated lymphoid tissue lymphoma: A prospective, nationwide, multicenter study in Japan.

Author

Sugizaki, Katsuya, Tari, Akira, Kitadai, Yasuhiko, Oda, Ichiro, Nakamura, Shotaro, Yoshino, Tadashi, and Sugiyama, Toshiro

Subjects
*ANTIBACTERIAL agents, *LYMPHOMAS, *LYMPHOID tissue, *GASTROINTESTINAL mucosa, *SURVIVAL analysis (Biometry), *THERAPEUTICS, TREATMENT of helicobacter pylori infections
Abstract

Abstract: Background: Helicobacter pylori eradication therapy was approved in Japan for the first‐line, standard treatment of H. pylori‐positive gastric mucosa‐associated lymphoid tissue (MALT) lymphoma. Although several retrospective studies or small‐scale single‐center studies have been reported, a prospective, large‐scale, nationwide, multicenter study has not been reported from Japan. Materials and Methods: We conducted a prospective, nationwide, multicenter study to evaluate the clinical efficacy of rabeprazole‐based triple H. pylori eradication therapy for patients with localized gastric MALT lymphoma in practice‐based clinical trial. A total of 108 H. pylori‐positive patients with stage I/II1 gastric MALT lymphoma underwent H. pylori eradication therapy. The primary endpoints were complete remission (CR) rate and the rate of transfer to secondary treatment. The secondary endpoints were CR maintenance duration and overall survival (OS). Results: CR of lymphoma was achieved in 84 of 97 patients (86.6%), during the period 2.0‐44.7 months (median, 5.3 months) after starting H. pylori eradication treatment. CR was maintained in 77 of 81 patients (95.1%) for 0.4‐53.2 months (median, 33.1 months). Secondary treatments (radiotherapy, rituximab, or gastrectomy) for gastric MALT lymphoma were needed in 10 of the 97 patients (10.31%). During follow‐up, OS rate was 96.9% (94/97) and the causes of 3 deaths were not related to lymphoma. Conclusions: Rabeprazole‐based H. pylori eradication therapy demonstrated a high CR rate, long CR maintenance, and a good OS for patients with localized gastric MALT lymphoma in this prospective, practice‐based, multicenter study. [ABSTRACT FROM AUTHOR]

Published
2018
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41. Clinicopathologic Analysis of 6 Lymphomatoid Gastropathy Cases

Author

Takata, Katsuyoshi, primary, Noujima-Harada, Mai, additional, Miyata-Takata, Tomoko, additional, Ichimura, Koichi, additional, Sato, Yasuharu, additional, Miyata, Takafumi, additional, Naruse, Keishi, additional, Iwamoto, Toshiyuki, additional, Tari, Akira, additional, Masunari, Taro, additional, Sonobe, Hiroshi, additional, Okada, Hiroyuki, additional, Iwamuro, Masaya, additional, Mizobuchi, Kohichi, additional, Gion, Yuka, additional, and Yoshino, Tadashi, additional

Published
2015
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42. Helicobacter pylori Infection and Gastroduodenal Disease : a Comparison of Endoscopic Findings, Histology, and Urease Test Data

Author

Haruma, Ken, Okamoto, Shiro, Sumii, Koji, Yoshihara, Masaharu, Tari, Akira, Teshima, Hitosihi, Shimamoto, Takehiro, Takehara, Yoshihiko, Tanaka, Shinji, Yamamoto, Goso, Teixeira, Claudio Rolim, Sumii, Masaharu, Kishimoto, Shinya, Kajiyama, Goro, and Wagner, Siegfried

Subjects
Peptic ulcer, Gastritis, Gastric carcinoma, digestive system diseases, Helicobacter pylori infection
Abstract

To determine the prevalence and significance of Helicobacter pylori (H. pylori) infection, biopsies of the antral mucosa were obtained from 139 patients and 43 asymptomatic volunteers. The specimens were examined by hematoxylin-eosin staining and the urease test. The detection rate of H. pylori by histologic examination was 91.3% in patients with duodenal ulcer, 75.0% in those with combined duodenal and gastric ulcer, 63.6% in those with gastric ulcer, 22.9% in those with gastric carcinoma, 36.4% in those with gastric adenoma, 14.3% in those with gastric hyperplastic polyp, and 51.7% in those with gastritis, and the respective percentages detected by the urease test were 91.3%, 75.0%, 54.5%, 28.6%, 27.3%, 14.3%, and 44.8%. H. pylori was also detected in 10/43 (23.3%) asymptomatic healthy volunteers by histology and the urease test. The prevalence of H. pylori was significantly higher in the patients than in the asymptomatic healthy volunteers (p < 0.05). H. pylori was detected in 62.9% of patients with endoscopic erosive gastritis and in 97.9% of those with histologically proven chronic active gastritis. The urease test was positive in 77/82 patients who were histologically positive for the organism (sensitivity: 93.9%), and it was negative in 98/100 patients who were negative by histology (specificity: 98.0%). Thus, there was over 90% agreement between the urease test and histology. Our investigations showed that H. pylori was closely related to peptic ulcers and antral gastritis, and that the urease test provides a simple, rapid and accurate diagnosis of H. pylori infection.

Published
1992

43. Erratum: Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics

Author

Takata, Katsuyoshi, primary, Sato, Yasuharu, additional, Nakamura, Naoya, additional, Tokunaka, Mami, additional, Miki, Yukari, additional, Kikuti, Yara Yukie, additional, Igarashi, Kazuhiko, additional, Ito, Etsuro, additional, Harigae, Hideo, additional, Kato, Seiichi, additional, Hayashi, Eiko, additional, Oka, Takashi, additional, Hoshii, Yoshinobu, additional, Tari, Akira, additional, Okada, Hiroyuki, additional, Lamia Mohamad, Abd Alkader, additional, Maeda, Yoshinobu, additional, Tanimoto, Mitsune, additional, Kinoshita, Tomohiro, additional, and Yoshino, Tadashi, additional

Published
2013
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44. Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B cell characteristics

Author

Takata, Katsuyoshi, primary, Sato, Yasuharu, additional, Nakamura, Naoya, additional, Tokunaka, Mami, additional, Miki, Yukari, additional, Kikuti, Yara Yukie, additional, Igarashi, Kazuhiko, additional, Ito, Etsuro, additional, Harigae, Hideo, additional, Kato, Seiichi, additional, Hayashi, Eiko, additional, Oka, Takashi, additional, Hoshii, Yoshinobu, additional, Tari, Akira, additional, Okada, Hiroyuki, additional, Mohamado, Abd Alkader Lamia, additional, Maeda, Yoshinobu, additional, Tanimoto, Mitsune, additional, Kinoshita, Tomohiro, additional, and Yoshino, Tadashi, additional

Published
2013
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46. The role of “watch and wait” in intestinal follicular lymphoma in rituximab era.

Author

Tari, Akira, Asaoku, Hideki, Takata, Katsuyoshi, Fujimori, Shunji, Tanaka, Shinji, Fujihara, Megumu, Koga, Tadashi, and Yoshino, Tadashi

Subjects
*LYMPHOMA diagnosis, *MONOCLONAL antibodies, *RITUXIMAB, *PATIENT compliance, *DIGESTIVE system endoscopic surgery
Abstract

Objective: There is no consensus regarding the best treatment for intestinal follicular lymphoma (FL). We used “watch and wait” for patients with intestinal FL with low-tumor-burden (LTB) criteria and without mass formation causing bowel obstruction. We investigated the overall survival (OS) and time to treatment required (TTR).Methods: Thirty-three intestinal FL patients [clinical stage (CS) I:16, II1:0, II2:7, IV:10; median observation period: 45.5 months, range: 13–110 months] were diagnosed via endoscopy. Detailed clinical and pathological examinations were performed, and neoplastic process behavior was monitored.Results: All of the 33 patients were WHO grade 1. FL lesions in the digestive tract were found frequently in the second–fourth portion of the duodenum in 91% of the patients; 87% of those patients had lesions in a broader area including the small intestine. Two patients had an enlargement of the area of the lesions and a worsening of the macroscopic findings. Three patients had CS progression; however, these remained within the indication for “watch and wait.” Two patients with transformation into diffuse large B-cell lymphoma received rituximab and chemotherapy, which led to complete remission. The OS was 100%. The time to treatment required (TTR) was 49 months in one patient and 37 months in one patient.Conclusion: Intestinal FL in CS I–IV with broad infiltration of the digestive tract meeting the criteria for LTB had a remarkably slow course. This study suggests that “watch and wait” is appropriate for the treatment of LTB intestinal FL even in the era of rituximab. [ABSTRACT FROM PUBLISHER]

Published
2016
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47. Long-Term Clinical Outcome of Gastric MALT Lymphoma After Eradication of Helicobacter pylori : A Multicenter Retrospective Follow-up Study of 423 Patients in Japan

Author

Nakamura, Shotaro, primary, Iijima, Katsunori, additional, Ono, Shouko, additional, Tajika, Masahiro, additional, Tari, Akira, additional, Kitadai, Yasuhiko, additional, Matsumoto, Hiroshi, additional, Nagaya, Tadanobu, additional, Kamoshida, Toshiro, additional, Watanabe, Norihiko, additional, Chiba, Toshimi, additional, Matsumoto, Takayuki, additional, Origasa, Hideki, additional, Asaka, Masahiro, additional, and Sugiyama, Toshiro, additional

Published
2011
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