45 results on '"Tang Chuan Wang"'
Search Results
2. Hypothyroidism and related comorbidities on the risks of developing tinnitus
- Author
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Alan Hsu, Yung-an Tsou, Tang-Chuan Wang, Wen-Dien Chang, Cheng-Li Lin, and Richard S. Tyler
- Subjects
Medicine ,Science - Abstract
Abstract This is a retrospective longitudinal study that uses data from the National Health Insurance Research Database (NHIRD) of Taiwan of which hypothyroid patients who received a diagnosis between 2000 and 2010 were selected and followed up until 2011. The primary outcome of this study was the occurrence of tinnitus (ICD-9-CM code 388.3). The relevant comorbidities were selected as potential confounders according to the literature, which included vertigo (ICD-9-CM code 386), insomnia (ICD-9-CM code 780), anxiety (ICD-9-CM code 300.00), and hearing loss (ICD-9-CM code 388–389). The overall incidence of tinnitus was significantly higher in the hypothyroidism cohort than in the non-hypothyroidism cohort (9.49 vs. 6.03 per 1000 person-years), with an adjusted HR of 1.35 (95% CI 1.18–1.54) after adjusting potential confounders. The incidences of tinnitus, as stratified by gender, age, comorbidity, and follow-up time, were all significantly higher in the hypothyroidism cohort than those in the non-hypothyroidism cohort. The incidence of tinnitus significantly increased with age (aHR = 1.01, 95% CI 1.01–1.02). In conclusion, we report the relationship between hypothyroidism and the increased risk for tinnitus. We also found that hypothyroidism patients are at increased risk of developing tinnitus when associated with comorbidities including vertigo, hearing loss, and insomnia.
- Published
- 2022
- Full Text
- View/download PDF
3. Increased Incidence of Tinnitus Following a Hyperthyroidism Diagnosis: A Population-Based Longitudinal Study
- Author
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Tang-Chuan Wang, Chien-Jen Chiu, Pei-Chun Chen, Ta-Yuan Chang, Richard S. Tyler, Eveling Rojas-Roncancio, Claudia Barros Coelho, Patricia C. Mancini, Cheng-Li Lin, Chia-Der Lin, and Ming-Hsui Tsai
- Subjects
hyperthyroidism ,incidence ,risk factors ,tinnitus ,cohort study ,national health insurance research database ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
BackgroundAn association between thyroid disease and tinnitus has been described previously but further longitudinal, population-based studies are limited.ObjectiveTo investigate the incidence of tinnitus in patients with hyperthyroidism in a national sample, and to identify risk level and associated factors for tinnitus in hyperthyroidism patients.DesignRetrospective cohort study. Patient data were collected from the Longitudinal Health Insurance Database (LHID 2000), which includes national claims data of patient expenditures for admissions or ambulatory care from 1996 to 2011.SettingTaiwan hospitals and clinics providing healthcare nationwide.ParticipantsPatients aged 20 years and older with newly diagnosed hyperthyroidism (ICD-9-CM code 242) between 2000-2010 were selected as the study cohort. Hyperthyroidism patient cohort were identified from the LHID2000. Those with tinnitus history (ICD-9-CM code 388.3) before the index date (first hyperthyroidism diagnosis), younger than 20 years, and with incomplete demographic data were excluded. The non-hyperthyroidism cohort included patients with no history of hyperthyroidism and no documented tinnitus.Main Outcomes and MeasuresIncidence of tinnitus was the primary outcome. Baseline demographic factors and comorbidities possibly associated with tinnitus, including age, sex, and comorbidities of hearing loss, vertigo, insomnia and anxiety, were retrieved from the LHID 2000. Patients were followed until end of 2011.ResultsDuring the study period, 780 (4.9%) hyperthyroidism patients and 2007 (3.2%) non-hyperthyroidism controls developed tinnitus. Incidence rate of tinnitus in the hyperthyroidism cohort was significantly higher in hyperthyroidism cohort (7.86 vs. 5.05 per 1000 person-years) than that in non-hyperthyroidism cohort. A higher proportion of patients with hyperthyroidism had comorbid insomnia (45.1% vs. 30.9%) and anxiety (14.0% vs. 5.73%) than those without hyperthyroidism. After adjusting for age, gender and comorbidities (vertigo, insomnia, anxiety, hearing loss), hyperthyroidism patients had 1.38-fold higher risk of tinnitus (95% CI = 1.27-1.50) than those without hyperthyroidism.ConclusionsThis large population-based study suggests patients with diagnosed hyperthyroidism was more prone to develop tinnitus. Our findings suggest evaluation for comorbid vertigo, insomnia, anxiety and/or hearing loss may identify patients who are at high risk of developing tinnitus in patients with hyperthyroidism.
- Published
- 2021
- Full Text
- View/download PDF
4. A comprehensive finite-element human ear model to estimate noise-induced hearing loss associated with occupational noise exposure.
- Author
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You-Cheng Yu, Tang-Chuan Wang, and Tzu-Ching Shih
- Published
- 2022
- Full Text
- View/download PDF
5. Effects of age-related tympanic-membrane material properties on sound transmission in the middle ear in a three-dimensional finite-element model.
- Author
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You-Cheng Yu, Tang-Chuan Wang, and Tzu-Ching Shih
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- 2022
- Full Text
- View/download PDF
6. Effect of Chinese Herbal Medicine Therapy on Overall and Cancer Related Mortality in Patients With Advanced Nasopharyngeal Carcinoma in Taiwan
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Chen-Yu Wang, Tang-Chuan Wang, Wen-Miin Liang, Chien-Hui Hung, Jian-Shiun Chiou, Chao-Jung Chen, Fuu-Jen Tsai, Sheng-Teng Huang, Ta-Yuan Chang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Te-Mao Li, and Ying-Ju Lin
- Subjects
advanced nasopharyngeal carcinoma ,overall mortality ,chinese herbal medicine ,association rule ,network analysis ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Nasopharyngeal carcinoma (NPC) is a head and neck cancer involving epithelial squamous-cell carcinoma of the nasopharynx that mainly occurs in individuals from East and Southeast Asia. We investigated whether Chinese herbal medicine (CHM) as a complementary therapy offers benefits to these patients. We retrospectively evaluated the Taiwan Cancer Registry (Long Form) database for patients with advanced NPC, using or not using CHM, between 2007–2013. Cox proportional-hazard model and Kaplan‒Meier survival analyses were applied for patient survival. CHM-users showed a lower overall and cancer-related mortality risk than non-users. For advanced NPC patients, the overall mortality risk was 0.799-fold for CHM-users, after controlling for age, gender, and Charlson comorbidity index (CCI) score (Cancer stages 3 + 4: adjusted hazard ratio [aHR]: 0.799, 95% confidence interval [CI]: 0.676–0.943, p = 0.008). CHM-users also showed a lower cancer-related mortality risk than non-users (aHR: 0.71, 95% CI: 0.53–0.96, p = 0.0273). Association rule analysis showed that CHM pairs were Ban-Zhi-Lian (BZL; Scutellaria barbata D.Don) and For single herbs, Bai-Hua-She-She-Cao (Herba Hedyotis Diffusae; Scleromitrion diffusum (Willd.) R.J.Wang (syn. Hedyotis diffusa Willd.) and Mai-Men-Dong (MMD; Ophiopogon japonicus (Thunb.) Ker Gawl.), and Gan-Lu-Yin (GLY) and BHSSC. Network analysis revealed that BHSSC was the core CHM, and BZL, GLY, and Xin-Yi-Qing-Fei-Tang (XYQFT) were important CHMs in cluster 1. In cluster 2, ShengDH, MMD, Xuan-Shen (XS; Scrophularia ningpoensis Hensl.), and Gua-Lou-Gen (GLG; Trichosanthes kirilowii Maxim.) were important CHMs. Thus, as a complementary therapy, CHM, and particularly the 8 CHMs identified, are important for the treatment of advanced NPC patients.
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- 2021
- Full Text
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7. Challenging Issues on Paranasal Sinuses
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Tang-Chuan Wang and Tang-Chuan Wang
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- 2019
8. Management of Tinnitus: The Enriching Views of Treatment Options
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Tang-Chuan Wang and Tang-Chuan Wang
- Published
- 2019
9. Noise Induced Hearing Loss and Tinnitus—New Research Developments and Remaining Gaps in Disease Assessment, Treatment, and Prevention
- Author
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Tang-Chuan Wang, Ta-Yuan Chang, Richard Tyler, Ying-Ju Lin, Wen-Miin Liang, Yio-Wha Shau, Wei-Yong Lin, Yi-Wen Chen, Chia-Der Lin, and Ming-Hsui Tsai
- Subjects
central auditory system ,cochlear damage ,deafferentation ,hidden hearing loss ,maladaptive plasticity ,neural plasticity ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Long-term noise exposure often results in noise induced hearing loss (NIHL). Tinnitus, the generation of phantom sounds, can also result from noise exposure, although understanding of its underlying mechanisms are limited. Recent studies, however, are shedding light on the neural processes involved in NIHL and tinnitus, leading to potential new and innovative treatments. This review focuses on the assessment of NIHL, available treatments, and development of new pharmacologic and non-pharmacologic treatments based on recent studies of central auditory plasticity and adaptive changes in hearing. We discuss the mechanisms and maladaptive plasticity of NIHL, neuronal aspects of tinnitus triggers, and mechanisms such as tinnitus-associated neural changes at the cochlear nucleus underlying the generation of tinnitus after noise-induced deafferentation. We include observations from recent studies, including our own studies on associated risks and emerging treatments for tinnitus. Increasing knowledge of neural plasticity and adaptive changes in the central auditory system suggest that NIHL is preventable and transient abnormalities may be reversable, although ongoing research in assessment and early detection of hearing difficulties is still urgently needed. Since no treatment can yet reverse noise-related damage completely, preventative strategies and increased awareness of hearing health are essential.
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- 2020
- Full Text
- View/download PDF
10. TCM as adjunctive therapy improves risks of respiratory hospitalizations in persons with type 2 diabetes: A retrospective cohort study
- Author
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Pei-Chun Lin, Cheng-Chieh Lin, Chia-Ing Li, Tang-Chuan Wang, Yi-Hao Peng, Tung-Ti Chang, Chin-Yi Lin, Tsai-Chung Li, and Ching-Liang Hsieh
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General Medicine - Published
- 2023
11. Quantification of Transient Evoked Otoacoustic Emissions by Sample Entropy to Assess Cochlear Symptoms in Meniere's Disease
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Jui Fang, Yi-Wen Liu, Yi-Wen Chen, Tzu Ching Shih, Chun-Hsu Yao, Chon-Haw Tsai, Richard S. Tyler, Alan Y. Hsu, and Tang-Chuan Wang
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History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
12. Reliability of the Minimum Masking Level as Outcome Variable in Tinnitus Clinical Research
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Carrie Secor, Patricia C. Mancini, Shelley Witt, Eveling Rojas-Roncancio, Christina Stocking, Tang-Chuan Wang, Helena Ji, Richard S. Tyler, and Hyung Jin Jun
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Adult ,Male ,medicine.medical_specialty ,Audiology ,Standard deviation ,Loudness ,Correlation ,Tinnitus ,Young Adult ,03 medical and health sciences ,Speech and Hearing ,symbols.namesake ,0302 clinical medicine ,Outcome variable ,Outcome Assessment, Health Care ,Masking level ,medicine ,Humans ,Speech ,030223 otorhinolaryngology ,Aged ,Mathematics ,Weak relationship ,Reproducibility of Results ,Middle Aged ,Pearson product-moment correlation coefficient ,Acoustic Stimulation ,symbols ,Female ,medicine.symptom ,Noise ,Perceptual Masking ,030217 neurology & neurosurgery - Abstract
Purpose The minimum masking level (MML) is the minimum intensity of a stimulus required to just totally mask the tinnitus. Treatments aimed at reducing the tinnitus itself should attempt to measure the magnitude of the tinnitus. The objective of this study was to evaluate the reliability of the MML. Method Sample consisted of 59 tinnitus patients who reported stable tinnitus. We obtained MML measures on two visits, separated by about 2–3 weeks. We used two noise types: speech-shaped noise and high-frequency emphasis noise. We also investigated the relationship between the MML and tinnitus loudness estimates and the Tinnitus Handicap Questionnaire (THQ). Results There were differences across the different noise types. The within-session standard deviation averaged across subjects varied between 1.3 and 1.8 dB. Across the two sessions, the Pearson correlation coefficients, range was r = .84. There was a weak relationship between the dB SL MML and loudness, and between the MML and the THQ. A moderate correlation ( r = .44) was found between the THQ and loudness estimates. Conclusions We conclude that the dB SL MML can be a reliable estimate of tinnitus magnitude, with expected standard deviations in trained subjects of about 1.5 dB. It appears that the dB SL MML and loudness estimates are not closely related.
- Published
- 2020
13. A comprehensive finite-element human ear model to estimate noise-induced hearing loss associated with occupational noise exposure
- Author
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Tzu-Ching Shih, You-Cheng Yu, and Tang-Chuan Wang
- Subjects
Male ,Adult ,History ,Polymers and Plastics ,Health Informatics ,Industrial and Manufacturing Engineering ,Cochlea ,Computer Science Applications ,Young Adult ,Hearing Loss, Noise-Induced ,Noise, Occupational ,Humans ,Female ,Business and International Management ,Software - Abstract
Noise is a common occupational and environmental hazard; however, little is known about the use of computational tools to quantitively analyze data on basilar membrane (BM) damage in noise-induced hearing loss (NIHL). Here, we established a comprehensive three-dimensional finite-element human ear model to quantify the impact of noise exposure on BM and perilymph fluid.We used auditory risk units (ARUs) to evaluate the BM damage for subjects (3 men and 5 women; mean age, 32.75 ± 8.86 years; age range, 24-44 years). A 90-dB sound pressure level (SPL) was normally applied at the external auditory canal (EAC) entrance to simulate sound transmission from the EAC to the cochlea at frequencies of 0.2-10.0 kHz.The pressure distribution of perilymph fluid is totally different on frequency responses under low and high sound-evoked (0.013-10.0 kHz). The highest ARUs were 18.479% at the distance of 1 mm from the base, and the second-highest to fourth-highest ARUs occurred at distances of 5-7 mm from the base, where their ARUs were 9.749%, 9.176%, and 11.231%. The total of the ARUs reached 81.956% at external frequencies' sounds of 3.2-5.0 kHz. Among these, the 3.8-kHz and 3.6-kHz frequencies yielded the highest and second-highest ARUs of 20.325% and 19.873%, respectively.This study would inform our understanding of NIHL associated with occupational noise exposure. We present a FE modelling and describe how it might provide a unique way to unravel mechanisms that drive NIHL due to loud noises.
- Published
- 2022
14. Hypothyroidism and related comorbidities on the risks of developing tinnitus
- Author
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Alan Hsu, Yung-an Tsou, Tang-Chuan Wang, Wen-Dien Chang, Cheng-Li Lin, and Richard S. Tyler
- Subjects
Multidisciplinary ,Incidence ,Taiwan ,Comorbidity ,Tinnitus ,Hypothyroidism ,Risk Factors ,Sleep Initiation and Maintenance Disorders ,otorhinolaryngologic diseases ,Vertigo ,Humans ,Longitudinal Studies ,Hearing Loss ,Retrospective Studies - Abstract
This is a retrospective longitudinal study that uses data from the National Health Insurance Research Database (NHIRD) of Taiwan of which hypothyroid patients who received a diagnosis between 2000 and 2010 were selected and followed up until 2011. The primary outcome of this study was the occurrence of tinnitus (ICD-9-CM code 388.3). The relevant comorbidities were selected as potential confounders according to the literature, which included vertigo (ICD-9-CM code 386), insomnia (ICD-9-CM code 780), anxiety (ICD-9-CM code 300.00), and hearing loss (ICD-9-CM code 388–389). The overall incidence of tinnitus was significantly higher in the hypothyroidism cohort than in the non-hypothyroidism cohort (9.49 vs. 6.03 per 1000 person-years), with an adjusted HR of 1.35 (95% CI 1.18–1.54) after adjusting potential confounders. The incidences of tinnitus, as stratified by gender, age, comorbidity, and follow-up time, were all significantly higher in the hypothyroidism cohort than those in the non-hypothyroidism cohort. The incidence of tinnitus significantly increased with age (aHR = 1.01, 95% CI 1.01–1.02). In conclusion, we report the relationship between hypothyroidism and the increased risk for tinnitus. We also found that hypothyroidism patients are at increased risk of developing tinnitus when associated with comorbidities including vertigo, hearing loss, and insomnia.
- Published
- 2021
15. Effects of age-related tympanic-membrane material properties on sound transmission in the middle ear in a three-dimensional finite-element model
- Author
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You-Cheng Yu, Tang-Chuan Wang, and Tzu-Ching Shih
- Subjects
Sound ,Tympanic Membrane ,Finite Element Analysis ,Ear, Middle ,Health Informatics ,Acoustics ,Software ,Computer Science Applications - Abstract
The Young's modulus of the tympanic membrane (TM) is an important modeling parameter in computer simulations of the sound transmission in the ear. Understanding the material mechanics of the TM is essential to improve the coupling between the tympanic membrane and the auditory ossicles. However, the impact of the age-related Young's modulus of the TM on sound transmission is not well known. The objective of this study was to use a comprehensive finite element (FE) model to assess the impact of Young's modulus on sound transmission from the ear canal to the stapes footplate over acoustic frequencies.The FE model of the ear canal, the middle ear, and the inner ear, was constructed. The model was constructed with identical geometries and boundary conditions, but with three different Young's moduli for the TMs. The auditory ossicles, suspensory ligaments and tendons, and manubrium were also modeled as isotropic elastic materials. Beside, we evaluated the age-related Young's moduli of the TMs on sound transmission with the FE element fluid-structural interaction (FSI) model under acoustic loading conditions.The impact of the age-related Young's moduli on the sound pressure distributions in the ear canal was significant over two frequency ranges of 1.4-3.2 and 8.6-10 kHz. Meanwhile, the significant differences of the displacement of the stapes occurred at around 1.6 kHz, where the displacement of the stapes decreased from 0.352 nm to 0.287 nm.The FSI model could demonstrate the influence of Young's modulus of the TM on the transfer of sound-induced vibrations form the ear canal to the stapes footplate. The FE model may provide appropriate information to the medical device development of artificial ossicles and hearing aids.
- Published
- 2021
16. Hearing Loss - From Multidisciplinary Teamwork to Public Health
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Tang-Chuan Wang
- Subjects
Teamwork ,medicine.medical_specialty ,Nursing ,Hearing loss ,Multidisciplinary approach ,business.industry ,media_common.quotation_subject ,Public health ,medicine ,medicine.symptom ,business ,media_common - Published
- 2021
17. Increased Acquired Cholesteatoma Risk in Patients with Osteoporosis: A Retrospective Cohort Study.
- Author
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Tang-Chuan Wang, Che-Chen Lin, Chia-Der Lin, Hsiung-Kwang Chung, Ching-Yuang Wang, Ming-Hsui Tsai, and Chia-Hung Kao
- Subjects
Medicine ,Science - Abstract
Clinically, we found the increased incidence of acquired colesteatoma in the patients with osteoporosis. In this study, we used a retrospective cohort to examine this association and to investigate the possible mechanism.We conducted a population-based retrospective cohort study by using the National Health Insurance Research Database (NHIRD). We identified an osteoporosis cohort comprising 37 124 patients newly diagnosed with osteoporosis aged 20 years or older. Patients in the comparison cohort had no history of osteoporosis and were frequency matched with the patients in the osteoporosis cohort according to sex, age, and index year.The acquired cholesteatoma incidence rates for the osteoporosis and comparison cohorts were 1.12 and 0.83 per 1000 person-years, respectively. After we adjusted for confounding factors, the osteoporosis cohort exhibited a 1.32-fold increased acquired cholesteatoma risk relative to the comparison cohort (hazard ratio [HR] = 1.32, 95% confidence interval [CI] = 1.11-1.57). In addition, patients with no history of otitis media (HR = 1.33, 95% CI = 1.11-1.59), cancer (HR = 1.34, 95% CI = 1.12-1.60), or COPD (HR = 1.26, 95% CI = 1.05-1.52) in the osteoporosis cohort exhibited an increased risk of subsequent acquired cholesteatoma relative to those in the comparison cohort.Our cohort study indicated that patients with osteoporosis had a 1.31-fold increased acquired cholesteatoma risk relative to the comparison cohort. This risk was further increased in patients with comorbid otitis media. Hence, we recommend that otolaryngologists evaluate the condition of the middle ear of patients with osteoporosis.
- Published
- 2015
- Full Text
- View/download PDF
18. Noise Induced Hearing Loss and Tinnitus—New Research Developments and Remaining Gaps in Disease Assessment, Treatment, and Prevention
- Author
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Wen-Miin Liang, Ming Hsui Tsai, Tang-Chuan Wang, Yi-Wen Chen, Chia-Der Lin, Wei-Yong Lin, Ta-Yuan Chang, Ying Ju Lin, Yio-Wha Shau, and Richard S. Tyler
- Subjects
medicine.medical_specialty ,deafferentation ,Early detection ,Review ,Maladaptive plasticity ,Audiology ,lcsh:RC321-571 ,03 medical and health sciences ,0302 clinical medicine ,Noise exposure ,Neuroplasticity ,medicine ,otorhinolaryngologic diseases ,Auditory system ,tinnitus ,030223 otorhinolaryngology ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,central auditory system ,cochlear damage ,business.industry ,General Neuroscience ,hidden hearing loss ,medicine.disease ,maladaptive plasticity ,medicine.anatomical_structure ,noise induced hearing loss ,Disease assessment ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Tinnitus ,Noise-induced hearing loss ,neural plasticity - Abstract
Long-term noise exposure often results in noise induced hearing loss (NIHL). Tinnitus, the generation of phantom sounds, can also result from noise exposure, although understanding of its underlying mechanisms are limited. Recent studies, however, are shedding light on the neural processes involved in NIHL and tinnitus, leading to potential new and innovative treatments. This review focuses on the assessment of NIHL, available treatments, and development of new pharmacologic and non-pharmacologic treatments based on recent studies of central auditory plasticity and adaptive changes in hearing. We discuss the mechanisms and maladaptive plasticity of NIHL, neuronal aspects of tinnitus triggers, and mechanisms such as tinnitus-associated neural changes at the cochlear nucleus underlying the generation of tinnitus after noise-induced deafferentation. We include observations from recent studies, including our own studies on associated risks and emerging treatments for tinnitus. Increasing knowledge of neural plasticity and adaptive changes in the central auditory system suggest that NIHL is preventable and transient abnormalities may be reversable, although ongoing research in assessment and early detection of hearing difficulties is still urgently needed. Since no treatment can yet reverse noise-related damage completely, preventative strategies and increased awareness of hearing health are essential.
- Published
- 2020
19. Comparative effectiveness of simultaneous integrated boost vs sequential intensity-modulated radiotherapy for oropharyngeal or hypopharyngeal cancer patients: A population-based propensity score-matched analysis
- Author
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Ji An Liang, Tang Chuan Wang, Chun Jung Juan, Chun Ru Chien, Yao Hung Kuo, and Chia Chin Li
- Subjects
Oncology ,Adult ,Male ,medicine.medical_specialty ,endocrine system diseases ,oropharyngeal cancer ,medicine.medical_treatment ,Population ,Observational Study ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,otorhinolaryngologic diseases ,Humans ,030212 general & internal medicine ,education ,Propensity Score ,neoplasms ,Aged ,education.field_of_study ,Hypopharyngeal Neoplasms ,business.industry ,Hazard ratio ,Cancer ,Hypopharyngeal cancer ,General Medicine ,Middle Aged ,medicine.disease ,intensity-modulated radiotherapy ,Confidence interval ,Radiation therapy ,stomatognathic diseases ,Oropharyngeal Neoplasms ,030220 oncology & carcinogenesis ,simultaneous integrated boost ,Propensity score matching ,Population study ,Female ,Radiotherapy, Intensity-Modulated ,business ,sequential ,therapeutics ,hypopharyngeal cancer ,Research Article - Abstract
There were 2 common radiotherapy dose fractionation strategies in head-and-neck cancer patients (such as oropharyngeal cancer [OPC] or hypopharyngeal cancer [HPC]) treated with radiotherapy: intensity-modulated radiotherapy using simultaneous integrated boost (IMRT-SIB) and sequential IMRT (IMRT-SEQ). There is a lack of high-level clinical evidence to compare IMRT-SIB vs IMRT-SEQ specifically for OPC or HPC patients. The present study investigated the survival outcomes of OPC or HPC patients receiving definite concurrent chemoradiotherapy (CCRT) with either IMRT-SIB or IMRT-SEQ via a population-based propensity score (PS)-based analysis. The localized stage OPC or HPC patients diagnosed between 2011 and 2015 were identified based on the Health and Welfare Data Science Center database in Taiwan. These patients received definitive CCRT with either IMRT-SIB or IMRT-SEQ. We constructed a PS-matched cohort (1:1 for IMRT-SIB vs IMRT-SEQ) to balance observable potential confounders. We compared the hazard ratio (HR) of death between IMRT-SIB and IMRT-SEQ during the entire follow-up period. We also evaluated other disease outcome or subgroups. Our study population constituted 200 patients with well balance in observed covariables. The HR of death when IMRT-SIB was compared to IMRT-SEQ was 1.23 (95% confidence interval 0.84–1.80, P = .29). The results were similar for other disease outcome or subgroups. We found the survival outcome might be comparable for those treated with IMRT-SIB vs those treated with IMRT-SEQ.
- Published
- 2019
20. Effect of Transcranial Direct Current Stimulation in Patients With Tinnitus: A Meta-Analysis and Systematic Review
- Author
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Tang-Chuan Wang, Chia-Der Lin, Ta-Yuan Chang, Richard S. Tyler, Hsiung Kwang Chung, Jui-Cheng Chen, and Yung An Tsou
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,MEDLINE ,Audiology ,Transcranial Direct Current Stimulation ,Loudness ,Tinnitus ,03 medical and health sciences ,0302 clinical medicine ,otorhinolaryngologic diseases ,medicine ,Humans ,In patient ,030223 otorhinolaryngology ,Clinical Trials as Topic ,Transcranial direct-current stimulation ,business.industry ,General Medicine ,Middle Aged ,External source ,Distress ,Otorhinolaryngology ,Patient Satisfaction ,Meta-analysis ,Female ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Objectives: Subjective tinnitus is a phantom sensation experienced without any external source of sound that profoundly impacts the quality of life. Some investigations have claimed that transcranial direct current stimulation (tDCS) reduces tinnitus, but studies on tDCS have demonstrated variable results. This meta-analysis aimed to examine the effect of tDCS on patients with tinnitus. Methods: We searched for articles published through January 5, 2016, in Medline, Cochrane, EMBASE, and Google Scholar using the following keywords: tinnitus, transcranial direct current stimulation, and tDCS. The study outcomes were change in magnitude estimates of loudness (loudness), tinnitus-related distress (distress), and Tinnitus Handicap Inventory (THI). Results: Pooled results demonstrated that tDCS did not have a beneficial effect on loudness (pooled standardized difference in means = 0.674, 95% CI, –0.089 to 1.437, P = .083). Further, the pooled results demonstrated a greater reduction in distress for the tDCS group (pooled standardized difference in means = 0.634, 95% CI, 0.021-1.247, P = .043). Conclusions: We conclude that the pooled results demonstrated a greater reduction in distress for groups treated with tDCS as compared with those administered a sham treatment.
- Published
- 2017
21. Treatment Success with Titratable Thermoplastic Mandibular Advancement Devices for Obstructive Sleep Apnea: A Comparison of Patient Characteristics
- Author
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Yi Fan Wu, Chia Chang Huang, Wesley Wen Yang Lin, Tang-Chuan Wang, Michael Yuanchien Chen, Ming Hsui Tsai, Chih Jaan Tai, Yu-Fen Li, and Yung An Tsou
- Subjects
Adult ,Male ,animal structures ,Visual Analog Scale ,Cephalometry ,Visual analogue scale ,Polysomnography ,Titratable acid ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,Severity of illness ,Humans ,Medicine ,Clinical significance ,030223 otorhinolaryngology ,Sleep Apnea, Obstructive ,medicine.diagnostic_test ,business.industry ,Sleep apnea ,Equipment Design ,Middle Aged ,Craniometry ,medicine.disease ,respiratory tract diseases ,Obstructive sleep apnea ,Treatment Outcome ,030228 respiratory system ,Otorhinolaryngology ,Anesthesia ,Female ,Sleep ,business ,Mandibular Advancement ,Neck - Abstract
A titratable thermoplastic mandibular advancement devices (MAD) is clearly an effective treatment option in some patients with obstructive sleep apnea (OSA). Determining which patients may be more likely to respond to treatment with thermoplastic MADs and to adhere to treatment would be of obvious clinical relevance. This was an experimental descriptive study (N = 60). Patients with OSA were instructed to wear a titratable thermoplastic MAD for 3 months. Treatment success was defined as a ≥50% reduction from baseline in the apnea-hypopnea index (AHI) or AHI
- Published
- 2017
22. Introductory Chapter: Management of Tinnitus - The Views of Various Disciplines
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Yi-Chien Ho and Tang-Chuan Wang
- Subjects
Cognitive science ,business.industry ,InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL ,medicine ,medicine.symptom ,business ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,Tinnitus - Published
- 2019
23. Low-grade albuminuria is associated with hearing loss in non-diabetic US males
- Author
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Richard Salvi, Chia Hao Chang, Ming Hsui Tsai, Tang Chuan Wang, Chien Jen Chiu, Yi-Wen Liu, Chia-Der Lin, Ta-Yuan Chang, and Chun Jung Juan
- Subjects
Blood Glucose ,Male ,Cross-sectional study ,Comorbidity ,Severity of Illness Index ,0302 clinical medicine ,Reference Values ,030212 general & internal medicine ,glomerular filtration rate ,education.field_of_study ,diabetes ,Incidence ,Incidence (epidemiology) ,National Health and Nutritional Examination Survey (NHANES) ,General Medicine ,Middle Aged ,Nutrition Surveys ,030220 oncology & carcinogenesis ,medicine.symptom ,Risk assessment ,Research Article ,Adult ,medicine.medical_specialty ,National Health and Nutrition Examination Survey ,Hearing loss ,Population ,Observational Study ,Urinalysis ,albumin-to-creatinine ratio ,Risk Assessment ,03 medical and health sciences ,Age Distribution ,Audiometry ,Internal medicine ,Diabetes Mellitus ,medicine ,Albuminuria ,Humans ,Hearing Loss ,education ,Aged ,business.industry ,medicine.disease ,United States ,Cross-Sectional Studies ,Multivariate Analysis ,Linear Models ,business - Abstract
High levels of albuminuria have been demonstrated to associate with hearing loss in non-diabetic people, while the clinical impact of low-grade albuminuria has attracted less attention. This cross-sectional population-based study aimed to examine whether hearing loss in non-diabetic United States (US) adults is independently associated with low-grade albuminuria or reduced estimated glomeruli filtration rate (eGFR). A total of 2518 participants aged 20 to 69 years were selected from the US National Health and Nutritional Examination Survey database. Participants with diabetes or high-grade albuminuria were excluded. Hearing loss was assessed using low-frequency pure-tone average (LFPTA) thresholds (0.5, 1.0, 2.0 kHz) and high-frequency pure-tone average (HFPTA) thresholds (3.0, 4.0, 6.0, 8.0 kHz). Logistic and linear regression analyses were used to evaluate associations between renal function indicators and hearing loss. The median age of included participants was 37.4 years, and 55% of them were female. Multivariate analysis revealed that participants with urinary albumin-to-creatinine ratio (UACR) in the highest tertile had a significantly higher risk of hearing loss (OR, 1.79; 95% CI, 1.01–3.19) and higher HFPTA thresholds (β: 2.23; SE: 0.77). Participants with eGFR
- Published
- 2020
24. Comparison of Balloon Dilation and Laser Eustachian Tuboplasty in Patients with Eustachian Tube Dysfunction: A Meta-analysis
- Author
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Ming Hsui Tsai, Ching Yuang Wang, Hsiung Kwang Chung, Yung An Tsou, Ching Hsuan Huang, Tzu Ching Shih, Tang-Chuan Wang, and Chia-Der Lin
- Subjects
medicine.medical_specialty ,Tuboplasty ,Eustachian tube ,medicine.medical_treatment ,Balloon ,03 medical and health sciences ,0302 clinical medicine ,Valsalva maneuver ,Medicine ,Humans ,030223 otorhinolaryngology ,Prospective cohort study ,Ear Diseases ,medicine.diagnostic_test ,business.industry ,Eustachian Tube ,Tympanometry ,Dilatation ,Surgery ,medicine.anatomical_structure ,Otorhinolaryngology ,Strictly standardized mean difference ,030220 oncology & carcinogenesis ,Balloon dilation ,Laser Therapy ,business - Abstract
Objective We aimed to perform a meta-analysis examining balloon dilatation and laser tuboplasty for the treatment of eustachian tube dysfunction (ETD). Data Sources PubMed, Cochrane, and Embase search up to April 18, 2016, with the following keywords: eustachian, middle-ear, eustachian tuboplasty, balloon tuboplasty, laser tuboplasty, laser dilatation, and balloon dilatation. Review Methods Randomized controlled trials and prospective, retrospective, and 1-arm studies of patients with ETD treated with balloon dilatation or laser tuboplasty were included. Outcome measures were improvement of eustachian tube score (ETS) and tympanometry and Valsalva maneuver results. Results Two retrospective and 11 prospective studies were included (1063 patients; 942 treated with balloon and 121 with laser tuboplasty). Balloon tuboplasty resulted in a significant improvement of ETS (pooled standardized mean difference [SMD], 0.94; 95% confidence interval [CI], 0.23-1.66; P = .009) and, compared with laser tuboplasty, a greater tympanometry improvement rate (pooled event rate = 73% vs 13%; P = .001). Valsalva maneuver improvement rate was not different between the group results (pooled event rate = 67% vs 50%; P = .472). The maximum number of studies that provided outcome data for any one measure was only 4, and sensitivity analysis indicated ETS results may have been overly influenced by 2 studies. No balloon tuboplasty studies reported ETS data, preventing comparison between the 2 procedures. Conclusion Both procedures can improve symptoms of ETD; however, because of the limited numbers of studies reporting data of the outcomes of interest, it remains unclear if one procedure provides greater benefits.
- Published
- 2018
25. Predictors of hearing outcomes following low-dose stereotactic radiosurgery in patients with vestibular schwannomas: A retrospective cohort review
- Author
-
Tang-Chuan Wang, Chia-Der Lin, Hsiung Kwang Chung, Ryh Hsin Lin, Ching Yuang Wang, Hung Lin Lin, Ming Hsui Tsai, and Yung An Tsou
- Subjects
Adult ,Male ,Pediatrics ,medicine.medical_specialty ,medicine.medical_treatment ,Audiology ,Radiosurgery ,Dose constraints ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Patient age ,Outcome Assessment, Health Care ,otorhinolaryngologic diseases ,Medicine ,Humans ,In patient ,Hearing Loss ,Aged ,Retrospective Studies ,Aged, 80 and over ,Hearing preservation ,business.industry ,Low dose ,Retrospective cohort study ,General Medicine ,Neuroma, Acoustic ,Middle Aged ,Prognosis ,030220 oncology & carcinogenesis ,Vestibular Schwannomas ,Surgery ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Objectives Hearing deterioration is a major concern for hearing-preserved patients with vestibular schwannomas who are treated with stereotactic radiosurgery (SRS). Thus, determining which patients are more likely to have worse hearing outcomes following SRS may facilitate clinicians in deciding whether conservative policy should be applied in the interest of hearing preservation. This study aimed to define the predictors of hearing outcomes following SRS. Patients and methods This retrospective study included 100 patients who underwent low-dose SRS (12- to 13-Gy marginal dose) for vestibular schwannomas between January 2004 and January 2014. Clinical factors and hearing outcomes following radiosurgery were reviewed. Results All patients had serviceable hearing at diagnosis and prior to SRS. The median follow-up period was 6.5 years (range, 3–10 years). The hearing preservation rate in the first, third, and fifth year after radiosurgery was 89%, 68%, and 63%, respectively. A mean cochlear dose lower than 4 Gy was a favorable predictor of hearing outcome. Maximal cochlear dose, patient age, pre-treatment pure-tone average, and imaging characteristics were not associated with post-treatment hearing preservation. Our study showed an accelerated rate of deterioration of serial pure-tone average in the first 3 years, followed by a more gradual decline after radiosurgery. Conclusion Our results suggest that cochlear dose constraint is the most crucial factor for hearing preservation. This study provides insight into the rate of hearing preservation and the pattern of hearing deterioration following radiosurgery and can help clinicians advise patients of hearing outcomes following SRS.
- Published
- 2017
26. Nasal Packing after Functional Endoscopic Sinus Surgery
- Author
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Hung‐Ta Hsiao and Tang‐Chuan Wang
- Subjects
03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,030220 oncology & carcinogenesis ,Ethmoidectomy ,Medicine ,Functional endoscopic sinus surgery ,030223 otorhinolaryngology ,business ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,Surgery ,Nasal packing - Published
- 2017
27. Absorbable and nonabsorbable packing after functional endoscopic sinus surgery: systematic review and meta-analysis of outcomes
- Author
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Li Tai Tsai, Tang-Chuan Wang, Ming Hsui Tsai, Chih Jaan Tai, Yu-Fen Li, and Yung An Tsou
- Subjects
medicine.medical_specialty ,Efficacy ,Functional endoscopic sinus surgery ,Review Article ,Postoperative Hemorrhage ,law.invention ,Transanal Endoscopic Surgery ,Packing ,Randomized controlled trial ,law ,medicine ,Humans ,Absorbable ,Nonabsorbable ,FESS ,Sinusitis ,Synechia ,Rhinitis ,business.industry ,Nasal ,General Medicine ,medicine.disease ,Hemostasis, Surgical ,Surgery ,Meta-analysis ,Epistaxis ,Treatment Outcome ,Otorhinolaryngology ,Chronic Disease ,Neurosurgery ,business - Abstract
The purpose of the study was to perform a systematic review and meta-analysis of the literature to compare the efficacy (and other postoperative outcomes) of nonabsorbable versus absorbable nasal packing after functional endoscopic sinus surgery (FESS) for the treatment of chronic rhinosinusitis. Studies were considered for inclusion if they were published in English language, were randomized clinical trials, and reported on outcomes following postoperative synechia. The primary outcome for meta-analysis was the incidence of postoperative synechia; pooled odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated using fixed-effects models. Five studies, involving 241 nasal cavities in each treatment group, were included in the systematic review. The prevalence of synechia ranged from 4.6 to 8.0 % in the absorbable groups and from 8.0 to 35.7 % in the nonabsorbable groups. Postoperative bleeding was lower in the absorbable groups, whereas there was no clear finding regarding postoperative pain. Postoperative edema was generally similar between groups. There were no consistent findings regarding bleeding and pain on packing removal. Two studies using the same type of packing material were included in the meta-analysis. The combined OR (0.33, 95 % CI 0.04–2.78) for postoperative synechia did not significantly favor (P = 0.308) absorbable packing over nonabsorbable packing. Although there is some evidence in the available literature that absorbable nasal packing may provide superior outcomes to nonabsorbable packing after FESS, the lack of homogeneity between studies makes definitive conclusions impossible. Further randomized clinical trials are needed to compare the efficacy of different types of absorbable nasal packing for preventing synechia after FESS.
- Published
- 2014
28. Reliability of the Minimum Masking Level as Outcome Variable in Tinnitus Clinical Research.
- Author
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Mancini, Patricia C., Tyler, Richard S., Hyung Jin Jun, Tang-Chuan Wang, Ji, Helena, Stocking, Christina, Secor, Carrie, Rojas-Roncancio, Eveling, and Witt, Shelley
- Subjects
TINNITUS treatment ,AUDITORY perception ,STATISTICAL correlation ,MASKING (Psychology) ,QUESTIONNAIRES ,RELIABILITY (Personality trait) ,RESEARCH funding ,LOUDNESS ,STATISTICAL reliability ,DESCRIPTIVE statistics - Abstract
Purpose: The minimum masking level (MML) is the minimum intensity of a stimulus required to just totally mask the tinnitus. Treatments aimed at reducing the tinnitus itself should attempt to measure the magnitude of the tinnitus. The objective of this study was to evaluate the reliability of the MML. Method: Sample consisted of 59 tinnitus patients who reported stable tinnitus. We obtained MML measures on two visits, separated by about 2-3 weeks. We used two noise types: speech-shaped noise and high-frequency emphasis noise. We also investigated the relationship between the MML and tinnitus loudness estimates and the Tinnitus Handicap Questionnaire (THQ). Results: There were differences across the different noise types. The within-session standard deviation averaged across subjects varied between 1.3 and 1.8 dB. Across the two sessions, the Pearson correlation coefficients, range was r = .84. There was a weak relationship between the dB SL MML and loudness, and between the MML and the THQ. A moderate correlation (r = .44) was found between the THQ and loudness estimates. Conclusions: We conclude that the dB SL MML can be a reliable estimate of tinnitus magnitude, with expected standard deviations in trained subjects of about 1.5 dB. It appears that the dB SL MML and loudness estimates are not closely related. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
29. Low-grade albuminuria is associated with hearing loss in non-diabetic US males: A cross-sectional analysis of 1999-2004 national health and nutrition examination survey.
- Author
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Tang-Chuan Wang, Ta-Yuan Chang, Salvi, Richard, Chun-Jung Juan, Yi-Wen Liu, Chia-Hao Chang, Chien-Jen Chiu, Chia-Der Lin, Ming-Hsui Tsai, Wang, Tang-Chuan, Chang, Ta-Yuan, Juan, Chun-Jung, Liu, Yi-Wen, Chang, Chia-Hao, Chiu, Chien-Jen, Lin, Chia-Der, and Tsai, Ming-Hsui
- Published
- 2020
- Full Text
- View/download PDF
30. Comparative effectiveness of simultaneous integrated boost vs sequential intensity-modulated radiotherapy for oropharyngeal or hypopharyngeal cancer patients: A population-based propensity score-matched analysis.
- Author
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Yao-Hung Kuo, Ji-An Liang, Tang-Chuan Wang, Chun-Jung Juan, Chia-Chin Li, Chun-Ru Chien, Kuo, Yao-Hung, Liang, Ji-An, Wang, Tang-Chuan, Juan, Chun-Jung, Li, Chia-Chin, and Chien, Chun-Ru
- Published
- 2019
- Full Text
- View/download PDF
31. Development of Subcortical Pitch Representation in Three-Month-Old Chinese Infants
- Author
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Ching-Yuan Wang, Tang-Chuan Wang, John T. Sabol, Fuh-Cherng Jeng, Chia-Der Lin, Grant R. Hollister, Garrett N. Mayhugh, and Meng-Shih Chou
- Subjects
Male ,medicine.medical_specialty ,Old Chinese ,Experimental and Cognitive Psychology ,Audiology ,Mandarin Chinese ,050105 experimental psychology ,03 medical and health sciences ,0302 clinical medicine ,Child Development ,medicine ,Humans ,0501 psychology and cognitive sciences ,Prospective Studies ,Prospective cohort study ,Pitch Perception ,05 social sciences ,Phase error ,Infant, Newborn ,Brain ,Infant ,Frequency following response ,Early infancy ,Child development ,Brain Waves ,Sensory Systems ,language.human_language ,Developmental trajectory ,language ,Female ,Psychology ,030217 neurology & neurosurgery - Abstract
This study investigated the development of subcortical pitch processing, as reflected by the scalp-recorded frequency-following response, during early infancy. Thirteen Chinese infants who were born and raised in Mandarin-speaking households were recruited to partake in this study. Through a prospective-longitudinal study design, infants were tested twice: at 1–3 days after birth and at three months of age. A set of four contrastive Mandarin pitch contours were used to elicit frequency-following responses. Frequency Error and Pitch Strength were derived to represent the accuracy and magnitude of the elicited responses. Paired-samples t tests were conducted and demonstrated a significant decrease in Frequency Error and a significant increase in Pitch Strength at three months of age compared to 1–3 days after birth. Results indicated the developmental trajectory of subcortical pitch processing during the first three months of life.
- Published
- 2016
32. Subcortical neural representation to Mandarin pitch contours in American and Chinese newborns
- Author
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Fuh-Cherng Jeng, Tang-Chuan Wang, and Chia-Der Lin
- Subjects
Male ,Speech perception ,Sound Spectrography ,Acoustics and Ultrasonics ,Voice Quality ,Acoustics ,Speech recognition ,Taiwan ,behavioral disciplines and activities ,Mandarin Chinese ,050105 experimental psychology ,Speech Acoustics ,03 medical and health sciences ,0302 clinical medicine ,Child Development ,Arts and Humanities (miscellaneous) ,Phonetics ,Vowel ,otorhinolaryngologic diseases ,medicine ,Humans ,0501 psychology and cognitive sciences ,Set (psychology) ,Pitch Perception ,Pitch contour ,Ohio ,Brain Mapping ,medicine.diagnostic_test ,05 social sciences ,Age Factors ,Infant, Newborn ,Brain ,Electroencephalography ,Speech processing ,humanities ,language.human_language ,Acoustic Stimulation ,language ,Evoked Potentials, Auditory ,Speech Perception ,Female ,Audiometry ,Cues ,Psychology ,Audiometry, Speech ,psychological phenomena and processes ,030217 neurology & neurosurgery - Abstract
Voice pitch carries important information for speech understanding. This study examines the neural representation of voice pitch at the subcortical level, as reflected by the scalp-recorded frequency-following responses from ten American and ten Chinese newborns. By utilizing a set of four distinctive Mandarin pitch contours that mimic the English vowel /yi/, the results indicate that the rising and dipping pitch contours produce significantly better tracking accuracy and larger response amplitudes than the falling pitch contour. This finding suggests a hierarchy of potential stimuli when testing neonates who are born in a tonal or non-tonal linguistic environment.
- Published
- 2016
33. Risk of depression in patients with chronic rhinosinusitis: A nationwide population-based retrospective cohort study
- Author
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Cheng-Li Lin, Che-Lun Hsu, Tang-Chuan Wang, Fung Chang Sung, Yu-Jhen Huang, and Te Chun Shen
- Subjects
Adult ,Male ,Pediatrics ,medicine.medical_specialty ,animal structures ,Databases, Factual ,Population ,Taiwan ,Comorbidity ,Cohort Studies ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Risk Factors ,otorhinolaryngologic diseases ,medicine ,Prevalence ,Humans ,030212 general & internal medicine ,Sinusitis ,030223 otorhinolaryngology ,education ,Depression (differential diagnoses) ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Rhinitis ,education.field_of_study ,business.industry ,Proportional hazards model ,Depression ,Incidence (epidemiology) ,Incidence ,Hazard ratio ,Retrospective cohort study ,respiratory system ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Clinical Psychology ,Chronic Disease ,Female ,business ,Cohort study - Abstract
Depression is prevalent in patients with chronic rhinosinusitis (CRS). However, no population-based study has ever investigated this relationship. We used nationwide population insurance data to conduct a retrospective cohort study to evaluate the subsequent risk of depression among patients with CRS.We used the National Health Insurance Research Database (NHIRD) of Taiwan identified 15,371 CRS patients diagnosed during 2000-2010. The non-CRS group consisted of 61,484 individuals without CRS frequency matched by sex, age, and the year of diagnosis. The occurrence of depression was monitored until the end of 2011. The hazard ratios (HRs) of depression were estimated using the Cox proportional hazards model after adjusting for demographic characteristics and comorbidities.The overall incidence of depression was 77% higher in the CRS group than in the non-CRS group (8.25 vs. 4.66/1000 person-years, p0.001), with an adjusted HR of 1.56 (95% confidence interval=1.43-1.70). Further data analyses revealed that the adjusted HRs of depression in the CRS group compared with the non-CRS group by sex, age, urbanization level, monthly income, occupation category, and comorbidity were all significant. However, there was no difference in incidences of depression between CRS patients with and without surgical treatment (8.31 vs. 8.24/1000 person-years).The present study suggests that patients with CRS are at an increased risk of depression, compared with those without CRS. Therefore, we should pay attention to the psychiatric status of these patients and provide adequate support for them.
- Published
- 2016
34. Survey on the Effectiveness of Dietary Supplements to Treat Tinnitus
- Author
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Marlan R. Hansen, Tang-Chuan Wang, Claudia Coelho, Pan Tao, Richard S. Tyler, Haihong Ji, Shelley Witt, Eveling Rojas-Roncancio, Bruce J. Gantz, and Hyung-Jin Jun
- Subjects
Male ,medicine.medical_specialty ,Cross-sectional study ,MEDLINE ,Vitamin b complex ,Audiology ,03 medical and health sciences ,Speech and Hearing ,Tinnitus ,0302 clinical medicine ,Surveys and Questionnaires ,Medicine ,Humans ,Magnesium ,030223 otorhinolaryngology ,Adverse effect ,Melatonin ,Flavonoids ,business.industry ,Plant Extracts ,Hyperacusis ,Central Nervous System Depressants ,Ginkgo biloba ,Middle Aged ,Trace Elements ,Vitamin B 12 ,Zinc ,Cross-Sectional Studies ,Dietary Supplements ,Vitamin B Complex ,Female ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Purpose We surveyed the benefit of dietary supplements to treat tinnitus and reported adverse effects. Method A website was created for people with tinnitus to complete a variety of questions. Results The 1,788 subjects who responded to questionnaires came from 53 different countries; 413 (23.1%) reported taking supplements. No effect on tinnitus was reported in 70.7%, improvement in 19.0%, and worsening in 10.3%. Adverse effects were reported in 6% ( n = 36), including bleeding, diarrhea, headache, and others. Supplements were reported to be helpful for sleep: melatonin (effect size, d = 1.228) and lipoflavonoid ( d = 0.5244); emotional reactions: melatonin ( d = 0.6138) and lipoflavonoid ( d = 0.457); hearing: Ginkgo biloba ( d = 0.3758); and concentration Ginkgo biloba ( d = 0.3611). The positive, subjective reports should be interpreted cautiously; many might have reported a positive effect because they were committed to treatment and expected a benefit. Users of supplements were more likely to have loudness hyperacusis and to have a louder tinnitus. Conclusions The use of dietary supplements to treat tinnitus is common, particularly with Ginkgo biloba , lipoflavonoids, magnesium, melatonin, vitamin B12, and zinc. It is likely that some supplements will help with sleep for some patients. However, they are generally not effective, and many produced adverse effects. We concluded that dietary supplements should not be recommended to treat tinnitus but could have a positive outcome on tinnitus reactions in some people.
- Published
- 2016
35. Risk factors affect the survival outcome of hard palatal and maxillary alveolus squamous cell carcinoma: 10-year review in a tertiary referral center
- Author
-
Ching Chia Lin, Chun Hun Hua, Tang-Chuan Wang, Yung An Tsou, Hsien Chang Tseng, and Ming Hsui Tsai
- Subjects
Palate, Hard ,Reoperation ,medicine.medical_specialty ,Antineoplastic Agents ,Disease-Free Survival ,Risk Factors ,Alveolar Process ,Humans ,Medicine ,Neoplasm Invasiveness ,Basal cell carcinoma ,Risk factor ,General Dentistry ,Neoplasm Staging ,Retrospective Studies ,Maxillary Neoplasms ,Salvage Therapy ,Palatal Neoplasms ,Soft palate ,business.industry ,Infratemporal fossa ,Temporal Bone ,Cancer ,Radiotherapy Dosage ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Neoadjuvant Therapy ,Surgery ,Survival Rate ,Treatment Outcome ,medicine.anatomical_structure ,Otorhinolaryngology ,Epidermoid carcinoma ,Chemotherapy, Adjuvant ,Carcinoma, Squamous Cell ,Neck Dissection ,Radiotherapy, Adjuvant ,Hard palate ,Cisplatin ,Neoplasm Recurrence, Local ,Palate, Soft ,Oral Surgery ,business ,Follow-Up Studies - Abstract
Objective Hard palatal cancer is relatively rare in the head and neck region. Treatment outcome, risk factors that lead to poor survival outcome, and treatment strategy are still controversial. Study design Retrospective study in a tertiary medical center. Results Surgery is a better treatment strategy than concurrent chemoradiation therapy (CCRT) for achieving positive survival outcomes. We also found a higher surgical salvage rate in patients with hard palatal cancer who had local recurrence or neck relapse. Soft palate or infratemporal fossa involvement had poor outcomes. Ulcerative tumor features, tumor volumes larger than 10 mL, and local recurrent tumors that could not undergo salvage surgery also had poorer survival outcomes in our study. Conclusion Surgical management is still the first choice for patients with hard palate or alveolus squamous cell carcinomas even when patients had local or neck regional recurrence.
- Published
- 2010
36. Increased risk of tinnitus in patients with temporomandibular disorder: a retrospective population-based cohort study
- Author
-
Chia-Hung Kao, Tang-Chuan Wang, Ming-Chia Lin, Cheng-Li Lin, Chun-Feng Lee, and Hui-Tzu Lin
- Subjects
Male ,medicine.medical_specialty ,TMJ disorders ,National Health Programs ,Hearing loss ,Taiwan ,Comorbidity ,Risk Assessment ,Cohort Studies ,03 medical and health sciences ,Tinnitus ,0302 clinical medicine ,Risk Factors ,Internal medicine ,otorhinolaryngologic diseases ,medicine ,Humans ,Hearing Loss ,Aged ,Proportional Hazards Models ,Retrospective Studies ,business.industry ,Hazard ratio ,Retrospective cohort study ,030206 dentistry ,General Medicine ,Middle Aged ,Temporomandibular Joint Disorders ,medicine.disease ,Otorhinolaryngology ,Relative risk ,Cohort ,Physical therapy ,Female ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
This study determined whether there is an increased risk of tinnitus in patients with temporomandibular joint (TMJ). We used information from health insurance claims obtained from Taiwan National Health Insurance (TNHI). Patients aged 20 years and older who were newly diagnosed with TMJ disorder served as the study cohort. The demographic factors and comorbidities that may be associated with tinnitus were also identified, including age, sex, and comorbidities of hearing loss, noise effects on the inner ear, and degenerative and vascular ear disorders. A higher proportion of TMJ disorder patients suffered from hearing loss (5.30 vs. 2.11 %), and degenerative and vascular ear disorders (0.20 vs. 0.08 %) compared with the control patients. The crude hazard ratio (HR) of tinnitus in the TMJ disorder cohort was 2.73-fold higher than that in the control patients, with an adjusted HR of 2.62 (95 % CI = 2.29–3.00). The comorbidity-specific TMJ disorder cohort to the control patients’ adjusted HR of tinnitus was higher for patients without comorbidity (adjusted HR = 2.75, 95 % CI = 2.39–3.17). We also observed a 3.22-fold significantly higher relative risk of developing tinnitus within the 3-year follow-up period (95 % CI = 2.67–3.89). Patients with TMJ disorder might be at increased risk of tinnitus.
- Published
- 2014
37. Recording frequency-following responses to voice pitch in guinea pigs: preliminary results
- Author
-
Tang-Chuan Wang, Chia-Der Lin, Fuh-Cherng Jeng, and Meng-Shih Chou
- Subjects
Male ,medicine.medical_specialty ,Voice pitch ,Computer science ,Guinea Pigs ,Experimental and Cognitive Psychology ,Pilot Projects ,Brain waves ,Audiology ,Neuropsychological Tests ,Background noise ,Animal model ,medicine ,Animals ,Pitch Perception ,Reliability (statistics) ,Communication ,business.industry ,Slope error ,Phase error ,Brain ,Reproducibility of Results ,Electroencephalography ,Sensory Systems ,Feasibility Studies ,Female ,business - Abstract
Although scalp-recorded frequency-following response (FFR) to voice pitch has shown great potential to examine pitch processing mechanisms in human participants and animals, few reports have addressed the test-retest reliability of such a response in an animal model. The purpose of this study was to investigate the feasibility and reliability of recording such a response in an animal model and to evaluate the extent to which the response could be separated from background noise. A Chinese monosyllable with a rising pitch was used to elicit the FFR to voice pitch in four guinea pigs. Four objective measures (Root-Mean-Square, Amplitude, Tracking Accuracy, Frequency Error, and Slope Error) were computed from recorded brain waves and were used to examine the phase-locking magnitude and test-retest reliability of the response. Results demonstrated that the animal model produced FFR trends that were repeatable, reliable, and significantly different from responses to the background noise.
- Published
- 2014
38. Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation
- Author
-
Chuan-Mu Chen, Calvin Yu-Chian Chen, Tang-Chuan Wang, Hung-Jin Huang, Chih Jaan Tai, Yung An Tsou, Massachusetts Institute of Technology. Computational and Systems Biology Program, and Chen, Calvin Yu-Chian
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Article Subject ,Paranasal Sinus Inverted Papilloma ,Inverted papilloma ,lcsh:Medicine ,Plunc ,Biology ,General Biochemistry, Genetics and Molecular Biology ,Malignant transformation ,Proliferating Cell Nuclear Antigen ,CDC2 Protein Kinase ,medicine ,Carcinoma ,Humans ,Aged ,Glycoproteins ,Papilloma, Inverted ,General Immunology and Microbiology ,lcsh:R ,General Medicine ,Sinonasal Tract ,Middle Aged ,Phosphoproteins ,Prognosis ,medicine.disease ,Cyclin-Dependent Kinases ,Gene Expression Regulation, Neoplastic ,Cell Transformation, Neoplastic ,Ki-67 Antigen ,Ki-67 ,Carcinoma, Squamous Cell ,biology.protein ,Papilloma ,Female ,Neoplasm Recurrence, Local ,Tumor Suppressor Protein p53 ,Paranasal Sinus Neoplasms ,Research Article - Abstract
The recurrent sinonasal inverted papilloma (IP) could be transformed to sinonasal squamous cell carcinoma. We use protein expression patterns by immunohistochemical method to see whether the expression of p53, p16, p21, and p27 belongs to cell-cycle-regulators and PCNA (proliferating cell nuclear antigen) and Ki-67 the proliferation markers in sixty patients with sinonasal inverted papilloma, and 10 of them with squamous cell carcinoma transformation. Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell carcinoma transformation of sinonasal tract compared with inverted papilloma were revealed. No variation of p16, p21, PLUNC (palate, lung, and nasal epithelium clone protein) and p53 expression was correlated to sinonasal IP malignant transformation by multivariate survey. However, we found elevated PLUNC expression in IPs with multiple recurrences. Finally, we found that PCNA, p27 may interact with CDK1 which promote IP cell proliferation and correlate to sinonasal squamous cell carcinoma. Ki-67 could work throughout the cell cycles to cause malignant transformation. In conclusion, this is a first study showing the correlation of Ki-67, PCNA interacted with CDK1 might lead to malignant transformation. Elevated PLUNC expression in the sinonasal IPs was related to multiple recurrences in human., National Science Council of Taiwan (Grant NSC101-2314-B-039-013-MY3), National Science Council of Taiwan (Grant NSC102-2325-B039-001), National Science Council of Taiwan (Grant NSC102-2221-E-468-027), China Medical University (Grant CMU102-BC-3), Asia University (Grant ASIA100-CMU-2), Asia University (Grant ASIA101-CMU-2), Asia University (Grant 102-ASIA-07), China Medical University Hospital (Grant DMR-102-001), China Medical University Hospital (Grant DMR-103-025), China Medical University Hospital (Grant DMR-103-058), China Medical University Hospital (Grant DMR-103-001), China Medical University Hospital (Grant DMR-103-096)
- Published
- 2014
- Full Text
- View/download PDF
39. Relationships between imaging characteristics and hearing levels in patients with vestibular schwannomas treated by stereotactic radiosurgery
- Author
-
Tang-Chuan Wang
- Subjects
medicine.medical_specialty ,Oncology ,business.industry ,Vestibular Schwannomas ,medicine.medical_treatment ,medicine ,In patient ,Hematology ,Radiology ,business ,Radiosurgery - Published
- 2016
40. Development of subcortical pitch representation in three-month-old Chinese infants
- Author
-
Garrett N. Mayhugh, Tang-Chuan Wang, Fuh-Cherng Jeng, Chia-Der Lin, Grant R. Hollister, John T. Sabol, and Ching-Yuan Wang
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Old Chinese ,Acoustics and Ultrasonics ,Representation (systemics) ,Phase error ,Audiology ,Early infancy ,Mandarin Chinese ,language.human_language ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Developmental trajectory ,Arts and Humanities (miscellaneous) ,language ,medicine ,Psychology ,Set (psychology) ,030217 neurology & neurosurgery - Abstract
This study investigated the development of subcortical pitch processing, as reflected by the scalp-recorded frequency-following response, during early infancy. Thirteen Chinese infants who were born and raised in Mandarin-speaking households were recruited to partake in this study. Through a prospective-longitudinal study design, infants were tested twice: at 1–3 days after birth and at three months of age. A set of four contrastive Mandarin pitch contours were used to elicit frequency-following responses. Frequency Error and Pitch Strength were derived to represent the accuracy and magnitude of the elicited responses. Paired-samples t tests were conducted and demonstrated a significant decrease in frequency error and a significant increase in pitch strength at three months of age compared to 1–3 days after birth. Results indicated the developmental trajectory of subcortical pitch processing during the first three months of life.
- Published
- 2016
41. Survey on the Effectiveness of Dietary Supplements to Treat Tinnitus.
- Author
-
Coelho, Claudia, Tyler, Richard, Haihong Ji, Rojas-Roncancio, Eveling, Witt, Shelley, Pan Tao, Hyung-Jin Jun, Tang Chuan Wang, Hansen, Marlan R., and Gantza, Bruce J.
- Subjects
CHI-squared test ,DIETARY supplements ,FLAVONOIDS ,GINKGO ,MELATONIN ,QUESTIONNAIRES ,SLEEP ,STATISTICS ,T-test (Statistics) ,TINNITUS ,WORLD Wide Web ,HYPERACUSIS ,LOGISTIC regression analysis ,DATA analysis ,TREATMENT effectiveness ,CROSS-sectional method ,DATA analysis software ,ODDS ratio ,MANN Whitney U Test ,THERAPEUTICS - Abstract
Purpose: We surveyed the benefit of dietary supplements to treat tinnitus and reported adverse effects. Method: A website was created for people with tinnitus to complete a variety of questions. Results: The 1,788 subjects who responded to questionnaires came from 53 different countries; 413 (23.1 %) reported taking supplements. No effect on tinnitus was reported in 70.7%, improvement in 19.0%, and worsening in 10.3%. Adverse effects were reported in 6% (n = 36), including bleeding, diarrhea, headache, and others. Supplements were reported to be helpful for sleep: melatonin (effect size, d = 1.228) and lipoflavonoid (d = 0.5244); emotional reactions: melatonin (d = 0.6138) and lipoflavonoid (d = 0.457); hearing: Ginkgo biloba (d = 0.3758); and concentration Ginkgo biloba (d = 0.3611). The positive, subjective reports should be interpreted cautiously; many might have reported a positive effect because they were committed to treatment and expected a benefit. Users of supplements were more likely to have loudness hyperacusis and to have a louder tinnitus. Conclusions: The use of dietary supplements to treat tinnitus is common, particularly with Ginkgo biloba, lipoflavonoids, magnesium, melatonin, vitamin B12, and zinc. It is likely that some supplements will help with sleep for some patients. However, they are generally not effective, and many produced adverse effects. We concluded that dietary supplements should not be recommended to treat tinnitus but could have a positive outcome on tinnitus reactions in some people. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
42. Development of Subcortical Pitch Representation in Three-Month-Old Chinese Infants.
- Author
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Fuh-Cherng Jeng, Chia-Der Lin, Meng-Shih Chou, Hollister, Grant R., Sabol, John T., Mayhugh, Garrett N., Tang-Chuan Wang, and Ching-Yuan Wang
- Subjects
AUDITORY perception testing ,CHINESE people ,EXPERIMENTAL design ,INFANT development ,LANGUAGE acquisition ,LONGITUDINAL method ,SOUND ,T-test (Statistics) ,SOUND spectrography - Abstract
This study investigated the development of subcortical pitch processing, as reflected by the scalp-recorded frequency-following response, during early infancy. Thirteen Chinese infants who were born and raised in Mandarin-speaking households were recruited to partake in this study. Through a prospective-longitudinal study design, infants were tested twice: at 1-3 days after birth and at three months of age. A set of four contrastive Mandarin pitch contours were used to elicit frequency-following responses. Frequency Error and Pitch Strength were derived to represent the accuracy and magnitude of the elicited responses. Paired-samples t tests were conducted and demonstrated a significant decrease in Frequency Error and a significant increase in Pitch Strength at three months of age compared to 1-3 days after birth. Results indicated the developmental trajectory of subcortical pitch processing during the first three months of life. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
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43. RECORDING FREQUENCY−FOLLOWING RESPONSES TO VOICE PITCH IN GUINEA PIGS: PRELIMINARY RESULTS.
- Author
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MENG-SHIH CHOU, CHIA-DER LIN, TANG-CHUAN WANG, and FUH-CHERNG JENG
- Subjects
ELECTROPHYSIOLOGY methodology ,ANALYSIS of variance ,ANIMAL experimentation ,BIOLOGICAL models ,STATISTICAL correlation ,EXPERIMENTAL design ,GUINEA pigs ,MUSICAL perception ,INTONATION (Phonetics) ,NOISE ,REGRESSION analysis ,RESEARCH evaluation ,RESEARCH funding ,STATISTICS ,T-test (Statistics) ,HUMAN voice ,PILOT projects ,DATA analysis ,PRE-tests & post-tests ,REPEATED measures design ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Although scalp-recorded frequency-following response (FFR) to voice pitch has shown great potential to examine pitch processing mechanisms in human participants and animals, few reports have addressed the test-retest reliability of such a response in an animal model. The purpose of this study was to investigate the feasibility and reliability of recording such a response in an animal model and to evaluate the extent to which the response could be separated from background noise. A Chinese monosyllable with a rising pitch was used to elicit the FFR to voice pitch in four guinea pigs. Four objective measures (Root-Mean-Square, Amplitude, Tracking Accuracy, Frequency Error, and Slope Error) were computed from recorded brain waves and were used to examine the phase-locking magnitude and test-retest reliability of the response. Results demonstrated that the animal model produced FFR trends that were repeatable, reliable, and significantly different from responses to the background noise. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
44. Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation.
- Author
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Yung-An Tsou, Hung-Jin Huang, Tang-Chuan Wang, Chih-Jaan Tai, Chuan-Mu Chen, and Calvin Yu-Chian Chen
- Abstract
The recurrent sinonasal inverted papilloma (IP) could be transformed to sinonasal squamous cell carcinoma. We use protein expression patterns by immunohistochemical method to see whether the expression of p53, p16, p21, and p27 belongs to cellcycle-regulators and PCNA (proliferating cell nuclear antigen) and Ki-67 the proliferation markers in sixty patients with sinonasal inverted papilloma, and 10 of them with squamous cell carcinoma transformation. Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell carcinoma transformation of sinonasal tract compared with inverted papilloma were revealed. No variation of p16, p21, PLUNC (palate, lung, and nasal epithelium clone protein) and p53 expression was correlated to sinonasal IP malignant transformation bymultivariate survey. However, we found elevated PLUNC expression in IPs with multiple recurrences. Finally, we found that PCNA, p27 may interact with CDK1 which promote IP cell proliferation and correlate to sinonasal squamous cell carcinoma. Ki-67 could work throughout the cell cycles to cause malignant transformation. In conclusion, this is a first study showing the correlation ofKi-67, PCNAinteractedwithCDK1 might lead to malignant transformation. Elevated PLUNC expression in the sinonasal IPs was related to multiple recurrences in human. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
45. Manganese and Lipoflavonoid Plus® to Treat Tinnitus: A Randomized Controlled Trial.
- Author
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Rojas-Roncancio, Eveling, Tyler, Richard, Hyung-Jin Jun, Tang-Chuan Wang, Haihong Ji, Coelho, Claudia, Witt, Shelley, Hansen, Marian R., and Gantz, Bruce J.
- Subjects
- *
DIETARY supplements , *MANGANESE , *AUDITORY perception , *COMBINATION drug therapy , *QUESTIONNAIRES , *RESEARCH funding , *STATISTICAL sampling , *TINNITUS , *LOUDNESS , *RANDOMIZED controlled trials , *THERAPEUTICS - Abstract
Background: Several tinnitus sufferers suggest that manganese has been helpful with their tinnitus. Purpose: We tested this in a controlled experiment where participants were committed to taking manganese and Lipoflavonoid Plus® to treat their tinnitus. Research Design: Randomized controlled trial. Study Sample: 40 participants were randomized to receive both manganese and Lipoflavonoid Plus® for 6 months, or Lipoflavonoid Plus® only (as the control). Data Collection and Analysis: Pre- and postmeasures were obtained with the Tinnitus Handicap Questionnaire, Tinnitus Primary Functions Questionnaire, and tinnitus loudness and annoyance ratings. An audiologist performed the audiogram, the tinnitus loudness match, and minimal masking level. Results: Twelve participants were dropped out of the study because of the side effects or were lost to follow-up. In the manganese group, 1 participant (out of 12) showed a decrease in the questionnaires, and another showed a decrease in the loudness and annoyance ratings. No participants from the control group (total 16) showed a decrease in the questionnaires ratings. Two participants in the control group reported a loudness decrement and one reported an annoyance decrement. Conclusions: We were not able to conclude that either manganese or Lipoflavonoid Plus® is an effective treatment for tinnitus. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
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