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Low-grade albuminuria is associated with hearing loss in non-diabetic US males
- Source :
- Medicine
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- High levels of albuminuria have been demonstrated to associate with hearing loss in non-diabetic people, while the clinical impact of low-grade albuminuria has attracted less attention. This cross-sectional population-based study aimed to examine whether hearing loss in non-diabetic United States (US) adults is independently associated with low-grade albuminuria or reduced estimated glomeruli filtration rate (eGFR). A total of 2518 participants aged 20 to 69 years were selected from the US National Health and Nutritional Examination Survey database. Participants with diabetes or high-grade albuminuria were excluded. Hearing loss was assessed using low-frequency pure-tone average (LFPTA) thresholds (0.5, 1.0, 2.0 kHz) and high-frequency pure-tone average (HFPTA) thresholds (3.0, 4.0, 6.0, 8.0 kHz). Logistic and linear regression analyses were used to evaluate associations between renal function indicators and hearing loss. The median age of included participants was 37.4 years, and 55% of them were female. Multivariate analysis revealed that participants with urinary albumin-to-creatinine ratio (UACR) in the highest tertile had a significantly higher risk of hearing loss (OR, 1.79; 95% CI, 1.01–3.19) and higher HFPTA thresholds (β: 2.23; SE: 0.77). Participants with eGFR
- Subjects :
- Blood Glucose
Male
Cross-sectional study
Comorbidity
Severity of Illness Index
0302 clinical medicine
Reference Values
030212 general & internal medicine
glomerular filtration rate
education.field_of_study
diabetes
Incidence
Incidence (epidemiology)
National Health and Nutritional Examination Survey (NHANES)
General Medicine
Middle Aged
Nutrition Surveys
030220 oncology & carcinogenesis
medicine.symptom
Risk assessment
Research Article
Adult
medicine.medical_specialty
National Health and Nutrition Examination Survey
Hearing loss
Population
Observational Study
Urinalysis
albumin-to-creatinine ratio
Risk Assessment
03 medical and health sciences
Age Distribution
Audiometry
Internal medicine
Diabetes Mellitus
medicine
Albuminuria
Humans
Hearing Loss
education
Aged
business.industry
medicine.disease
United States
Cross-Sectional Studies
Multivariate Analysis
Linear Models
business
Subjects
Details
- ISSN :
- 15365964 and 00257974
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....b7d16621e6dc4121e6fd70d97d7c7a02