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58 results on '"Supersonic imagine"'

1. Smart Optical and Ultrasound Diagnostic of Breast Cancer (SOLUS)

Author

Politecnico di Milano, Commissariat A L'energie Atomique, SuperSonic Imagine, VERMON, University College, London, MICRO PHOTON DEVICES (MPD), EIBIR - European Institute for biomedical imaging research, IC-HAUS, and Pietro Panizza, Dr

Published
2023

3. Reflection matrix approach for quantitative ultrasound imaging of scattering media

Author

Aubry, Alexandre, Lambert, William, Cobus, Laura, Fink, Mathias, Institut Langevin - Ondes et Images (UMR7587) (IL), Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS), SuperSonic Imagine, Supersonic Imagine, and Supersonic Imagine-Supersonic Imagine

Subjects
[PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract

International audience; We present a physically intuitive matrix approach for wave imaging and characterization in scattering media. The experimental proof-of-concept is performed with ultrasonic waves, but this approach can be applied to any field of wave physics for which multi-element technology is available. The concept is that focused beamforming enables the synthesis, in transmit and receive, of an array of virtual transducers which map the entire medium to be imaged. The inter-element responses of this virtual array form a focused reflection matrix from which spatial maps of various characteristics of the propagating wave can be retrieved. Here we demonstrate: (i) a local focusing criterion that enables the imaging quality to be evaluated everywhere inside the medium, including in random speckle; (ii) a tomographic measurement of wave velocity, which allows for aberration corrections in the original image; (iii) an highly resolved spatial mapping of the prevalence of multiple scattering, which constitutes a new and unique contrast for ultrasonic imaging. More generally, this matrix approach opens an original and powerful route for quantitative imaging in wave physics.

Published
2020
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4. Reflection Matrix Approach for Quantitative Imaging of Scattering Media

Author

Lambert, William, Cobus, Laura A., Couade, Mathieu, Fink, Mathias, Aubry, Alexandre, Institut Langevin - Ondes et Images, Université Paris Diderot - Paris 7 (UPD7)-ESPCI ParisTech-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut Langevin ondes et images, Centre National de la Recherche Scientifique (CNRS)-ESPCI ParisTech-Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC), SuperSonic Imagine, Supersonic Imagine, Institut Langevin - Ondes et Images (UMR7587) (IL), Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS), Supersonic Imagine-Supersonic Imagine, Thèse CIFRE de William Lambert financé par SuperSonic Imagine, European Project: 819261,REMINISCENCE, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Beamforming, QC1-999, FOS: Physical sciences, General Physics and Astronomy, Applied Physics (physics.app-ph), 01 natural sciences, 010305 fluids & plasmas, Speckle pattern, Matrix (mathematics), Transformation matrix, Optics, 0103 physical sciences, [PHYS.COND.CM-DS-NN]Physics [physics]/Condensed Matter [cond-mat]/Disordered Systems and Neural Networks [cond-mat.dis-nn], 010306 general physics, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Physics, Scattering, business.industry, Physics - Applied Physics, Characterization (materials science), Transducer, Physics - Data Analysis, Statistics and Probability, Ultrasonic sensor, business, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Data Analysis, Statistics and Probability (physics.data-an), [PHYS.PHYS.PHYS-DATA-AN]Physics [physics]/Physics [physics]/Data Analysis, Statistics and Probability [physics.data-an]
Abstract

We present a physically intuitive matrix approach for wave imaging and characterization in scattering media. The experimental proof-of-concept is performed with ultrasonic waves, but this approach can be applied to any field of wave physics for which multi-element technology is available. The concept is that focused beamforming enables the synthesis, in transmit and receive, of an array of virtual transducers which map the entire medium to be imaged. The inter-element responses of this virtual array form a focused reflection matrix from which spatial maps of various characteristics of the propagating wave can be retrieved. Here we demonstrate: (i) a local focusing criterion that enables the image quality and the wave velocity to be evaluated everywhere inside the medium, including in random speckle, and (ii) an highly resolved spatial mapping of the prevalence of multiple scattering, which constitutes a new and unique contrast for ultrasonic imaging. The approach is demonstrated for a controllable phantom system, and for in vivo imaging of the human abdomen. More generally, this matrix approach opens an original and powerful route for quantitative imaging in wave physics., Comment: 18 pages, 6 figures

Published
2020
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5. Distortion matrix approach for full-field imaging of random scattering media

Author

Lambert, William, Cobus, Laura, Frappart, Thomas, Fink, Mathias, Aubry, Alexandre, Institut Langevin - Ondes et Images (UMR7587) (IL), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Thèse CIFRE de William Lambert financée par SuperSonic Imagine, European Project: 819261,REMINISCENCE, Institut Langevin - Ondes et Images, Université Paris Diderot - Paris 7 (UPD7)-ESPCI ParisTech-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), SuperSonic Imagine, Supersonic Imagine, Institut Langevin ondes et images, Centre National de la Recherche Scientifique (CNRS)-ESPCI ParisTech-Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université Paris Diderot - Paris 7 (UPD7)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS)

Subjects
acoustic speckle, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], transmission matrix imaging, complex media, sample-induced aberrations, waves, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
Abstract

International audience; Focusing waves inside inhomogeneous media is a fundamental problem for imaging. Spatial variations of wave velocity can strongly distort propagating wavefronts and degrade image quality. Adaptive focusing can compensate for such aberration, but is only effective over a restricted field of view. Here, we introduce a full-field approach to wave imaging based on the concept of the distortion matrix. This operator essentially connects any focal point inside the medium with the distortion that a wavefront, emitted from that point, experiences due to heterogeneities. A time-reversal analysis of the distortion matrix enables the estimation of the transmission matrix that links each sensor and image voxel. Phase aberrations can then be unscrambled for any point, providing a full-field image of the medium with diffraction-limited resolution. Importantly, this process is particularly efficient in random scattering media, where traditional approaches such as adaptive focusing fail. Here, we present a proof of concept based on an ultrasound imaging experiment, but this approach can also be extended to optical microscopy, radar or seismic imaging.

Published
2020
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6. Ex vivo optimisation of a heterogeneous speed of sound model of the human skull for non-invasive transcranial focused ultrasound at 1 MHz

Author

Anne-Laure Boch, Dorian Chauvet, R. La Greca, Mickael Tanter, Jean-François Aubry, Kathia Chaumoitre, L. Marsac, Physique des ondes pour la médecine, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), SuperSonic Imagine, Supersonic Imagine, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Fondation Ophtalmologique Adolphe de Rothschild [Paris], Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Nord [CHU - APHM], Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), and Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS)

Subjects
Cancer Research, Physiology, medicine.medical_treatment, Acoustics, Models, Biological, 01 natural sciences, Focused ultrasound, 030218 nuclear medicine & medical imaging, modelling, thermal ablation, 03 medical and health sciences, Human skull, Ultrasonic grating, 0302 clinical medicine, Physiology (medical), Speed of sound, 0103 physical sciences, medicine, Humans, 010301 acoustics, ComputingMilieux_MISCELLANEOUS, Aged, 80 and over, Essential tremor, ultrasound, business.industry, Skull, Ultrasound, medicine.disease, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, High intensity focused ultrasound, High-intensity focused ultrasound, Sound, medicine.anatomical_structure, High-Intensity Focused Ultrasound Ablation, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Tomography, X-Ray Computed, business
Abstract

International audience; Transcranial brain therapy has recently emerged as a non-invasive strategy for the treatment of various neurological diseases, such as essential tremor or neurogenic pain. However, treatments require millimetre-scale accuracy. The use of high frequencies (typically ≥1 MHz) decreases the ultrasonic wavelength to the millimetre scale, thereby increasing the clinical accuracy and lowering the probability of cavitation, which improves the safety of the technique compared with the use of low-frequency devices that operate at 220 kHz. Nevertheless, the skull produces greater distortions of high-frequency waves relative to low-frequency waves. High-frequency waves require high-performance adaptive focusing techniques, based on modelling the wave propagation through the skull. This study sought to optimise the acoustical modelling of the skull based on computed tomography (CT) for a 1 MHz clinical brain therapy system. The best model tested in this article corresponded to a maximum speed of sound of 4000 m.s-1 in the skull bone, and it restored 86% of the optimal pressure amplitude on average in a collection of six human skulls. Compared with uncorrected focusing, the optimised non-invasive correction led to an average increase of 99% in the maximum pressure amplitude around the target and an average decrease of 48% in the distance between the peak pressure and the selected target. The attenuation through the skulls was also assessed within the bandwidth of the transducers, and it was found to vary in the range of 10 ± 3 dB at 800 kHz and 16 ± 3 dB at 1.3 MHz.

Published
2017
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7. Noninvasive In Vivo Liver Fibrosis Evaluation Using Supersonic Shear Imaging: A Clinical Study on 113 Hepatitis C Virus Patients

Author

Mathieu Couade, Bertrand Nalpas, Jeremy Bercoff, Stanislas Pol, Anne Badel, Anaïs Vallet-Pichard, Mathias Fink, Eric Bavu, Jean-Luc Gennisson, Vincent Mallet, Mickael Tanter, Institut Langevin - Ondes et Images (UMR7587) (IL), Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS), Physique des ondes pour la médecine, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), SuperSonic Imagine, Supersonic Imagine, Service d'hépatologie médicale [CHU Cochin], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Bioinformatique génomique et moléculaire ((U 726)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Institut Langevin - Ondes et Images, Université Paris Diderot - Paris 7 (UPD7)-ESPCI ParisTech-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP], and Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Acoustics and Ultrasonics, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Hepatitis C virus, Biophysics, medicine.disease_cause, Shear wave spectroscopy, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Elasticity Imaging Techniques, 0302 clinical medicine, Liver Function Tests, Fibrosis, Ultrasound, medicine, 2-D transient elastography, Humans, Radiology, Nuclear Medicine and imaging, Aged, Aged, 80 and over, Analysis of Variance, Radiological and Ultrasound Technology, medicine.diagnostic_test, Receiver operating characteristic, business.industry, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Hepatitis C, Hepatitis C, Chronic, Middle Aged, Image Enhancement, medicine.disease, Liver fibrosis staging, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], 3. Good health, ROC Curve, Area Under Curve, Shear wave imaging, Female, 030211 gastroenterology & hepatology, Elastography, Radiology, Nuclear medicine, business, Liver function tests
Abstract

International audience; Supersonic shear imaging (SSI) has recently been demonstrated to be a repeatable and reproducible transient bidimensional elastography technique. We report a prospective clinical evaluation of the performances of SSI for liver fibrosis evaluation in 113 patients with hepatitis C virus (HCV) and a comparison with FibroScan (FS). Liver elasticity values using SSI and FS ranged from 4.50 kPa to 33.96 kPa and from 2.60 kPa to 46.50 kPa, respectively. Analysis of variance (ANOVA) shows a good agreement between fibrosis staging and elasticity assessment using SSI and FS (p , 10 25). The areas under receiver operating characteristic (ROC) curves for elasticity values assessed from SSI were 0.948, 0.962 and 0.968 for patients with predicted fibrosis levels F $ 2, F $ 3 and F 5 4, respectively. These values are compared with FS area under the receiver operating characteristic curve (AUROC) of 0.846, 0.857 and 0.940, respectively. This comparison between ROC curves is particularly significant for mild and intermediate fibrosis levels. SSI appears to be a fast, simple and reliable method for noninvasive liver fibrosis evaluation.

Published
2011
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8. Random Calibration for Accelerating MR-ARFI Guided Ultrasonic Focusing in Transcranial Therapy

Author

Antoine Liutkus, Na Liu, Jean-François Aubry, Laurent Marsac, Mickael Tanter, Laurent Daudet, Institut Langevin - Ondes et Images (UMR7587) (IL), Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS), Analysis, perception and recognition of speech (PAROLE), Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Department of Natural Language Processing & Knowledge Discovery (LORIA - NLPKD), Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), SuperSonic Imagine, Supersonic Imagine, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Computer science, Acoustics, Ultrasonic Therapy, Transducers, Focused ultrasound, Optics, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Distortion, medicine, Calibration, Humans, Radiology, Nuclear Medicine and imaging, Brain Diseases, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Phantoms, Imaging, Ultrasound, Skull, Process (computing), Magnetic resonance imaging, Magnetic Resonance Imaging, Radiography, medicine.anatomical_structure, Transducer, High-Intensity Focused Ultrasound Ablation, Ultrasonic sensor, business
Abstract

International audience; Transcranial focused ultrasound is a promising therapeutic modality. It consists in placing transducers around the skull and emitting shaped ultrasound waves that propagate through the skull and then concentrate on one particular location within the brain. However, the skull bone is known to distort the ultrasound beam. In order to compensate for such distortions, a number of techniques have been proposed recently, for instance using Magnetic Resonance Imaging (MRI) feedback. In order to fully determine the focusing distortion due to the skull, such methods usually require as many calibration signals as transducers, resulting in a lengthy calibration process. In this paper, we investigate how the number of calibration sequences can be signicantly reduced, based on random measurements and optimization techniques. Experimental data with six human skulls demonstrate that the number of measurements can be up to three times lower than with the standard methods, while restoring 90% of the focusing eciency.

Published
2015
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9. Three-Dimensional Ultrasound Matrix Imaging

Author

Bureau, Flavien, Robin, Justine, Ber, Arthur Le, Lambert, William, Fink, Mathias, Aubry, Alexandre, Institut Langevin - Ondes et Images (UMR7587) (IL), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Physique pour la médecine (PhysMed Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hologic-Supersonic Imagine, Aix-en-Provence, and European Project: 819261,REMINISCENCE

Subjects
[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], Image and Video Processing (eess.IV), FOS: Electrical engineering, electronic engineering, information engineering, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], FOS: Physical sciences, Applied Physics (physics.app-ph), Medical Physics (physics.med-ph), Physics - Applied Physics, Electrical Engineering and Systems Science - Image and Video Processing, Physics - Medical Physics
Abstract

Matrix imaging paves the way towards a next revolution in wave physics. Based on the response matrix recorded between a set of sensors, it enables an optimized compensation of aberration phenomena and multiple scattering events that usually drastically hinder the focusing process in heterogeneous media. Although it gave rise to spectacular results in optical microscopy or seismic imaging, the success of matrix imaging has been so far relatively limited with ultrasonic waves because wave control is generally only performed with a linear array of transducers. In this paper, we extend ultrasound matrix imaging to a 3D geometry. Switching from a 1D to a 2D probe enables a much sharper estimation of the transmission matrix that links each transducer and each medium voxel. Here, we first present an experimental proof of concept on a tissue-mimicking phantom through ex-vivo tissues and then, show the potential of 3D matrix imaging for transcranial applications., 52 pages, 13 figures

Published
2023

10. Muscle shear elastic modulus is linearly related to muscle torque over the entire range of isometric contraction intensity

Author

Jeremy Bercoff, Killian Bouillard, François Hug, Mathieu Couade, Antoine Nordez, Filiz Ateş, Marc Jubeau, Thomas Frappart, Motricité, interactions, performance EA 4334 / Movement - Interactions - Performance (MIP), Université de Nantes - UFR des Sciences et Techniques des Activités Physiques et Sportives (UFR STAPS), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Le Mans Université (UM), The University of Queensland, NHMRC Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, School of Health and Rehabilitation Sciences, Brisbane, Australia., University of Queensland [Brisbane], SuperSonic Imagine, Supersonic Imagine, and Supersonic Imagine-Supersonic Imagine

Subjects
Ultrasound elastography, Adult, Male, Coefficient of determination, Materials science, Ergometry, Supersonic shear imaging, Biophysics, Neuroscience (miscellaneous), Isometric exercise, Shear modulus, Fingers, 03 medical and health sciences, 0302 clinical medicine, Optics, Region of interest, Abductor Digiti Minimi, Elastic Modulus, Isometric Contraction, Linear regression, [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Torque, Humans, Muscle, Skeletal, Elastic modulus, Force, business.industry, 030229 sport sciences, musculoskeletal system, Intensity (physics), Shear wave, Elasticity Imaging Techniques, Neurology (clinical), business, 030217 neurology & neurosurgery, Biomedical engineering
Abstract

International audience; Muscle shear elastic modulus is linearly related to muscle torque during low-level contractions (

Published
2014
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11. Ultrasound Matrix Imaging—Part I: The focused reflection matrix, the F-factor and the role of multiple scattering

Author

William Lambert, Justine Robin, Laura A. Cobus, Mathias Fink, Alexandre Aubry, Institut Langevin - Ondes et Images (UMR7587) (IL), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Physique pour la médecine (PhysMed Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), PhD thesis of William Lambert funded by the SuperSonic Imagine company, ANR-10-LABX-0024,WIFI,Institut Langevin : Ondes et Images, du Fondamental à l'Innovation(2010), European Project: 819261,REMINISCENCE, European Project: 744840,SMART, and Physique pour la médecine (UMR 8063, U1273)

Subjects
Ultrasound Matrix Imaging, Transducers, FOS: Physical sciences, Applied Physics (physics.app-ph), FOS: Electrical engineering, electronic engineering, information engineering, Humans, Electrical and Electronic Engineering, Ultrasonography, Coherence Factor, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Radiological and Ultrasound Technology, Phantoms, Imaging, Image and Video Processing (eess.IV), Physics - Applied Physics, Electrical Engineering and Systems Science - Image and Video Processing, Physics - Medical Physics, Focusing Factor, Computer Science Applications, Multiple scattering, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Medical Physics (physics.med-ph), Noise, Aberration, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Software, [PHYS.PHYS.PHYS-DATA-AN]Physics [physics]/Physics [physics]/Data Analysis, Statistics and Probability [physics.data-an]
Abstract

This is the first article in a series of two dealing with a matrix approach for aberration quantification and correction in ultrasound imaging. Advanced synthetic beamforming relies on a double focusing operation at transmission and reception on each point of the medium. Ultrasound matrix imaging (UMI) consists in decoupling the location of these transmitted and received focal spots. The response between those virtual transducers form the so-called focused reflection matrix that actually contains much more information than a confocal ultrasound image. In this paper, a time-frequency analysis of this matrix is performed, which highlights the single and multiple scattering contributions as well as the impact of aberrations in the monochromatic and broadband regimes. Interestingly, this analysis enables the measurement of the incoherent input-output point spread function at any pixel of this image. A fitting process enables the quantification of the single scattering, multiple scattering and noise components in the image. From the single scattering contribution, a focusing criterion is defined, and its evolution used to quantify the amount of aberration throughout the ultrasound image. In contrast to the state-of-the-art coherence factor, this new indicator is robust to multiple scattering and electronic noise, thereby providing a contrasted map of the focusing quality at a much better transverse resolution. After a validation of the proof-of-concept based on time-domain simulations, UMI is applied to the in-vivo study of a human calf. Beyond this specific example, UMI opens a new route for speed-of-sound and scattering quantification in ultrasound imaging., 15 pages, 7 figures

Published
2022
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12. Quantitative assessment of myocardial viscoelastic properties using shear wave imaging

Author

Pernot, Mathieu, Couade, Mathieu, Lee, Wei-Ning, Fink, Mathias, Tanter, Mickaël, Physique des ondes pour la médecine, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Langevin - Ondes et Images (UMR7587) (IL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), SuperSonic Imagine, Supersonic Imagine, Supersonic Imagine-Supersonic Imagine, Société Française d'Acoustique, Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], stiffness, ultrasound, Quantitative Biology::Tissues and Organs, Myocardium, Physics::Medical Physics, shear wave
Abstract

International audience; Cardiac pathologies are often characterized by a significant change of myocardial stiffness, re-organization of muscle fiber structure, and the accompanying dysfunction, all of which remain challenging to be quantitatively assessed in vivo. The approach developed in this work is based on Shear Wave Imaging (SWI) a technique developed at the Langevin institute that provides real-time mapping of soft tissues viscoelastic properties. The technique relies on two successive steps: first, a shear wave is remotely induced in the myocardium using the acoustic radiation force of a focused beam, and second, the shear wave propagation is imaged using ultrafast imaging (10,000 frames per seconds). The shear modulus is derived from the shear wave speed. SWI is applied to the evaluation of myocardial stiffness on animal models of cardiomyopathy. The dynamics of change in shear modulus during the cardiac cycle is measured and the relationship between the viscoelastic properties and physiological parameters such as contractility or pathologies such as infarction is investigated. Finally, an imaging technique of the myocardial fiber orientation is developed by exploiting the anisotropy of shear wave propagation. This technique can map the complex distribution of muscle fibers in the myocardium and is compared to MR diffusion tensor imaging.

Published
2012

13. MR-guided adaptive focusing of therapeutic ultrasound beams in the human head

Author

L, Marsac, D, Chauvet, B, Larrat, M, Pernot, B, Robert, M, Fink, A L, Boch, J F, Aubry, M, Tanter, Physique des ondes pour la médecine, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Langevin - Ondes et Images (UMR7587) (IL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), SuperSonic Imagine, Supersonic Imagine, Supersonic Imagine-Supersonic Imagine, Service de Neurochirurgie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Marsac, Laurent, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
ultrasound transcranial therapy, [SDV.IB] Life Sciences [q-bio]/Bioengineering, Brain, adaptive focusing, HIFU, MR-ARFI, Magnetic Resonance Imaging, Interventional, Article, Treatment Outcome, Surgery, Computer-Assisted, Animals, Feasibility Studies, High-Intensity Focused Ultrasound Ablation, Humans, Cattle, [SDV.IB]Life Sciences [q-bio]/Bioengineering, MRI
Abstract

International audience; Purpose: This study aims to demonstrate, using human cadavers the feasibility of energy-based adaptive focusing of ultrasonic waves using magnetic resonance acoustic radiation force imaging (MR-ARFI) in the framework of non-invasive transcranial high intensity focused ultrasound (HIFU) therapy.Methods: Energy-based adaptive focusing techniques were recently proposed in order to achieve aberration correction. The authors evaluate this method on a clinical brain HIFU system composed of 512 ultrasonic elements positioned inside a full body 1.5 T clinical magnetic resonance (MR) imaging system. Cadaver heads were mounted onto a clinical Leksell stereotactic frame. The ultrasonic wave intensity at the chosen location was indirectly estimated by the MR system measuring the local tissue displacement induced by the acoustic radiation force of the ultrasound (US) beams. For aberration correction, a set of spatially encoded ultrasonic waves was transmitted from the ultrasonic array and the resulting local displacements were estimated with the MR-ARFI sequence for each emitted beam. A noniterative inversion process was then performed in order to estimate the spatial phase aberrations induced by the cadaver skull. The procedure was first evaluated and optimized in a calf brain using a numerical aberrator mimicking human skull aberrations. The full method was then demonstrated using a fresh human cadaver head.Results: The corrected beam resulting from the direct inversion process was found to focus at the targeted location with an acoustic intensity 2.2 times higher than the conventional non corrected beam. In addition, this corrected beam was found to give an acoustic intensity 1.5 times higher than the focusing pattern obtained with an aberration correction using transcranial acoustic simulation-based on X-ray computed tomography (CT) scans.Conclusions: The proposed technique achieved near optimal focusing in an intact human head for the first time. These findings confirm the strong potential of energy-based adaptive focusing of transcranial ultrasonic beams for clinical applications.

Published
2012
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14. Real-Time Assessment of Myocardial Contractility Using Shear Wave Imaging

Author

Bertrand Crozatier, Mathieu Pernot, Mathieu Couade, Rodolphe Fischmeister, Mickael Tanter, Philippe Mateo, Physique des ondes pour la médecine, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Langevin - Ondes et Images (UMR7587) (IL), Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS), SuperSonic Imagine, Supersonic Imagine, Supersonic Imagine-Supersonic Imagine, IFR141, Faculté de Pharmacie, Université Paris-Sud 11, Institut Paris-Sud d'Innovation Thérapeutique, Signalisation et physiopathologie cardiovasculaire (UMRS1180), and Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
musculoskeletal diseases, medicine.medical_specialty, Time Factors, animal structures, Systole, Heart Ventricles, genetic processes, Myocardial stiffness, macromolecular substances, 030204 cardiovascular system & hematology, contractility, Shear wave imaging, 030218 nuclear medicine & medical imaging, Contractility, 03 medical and health sciences, Elasticity Imaging Techniques, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, Receptors, Adrenergic, beta, Pressure, myocardium, medicine, Animals, Humans, echocardiography, Peak systolic pressure, business.industry, Isoproterenol, technology, industry, and agriculture, imaging, Myocardium metabolism, Heart, equipment and supplies, Myocardial Contraction, Rats, enzymes and coenzymes (carbohydrates), Cardiology, Regression Analysis, Calcium, elasticity, Stress, Mechanical, biological phenomena, cell phenomena, and immunity, Cardiology and Cardiovascular Medicine, business
Abstract

ObjectivesThe goal of this study was to assess whether myocardial stiffness could be measured by shear wave imaging (SWI) and whether myocardial stiffness accurately quantified myocardial function.BackgroundSWI is a novel ultrasound-based technique for quantitative, local, and noninvasive mapping of soft tissue elastic properties.MethodsSWI was performed in Langendorff perfused isolated rat hearts (n = 6). Shear wave was generated and imaged in the left ventricular myocardium using a conventional ultrasonic probe connected to an ultrafast scanner (12,000 frames/s). The local myocardial stiffness was derived from shear wave velocity every 7.5 ms during 1 single cardiac cycle.ResultsThe average myocardial stiffness was 8.6 ± 0.7 kPa in systole and 1.7 ± 0.8 kPa in diastole. Myocardial stiffness was compared with isovolumic systolic pressure at rest and during administration of isoproterenol (10−9, 10−8, and 10−7 mol/l, 5 min each). Systolic myocardial stiffness increased strongly up to 23.4 ± 3.4 kPa. Myocardial stiffness correlated strongly with isovolumic systolic pressure (r2 = [0.94; 0.98], p < 0.0001).ConclusionsMyocardial stiffness can be measured in real time over the cardiac cycle using SWI, which allows quantification of stiffness variation between systole and diastole. Systolic myocardial stiffness provides a noninvasive index of myocardial contractility.

Published
2011
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15. Smooth contour coding with minimal description length active grid segmentation techniques

Author

Frédéric Galland, Arnaud Jaegler, Philippe Réfrégier, Marc Allain, David Savery, PhyTI (PhyTI), Institut FRESNEL (FRESNEL), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Coherent Optical Microscopy and X-rays (COMiX), SuperSonic Imagine, Supersonic Imagine, Supersonic Imagine-Supersonic Imagine, Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), and Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)

Subjects
Large class, 0211 other engineering and technologies, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Scale-space segmentation, Image processing, 02 engineering and technology, Image segmentation, Grid, 3. Good health, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Artificial Intelligence, Signal Processing, 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, Segmentation, Computer Vision and Pattern Recognition, Minimum description length, Algorithm, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Software, 021101 geological & geomatics engineering, Mathematics, Coding (social sciences)
Abstract

International audience; We analyze the influence of the contour coding term in segmentation techniques based on active grids and on the minimum description length (MDL) principle. These segmentation techniques have been developed up to now with a contour coding term adapted to polygonal objects. However, this approach can lead to degraded segmentation results for smooth contours of objects which can be observed for example in geoscience, medicine or microscopy. We demonstrate that an appropriate choice of the contour coding term can improve segmentation results with MDL active grid approaches in the presence of regions with smooth boundaries. This improvement opens a large class of application domains and still allows one to obtain low computational time.

Published
2011
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16. Ultrasound Matrix Imaging-Part II: The Distortion Matrix for Aberration Correction Over Multiple Isoplanatic Patches

Author

William Lambert, Laura A. Cobus, Justine Robin, Mathias Fink, Alexandre Aubry, Institut Langevin - Ondes et Images (UMR7587) (IL), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Physique pour la médecine (PhysMed Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), PhD thesis of William Lambert funded by the SuperSonic Imagine Company, ANR-10-IDEX-0001,PSL,Paris Sciences et Lettres(2010), European Project: 819261,REMINISCENCE, European Project: 744840,SMART, Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS), and Physique pour la médecine (UMR 8063, U1273)

Subjects
[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Radiological and Ultrasound Technology, Ultrasound Matrix Imaging, Phantoms, Imaging, Image and Video Processing (eess.IV), Transducers, FOS: Physical sciences, Applied Physics (physics.app-ph), Physics - Applied Physics, Acoustics, Electrical Engineering and Systems Science - Image and Video Processing, Physics - Medical Physics, Computer Science Applications, FOS: Electrical engineering, electronic engineering, information engineering, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Aberration Correction, Medical Physics (physics.med-ph), Electrical and Electronic Engineering, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Software, Distortion Matrix, Computational Ultrasound, [PHYS.PHYS.PHYS-DATA-AN]Physics [physics]/Physics [physics]/Data Analysis, Statistics and Probability [physics.data-an], Ultrasonography
Abstract

This is the second article in a series of two which report on a matrix approach for ultrasound imaging in heterogeneous media. This article describes the quantification and correction of aberration, i.e. the distortion of an image caused by spatial variations in the medium speed-of-sound. Adaptive focusing can compensate for aberration, but is only effective over a restricted area called the isoplanatic patch. Here, we use an experimentally-recorded matrix of reflected acoustic signals tosynthesize a set of virtual transducers. We then examine wave propagation between these virtual transducers and an arbitrary correction plane. Such wave-fronts consist of two components: (i) An ideal geometric wave-front linked to diffraction and the input focusing point, and; (ii) Phase distortions induced by the speed-of-sound variations. These distortions are stored in a so-called distortion matrix, the singular value decomposition of which gives access to an optimized focusing law at any point. We show that, by decoupling the aberrations undergone by the outgoing and incoming waves and applying an iterative strategy, compensation for even high-order and spatially-distributed aberrations can be achieved. After a numerical validation of the process, ultrasound matrix imaging (UMI) is applied to the in-vivo imaging of a gallbladder. A map of isoplanatic modes is retrieved and is shown to be strongly correlated with the arrangement of tissues constituting the medium. The corresponding focusing laws yield an ultrasound image with drastically improved contrast and transverse resolution. UMI thus provides a flexible and powerful route towards computational ultrasound., 20 pages, 11 figures

Published
2022
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17. Supersonic shear imaging is a new potent morphological non-invasive technique to assess of liver fibrosis. Part 2 : comparison with fibroscan

Author

Eric Bavu, Jean-Luc Gennisson, Vincent Mallet, Bruno-Félix Osmanski, Mathieu Couade, Jeremy Bercoff, Mathias Fink, Philippe Sogni, Anaïs Vallet-Pichard, Bertrand Nalpas, Tanter Mickael, Stanislas Pol, Laboratoire de Mécanique des Structures et des Systèmes Couplés (LMSSC), Conservatoire National des Arts et Métiers [CNAM] (CNAM), Laboratoire ondes et acoustique (LOA), Université Paris Diderot - Paris 7 (UPD7)-ESPCI ParisTech-Centre National de la Recherche Scientifique (CNRS), Département d'hépatologie [CHU Cochin], CHU Cochin [AP-HP]-Institut National de la Santé et de la Recherche Médicale (INSERM), Supersonic Imagine, SuperSonic Imagine, Institut Langevin ondes et images, Centre National de la Recherche Scientifique (CNRS)-ESPCI ParisTech-Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC), Service d'hépatologie médicale [CHU Cochin], CHU Cochin [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), BAVU, Eric, Physique des ondes pour la médecine, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Langevin - Ondes et Images (UMR7587) (IL), Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Hôpital Cochin [AP-HP]

Subjects
[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2010

18. A new potent morphological non-invasive technique to assess liver Fibrosis : Part I, Technical feasibility

Author

Eric Bavu, Jean-Luc Gennisson, Vincent Mallet, Bruno-Félix Osmanski, Mathieu Couade, Jeremy Bercoff, Mathias Fink, Philippe Sogni, Anaïs Vallet-Pichard, Bertrand Nalpas, Tanter Mickael, Stanislas Pol, Laboratoire de Mécanique des Structures et des Systèmes Couplés (LMSSC), Conservatoire National des Arts et Métiers [CNAM] (CNAM), Laboratoire ondes et acoustique (LOA), Université Paris Diderot - Paris 7 (UPD7)-ESPCI ParisTech-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Institut Cochin (UMR_S567 / UMR 8104), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Auteur indépendant, Institut Langevin ondes et images, Centre National de la Recherche Scientifique (CNRS)-ESPCI ParisTech-Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC), Physique des ondes pour la médecine, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Langevin - Ondes et Images (UMR7587) (IL), Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), SuperSonic Imagine, Supersonic Imagine, Supersonic Imagine-Supersonic Imagine, and BAVU, Eric

Subjects
[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2010

19. Quantification non-invasive du degré de Fibrose Hépatique par Élastographie Dynamique (Supersonic Shear Imaging)

Author

Eric Bavu, Jean-Luc Gennisson, Bruno-Félix Osmanski, Mathieu Couade, Jérémy Bercoff, Vincent Mallet, Mathias Fink, Philippe Sogni, Anaïs Vallet-Pichard, Bertrand Nalpas, Mickael Tanter, Stanislas Pol, Laboratoire de Mécanique des Structures et des Systèmes Couplés (LMSSC), Conservatoire National des Arts et Métiers [CNAM] (CNAM), Institut Langevin - Ondes et Images (UMR7587) (IL), Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS), Physique des ondes pour la médecine, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), SuperSonic Imagine, Supersonic Imagine, Supersonic Imagine-Supersonic Imagine, Département d'hépatologie [CHU Cochin], Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Société Française d'Acoustique - SFA, Centre d'enseignement Cnam Paris ( CNAM Paris ), Conservatoire National des Arts et Métiers [CNAM] ( CNAM ), Laboratoire ondes et acoustique ( LOA ), Université Paris Diderot - Paris 7 ( UPD7 ) -ESPCI ParisTech-Centre National de la Recherche Scientifique ( CNRS ), Institut Pasteur [Paris]-CHU Cochin [AP-HP]-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut Langevin ondes et images, Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Diderot - Paris 7 ( UPD7 ) -ESPCI ParisTech-Centre National de la Recherche Scientifique ( CNRS ), Leclere, Quentin, HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Hôpital Cochin [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [ SPI.ACOU ] Engineering Sciences [physics]/Acoustics [physics.class-ph], SSI, Fibrose, Élastographie transitoire, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Foie, [ PHYS.MECA.ACOU ] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract

National audience; Il a été récemment démontré que l’élastographie par pression de radiation (Supersonic Shear Imaging - SSI) est capable de quantifier les propriétés viscoélastiques du foie chez l’homme. Cette technique développée à l’institut Langevin a démontré sa bonne reproductibilité, répétabilité et son indépendance vis à vis de la respiration du sujet. La technique SSI est basée sur l’utilisation in vivo de la pression de radiation ultrasonore, qui permet d'induire une onde de cisaillement profondément dans les tissus. La propagation de cette onde est alors imagée grâce à un échographe ultrarapide (5000 images/secondes). L’estimation de la vitesse de l’onde en fonction de la fréquence donne alors accès aux paramètres viscoélastiques des tissus. Cette étude a permis de construire de solides bases pour élaborer un protocole clinique de qualité. Dans le travail qui suit, la technique SSI, adaptée à une sonde courbe (C42 – 2.5 MHz), est utilisée pour cartographier entre les côtes les propriétés viscoélastiques de 142 patients atteints de maladies hépatiques chroniques (VHC, VHB, cirrhose connue). Sur ces mêmes patients un examen Fibroscan (élastographie transitoire monodimensionelle) ainsi qu’une prise de sang sont réalisés. Cette dernière permettant de déterminer le niveau de fibrose des patients et leur score METAVIR (Fib4, FORN’s, APRI). Les paramètres viscoélastiques du foie sont déterminés sur une large bande fréquentielle et cartographiés sur une surface de 120x75 mm². Cette étude montre que la technique SSI permet de discriminer de manière quantitative et avec une bonne différentiation les niveaux de fibrose des patients (p-index ~=.10-16 ). La technique permet de s'affranchir des problèmes d'hétérogénéités affectant les techniques d'élastographie 1D. Cette étude suggère ainsi que la technique SSI pourrait devenir un examen de routine complémentaire précis et fiable pour la détermination du niveau de fibrose hépatique et permettrait de diagnostiquer plus rapidement les pathologies hépatiques chroniques.

Published
2010

20. Modes de propagations guidés en plaques minces: Application à lélastographie haute-résolution de la cornée et de la peau par Supersonic Shear Imagine

Author

Thu-Mai Nguyen, jean-luc gennisson, David Touboul, Jérémy Bercoff, Mathias Fink, Mickael Tanter, Physique des ondes pour la médecine, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Langevin - Ondes et Images (UMR7587) (IL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, SuperSonic Imagine, Supersonic Imagine, Supersonic Imagine-Supersonic Imagine, Société Française d'Acoustique - SFA, Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], peau, cornée, élastographie haute-résolution, ondes guidées, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract

National audience; La caractérisation des propriétés viscoélastiques de la cornée et de la peau a de nombreuses applications en ophtalmologie et en dermatologie, telles que la compréhension et le diagnostique des pathologies ou encore l’évaluation et le suivi des traitements. L’élastographie dynamique haute résolution (15 MHz) semble être un outil pertinent pour répondre à ces questions. Dans le travail qui suit, la méthode d’élastographie par onde de cisaillement est utilisée (Supersonic Shear Imaging - SSI). Cette méthode basée sur la combinaison d’un échographe ultrarapide (10000 images/s) et de la pression de radiation ultrasonore, permet de générer et de suivre la propagation d’ondes de cisaillement hautes fréquences (de 500 à 3000 Hz) dans les tissus. La vitesse de ces dernières est directement corrélée à l’élasticité du milieu. Les milieux étudiés constituent des plaques d’épaisseur submillimétrique. La propagation de l’onde de cisaillement est alors guidée par des plaques d’épaisseur comparable à sa longueur d’onde. L’objectif de ce travail est d’établir les relations de dispersion dans des plaques planes infinies entourées par un solide élastique d’une part (peau), à courbure sphérique entourées de liquides d’autre part (cornée). Une étude numérique a été effectuée pour établir les relations de dispersion théoriques. Ce travail montre que la prise en compte de la dispersion des ondes guidées permet de traiter le problème inverse de l’élastographie dans le cas de milieux stratifiés d’épaisseur faible devant la longueur d’onde de cisaillement. Les résultats théoriques sont comparés aux relations de dispersion expérimentales et sont utilisés pour obtenir des cartes d’élasticité quantitatives sur la peau de volontaires sains (différenciation des couches élastiques de la peau : épiderme, derme, hypoderme.) et sur des yeux de porc ex vivo (détermination de la pression intraoculaire par la mesure de l’élasticité de la cornée, évaluation de l’efficacité du cross-linking par UVA).

Published
2010

21. Transcranial ultrasonic therapy based on time reversal of acoustically induced cavitation bubble signature

Author

Laurent Marsac, Jérôme Gateau, Mathias Fink, Mickael Tanter, Jean-François Aubry, Mathieu Pernot, Physique des ondes pour la médecine, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Langevin - Ondes et Images (UMR7587) (IL), Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS), Supersonic imagine, Supersonic Imagine, Gateau, Jérôme, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
MESH: Subtraction Technique, Ultrasonography, Doppler, Transcranial, Bubble, Acoustics, Ultrasonic Therapy, Beam steering, Biomedical Engineering, MESH: Algorithms, MESH: Signal Processing, Computer-Assisted, 01 natural sciences, Signal, Article, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, MESH: Computer Simulation, 0103 physical sciences, Pressure, Humans, Computer Simulation, Sound pressure, 010301 acoustics, [SDV.IB] Life Sciences [q-bio]/Bioengineering, Physics, MESH: Humans, Microbubbles, Hydrophone, Phantoms, Imaging, Skull, MESH: Ultrasonography, Doppler, Transcranial, Signal Processing, Computer-Assisted, MESH: Ultrasonic Therapy, MESH: Phantoms, Imaging, Cavitation, Subtraction Technique, Ultrasonic sensor, MESH: Skull, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Focus (optics), MESH: Pressure, MESH: Microbubbles, Algorithms
Abstract

International audience; Brain treatment through the skull with high-intensity focused ultrasound can be achieved with multichannel arrays and adaptive focusing techniques such as time reversal. This method requires a reference signal to be either emitted by a real source embedded in brain tissues or computed from a virtual source, using the acoustic properties of the skull derived from computed tomography images. This noninvasive computational method focuses with precision, but suffers from modeling and repositioning errors that reduce the accessible acoustic pressure at the focus in comparison with fully experimental time reversal using an implanted hydrophone. In this paper, this simulation-based targeting has been used experimentally as a first step for focusing through an ex vivo human skull at a single location. It has enabled the creation of a cavitation bubble at focus that spontaneously emitted an ultrasonic wave received by the array. This active source signal has allowed 97 +/- 1.1% of the reference pressure (hydrophone-based) to be restored at the geometrical focus. To target points around the focus with an optimal pressure level, conventional electronic steering from the initial focus has been combined with bubble generation. Thanks to step-by-step bubble generation, the electronic steering capabilities of the array through the skull were improved.

Published
2009
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22. Liver fibrosis staging using supersonic shear imaging : a clinical study on 142 patients

Author

Bavu, Eric, Gennisson, Jean-Luc, Osmanski, Bruno-Félix, BERCOFF, Jeremy, Fink, Mathias, Mallet, Vincent, Sogni, Philippe, Vallet-Pichard, Anaïs, Nalpas, Bertrand, Tanter, Mickael, Pol, Stanislas, BAVU, Eric, Institut Langevin - Ondes et Images, Université Paris Diderot - Paris 7 (UPD7)-ESPCI ParisTech-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Supersonic Imagine, SuperSonic Imagine, Département d'hépatologie [CHU Cochin], CHU Cochin [AP-HP]-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hépatologie médicale [CHU Cochin], CHU Cochin [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Institut Langevin ondes et images, Centre National de la Recherche Scientifique (CNRS)-ESPCI ParisTech-Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Langevin - Ondes et Images (UMR7587) (IL), Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Hôpital Cochin [AP-HP]

Subjects
[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Abstract

International audience; I. Background, Motivation and ObjectiveFibrosis staging can be assessed by a rough estimation of the liver stiffness averaged along an ultrasonic A-line. Providing a complete 2D map of liver stiffness would thus be of great clinical interest for the diagnosis of hepatic fibrosis and help prevent upcoming cirrhosis. However, such measurement requires both a quantitative value of shear elasticity and a great precision to discriminate between different fibrosis levels. Beyond the scope of non-invasive fibrosis quantification, it is also envisioned that quantitative elasticity imaging of liver will have potential interest for liver cancer diagnosis. In this work, the Supersonic Shear Imaging technique (SSI) is proposed to map the in vivo viscoelastic parameters of liver on patients with hepatitis C and derive a mean elasticity of liver tissues. The results are compared to biological tests (Fib4, Apri, Forns) and Fibroscan® measurements. II. Statement of Contribution / MethodsThe SSI technique is based on the radiation force induced by a conventional ultrasonic probe to generate a planar shear wave deep into tissues. The shear wave propagation throughout the medium is caught in real time thanks to an ultrafast ultrasound scanner (up to 5000 frames/s). Using modified sequences and post-processing, this technique is implemented on curved arrays in order to get a larger field of view of liver tissues. A study on 150 HCV patients with different fibrosis stages F has been conducted in order to investigate the accuracy of the technique (F ϵ [0;4]). Quantitative maps of liver elasticity are produced for each volunteer with a linear and a curved array. III. ResultsB-mode images of 120x75 mm² and corresponding elasticity maps are obtained using a 2.5 MHz curved ultrasonic probe with a good reproducibility and accuracy. The shear wave phase velocity dispersion is also calculated. This study shows a good correlation between the values obtained by SSI and the fibrosis levels diagnosed by biological tests (p-index < 10-8) and allows a good differentiation of fibrosis level F (Youden's index Y> 0.9 for F>3 and Y> 0.8 for F>2). Results are also compared (r2 > 0.92) to the Fibroscan® elasticity measurement by fitting the velocity dispersion curves obtained by SSI at 50 Hz.IV. Discussion and ConclusionsThis real-time elasticity mapping using an ultrasonic curved probe offers better signal to noise ratio than linear arrays and a larger area in the patient's liver (13.3±2.8 cm² estimation area). This gives more confidence on the accuracy of the diagnosis of the fibrosis stage. Furthermore, the elasticity parameters obtained with SSI give access to the shear wave group velocity and the phase velocity. As a consequence, the SSI assessment of liver stiffness could potentially give more information on the viscoelasticity properties of the liver.

Published
2009

23. ShearWave TM Elastography A new real time imaging mode for assessing quantitatively soft tissue viscoelasticity

Author

Bercoff, J, Criton, A, Bacrie, C, Souquet, J, Tanter, M, Gennisson, Jean, Deffieux, T, Fink, M, Juhan, Valerie, Colavolpe, Anne, Amy, Dominique, Athanasiou, Alexandra, SuperSonic Imagine, Supersonic Imagine, Supersonic Imagine-Supersonic Imagine, Laboratoire Ondes et Acoustique (UMR 7587) (LOA), Université Paris Diderot - Paris 7 (UPD7)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Unité BioMaps (BIOMAPS), Service Hospitalier Frédéric Joliot (SHFJ), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital de la Timone [CHU - APHM] (TIMONE), IEEE, LaBoratoire d'Imagerie biOmédicale MultimodAle Paris-Saclay (BIOMAPS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
supersonic, elastography, transient, quantitative, kPa, viscosity, elasticity, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Mach cone, shear wave
Abstract

International audience; ShearWave TM Elastography (SWE) is a new real time ultrasound imaging mode that quantitatively measures local tissue elasticity in kPa. Based on the Supersonic Shear Imaging concept (developped at the Laboratoire Ondes et Acoustique, Paris), this new concept may appear as a promising tool to improve breast lesion characterization. In vitro experimental measurements have been performed to quantify SWE mode performances in terms of resolution, penetration and the ability to measure quantitatively elasticity. Results show that the SWE mode exhibits a millimetric resolution and quantifies properly tissue elasticity on a wide range of elastic contrasts (from 7 to 110 kPa). The real time capabilities and the robustness of the mode have been tested in clinical conditions, on breast lesions. 150 patients have been scanned with SWE mode in three different sites. Results show that SWE performs well on breast pathologies and presents a very good inter-site reproducibility. Finally, the quantitative elasticity value was analyzed as a function of pathology using FNA or core biopsy as the reference diagnostic method.

Published
2008
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24. Exploring regional irrigation water demand using typologies of farms and production units : an example from Tunisia

Author

A. Imache, A. Benmihoub, Jean-Christophe Poussin, P. Le Grusse, R. Beji, Supersonic imagine, Supersonic Imagine, Commissariat Régional au Développement Agricole, Ministère de l'agriculture, and Dynamique sociétés-environnements sur le temps long en Afrique périsaharienne

Subjects
Farmers' choices, [SDE.MCG]Environmental Sciences/Global Changes, IRRIGATION GOUTTE A GOUTTE, [SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy, 0207 environmental engineering, Soil Science, REGIONAL WATER DEMAND, 02 engineering and technology, Irrigation water, Regional water demand, Farming system, FARMERS' CHOICES, MODELING, GESTION DE L'EAU,MODELISATION,EAU D'IRRIGATION,AGRICULTEUR,IRRIGATION GOUTTE A GOUTTE,DEMANDE EN EAU,REGIONAL WATER DEMAND,FARMERS' CHOICES,FARMING SYSTEM,MODELING, [SDV.SA.STA]Life Sciences [q-bio]/Agricultural sciences/Sciences and technics of agriculture, Political science, [SDU.STU.HY]Sciences of the Universe [physics]/Earth Sciences/Hydrology, 020701 environmental engineering, Earth-Surface Processes, Water Science and Technology, GESTION DE L'EAU, Environmental engineering, Modeling, AGRICULTEUR, Forestry, 04 agricultural and veterinary sciences, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, MODELISATION, FARMING SYSTEM, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, EAU D'IRRIGATION, [SDE]Environmental Sciences, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, DEMANDE EN EAU, Agronomy and Crop Science
Abstract

La plupart des méthodes utilisées pour prédire la consommation d'eau d'irrigation à l'échelle régionale sont fondées sur des modèles biophysiques et les assolements. Leur objectif est de fournir des estimations précises de la "demande d'eau" qui sont utiles pour la gestion des ressources en eau. Toutefois, dans le cas du libre accès à la ressource en eau, par exemple le pompage dans une nappe phréatique, il est seulement possible d'éviter la surexploitation au travers d'une "gestion" de la demande de l'eau basée sur les choix des agriculteurs et leurs comportement. Dans ce papier, nous proposons un cadre d'analyse pour représenter les activités agricoles en utilisant des typologies des exploitations agricoles et des unités de production agrégées à l'échelle régionale. Ce cadre peut être utilisé pour estimer la consommation d'eau d'irrigation et d'autres intrants, ainsi que la production agricole. Ce cadre peut également être utilisé pour évaluer les effets d'une technique, d'une mesure économique ou de changements institutionnels sur le revenu agricole, et de prévoir les conséquences de ces changements à l'échelle régionale. Nous avons utilisé cette méthode en Tunisie centrale pour estimer la demande en eau d'irrigation en 1999. Nous avons ensuite simulé les changements qui se produiraient si l'irrigation au goutte à goutte a été adoptée. Les résultats de la simulation a montré des économies d'eau et de main-d'½uvre, et une augmentation des rendements, avec une fertigation. Ainsi, l'utilisation de l'irrigation au goutte à goutte peut permettre aux agriculteurs d'étendre leurs superficies irriguées en goutte à goutte. Nous avons ensuite simulé l'adoption généralisée de l'irrigation au goutte à goutte et l'extension des zones irriguées: les résultats n'ont pas montré de baisse de besoins en eau à l'échelle régionale. Ces hypothèses ont été confirmées en 2005 en utilisant de nouvelles typologies pour évaluer la nouvelle demande en eau d'irrigation. Nous avons également simulé les effets de changements économiques sur les revenus agricoles. Une augmentation importante du coût de l'eau a touché une minorité d'exploitations, qui a consommé seulement 17% du total de l'eau d'irrigation, tandis qu'une légère diminution des prix de la pastèque et melon a touché une majorité des exploitations agricoles, qui a consommé 78% du total de l'eau d'irrigation. Les outils de gestion de la demande en eau des doivent donc se concentrer sur les effets d'une technique, des mesures économiques, ou de changements institutionnels et sur les choix des agriculteurs.

Published
2008
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25. Ultrasound Matrix Imaging. I. The focused reflection matrix and the F-factor

Author

Lambert, William, Cobus, Laura, Fink, Mathias, Aubry, Alexandre, Institut Langevin - Ondes et Images (UMR7587) (IL), Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS), PhD thesis of William Lambert funded by the SuperSonic Imagine company, ANR-10-LABX-0024,WIFI,Institut Langevin : Ondes et Images, du Fondamental à l'Innovation(2010), European Project: 819261,REMINISCENCE, European Project: 744840,SMART, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Coherence Factor, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Ultrasound Matrix Imaging, Multiple scattering, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Aberration, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Focusing Factor, [PHYS.PHYS.PHYS-DATA-AN]Physics [physics]/Physics [physics]/Data Analysis, Statistics and Probability [physics.data-an]
Abstract

This is the first article in a series of two dealing with a matrix approach \alex{for} aberration quantification and correction in ultrasound imaging. Advanced synthetic beamforming relies on a double focusing operation at transmission and reception on each point of the medium. Ultrasound matrix imaging (UMI) consists in decoupling the location of these transmitted and received focal spots. The response between those virtual transducers form the so-called focused reflection matrix that actually contains much more information than a raw ultrasound image. In this paper, a time-frequency analysis of this matrix is performed, which highlights the single and multiple scattering contributions as well as the impact of aberrations in the monochromatic and broadband regimes. Interestingly, this analysis enables the measurement of the incoherent input-output point spread function at any pixel of this image. A focusing criterion can then be built, and its evolution used to quantify the amount of aberration throughout the ultrasound image. In contrast to the standard coherence factor used in the literature, this new indicator is robust to multiple scattering and electronic noise, thereby providing a highly contrasted map of the focusing quality. As a proof-of-concept, UMI is applied here to the in-vivo study of a human calf, but it can be extended to any kind of ultrasound diagnosis or non-destructive evaluation.

Published
2021

26. No evidence of hepatitis B virus reactivation among liver transplant recipients treated with interferon- free regimens for hepatitis C virus recurrence (ANRS CO23 CUPILT Cohort)

Author

Mouna, Lina, Rossignol, Emilie, Tateo, Mariagrazia, Duclos-Vallee, Jean-Charles, Duvoux, Christophe, Durand, Francois, Tran, Albert, Radenne, Sylvie, Canva-Delcambre, Valerie, Houssel-Debry, Pauline, Dumortier, Jérôme, Conti, Filomena, De Ledinghen, Victor, Leroy, Vincent, Kamar, Nassim, Di Martino, Vincent, Moreno, Christophe, Fridlund, Danielle M. Botta, D'Alteroche, Louis, Lebray, Pascal, perre, philippe, Besch, Camille, Silvain, Christine, Habersetzer, François, Debette-Gratien, Maryline, Abergel, Armando, Diallo, Alpha, Roque-Afonso, Anne Marie, Pageaux, Georges-Philippe, Jonchère, Laurent, Hôpital Paul Brousse, Université Paris-Sud - Paris 11 (UP11), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie et traitement des maladies du foie, Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), DHU Hepatinov, Service d'Hépatologie, Hôpital Henri Mondor, AP-HP, Créteil, France., Hôpital Henri Mondor, Centre Hospitalier Universitaire de Nice (CHU Nice), Service d'hépatogastroentérologie [Hôpital de la Croix-Rousse, Hospices Civils de Lyon], Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), CHU Pontchaillou [Rennes], Service d'hépatogastroentérologie [Hôpital Edouard Herriot, Hospices Civils de Lyon], Hôpital Edouard Herriot [CHU - HCL], Hôpital St Antoine, Hôpital Haut-Lévêque, Université Sciences et Technologies - Bordeaux 1-CHU Bordeaux [Bordeaux], Hôpital Michallon, CHU Toulouse [Toulouse], Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), CHU Marseille, CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHD Vendee (La Roche Sur Yon), Service d’Hépatogastroentérologie, NHC, CHU de Strasbourg, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, CHU Clermont-Ferrand, ANRS France Recherche Nord & sud Sida-hiv hépatites, Hôpital Lapeyronie [Montpellier] (CHU), Novartis, Astellas, Roche, MSD, GSK, Gilead, Supersonic Imagine, Janssen, Abbvie, Schering-Plough, Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon (CHD Vendée), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Sciences et Technologies - Bordeaux 1 (UB)-CHU Bordeaux [Bordeaux], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Paul Brousse-Université Paris-Sud - Paris 11 (UP11)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

27. Retreatment with sofosbuvir plus grazoprevir plus elbasvir plus ribavirin of patients with Hepatitis C virus Genotype 1 or 4 with RASs at failure of a sofosbuvir plus ledipasvir or plus daclatasvir or plus simeprevir regimen (ANRS HC34 REVENGE study)

Author

Ledinghen, V., Laforest, C., Hezode, C., Pol, S., Renault, A., Alric, L., Larrey, D. G., Metivier, S., Tran, A., Jezequel, C., Didier Samuel, Zoulim, F., Pailhe, A., Gibowski, S., Bourliere, M., Bellissant, E., Pawlotsky, J. M., Jonchère, Laurent, Physiopathologie du cancer du foie, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Pharmacologie [Rennes], CHU Pontchaillou [Rennes], AP HP, Departement Gastroenterologie, Centre Hospitalier Universitaire Henri Mondor, Service d'hépatologie médicale [CHU Cochin], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de Recherche en Santé Digestive (IRSD ), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Cellules souches normales et cancéreuses, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Service de Gastro-entérologie - Hépatologie [Purpan], CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Service des Maladies de l'Appareil Digestif, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Physiopathologie et traitement des maladies du foie, Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hépato-biliaire - CHB [Paul Brousse, Paris], Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'hépato-gastro-entérologie, Assistance Publique - Hôpitaux de Marseille (APHM), Hôpital Saint-Joseph [Marseille], Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, Centre National de Référence Virus des hépatites B, C et Delta, Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Supersonic Imagine, GILEAD, MSD, BMS, ABBVIE, JANSSEN, NOVARTIS, INTERCEPT, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre d'Investigation Clinique [Rennes] ( CIC ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de Pharmacologie, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP], Institut de Recherche en Santé Digestive - IRSD [Purpan, Toulouse], Institut National de la Recherche Agronomique ( INRA ) -Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse ( ENVT ), Institut National Polytechnique de Toulouse ( INPT ) -Institut National Polytechnique de Toulouse ( INPT ) -Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Montpellier 1 ( UM1 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Centre méditérannéen de médecine moléculaire ( C3M ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AP-HP Hôpital Paul Brousse, Université Paris-Sud - Paris 11 ( UP11 ) -AP-HP Hôpital Paul Brousse, Centre de Recherche en Cancérologie de Lyon ( CRCL ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Assistance Publique - Hôpitaux de Marseille ( APHM ), Institut Mondor de Recherche Biomédicale ( IMRB ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Institut National de la Transfusion Sanguine [Paris] ( INTS ) -Assistance publique - Hôpitaux de Paris (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP], Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital Paul Brousse, Université Paris-Sud - Paris 11 (UP11)-AP-HP Hôpital Paul Brousse, Centre de Recherche en Cancérologie de Lyon (CRCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), Service des Maladies de l'Appareil Digestif [CHU Rennes], Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Pôle Maladies de l'appareil digestif [CHU Toulouse], and Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)

Subjects
[SDV] Life Sciences [q-bio], [ SDV ] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], education
Abstract

International audience; 67th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) - Boston, MA - 2016-11-11

Published
2017

28. NON-INVASIVE LIVER FIBROSIS STAGING USING SUPERSONIC SHEAR IMAGING : A CLINICAL STUDY ON 150 PATIENTS

Author

Eric Bavu, jean-luc gennisson, Bruno-Félix Osmanski, Jeremy Bercoff, Mathias Fink, Vincent Mallet, Philippe Sogni, Anaïs Vallet-Pichard, Bertrand Nalpas, Tanter Mickael, Stanislas Pol, Institut Langevin - Ondes et Images (UMR7587) (IL), Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS), Physique des ondes pour la médecine, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), SuperSonic Imagine, Supersonic Imagine, Supersonic Imagine-Supersonic Imagine, Département d'hépatologie [CHU Cochin], Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'hépatologie médicale [CHU Cochin], Hôpital Cochin [AP-HP], Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Langevin - Ondes et Images, Université Paris Diderot - Paris 7 (UPD7)-ESPCI ParisTech-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Cochin [AP-HP]-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Cochin [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Institut Langevin ondes et images, and Centre National de la Recherche Scientifique (CNRS)-ESPCI ParisTech-Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC)

Subjects
[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

29. ClearPEM-Sonic: a multimodal PET-Ultrasound mammography system

Author

Pizzichemi, M, liji, Cao, Di Vara, Nicolas, Felix, Nicolas, A., Grezzi, Juhan, Valérie, Lasaygues, Philippe, Mensah, Serge, Jorge, Neves, Silva, J.C. Rasteiro Da, Tavernier, Stefan, Varela, Joaquim Ignacio, Bugalho, Ricardo, Cucciati, G., Farina, Fabio, Frisch, Benjamin, Auffray, Etiennette, Jun, Dang, Lecoq, Paul, Mudler, Olivier, Paganini, M., Siles, Pascale, Silva-Silva, R., Tessonnier, I., Supersonic Imagine, Ondes et Imagerie (O&I), Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)

Subjects
[PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract

International audience; The ClearPEM-Sonic is a multimodal system dedicated to mammography, capable of providing co-registered metabolic, anatomical and structural information through combination of positron emission tomography with ultrasound elastographic imaging. The project is aimed to improve early stage detection of breast cancer through the high-resolution and high-sensitivity metabolic information provided by PEM, and the high-resolution anatomic information from US. Further improvements in the specificity of the system is provided by the ability to rule out non-cancerous findings from PEM, taking advantage of elastography imaging information. The ClearPEM-Sonic has been developed by the Crystal Clear Collaboration and is currently installed at Hopital Nord, Marseille, in the frame of CERIMED, the European Centre for Research in Medical Imaging. The detector is based on LYSO:Ce crystals, each of 2x2x20 mm3, grouped in 192 matrices of 8x4 crys- tals. BaSO4 is used as coating material and reflector. Read out is performed individually on both 2x2 mm2 faces of each crystal, using avalanche photodiodes (APDs). The detector performance has been thoroughly tested during the commissioning phase, confirming a spatial resolution of 1.5 mm, and a DOI precision of 2 mm. The co-registration software developed has proved to accurately superimpose images coming from the different modalities with a precision better than 2 mm. The clinical trial (phase 1) is being carried out on 20 patients with a known breast lesion who have been injected with FDG for a whole-body PET/CT as part of their diagnostic process. Results are compared to conventional imaging and MRI, with biopsy as a golden standard, to validate the use of ClearPEM-Sonic as a clinical imaging instrument for early detection of breast cancer.

Published
2013
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30. Development of an anthropomorphic breast phantom for combined PET, B-mode ultrasound and elastographic imaging

Author

Serge Mensah, Joao Varela, E. Auffray, P. Lecoq, Dachun Zhang, Mingxi Wan, Philippe Lasaygues, Benjamin Frisch, Jun Dang, S. Tavernier, N. Felix, Université libre de Bruxelles (ULB), European Organization for Nuclear Research (CERN), Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM), Xi'an Jiaotong University (Xjtu), Supersonic Imagine, Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa (INESC-ID), Instituto Superior Técnico, Universidade Técnica de Lisboa (IST)-Instituto de Engenharia de Sistemas e Computadores (INESC), Ondes et Imagerie (O&I), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM), Lasaygues, Philippe, Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), and Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Nuclear and High Energy Physics, medicine.medical_specialty, Nuclear Physics - XX, Breast imaging, Computer science, XX, 01 natural sciences, Imaging phantom, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, 0103 physical sciences, Medical imaging, medicine, Mammography, Medical physics, Electrical and Electronic Engineering, 010301 acoustics, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], medicine.diagnostic_test, business.industry, B mode ultrasound, Ultrasound, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Nuclear Energy and Engineering, Positron emission tomography, Elastography, business, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Biomedical engineering
Abstract

International audience; Combining the advantages of different imaging modalities leads to improved clinical results. For example, ultrasound provides good real-time structural information without any radiation and PET provides sensitive functional information. For the ongoing ClearPEM-Sonic project combining ultrasound and PET for breast imaging, we developed a dual-modality PET/Ultrasound (US) phantom. The phantom reproduces the acoustic and elastic properties of human breast tissue and allows labeling the different tissues in the phantom with different concentrations of FDG. The phantom was imaged with a whole-body PET/CT and with the Supersonic Imagine Aixplorer system. This system allows both B-mode US and shear wave elastographic imaging. US elastography is a new imaging method for displaying the tissue elasticity distribution. It was shown to be useful in breast imaging. We also tested the phantom with static elastography. A 6D magnetic positioning system allows fusing the images obtained with the two modalities. ClearPEM-Sonic is a project of the Crystal Clear Collaboration and the European Centre for Research on Medical Imaging (CERIMED).

Published
2011
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31. Real time quantitative elastography using Supersonic Shear wave Imaging

Author

Mathieu Couade, Emilie Mace, Gabriel Montaldo, Mathias Fink, Mathieu Pernot, Eric Bavu, Jean-Luc Gennisson, Thu-Mai Nguyen, Mickael Tanter, Physique des ondes pour la médecine, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Langevin - Ondes et Images (UMR7587) (IL), Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS), Supersonic Imagine, Institut Langevin - Ondes et Images, Université Paris Diderot - Paris 7 (UPD7)-ESPCI ParisTech-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-ESPCI ParisTech-Université Paris Diderot - Paris 7 (UPD7), Laboratoire ondes et acoustique (LOA), Université Paris Diderot - Paris 7 (UPD7)-ESPCI ParisTech-Centre National de la Recherche Scientifique (CNRS), Institut Langevin ondes et images, and Centre National de la Recherche Scientifique (CNRS)-ESPCI ParisTech-Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC)

Subjects
medicine.medical_specialty, Shear waves, Materials science, diagnosis, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Acoustics, 01 natural sciences, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, 0103 physical sciences, medicine, Medical imaging, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, cancer, Supersonic speed, 010301 acoustics, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], medicine.diagnostic_test, business.industry, ultrasound, Ultrasound, Stiffness, Frame rate, ultrafast imaging, 3. Good health, Shear (geology), Radiology, Elastography, medicine.symptom, business
Abstract

International audience; Supersonic Shear Imaging (SSI) is a quantitative stiffness imaging technique based on the combination of a radiation force induced in tissue by an ultrasonic beam and ultrafast ultrasound imaging sequence (up to more than 10000 frames per second) catching in real time the propagation of the resulting shear waves. Local shear wave speed is estimated and enables the two dimensional mapping of shear elasticity. This imaging modality is implemented on conventional probes driven by dedicated ultrafast echographic devices and can be performed during a standard ultrasound exam. The clinical potential of SSI is today extensively investigated for many potential applications such as breast cancer diagnosis, liver fibrosis staging, cardiovascular applications, ophthalmology. This invited lecture presents a short overview of the current investigated applications of SSI.

Published
2010
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32. Development of anthropomorphic phantoms for combined PET-ultrasound breast imaging

Author

Dang, Jun, Lasaygues, Philippe, Zhang, Dachun, Tavernier, Stephan, Felix, Nicolas, Frish, Benjamin, Mensah, Serge, Wan, Mingxi, Lasaygues, Philippe, Université libre de Bruxelles (ULB), Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM), Xi'an Jiaotong University (Xjtu), Supersonic Imagine, European Organization for Nuclear Research (CERN), and Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], equipment and supplies, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract

International audience; As part of the development a combined PET-Ultrasound multimodal scanner for breast imaging by the Crystal Clear collaboration (The ClearPEM-Sonic project) we have developed and tested a phantom that can be used for making realistic images with both modalities. In a first step we measured the propagation velocities of the acoustic waves, the attenuation coefficient and the elasticity (Young's modulus) for several series of different samples based on gelatine and agar mixtures. We determined which preparations reproduce the acoustical and elastic properties of different body tissues of interest in breast imaging such as fat tissue, glandular tissue, fibrous tissue and carcinomat tissue. In a second step we have built phantoms where we added a small amount of FDG (WHAT IS FDG?) during the preparation of the phantom such as to give the different parts in the phantom activities similar to what is usually present in the breast during PET imaging. The phantom was than imaged on a Philips Gemini TF PET/CT and on a US scanner from ATL, HDI 5000. The images were superposed using rigid transformations to produce combined PET/US images. We also evaluated the performance of our phantoms for US elastographic imaging. Details on the procedure for producing the phantoms will be given.

Published
2009

33. In vivo assessment of shear modulus along the fibers of pennate muscle during passive lengthening and contraction using steered ultrasound push beams.

Author

Andrade RJ, Ngo HH, Lemoine A, Racapé A, Etaix N, Frappart T, Fraschini C, Gennisson JL, and Nordez A

Abstract

Ultrasound shear wave elastography (SWE) has emerged as a promising non-invasive method for muscle evaluation by assessing the propagation velocity of an induced shear wavefront. In skeletal muscles, the propagation of shear waves is complex, depending not only on the mechanical and acoustic properties of the tissue but also upon its geometry. This study aimed to comprehensively investigate the influence of muscle pennation angle on the shear wave propagation, which is directly related to the shear modulus. A novel elastography method based on steered pushing beams (SPB) was used to assess the shear modulus along the fibers of the gastrocnemius medialis (pennate) muscle in twenty healthy volunteers. Ultrasound scans were performed during passive muscle lengthening (n = 10) and submaximal isometric contractions (n = 10). The shear modulus along the fibers was compared to the apparent shear modulus, as commonly assessed along the muscle shortening direction using conventional SWE sequences. The shear modulus along the muscle fibers was significantly greater than the apparent shear modulus for passive dorsiflexion angles, while not significantly different throughout the range of plantar flexion angles (i.e., under any or very low tensile loads). The concomitant decrease in pennation angle along with the gradual increase in the shear modulus difference between the two methods as the muscle lengthens, strongly indicates that non-linear elasticity exerts a greater influence on wave propagation than muscle geometry. In addition, significant differences between methods were found across all submaximal contractions, with both shear modulus along the fibers and the pennation angle increasing with the contraction intensity. Specifically, incremental contraction intensity led to a greater bias than passive lengthening, which could be partly explained by distinct changes in pennation angle. Overall, the new SPB sequence provides a rapid and integrated geometrical correction of shear modulus quantification in pennate muscles, thereby eliminating the necessity for specialized systems to align the ultrasound transducer array with the fiber's orientation. We believe that this will contribute for improving the accuracy of SWE in biomechanical and clinical settings., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Published
2024
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34. Reflection Measurement of the Scattering Mean Free Path at the Onset of Multiple Scattering.

Author

Goïcoechea A, Brütt C, Le Ber A, Bureau F, Lambert W, Prada C, Derode A, and Aubry A

Abstract

Multiple scattering of waves presents challenges for imaging complex media but offers potential for their characterization. Its onset is actually governed by the scattering mean free path ℓ&#95;{s} that provides crucial information on the medium microarchitecture. Here, we introduce a reflection matrix method designed to estimate this parameter from the time decay of the single scattering rate. Our method is first validated by an ultrasound experiment on a tissue-mimicking phantom before being applied in vivo to a human liver. This Letter opens important perspectives for quantitative imaging of heterogeneous media with waves, whether it be for nondestructive testing, biomedical, or geophysical applications.

Published
2024
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35. In plane quantification of in vivo muscle elastic anisotropy factor by steered ultrasound pushing beams.

Author

Ngo HH, Andrade R, Brum J, Benech N, Chatelin S, Loumeaud A, Frappart T, Fraschini C, Nordez A, and Gennisson JL

Subjects
Animals, Cattle, Anisotropy, Ultrasonography, Elastic Modulus physiology, Biomarkers, Muscle, Skeletal diagnostic imaging, Muscle, Skeletal physiology, Elasticity Imaging Techniques methods
Abstract

Objective. Skeletal muscles are organized into distinct layers and exhibit anisotropic characteristics across various scales. Assessing the arrangement of skeletal muscles may provide valuable biomarkers for diagnosing muscle-related pathologies and evaluating the efficacy of clinical interventions. Approach . In this study, we propose a novel ultrafast ultrasound sequence constituted of steered pushing beams was proposed for ultrasound elastography applications in transverse isotropic muscle. Based on the propagation of the shear wave vertical mode, it is possible to fit the experimental results to retrieve in the same imaging plane, the shear modulus parallel to fibers as well as the elastic anisotropy factor (ratio of Young's moduli times the shear modulus perpendicular to fibers). Main results . The technique was demonstrated in vitro in phantoms and ex vivo in fusiform beef muscles. At last, the technique was applied in vivo on fusiform muscles ( biceps brachii ) and mono-pennate muscles ( gastrocnemius medialis ) during stretching and contraction. Significance . This novel sequence provides access to new structural and mechanical biomarkers of muscle tissue, including the elastic anisotropy factor, within the same imaging plane. Additionally, it enables the investigation of multiples parameters during muscle active and passive length changes., (© 2024 Institute of Physics and Engineering in Medicine.)

Published
2024
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36. Three-dimensional ultrasound matrix imaging.

Author

Bureau F, Robin J, Le Ber A, Lambert W, Fink M, and Aubry A

Abstract

Matrix imaging paves the way towards a next revolution in wave physics. Based on the response matrix recorded between a set of sensors, it enables an optimized compensation of aberration phenomena and multiple scattering events that usually drastically hinder the focusing process in heterogeneous media. Although it gave rise to spectacular results in optical microscopy or seismic imaging, the success of matrix imaging has been so far relatively limited with ultrasonic waves because wave control is generally only performed with a linear array of transducers. In this paper, we extend ultrasound matrix imaging to a 3D geometry. Switching from a 1D to a 2D probe enables a much sharper estimation of the transmission matrix that links each transducer and each medium voxel. Here, we first present an experimental proof of concept on a tissue-mimicking phantom through ex-vivo tissues and then, show the potential of 3D matrix imaging for transcranial applications., (© 2023. Springer Nature Limited.)

Published
2023
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37. Comparison of ultrasound elastography, magnetic resonance elastography and finite element model to quantify nonlinear shear modulus.

Author

Pagé G, Bied M, Garteiser P, Van Beers B, Etaix N, Fraschini C, Bel-Brunon A, and Gennisson JL

Subjects
Finite Element Analysis, Ultrasonography, Ultrasonics, Models, Theoretical, Phantoms, Imaging, Elastic Modulus, Elasticity Imaging Techniques methods
Abstract

Objective . The aim of this study is to validate the estimation of the nonlinear shear modulus (A) from the acoustoelasticity theory with two experimental methods, ultrasound (US) elastography and magnetic resonance elastography (MRE), and a finite element method. Approach . Experiments were performed on agar (2%)-gelatin (8%) phantom considered as homogeneous, elastic and isotropic. Two specific setups were built to ensure a uniaxial stress step by step on the phantom, one for US and a nonmagnetic version for MRE. The stress was controlled identically in both imaging techniques, with a water tank placed on the top of the phantom and filled with increasing masses of water during the experiment. In US, the supersonic shear wave elastography was implemented on an ultrafast US device, driving a 6 MHz linear array to measure shear wave speed. In MRE, a gradient-echo sequence was used in which the three spatial directions of a 40 Hz continuous wave displacement generated with an external driver were encoded successively. Numerically, a finite element method was developed to simulate the propagation of the shear wave in a uniaxially stressed soft medium. Main results . Similar shear moduli were estimated at zero stress using experimental methods,μ0US= 12.3 ± 0.3 kPa andμ0MRE= 11.5 ± 0.7 kPa. Numerical simulations were set with a shear modulus of 12 kPa and the resulting nonlinear shear modulus was found to be -58.1 ± 0.7 kPa. A very good agreement between the finite element model and the experimental models (AUS= -58.9 ± 9.9 kPa andAMRE= -52.8 ± 6.5 kPa) was obtained. Significance . These results show the validity of such nonlinear shear modulus measurement quantification in shear wave elastography. This work paves the way to develop nonlinear elastography technique to get a new biomarker for medical diagnosis., (© 2023 Institute of Physics and Engineering in Medicine.)

Published
2023
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38. Pulse-echo speed-of-sound imaging using convex probes.

Author

Jaeger M, Stähli P, Martiartu NK, Yolgunlu PS, Frappart T, Fraschini C, and Frenz M

Subjects
Phantoms, Imaging, Ultrasonography methods, Sound, Tomography methods, Tomography, X-Ray Computed
Abstract

Computed ultrasound tomography in echo mode (CUTE) is a new ultrasound (US)-based medical imaging modality with promise for diagnosing various types of disease based on the tissue's speed of sound (SoS). It is developed for conventional pulse-echo US using handheld probes and can thus be implemented in state-of-the-art medical US systems. One promising application is the quantification of the liver fat fraction in fatty liver disease. So far, CUTE was using linear array probes where the imaging depth is comparable to the aperture size. For liver imaging, however, convex probes are preferred since they provide a larger penetration depth and a wider view angle allowing to capture a large area of the liver. With the goal of liver imaging in mind, we adapt CUTE to convex probes, with a special focus on discussing strategies that make use of the convex geometry in order to make our implementation computationally efficient. We then demonstrate in an abdominal imaging phantom that accurate quantitative SoS using convex probes is feasible, in spite of the smaller aperture size in relation to the image area compared to linear arrays. A preliminary in vivo result of liver imaging confirms this outcome, but also indicates that deep quantitative imaging in the real liver can be more challenging, probably due to the increased complexity of the tissue compared to phantoms., (Creative Commons Attribution license.)

Published
2022
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39. Radiological Society of North America/Quantitative Imaging Biomarker Alliance Shear Wave Speed Bias Quantification in Elastic and Viscoelastic Phantoms.

Author

Palmeri ML, Milkowski A, Barr R, Carson P, Couade M, Chen J, Chen S, Dhyani M, Ehman R, Garra B, Gee A, Guenette G, Hah Z, Lynch T, Macdonald M, Managuli R, Miette V, Nightingale KR, Obuchowski N, Rouze NC, Morris DC, Fielding S, Deng Y, Chan D, Choudhury K, Yang S, Samir AE, Shamdasani V, Urban M, Wear K, Xie H, Ozturk A, Qiang B, Song P, McAleavey S, Rosenzweig S, Wang M, Okamura Y, McLaughlin G, Chen Y, Napolitano D, Carlson L, Erpelding T, and Hall TJ

Subjects
Biomarkers, Elasticity, Humans, North America, Phantoms, Imaging, Elasticity Imaging Techniques
Abstract

Objectives: To quantify the bias of shear wave speed (SWS) measurements between different commercial ultrasonic shear elasticity systems and a magnetic resonance elastography (MRE) system in elastic and viscoelastic phantoms., Methods: Two elastic phantoms, representing healthy through fibrotic liver, were measured with 5 different ultrasound platforms, and 3 viscoelastic phantoms, representing healthy through fibrotic liver tissue, were measured with 12 different ultrasound platforms. Measurements were performed with different systems at different sites, at 3 focal depths, and with different appraisers. The SWS bias across the systems was quantified as a function of the system, site, focal depth, and appraiser. A single MRE research system was also used to characterize these phantoms using discrete frequencies from 60 to 500 Hz., Results: The SWS from different systems had mean difference 95% confidence intervals of ±0.145 m/s (±9.6%) across both elastic phantoms and ± 0.340 m/s (±15.3%) across the viscoelastic phantoms. The focal depth and appraiser were less significant sources of SWS variability than the system and site. Magnetic resonance elastography best matched the ultrasonic SWS in the viscoelastic phantoms using a 140 Hz source but had a - 0.27 ± 0.027-m/s (-12.2% ± 1.2%) bias when using the clinically implemented 60-Hz vibration source., Conclusions: Shear wave speed reconstruction across different manufacturer systems is more consistent in elastic than viscoelastic phantoms, with a mean difference bias of < ±10% in all cases. Magnetic resonance elastographic measurements in the elastic and viscoelastic phantoms best match the ultrasound systems with a 140-Hz excitation but have a significant negative bias operating at 60 Hz. This study establishes a foundation for meaningful comparison of SWS measurements made with different platforms., (© 2021 American Institute of Ultrasound in Medicine.)

Published
2021
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40. Distortion matrix approach for ultrasound imaging of random scattering media.

Author

Lambert W, Cobus LA, Frappart T, Fink M, and Aubry A

Subjects
Acoustics, Fourier Analysis, Humans, Leg diagnostic imaging, Phantoms, Imaging, Scattering, Radiation, Image Processing, Computer-Assisted methods, Ultrasonography methods
Abstract

Focusing waves inside inhomogeneous media is a fundamental problem for imaging. Spatial variations of wave velocity can strongly distort propagating wave fronts and degrade image quality. Adaptive focusing can compensate for such aberration but is only effective over a restricted field of view. Here, we introduce a full-field approach to wave imaging based on the concept of the distortion matrix. This operator essentially connects any focal point inside the medium with the distortion that a wave front, emitted from that point, experiences due to heterogeneities. A time-reversal analysis of the distortion matrix enables the estimation of the transmission matrix that links each sensor and image voxel. Phase aberrations can then be unscrambled for any point, providing a full-field image of the medium with diffraction-limited resolution. Importantly, this process is particularly efficient in random scattering media, where traditional approaches such as adaptive focusing fail. Here, we first present an experimental proof of concept on a tissue-mimicking phantom and then, apply the method to in vivo imaging of human soft tissues. While introduced here in the context of acoustics, this approach can also be extended to optical microscopy, radar, or seismic imaging., Competing Interests: Competing interest statement: W.L., L.A.C, M.F., and A.A. are named inventors on patents filed by the CNRS related to the distortion matrix approach. M.F. is cofounder of the SuperSonic Imagine company, which is commercializing the ultrasound platform used in this study. W.L. has his PhD funded by the SuperSonic Imagine company, and T.F. is an employee of this company.

Published
2020
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41. Ultrasensitive Doppler as a tool for the diagnosis of testicular ischemia during the Valsalva maneuver: a new way to explore varicoceles?

Author

Rocher L, Gennisson JL, Baranger J, Rachas A, Criton A, Izard V, Bertolloto M, Bellin MF, and Correas JM

Subjects
Adult, Humans, Male, Prospective Studies, Reproducibility of Results, Varicocele pathology, Testis diagnostic imaging, Testis pathology, Ultrasonography, Doppler methods, Valsalva Maneuver, Varicocele diagnostic imaging
Published
2019
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42. Characterization of Testicular Masses in Adults: Performance of Combined Quantitative Shear Wave Elastography and Conventional Ultrasound.

Author

Rocher L, Criton A, Gennisson JL, Creze M, Albiges L, Ferlicot S, Bellin MF, Izard V, and Correas JM

Subjects
Adult, Aged, Aged, 80 and over, Diagnosis, Differential, Elasticity Imaging Techniques, Humans, Male, Middle Aged, Prospective Studies, Reproducibility of Results, Sensitivity and Specificity, Testis diagnostic imaging, Young Adult, Testicular Neoplasms diagnostic imaging, Ultrasonography methods
Abstract

We prospectively evaluated the performance of combined shear wave elastography (SWE) and conventional ultrasound (US) for the characterization of 89 testicular focal masses. Testes were evaluated with B-mode, color Doppler and SWE measurements, locating a region of interest on the normal and pathologic parenchyma. Thirty-seven malignant tumors (MTs), 12 burned out tumors (BOTs), 28 Leydig cell tumors (LCTs), 2 dermoid cysts and other benign lesions were included. MTs + BOTs exhibited more microliths and macrocalcifications compared with benign lesions (p < 10 -4 ). LCTs manifested mostly a dominant peripheral vascularization pattern compared with other lesions. MTs + BOTs were stiffer compared with benign lesions (p < 2 × 10 -4 ) but with a moderate area under the receiver operating characteristic curve (AUROC) of 80%. By focusing on LCTs versus MTs + BOTs, diagnostic performance led to an AUROC of 89% for the best stiffness parameter. For combined conventional US and SWE, the diagnostic performance to differentiate all benign lesions versus MTs + BOTs and LCTs versus MTs + BOTs increased to AUROCs of 93% and 98%, respectively., (Copyright © 2018 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.)

Published
2019
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43. Confirmed value of shear wave elastography for ultrasound characterization of breast masses using a conservative approach in Chinese women: a large-size prospective multicenter trial.

Author

Lin X, Chang C, Wu C, Chen Q, Peng Y, Luo B, Tang L, Li J, Zheng J, Zhou R, Cui G, Li A, Wang X, Qian L, Zhang J, Wen C, Gay J, Zhang H, Li A, and Chen Y

Abstract

Purpose: This study aimed to investigate the value of shear wave elastography (SWE) for characterization of breast masses in a Chinese population., Patients and Methods: Two thousand two hundred seventy-three women consented to be prospectively enrolled for the characterization of breast masses with ultrasound and SWE. Breast masses were known from symptoms, palpability, and/or previous imaging screening with mammography and/or ultrasound. Correlation of SWE qualitative and quantitative features with malignancy risk and impact on diagnostic performance of combining SWE features were assessed, and the Breast Imaging Reporting and Data System (BI-RADS) scoring was calculated using histopathology as reference., Results: Data of 2,262 masses (median size: 13 mm; range: 1.3-50) from 2,262 patients (median age: 43 years; range: 18-91) were investigated, of which 752 (33.3%) were malignant. Sensitivity and specificity of BI-RADS diagnosis were 97.5% (733/752) and 54.8% (827/1,510), respectively. By logistic regression, the combination of maximum elasticity ( E max ) measurements with BI-RADS assessments increased the area under the receiver operating characteristic curve from 0.908 (95% CI: 0.896-0.920) to 0.954 (95% CI: 0.944-0.962). Using E max of 30 kPa or lower to selectively downgrade BI-RADS 4a masses to follow-up, and E max of 160 kPa or higher to selectively upgrade BI-RADS 3 lesions to biopsy, specificity significantly increased from 54.8% (827/1,510) to 66.1% (998/1,510) ( P <0.001) while sensitivity decreased nonsignificantly from 97.5% (733/752) to 96.9% (729/752) ( P =0.2891). Positive predictive value for biopsy recommendation increased from 51.7% (733/1,417) to 58.7% (729/1,241) ( P <0.001)., Conclusion: Adding SWE maximum stiffness to BI-RADS 3 and BI-RADS 4a breast masses in a Chinese population increased significantly the specificity of breast ultrasonography, without significant change in sensitivity., Competing Interests: Disclosure The authors report no conflicts of interest in this work.

Published
2018
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44. Testicular ultrasensitive Doppler preliminary experience: a feasibility study.

Author

Rocher L, Gennisson JL, Ferlicot S, Criton A, Albiges L, Izard V, Bellin MF, and Correas JM

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Feasibility Studies, Humans, Male, Middle Aged, Prospective Studies, Reproducibility of Results, Sensitivity and Specificity, Young Adult, Scrotum diagnostic imaging, Testicular Diseases diagnostic imaging, Ultrasonography, Doppler methods
Abstract

Background Ultrasensitive Doppler is a novel non-invasive ultrasound (US) Doppler technique that improves sensitivity and resolution for the detection of slow flow. Purpose To investigate the feasibility of ultrasensitive Doppler (USD) for testicular disease diagnosis, using both qualitative and quantitative results. Material and Methods This prospective study was conducted in 160 successive men referred for scrotal US including B-mode and conventional Color-Doppler. A new USD sequence and algorithm dedicated to academic research were implemented into the US system. The quality criterion for a successful examination was the detection of well delineated intratesticular vessels. Qualitative USD results were described in terms of tumor vascular architecture and flow intensity for different pathologies for 41 patients. The testicular vascularization (TV), defined as a vessel's surface ratio, was quantified using customized MATLAB® software and compared in azoospermic and normal patients. Results USD was acquired successfully in 153/160 patients (95.6%). The tumor vascular architecture differed depending on the nature of the tumors. Leydig cell tumors exhibited mostly circumferential vascularization, while germ cell tumors exhibited straight vessels through the tumors, or anarchic vascular maps. USD improved the diagnostic performance of testicular Doppler US in a case of incomplete spermatic cord torsion and acute epididymitis. The reproducibility of TV measurements established an interclass correlation of 0.801. Non-Klinefelter syndrome non-obstructive azoospermia patients exhibited a lower TV compared to normal patients, to Klinefelter syndrome, and to obstructive azoospermia patients ( P < 0.002, P < 0.005, and P < 0.05, respectively). Conclusion Testicular USD can become a promising technique for improving US diagnosis of tumors, acute scrotum, and for determining infertility status.

Published
2018
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45. Assessment of biopsy-proven liver fibrosis by two-dimensional shear wave elastography: An individual patient data-based meta-analysis.

Author

Herrmann E, de Lédinghen V, Cassinotto C, Chu WC, Leung VY, Ferraioli G, Filice C, Castera L, Vilgrain V, Ronot M, Dumortier J, Guibal A, Pol S, Trebicka J, Jansen C, Strassburg C, Zheng R, Zheng J, Francque S, Vanwolleghem T, Vonghia L, Manesis EK, Zoumpoulis P, Sporea I, Thiele M, Krag A, Cohen-Bacrie C, Criton A, Gay J, Deffieux T, and Friedrich-Rust M

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Biopsy, Needle, Databases, Factual, Disease Progression, Female, Follow-Up Studies, Hepatitis B, Chronic diagnostic imaging, Hepatitis B, Chronic pathology, Hepatitis C, Chronic diagnostic imaging, Hepatitis C, Chronic pathology, Humans, Immunohistochemistry, Liver Cirrhosis etiology, Liver Cirrhosis virology, Male, Middle Aged, Odds Ratio, ROC Curve, Severity of Illness Index, Young Adult, Elasticity Imaging Techniques methods, Hepatitis B, Chronic complications, Hepatitis C, Chronic complications, Liver Cirrhosis diagnostic imaging, Liver Cirrhosis pathology
Abstract

Two-dimensional shear wave elastography (2D-SWE) has proven to be efficient for the evaluation of liver fibrosis in small to moderate-sized clinical trials. We aimed at running a larger-scale meta-analysis of individual data. Centers which have worked with Aixplorer ultrasound equipment were contacted to share their data. Retrospective statistical analysis used direct and paired receiver operating characteristic and area under the receiver operating characteristic curve (AUROC) analyses, accounting for random effects. Data on both 2D-SWE and liver biopsy were available for 1,134 patients from 13 sites, as well as on successful transient elastography in 665 patients. Most patients had chronic hepatitis C (n = 379), hepatitis B (n = 400), or nonalcoholic fatty liver disease (n = 156). AUROCs of 2D-SWE in patients with hepatitis C, hepatitis B, and nonalcoholic fatty liver disease were 86.3%, 90.6%, and 85.5% for diagnosing significant fibrosis and 92.9%, 95.5%, and 91.7% for diagnosing cirrhosis, respectively. The AUROC of 2D-SWE was 0.022-0.084 (95% confidence interval) larger than the AUROC of transient elastography for diagnosing significant fibrosis (P = 0.001) and 0.003-0.034 for diagnosing cirrhosis (P = 0.022) in all patients. This difference was strongest in hepatitis B patients., Conclusion: 2D-SWE has good to excellent performance for the noninvasive staging of liver fibrosis in patients with hepatitis B; further prospective studies are needed for head-to-head comparison between 2D-SWE and other imaging modalities to establish disease-specific appropriate cutoff points for assessment of fibrosis stage. (Hepatology 2018;67:260-272)., (© 2017 The Authors. Hepatology published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.)

Published
2018
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46. A Machine-Learning Algorithm Toward Color Analysis for Chronic Liver Disease Classification, Employing Ultrasound Shear Wave Elastography.

Author

Gatos I, Tsantis S, Spiliopoulos S, Karnabatidis D, Theotokas I, Zoumpoulis P, Loupas T, Hazle JD, and Kagadis GC

Subjects
Adolescent, Aged, Algorithms, Chronic Disease, Color, Female, Humans, Liver diagnostic imaging, Male, Middle Aged, Sensitivity and Specificity, Young Adult, Diagnosis, Computer-Assisted methods, Elasticity Imaging Techniques methods, Liver Diseases diagnostic imaging, Machine Learning
Abstract

The purpose of the present study was to employ a computer-aided diagnosis system that classifies chronic liver disease (CLD) using ultrasound shear wave elastography (SWE) imaging, with a stiffness value-clustering and machine-learning algorithm. A clinical data set of 126 patients (56 healthy controls, 70 with CLD) was analyzed. First, an RGB-to-stiffness inverse mapping technique was employed. A five-cluster segmentation was then performed associating corresponding different-color regions with certain stiffness value ranges acquired from the SWE manufacturer-provided color bar. Subsequently, 35 features (7 for each cluster), indicative of physical characteristics existing within the SWE image, were extracted. A stepwise regression analysis toward feature reduction was used to derive a reduced feature subset that was fed into the support vector machine classification algorithm to classify CLD from healthy cases. The highest accuracy in classification of healthy to CLD subject discrimination from the support vector machine model was 87.3% with sensitivity and specificity values of 93.5% and 81.2%, respectively. Receiver operating characteristic curve analysis gave an area under the curve value of 0.87 (confidence interval: 0.77-0.92). A machine-learning algorithm that quantifies color information in terms of stiffness values from SWE images and discriminates CLD from healthy cases is introduced. New objective parameters and criteria for CLD diagnosis employing SWE images provided by the present study can be considered an important step toward color-based interpretation, and could assist radiologists' diagnostic performance on a daily basis after being installed in a PC and employed retrospectively, immediately after the examination., (Copyright © 2017 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.)

Published
2017
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47. Ex vivo optimisation of a heterogeneous speed of sound model of the human skull for non-invasive transcranial focused ultrasound at 1 MHz.

Author

Marsac L, Chauvet D, La Greca R, Boch AL, Chaumoitre K, Tanter M, and Aubry JF

Subjects
Aged, 80 and over, Humans, Tomography, X-Ray Computed, High-Intensity Focused Ultrasound Ablation, Models, Biological, Skull diagnostic imaging, Sound
Abstract

Transcranial brain therapy has recently emerged as a non-invasive strategy for the treatment of various neurological diseases, such as essential tremor or neurogenic pain. However, treatments require millimetre-scale accuracy. The use of high frequencies (typically ≥1 MHz) decreases the ultrasonic wavelength to the millimetre scale, thereby increasing the clinical accuracy and lowering the probability of cavitation, which improves the safety of the technique compared with the use of low-frequency devices that operate at 220 kHz. Nevertheless, the skull produces greater distortions of high-frequency waves relative to low-frequency waves. High-frequency waves require high-performance adaptive focusing techniques, based on modelling the wave propagation through the skull. This study sought to optimise the acoustical modelling of the skull based on computed tomography (CT) for a 1 MHz clinical brain therapy system. The best model tested in this article corresponded to a maximum speed of sound of 4000 m.s -1 in the skull bone, and it restored 86% of the optimal pressure amplitude on average in a collection of six human skulls. Compared with uncorrected focusing, the optimised non-invasive correction led to an average increase of 99% in the maximum pressure amplitude around the target and an average decrease of 48% in the distance between the peak pressure and the selected target. The attenuation through the skulls was also assessed within the bandwidth of the transducers, and it was found to vary in the range of 10 ± 3 dB at 800 kHz and 16 ± 3 dB at 1.3 MHz.

Published
2017
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48. Testicular Shear Wave Elastography in Normal and Infertile Men: A Prospective Study on 601 Patients.

Author

Rocher L, Criton A, Gennisson JL, Izard V, Ferlicot S, Tanter M, Benoit G, Bellin MF, and Correas JM

Subjects
Humans, Male, Prospective Studies, Reproducibility of Results, Elasticity Imaging Techniques methods, Infertility diagnostic imaging, Testis diagnostic imaging
Abstract

Our aim in the study described here was to prospectively establish the feasibility of using and reproducibility of testicular shear-wave elastography in the assessment of testicular stiffness in 62 normal patients and 539 infertile men with obstructive azoospermia (OA), non-Klinefelter syndrome non-obstructive azoospermia (non-KS NOA), Klinefelter syndrome NOA (KS NOA), oligoasthenoteratozoospermia (OAT) or a left varicocele. The feasibility rate was 96.9%, with an intra-class correlation coefficient of 0.85 (95% confidence interval: 0.83-0.88). Median stiffness (interquartile range) values were 2.4 kPa (2.0, 2.9), 2.1 kPa (1.8, 2.5), 2.4 kPa (2.0, 2.7), 2.0 kPa (1.7, 2.4), 2.6 kPa (2, 3.2) and 2.2 kPa (1.8, 2.6) for men with a normal testis (n = 108), OAT (n = 689), OA (n = 119), non-KS NOA (n = 183), KS NOA (n = 70) and varicocele (n = 132), respectively. Testicular shear wave elastography is a feasible and reproducible technique. A significant positive association was found between stiffness and testis volume (p = 0.001). Testicular stiffness was higher in OA than in non-KS NOA populations (p = 1.e-10) and in KS NOA than in NOA populations (p = 2.0e-8), but the substantial number of overlapping values limited the clinical impact., (Copyright © 2016 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.)

Published
2017
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49. Feasibility of Imaging and Treatment Monitoring of Breast Lesions with Three-Dimensional Shear Wave Elastography.

Author

Athanasiou A, Latorre-Ossa H, Criton A, Tardivon A, Gennisson JL, and Tanter M

Subjects
Adult, Aged, Breast Neoplasms drug therapy, Chemotherapy, Adjuvant, Feasibility Studies, Humans, Magnetic Resonance Imaging methods, Mammography methods, Middle Aged, Neoadjuvant Therapy, Prospective Studies, Treatment Outcome, Tumor Burden physiology, Breast Neoplasms diagnostic imaging, Elasticity Imaging Techniques methods, Imaging, Three-Dimensional methods, Ultrasonography, Mammary methods
Abstract

Purpose  Firstly to evaluate the feasibility and diagnostic performance of three-dimensional (3 D) shear wave elastography (SWE) volume measurements in patients with breast lesions compared to breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) lesion volumes and 3D-US B-mode volumes. Secondly to assess the treatment monitoring performance of 3D-SWE in patients under neoadjuvant chemotherapy for breast cancer by comparing it to 3D-US lesion volume. Materials and Methods  This prospective study was approved by the institutional review board. Informed consent was provided. 33 patients with 33 lesions were included. The feasibility of 3D-SWE was evaluated in 23 patients. In the 10 remaining patients receiving neoadjuvant chemotherapy, 3D-SWE was evaluated before and during treatment. Tumor volume and qualitative and quantitative elasticity analysis measurements were performed and compared to the tumor volume as estimated by 3D-US and DCE-MRI. Statistical analysis was performed using the Pearson correlation coefficient. Results  3D-SWE was feasible in patients with breast lesions. Tumor volume calculated with 3D-US and 3D-SWE showed very good and moderate concordances with DCE-MRI volume, respectively (Pearson correlation coefficients equal to ρ = r = 0.88, p < 0.00 002 and ρ = r = 0.5, p = 0.32, respectively). Modification of tumor elasticity and heterogeneity was correlated with response to treatment. In good responders, elasticity and elasticity heterogeneity diminished. Conclusion  Tumor 3D-US volume measurements showed very good concordance with DCE-MRI volume. 3D-SWE can provide valuable information: reduction of tissue stiffness during treatment could be a potential indicator of response. These preliminary results should be confirmed on a larger number of patients., (© Georg Thieme Verlag KG Stuttgart · New York.)

Published
2017
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50. Shear Wave Imaging of Passive Diastolic Myocardial Stiffness: Stunned Versus Infarcted Myocardium.

Author

Pernot M, Lee WN, Bel A, Mateo P, Couade M, Tanter M, Crozatier B, and Messas E

Subjects
Animals, Biomechanical Phenomena, Cardiomyopathies physiopathology, Diastole, Disease Models, Animal, Elastic Modulus, Myocardial Infarction physiopathology, Myocardial Stunning physiopathology, Predictive Value of Tests, Sheep, Domestic, Time Factors, Ventricular Pressure, Cardiomyopathies diagnostic imaging, Myocardial Infarction diagnostic imaging, Myocardial Stunning diagnostic imaging, Ultrasonography methods, Ventricular Function, Left
Abstract

Objectives: The aim of this study was to investigate the potential of shear wave imaging (SWI), a novel ultrasound-based technique, to noninvasively quantify passive diastolic myocardial stiffness in an ovine model of ischemic cardiomyopathy., Background: Evaluation of diastolic left ventricular function is critical for evaluation of heart failure and ischemic cardiomyopathy. Myocardial stiffness is known to be an important property for the evaluation of the diastolic myocardial function, but this parameter cannot be measured noninvasively by existing techniques., Methods: SWI was performed in vivo in open-chest procedures in 10 sheep. Ligation of a diagonal of the left anterior descending coronary artery was performed for 15 min (stunned group, n = 5) and 2 h (infarcted group, n = 5). Each procedure was followed by a 40-min reperfusion period. Diastolic myocardial stiffness was measured at rest, during ischemia, and after reperfusion by using noninvasive shear wave imaging. Simultaneously, end-diastolic left ventricular pressure and segmental strain were measured with a pressure catheter and sonomicrometers during transient vena caval occlusions to obtain gold standard evaluation of myocardial stiffness using end-diastolic strain-stress relationship (EDSSR)., Results: In both groups, the end-systolic circumferential strain was drastically reduced during ischemia (from 14.2 ± 1.2% to 1.3 ± 1.6% in the infarcted group and from 13.5 ± 3.0% to 1.9 ± 1.8% in the stunned group; p <0.01). SWI diastolic stiffness increased after 2 h of ischemia from 1.7 ± 0.4 to 6.2 ± 2.2 kPa (p < 0.05) and even more after reperfusion (12.1 ± 4.2 kPa; p < 0.01). Diastolic myocardial stiffening was confirmed by the exponential constant coefficient of the EDSSR, which increased from 8.8 ± 2.3 to 25.7 ± 9.5 (p < 0.01). In contrast, SWI diastolic stiffness was unchanged in the stunned group (2.3 ± 0.4 kPa vs 1.8 ± 0.3 kPa, p = NS) which was confirmed also by the exponential constant of EDSSR (9.7 ± 3.1 vs 10.2 ± 2.3, p = NS)., Conclusions: Noninvasive SWI evaluation of diastolic myocardial stiffness can differentiate between stiff, noncompliant infarcted wall and softer wall containing stunned myocardium., (Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)

Published
2016
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