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Feasibility of Imaging and Treatment Monitoring of Breast Lesions with Three-Dimensional Shear Wave Elastography.
- Source :
-
Ultraschall in der Medizin (Stuttgart, Germany : 1980) [Ultraschall Med] 2017 Jan; Vol. 38 (1), pp. 51-59. Date of Electronic Publication: 2015 Mar 05. - Publication Year :
- 2017
-
Abstract
- Purpose Firstly to evaluate the feasibility and diagnostic performance of three-dimensional (3 D) shear wave elastography (SWE) volume measurements in patients with breast lesions compared to breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) lesion volumes and 3D-US B-mode volumes. Secondly to assess the treatment monitoring performance of 3D-SWE in patients under neoadjuvant chemotherapy for breast cancer by comparing it to 3D-US lesion volume. Materials and Methods This prospective study was approved by the institutional review board. Informed consent was provided. 33 patients with 33 lesions were included. The feasibility of 3D-SWE was evaluated in 23 patients. In the 10 remaining patients receiving neoadjuvant chemotherapy, 3D-SWE was evaluated before and during treatment. Tumor volume and qualitative and quantitative elasticity analysis measurements were performed and compared to the tumor volume as estimated by 3D-US and DCE-MRI. Statistical analysis was performed using the Pearson correlation coefficient. Results 3D-SWE was feasible in patients with breast lesions. Tumor volume calculated with 3D-US and 3D-SWE showed very good and moderate concordances with DCE-MRI volume, respectively (Pearson correlation coefficients equal to ρ = r = 0.88, p < 0.00 002 and ρ = r = 0.5, p = 0.32, respectively). Modification of tumor elasticity and heterogeneity was correlated with response to treatment. In good responders, elasticity and elasticity heterogeneity diminished. Conclusion Tumor 3D-US volume measurements showed very good concordance with DCE-MRI volume. 3D-SWE can provide valuable information: reduction of tissue stiffness during treatment could be a potential indicator of response. These preliminary results should be confirmed on a larger number of patients.<br /> (© Georg Thieme Verlag KG Stuttgart · New York.)
- Subjects :
- Adult
Aged
Breast Neoplasms drug therapy
Chemotherapy, Adjuvant
Feasibility Studies
Humans
Magnetic Resonance Imaging methods
Mammography methods
Middle Aged
Neoadjuvant Therapy
Prospective Studies
Treatment Outcome
Tumor Burden physiology
Breast Neoplasms diagnostic imaging
Elasticity Imaging Techniques methods
Imaging, Three-Dimensional methods
Ultrasonography, Mammary methods
Subjects
Details
- Language :
- English
- ISSN :
- 1438-8782
- Volume :
- 38
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Ultraschall in der Medizin (Stuttgart, Germany : 1980)
- Publication Type :
- Academic Journal
- Accession number :
- 25741668
- Full Text :
- https://doi.org/10.1055/s-0034-1398980