131 results on '"Sun Jin Boo"'
Search Results
2. Antineutrophil cytoplasmic antibody–negative pauci-immune glomerulonephritis with massive intestinal bleeding
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Miyeon Kim, Young Uck Kim, Sun Jin Boo, So Mi Kim, and Hyun Woo Kim
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Gastrointestinal hemorrhage ,Glomerulonephritis ,Vasculitis ,Internal medicine ,RC31-1245 ,Specialties of internal medicine ,RC581-951 - Abstract
A 61-year-old woman was admitted to hospital because of generalized edema and proteinuria. Her renal function deteriorated rapidly. Serum immunoglobulin and complement levels were within normal ranges. An autoantibody examination showed negative for antinuclear antibody and antineutrophil cytoplasmic antibody. Histologic examination of a renal biopsy specimen revealed that all of the glomeruli had severe crescent formations with no immune deposits. The patient was treated with steroid pulse therapy with cyclophosphamide followed by oral prednisolone. Fifteen days later, she experienced massive recurrent hematochezia. Angiography revealed an active contrast extravasation in a branch of the distal ileal artery. We selectively embolized with a permanent embolic agent. On the 45th hospital day, the patient suddenly lost consciousness. Brain computed tomography showed intracerebral hemorrhage. We report a case of antineutrophil cytoplasmic antibody–negative pauci-immune glomerulonephritis with massive intestinal bleeding and cerebral hemorrhage.
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- 2015
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3. Gluteal and Presacral Abscess Due to Crohn’s Disease with Multiple Fistulas
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Hyun Joo Song, Hogyung Jun, Seong Taeg Kim, Sun-Jin Boo, Heung Up Kim, and Donghyoun Lee
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crohn disease ,abscess ,infliximab ,Medicine - Abstract
The abscess is a common complication of Crohn’s disease (CD), with the perianal form more frequent than gluteal or presacral which is relatively rare. There are few case reports of gluteal abscess combined with presacral abscess caused by CD and the treatment has not been established. A 21-year-old male was admitted with right buttock and lower back pain with a duration of 3 months. He had a history of CD in the small intestine diagnosed 10 months previously. He had poor compliance and had not returned for follow-up care during the previous 6 months. Abdominopelvic CT indicated newly developed multiple abscess pockets in right gluteal region, including piriformis muscle and presacral space. Additionally, fistula tracts between small bowel loops and presacral space were observed. Patient’s CD was moderate activity (273.12 on the Crohn’s Disease Activity Index [CDAI]). Treatment was started with piperacillin/ tazobactam antibiotic but patient developed a fever and abscess extent was aggravated. Therefore, surgical incision and drainage was performed and 4 Penrose drains were inserted. Patient’s pain and fever were resolved following surgery. Infliximab was then administered for the remaining fistulas. After the induction regimen, multiple fistula tracts improved and patient went into remission (CDAI was -0.12).
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- 2024
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4. Thirty-year Trend in Inflammatory Bowel Disease on Jeju Island, South Korea
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Jin Woo Kim, Hyun Joo Song, Sun-Jin Boo, Heung Up Kim, Ki Soo Kang, and Soo-Young Na
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inflammatory bowel disease ,crohn’s disease ,ulcerative colitis ,incidence ,prevalence ,Medicine - Abstract
Background/Aims: Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is increasing in South Korea. On the other hand, there are no reports of the incidence and prevalence of IBD specific to Jeju Island, prompting the necessity of this study. Methods: In this retrospective design, the medical records of 453 patients diagnosed with IBD at Jeju National University Hospital from January 1990 to December 2019 were analyzed. Results: Of the 453 IBD subjects (165 CD, 288 UC) included, the UC: CD ratio was 1.75:1. The incidence of IBD increased continuously from 0.19/105 in 1990 to 6.39/105 in 2017 and after that decreased to 4.92/105 in 2019. The male:female ratio was 2.24:1 for CD and 1.29:1 for UC. In the CD subjects, the disease activity included remission (33.3%), mild (25.5%), moderate (30.9%), and severe (6.1%). In UC subjects, the disease activity included remission (24.0%), mild (35.4%), moderate (28.8%), and severe (6.2%). According to the Montreal classification, the cases were as follows: CD: terminal ileum (22.4%), colon (9.7%), ileocolon (66.1%), and upper gastrointestinal involvement (27.3%), and perianal fistula/abscess was present in 43.6% of subjects before or at diagnosis: UC: proctitis (43.4%), left-sided colitis (29.1%), and pancolitis (23.3%) at diagnosis. Conclusions: The incidence of IBD on Jeju Island has increased steadily for approximately 30 years but has exhibited a decline since 2017. Therefore, the incidence of IBD in Jeju is believed to have plateaued. Further study will be needed for clarification.
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- 2023
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5. Korean Guidelines for Postpolypectomy Colonoscopic Surveillance: 2022 revised edition
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Su Young Kim, Min Seob Kwak, Soon Man Yoon, Yunho Jung, Jong Wook Kim, Sun-Jin Boo, Eun Hye Oh, Seong Ran Jeon, Seung-Joo Nam, Seon-Young Park, Soo-Kyung Park, Jaeyoung Chun, Dong Hoon Baek, Mi-Young Choi, Suyeon Park, Jeong-Sik Byeon, Hyung Kil Kim, Joo Young Cho, Moon Sung Lee, and Oh Young Lee
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colonoscopy ,colorectal cancer ,guidelines ,polypectomy ,surveillance ,Medicine ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Colonoscopic polypectomy is effective in decreasing the incidence and mortality of colorectal cancer (CRC). Premalignant polyps discovered during colonoscopy are associated with the risk of metachronous advanced neoplasia. Postpolypectomy surveillance is the most important method for managing advanced metachronous neoplasia. A more efficient and evidence-based guideline for postpolypectomy surveillance is required because of the limited medical resources and concerns regarding colonoscopy complications. In these consensus guidelines, an analytic approach was used to address all reliable evidence to interpret the predictors of CRC or advanced neoplasia during surveillance colonoscopy. The key recommendations state that the high-risk findings for metachronous CRC following polypectomy are as follows: adenoma ≥10 mm in size; 3 to 5 (or more) adenomas; tubulovillous or villous adenoma; adenoma containing high-grade dysplasia; traditional serrated adenoma; sessile serrated lesion containing any grade of dysplasia; serrated polyp of at least 10 mm in size; and 3 to 5 (or more) sessile serrated lesions. More studies are needed to fully comprehend the patients who are most likely to benefit from surveillance colonoscopy and the ideal surveillance interval to prevent metachronous CRC.
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- 2023
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6. Korean guidelines for postpolypectomy colonoscopic surveillance: 2022 revised edition
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Su Young Kim, Min Seob Kwak, Soon Man Yoon, Yunho Jung, Jong Wook Kim, Sun-Jin Boo, Eun Hye Oh, Seong Ran Jeon, Seung-Joo Nam, Seon-Young Park, Soo-Kyung Park, Jaeyoung Chun, Dong Hoon Baek, Mi-Young Choi, Suyeon Park, Jeong-Sik Byeon, Hyung Kil Kim, Joo Young Cho, Moon Sung Lee, and Oh Young Lee
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colonoscopy ,colorectal cancer ,guidelines ,polypectomy ,surveillance ,Internal medicine ,RC31-1245 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Colonoscopic polypectomy is effective in decreasing the incidence and mortality of colorectal cancer (CRC). Premalignant polyps discovered during colonoscopy are associated with the risk of metachronous advanced neoplasia. Postpolypectomy surveillance is the most important method for the management of advanced metachronous neoplasia. A more efficient and evidence-based guideline for postpolypectomy surveillance is required because of limited medical resources and concerns regarding colonoscopy complications. In these consensus guidelines, an analytic approach was used to address all reliable evidence to interpret the predictors of CRC or advanced neoplasia during surveillance colonoscopy. The key recommendations state that the high-risk findings for metachronous CRC following polypectomy are as follows: (1) adenoma ≥10 mm in size; (2) 3 to 5 (or more) adenomas; (3) tubulovillous or villous adenoma; (4) adenoma containing high-grade dysplasia; (5) traditional serrated adenoma; (6) sessile serrated lesion (SSL) containing any grade of dysplasia; (7) serrated polyp of at least 10 mm in size; and (8) 3 to 5 (or more) SSLs. More studies are needed to fully comprehend the patients most likely to benefit from surveillance colonoscopy and the ideal surveillance interval to prevent metachronous CRC.
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- 2022
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7. Colonic cryptococcosis presenting with chronic diarrhea in a person with advanced human immunodeficiency virus disease: a case report
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Hyunjoo Oh, Misun Kim, Jeong Rae Yoo, Sun-Jin Boo, and Sang Taek Heo
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cryptococcosis ,gastrointestinal tract ,diarrhea ,hiv ,acquired immune deficiency syndrome ,Medicine - Abstract
Cryptococcus neoformans infection usually occurs in patients with advanced human immunodeficiency virus (HIV) infection or with a CD4 T lymphocyte count of
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- 2022
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8. The Efficacy of Gastric Per-oral Endoscopic Myotomy for Refractory Gastroparesis
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Sun-Jin Boo
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Medicine - Published
- 2022
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9. Are Proton Pump Inhibitors a Risk Factor for Gastric Cancer?
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Sun-Jin Boo
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Medicine - Published
- 2022
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10. Acute Ischemic Gastropathy with Portal Venous Gas
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Jae Joon Lee, Jeong Sub Lee, and Sun-Jin Boo
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Medicine - Published
- 2021
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11. Gluteal and Presacral Abscess Due to Crohn’s Disease with Multiple Fistulas
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Hui Jeong Jwa, Hyun Joo Song, Hogyung Jun, Seong Taeg Kim, Sun-Jin Boo, Heung Up Kim, and Donghyoun Lee
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General Medicine - Published
- 2022
12. Comparative Study of Autophagy in Oxaliplatin-Sensitive and Resistant SNU-C5 Colon Cancer Cells
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Sun-Jin, Boo, Mei Jing, Piao, Kyoung Ah, Kang, Ao Xuan, Zhen, Pincha Devage Sameera Madushan, Fernando, Herath Mudiyanselage Udari Lakmini, Herath, Seung Joo, Lee, Seung Eun, Song, and Jin Won, Hyun
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Pharmacology ,Drug Discovery ,Molecular Medicine ,Biochemistry - Abstract
Few studies have evaluated the role of autophagy in the development of oxaliplatin (OXT) resistance in colon cancer cells. In this study, we compared the role of autophagy between SNU-C5 colon cancer cells and OXT-resistant SNU-C5 (SNU-C5/OXTR) cells. At the same concentration of OXT, the cytotoxicity of OXT or apoptosis was significantly reduced in SNU-C5/OXTR cells compared with that in SNU-C5 cells. Compared with SNU-C5 cells, SNU-C5/OXTR cells exhibited low levels of autophagy. The expression level of important autophagy proteins, such as autophagy-related protein 5 (Atg5), beclin-1, Atg7, microtubule-associated proteins 1A/1B light chain 3B I (LC3-I), and LC3-II, was significantly lower in SNU-C5/OXTR cells than that in SNU-C5 cells. The expression level of the autophagy-essential protein p62 was also lower in SNU-C5/OXTR cells than in SNU-C5 cells. In SNUC5/ OXTR cells, the production of intracellular reactive oxygen species (ROS) was significantly higher than that in SNU-C5 cells, and treatment with the ROS scavenger N-acetylcysteine restored the reduced autophagy levels. Furthermore, the expression of antioxidant-related nuclear factor erythroid 2-related factor 2 transcription factor, heme oxygenase-1, and Cu/Zn superoxide dismutase were also significantly increased in SNU-C5/OXTR cells. These findings suggest that autophagy is significantly reduced in SNU-C5/OXTR cells compared with SNU-C5 cells, which may be related to the production of ROS in OXT-resistant cells.
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- 2022
13. COVID-19 from the Perspective of a Gastroenterologist
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Sun-Jin Boo
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medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pneumonia, Viral ,gastroenterology ,lcsh:Medicine ,Peptidyl-Dipeptidase A ,pandemics ,medicine.disease_cause ,Gastroenterology ,Betacoronavirus ,Internal medicine ,Pandemic ,medicine ,Humans ,Endoscopy, Digestive System ,China ,Coronavirus ,SARS-CoV-2 ,business.industry ,Gastroenterologists ,lcsh:R ,Perspective (graphical) ,Outbreak ,General Medicine ,medicine.disease ,Contagious disease ,Gastrointestinal Tract ,covid-19 ,Angiotensin-Converting Enzyme 2 ,Coronavirus Infections ,business - Abstract
The World Health Organization (WHO) declared the worldwide pandemic of Coronavirus disease-2019 (COVID-19) On March 11, 2020, just three months after the first outbreak of COVID-19 caused by Severe Acute Respiratory Syndrome Coronavirus 2 in China in December 2019. COVID-19 is a contagious disease that can affect anyone, anytime, anywhere, and has had a huge impact on our lives, including social, economic, educational, and cultural life. In this paper, I would like to explore the issues related to COVID-19 in the gastroenterology and share the experiences of domestic and overseas gastroenterologists, and ultimately to seek ways to effectively prepare for and cope with the pandemic era of COVID-19.
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- 2020
14. UPPER GASTROINTESTINAL INVOLVEMENT OF BEHCET'S DISEASE
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Hogyung Jun, Hyun Joo Song, Sun-Jin Boo, and Heung Up Kim
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Gastroenterology ,Radiology, Nuclear Medicine and imaging - Published
- 2022
15. Risk of Metachronous Colorectal Advanced Neoplasia and Cancer in Patients With 3-4 Nonadvanced Adenomas at Index Colonoscopy: A Systematic Review and Meta-Analysis
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Suyeon Park, Seong Ran Jeon, Hyun Gun Kim, Yunho Jung, Min-Seob Kwak, Su Young Kim, Jong Wook Kim, Seung-Joo Nam, Eun Hye Oh, Seon-Young Park, Soo-Kyung Park, Jeong-Sik Byeon, Sun-Jin Boo, Dong Hoon Baek, Soon Man Yoon, Jaeyoung Chun, Jooyoung Lee, and Miyoung Choi
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Adenoma ,Hepatology ,Risk Factors ,Gastroenterology ,Colonic Polyps ,Humans ,Neoplasms, Second Primary ,Colonoscopy ,Colorectal Neoplasms - Abstract
This systematic review and meta-analysis evaluated the available evidence on the risk of metachronous advanced neoplasia (AN) and colorectal cancer (CRC) in patients with 3-4 nonadvanced adenomas (NAAs).We searched MEDLINE, EMBASE, and Cochrane Library databases up to January 2021 for studies evaluating metachronous AN and CRC risk by comparing 3 groups (1-2 vs 3-4 vs ≥5 NAAs) at index colonoscopy. The estimates for risk of metachronous AN and CRC were evaluated using random-effects models.Fifteen studies (n = 36,375) were included. The risk of metachronous AN was significantly higher in the 3-4 NAAs group than in the 1-2 NAAs group (relative risk [RR] 1.264, 95% confidence interval [CI] 1.053-1.518, P = 0.012; I2 = 0%); there was no difference between the ≥ 5 NAAs and 3-4 NAAs groups (RR 1.962, 95% CI 0.972-3.958, P = 0.060; I2 = 68%). The risks of metachronous CRC between the 1-2 NAAs and 3-4 NAAs groups (RR 2.663, 95% CI 0.391-18.128, P = 0.317; I2 = 0%) or the 3-4 NAAs and ≥ 5 NAAs groups (RR 1.148, 95% CI 0.142-9.290, P = 0.897; I2 = 0%) were not significantly different.Although the risk of metachronous AN was greater in the 3-4 NAAs group than in the 1-2 NAAs group, the risk of metachronous AN and CRC between the 3-4 NAAs and ≥ 5 NAAs groups was not different. This suggests that further studies on metachronous AN and CRC risk in the 3-4 NAAs group are warranted to confirm a firm ≥5-year interval surveillance colonoscopy.
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- 2021
16. Comparison of Peroral Endoscopic Myotomy and Laparoscopic Heller's Myotomy for Treatment of Idiopathic Achalasia: A Prospective, Multicenter, Randomized Study
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Sun-Jin Boo
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Myotomy ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,lcsh:R ,lcsh:Medicine ,General Medicine ,Surgery ,law.invention ,Randomized controlled trial ,law ,Medicine ,Idiopathic achalasia ,business - Published
- 2020
17. Embedded Fish Bone in the Upper Esophageal Sphincter that Was Localized and Removed Using Ultrasonography-guided Surgery
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Seung Yeon Cho, Sun-Jin Boo, Gil Chai Lim, and Heung Up Kim
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medicine.medical_specialty ,Foreign bodies ,lcsh:Internal medicine ,business.industry ,Pharynx ,Surgery ,Upper esophageal sphincter ,medicine.anatomical_structure ,Medicine ,Fish bone ,Ultrasonography ,business ,lcsh:RC31-1245 ,Foreign Bodies - Abstract
The prevalence of people presenting with fish bone foreign body (FFB) is high in Asian countries, including Korea, and coastal areas around the world. Pointed linear-shaped FFBs are common in the oral cavity and upper esophageal sphincter, whereas large flat bones are more common FFBs in the esophagus. If the FFB is not found on endoscopy, residual foreign body sensation or embedded FFB is possible. In such cases, CT is helpful. However, in the case of totally embedded FFB, not only preoperative diagnosis but also localization during operation or surgery is important. If these are not performed, the initial incision site or operation method would be difficult to determine. For this purpose, no standard guideline has been established yet. We report a case of upper esophageal sphincter-embedded FFB diagnosed using CT rather than endoscopy. The bone was successfully localized using conventional ultrasonography during the operation and then removed surgically.
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- 2019
18. An Adjusted Level of Adenoma Detection Rate is Necessary for Adults Below 50 Years Old
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Jun Lee, Jin Young Yoon, Hoon Sup Koo, Young Eun Joo, Hyo Joon Yang, Sun Jin Boo, Hyun Jung Lee, Yunho Jung, Kyeong Ok Kim, Jeong Eun Shin, Young Seok Cho, Jae Myung Cha, and Hyun Gun Kim
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Adenoma ,Adult ,Male ,medicine.medical_specialty ,Colonoscopy ,Subgroup analysis ,Asymptomatic ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Republic of Korea ,Prevalence ,medicine ,Humans ,Mass Screening ,Young adult ,Early Detection of Cancer ,Mass screening ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Endoscopy ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,medicine.symptom ,Colorectal Neoplasms ,business - Abstract
BACKGROUND Although adenoma prevalence is lower in younger people compared with screening-aged adults 50 years old and above, there is no adjustment recommendation for the target adenoma detection rate (ADR) in young people. Herein, we estimated a different target ADR for adults below 50 years old based on screening colonoscopy findings. MATERIALS AND METHODS Asymptomatic, average-risk adults below 50 years old who underwent screening colonoscopy were enrolled at 12 endoscopy centers in Korea between February 2006 and March 2012. Screening colonoscopies were stratified into low or high ADR groups with ADR levels of 20% and 25%, respectively. RESULTS The ADRs from 12 endoscopy centers ranged from 12.1% to 43.8% (median ADR, 24.1%) based on 5272 young adults receiving screening colonoscopies. Using 20% as an ADR level, the risks for metachronous adenoma and advanced adenoma were significantly higher in the low ADR group than the high ADR group (35.4% vs. 25.7%, P
- Published
- 2018
19. Impact of Endoscopists' Personality Traits on Adenoma and Polyp Detection Rates in Colonoscopy: A KASID Multicenter Study
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Mee Jung Han, Jae Myung Cha, Kyu Chan Huh, Hyun Gun Kim, Yunho Jung, Jong Wook Kim, Soo-Young Na, Kyeong Ok Kim, Jeong Eun Shin, Seong Ran Jeon, Na-Hyun Lee, Sun-Jin Boo, Jae Hyun Kim, Jun Lee, Young Hwangbo, Yoo Jin Lee, Young-Eun Joo, and Hyo-Joon Yang
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Adenoma ,Male ,medicine.medical_specialty ,Physiology ,media_common.quotation_subject ,Colonoscopy ,Colonic Polyps ,Withdrawal time ,Logistic regression ,Asymptomatic ,03 medical and health sciences ,0302 clinical medicine ,Minnesota Multiphasic Personality Inventory ,MMPI ,Internal medicine ,medicine ,Personality ,Humans ,media_common ,Aged ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Gastroenterologists ,Gastroenterology ,Middle Aged ,medicine.disease ,Colon polyps ,030220 oncology & carcinogenesis ,Colonic Neoplasms ,030211 gastroenterology & hepatology ,Female ,medicine.symptom ,business - Abstract
The personality traits of endoscopists have been suggested to affect the adenoma detection rate (ADR). We thus evaluated the relationship between endoscopists’ personality traits and the ADR during colonoscopy using the Minnesota Multiphasic Personality Inventory-2 (MMPI-2). In total, 1230 patients (asymptomatic and aged 50–80 years) who underwent screening or surveillance (≥ 5 years) colonoscopy were recruited from 13 university hospitals by 20 endoscopists between September 2015 and December 2017. We retrospectively measured the ADR, polyp detection rate (PDR), and number of adenomas per colonoscopy (APC). All 20 endoscopists completed all 567 true/false MMPI-2 items. The overall mean colonoscopy withdrawal time, PDR, ADR, and APC were 7.3 ± 2.8 min, 55%, 45.3%, and 0.97 ± 1.58, respectively. No significant difference was observed in the MMPI-2 clinical scales (e.g., hypochondriasis and psychasthenia), content scales (e.g., obsessiveness and type A character), or supplementary scales (e.g., dominance and social responsibility) between the high ADR group (ADR ≥45%, n = 10) and the low ADR group (ADR
- Published
- 2019
20. Factors Predictive of Complete Excision of Large Colorectal Neoplasia Using Hybrid Endoscopic Submucosal Dissection: A KASID Multicenter Study
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Jeong Sik Byeon, Yoon Mi Jeen, Hoon Sup Koo, Yunho Jung, Jun Lee, Young Hwangbo, Jong Wook Kim, Sun‑Jin Boo, and Hyun Gun Kim
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Male ,medicine.medical_specialty ,Endoscopic Mucosal Resection ,Physiology ,Endoscopic mucosal resection ,Risk Assessment ,Complete resection ,03 medical and health sciences ,0302 clinical medicine ,Transplant surgery ,Internal medicine ,Outcome Assessment, Health Care ,Republic of Korea ,medicine ,Humans ,Prospective Studies ,Intestinal Mucosa ,Aged ,business.industry ,Gastroenterology ,En bloc resection ,Endoscopic submucosal dissection ,Middle Aged ,Hepatology ,Surgery ,Treatment Outcome ,Multicenter study ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Colorectal Neoplasms ,business - Abstract
Endoscopic submucosal dissection (ESD) with snaring (hybrid ESD) bridges the gap between ESD and endoscopic mucosal resection. We evaluated factors predictive of en bloc and complete resection of large colorectal neoplasms using hybrid ESD.This was a prospective clinical study of 78 patients who underwent hybrid ESD for excision of colorectal neoplasms (≥ 2 cm) between May 2015 and September 2016 at six university hospitals. We evaluated lesion and patient characteristics, endoscopist experience level ( 50 or ≥ 50 cases with colorectal ESD), and technical factors such as concurrent fibrosis, completion of a circumferential incision, degree of submucosal dissection ( 50 or ≥ 50%), and visualization during snaring ( 50 or ≥ 50%).Multivariate analyses showed that the en bloc resection rate was significantly related to the degree of visualization during snaring (odds ratio (OR) 7.811, 95% confidence interval [CI] 1.722-35.426; p = 0.008) and the presence of fibrosis (OR 0.258, 95% CI 0.68-0.993; p = 0.049). The complete resection rate was significantly related to the colorectal ESD endoscopist skill level (OR 5.626, 95% CI 1.485-21.313; p = 0.011) and gross lesion type (OR 0.145, 95% CI 0.022-0.936; p = 0.042). When all three technical factors, i.e., completion of circumferential incision, ≥ 50% submucosal dissection, and ≥ 50% visualization during snaring, were satisfied performing hybrid ESD, the en bloc resection rate (87.5%) was similar to that of ESD.Visualization during snaring, presence of fibrosis, gross lesion type, and endoscopist colorectal ESD experience level affect en bloc or complete resection of large colorectal neoplasia using hybrid ESD.
- Published
- 2018
21. A Study on Relationship with Perceived Festival Environmental Cues by Foreign Tourists, Festival Effect, and Festival Satisfaction: Focused on the Tripitaka Koreana Festival 2017
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Sun Jin Boo
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Advertising ,Psychology ,Sensory cue - Published
- 2018
22. In Vivo Endoscopic Removal of Ancylostoma duodenale in a Patient with Abdominal Pain
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Seung Uk Jeong, Byung-Cheol Song, Heung Up Kim, Sun Jin Boo, Hyun Joo Song, Eun Kwang Choi, Young Ree Kim, and Soo Young Na
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medicine.medical_specialty ,Abdominal pain ,Hookworm ,lcsh:Internal medicine ,Ancylostoma ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,In vivo ,Internal medicine ,parasitic diseases ,medicine ,030212 general & internal medicine ,lcsh:RC31-1245 ,medicine.diagnostic_test ,biology ,business.industry ,Endoscopy ,biology.organism_classification ,Parasitic diseases ,Ancylostoma duodenale ,030211 gastroenterology & hepatology ,medicine.symptom ,business - Abstract
A 20-year-old Cambodian male living in Korea for 2 years as a foreign worker visited our gastroenterology outpatient clinic. He had a small farm in Cambodia. He complained of postprandial upper abdominal pain with nausea and vomiting for 2 years. Gastroduodenoscopy showed hyperemic mucosa near the major papilla in the duodenum and two small and slender reddish worms. These were removed with endoscopic biopsy forceps. Under microscopy, these were identified as Ancylostoma duodenale by the characteristic morphology of 2 pairs of cutting teeth in the buccal cavity and 3 lobes in the copulatory bursa. After removal of two worms, his symptom improved. Soil-transmitted helminths (STH) present a global health problem. In the Republic of Korea, STH, including hookworms, were highly prevalent until the 1970s. With mass fecal examination followed by selective mass chemotherapy with anthelmintics from 1969 to 1995, the prevalence of STH has rapidly decreased since the 1980s. Since 2004, no hookworms have been found in nationwide surveys on the prevalence of intestinal parasitic infection. Therefore, we report a case of in vivo endoscopic removal of A. duodenale in a patient with abdominal pain.
- Published
- 2018
23. Acute Phlegmonous Esophagogastritis
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Yeon Namgung, Tae-Hoon Kim, Sun Young Jeong, and Sun-Jin Boo
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medicine.medical_specialty ,business.industry ,lcsh:R ,Medicine ,lcsh:Medicine ,General Medicine ,business ,Dermatology - Published
- 2019
24. Risks of colorectal advanced neoplasia in young adults versus those of screening colonoscopy in patients aged 50 to 54 years
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Young Eun Joo, Jun Lee, Kyeong Ok Kim, Jeong Eun Shin, Jongha Park, Yunho Jung, Hyo Joon Yang, Hyun Jung Lee, Young Seok Cho, Jae Myung Cha, Kyu Chan Huh, Hyun Gun Kim, Chang Mo Moon, and Sun Jin Boo
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Oncology ,medicine.medical_specialty ,Hepatology ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Colonoscopy ,Retrospective cohort study ,Screening colonoscopy ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,Cohort ,medicine ,030211 gastroenterology & hepatology ,In patient ,Young adult ,business ,Mass screening ,Cohort study - Abstract
Background and Aim The role of screening or diagnostic colonoscopy to detect advanced neoplasia in young cohorts of age
- Published
- 2017
25. Higher body mass index is associated with an increased risk of multiplicity in surveillance colonoscopy within 5 years
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Sung Chul Park, Chung Hyun Tae, Geom Seog Seo, Young Eun Joo, Yunho Jung, Jae Jun Park, Jin Oh Kim, Chang Soo Eun, Dong Il Park, Hyun Jung Lee, Jae Myung Cha, Jaeyoung Chun, Sung Ae Jung, Chang Mo Moon, and Sun Jin Boo
- Subjects
Adenoma ,Male ,medicine.medical_specialty ,Multivariate analysis ,lcsh:Medicine ,Overweight ,Article ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Medicine ,Humans ,Obesity ,lcsh:Science ,Retrospective Studies ,Multidisciplinary ,business.industry ,Incidence (epidemiology) ,lcsh:R ,Colonoscopy ,Middle Aged ,medicine.disease ,Increased risk ,030220 oncology & carcinogenesis ,Epidemiological Monitoring ,030211 gastroenterology & hepatology ,Surveillance colonoscopy ,Female ,lcsh:Q ,Radiology ,medicine.symptom ,business ,Colorectal Neoplasms ,Body mass index ,Index Colonoscopy - Abstract
We aimed to evaluate whether obesity was associated with a certain clinicopathologic characteristics of metachronous CRA. This retrospective longitudinal cohort study included 2,904 subjects who had at least one resected CRA at index colonoscopy and who subsequently underwent one or more surveillance colonoscopies within 5 years. Of the 2,904 subjects, 60.9% (n = 1,769) were normal, 35.8% (n = 1,040) were overweight, and 3.3% (n = 95) were obese. Patients with any metachronous CRA were 53.7% (n = 1,559). In multivariate analyses, higher BMI at index colonoscopy was significantly associated with any metachronous CRA (overweight, OR = 1.07; obese, OR = 1.82; p for trend = 0.049). Regarding the multiplicity, the ORs of ≥ 3, ≥ 4 and ≥ 5 metachronous CRAs significantly increased as index BMI increased (p for trend p for trend = 0.016). Higher index BMI was significantly associated with the risk of multiple metachronous CRAs on surveillance colonoscopy within 5 years.
- Published
- 2017
26. Risk of advanced colorectal neoplasm in patients with more than 10 adenomas on index colonoscopy: A Korean Association for the Study of Intestinal Diseases (KASID) study
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Hyo-Joon Yang, Dong Il Park, Jae Myung Cha, Sung Wook Hwang, Young-Eun Joo, Jun Lee, Sun-Jin Boo, Soo-Kyung Park, Kyeong Ok Kim, Jeong Eun Shin, and Yunho Jung
- Subjects
medicine.medical_specialty ,endocrine system diseases ,Hepatology ,Adenoma ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Colonoscopy ,Odds ratio ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Dysplasia ,030220 oncology & carcinogenesis ,Internal medicine ,Medicine ,030211 gastroenterology & hepatology ,Risk factor ,business ,Prospective cohort study ,Cohort study ,Index Colonoscopy - Abstract
Background and Aim The number of patients with >10 adenomas is relatively small, and few studies have investigated the risk of colorectal neoplasm (CRN) in these patients. Thus, we aimed to investigate the risk of developing CRN in patients with >10 adenomas and to compare their risk with that of patients with 3–10 adenomas. Methods A retrospective multicenter cohort study that included 214 patients with >10 adenomas on index colonoscopy performed between January 2009 and December 2011, and underwent follow-up colonoscopy until December 2015 was conducted. The risk of developing advanced CRN (cancer or advanced adenoma with a diameter of ≥10 mm or with a villous component, or high-grade dysplasia) was investigated and compared with that in patients with 3–10 adenomas (n = 975). Results Among the 214 patients with >10 adenomas, the mean age was 62.9 years and the mean number of adenomas on index colonoscopy was 14.2. Overall, 57 patients (26.6%) developed an advanced CRN after a mean of 4.3 years from baseline colonoscopy. The respective 3- and 5-year cumulative risks of advanced CRN were 6.8% (95% confidence interval [CI] 2.9–10.7) and 28.7% (95% CI 20.8–36.5), higher than those in the group with 3–10 adenomas (n = 975, P = 0.001). Having >10 adenomas on index colonoscopy was an independent risk factor for developing advanced CRN (odds ratio 2.25, 95% CI 1.49–3.38). Conclusions The risk of developing advanced CRN in patients with >10 adenomas was high and statistically higher than that in patients with 3–10 adenomas. Further prospective studies are needed to investigate whether a more intensive surveillance is needed in this group.
- Published
- 2017
27. Safeness of Endoscopic Resection in Patients with End-Stage Renal Disease on Dialysis
- Author
-
Sun-Jin Boo
- Subjects
lcsh:Internal medicine ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Gastroenterology ,Medicine (miscellaneous) ,End stage renal disease ,Surgery ,Commentary ,medicine ,lcsh:Diseases of the digestive system. Gastroenterology ,Radiology, Nuclear Medicine and imaging ,In patient ,Endoscopic resection ,lcsh:RC799-869 ,lcsh:RC31-1245 ,business ,Dialysis - Published
- 2020
28. Outcomes and Management Strategies for Capsule Retention: A Korean Capsule Endoscopy Nationwide Database Registry Study
- Author
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Seong Ran Jeon, Ji Hyun Kim, Yunho Jung, Kyeong Ok Kim, Yoo Jin Lee, Sun Hyung Kang, Yun Jeong Lim, Jae Jun Park, Sun-Jin Boo, Hyun Joo Jang, Seung-Joo Nam, Jaeyoung Chun, and Hyun Seok Lee
- Subjects
Adult ,Male ,medicine.medical_specialty ,Physiology ,Registry study ,Capsule Endoscopy ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Capsule endoscopy ,law ,Internal medicine ,Intestine, Small ,Republic of Korea ,medicine ,Humans ,Registries ,Esophagus ,business.industry ,Gastroenterology ,Nationwide database ,Capsule ,Disease Management ,Hepatology ,Middle Aged ,Foreign Bodies ,Surgery ,medicine.anatomical_structure ,Treatment Outcome ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Abdominal symptoms ,business ,Complication - Abstract
The most concerning complication of capsule endoscopy (CE) is capsule retention (CR) in the gastrointestinal (GI) tract; however, the clinical outcomes and management of patients with CR are still uncertain. This study aimed to investigate the clinical outcomes and management of CR. The outcomes of CR in multiple centers between October 2002 and June 2018 were retrospectively reviewed. Data on CE indication, findings, and management details were analyzed. A total of 2705 consecutive small-bowel CE procedures were performed. CR was detected in 20 cases (0.7%). The most common site of CR was the small bowel (19 cases), followed by the esophagus (one case). In patients who underwent CE, CR was detected in nine (0.6%) of 1397 patients with obscure GI bleeding. Further, CR occurred in 11 (6.5%) of 169 patients with Crohn’s disease based on the final diagnoses after CE. Capsule retrieval was safely performed surgically in nine cases and endoscopically in six cases. The retained capsules dislodged after steroid treatment in two cases, whereas three cases of CR resolved without any intervention. In multivariate analysis, the development of abdominal symptoms after CR was a significant predictive factor for requiring endoscopic or surgical interventions for capsule extraction. This large multicenter study shows that CR is a rare complication with favorable clinical outcomes. Three-fourths of the patients with CR were managed with endoscopic or surgical intervention, which was required particularly in patients with abdominal symptoms after CR.
- Published
- 2019
29. Endoplasmic reticulum stress induces 5-fluorouracil resistance in human colon cancer cells
- Author
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Yong Joo Jeong, Seung Uk Jeong, Soo-Young Na, Sun Jin Boo, Yea Seong Ryu, Min Chang Oh, Xia Han, Mei Jing Piao, Joon Ki Kim, Jin Won Hyun, Kristina Shilnikova, Pattage Madushan Dilhara Jayatissa Fernando, Kyoung Ah Kang, and Jeong Eon Park
- Subjects
0301 basic medicine ,MAPK/ERK pathway ,Antimetabolites, Antineoplastic ,medicine.medical_specialty ,Cell Survival ,Colorectal cancer ,Health, Toxicology and Mutagenesis ,Mitochondrion ,Toxicology ,03 medical and health sciences ,0302 clinical medicine ,Cell Line, Tumor ,Internal medicine ,medicine ,Humans ,RNA, Small Interfering ,Extracellular Signal-Regulated MAP Kinases ,Endoplasmic Reticulum Chaperone BiP ,Protein kinase B ,Heat-Shock Proteins ,Pharmacology ,ATF6 ,business.industry ,Endoplasmic reticulum ,General Medicine ,Transfection ,Endoplasmic Reticulum Stress ,medicine.disease ,Activating Transcription Factor 6 ,Mitochondria ,030104 developmental biology ,Endocrinology ,Drug Resistance, Neoplasm ,Gene Knockdown Techniques ,030220 oncology & carcinogenesis ,Colonic Neoplasms ,Unfolded protein response ,Cancer research ,Calcium ,Fluorouracil ,business ,Proto-Oncogene Proteins c-akt - Abstract
Colon cancer can be treated with 5-fluorouracil (5-FU), but 5-FU resistance frequently occurs. We determined whether 5-FU resistance arises as a result of endoplasmic reticulum (ER) stress. 5-FU-resistant SNUC5 colon cancer cells (SNUC5/FUR cells) expressed higher levels of ER stress-related proteins than drug-sensitive SNUC5 cells. SNUC5/FUR cells also exhibited more intense ER staining and higher level of mitochondrial Ca(2+) overload. SNUC5/FUR cells transfected with siRNA against GRP78, ATF6, ERK, or AKT were more sensitive to 5-FU than siControl RNA-transfected cells. These results suggested that 5-FU resistance was associated with ER stress in colon cancer.
- Published
- 2016
30. [Esophageal Foreign Body: Treatment and Complications]
- Author
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Heung Up Kim and Sun Jin Boo
- Subjects
medicine.medical_specialty ,Complications ,Fistula ,Perforation (oil well) ,lcsh:Medicine ,03 medical and health sciences ,0302 clinical medicine ,Esophagus ,medicine ,Humans ,Pneumomediastinum ,Abscess ,Esophageal Perforation ,business.industry ,lcsh:R ,General Medicine ,medicine.disease ,Foreign Bodies ,Mediastinitis ,Surgery ,medicine.anatomical_structure ,Pneumothorax ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Therapy ,Esophagoscopy ,medicine.symptom ,business ,Tomography, X-Ray Computed ,Subcutaneous emphysema - Abstract
The most common cause of esophageal foreign bodies in adults is meat in Western countries and fish bones in Asian countries, including Korea. Although most ingested foreign bodies pass spontaneously through the esophagus without any clinical sequelae, some sharp foreign bodies, such as fish bones embedded in the esophagus, require treatment. Endoscopic management is the first choice in the treatment of esophageal foreign bodies because it is quite safe and effective. Major complications occur as a result of esophageal perforation; in particular, sharp foreign bodies, such as fish bones, are more likely to cause perforation. Complications include mediastinitis, paraesophageal abscess, pneumomediastinum, subcutaneous emphysema, pneumothorax, tracheoesophagal fistula, aortoesophageal fistula, aspiration, and asphyxia. Unnecessary delays should be avoided in endoscopic intervention for esophageal foreign bodies to prevent complications.
- Published
- 2018
31. Correction to: Factors Predictive of Complete Excision of Large Colorectal Neoplasia Using Hybrid Endoscopic Submucosal Dissection: A KASID Multicenter Study
- Author
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Yunho Jung, Jong Wook Kim, Jeong‑Sik Byeon, Hoon Sup Koo, Sun‑Jin Boo, Jun Lee, Young Hwangbo, Yoon Mi Jeen, and Hyun Gun Kim
- Subjects
Physiology ,Gastroenterology - Abstract
The original version of the article unfortunately contained errors in author affiliation. Affiliation of third and ninth author was incorrectly assigned.
- Published
- 2018
32. An adequate level of training for technically competent colonoscopic polypectomy
- Author
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Dong-Hoon Yang, Seung-Jae Myung, Sang Hyoung Park, Kyung-Jo Kim, Jae Ho Park, Jin-Ho Kim, Ji Hoon Jung, Jeong-Sik Byeon, Suk-Kyun Yang, Sun-Jin Boo, Byong Duk Ye, Seon-Ok Kim, and Soo-Young Na
- Subjects
Male ,medicine.medical_specialty ,business.industry ,General surgery ,Operative Time ,Gastroenterology ,Colonic Polyps ,Colonoscopy ,Middle Aged ,Surgery ,Learning curve ,Multivariate Analysis ,medicine ,Humans ,Colonoscopic Polypectomy ,Female ,Clinical Competence ,business ,Colectomy ,Learning Curve ,Aged - Abstract
The purpose of this study is to investigate the learning curve for colonoscopic polypectomy (CP) by trainee endoscopists.The amount of training required to achieve technical competence for CP is uncertain.The CP times and en bloc resection rates of three experienced colonoscopists were obtained from 240 procedures. These data were compared to those of three gastroenterology trainees who performed 750 CP procedures. A trainee procedure was deemed to be a success if en bloc resection was obtained and the CP time was within twice the median CP time of the experienced colonoscopists. Trainees were deemed to be technically competent when they achieved a CP success rate of greater than or equal to 80%.The median CP times and en bloc resection rates for the experienced colonoscopists and trainees were 79 s (range, 20-301 s) and 99.6% (239/240), and 118 s (range, 36-1051 s) and 95.6% (717/750), respectively. The trainee success rate of CP was 72% (540/750). The success rate of the procedure was associated with increased trainee experience (p = 0.003) and reached 80% after 250 procedures. The CP time significantly decreased (p0.001) and en bloc resection rate significantly increased (p = 0.011) as trainee experience accumulated. The level of experience was an independent predictor for successful CP.The achievement of technical competence with CP was associated with an accumulation of approximately 250 procedures. These findings suggest that dedicated education and training programs for CP are warranted.
- Published
- 2015
33. A patient with Crohn's disease in remission after azathioprine induced severe myelosuppression
- Author
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Sun-Jin Boo and Eun Kwang Choi
- Abstract
Azathioprine (AZA) is widely used to maintain clinical remission of Crohn’s disease. AZA is also important as a steroidsparingagent in steroid-dependent and active Crohn’s disease. Bone marrow suppression is common adverse effect ofAZA. We report a case of a 16-year-old male patient who was diagnosed as Crohn’s disease with involvement of terminalileum and colon; he experienced clinical and endoscopic remission of Crohn’s disease following improvement of AZAinduced life-threatening myelosuppression and pancreatitis.
- Published
- 2014
34. Risk of metachronous neoplasia on surveillance colonoscopy in young patients with colorectal neoplasia
- Author
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Kyeong Ok Kim, Jeong Eun Shin, Young-Seok Cho, Young-Eun Joo, Sun-Jin Boo, Hoon Sup Koo, Hyun Gun Kim, Jae Myung Cha, and Hyo-Joon Yang
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adenoma ,Colon ,Colonoscopy ,Risk Assessment ,03 medical and health sciences ,0302 clinical medicine ,Older patients ,Risk Factors ,Internal medicine ,Republic of Korea ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Family history ,Early Detection of Cancer ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,General surgery ,Incidence (epidemiology) ,Incidence ,Gastroenterology ,Rectum ,Retrospective cohort study ,Middle Aged ,medicine.disease ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Surveillance colonoscopy ,Female ,Baseline Colonoscopy ,business ,Colorectal Neoplasms - Abstract
Few prior reports exist that address the appropriate colonoscopy surveillance interval for individuals 50 years old. We compared the risk of metachronous neoplasia between younger (20-49 years) and older (50-54 years) cohorts.This multicenter retrospective cohort study compared the incidence of metachronous neoplasia in younger and older cohorts according to baseline risk stratification. Subjects were eligible if they underwent their first colonoscopy between June 2006 and May 2010 and had at least 1 or more surveillance colonoscopy up to June 2015.Among a total of 10,477 subjects who underwent baseline colonoscopy, 9722 were eligible after excluding 755 subjects. Of those 9722 subjects, 43% underwent surveillance colonoscopy. In the baseline high-risk adenoma group (n = 840), the 3-year risk of metachronous advanced neoplasia was 10.7% in the younger patients on screening colonoscopy and 8.9% in the older patients (P.1). In the baseline low-risk adenoma group (n = 1869), the 5-year risk of metachronous advanced neoplasia was 4.9% in the younger patients on screening colonoscopy and 5.1% in the older patients (P.1). Similarly, in the baseline no neoplasia group (n = 7013), the 5-year risk of metachronous advanced neoplasia was 4.1% in the younger patients on screening colonoscopy and 5.6% in the older patients (P.1).Considering the similar risk of metachronous advanced neoplasia in younger and older individuals, we suggest a 3-year surveillance interval for high-risk adenoma and a 5-year surveillance interval for low-risk adenoma in young individuals without a strong family history.
- Published
- 2017
35. Clinical utility of cytomegalovirus antigenemia assay and blood cytomegalovirus DNA PCR for cytomegaloviral colitis patients with moderate to severe ulcerative colitis
- Author
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Jeong-Sik Byeon, Jihun Kim, Jin-Ho Kim, Soo-Kyung Park, Byong Duk Ye, Dong-Hoon Yang, Suk-Kyun Yang, Sun A. Kim, Sun-Jin Boo, Jong Wook Kim, Seung-Jae Myung, Chang Lae Kim, Kyung-Jo Kim, Kee Wook Jung, and Sang Hyoung Park
- Subjects
Adult ,Male ,Moderate to severe ,medicine.medical_specialty ,medicine.medical_treatment ,Congenital cytomegalovirus infection ,Cytomegalovirus ,Polymerase Chain Reaction ,Likelihood ratios in diagnostic testing ,Gastroenterology ,law.invention ,Cytomegalovirus DNA ,law ,Internal medicine ,Humans ,Medicine ,Colitis ,Antigens, Viral ,Colectomy ,Polymerase chain reaction ,Retrospective Studies ,business.industry ,virus diseases ,General Medicine ,Middle Aged ,medicine.disease ,Ulcerative colitis ,ROC Curve ,Area Under Curve ,Cytomegalovirus Infections ,DNA, Viral ,Immunology ,Colitis, Ulcerative ,Female ,business - Abstract
Clinical usefulness of cytomegalovirus (CMV) antigenemia assay and blood CMV polymerase chain reaction (PCR) in patients with ulcerative colitis (UC) needs to be evaluated.Medical records of moderate to severe UC patients between January 2001 and December 2012 were reviewed retrospectively. Diagnostic performances of CMV antigenemia assay and blood PCR to predict CMV colitis, and clinical outcome according to the results were analyzed. CMV colitis was diagnosed by HE staining and/or CMV immunohistochemistry.Of the 229 study subjects, 83 patients (36.2%) had CMV colitis. The sensitivity and specificity of CMV antigenemia assay were 47.0% and 81.7%, and those of blood CMV DNA PCR were 44.3% and 87.9%, respectively. If either CMV antigenemia or PCR was positive in the presence of significant ulcers, the sensitivity and specificity of having CMV colitis were 67.3% and 75.7%, respectively, with the area under the receiver operating characteristic curve value of 0.717. Among patients with significant ulcers, positive CMV antigenemia (33/50 [66.0%] vs. 31/102 [30.4%]; p0.001) and positive blood CMV PCR (25/37 [67.6%] vs. 24/86 [27.9%]; p0.001) showed significantly higher probability of CMV colitis than blood test-negative patients. UC-CMV colitis patients with positive CMV antigenemia showed significantly higher rate of colectomy than those with negative antigenemia (13/39 [33.3%] vs. 5/44 [11.4%]; p=0.015).Although CMV antigenemia and blood CMV PCR showed low sensitivity for diagnosing CMV colitis, the specificity values were high. Among UC-CMV colitis patients, CMV antigenemia showed significant association with subsequent colectomy.
- Published
- 2014
36. Dictyopteris undulata extract induces apoptosis in human colon cancer cells
- Author
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Ji Won Cha, Jian Zheng, Chang Lim Hyun, Jin Won Hyun, Nam Ho Lee, Soo Young Na, Cheng Wen Yao, Kyoung Ah Kang, Ki Cheon Kim, Sun Jin Boo, Areum Kim, and Mei Jing Piao
- Subjects
Programmed cell death ,education.field_of_study ,Population ,Biomedical Engineering ,Bioengineering ,Biology ,Apoptotic body ,Applied Microbiology and Biotechnology ,Molecular biology ,digestive system diseases ,medicine.anatomical_structure ,Apoptosis ,Immunology ,medicine ,DNA fragmentation ,Cytotoxic T cell ,Viability assay ,education ,B cell ,Biotechnology - Abstract
The present study investigated the cytotoxic and apoptotic effects of an ethanol extract derived from the marine brown alga Dictyopteris undulata against human colon adenocarcinoma cells. The Dictyopteris undulata extract (DUE) showed cytotoxic activity against SW480 cells in a dose-dependent manner, with 50% inhibition of cell viability at a concentration of 40 μg/mL. DUE also induced programmed cell death in SW480 cells, as evidenced by apoptotic body formation, DNA fragmentation, an increase in the population of apoptotic sub-G1 phase cells, and mitochondrial membrane depolarization. Moreover, DUE significantly modulated the expression of apoptosisassociated proteins, resulting in a decrease in B cell lymphoma-2 expression and an increase in Bcl-2-associated X protein expression, as well as the activation of caspase-9 and caspase-3. Furthermore, DUE showed apoptotic cell death in two other colon cancer cell lines, SNU407 and HT29. These observations suggest that DUE may prove useful as a therapeutic agent for the attenuation of colon cancer.
- Published
- 2014
37. The ethyl acetate fraction ofSargassum muticumattenuates ultraviolet B radiation-induced apoptotic cell death via regulation of MAPK- and caspase-dependent signaling pathways in human HaCaT keratinocytes
- Author
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Hee Kyoung Kang, Young Sang Koh, Mi Hee Ko, Eun Sook Yoo, Sun Jin Boo, Weon Jong Yoon, Jin Won Hyun, Ji Won Cha, Nam Ho Lee, Jian Zheng, Cheng Wen Yao, Ki Cheon Kim, and Mei Jing Piao
- Subjects
Keratinocytes ,MAPK/ERK pathway ,Cell Survival ,MAP Kinase Signaling System ,Ultraviolet Rays ,Cell ,Pharmaceutical Science ,Apoptosis ,DNA Fragmentation ,Acetates ,Biology ,Cell Line ,Drug Discovery ,medicine ,Humans ,Viability assay ,Phosphorylation ,Fragmentation (cell biology) ,Pharmacology ,Microscopy, Confocal ,integumentary system ,Caspase 3 ,Plant Extracts ,Sargassum ,General Medicine ,Flow Cytometry ,Apoptotic body ,Caspase 9 ,Cell biology ,HaCaT ,medicine.anatomical_structure ,Complementary and alternative medicine ,Molecular Medicine ,DNA fragmentation ,Signal Transduction - Abstract
Our previous work demonstrated that an ethyl acetate extract derived from Sargassum muticum (Yendo) Fenshol (SME) protected human HaCaT keratinocytes against ultraviolet B (UVB)-induced oxidative stress by increasing antioxidant activity in the cells, thereby inhibiting apoptosis.The aim of the current study was to further elucidate the anti-apoptotic mechanism of SME against UVB-induced cell damage.The expression levels of several apoptotic-associated and mitogen-activated kinase (MAPK) signaling proteins were determined by western blot analysis of UVB-irradiated HaCaT cells with or without prior SME treatment. In addition, the loss of mitochondrial membrane potential (Δψm) was detected using flow cytometry or confocal microscopy and the mitochondria membrane-permeate dye, JC-1. Apoptosis was assessed by quantifying DNA fragmentation and apoptotic body formation. Furthermore, cell viability was evaluated using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.SME absorbed electromagnetic radiation in the UVB range (280-320 nm) of the UV/visible light spectrum. SME also increased Bcl-2 and Mcl-1 expression in UVB-irradiated cells and decreased the Bax expression. Moreover, SME inhibited the UVB-induced disruption of mitochondrial membrane potential and prevented UVB-mediated increases in activated caspase-9 and caspase-3 (an apoptotic initiator and executor, respectively) levels. Notably, treatment with a pan-caspase inhibitor enhanced the anti-apoptotic effects of SME in UVB-irradiated cells. Finally, SME reduced the UVB-mediated phosphorylation of p38 MAPK and JNK, and prevented the UVB-mediated dephosphorylation of Erk1/2 and Akt.The present results indicate that SME safeguards HaCaT keratinocytes from UVB-mediated apoptosis by inhibiting a caspase-dependent signaling pathway.
- Published
- 2014
38. Su1753 DOES THE PERSONALITY TRAITS OF ENDOSCOPISTS AFFECT ADENOMA DETECTION RATE DURING COLONOSCOPY? A KASID MULTICENTER STUDY
- Author
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Sun-Jin Boo, Jong Wook Kim, Hyo-Joon Yang, Soo-Young Na, Yunho Jung, Kyeong Ok Kim, Jeong Eun Shin, Seong Ran Jeon, Jun Lee, Jae Hyun Kim, Yoo Jin Lee, Hoon Sup Koo, Su Jung Han, Young-Eun Joo, Hwangbo Young, Jae Kook Yang, Mee Jung Han, Kyu Chan Huh, Hyun Gun Kim, and Jae Myung Cha
- Subjects
medicine.medical_specialty ,Adenoma ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Colonoscopy ,medicine.disease ,Affect (psychology) ,Multicenter study ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,Big Five personality traits ,Detection rate ,business - Published
- 2019
39. Endoscopic Ultrasound-Guided Perirectal Abscess Drainage without Drainage Catheter: A Case Series
- Author
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Heung Up Kim, Byung-Cheol Song, Sun-Jin Boo, Eun Kwang Choi, Soo-Young Na, Seung Uk Jeong, and Ji Hyun Kim
- Subjects
Endoscopic ultrasound ,lcsh:Internal medicine ,medicine.medical_specialty ,Common disease ,Medicine (miscellaneous) ,Case Report ,Endosonography ,03 medical and health sciences ,0302 clinical medicine ,Catheter drainage ,medicine ,Radiology, Nuclear Medicine and imaging ,lcsh:RC799-869 ,Drainage ,lcsh:RC31-1245 ,Abscess ,Perirectal abscess ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,medicine.disease ,Anus ,Alternative treatment ,Surgery ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,lcsh:Diseases of the digestive system. Gastroenterology ,030211 gastroenterology & hepatology ,Radiology ,Complication ,business - Abstract
A perirectal abscess is a relatively common disease entity that occurs as a postsurgical complication or as a result of various medical conditions. Endoscopic ultrasound (EUS)-guided drainage was recently described as a promising alternative treatment. Previous reports have recommended placement of a drainage catheter through the anus for irrigation, which is inconvenient to the patient and carries a risk of accidental dislodgement. We report four cases of perirectal abscess that were successfully treated with only one or two 7 F double pigtail plastic stent placements and without a drainage catheter for irrigation.
- Published
- 2016
40. Risk of advanced colorectal neoplasm in patients with more than 10 adenomas on index colonoscopy: A Korean Association for the Study of Intestinal Diseases (KASID) study
- Author
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Soo-Kyung, Park, Sung Wook, Hwang, Kyeong Ok, Kim, Jae Myung, Cha, Sun-Jin, Boo, Jeong Eun, Shin, Young-Eun, Joo, Yunho, Jung, Jun, Lee, Hyo-Joon, Yang, and Dong Il, Park
- Subjects
Adenoma ,Male ,Risk ,Time Factors ,Age Factors ,Colonoscopy ,Middle Aged ,Cohort Studies ,Humans ,Multicenter Studies as Topic ,Female ,Colorectal Neoplasms ,Aged ,Follow-Up Studies ,Neoplasm Staging ,Retrospective Studies - Abstract
The number of patients with10 adenomas is relatively small, and few studies have investigated the risk of colorectal neoplasm (CRN) in these patients. Thus, we aimed to investigate the risk of developing CRN in patients with10 adenomas and to compare their risk with that of patients with 3-10 adenomas.A retrospective multicenter cohort study that included 214 patients with10 adenomas on index colonoscopy performed between January 2009 and December 2011, and underwent follow-up colonoscopy until December 2015 was conducted. The risk of developing advanced CRN (cancer or advanced adenoma with a diameter of ≥10 mm or with a villous component, or high-grade dysplasia) was investigated and compared with that in patients with 3-10 adenomas (n = 975).Among the 214 patients with10 adenomas, the mean age was 62.9 years and the mean number of adenomas on index colonoscopy was 14.2. Overall, 57 patients (26.6%) developed an advanced CRN after a mean of 4.3 years from baseline colonoscopy. The respective 3- and 5-year cumulative risks of advanced CRN were 6.8% (95% confidence interval [CI] 2.9-10.7) and 28.7% (95% CI 20.8-36.5), higher than those in the group with 3-10 adenomas (n = 975, P = 0.001). Having10 adenomas on index colonoscopy was an independent risk factor for developing advanced CRN (odds ratio 2.25, 95% CI 1.49-3.38).The risk of developing advanced CRN in patients with10 adenomas was high and statistically higher than that in patients with 3-10 adenomas. Further prospective studies are needed to investigate whether a more intensive surveillance is needed in this group.
- Published
- 2016
41. Reduced Autophagy in 5-Fluorouracil Resistant Colon Cancer Cells
- Author
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Seung Uk Jeong, Kyoung Ah Kang, Jin Won Hyun, Kristina Shilnikova, Pattage Madushan Dilhara Jayatissa Fernando, Jeong Eon Park, Soo-Young Na, Cheng Wen Yao, Mei Jing Piao, Yea Seong Ryu, Sun-Jin Boo, and Min Chang Oh
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,Colorectal cancer ,5-Fluorouracil ,ATG5 ,Biochemistry ,Flow cytometry ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,Confocal microscopy ,law ,Internal medicine ,Drug Discovery ,medicine ,Autophagy ,Pharmacology ,chemistry.chemical_classification ,Reactive oxygen species ,medicine.diagnostic_test ,Acridine orange ,medicine.disease ,Molecular biology ,Staining ,Colon cancer ,030104 developmental biology ,chemistry ,Molecular Medicine ,Original Article ,SNUC5/5-FUR - Abstract
We investigated the role of autophagy in SNUC5/5-FUR, 5-fluorouracil (5-FU) resistant SNUC5 colon cancer cells. SNUC5/5- FUR cells exhibited low level of autophagy, as determined by light microscopy, confocal microscopy, and flow cytometry following acridine orange staining, and the decreased level of GFP-LC3 puncta. In addition, expression of critical autophagic proteins such as Atg5, Beclin-1 and LC3-II and autophagic flux was diminished in SNUC5/5-FUR cells. Whereas production of reactive oxygen species (ROS) was significantly elevated in SNUC5/5-FUR cells, treatment with the ROS inhibitor N-acetyl cysteine further reduced the level of autophagy. Taken together, these results indicate that decreased autophagy is linked to 5-FU resistance in SNUC5 colon cancer cells.
- Published
- 2016
42. Induction of Endoplasmic Reticulum Stress via Reactive Oxygen Species Mediated by Luteolin in Melanoma Cells
- Author
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Joon Ki, Kim, Kyoung Ah, Kang, Yea Seong, Ryu, Mei Jing, Piao, Xia, Han, Min Chang, Oh, Sun Jin, Boo, Seung Uk, Jeong, Yong Joo, Jeong, Sungwook, Chae, Soo-Young, Na, and Jin Won, Hyun
- Subjects
Staining and Labeling ,Apoptosis ,Endoplasmic Reticulum Stress ,Transfection ,Activating Transcription Factor 6 ,Mitochondria ,Neoplasm Proteins ,Gene Expression Regulation, Neoplastic ,Cell Line, Tumor ,Humans ,Calcium ,RNA, Small Interfering ,Luteolin ,Reactive Oxygen Species ,Melanoma ,Transcription Factor CHOP ,Tumor Stem Cell Assay - Abstract
This study aimed to investigate whether luteolin, a flavonoid, induces apoptosis in human melanoma cells via endoplasmic reticulum (ER) stress.To investigate the effects of luteolin in human melanoma cells, the anti-proliferation, apoptosis, ER stress induction and reactive oxygen species (ROS) generation were evaluated using MTT, Hoechst 33342, ER-tracker Blue White DPX and DCF-DA staining assays, respectively.Luteolin inhibited cell proliferation and increased apoptotic body formation. Luteolin induced ER stress, as shown by ER staining and mitochondrial Ca(2+) overloading. Luteolin increased expression of the ER stress-related proteins; protein kinase RNA-like ER kinase, phospho eukaryotic translation initiation factor 2α, activating transcription factor (ATF) 6, CCAAT/enhancer-binding protein-homologous protein (CHOP), and cleaved caspase 12. Furthermore, luteolin increased the level of intracellular ROS, leading to ROS-mediated apoptosis and ER stress. However, N-acetyl cysteine, a ROS scavenger, decreased ROS levels, apoptosis, and ER stress induced by luteolin treatment. In addition, knockdown of CHOP and ATF6 by small-interfering RNA inhibited luteolin-induced cell death.Luteolin induces apoptosis by ER stress via increasing ROS levels.
- Published
- 2016
43. Su1653 Factors Predictive of Complete Excision of Large Colorectal Neoplasia by Hybrid Endoscopic Submucosal Dissection; a Kasid Multicenter Study
- Author
-
Hyun Gun Kim, Hoon Sup Koo, Jeong-Sik Byeon, Jun Lee, Jong Wook Kim, Sun-Jin Boo, Young Hwangbo, and Yunho Jung
- Subjects
medicine.medical_specialty ,Multicenter study ,business.industry ,Gastroenterology ,medicine ,Radiology, Nuclear Medicine and imaging ,Endoscopic submucosal dissection ,business ,Surgery - Published
- 2017
44. 772 THE RELATIONSHIP BETWEEN THE ENDOSCOPIC WITHDRAWAL TIME AND ADENOMA/POLYP DETECTION RATE IN INDIVIDUAL COLONIC SEGMENTS. A KASID MULTICENTER STUDY
- Author
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Yunho Jung, Jeong Eun Shin, Young-Eun Joo, Hyun Gun Kim, Jong Wook Kim, Hyo-Joon Yang, Jae Myung Cha, Jun Lee, Kyeong Ok Kim, Sun-Jin Boo, Chang Mo Moon, Hoon Sup Koo, and Young Hwangbo
- Subjects
Gastroenterology ,Radiology, Nuclear Medicine and imaging - Published
- 2018
45. Regression of esophageal varices during entecavir treatment in patients with hepatitis-B-virus-related liver cirrhosis
- Author
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Byoung Wook Lee, Hye Young Jwa, Bong Soo Kim, Yoo Kyung Cho, Byung-Cheol Song, Seung Uk Jeong, Heung Up Kim, Eun Kwang Choi, Hyun Joo Song, Soo Young Na, and Sun Jin Boo
- Subjects
Liver Cirrhosis ,Male ,medicine.medical_specialty ,Hepatitis B virus ,Cirrhosis ,Guanine ,Case Report ,Esophageal varices ,medicine.disease_cause ,Esophageal and Gastric Varices ,Gastroenterology ,Antiviral Agents ,Polymerase Chain Reaction ,03 medical and health sciences ,0302 clinical medicine ,Hepatitis B, Chronic ,Internal medicine ,Complete regression ,Abdomen ,medicine ,Humans ,In patient ,lcsh:RC799-869 ,Molecular Biology ,Ultrasonography ,Hepatology ,business.industry ,fungi ,Entecavir ,Middle Aged ,Hbv replication ,medicine.disease ,030220 oncology & carcinogenesis ,DNA, Viral ,030211 gastroenterology & hepatology ,lcsh:Diseases of the digestive system. Gastroenterology ,business ,medicine.drug - Abstract
Recent studies suggest that liver cirrhosis is reversible after administering oral nucleos(t)ide analogue therapy to patients with hepatitis B virus (HBV) infection. However, few studies have addressed whether esophageal varices can regress after such therapy. We report a case of complete regression of esophageal varices during entecavir therapy in patients with HBV-related liver cirrhosis, suggesting that complications of liver cirrhosis such as esophageal varices can regress after the long-term suppression of HBV replication.
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- 2015
46. [Additional polyp detection rate using colonoscopic retroflexion in right colon]
- Author
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Heung Up Kim, Hyun Joo Song, Soo Young Na, and Sun Jin Boo
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Adenoma ,Adult ,Male ,medicine.medical_specialty ,Abdominal pain ,Perforation (oil well) ,Colonoscopy ,Colonic Polyps ,Gastroenterology ,Internal medicine ,Medicine ,Ascending colon ,Humans ,Aged ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Medical record ,General Medicine ,Middle Aged ,medicine.disease ,Diverticulosis ,Colon, Descending ,Colonic Neoplasms ,Female ,Radiology ,medicine.symptom ,Detection rate ,business - Abstract
BACKGROUND/AIMS There have been several studies showing that retroflexion (RF) in the right colon (RC) could reduce the polyp miss rate of proximal colon during colonoscopy. This study was conducted to evaluate the additional benefit of RF technique in the RC. METHODS Patients who underwent colonoscopy from May 2008 to April 2011 were enrolled in the study. Data were obtained by retrospectively reviewing the medical records. RF was attempted in every patients undergoing colonoscopy since May 2008 except in cases of small RC vault, co-morbidity, severe diverticulosis, failed RF despite two trials, complaints of severe abdominal pain, or time burden. At first, RC was examined under direct vision. It was then examined by RF to detect missed polyps during the initial observation. Finally, the RC was re-examined with direct view. RESULTS The cumulative RF success rate in the RC was 78.84% (1,805 of 2,319). The RF success rate increased with the number of cases (50% at 160 cases, 70% at 400 cases, and reached near 90% over 1,000 cases). Few polyps (4.88%) were detected only with RF and the additional adenoma detection rate was 3.32%. The additional polyp/adenoma detection rates were higher in the old age group (p
- Published
- 2015
47. Primary intestinal lymphangiectasia with generalized warts
- Author
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Soo-Young Na, Heung Up Kim, Sun-Jin Boo, Soon Jae Lee, Chang Lim Hyun, and Hyun Joo Song
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pathology ,Biopsy ,Case Report ,Opportunistic Infections ,Gastroenterology ,Capsule Endoscopy ,law.invention ,Hypogammaglobulinemia ,Immunocompromised Host ,Capsule endoscopy ,law ,Internal medicine ,medicine ,Humans ,Enteropathy ,Lymphedema ,Diet, Fat-Restricted ,Immunodeficiency ,Triglycerides ,medicine.diagnostic_test ,business.industry ,Protein losing enteropathy ,Papillomavirus Infections ,General Medicine ,Colonoscopy ,medicine.disease ,Immunohistochemistry ,Treatment Outcome ,Chronic Disease ,Papilloma ,Dietary Proteins ,Lymphocytopenia ,Warts ,business ,Tomography, X-Ray Computed ,Lymphangiectasis, Intestinal - Abstract
Primary intestinal lymphangiectasia (PIL) is a rare protein-losing enteropathy with lymphatic leakage into the small intestine. Dilated lymphatics in the small intestinal wall and mesentery are observed in this disease. Laboratory tests of PIL patients revealed hypoalbuminemia, lymphocytopenia, hypogammaglobulinemia and increased stool α-1 antitrypsin clearance. Cell-mediated immunodeficiency is also present in PIL patients because of loss of lymphocytes. As a result, the patients are vulnerable to chronic viral infection and lymphoma. However, cases of PIL with chronic viral infection, such as human papilloma virus-induced warts, are rarely reported. We report a rare case of PIL with generalized warts in a 36-year-old male patient. PIL was diagnosed by capsule endoscopy and colonoscopic biopsy with histological tissue confirmation. Generalized warts were observed on the head, chest, abdomen, back, anus, and upper and lower extremities, including the hands and feet of the patient.
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- 2015
48. Ophthalmologic manifestations in patients with inflammatory bowel disease
- Author
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Heung Up Kim, Jin Ho Jeong, Sun-Jin Boo, Hye Jin Lee, Hyun Joo Song, and Soo-Young Na
- Subjects
medicine.medical_specialty ,lcsh:Medicine ,Dry Eye Syndromes ,Disease ,Inflammatory bowel disease ,Dry eye syndromes ,Colitis, ulcerative ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Optic neuritis ,lcsh:RC799-869 ,Colitis ,business.industry ,lcsh:R ,Gastroenterology ,Crohn disease ,Episcleritis ,medicine.disease ,Ulcerative colitis ,Dermatology ,digestive system diseases ,Ophthalmology ,030221 ophthalmology & optometry ,lcsh:Diseases of the digestive system. Gastroenterology ,Original Article ,030211 gastroenterology & hepatology ,business ,Complication - Abstract
Background/aims Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), has been reported to have various ophthalmologic manifestations. The aim of this study was to evaluate the prevalence of ophthalmologic manifestations associated with IBD in Korea. Methods Sixty-one patients were examined between May 2013 and October 2014. We performed complete ophthalmologic examinations. Results Findings included 36 patients with CD and 25 with UC. The mean age of the patients was 34±16 years and disease duration was 45.3±23.9 months. Ophthalmologic manifestations were positive in 44 cases. Primary complication was diagnosed in 5 cases, as follows; iritis in 2 cases, episcleritis in one case, iritis with optic neuritis in 1 case, and serous retinal detachment in 1 case, without secondary complications. The most common coincidental complication was dry eye syndrome (DES), in 35 patients (57.4%). The prevalence of DES in the control group was 21.3%. The proportion of DES in patients with IBD was significantly higher than in the control group (P=0.002). Conclusions Ophthalmologic manifestations were high (72.1%) in IBD patients. Clinically significant primary ocular inflammation occurred in 8.2% of patients. The most common complication was DES. There was a higher rate of DES in patients with IBD compared to the control group. Evaluation of the eye should be a routine component in patients with IBD.
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- 2017
49. Usefulness of C-reactive protein as a disease activity marker in Crohn's disease according to the location of disease
- Author
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Suk-Kyun Yang, Byong Duk Ye, Ho-Su Lee, Soo Young Na, Seung-Jae Myung, Jae-Ho Park, Jin Ho Kim, Kyung-Jo Kim, Kee Wook Jung, Dong-Hoon Yang, Jeong-Sik Byeon, Sun-Jin Boo, and Sang Hyoung Park
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pathology ,Adolescent ,Colon ,Serum albumin ,Inflammation ,Ileum ,Disease ,Blood Sedimentation ,Gastroenterology ,Severity of Illness Index ,Serology ,C-reactive protein ,Young Adult ,Internal medicine ,Severity of illness ,Medicine ,Humans ,Child ,Serum Albumin ,Aged ,Crohn's disease ,Hepatology ,biology ,business.industry ,Crohn disease ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,biology.protein ,Female ,Original Article ,medicine.symptom ,business ,Biomarkers - Abstract
Background/Aims: C-reactive protein (CRP) is a serologic activity marker in Crohn’s disease (CD), but it may be less useful in evaluating CD activity in ileal CD patients. We aimed to investigate the usefulness of CRP as a disease activity marker in CD according to disease location. Methods: Korean CD patients in a single hospital were evaluated. Factors associated with elevated CRP concentration at the time of diagnosis of CD and the association between the physician’s prediction regarding upcoming surgery and the sites of the lesions directly related to surgery were analyzed. Results: Of 435 CD patients, 25.7%, 6.9%, and 67.4% had ileal, colonic, and ileocolonic CD, respectively. Multivariate analysis revealed that an elevated erythrocyte sedimentation rate, reduced serum albumin, CD activity index (CDAI) >220, and ileocolonic/colonic location were associated with an elevated CRP level and that the CRP level was significantly correlated with the CDAI in all CD patients (γ=0.466, p
- Published
- 2014
50. Cytoprotective effects of 6'-O-galloylpaeoniflorin against ultraviolet B radiation-induced cell damage in human keratinocytes
- Author
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Cheng Wen Yao, Sun Jin Boo, Suk Ju Cho, Ji Won Cha, Jian Zheng, Jin Won Hyun, Chang Lim Hyun, Mei Jing Piao, Ki Cheon Kim, and Soo Young Na
- Subjects
Keratinocytes ,Programmed cell death ,DNA damage ,Ultraviolet Rays ,Blotting, Western ,Skin Diseases ,Lipid peroxidation ,chemistry.chemical_compound ,Glucosides ,medicine ,In Situ Nick-End Labeling ,Humans ,Cell damage ,chemistry.chemical_classification ,Reactive oxygen species ,Apoptosis Inducing Factor ,Cell Biology ,General Medicine ,medicine.disease ,Bridged Bicyclo Compounds, Heterocyclic ,Cell biology ,Comet assay ,HaCaT ,chemistry ,Apoptosis ,Cytoprotection ,Monoterpenes ,Comet Assay ,Lipid Peroxidation ,Reactive Oxygen Species ,Developmental Biology ,DNA Damage - Abstract
The cytoprotective effects of 6'-O-galloylpaeoniflorin against injury and death of human HaCaT keratinocytes resulting from ultraviolet B radiation were investigated. 6'-O-galloylpaeoniflorin exhibited the capacity to scavenge intracellular reactive oxygen species (ROS) generated by ultraviolet B radiation. 6'-O-galloylpaeoniflorin also attenuated ultraviolet B-induced oxidative macromolecular damage to DNA, lipids, and proteins, decreasing the number of DNA strand breaks, the level of 8-isoprostane (a biomarker of lipid peroxidation), and the level of protein carbonylation. Moreover, 6'-O-galloylpaeoniflorin rescued HaCaT cells from ultraviolet induced cell death, by downregulating the mitochondrial apoptotic pathway. Taken together, these results indicate that 6'-O-galloylpaeoniflorin has the potential to be developed as a medical agent against ROS-mediated skin diseases.
- Published
- 2014
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