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Usefulness of C-reactive protein as a disease activity marker in Crohn's disease according to the location of disease
- Source :
- Gut and Liver
- Publication Year :
- 2014
-
Abstract
- Background/Aims: C-reactive protein (CRP) is a serologic activity marker in Crohn’s disease (CD), but it may be less useful in evaluating CD activity in ileal CD patients. We aimed to investigate the usefulness of CRP as a disease activity marker in CD according to disease location. Methods: Korean CD patients in a single hospital were evaluated. Factors associated with elevated CRP concentration at the time of diagnosis of CD and the association between the physician’s prediction regarding upcoming surgery and the sites of the lesions directly related to surgery were analyzed. Results: Of 435 CD patients, 25.7%, 6.9%, and 67.4% had ileal, colonic, and ileocolonic CD, respectively. Multivariate analysis revealed that an elevated erythrocyte sedimentation rate, reduced serum albumin, CD activity index (CDAI) >220, and ileocolonic/colonic location were associated with an elevated CRP level and that the CRP level was significantly correlated with the CDAI in all CD patients (γ=0.466, p
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Adolescent
Colon
Serum albumin
Inflammation
Ileum
Disease
Blood Sedimentation
Gastroenterology
Severity of Illness Index
Serology
C-reactive protein
Young Adult
Internal medicine
Severity of illness
Medicine
Humans
Child
Serum Albumin
Aged
Crohn's disease
Hepatology
biology
business.industry
Crohn disease
Middle Aged
medicine.disease
medicine.anatomical_structure
biology.protein
Female
Original Article
medicine.symptom
business
Biomarkers
Subjects
Details
- ISSN :
- 20051212
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Gut and liver
- Accession number :
- edsair.doi.dedup.....b79c2ae0433a210afe07c03c3459797e