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26. Abstracts of selected papers presented at the 78th general meeting of the Japanese Society of Gastroenterology

Author

Kusano, Motoyasu, Sekiguchi, Toshikazu, Hanyu, Nobuyoshi, Aoki, Teruaki, Matsushima, Yasuhiro, Okamoto, Eizo, Takeda, Yasuo, Takeda, Ryoyu, Miyachi, Masahiko, Nimura, Yuji, Arai, Taidoh, Masuda, Jun, Tanaka, Masao, Ogawa, Yoshiaki, Ura, Kazuhide, Matsumoto, Teiji, Taniyama, K., Kurosawa, Susumu, Owyang, Chung, Baba, Hiroshi, Fujimura, Masaki, Hamada, Eiji, Shimada, Tadahito, Kabemura, Teppei, Chijiiwa, Yoshiharu, Sato, T., Koito, K., Matsuda, Hiroko, Kawasaki, Tsunehisa, Obara, Katsutoshi, Kasukawa, Reiji, Miyoshi, Hirofumi, Matsumoto, Akio, Yamamoto, Manabu, Ohmasa, Ryouji, Kokubu, Shigehiro, Shibata, Hisao, Tajiri, Takashi, Onda, Masahiko, Hashizume, Makoto, Sugimachi, Keizo, Kobayashi, Kenji, Shiozaki, Hitoshi, Fujisaki, Junko, Shimoda, Tadakazu, Hase, Satoshi, Tsukamoto, Yoshihisa, Atsumi, M., Konishi, H., Nakajo, Shinobu, Fujiyama, Yoshihide, Taruishi, Masaki, Ayabe, Tokiyoshi, Morise, Kimitomo, Yamaguchi, Takeo, Makiyama, Kazuya, Itsuno, Minoru, Matsui, T., Okabe, N., Okabe, Nobuo, Matsui, Toshiyuki, Sakatani, Arata, Koizumi, Koichi, Imai, Yutaka, Sugino, Yoshinori, Masaki, Tadahiko, Sawada, Toshio, Nishigami, Takashi, Satomi, Masamichi, Hatada, Yasumasa, Saito, Hiroshi, Kobayshi, Kiyonori, Katsumata, Tomoe, Sugimoto, Kenji, Itabashi, Tsukasa, Kitagawa, Motoji, Hayakawa, Tetsuo, Okazaki, Kazuichi, Yamamoto, Yasuro, Funakoshi, Akihiro, Miyasaka, Kyoko, Soejima, Kazuhiko, Kanda, Mikio, Sugiyama, Masanori, Kuroda, Akira, Inoue, Hisayuki, Bamba, Tadao, Hamanaka, Y., Suzuki, T., Suzuki, Mamoru, Hanyu, Fujio, Tamura, Katsuhiro, Nakase, Akira, Noguchi, M., Hiwatashi, N., Murata, Yuhji, Suzuki, Kazuo, Ohtani, Haruo, Watanabe, Yoshihisa, Zeniya, Mikio, Aizawa, Yoshio, Masumoto, T., Onji, M., Hamasaki, Keisuke, Nakata, Keisuke, Fukui, Hiroshi, Tsujii, Tadasu, Yamashiki, Masayoshi, Nishimura, Akira, Tsutsui, Hiroko, Mizoguchi, Yasuhiro, Kimura, Fumio, Miyazaki, Masaru, Kiyota, Keisuke, Inokuchi, Hideto, Yamamoto, Yoshihiro, Oka, Hiroshi, Horikoshi, Tsutomu, Sekiguchi, Toshikazu, Takayasu, H., Shirai, T., Hongo, Michio, Okuno, Yo, Okano, H., Aoyama, N., Ohsuki, Masao, Maeda, Kenji, Haruma, Ken, Sumii, Koji, Nakai, Yoshihide, Fukunaga, Mikihiko, Kaneko, Hiroshi, Morise, Kimitomo, Okumura, Toshikatsu, Uehara, Akira, Fukuda, Yoshihiro, Satomi, Masamichi, Joh, Takashi, Itoh, Makoto, Kitagawa, Yuko, Kitajima, Masaki, Iwao, Tadashi, Toyonaga, Atsushi, Nakamura, Masahiko, Oda, Masaya, Kawamura, Yukimitsu, Dohden, Kenji, Kamiyama, Yasuhiko, Matsuno, Seiki, Hirano, Morihisa, Otsuka, Sachio, Ito, Masahiro, Sekine, Ichiro, Ogihara, Tatsuo, Sato, Nobuhiro, Uehara, Akira, Namiki, Masayoshi, Sugiura, Nobuyuki, Ebara, Masaaki, Matsuo, Naoki, Uchida, Hideo, Okada, Shuichi, Okazaki, Nobuo, Tsujii, Hirohiko, Ohsuga, Toshiaki, Abe, M., Nagata, Y., Yamasaki, Susumu, Kosuge, Tomoo, Kitamoto, Mikiya, Nakanishi, Toshio, Ichikawa, Yuzo, Mizoguchi, Yasuhiro, Ohtake, Yoshio, Hirasawa, Hiroyuki, Sugihara, Junichi, Muto, Yasutoshi, Yasunaga, Mitsuru, Okita, Kiwamu, Ukida, Minoru, Tsuji, Takao, Isai, Hideya, Uchino, Junichi, Suzuki, Katsuhiko, Komatsu, Kanji, Ohtomo, Yumiko, Idezuki, Yasuo, Sakuramachi, Shunji, Kimura, Taizo, Kitano, Seigo, Sugimachi, Keizo, Moriyama, Masaaki, Yazaki, Yasuyuki, and Saito, Takashige

Published
1993
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28. Evidence that endogenous GRP in rat stomach mediates omeprazole-induced hypergastrinemia

Author

Takehara, Yoshihiko, Sumii, Koji, Tari, Akira, Yoshihara, Masaharu, Haruma, Ken, Kajiyama, Goro, Wu, S. Vincent, and Walsh, John H.

Subjects
Gastrin -- Physiological aspects, Rats -- Physiological aspects, Stomach -- Physiological aspects, Omeprazole -- Physiological aspects, Biological sciences
Abstract

An investigation of gastrin release in a murine model of hypergastrinemia induced by omeprazole, a drug for treating ulcers, has provided evidence to support that endogenous gastrin-releasing peptide (GRP) mediates gastrin secretion. It was shown that during hypergastrinemia, the inhibition of gastrin release activates a signal for the release of GRP, which, in turn, stimulates gastrin secretion.

Published
1996

32. Effect of histamine on rat gastric H+-K+-ATPase alpha-subunit expression

Author

Tari, Akira, Yamamoto, Gohso, Yonei, Yoshikazu, Sumii, Masaharu, Sumii, Koji, Haruma, Ken, Kajiyama, Goro, Wu, Vincent, Sachs, George, and Walsh, John H.

Subjects
Stomach -- Secretions, Histamine receptors -- Physiological aspects, Biological sciences
Abstract

Studies on rat gastric H+-K+-ATPase alpha subunit reveal that H2 receptor activation leads to histamine stimulation of H+-K+-ATPase alpha subunit activity. Famotidine, which enhances gastric pH and serum gastrin, reduces the H2 receptor action. It also reduces the level of H+-K+-ATPase mRNA.

Published
1994

42. Proliferating cell nuclear antigen expression at the invasive tumor margin predicts malignant potential of colorectal carcinomas

Author

Teixeria, Claudio R., Tanaka, Shinji, Haruma, Ken, Yoshihara, Masaharu, Sumii, Koji, and Kajiyama, Goro

Subjects
Colorectal cancer -- Identification and classification, Cancer invasiveness -- Physiological aspects, Tumor antigens, Health
Abstract

Background. Proliferative activity may be a useful measure of malignant potential for a variety of tumors. Colorectal carcinomas contain multiple cell populations with different biologic properties. The invasive tumor margin is thought to represent the area with the highest metastatic potential. Methods. Cell proliferation at the invasive tumor margin of 49 specimens of advanced colorectal carcinoma was assessed by immunohistochemical staining of proliferating cell nuclear antigen (PCNA) and compared with clinicopathologic findings. Results. Colorectal carcinomas showed a wide range of PCNA labeling indexes (LI), reflecting variation in proliferative activity. The PCNA LI of tumors showing venous invasion (mean, 51.7% [+ or -] 16.2%) was significantly higher than that of tumors without venous invasion (mean, 36.7% [+ or -] 18.2%; P < 0.01). A strong association was observed between the PCNA Ll and the metastatic potential of colorectal carcinoma; the PCNA LI of tumors showing lymph node metastasis (mean, 50.5% [+ or -] 17%) was significantly higher than that of tumors without nodal involvement (mean, 39.8% [+ or -] 18.5%; P < 0.05). In addition, the PCNA LI of tumors metastatic to liver (mean, 55.2% [+ or -] 15.7%) was significantly higher than that of tumors without liver metastasis (mean, 41.0% [+ or -] 17.6%; P < 0.01). Correlation with histologic features at the invasive tumor margin showed that a higher PCNA LI was associated with less differentiated tumors (P < 0.05). Conclusion. Evaluation of the PCNA Ll at the invasive tumor margin may help identify colorectal carcinomas that have a higher malignant potential. Cancer 1994;73:575-9.

Published
1994

43. Flow cytometric DNA analysis of gastric smooth muscle tumors

Author

Shimamoto, Takehiro, Haruma, Ken, Sumii, Koji, Kajiyama, Goro, and Tahara, Eiichi

Subjects
Leiomyoma -- Prognosis, Stomach cancer -- Prognosis, Leiomyosarcoma -- Genetic aspects, Flow cytometry -- Diagnostic use, Health
Published
1992

45. The Usefulness of Gastric Mass Screening Using Serum Pepsinogen Levels Compared with Photofluorography

Author

Yoshihara, Masaharu, Sumii, Koji, Haruta, Ken, Kiyohira, Kuninushi, Hattori, Nobuaki, Tanaka, Shinji, Kajiyama, Goro, and Shigenobu, Takuso

Subjects
Gastric mass screening, Photofluorography, Gastric cancer, digestive system, Serum pepsinogen, digestive system diseases
Abstract

Chronic atrophic gastritis, which is thought to be a high risk for gastric cancer, can be diagnosed by serum pepsinogen levels. We compared the usefulness of the measurement of pepsinogen levels and indirect photofluorography as indicators of gastric cancer in a mass screening involving 5,620 Japanese subjects (mean age: 60.1 years old; male : female = 2,268 : 3,352) in 1991 and 1992. Subjects with a serum pepsinogen I level below 30 μg/liter or a pepsinogen I/II ratio below 2.0 were considered to be at high risk of gastric cancer. The incidence of gastric cancer and the ratio of early cancers detected by pepsinogen levels (0.12%, 4/7) were similar to those detected by photofluorography (0.11 %, 4/6). Our results showed that mass screening using pepsinogen levels was as useful as indirect photofluorography for the detection of gastric cancer in Japan. In addition, our results showed that the sensitivity of gastric mass screening was increased when the measurement of serum pepsinogen levels was combined with photofluorography.

Published
1997

47. Proceedings of the 26th annual meeting Chiba, Japan, October 18–20, 1984

Author

Iwatsuki, Shunzaburo, Hermans, Paul E., Beasley, R. Palmer, Summers, Jesse, Tandon, B. N., Kobayashi, Kenichi, Kinami, Yoshio, Kojiro, Masamichi, Nakashima, Toshiro, Toyosaka, Akihiro, Okamoto, Eizo, Higashi, Shunsaku, Mizumoto, Ryuji, Isobe, Yoshinori, Saitoh, Akiko, Ohue, Shoichi, Ohishi, Hajime, Ebara, Masaaki, Ohto, Masao, Aoyagi, Yutaka, Ichida, Fumihiro, Ido, Kenichi, Kimura, Ken, Tsuchiya, Yukihiro, Sumida, Masatosi, Ichikawa, Kazuo, Nakazawa, Saburo, Mizunuma, Kimiyoshi, Tada, Shimpei, Boto, Nobuo, Miyaji, Makoto, Asano, Eiichi, Nagakawa, Takukazu, Iseki, Joji, Beppu, Tomoe, Sato, Hiromichi, Ito, Jishu, Ogura, Yoshifumi, Mizumoto, Ryuji, Kawaguchi, Hidehiro, Muto, Terukazu, Tsuzuki, Toshiharu, Ogata, Yoshiro, Ono, Mikiko, Sohma, Satoru, Hara, Yasuhiro, Kiyonari, Hideyasu, Hayakawa, Tetsuo, Katada, Naoyuki, Miyashita, Tadashi, Suzuki, Takashi, Ogata, Yoshiro, Hishinuma, Shoichi, Karasawa, Eii, Saisho, Hiromitsu, Suyama, Masafumi, Ariyama, Jo, Fujimoto, Sotaro, Nakajima, Masatsugu, Miyamoto, Toshimitsu, Tsuchiya, Ryoichi, Miyashita, Eishi, Matsuno, Seiki, Wada, Yoshiyuki, Kuroda, Akira, Higashino, Yoshinobu, Nagakawa, Takukazu, Tanaka, Akira, Sakaue, Hiroshi, Yamanaka, Naoki, Okamoto, Eizo, Ozawa, Kazue, Arii, Shigeki, Sakamoto, Akio, Usui, Sadahito, Kawarada, Yoshifumi, Mizumoto, Ryuji, Iida, Shuhei, Tsuzuki, Toshiharu, Okamura, J., Sakurai, M., Shibata, Hisao, Nii, Shigenori, Suenaga, Masahiro, Horisawa, Masumasa, Kondo, Tatsuhei, Kariya, Atsushi, Mayama, Soko, Muto, T., Agawa, S., Kitajima, Y., Morioka, Y., Aisawa, Tadashi, Sano, Masaaki, Hiwatashi, Nobuo, Kitano, A., Kobayashi, K., Fukushima, Tsuneo, Aiso, Sadakazu, Asakura, Hitoshi, Nakano, Hiroshige, Nanba, Koji, Miyake, Hirofumi, Harada, Hideo, Takagi, Kunio, Igarashi, Tsutomu, Kurihara, Youichi, Sumii, Koji, Uemura, Naomi, Takahashi, Hitoshi, Nishigori, Rumiko, Shibata, Hiromi, Muto, Hiroshi, Yanaka, Akinori, Nakahara, Akira, Koyama, Shohei, Fukutomi, Hisayuki, Oosuga, Toshiaki, Harasawa, S., Miura, T., Saigenji, Katsunori, Miwa, Takeshi, Yamagata, Susumu, Fukutomi, Hisayuki, Katsumi, Kohei, Ito, Makoto, Tatsuta, Masaharu, Iishi, Hiroyasu, Okuda, Shigeru, Murai, M., Fukui, K., Sakai, Hideaki, Yoshida, Yukio, Suyama, Kyoichiro, Tsuchiya, Masaharu, Nakamura, Takashi, Ko, Sen, Sato, Masanobu, Kano, Atsushi, Yukawa, Ken-ichi, Yabana, T., Yachi, A., Noda, Hideki, Tobe, Takayoshi, Takahashi, Toku, Yamamura, Takehira, Misawa, Tadashi, Ibayashi, Hiroshi, Kishimoto, S., Shimizu, S., Nishi, Syogoro, Komuro, Terumasa, Uehara, Yasuo, Kobayashi, S., Suzuki, M., Uchida, T., and Yanaihara, N.

Published
1985
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48. Proceedings of the 68th Annual Meeting from March 28th–30th, 1982—Hiroshima, Japan

Author

Miwa, Takeshi, Okabe, S., Takeuchi, K., Yano, Shingo, Yabana, Tsuyoshi, Yoshimura, Yutaka, Fujii, Ken, Sato, Yuichi, Narasaki, Yoshikazu, Kondo, Tetsuo, Akahonai, Yoshikazu, Yachi, Akira, Ogawa, Katsuhiro, Takeuchi, Koji, Nobuhara, Youichi, Yamakuni, Hisashi, Okabe, Susumu, Ohe, Keiji, Nakamura, Michio, Matsumoto, Haruki, Fujiwara, Takashi, Yokoya, Hitoshi, Onda, Masaki, Inoue, Masaki, Miyoshi, Akima, Nakano, Shigeuki, Gonoi, Tetsuro, Moriga, Motoyuki, Ishimori, Akira, Kitajima, M., Kumakura, Kenji, Yao, Tsuneyoshi, Okada, Mitsuo, Rl, Seirai, Shimizu, Naokata, Ogawa, Nobuya, Saigenji, K., Okabe, H., Nakazawa, Saburo, Fukuchi, Sohtaro, Misaki, Fumio, Sumii, Koji, Hayakawa, Akira, Ogoshi, Kazuei, Isobe, Yoshinari, Takahashi, Isao, Miyoshi, Akima, Nakane, Paul K., Brown, William R., Tsuji, Moriyasu, Tanaka, Ko, Miyachi, Yukitaka, Miyoshi, Akima, Yachi, Akira, Akahonai, Yoshikazu, Kanoh, Tadashi, Uchino, Haruto, Fujiyama, Yoshihide, Asakura, Hitoshi, Kuroe, Kiyoo, Murata, Yuji, Kobayashi, Kenzo, Furukawa, Hiroo, Shiwaku, Yoshiyuki, Morita, Norikazu, Inoue, Mikio, Uchida, Yoshihito, Yagita, Akikuni, Kodama, Hiroshi, Tsuchitani, Toshiharu, Nioh, Yoshinori, Yamazaki, Nobuyasu, Kan, Norimichi, Ohgaki, Kazuhisa, Tobe, Takayoshi, Takino, Tatsuro, Ohta, Yasuyuki, Kumada, Hiromitsu, Hino, Kunihiko, Takahashi, Kiyoshi, Muto, Yasutoshi, Yoshitane, Kosaka, Kawakami, Hiroiku, Suzuki, Shiro, Watanabe, Shozoh, Saito, Sumio, Koizumi, Masaru, Noda, Aiji, Kinugasa, Katsuhiko, Ogawa, Michio, Imamura, Koichiro, Yabe, Hideyuki, Sawabu, N., Yoneshima, M., Nishida, Koichi, Usami, Makoto, Yamamoto, Hisafumi, Saito, Shozo, Yamanaka, Takeo, Kimoto, Eizo, Tanaka, Yoshinori, Kasugai, Tatsuzo, Oi, Itaru, Takebe, Takaaki, Hayakawa, Tetsuo, Kozu, Tadahiko, Kitamura, Tsugio, Komatsu, Kanji, and Igimi, Hirotsune

Published
1982
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50. The Relationship between Gastric Secretion and Type of Early Gastric Carcinoma

Author

Yoshihara, Masaharu, Haruma, Ken, Sumii, Koji, Watanabe, Chiyuki, Kiyohira, Kuninushi, Kawaguchi, Hiroyuki, Tanaka, Shinji, and Kajiyama, Goro

Subjects
digestive, oral, and skin physiology, Gastric carcinoma, Serum gastrin, digestive system, digestive system diseases, Gastric acid secretion, Serum pepsinogen I
Abstract

To determine the relationship between gastric secretion and gastric carcinoma, we investigated gastric acid secretion and the fasting serum levels of pepsinogen I and gastrin in 50 Japanese patients with early gastric carcinoma. After the histological and macroscopic type of carcinoma had been determined, results were compared with findings in 50 Japanese control subjects whose gastric mucosa was endoscopically normal. The maximum gastric acid secretion and fasting levels of serum pepsinogen I were significantly lower in intestinal type gastric carcinoma than in diffuse type carcinoma and in the controls. They were also significantly lower in the non-ulcerative (elevated or flat) type than in the ulcerative (depressed) type of carcinoma. The serum gastrin levels in patients with early gastric carcinoma of either the intestinal or diffuse type were higher than those in the control subjects, though the difference was not significant. Gastric acid secretion and serum pepsinogen I levels were related with both the histological and macroscopic types of gastric carcinoma. These findings suggest that the serum pepsinogen I level might be useful as a maker for early gastric carcinoma of the intestinal type.

Published
1995

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