Search

Your search keyword '"Stolz S"' showing total 271 results
Start Over Author "Stolz S"
271 results on '"Stolz S"'

1. Reduction of neutrophilic lung inflammation by inhalation of the compatible solute ectoine: a randomized trial with elderly individuals

Author

Unfried K, Krämer U, Sydlik U, Autengruber A, Bilstein A, Stolz S, Marini A, Schikowski T, Keymel S, and Krutmann J

Subjects
osmolytes, extremolytes, molecular prevention, neutrophil apoptosis, SALIA cohort, air pollution, Diseases of the respiratory system, RC705-779
Abstract

Klaus Unfried,1,* Ursula Krämer,1,* Ulrich Sydlik,1 Andrea Autengruber,1 Andreas Bilstein,2 Sabine Stolz,1 Alessandra Marini,1 Tamara Schikowski,1 Stefanie Keymel,3 Jean Krutmann1 1IUF Leibniz Research Institute of Environmental Medicine, 2bitop AG, Witten, 3Department of Cardiology, Pneumology and Angiology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany *These authors contributed equally to this work Background: Compatible solutes are natural substances that are known to stabilize cellular functions. Preliminary ex vivo and in vivo studies demonstrated that the compatible solute ectoine restores natural apoptosis rates of lung neutrophils and contributes to the resolution of lung inflammation. Due to the low toxicity and known compatibility of the substance, an inhalative application as an intervention strategy for humans suffering from diseases caused by neutrophilic inflammation, like COPD, had been suggested. As a first approach to test the feasibility and efficacy of such a treatment, we performed a population-based randomized trial.Objective: The objective of the study was to test whether the daily inhalation of the registered ectoine-containing medical device (Ectoin® inhalation solution) leads to a reduction of neutrophilic cells and interleukin-8 (IL-8) levels in the sputum of persons with mild symptoms of airway disease due to lifelong exposure to environmental air pollution.Methods: A double-blinded placebo-controlled trial was performed to study the efficacy and safety of an ectoine-containing therapeutic. Prior to and after both inhalation periods, lung function, inflammatory parameters in sputum, serum markers, and quality-of-life parameters were determined.Results: While the other outcomes revealed no significant effects, sputum parameters were changed by the intervention. Nitrogen oxides (nitrate and nitrite) were significantly reduced after ectoine inhalation with a mean quotient of 0.65 (95% confidence interval 0.45–0.93). Extended analyses considering period effects revealed that the percentage of neutrophils in sputum was significantly lower after ectoine inhalation than in the placebo group (P=0.035) even after the washout phase.Conclusion: The current study is the first human trial in which the effects of inhaled ectoine on neutrophilic lung inflammation were investigated. Besides demonstrating beneficial effects on inflammatory sputum parameters, the study proves the feasibility of the therapeutic approach in an aged study group. Keywords: osmolytes, extremolytes, molecular prevention, neutrophil apoptosis, SALIA cohort, air pollution

Published
2016

2. Investigation of the \(\gamma \)-ray Properties of the \(2^+\) States in \(^{14}\)C

Author

Corbari, G., primary, Bottoni, S., additional, Ciemała, M., additional, Crespi, F.C.L., additional, Fornal, B., additional, Leoni, S., additional, Janssens, R.V.F., additional, Pain, S.D., additional, Siciliano, M., additional, Albanese, E., additional, Ayangeakaa, A.D., additional, Benzoni, G., additional, Carmichael, S., additional, Carpenter, M., additional, Chipps, K., additional, Cieplicka-Oryńczak, N., additional, Cizewski, A., additional, Copp, P., additional, Febbraro, M., additional, Forson, J., additional, Gamba, E., additional, Garland, H., additional, Gilardy, G., additional, Hooker, J., additional, Iskra, Ł.W., additional, Jayatissa, H., additional, Kondev, F., additional, Jones, K., additional, Jones, M.D., additional, Lauritsen, T., additional, Li, J., additional, Little, D., additional, Million, B., additional, Müller-Gatermann, C., additional, Palmisano, A., additional, Polettini, M., additional, Porzio, C., additional, Ratkiewicz, A., additional, Reviol, W., additional, Sensharma, N., additional, Seweryniak, D., additional, Sims, H., additional, Stolz, S., additional, Toomey, R., additional, Ummel, C., additional, Wieland, O., additional, Wilson, G., additional, Wu, J., additional, Zhu, S., additional, and Ziliani, S., additional

Published
2024
Full Text
View/download PDF

10. Growth Optimization and Device Integration of Narrow-Bandgap Graphene Nanoribbons

Author

Borin Barin G., Sun Q., Di Giovannantonio M., Du C.-Z., Wang X.-Y., Llinas J.P., Mutlu Z., Lin Y., Wilhelm J., Overbeck J., Daniels C., Lamparski M., Sahabudeen H., Perrin M.L., Urgel J.I., Mishra S., Kinikar A., Widmer R., Stolz S., Bommert M., Pignedoli C., Feng X., Calame M., Müllen K., Narita A., Meunier V., Bokor J., Fasel R., Ruffieux P., Borin Barin G., Sun Q., Di Giovannantonio M., Du C.-Z., Wang X.-Y., Llinas J.P., Mutlu Z., Lin Y., Wilhelm J., Overbeck J., Daniels C., Lamparski M., Sahabudeen H., Perrin M.L., Urgel J.I., Mishra S., Kinikar A., Widmer R., Stolz S., Bommert M., Pignedoli C., Feng X., Calame M., Müllen K., Narita A., Meunier V., Bokor J., Fasel R., and Ruffieux P.

Published
2022

14. ADHD.

Author

Stolz, S.

Published
2008

15. On-surface synthesis of organocopper metallacycles through activation of inner diacetylene moieties

Author

Cirera B., Riss A., Mutombo P., Urgel J.I., Santos J., Di Giovannantonio M., Widmer R., Stolz S., Sun Q., Bommert M., Fasel R., Jelínek P., Auwarter W., Martín, Nazario, Écija, David, Cirera B., Riss A., Mutombo P., Urgel J.I., Santos J., Di Giovannantonio M., Widmer R., Stolz S., Sun Q., Bommert M., Fasel R., Jelínek P., Auwarter W., Martín, Nazario, and Écija, David

Published
2021

16. Asymmetric Elimination Reaction on Chiral Metal Surfaces

Author

Stolz S., Danese M., Di Giovannantonio M., Urgel J.I., Sun Q., Kinikar A., Bommert M., Mishra S., Brune H., Gröning O., Passerone D., Widmer R., Stolz S., Danese M., Di Giovannantonio M., Urgel J.I., Sun Q., Kinikar A., Bommert M., Mishra S., Brune H., Gröning O., Passerone D., and Widmer R.

Published
2021

17. Studierfähigkeit von Berufsmaturandinnen und -maturanden

Author

Dernbach-Stolz, Stefanie, Eigenmann, Philipp, Kamm, Chantal; https://orcid.org/0000-0001-8568-5659, Kessler, Stefan; https://orcid.org/0000-0003-0298-4827, Dernbach-Stolz, S ( Stefanie ), Eigenmann, P ( Philipp ), Kamm, C ( Chantal ), Kessler, S ( Stefan ), Eberle, Franz, Dernbach-Stolz, Stefanie, Eigenmann, Philipp, Kamm, Chantal; https://orcid.org/0000-0001-8568-5659, Kessler, Stefan; https://orcid.org/0000-0003-0298-4827, Dernbach-Stolz, S ( Stefanie ), Eigenmann, P ( Philipp ), Kamm, C ( Chantal ), Kessler, S ( Stefan ), and Eberle, Franz

Abstract

Während der Übergang Gymnasium–Universität in den letzten Jahren häufig im Fokus der Aufmerksamkeit lag und immer wieder über Mängel bei der Studierfähigkeit von gymnasialen Maturandinnen und Maturanden berichtet wurde und wird, ist über die Studierfähigkeit von Berufsmaturandinnen und -maturanden an Fachhochschulen nur wenig zu lesen. Im Beitrag werden die besonderen Aspekte einer beschränkt-allgemeinen Studierfähigkeit als realisierbares Ziel der Berufsmaturitätsschule dargelegt und empirische Befunde zur Zielerreichung zusammengetragen, darunter auch eine eigene Untersuchung. Es zeigt sich, dass bei den wichtigen Studierkompetenzen Mathematik und Deutsch je nach Berufsmaturitätsrichtung noch (zu) grosse Lücken bestehen. Hingegen kann an einem Beispiel gezeigt werden, dass Berufsmaturandinnen und -maturanden in einem berufsnahen Fachbereich gegenüber ebenfalls in diesem Bereich theoretisch spezialisierten gymnasialen Maturandinnen und Maturanden einen Wissens- und Könnensvorsprung aufweisen, was wohl auf die berufliche Anwendungserfahrung in diesem Fachbereich zurückzuführen ist. Es wird ersichtlich, dass zusätzlich zur grösseren Evaluationsstudie der Schweizerischen Berufsbildungsämter-Konferenz in der ersten Hälfte des vergangenen Jahrzehnts eine breite Erfassung von Komponenten der beschränkt-allgemeinen Studierfähigkeit wünschbar wäre. Am Schluss des Beitrags werden Überlegungen zu möglichen Änderungen der Anforderungen an die Studierfähigkeit an Fachhochschulen in der Zukunft angestellt.

Published
2021

18. Transformationen von Arbeit, Beruf und Bildung in internationaler Betrachtung - Einleitung

Author

Dernbach-Stolz, Stefanie, Eigenmann, Philipp, Kamm, Chantal, Kessler, Stefan; https://orcid.org/0000-0003-0298-4827, Dernbach-Stolz, S ( Stefanie ), Eigenmann, P ( Philipp ), Kamm, C ( Chantal ), Kessler, S ( Stefan ), Dernbach-Stolz, Stefanie, Eigenmann, Philipp, Kamm, Chantal, Kessler, Stefan; https://orcid.org/0000-0003-0298-4827, Dernbach-Stolz, S ( Stefanie ), Eigenmann, P ( Philipp ), Kamm, C ( Chantal ), and Kessler, S ( Stefan )

Published
2021

19. Knabenhandarbeit oder: Die Geburt eines Schulfaches aus Wirtschaftskrise und Schulkritik

Author

Dernbach-Stolz, Stefanie, Eigenmann, Philipp, Kamm, Chantal; https://orcid.org/0000-0001-8568-5659, Kessler, Stefan; https://orcid.org/0000-0003-0298-4827, Dernbach-Stolz, S ( Stefanie ), Eigenmann, P ( Philipp ), Kamm, C ( Chantal ), Kessler, S ( Stefan ), Criblez, Lucien, Dernbach-Stolz, Stefanie, Eigenmann, Philipp, Kamm, Chantal; https://orcid.org/0000-0001-8568-5659, Kessler, Stefan; https://orcid.org/0000-0003-0298-4827, Dernbach-Stolz, S ( Stefanie ), Eigenmann, P ( Philipp ), Kamm, C ( Chantal ), Kessler, S ( Stefan ), and Criblez, Lucien

Abstract

Die Anfänge der institutionalisierten dualen Berufsbildung werden in der Schweiz meist mit dem Beginn der Berufsbildungssubventionen durch den Bund in den 1880er-Jahren verbunden, diese wiederum auf die Wirtschaftskrise seit den späten 1870er-Jahren zurückgeführt. Der Beitrag zeigt erstens, dass in diesem Kontext auch die Diskussionen um ein neues Schulfach, die Knabenhandarbeit, einsetzten, die eng mit einer Kritik an Lebensferne und Kopflastigkeit der im 19. Jahrhundert etablierten Volksschule verbunden war. Zweitens wird der Generalisierungsprozess von einem inhaltlichen Schulreformanliegen hin zur generellen Forderung nach Schulreformen und zum Arbeitsprinzip als Methodenreform nachgezeichnet. Die Etablierung der Knabenhandarbeit als Schulfach dient drittens dazu, einige allgemeine Mechanismen von Schulreformen zu thematisieren.

Published
2021

20. Das Schweizer Übergangssystem im Schatten der vielbeachteten Berufsbildung

Author

Dernbach-Stolz, Stefanie, Eigenmann, Philipp, Kamm, Chantal; https://orcid.org/0000-0001-8568-5659, Kessler, Stefan; https://orcid.org/0000-0003-0298-4827, Dernbach-Stolz, S ( Stefanie ), Eigenmann, P ( Philipp ), Kamm, C ( Chantal ), Kessler, S ( Stefan ), Dernbach-Stolz, Stefanie, Eigenmann, Philipp, Kamm, Chantal; https://orcid.org/0000-0001-8568-5659, Kessler, Stefan; https://orcid.org/0000-0003-0298-4827, Dernbach-Stolz, S ( Stefanie ), Eigenmann, P ( Philipp ), Kamm, C ( Chantal ), and Kessler, S ( Stefan )

Abstract

Wenn es um die Leistungen beruflicher Ausbildungssysteme im internationalen Vergleich geht, wird die Schweiz gemeinhin als Musterland präsentiert. Dabei wird häufig übersehen, dass sich an der Schnittstelle von der obligatorischen Schule in die nachobligatorische Berufs- und Allgemeinbildung in den letzten Jahren ein para-systemischer Bildungsbereich etabliert hat. Dieser Bildungsbereich dient der (insbesondere beruflichen) Integration eines wachsenden Anteils junger Erwachsener, denen ein Direkteintritt in die Sekundarstufe II nach der obligatorischen Schule verwehrt bleibt. Der Beitrag setzt sich zum Ziel, das Schattendasein eines solchen ‚Übergangssystems‘ in der Schweiz zu beleuchten und versucht das Phänomen des ungeordneten Übergangswesens in bildungssystemischer Perspektive theoretisch, historisch und anhand aktueller empirischer Befunde zu verorten. Vor dem Hintergrund zunehmend destandardisierter Bildungsbiografien sowie einer defizitär und kompensatorisch ausgerichteten bildungspolitischen Diskussion soll eine systemische Sichtweise ein differenzierteres Bild auf Übergänge ermöglichen.

Published
2021

21. Zur Dichotomie von Berufsbildung und Allgemeinbildung

Author

Dernbach-Stolz, Stefanie, Eigenmann, Philipp, Kamm, Chantal; https://orcid.org/0000-0001-8568-5659, Kessler, Stefan; https://orcid.org/0000-0003-0298-4827, Dernbach-Stolz, S ( Stefanie ), Eigenmann, P ( Philipp ), Kamm, C ( Chantal ), Kessler, S ( Stefan ), Reichenbach, Roland, Dernbach-Stolz, Stefanie, Eigenmann, Philipp, Kamm, Chantal; https://orcid.org/0000-0001-8568-5659, Kessler, Stefan; https://orcid.org/0000-0003-0298-4827, Dernbach-Stolz, S ( Stefanie ), Eigenmann, P ( Philipp ), Kamm, C ( Chantal ), Kessler, S ( Stefan ), and Reichenbach, Roland

Abstract

Der Beitrag kritisiert nicht die offenbar erfolgreiche Idee und Tradition des „dualen“ Bildungssystems, das eine institutionelle Trennung von Allgemeinbildung und Berufsbildung vorsieht, sondern hinterfragt aus bildungstheoretischer Perspektive die Gewohnheiten eines dichotomischen Denkens, das mit dieser Trennung verbunden sein kann. Die Grundlage der Betrachtungen sind die wenig triftigen Gründe, mit denen – nur scheinbar – begrifflich zwischen allgemeiner und besonderer Bildung unterschieden wird. Dabei wird von der schon früh artikulierten Einsicht ausgegangen, dass es eine allgemeine Bildung ohne Bezug zum Besonderen eben so wenig wie eine besondere Bildung ohne Bezug zum Allgemeinen geben kann, und die phänomenale Welt nicht in allgemeine Gegenstände einerseits und besondere Gegenstände andererseits (feinsäuberlich) unterteilt ist. Die (begriffs-) analytische Trennung, die ihren Erkenntniswert ganz sicher vorweisen kann, verleitet gleichzeitig wohl allzu oft zur wenig plausiblen Ansicht, das Amalgam der Bildung und des Bildungsprozesses sei in seine Momente unterteilbar. Angesichts der sozialen, politischen, ökonomischen, rechtlichen, aber auch individuell-biografischen und ästhetischen Konsequenzen bzw. Wirkungen solcher Trennungen und den damit verbundenen Denkgewohnheiten ist es nicht nur legitim, sondern bildungsphilosophisch vielmehr auch gefordert, scheinbare Alternativlosigkeiten zu befragen. Dies führt weder logisch noch ethisch zum Schluss, die duale Konzeption sei abzulehnen, kann aber Anlass sein, die Gemeinsamkeit aller Bildungsprozesse nicht aus dem Auge zu verlieren.

Published
2021

22. Melanopsin signalling in mammalian iris and retina

Author

Xue, T., Do, M.T.H., Riccio, A., Jiang, Z., Hsieh, J., Wang, H.C., Merbs, S.L., Welsbie, D.S., Yoshioka, T., Weissgerber, P., Stolz, S., Flockerzi, V., Freichel, M., Simon, M.I., Clapham, D.E., and Yau, K.-W.

Subjects
Retina -- Physiological aspects -- Research, Melanopsin -- Physiological aspects -- Research, Iris (Eye) -- Physiological aspects -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Non-mammalian vertebrates have an intrinsically photosensitive iris and thus a local pupillary light reflex (PLR). In contrast, it is thought that the PLR in mammals generally requires neuronal circuitry connecting the eye and the brain. Here we report that an intrinsic component of the PLR is in fact widespread in nocturnal and crepuscular mammals. In mouse, this intrinsic PLR requires the visual pigment melanopsin; it also requires PLCβ4, a vertebrate homologue of the Drosophila NorpA phospholipase C which mediates rhabdomeric phototransduction. The [Plcb4.sup.-/-] genotype, in addition to removing the intrinsic PLR, also essentially eliminates the intrinsic light response of the M1 subtype of melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (M1-ipRGCs), which are by far the most photosensitive ipRGC subtype and also have the largest response to light. Ablating in mouse the expression of both TRPC6 and TRPC7, members of the TRP channel superfamily, also essentially eliminated the M1-ipRGC light response but the intrinsic PLR was not affected. Thus, melanopsin signalling exists in both iris and retina, involving a PLCβ4-mediated pathway that nonetheless diverges in the two locations., The discovery of ipRGCs has overturned the century-old belief that rods and cones are the only mammalian retinal photoreceptors (1-6). These ganglion-cell photoreceptors serve primarily non-image visual functions, one of [...]

Published
2011
Full Text
View/download PDF

25. P09.03 Cathepsin S alterations induce a tumor-promoting immune microenvironment in follicular lymphoma

Author

Hildebrand, JA, primary, Bararia, D, additional, Stolz, S, additional, Häbe, S, additional, Osorio-Barrios, F, additional, Bartoschek, MD, additional, Gaitzsch, E, additional, Jurinovic, V, additional, Rautter, K, additional, Ludwig, C, additional, Bultmann, S, additional, Leonhardt, H, additional, Eustermann, S, additional, Hopfner, K, additional, Hiddemann, W, additional, Bergwelt, M, additional, Schmidt-Supprian, M, additional, Sárosi, MB, additional, Rudelius, M, additional, Passerini, V, additional, Mautner, J, additional, and Weigert, O, additional

Published
2020
Full Text
View/download PDF

28. IPC-KompAKT – InterProfessional Collaboration – Kompetent als Klinisches Team – Ein Kurs zur interprofessionellen Ausbildung an der Ludwig-Maximilians-Universität München

Author

Beer, D, von Brauchitsch, S, Grill, J, Leberzammer, J, Loiko, V, Plett, C, Schaller, J, Sigl, S, Stolz, S, Tossounidis, J, Wach, K, Wróbel, P, and Fischer, MR

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Interprofessionelle Zusammenarbeit (IPC) im Gesundheitswesen ist essentiell für eine optimale Patientenversorgung. Mit dem daraus resultierenden Bedarf an interprofessioneller Ausbildung (IPE) befassten sich 12 Studierende der Medizin im Rahmen des MeCuM StEP Programms der medizinischen[zum vollständigen Text gelangen Sie über die oben angegebene URL], Gemeinsame Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA), des Arbeitskreises zur Weiterentwicklung der Lehre in der Zahnmedizin (AKWLZ) und der Chirurgischen Arbeitsgemeinschaft Lehre (CAL)

Published
2019
Full Text
View/download PDF

34. Studie zu den Auswirkungen von Luftverschmutzung auf Geruchsidentifikation und kognitive Leistung

Author

Merz, H, Hüls, A, Hoffmann, B, Stolz, S, Vierkötter, A, Krämer, U, and Schikowski, T

Subjects
ddc: 610, Neurologic and mental health epidemiology, Environmental epidemiology, 610 Medical sciences, Medicine
Abstract

Hintergrund: Luftverschmutzung hat eine Vielzahl von Auswirkungen auf den menschlichen Organismus. Mehrere Studien konnten Zusammenhänge zwischen chronischer Luftverschmutzung mit kardiovaskulären- und respiratorischen Erkrankungen aufzeigen und es gab in den letzten Jahren auch erste Hinweise[zum vollständigen Text gelangen Sie über die oben angegebene URL], HEC 2016: Health – Exploring Complexity; Joint Conference of GMDS, DGEpi, IEA-EEF, EFMI

Published
2016
Full Text
View/download PDF

35. Management of phenylketonuria in Europe: Survey results from 19 countries

Author

Ozturk, YEŞİM, Niinikoski, H., Bonnemains, C., Marioli, S., Barat, P., De Parscau, L., Meyer, M., Bedu, A., Güttler, F., Pazdirkova, R., Prochazkova, D., Sarnavka, V., Baric, I., Toromanovic, A., Tahirovic, H., Scholl-Bürgi, S., Karall, D., Van Spronsen, F.J., Trefz, Friedrich K., Giovannini, Marcello, Feillet, François, Demirkol, M., Bélanger-Quintana, A., Blau, Nenad, Aydin, H., Coskun, T., Dursun, A., Kalkanoglu, S.H.S., Tokatli, A., Eminoglu, F.T., Hasanoglu, A., Baumgartner, M., Onenli-Mungan, N., Yüksel, B., Gil-Ortega, D., Odent, S., Eyer, D., Labarthe, F., Hennermann, J.B., Mönch, E., Stolz, S., Spiekerkötter, U., Knerr, I., Schwab, K.O., Kreuder, J., Ullrich, K., Das, A.M., Burgard, P., Kon-Stantopoulou, V., Lindner, M., Müller, E., Haase, C., Beblo, S., Weigel, J., Plötzch, S., Muntau, A., Weglage, J., Marquardt, J., Scheible, D., Clemens, P., Schulpis, K.H., Papadia, F., Salardi, S., Meli, C., Donati, M.A., Procopio, E., Cerone, R., Riva, E., Giovannini, M., Paci, S., Carbone, M.T., Burlina, A., Lapichino, L., Cotugno, G., Leuzzi, V., Rubio-Gozalbo, E., De Vries, M., De Klerk, J.B.C., Walter, J., Cleary, M.A., Schwann, B., Robinson, P., Galloway, P., Hendriksz, C.J., Iversen, K., Wiig, I., Jørgensen, J., Milanowski, A., Nowacka, M., Djordjevic, M., Laketa, C., Gutiérrez-Junquera, C., Márquez-Armenteros, A., Vilaseca Busca, M.A., Campistol Plana, J., Peña-Quintana, L., Valverde, F.S., Gonzalez-Lamuno, D., Couce-Pico, M.L., Dalmau Serra, J., Baldellou-Vazquez, A., Garcia-Jimenez, M.C., Papadopoulou, D., Almm, J., Okur, I., Süheyl, E.F., Tumer, L., Aydogdu, S., Aktuglu-Zeybek, A.C., Cansever, S., Arslan, N., Erdur, B., Coker, M., Kalkan, U.S., Hizel-Bülbül, S., Tanzer, F., MacDonald, Anita, MacDonald, A., Chakrapani, A., Gomez, A.R., Fouilhoux, A., Chabrol, B., Wagner, K., Billette De Villemeur, T., De Lonlay-Debeney, P., Ogier De Baulny, H., Halldin Stenlid, M., Nuoffer, J.M., Rohrbach, M., Faculteit Medische Wetenschappen/UMCG, Center for Liver, Digestive and Metabolic Diseases (CLDM), Kindergeneeskunde, RS: GROW - School for Oncology and Reproduction, University of Zurich, and Blau, N

Subjects
Dieticians, Pediatrics, 1303 Biochemistry, phenylalanine, Endocrinology, Diabetes and Metabolism, Prevalence, CHILDREN, Biochemistry, RECOMMENDATIONS, Endocrinology, Hyperphenylalaninemia, DIETARY CONTROL, Phenylketonurias, Surveys and Questionnaires, Epidemiology, Registries, guidelines, BH4, 1310 Endocrinology, Europe, 2712 Endocrinology, Diabetes and Metabolism, Child, Preschool, 10076 Center for Integrative Human Physiology, CONCURRENT PHENYLALANINE LEVELS, PKU, Adult, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Health Planning Guidelines, NEUTRAL AMINO-ACIDS, MEDLINE, 610 Medicine & health, Survey result, 1311 Genetics, Age groups, 1312 Molecular Biology, Genetics, medicine, Humans, Molecular Biology, hyperphenylalaninemia, business.industry, Infant, Newborn, nutritional and metabolic diseases, bh4, diet, pku, Guideline, medicine.disease, TRANSPORT, phenylketonuria, European countries, tetrahydrobiopterin, 10036 Medical Clinic, Health Care Surveys, 570 Life sciences, biology, business, Follow-Up Studies
Abstract

To gain better insight in the most current diagnosis and treatment practices for phenylketonuria (PKU) from a broad group of experts, a European PKU survey was performed. The questionnaire, consisting of 33 questions, was sent to 243 PKU professionals in 165 PKU centers in 23 European countries. The responses were compiled and descriptive analyses were performed. One hundred and one questionnaires were returned by 93/165 centers (56%) from 19/23 European countries (83%). The majority of respondents (77%) managed patients of all age groups and more than 90% of PKU teams included physicians or dieticians/nutritionists. The greatest variability existed especially in the definition of PKU phenotypes, therapeutic blood phenylalanine (Phe) target concentrations, and follow-up practices for PKU patients. The tetrahydrobiopterin (BH4 ; sapropterin) loading test was performed by 54% of respondents, of which 61% applied a single dose test (20mg/kg over 24h). BH4 was reported as a treatment option by 34%. This survey documents differences in diagnostic and treatment practices for PKU patients in European centers. In particular, recommendations for the treatment decision varied greatly between different European countries. There is an urgent need to pool long-term data in PKU registries in order to generate an evidence-based international guideline. Copyright (c) 2009 Elsevier Inc. All rights reserved.

Published
2010

36. Large-eddy simulation of transition in wall-bounded flow

Author

Schlatter, P., Stolz, S., and Kleiser, L.

Subjects
ラージエディシミュレーション, 圧縮性流れ, turbulent flow, 境界層遷移, Tollmien-Schlichting wave, トルミーン-シュリヒティング波, shear flow, laminar-turbulent transition, 遷移流, せん断流, turbulence, ヘアピン渦, large eddy simulation, channel flow, 乱流場, hairpin vortice, Physics::Fluid Dynamics, チャネル流, 乱流, 層流-乱流遷移, boundary layer transition, compressible flow, transition flow
Abstract

Laminar-turbulent transition is a crucial phenomenon appearing in a variety of industrial applications. However the involved physical mechanisms as well as methods for reliable and accurate prediction of transition are still a matter of active research. In the present contribution, we give a brief overview on recent advances in the simulation and prediction of transitional and turbulent wall-bounded shear flows. The focus is on Large-Eddy Simulations (LES), which differ from Direct Numerical Simulations (DNS) by resolving only the large-scale, energy-carrying vortices of the fluid flow, whereas the fine-scale fluid oscillations, assumed to be more homogeneous, are treated by a SubGrid-Scale (SGS) model. The application of LES to flows of technical interest is promising and LES is getting more and more applied to practical problems. The main reason for this is that LES provides an increased accuracy compared to solutions of the (statistical) Reynolds-Averaged Navier-Stokes equations (RANS), while requiring only a fraction of the computational cost of a corresponding fully-resolved DNS. Nevertheless, LES of practical transitional and turbulent flows still require massive computational resources and the use of large-scale computer facilities., 資料番号: AA0063908005, レポート番号: JAXA-SP-07-026E

Published
2008

39. Work, Education and Employability - Introduction

Author

Gonon, P, Kraus, K, Oelkers, J, Stolz, S, Gonon, P ( P ), Kraus, K ( K ), Oelkers, J ( J ), Stolz, S ( S ), Kraus, Katrin; https://orcid.org/0000-0002-3847-4514, Gonon, Philipp, Oelkers, Jürgen, Dernbach-Stolz, Stefanie, Gonon, P, Kraus, K, Oelkers, J, Stolz, S, Gonon, P ( P ), Kraus, K ( K ), Oelkers, J ( J ), Stolz, S ( S ), Kraus, Katrin; https://orcid.org/0000-0002-3847-4514, Gonon, Philipp, Oelkers, Jürgen, and Dernbach-Stolz, Stefanie

Published
2008

40. Kidney transplantation in patients with Fabry disease

Author

Cybulla M, Walter KN, Schwarting A, Divito R, Feriozzi S, Sunder Plassmann G, Binder C, Kotanko P, Kroepfl T, Plecko B, Bodamer O, Hauser AC, Kleinert J, Kristoferitsch W, Schreiber W, Georges B, Nassogne MC, Pirson Y, Dehout F, Henry F, Roland D, Vauthier L, Goyens P, Mazoin N, Van Maldergem L, Eyskens F, Bultas J, Karetová D, Linhart A, Dostalova G, Choukroun G, Berthelot J, Hardy P, Carey Reomonnay S, Lacombe D, Bataille P, Benziane S, Mittelberger JM, Thevenot C, Dobbelaere D, Hachulla E, Dussol B, Reade R, Khau van Kien A, Kaminsky P, Guyot C, Lino M, Ghafari T, Germain DP, Knebelmann B, Lidove O, Ouali N, Touati G, Monlun E, Jaussaud R, Richalet B, Klotz V, Andres E, Caraman D, Bazex J, Perrichot R, Hennermann J, von Arnim Baas A, Stolz S, Hoffmann B, Chrobot E, Grabbe S, Jansen T, Neumann HP, Schluh G, Gal A, Muschol N, Shäfer E, Ullrich K, Das A, Illsinger S, Lücke T, Bähner F, Baron K, Beck M, Bruns K, Delgado Sanchez S, Hartung R, Kalkum G, Kampmann C, Keilmann A, Lackner K, Pitz S, Whybra C, Wiethoff C, Koletzko B, Pontz B, Böttcher T, Miethe S, Rolfs A, Davydenko I, Wanner C, Maródi L, Gabrielli O, Gobbi S, Concolino D, Zampetti A, Borsini W, Buchner S, Menni F, Parini R, Ravaglia R, Santus F, Di Vito R, Burlina A, Burlina AP, Manara R, Antuzzi D, Castorina M, Ricci R, Kaarbøe Ø, Skarbøvik A, Houge G, Svarstad E, Tøndel C, Barba MA, Botella R, Franco A, Torras J, Gómez Huertas E, Torregrosa V, Fernández V, Paniagua J, Rodriguez F, Herrera J, Febrer I, Perez Garcia A, Martin I, Barbado FJ, Garcia de Lorenzo A, López M, González J, Ballarin J, Torra R, Hernández S, Ara J, Bonal J, Pintos G, Andreu J, Rivera A, Oqvist B, Huyen Do U, Barbey F, Hayoz D, Theytaz J, Schärer M, Schulthess G, Steinmann B, Walter K, Widmer U, Hollak C, Ormel E, van Duinen A, Vetter A, Corcoran M, Cox TM, Deegan P, Ramaswami U, Wright N, Baker R, Blincoe M, Bruce R, Burns A, Close L, Davey C, Elliott J, Elliott P, Evans S, Ginsberg L, Hajioff D, Hughes D, Ioannidis A, Keshav S, Mehta A, Milligan A, Orteu C, Richfield L., STRISCIUGLIO, PIETRO, Cybulla, M, Walter, Kn, Schwarting, A, Divito, R, Feriozzi, S, Sunder Plassmann, G, Binder, C, Kotanko, P, Kroepfl, T, Plecko, B, Bodamer, O, Hauser, Ac, Kleinert, J, Kristoferitsch, W, Schreiber, W, Georges, B, Nassogne, Mc, Pirson, Y, Dehout, F, Henry, F, Roland, D, Vauthier, L, Goyens, P, Mazoin, N, Van Maldergem, L, Eyskens, F, Bultas, J, Karetová, D, Linhart, A, Dostalova, G, Choukroun, G, Berthelot, J, Hardy, P, Carey Reomonnay, S, Lacombe, D, Bataille, P, Benziane, S, Mittelberger, Jm, Thevenot, C, Dobbelaere, D, Hachulla, E, Dussol, B, Reade, R, Khau van Kien, A, Kaminsky, P, Guyot, C, Lino, M, Ghafari, T, Germain, Dp, Knebelmann, B, Lidove, O, Ouali, N, Touati, G, Monlun, E, Jaussaud, R, Richalet, B, Klotz, V, Andres, E, Caraman, D, Bazex, J, Perrichot, R, Hennermann, J, von Arnim Baas, A, Stolz, S, Hoffmann, B, Chrobot, E, Grabbe, S, Jansen, T, Neumann, Hp, Schluh, G, Gal, A, Muschol, N, Shäfer, E, Ullrich, K, Das, A, Illsinger, S, Lücke, T, Bähner, F, Baron, K, Beck, M, Bruns, K, Delgado Sanchez, S, Hartung, R, Kalkum, G, Kampmann, C, Keilmann, A, Lackner, K, Pitz, S, Whybra, C, Wiethoff, C, Koletzko, B, Pontz, B, Böttcher, T, Miethe, S, Rolfs, A, Davydenko, I, Wanner, C, Maródi, L, Gabrielli, O, Gobbi, S, Concolino, D, Strisciuglio, Pietro, Zampetti, A, Borsini, W, Buchner, S, Menni, F, Parini, R, Ravaglia, R, Santus, F, Di Vito, R, Burlina, A, Burlina, Ap, Manara, R, Antuzzi, D, Castorina, M, Ricci, R, Kaarbøe, Ø, Skarbøvik, A, Houge, G, Svarstad, E, Tøndel, C, Barba, Ma, Botella, R, Franco, A, Torras, J, Gómez Huertas, E, Torregrosa, V, Fernández, V, Paniagua, J, Rodriguez, F, Herrera, J, Febrer, I, Perez Garcia, A, Martin, I, Barbado, Fj, Garcia de Lorenzo, A, López, M, González, J, Ballarin, J, Torra, R, Hernández, S, Ara, J, Bonal, J, Pintos, G, Andreu, J, Rivera, A, Oqvist, B, Huyen Do, U, Barbey, F, Hayoz, D, Theytaz, J, Schärer, M, Schulthess, G, Steinmann, B, Walter, K, Widmer, U, Hollak, C, Ormel, E, van Duinen, A, Vetter, A, Corcoran, M, Cox, Tm, Deegan, P, Ramaswami, U, Wright, N, Baker, R, Blincoe, M, Bruce, R, Burns, A, Close, L, Davey, C, Elliott, J, Elliott, P, Evans, S, Ginsberg, L, Hajioff, D, Hughes, D, Ioannidis, A, Keshav, S, Mehta, A, Milligan, A, Orteu, C, and Richfield, L.

Published
2009

41. Efficient second-order time integration for single-species aerosol formation and evolution

Author

Winkelmann, C, Nordlund, M., Kuczaj, A.K., Stolz, S, Geurts, B.J., and Fluids and Flows

Subjects
METIS-303991, EWI-24298, IR-88882
Abstract

The dynamics of a single-species aerosol composed of droplets in air is described in terms of nucleation, evaporation, condensation, and coagulation processes. We present a comprehensive overview of the Euler-Euler formulation, which gives rise to a model in which fast nucleation that initiates aerosol droplets co-exists with comparably slow condensation. The latter process is responsible for the subsequent growth of the droplets. To accurately represent the dynamical consequences of the fast nucleation process, while retaining numerical efficiency, a new second-order time-integration method for the nucleation, evaporation, and condensation processes is proposed and analyzed. The new time-integration method takes the form of a corrected Euler forward' method. It includes rapid nucleation bursts and their possible cessation within a time step t. If the current nucleation burst persists for longer than the next time step, it is included fully, whereas cessation of the nucleation burst within the next t implies corrections to the effective rates in the algorithm. The identification of these two situations corresponds to the physical mechanism by which nucleation of a supersaturated vapor is halted because of the progressing condensation onto the already formed droplets. The resulting time-integration method is shown to be second-order accurate in time, whereas the computational costs per time step were found to be increased by less than 25% compared with the Euler forward method. The new method is also applied in combination with advective transport of the aerosol forming vapor to investigate a front of rapid nucleation. Adopting robust first-order upwinding for the spatial discretization, we arrive at a flexible method that shows an overall first-order convergence in t. For the full, spatially dependent system motivated by an aerosol of water droplets in air, the computational benefits of the new time-integration method over the Euler forward scheme, are a factor of about 10 improvements in accuracy at a given t and a similar factor in computing time when keeping the same level of accuracy. Copyright (c) 2013 John Wiley & Sons, Ltd.

Published
2014

45. Large-eddy simulation of transition in wall-bounded flow

Author

Schlatter, P., Stolz, S., Kleiser, L., Schlatter, P., Stolz, S., and Kleiser, L.

Abstract

Laminar-turbulent transition is a crucial phenomenon appearing in a variety of industrial applications. However the involved physical mechanisms as well as methods for reliable and accurate prediction of transition are still a matter of active research. In the present contribution, we give a brief overview on recent advances in the simulation and prediction of transitional and turbulent wall-bounded shear flows. The focus is on Large-Eddy Simulations (LES), which differ from Direct Numerical Simulations (DNS) by resolving only the large-scale, energy-carrying vortices of the fluid flow, whereas the fine-scale fluid oscillations, assumed to be more homogeneous, are treated by a SubGrid-Scale (SGS) model. The application of LES to flows of technical interest is promising and LES is getting more and more applied to practical problems. The main reason for this is that LES provides an increased accuracy compared to solutions of the (statistical) Reynolds-Averaged Navier-Stokes equations (RANS), while requiring only a fraction of the computational cost of a corresponding fully-resolved DNS. Nevertheless, LES of practical transitional and turbulent flows still require massive computational resources and the use of large-scale computer facilities., JAXA Special Publication, 宇宙航空研究開発機構特別資料

Published
2015

49. A Genealogical Analysis of the Concept of ‘Good’ Teaching: A Polemic.

Author

STOLZ, S. T. E. V. E. N. A.

Subjects
*GENEALOGY, *HUMAN beings, *EFFECTIVE teaching, *EDUCATION, *HIGHER education, *PROFESSIONAL education
Abstract

Abstract: In this essay I intentionally employ Nietzsche's genealogical method as a means to critique the complex concept of ‘good’ teaching, and at the same time reconstitute ‘good’ teaching in a form that is radically different from contemporary accounts. In order to do this, I start out by undertaking a genealogical analysis to both reveal the complicated historical development of ‘good’ teaching and also disentangle the intertwining threads that remain hidden from us so we are aware of the core threads that hold it together. Two major threads are identified in my analysis, which I refer to as: Genealogy I: Teaching as applied science or practice; and, Genealogy II: Teaching as a vocational calling or neutral profession. With this in mind, I take the two value systems (Genealogy I and II) presented in my critique of ‘good’ teaching, and rather than return to old, or create new values, I argue that the true task of any educational endeavour is to make human beings human. Therefore, in the spirit of Nietzsche, I revive and extend Nietzsche's account of Bildung as a dynamic way of living timeless educational aims, such as learning to see, think, speak, write and feel in becoming true human beings. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

50. Physically consistent simulation of transport of inertial particles in porous media

Author

Ghazaryan, L., Lopez Penha, D.J., Geurts, Bernardus J., and Stolz, S.

Subjects
Physics::Fluid Dynamics, Porous media, EWI-19579, IR-79558, Particle filtration, Lagrangian transport model, Slow flow, METIS-284892
Abstract

A new numerical approach is presented for simulating the movement of test particles suspended in an incompressible fluid flowing through a porous matrix. This two-phase particle-laden flow is based on the Navier-Stokes equations for incompressible fluid flow and equations of motion for the individual particles in which Stokes drag is dominant. The Immersed Boundary method is applied to incorporate the geometric complexity of the porous medium. A symmetry-preserving finite volume discretization method in combination with a volume penalization method resolves the flow within the porous material. The new Lagrangian particle tracking is such that for mass-less test particles no (numerical) collision with the coarsely represented porous medium occurs at any spatial resolution.

Published
2011

Catalog

Books, media, physical & digital resources
See catalog results