399 results on '"Spadari, Silvio"'
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2. Functional Roles of DNA Polymerases β and γ
3. RNA-Primed DNA Synthesis: Specific Catalysis by HeLa Cell DNA Polymerase α
4. Variations of DNA polymerases-α and -β during Prolonged Stimulation of Human Lymphocytes
5. Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663
6. Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation
7. Hepatitis C virus NS3 ATPase/helicase: an ATP switch regulates the cooperativity among the different substrate binding sites
8. Eukaryotic DNA polymerases
9. Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase [delta] by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1
10. Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the “primer grip” region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants
11. Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases β and λ
12. Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase λ
13. Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases β and λ
14. Uracil in Oris of herpes simplex 1 alters its specific recognition by origin binding protein (OBP): does virus induced uracil-DNA glycosylase play a key role in viral reactivation and replication?
15. Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2′-azido-2′-deoxynucleosides
16. Mutagenesis of human DNA polymerase λ: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities
17. Nevirapine-selected mutations Y181I/C of HIV-1 reverse transcriptase confer cross-resistance to stavudine
18. DNA replication and chemotherapy
19. Aphidicolin and Eukaryotic DNA Synthesis
20. Research on anti-HIV-1 agents. Part 2: Solid-phase synthesis, biological evaluation and molecular modeling studies of 2,5,6-trisubstituted-4(3H)-pyrimidinones targeting HIV-1 reverse transcriptase
21. Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: Role of the 3′-hydroxyl group of the L-(β)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs
22. On the Mechanism of Ultraviolet-Induced Mutagenesis
23. Neurons as a Model System for In Vivo Studies of the Possible Function of DNA Polymerases in DNA Replication and Repair Synthesis During Development
24. The Three DNA Polymerases of Animal Cells: Properties and Functions
25. Human DNA Polymerases
26. Human DNA polymerase lambda deverged in evolution from DNA polymerase beta toward specific Mn (super)++ dependence: a kinetic and thermodynamic study
27. New in silico and conventional in vitro approaches to advance HIV drug discovery and design
28. N2-Phenyl-9-(hydroxyalkyl)guanines and related compounds are substrates for Herpes simplex virus thymidine kinases
29. Proteins Involved in DNA Replication
30. Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases β and λ
31. Design and Synthesis of Phosphonoacetic Acid (PPA) Ester and Amide Bioisosters of Ribofuranosylnucleoside Diphosphates as Potential Ribonucleotide Reductase Inhibitors and Evaluation of their Enzyme Inhibitory, Cytostatic and Antiviral Activity
32. New in silico and conventional in vitro approaches to advance HIV drug discovery and design
33. DNA Polymerases
34. Sensitivity of Monkey B Virus ( Cercopithecine herpesvirus 1) to Antiviral Drugs: Role of Thymidine Kinase in Antiviral Activities of Substrate Analogs and Acyclonucleosides
35. Slow‐, Tight‐Binding HIV‐1 Reverse Transcriptase Non‐Nucleoside Inhibitors Highly Active against Drug‐Resistant Mutants
36. Human DEAD-box ATPase DDX3 shows a relaxed nucleoside substrate specificity
37. Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate
38. High Potency of Indolyl Aryl Sulfone Nonnucleoside Inhibitors towards Drug-Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutants Is Due to Selective Targeting of Different Mechanistic Forms of the Enzyme
39. Specific Targeting Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. Design, Synthesis, and Biological Evaluation of Novel, Potent, and Broad Spectrum NNRTIs with Antiviral Activity
40. Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants
41. Diketo Hexenoic Acid Derivatives Are Novel Selective Non-Nucleoside Inhibitors of Mammalian Terminal Deoxynucleotidyl Transferases, with Potent Cytotoxic Effect against Leukemic Cells
42. Inhibition of Herpes Simplex Virus Thymidine Kinases by 2-Phenylamino-6-oxopurines and Related Compounds: Structure−Activity Relationships and Antiherpetic Activity in Vivo
43. Microwave‐Assisted Synthesis and Biological Evaluation of Novel Uracil Derivatives Inhibiting Human Thymidine Phosphorylase.
44. Drug Resistance Mutations in the Nucleotide Binding Pocket of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Differentially Affect the Phosphorolysis-Dependent Primer Unblocking Activity in the Presence of Stavudine and Zidovudine and Its Inhibition by Efavirenz
45. DNA Elongation by the Human DNA Polymerase λ Polymerase and Terminal Transferase Activities Are Differentially Coordinated by Proliferating Cell Nuclear Antigen and Replication Protein A
46. Gln145Met/Leu Changes in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confer Resistance to Nucleoside and Nonnucleoside Analogs and Impair Virus Replication
47. Vif is an auxiliary factor of the HIV-1 reverse transcriptase and facilitates abasic site bypass
48. The human DNA polymerase λ interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21 /WAF1/CIP1
49. Human DNA Polymerases λ and β Show Different Efficiencies of Translesion DNA Synthesis past Abasic Sites and Alternative Mechanisms for Frameshift Generation
50. Effects of Drug Resistance Mutations L100I and V106A on the Binding of Pyrrolobenzoxazepinone Nonnucleoside Inhibitors to the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Catalytic Complex
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