Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663

Authors :: Maga, Giovanni
Gemma, Sandra
Fattorusso, Caterina
Nacci, Vito
Spadari, Silvio
Campiani, Giuseppe
Locatelli, Giada A.
Savini, Luisa
Novellino, Ettore
Butini, Stefania
Persico, Marco
Kukreja, Gagan
Romano, Maria Pia
Chiasserini, Luisa
Source :: Biochemistry. July 19, 2005, Vol. 44 Issue 28, p9637, 8 p.
Publication Year :: 2005
Abstract: A thorough molecular modeling study was carried out to explain the molecular basis of nonstructural protein 3 RNA helicase (NS3h) inhibition by QU663 which is one of a new generation of small-molecule nucleotide-mimicking inhibitors which are also potential anti-hepatitis C virus (HCV) agents. The resulting three-dimensional interaction model is discussed.

Subjects :: Molecular dynamics -- Research
Hepatitis C virus -- Research
Proteins -- Structure
Proteins -- Research
Biological sciences
Chemistry

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