45 results on '"Soylu, Hikmet"'
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2. Identifying Clinical Characteristics of Hypoparathyroidism in Turkey: HIPOPARATURK-NET Study
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Konca Degertekin, Ceyla, Gogas Yavuz, Dilek, Pekkolay, Zafer, Saygili, Emre, Ugur, Kader, Or Koca, Arzu, Unubol, Mustafa, Topaloglu, Omercan, Aydogan, Berna Imge, Ozdemir Kutbay, Nilufer, Hekimsoy, Zeliha, Yilmaz, Nusret, Balci, Mustafa Kemal, Tanrikulu, Seher, Aydogan Unsal, Yasemin, Ersoy, Canan, Omma, Tulay, Keskin, Muge, Yalcin, Mehmet Muhittin, Yetkin, Ilhan, Soylu, Hikmet, Karakose, Melia, Yilmaz, Merve, Karakilic, Ersen, Piskinpasa, Hamide, Batman, Adnan, Akbaba, Gulhan, Elbuken, Gulsah, Tura Bahadir, Cigdem, Kilinc, Faruk, Bilginer, Muhammet Cuneyt, Turhan Iyidir, Ozlem, Canturk, Zeynep, Aktas Yilmaz, Banu, Sayiner, Zeynel Abidin, and Eroglu, Mustafa
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- 2022
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3. Biochemical characteristics and calcium and PTH levels of patients with high normal and elevated serum 25(OH)D levels in Turkey: DeVIT-TOX survey
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Pekkolay, Zafer, Yavuz, Dilek Gogas, Saygılı, Emre Sedar, Değertekin, Ceyla Konca, Topaloğlu, Ömercan, Önder, Çağatay Emir, Soylu, Hikmet, Taskaldıran, Işılay, Pazır, Ayşe Esen, Uğur, Kader, Tanrıkulu, Seher, Fırat, Sevde Nur, Atak, Burcu Meryem, Batman, Adnan, Omma, Tülay, Cağıltay, Eylem, Özdemir, Nilüfer, Altuntaş, Seher Çetinkaya, İmga, Narin Nasıroğlu, Karakılıç, Ersen, Hekimsoy, Zeliha, Kılınç, Faruk, Yay, Adnan, Eroğlu, Mustafa, and Tuzcu, Alpaslan Kemal
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- 2021
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4. A comparison of intensive insulin therapy and dipeptidyl peptidase-4 inhibitor plus metformin combination in newly diagnosed type 2 diabetes mellitus.
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DIRI, Halit, BOLAYIR, Basak, SOYLU, Hikmet, CETIN, Sedat, and SIMSEK, Mehmet
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- 2024
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5. A comparison of intensive insulin therapy and dipeptidyl peptidase-4 inhibitor plus metformin combination in newly diagnosed type 2 diabetes mellitus
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DIRI, Halit, primary, BOLAYIR, Basak, additional, SOYLU, Hikmet, additional, CETIN, Sedat, additional, and SIMSEK, Mehmet, additional
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- 2023
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6. A MEN-2A Case Developing Transient Adrenal Insufficiency after Unilateral Pheochromocytoma Surgery.
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Ozan, Mahsum, Solmaz, İhsan, Kılıç, Jehat, Ay, Nurettin, Başçeken, Salim İlksen, Özçaylak, Süleyman, Acer, Firdevs, Bolayır, Başak, Soylu, Hikmet, Çetin, Sedat, and Diri, Halit
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PHEOCHROMOCYTOMA ,ADRENALECTOMY ,ETIOLOGY of diseases ,CALCITONIN ,CALCIUM - Abstract
Background: This case report provides detailed experiences of a patient with Multiple Endocrine Neoplasia type 2A (MEN-2A) who underwent surgery for pheochromocytoma and medullary thyroid cancer (MTC). Case Report: A 58-year-old male patient with resistant hypertension, despite triple anti-hypertensive drug therapy, was diagnosed with pheochromocytoma after investigation into the underlying etiology. Although the adrenalectomy performed was unilateral rather than bilateral, and there were no signs of Cushing's syndrome or adrenal insufficiency before the operation, temporary adrenal insufficiency developed after the excision of the large adrenal mass. Additionally, the biochemical diagnosis of MTC was primarily established using a calcium stimulation test (CST) rather than basal calcitonin levels. Conclusion: In cases where unilateral adrenalectomy is performed for a large adrenal mass, postoperative hypotension resistant to conservative therapy should raise suspicion of adrenal insufficiency. Furthermore, when basal calcitonin levels fall within the gray zone, a CST may be necessary for the diagnosis of MTC. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Retina ganglion cell/inner plexiform layer and peripapillary nerve fiber layer thickness in patients with acromegaly
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Şahin, Muhammed, Şahin, Alparslan, Kılınç, Faruk, Yüksel, Harun, Özkurt, Zeynep Gürsel, Türkcü, Fatih Mehmet, Pekkolay, Zafer, Soylu, Hikmet, and Çaça, İhsan
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- 2017
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8. Is there an association between thyroid function tests and 18F FDG PET/CT parameters in untreated cancer patients?
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KAPLAN, İhsan, primary, CAN, Canan, additional, KÖMEK, Halil, additional, KEPENEK, Ferat, additional, SOYLU, Hikmet, additional, ERDUR, Erkan, additional, AGÜLOĞLU, Nurşin, additional, and GÜNDOĞAN, Cihan, additional
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- 2022
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9. Identifying Clinical Characteristics of Hypoparathyroidism in Turkey: HIPOPARATURK-NET Study
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Konca Degertekin, Ceyla, primary, Gogas Yavuz, Dilek, additional, Pekkolay, Zafer, additional, Saygili, Emre, additional, Ugur, Kader, additional, Or Koca, Arzu, additional, Unubol, Mustafa, additional, Topaloglu, Omercan, additional, Aydogan, Berna Imge, additional, Ozdemir Kutbay, Nilufer, additional, Hekimsoy, Zeliha, additional, Yilmaz, Nusret, additional, Balci, Mustafa Kemal, additional, Tanrikulu, Seher, additional, Aydogan Unsal, Yasemin, additional, Ersoy, Canan, additional, Omma, Tulay, additional, Keskin, Muge, additional, Yalcin, Mehmet Muhittin, additional, Yetkin, Ilhan, additional, Soylu, Hikmet, additional, Karakose, Melia, additional, Yilmaz, Merve, additional, Karakilic, Ersen, additional, Piskinpasa, Hamide, additional, Batman, Adnan, additional, Akbaba, Gulhan, additional, Elbuken, Gulsah, additional, Tura Bahadir, Cigdem, additional, Kilinc, Faruk, additional, Bilginer, Muhammet Cuneyt, additional, Turhan Iyidir, Ozlem, additional, Canturk, Zeynep, additional, Aktas Yilmaz, Banu, additional, Sayiner, Zeynel Abidin, additional, and Eroglu, Mustafa, additional
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- 2021
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10. Evaluation of Cytopathological and Histopathological Compatibility in Thyroid Nodules: Single Center Study with 425 Cases
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Şeker, Nazlı Sena, primary, Kaya, Şeyhmus, additional, Şenol, Ayhan, additional, and Soylu, Hikmet, additional
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- 2021
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11. Evaluation Of Cytopathological And Histopathological Compatibility In Thyroid Nodules: Single Center Study With 425 Cases
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ŞEKER, Nazlı Sena, KAYA, Şeyhmus, ŞENOL, Ayhan, and SOYLU, Hikmet
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Thyroid nodule,Cytopathology,Fine needle aspiration ,Tiroid nodül,Sitopatoloji,İnce iğne aspirasyon ,Medicine ,Tıp - Abstract
Amaç: Tiroid nodülleri, toplumda sık görülen ve görüntüleme yöntemleri arttıkça insidantal saptanma oranları da gittikçe artan bir sağlık problemidir. Bu nedenle ki tiroid nodüllerine klinik yaklaşımda takip edilecek ve operasyona yönlendirilecek olguların ayrımı için, sitopatolojik Bethesda sınıflaması çok önemli bir yer tutmaktadır. Bu sınıflama sistemi 6 kategoriden oluşmaktadır ve tiroid nodüllerinin hepsini bir sınıflamaya koymak mümkündür. Biz çalışmamıza tiroid ince iğne aspirasyon sitoloji (İİAS) yapılan ve sonrasında cerrahi opere edilen olguları retrospektif olarak inceleyerek, kendi merkezimizdeki uyumu değerledirmeyi amaçladık. Materyal ve Metot: Çalışmamıza, S.B.Ü Diyarbakır Gazi Yaşargil Eğitim ve Araştırma Hastanesinde, 2014-2019 yılları arasında opera edilen ve öncesinde tiroid İİAB uygulanan 425 olgu dâhil ettik. Tiroid Bethesda sınıf 4 (Foliküler neoplazi/Foliküler neoplazi kuşkusu) olgularının histopatolojik tanıları ile papiller mikrokarsinom ve Hashimoto/lenfositik tiroidit tanısı alan vakaların sitopatolojik tanıları ayrıca belirtilmiştir. Bulgular: Bethesda tiroid sitopatoloji sınıflamasına göre, olguların 53’ü yetersiz, 193’ü benign, 85’i önemi belirsi atipi/önemi belirsiz foliküler lezyon, 22’si foliküler neoplazi açısından kuşkulu, 61’i malignite açısından kuşkulu ve 11’i malign sitoloji olarak raporlanmıştır. Histopatolojik olarak tiroid papiller mikrokarsinom tanısı alan toplam 33 olgunun çoğunluğu 10 (%31) önemi belirsiz atipi tanısı almış olup sırasıyla; yetersiz 7 (%21), benign 7 (%21), malignite açısından kuşkulu 7 1(%21), foliküler neoplazi kuşkusu 1 (%3) ve malign sitoloji 1 (%3) tanıları almıştır. Hashimoto tiroiditi ya da lenfositik tiroidit tanısı alan toplam 51 vakanın sitoloji preparatında aldığı tanılar sırasıyla; benign 17 (%33), önemi belirsiz atipi 16 (%51), malignite kuşkulu 11 (%21), yetersiz 4 (%8), foliküler neoplazi kuşkusu 2 (%4) ve malign sitoloji 1 (%2)’dir.Sonuç: Çalışmamızda, vaka oranlarımız genel olarak literatür ile uyumludur. Ancak papiller mikrokarsinomların yanlış negatif tanı oranını arttırabileceğini, Hashimoto tiroiditi/lenfositik tiroidit olgularının ise önemli belirsiz atipi ve malignite kuşkulu sitoloji tanılarını arttırabileceği gözlemlenmiştir. Tek merkezle yaptığımı çalışmamızda sitolojik tanı veririken olgunun bu yönlerden klinik, sonografik ve laboratuar bulgularıyla birlikte değerlendirilmesi gerektiğini böylece bu durumu aşabileceğimizi düşünmekteyiz., Aim: Thyroid nodules are a common health problem, which is common in the community, and its rates of detection are increasing in proportion to the increasing use of imaging methods. For this reason, cytopathological classification of Bethesda has a very important place for the differentiation of the cases that will be followed in the clinical approach to the thyroid nodules and directed to the operation. This classification system consists of 6 categories and it is possible to put all thyroid nodules into one classification. We aimed to evaluate the compliance in our center by retrospectively examining the patients who underwent thyroid fine needle aspiration cytology (FNAC) and subsequently operated surgically.Material and Method: In our study, we included 425 patients who were operated between 2014-2019 and who had undergone thyroid FNAC in the Diyarbakır Gazi Yaşargil Training and Research Hospital. Histopathological diagnoses of thyroid Bethesda class 4 (Follicular neoplasia / Follicular neoplasia suspicion) cases and cytopathological diagnoses of cases diagnosed with papillary microcarcinoma and Hashimoto / lymphocytic thyroiditis were also evaluated.Results: According to the Bethesda thyroid cytopathology classification, 53 of the cases were reported as nondiagnostic, 193 as benign, 85 as Atypia of Undetermined Significance or Follicular Lesion of Undetermined Significance (AUS / FLUS), 22 as suspicious in terms of follicular neoplasia, 61 as suspicious in terms of malignancy, and 11 as malignant cytology. 33 cases diagnosed with thyroid papillary microcarcinoma, cytopathologically; 10 (31%) were reported as AUS / FLUS, 7 (%21) were non-diagnostic, 7 (%21) were benign, 7 (%21) were Suspicious for Malignancy, 1 (%3) were Follicular Neoplasm or Suspicious for a Follicular Neoplasm, and 1 (%3) was reported as malignant cytology. The diagnoses of 51 cases diagnosed with Hashimoto thyroiditis or lymphocytic thyroiditis in the cytology preparation are; benign 17 (33%), AUS/FLUS 16 (51%), suspicious of malignancy 11 (21%), nondiagnostic 4 (8%), Follicular Neoplasm or Suspicious for a Follicular Neoplasm 2 (4%) and malignant cytology 1 (2%).Conclusion: In our study, our case rates are generally compatible with the literature. However, we observed that papillary microcarcinomas may increase the false negative diagnosis rate, while Hashimoto's thyroiditis /Lymphocytic thyroiditis cases may increase cases of AUS/FLUS and suspicious of malignancy cytology. In our study with a single center, we think that the case should be evaluated together with clinical, sonographic and laboratory findings in these aspects, and that we can overcome this situation.
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- 2020
12. Clinical characteristics of subjects with very high serum 25 OH vitamin D levels in turkey: DeVIT-TOX survey
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Pekkolay, Zafer, primary, Gogas, Yavuz Dilek, additional, Sedar, Saygili Emre, additional, Topaloğlu, Ömercan, additional, Emir, Önder Çağatay, additional, Soylu, Hikmet, additional, Taskaldiran, Isilay, additional, Esen, Pazır Ayșe, additional, Ugur, Kader, additional, Tanrikulu, Seher, additional, Nur, Firat Sevde, additional, Meryem, Atak Burcu, additional, Batman, Adnan, additional, Omma, Tülay, additional, Cagiltay, Eylem, additional, Ozdemir, Kutbay Nilufer, additional, Çetinkaya, Altuntaș Seher, additional, Nasiroglu, Imga Narin, additional, Karakilic, Ersen, additional, Hekimsoy, Zeliha, additional, Kılınç, Faruk, additional, Yay, Adnan, additional, Eroğlu, Mustafa, additional, and Kemal, Tuzcu Alpaslan, additional
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- 2020
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13. Tiroid Nodüllerinde Sitopatolojik ve Histopatolojik Uyum Değerlendirmesi: 425 Olgu İçeren Tek Merkez Çalışması.
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Şeker, Nazlı Sena, Kaya, Şeyhmus, Şenol, Ayhan, and Soylu, Hikmet
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THYROIDITIS ,AUTOIMMUNE thyroiditis ,THYROID cancer ,PAPILLARY carcinoma ,DIAGNOSIS ,TUMORS ,THYROID nodules ,NEEDLE biopsy - Abstract
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- 2021
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14. Iatrogenic Cushing’s syndrome with inhaled steroid plus antidepressant drugs
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Celik Ozlem, Niyazoglu Mutlu, Soylu Hikmet, and Kadioglu Pinar
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Cushing’s syndrome ,Fluticasone propionate ,Mirtazepine ,Paroxetine ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Current guidelines recommend the use of inhaled corticosteroids (ICS) for suppression of airway inflammation in patients with asthma. Although it is well known that ICS cause dose-related adrenocortical suppression, it is less known that they can lead to iatrogenic Cushing’s syndrome (CS). Fluticasone propionate (FP) is an ICS more potent than beclomethasone and budesonide. FP is metabolized as mediated by cytochrome P450 3A4 in the liver and the gut. Systemic bioactivity of FP can increase with the use of drugs that affect the cytochrome P450. Herein, we report the rapid development of iatrogenic CS in a patient receiving paroxetine and mirtazepine for 12 weeks in addition to inhaled FP.
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- 2012
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15. Pseudohypoparathyroidism Type 1A: Case report
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Güven, Mehmet, Pekkolay, Zafer, Soylu, Hikmet, Balsak, Belma Özlem Tural, Tuzcu, Alpaslan Kemal, Dicle Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Hastalıkları Bilim Dalı, and 0-Belirlenecek
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endocrine system ,Hypocalsemia ,endocrine system diseases ,Pseudohypoparathyroidism ,Hipokalsemi ,Psödohipoparatiroidi ,Albright’s hereditary osteodystrophy ,hormones, hormone substitutes, and hormone antagonists ,Albright herediter osteodistrofisi - Abstract
Psödohipoparatiroidizm (PHPT); hedef organın parathormona (PTH) yanıt vermediği kalıtımsal bir bozukluktur. Biyokimyasal olarak; hipokalsemi, hiperfosfatemi ve PTH yüksekliği ile karakterizedir. PTH uygulamasına verilen yanıt belirgin derecede düşüktür. Tip 1A, biyokimyasal özelliklere ek olarak Albright herediter osteodistrofisi (AHO) olarak bilinen karakteristik somatik bir fenotipe de sahiptir. Bu fenotipin, kısa boy, yuvarlak yüz, frontal bombelik, brakidaktili, obezite özelikleri bulunmaktadır. Burada biz, hipokalsemi ve Albright herediter osteodistrofisi tanısı koyduğumuz; kalsiyum, aktif D vitamini ile tedavi ettiğimiz olgumuzu sunduk. Pseudohypoparathyroidism (PHPT); is a hereditary disorder in which the target organ does not respond to parathormone (PTH). Biochemically; it is characterized by the hypocalcemia, hyperphosphatemia, and elevated PTH. The response to PTH administration is markedly lower. In addition to it's biochemical properties, Type 1A also has a characteristic somatic phenotype known as Albright hereditary osteodystrophy (AHO). This phenotype is characterized by short stature, round face, frontal bubble, brachydactyly, obesity. Here, we present a patient, diagnosed with Albright’s hereditary osteodystrophy and hypocalcemia that is treated by calcium, vitamin D .
- Published
- 2017
16. İNFERTİL BİR ERKEKTE 46XX TESTİKÜLER BOZUKLUK
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PEKKOLAY, Zafer, KILINÇ, Faruk, TUNA, Mazhar Müslüm, SOYLU, Hikmet, and TUZCU, Alpaslan Kemal
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Health Care Sciences and Services ,46 XX testiküler bozukluk,erkek infertilitesi,SRY,erkek infertilitesi ,Sağlık Bilimleri ve Hizmetleri ,46 XX testicular disorder,SRY,male infertility - Abstract
46 XX malesexual disorder is a very rare disease. SRY (sex-determining region Y) locatedin the Y chromosome is a main sex-specific gen location. It is thought that thetranslocation of Y chromosome part containing this gene region to the Xchromosome is responsible for the disorder. A 35 year-old male patient wasadmitted to the outpatient clinic with complaints of infertility and decreasedsexual desire. Physical examination revealed wrinkles on the face, lack ofhair, short stature as well as small testicles. Hypergonadotropic hypogonadismand azoospermia were detected in the patient. The patient's karyotype analysiswas reported as 46 XX. SRY gene analysis was positive. These patients do nothave spermatogenesis, thus sperm can not be obtained with testis biopsy. Themain treatment of the disease is testosterone replacement therapy. In thedifferential diagnosis of patients with primary hypogonadism presenting withinfertility, this rare disease should be considered., 46 XX erkekcinsel gelişim bozukluğu çok nadir görülen bir hastalıktır. Y kromozomunayerleşmiş olan SRY (sex-determining region Y) geni cinsiyet belirleyen gendir.Bu gen bölgesini içeren Y kromozomunun bir parçasının X kromozomuna translokeolmasıyla hastalığın geliştiği düşünülmektedir. Otuz beş yaşında erkek hastainfertilite, cinsel istekte azalma şikayetleriyle polikliniğimize başvurdu.Fizik muayenesinde yüzde kırışıklıklar, kıllanma azlığı, kısa boy, küçüktestisler mevcuttu. Hastada hipergonadotropik hipogonadizm ve azospermisaptandı. Hastanın karyotip analizi 46 XX olarak rapor edildi. SRY gen analizipozitif bulundu. Bu hastalarda spermatogenez olmadığından testis biyopsisi ilesperm elde edilemez. Hastalığın başlıca tedavisi testosteron yerine koymatedavisidir. İnfertilite ile başvuran primer hipogonadizmli hastaların ayırıcıtanısında bu nadir hastalık dikkatealınmalıdır.
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- 2016
17. Greft sağkalımını etkileyen faktörlerin transplant böbrek biyopsileriyle değerlendirilmesi
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Saygılı, Emre Sedar, primary, Seyahi, Nurhan, additional, Durak, Haydar, additional, Soylu, Hikmet, additional, Cengiz, Mahir, additional, and Altıparmak, Mehmet Rıza, additional
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- 2018
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18. Mild Symptomatic Postpartum Pituitary Apoplexy: A Case Report
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GÜVEN, Mehmet, primary, PEKKOLAY, Zafer, additional, TURAL BALSAK, Belma Özlem, additional, SOYLU, Hikmet, additional, and TUZCU, Alpaslan Kemal, additional
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- 2018
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19. Preoperative Parenteral İbandronate for Treating Severe Hypercalcemia Associated with Primary Hyperparathyroidism: An Effective and Cheap Drug
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PEKKOLAY, Zafer, primary, KILINÇ, Faruk, additional, SOYLU, Hikmet, additional, TURAL BALSAK, Belma Özlem, additional, GÜVEN, Mehmet, additional, ALTUN TUZCU, Şadiye, additional, and TUZCU, Alpaslan Kemal, additional
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- 2018
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20. İNFERTİL BİR ERKEKTE 46XX TESTİKÜLER BOZUKLUK
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pekkolay, zafer, primary, Kılınç, Faruk, additional, Tuna, Mazhar Müslüm, additional, Soylu, Hikmet, additional, and Tuzcu, Alpaslan Kemal, additional
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- 2017
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21. Thyrotoxicosis due to functioning metastatic follicular thyroid cancer
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TUZCU, Sadiye Altun, KİLİNC, Faruk, PEKKOLAY, Zafer, SOYLU, Hikmet, and TUZCU, Alpaslan Kemal
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endocrine system ,endocrine system diseases ,metastatic follicular thyroid cancer,thyrotoxicosis - Abstract
Thyrotoxicosis is a common condition associated with excess circulating thyroid hormones. Rarely, thyrotoxicosis can be developing due to functioning metastatic thyroid carcinoma. Most of patients with functional thyroid cancer metastases have had normal thyroxine (T4) concentrations but high serum triiodothyronine (T3-thyrotoxicosis). Inappropriately supressed TSH levels with normal T4 levels may be helpful to suspect T3 thyrotoxicosis. In this case report we present a case of thyrotoxicosis due to metastatic follicular thyroid cancer with a huge metastatic lesion.
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- 2016
22. Nonfonksiyonel adrenal insidentaloma insülin direnci ile ilişkili olabilir
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Barutçu, Sezgin, Tuna, Mazhar Müslüm, Kılınç, Faruk, Pekkolay, Zafer, Soylu, Hikmet, Tuzcu, Alpaslan Kemal, Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalı, Barutçu, Sezgin, Tuna, Mazhar Müslüm, Kılınç, Faruk, Pekkolay, Zafer, Soylu, Hikmet, and Tuzcu, Alpaslan Kemal
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İnsulin direnci ,Adrenal insidentaloma ,Homeostatic model assessment ,Insulin resistance ,Adrenal incidentaloma - Abstract
Amaç: Adrenal insidentalomalar; adrenal bezle ilişkili herhangi bir hastalık kuşkusu yokken görüntüleme yöntemleri veya abdominal laparotomide tesadüfen saptanan kitlelerdir. Abdominal görüntüleme yöntemlerinin kullanımının artması ile adrenal insidentalomaların tespit edilme sıklığı da artmıştır. Bu çalışmada nonfonksiyonel adrenal insidentalomalı (NFAI) hastaların demografik özellikleri ve insülin direncini araştırmayı amaçladık.Yöntemler: Çalışmaya 2007-2013 yılları arasında Dicle Üniversitesi Tıp Fakültesi Endokrinoloji Anabilim Dalı'nda NFAI nedeniyle takip edilen 30 hasta (20 kadın, 10 erkek) ve 66 sağlıklı birey (44 kadın, 22 erkek) dahil edildi. Hasta dosyalarından hastalara ait fizik muayene, ultrason, bilgisayarlı tomografi sonuçları kaydedildi. Tüm hastalara 1 mg deksametazon testi, idrar metanefrin ve normetanefrin, serum aldosteron ve renin düzeyi bakılmıştı. Açlık kan şekeri (AKŞ) ve insülin değerleri mevcut olan hastaların homeostatic model assessment- insulin resistance (HOMA-IR) formülüne göre insülin direnci hesaplandı, yaş ve beden kitle indeksi (BKİ) farklı olmayan kontrol grubundaki sağlıklı bireylerle karşılaştırıldı.Bulgular: Hastaların yaş ortalaması 45,9±10,9, BKİ 28,5±5,8 kg/m2 idi. Gruplar arasında yaş, cinsiyet ve BKİ açısından fark yoktu. AKŞ ve HOMA IR, NFAI grubunda kontrol grubuna göre anlamlı olarak yüksekti (sırasıyla, p= 0,022 ve p=0,005). LDL, HDL kolesterol ve trigliserid düzeyleri bakımında gruplar arasında farklılık gözlenmedi (p>0,05). Sonuç: Nonfonksiyonel adrenal insidentalomalı hastalar insulin direnci ve metabolik parametreler açısından riskli olduklarından bu açıdan değerlendirilmelidir. Objective: Adrenal incidentaloma are bulks which are stated incidentally by imagining methods or in abdominal laparotomy when there is no suspicion of any disease in adrenal gland. With increase in using abdominal ultrasonography and BT, the frequency of determining adrenal incidentaloma also increases. In this study, we aimed to examine demographical features and insulin resistance in patients with non functioning adrenal incidentaloma (NFAI). Methods: 30 (20 female-10 male) patients, who followed due to NFAI at Dicle University Medical Faculty Department of Endocrinology between years of 2007-2013, and age, BMI matched 66 healthy subjects were included in the study. Results of physical examination, USG and BT were recorded from patients' files. All patients were underwent following analyses for excluding a functioning adrenal mass, overnight dexamethasone suppression test, 24 hour urinary metanephrine and normetanephrine, plasma aldosterone/ renin activity ratio. Insulin resistance was calculated in accordance with homeostatic model assessmentinsulin resistance formula. Results: The average of age was 45.9 ± 10.9 years and body mass ındex (BMI) 28.5 ± 5.8. There were no significantly difference in terms of age, gender and BMI between groups. Fasting blood glucose and insulin resistance were significantly higher in patients with non-functional adrenal incidentaloma than control group (p=0.022, p=0.005i respectively). No significant difference was found between groups, in terms of LDL, HDL and triglyceride levels. Conclusion: patients with NFAI are more prone to have insulin resistance and hyperglycemia. Thus, clinicians should evaluate those patients with NFAI, in terms of metabolic parameters.
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- 2014
23. Clinical and Demographic Characteristics of 78 Patients with Adrenal Incidentaloma [Adrenal İnsidentalomalı 78 Hastanın Demografik ve Klinik Özellikleri]
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Kılınç, Faruk, Tuna, Mazhar Müslüm, Barutçu, Sezgin, Pekkolay, Zafer, Soylu, Hikmet, and Tuzcu, Alpaslan Kemal
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Adrenal incidentaloma,demographic characteristics,epidemiology - Abstract
Adrenal incidentalomas (AIs) are adrenal lesions detected on abdominal imaging procedures or abdominal laparotomy that had been performed for unrelated reasons. AIs have become a common clinical concern as a result of widespread use of abdominal ultrasound, CT and MR imaging in clinical practice. The aim of this study was to evaluate the demographical and clinical data our patients with AI. This study included data from 78 patients (53 female – 25 male) with AI those followed at Dicle University School of Medicine, Department of Endocrinology and Metabolism, between 2007 and 2013. Data collected from the records were physical and hormonal evaluation, diameter of the lesion, and the features of the lesion on radiological imaging. Also the results of serum cortisol, aldosterone, renin and 24 hour urinary metanephrine and normetanephrine were recorded. The average age of patients were 48.6 ±14.9 years. There was no significant difference in terms of localization of adenomas. Body mass ındex of patients were 28.54 ± 5.82. Of the patients, 45 (57.7%) were diagnosed as non-functional AI, 10 (12.8%) as subclinical Cushing’s syndrome, 11 (14,1%) as pheochromocytoma, 2(2.6%) as primary hyperaldosteronism, and 3(3.8%) as adrenal carcinoma. Ganglioneuroma was stated in 2 patients (2.6%), myelolipoma was stated in 1 patient (1.3%), adrenal adenoma was stated in 1 patient, adrenal cyst was stated in 1 patient, schwannoma was stated in 1 patient and neoplasia with small circular cells was stated in 1 patients. AIs are currently more frequently detected in clinical practice due to increased use of imaging techniques. Although the vast majority of AIs are benign and non-functioning, appropriate hormonal evaluation and imaging procedures must be performed. Keywords: Adrenal incidentaloma, demographic characteristics, epidemiology ÖzetAdrenal insidentalomalar (AI); adrenal bezde herhangi bir hastalık kuşkusu yokken görüntüleme yöntemleri veya abdominal laparotomide tesadüfen saptanan kitlelerdir. Abdominal ultrasonografi, BT ve MR kullanımının artması ile adrenal insidentalomaların tespit edilme sıklığı da artmıştır. Bu çalışmamızda, AI nedeniyle takip edilen hastalarmızın demografik ve klinik verilerini sunmayı amaçladık. Bu çalışmaya 2007-2013 yılları arasında Dicle Üniversitesi Tıp Fakültesi Endokrinoloji Anabilim Dalı’na başvuran 78 hasta ( 53 kadın; 25 erkek) dahil edildi. Hasta dosyalarından hastalara ait fizik muayene, USG, BT sonuçları kaydedildi. Serum kortizolü, idrar metanefrini, idrar normetanefrini, idrar VMA, serum aldosteronu ve serum renin değerleri kaydedildi. Hastaların yaş ortalaması 48.6 ± 14.9 idi. Tespit edilen kitlelerin lokalizasyonu açısından anlamlı farklılık saptanmadı. Hastaların vücut kitle indeksi 28.54 ± 5.82 idi. 45 hastada (% 57.7) non-fonksiyonel adenom, 10 hastada (% 12.8) subklinik cushing, 11 hastada (% 14.1) feokromasitoma, 3 hastada (% 3.8) adrenal karsinom, 2 hastada (% 2.6) hiperaldosteronizm, 2 hastada (% 2.6) ganglionörom, 1 hastada (% 1.3) myelolipom, 1 hastada adrenal adenom, 1 hastada adrenal kist, 1 hastada schwannom ve 1 hastada da küçük yuvarlak hücreli tümör tespit edildi. Radyolojik görüntüleme sıklığı arttıkça adrenal insidentaloma olgularının sayısı da artmaktadır. Her adrenal insidentaloma, malign olup olmadığı ve hormonal işlevi olup olmadığı açısından değerlendirimelidir. Keywords: Adrenal insidentalom, demografik özellikler, epidemiyoloji
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- 2015
24. Psödohipoparatiroidi Tip 1A: Olgu Sunumu
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Güven, Mehmet, primary, Pekkolay, Zafer, additional, Soylu, Hikmet, additional, Tural Balsak, Belma Özlem, additional, and Tuzcu, Alpaslan Kemal, additional
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- 2017
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25. TİROTOKSİKOZUN NADİR BİR NEDENİ: MOL HİDATİFORM
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pekkolay, zafer, primary, FINDIK, Fatih Mehmet, additional, SOYLU, Hikmet, additional, TURAL BALSAK, Belma Özlem, additional, and TUZCU, Alpaslan Kemal, additional
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- 2017
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26. The Experience from Ten Insulinoma Cases
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PEKKOLAY, Zafer, primary, KILIÇ, Faruk, additional, TUNA, Mazhar, additional, SOYLU, Hikmet, additional, and TUZCU, Alpaslan Kemal, additional
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- 2017
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27. 5-Alpha Reductase Deficiency: A Review of Five Cases Diagnosed with Ambiguous Genitalia
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PEKKOLAY, Zafer, primary, KILINÇ, Faruk, additional, ALTUN TUZCU, Şadiye, additional, SOYLU, Hikmet, additional, and TUZCU, Alpaslan Kemal, additional
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- 2017
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28. A rare cause of acromegaly: McCune-Albright syndrome
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BODAKÇİ, Erdal, TUNA, Mazhar, KILINÇ, Faruk, PEKKOLAY, Zafer, SOYLU, Hikmet, TUZCU, Şadiye, and TUZCU, Alpaslan
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musculoskeletal diseases ,McCune-Albright syndrome ,acromegaly ,fibrous dysplasia ,McCune-Albright sendromu,fibröz displazi,akromegali - Abstract
McCune-Albright syndrome is characterized by polyostatic fibrous dysplasia, brown spots on the skin (café au lait pigmentation) and autonomous endocrine hyperfunction. Early puberty and other endocrinological manifestations, such as acromegaly, gigantism and hypercortisolism are widely observed in the syndrome. Acromegaly is seen in 20% of patients. We report a case of acromegaly accompanied with this syndrome.Key words: McCune-Albright syndrome; acromegaly; fibrous dysplasia, McCune-Albright sendromu, poliostotik fibröz displazi, deride kahverenginde lekelenme (Cafe au lait lekeleri) ve otonomik endokrin hiperfonksiyon ile karakterize bir sendromdur. Bu sendromda yaygın olarak erken puberte ve diğer endokrinolojik manifestasyonlar örneğin akromegali, jigantizm, hiperkortizolizm görülebilir. Akromegali Mc-Cune-Albriht sendromlu hastaların % 20 sinde görülebilir. Biz bu sendroma eşlik eden bir akromegali vakasını sunduk
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- 2015
29. Alternative treatment of resistant hypoparathyroidism by intermittent infusion of teriparatide using an insulin pump: A case report.
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Pekkolay, Zafer, Kılınç, Faruk, Soylu, Hikmet, Balsak, Belma, Güven, Mehmet, Tuzcu, Şadiye Altun, Kara, Ali Veysel, and Tuzcu, Alpaslan Kemal
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Hypoparathyroidism usually responds to oral active vitamin D and calcium, but, although rare, some patients do not respond to this treatment. A 47-year-old Caucasian female presented to our medical unit with classical oral treatment-resistant hypocalcemia after thyroidectomy. Teriparatide was infused through the insulin pump with dosage set to 1 unit which equals to 2.5 μg of teriparatide. In conclusion, intermittent subcutaneous infusion of teriparatide using an insulin pump is a safe and effective treatment modality to ensure normocalcemic conditions in patients with classical treatment-resistant hypoparathyroidism. [ABSTRACT FROM AUTHOR]
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- 2019
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30. A Case Report of Allgrove Syndrome with Neurological Involvement
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PEKKOLAY, Zafer, KILINÇ, Faruk, TUNA, Mazhar Müslüm, SOYLU, Hikmet, ATEŞ, Kenan, TUZCU, Alpaslan Kemal, Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı, Pekkolay, Zafer, Kılınç, Faruk, Tuna, Mazhar Müslüm, Soylu, Hikmet, Ateş, Kenan, and Tuzcu, Alpaslan Kemal
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Pediatrics ,medicine.medical_specialty ,Allgrove Syndrome ,lcsh:Medicine ,Achalasia ,Disease ,Alacrima ,Cardiac dysfunction ,Allgrove ,Autosomal recessive trait ,otorhinolaryngologic diseases ,medicine ,lcsh:R5-920 ,Allgrove,neuropathy,adrenal failure ,business.industry ,lcsh:R ,medicine.disease ,Dysphagia ,Neuropathy ,Surgery ,Adrenal failure ,neuropathy ,adrenal failure ,medicine.symptom ,lcsh:Medicine (General) ,business ,Peripheral Motor Neuropathy - Abstract
Allgrove syndrome is a very rare seen disorder with an autosomal recessive trait. The three characteristics of disease are alacrima, achalasia and adrenal failure. Alacrimia is the first manifestation in most cases. Achalasia and adrenal failure are seen later. Neurological involvement is rare and usually occurs in older age. A woman 22 years old admitted to our hospital with adrenal failure crisis. She had alacrimia and used teardrop for many years. Achalasia was diagnosed after evaluation of her dysphagia. Thus, diagnosis of Allgrove syndrome was done. Autonomic cardiac dysfunction and peripheral motor neuropathy were detected. In conclusion, Allgrove syndrome is rare and has life threatening potential due to adrenal failure. Early diagnosis and appropriate treatment may improve life quality and expectancy. Patients with relevant symptoms should be evaluated for autonomic neuropathy. Keywords: Allgrove; neuropathy; adrenal failure
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- 2015
31. Retina ganglion cell/inner plexiform layer and peripapillary nerve fiber layer thickness in patients with acromegaly
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Şahin, Muhammed, primary, Şahin, Alparslan, additional, Kılınç, Faruk, additional, Yüksel, Harun, additional, Özkurt, Zeynep Gürsel, additional, Türkcü, Fatih Mehmet, additional, Pekkolay, Zafer, additional, Soylu, Hikmet, additional, and Çaça, İhsan, additional
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- 2016
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32. A case of mediastinitis accompanied with hyperosmolar nonketotic coma
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Tuna, Mazhar Muslum, primary, Kilinc, Faruk, additional, Pekkolay, Zafer, additional, Soylu, Hikmet, additional, and Tuzcu, Alpaslan Kemal, additional
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- 2016
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33. Evaluation of the metabolic characteristics of patients with Acromegaly
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Kılınç, Faruk, primary, Pekkolay, Zafer, additional, gözel, Nevzat, additional, Soylu, Hikmet, additional, Yılmaz, Ahmet, additional, yıldırım, Yaşar, additional, Şahpaz, Fatih, additional, and tuzcu, Alpaslan kemal, additional
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- 2016
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34. Ambulatory Blood Pressure Monitoring and Echocardiographic Findings in Renal Transplant Recipients
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Kendirlinan Demirkol, Ozlem, primary, Oruc, Meric, additional, Ikitimur, Baris, additional, Ozcan, Sevgi, additional, Gulcicek, Sibel, additional, Soylu, Hikmet, additional, Trabulus, Sinan, additional, Altiparmak, Mehmet Riza, additional, and Seyahi, Nurhan, additional
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- 2015
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35. Renal transplantasyon sonrası survi ve surviye etki eden faktörlerin incelenmesi
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Soylu, Hikmet, Seyahi, Nurhan, and İç Hastalıkları Ana Bilim Dalı
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Kidney transplantation ,Nefroloji ,Survival ,Nephrology - Abstract
Amaç: Bu çalışmada renal transplantasyon yapılmış, 18 yaşından büyük erişkinlerde böbrek nakli sonrası, hasta ve greft survilerinin değerlendirilmesi ve surviye etki eden faktörlerin ortaya çıkarılması amaçlanmıştır.Hastalar ve yöntem: İ.Ü. CTF Transplantasyon Ünitesi'nde Ocak 1990 ile Kasım 2010 tarihleri arasında böbrek nakli yapılan 494 hastanın arşiv kayıtları incelendi. 18 yaşından küçük veya dosyaları bulunamayan hastalar çalışmaya alınmadı. Hastaların nakil tarihi, doğum tarihi, cinsiyet, primer hastalığı, nakil öncesi yapılan RRT süresi ve türü, PRA düzeyi, HLA missmatch sayısı, verici türü, DM, HBV ve HCV durumu, alıcı boyu, kilosu ve VKİ, yaşı, verici cinsiyeti, verici kreatinin, kullandığı immunsupresif tedavisi, CMV proflaksisi, GGF, ilk 1 ay içinde gelişen AR, enfeksiyon, 1.ay, 3.ay, 1.yıl, 5.yıl ve son kontrolde kreatinin düzeyi, HT, DM, HPL durumu, proteinüri varlığı, greft kaybı varsa nedeni ve tarihi, hasta ölmüş ise nedeni ve tarihi dosyalarından elde edildi. Hasta ve greft sürvisi Kaplan-Meier yöntemiyle hesaplandı. Sürviye etkili olan faktörlerin çoklu değişkenli analizi cox regresyon analizi ile yapıldı.Bulgular: Hastalar genellikle orta yaşlı ve genç (ortalama yaş 32.3±10.1) erkeklerdi (%64). Nakiller yüksek (%82.6) oranda canlı vericilerden yapılmıştı. Kaplan-Meier yöntemine göre 1 ve 5 yıllık greft sürvisi; %94.6, %85, hasta sürvisi ise %98.5, %96.3'dü. Greft sürvisi üzerine 1.ay kreatinin, 1.yıl proteinüri, verici tipi, takrolimus kullanımı, mikofenolik asit türevi kullanımı ve nakil süreci anlamlı olarak etkili bulunmuştur. Bu etkili faktörler Cox regresyon analizinde değerlendirildiğinde takrolimus kullanımı, 1.ay kreatinin seviyesi ve nakil süreci anlamlılıklarını kaybetmiştir.Sonuç: Çalışmamızda CTF'deki renal transplantasyon sürvisini ortaya koyduk. Transplantasyon ile ilgili bu verilerin bilinmesi, özellikle canlı vericiden nakil yapılan hastalarda, hasta seçimi, canlı verici seçimi ve hasta bilgilendirilmesi için önemlidir. Objective: The purpose of this study is evaluation of patient and graft survival after renal transplantation in adult patients older than 18 years and determination of the possible factors which are affecting the survival.Patients and methods: Records of 494 transplant patients, grafted at Istanbul University Cerrahpasa Faculty of Medicine Renal Transplantation Unit between January 1990 and November 2010, were retrospectively analysed. Patients younger than 18 years and patients with missing data were excluded. Date of transplant, date of birth, gender, primary disease, duration and type of RRT applied pre-transplant period, panel reactive antibody (PRA) level, number of HLA missmatch, donor type, diabetes, HBV and HCV status, receiver height, weight and body mass index (BMI), age, donor gender, donor creatinine, used immunosuppressive therapy, CMV prophylaxis, GGF, AR occurring within the 1st month, infection, the level of creatinine at 1st and 3rd months, 1st year, 5th year period and the last visit, HT, DM, HPL status, presence of proteinuria, cause and date of graft loss, if the patient died, the cause and date was obtained from the patients' files. Kaplan-Meier method was utilized for the patient and geft survival analyses. Cox regression analysis were performed for multi-variable analysis of the factors which are affecting the survival.Results: The majority of patients were middle-aged and younger (mean age 32.3 ± 10.1) men (64%). About eighty two percent of the transplants were from living donors. One and five-year graft survival rates were 94.6%, 85%, respectively whereas for the same years overall survival rates were 98.5% and 96.3%, respectively. We demonstrated that 1st month creatinine level, 1st ar proteinüria, donor type, usage of tacrolimus, usage of micofenolic acid derivatives and date of transplant were associated with graft survival. We evaluated these factors by Cox regression analysis, Tacrolimus usage, 1st month creatinine level and date of transplantation lost their significance.Conclusion: In this study, we demonstrated the factors which are affecting kidney transplant survival. Knowledge of these data at pre and post transplantation period, especially for living donors is important for selection of patient, selection of living donor and ability to inform patient about transplantation. 47
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- 2011
36. A Case Report of Urticeria Due to Metformin Therapy
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PEKKOLAY, Zafer, primary, TUNA, Mazhar Müslüm, additional, KILINÇ, Faruk, additional, SOYLU, Hikmet, additional, TUZCU, Alpaslan Kemal, additional, and EYNEL, Eren, additional
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- 2015
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37. Clinical and Demographic Characteristics of 78 Patients with Adrenal Incidentaloma [Adrenal Insidentalomali 78 Hastanin Demografik ve Klinik Ozellikleri]
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Kilinc, Faruk, primary, Tuna, Mazhar, additional, Barutcu, Sezgin, additional, Pekkolay, Zafer, additional, Soylu, Hikmet, additional, and Tuzcu, Alpaslan, additional
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- 2015
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38. Non functioning adrenal incidentalomas may be associated with insulin resistance
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Tuna, Mazhar Müslüm, primary, Barutçu, Sezgin, additional, Kılınç, Faruk, additional, Pekkolay, Zafer, additional, Soylu, Hikmet, additional, and Tuzcu, Alpaslan, additional
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- 2014
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39. Recurrent Port Infection Due to Chryseobacterium Indologenes
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Islak Mutcali, Sibel, primary, Yemisen, Mucahit, additional, Soylu, Hikmet, additional, Balkan, Ilker Inanc, additional, Mete, Bilgul, additional, and Saltoglu, Nese, additional
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- 2013
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40. Ambulatory Blood Pressure Monitoring and Echocardiographic Findings in Renal Transplant Recipients.
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Kendirlinan Demirkol, Ozlem, Oruc, Meric, Ikitimur, Baris, Ozcan, Sevgi, Gulcicek, Sibel, Soylu, Hikmet, Trabulus, Sinan, Altiparmak, Mehmet Riza, and Seyahi, Nurhan
- Abstract
Hypertension is common in renal transplant recipients (RTRs). Ambulatory blood pressure (BP) monitoring (ABPM) is important in diagnosing hypertension and diurnal BP variation. The authors set out to compare office BP and ABPM measurements to determine diurnal pattern and to evaluate echocardiographic findings in RTRs. ABPM and office BP measurements were compared in 87 RTRs. Echocardiographic evaluation was performed for each patient. The correlations between office and 24-hour ABPM were 0.275 for mean systolic BP (P=.011) and 0.260 for mean diastolic BP (P=.017). Only 36.8% had concordant hypertension between office BP and ABPM, with a masked hypertension rate of 16.1% and white-coat effect rate of 24.1%. Circadian BP patterns showed a higher proportion of nondippers (67.8%). Left ventricular mass index was increased in 21.8% of all recipients. There was a significant but weak correlation between office BP and ABPM. [ABSTRACT FROM AUTHOR]
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- 2016
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41. Akromegali hastalarının metabolik özelliklerinin değerlendirilmesi.
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Kılınç, Faruk, Pekkolay, Zafer, Gözel, Nevzat, Soylu, Hikmet, Yılmaz, Ahmet, Yıldırım, Yaşar, Şahpaz, Fatih, and Tuzcu, Alpaslan Kemal
- Abstract
Copyright of Journal of Clinical & Experimental Investigations is the property of Modestum Publications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2015
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42. Postmenopozal Kadınlarda Kemik Mineral Dansitometri Değerleri ile Hematolojik Parametrelerin Karşılaştırılması.
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Güzel, Yunus, Uyar, Ali, Tuzcu, Şadiye Altun, Kaplan, İhsan, Ergül, Serhat, Serdar Yıldırım, Mehmet, Soylu, Hikmet, and Taşdemir, Bekir
- Abstract
Objective: We aimed to evaluate the relationship between hemogram values, neutrophil lymphocyte ratio, platelet lymphocyte ratio and bone mineral densitometry values in postmenopausal women and thus to determine which parameter is in a stronger relationship with bone mineral densitometry values. Method: In this study, bone mineral densitometry values, neutrophil lymphocyte ratio, platelet lymphocyte ratio and hematological parameters (white blood cell, red blood cell, hemoglobin, platelet, lymphocyte, monocyte, basophil, neutrophil, eosinophil) of 64 postmenopausal female patients aged 50-60, with a body mass index in the range of 25-30 were retrospectively reviewed. Clinical conditions that may affect bone mineral density or hemogram values (acute and chronic infections, oncological, rheumatological and hematological diseases, chronic liver and kidney diseases, hyperparathyroidism, hypothyroidism, hyperthyroidism, vitamin D deficiency, steroid use, and a history of trauma or blood transfusion in the last one year) were excluded from the study. Then, correlation analysis was performed between bone mineral densitometry values and hematological parameters. Results: In our study, a statistically significant negative correlation was found between platelet lymphocyte ratio and femoral neck bone mineral density, femoral neck Z-score and femoral neck T-score (p=0.004, r=-0.353; p=0.005, r=-0.344; p=0.004, r=-0.359, respectively). In addition, a statistically significant positive correlation was found between monocyte values and femoral neck bone mineral density, femoral neck Z-score and femoral neck T-score. (p=0.030, r=0.272; p=0.038, r=0.259; p=0.022, r=0.285, respectively). There was no relationship between neutrophil lymphocyte ratio and bone mineral densitometry parameters. Conclusion: High platelet lymphocyte ratio and low monocyte value can be simple markers that can be used to help predict changes in bone density ratio after menopause. [ABSTRACT FROM AUTHOR]
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- 2021
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43. Evaluation of the effect of red cell distribution width on the development of acute renal failure in patients with sepsis.
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Kara, Ali Veysel, Tanrikulu, Sema, Aydın, Emre, Aydın, Fatma, Soylu, Hikmet, Yıldırım, Yaşar, Yılmaz, Zülfükar, Kadiroğlu, Ali Kemal, and Yılmaz, Mehmet Emin
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- *
ERYTHROCYTES , *ACUTE kidney failure , *SEPSIS , *PATIENTS - Abstract
Objective: Acute kidney injury (AKI) is an important clinical entity that is known to increase mortality in patients with sepsis. Erythrocyte maturation and proliferation are inhibited by pro-inflammatory cytokines; these cytokines exert effects on red cell distribution width (RDW) well. Based on this knowledge; our aim in this study was to evaluate the impact of RDW on acute kidney injury in patients with sepsis. Methods: 120 patients diagnosed with sepsis and admitted to intesive care unit (ICU) and treated between 2009-2013 were retrospectively evaluated. Patients were divided into two groups as follows: group 1 (RDW≥16.8) and group 2 (RDW<16.8). Multiple logistic regression analysis was used to determine the association between RDW and AKI and mortality. Results: There was a statistically significant relationship between AKI and RDW (p<0.001, OR=11.52) but there were no statistically significant relationship between AKI and sex, age, serum lactate levels as well as SOFA score. Also, there were statistically significant relationship between mortality and RDW (p=0.044, OR=5), serum lactate levels (p=0.030) and SOFA score (p<0.001). RDW was found associated with both AKI and mortality. Conclusions: Results suggest that RDW is an important parameter for predicting development of AKI and mortality in ICU patients with sepsis. [ABSTRACT FROM AUTHOR]
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- 2017
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44. İnfertil bir erkekte 46 XX testiküler bozukluk
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Hikmet Soylu, Mazhar Müslüm Tuna, Alpaslan Kemal Tuzcu, Faruk Kılınç, Zafer Pekkolay, Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalı, Pekkolay, Zafer, Kılınç, Faruk, Tuna, Mazhar Müslüm, Soylu, Hikmet, and Tuzcu, Alpaslan Kemal
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Erkek infertilitesi ,Male infertility ,SRY ,46 XX testiküler bozukluk ,46 XX testicular disorder - Abstract
46 XX erkek cinsel gelişim bozukluğu çok nadir görülen bir hastalıktır. Y kromozomuna yerleşmiş olan SRY (sexdetermining region Y) geni cinsiyet belirleyen gendir. Bu gen bölgesini içeren Y kromozomunun bir parçasının X kromozomuna transloke olmasıyla hastalığın geliştiği düşünülmektedir. Otuz beş yaşında erkek hasta infertilite, cinsel istekte azalma şikayetleriyle polikliniğimize başvurdu. Fizik muayenesinde yüzde kırışıklıklar, kıllanma azlığı, kısa boy, küçük testisler mevcuttu. Hastada hipergonadotropik hipogonadizm ve azospermi saptandı. Hastanın karyotip analizi 46 XX olarak rapor edildi. SRY gen analizi pozitif bulundu. Bu hastalarda spermatogenez olmadığından testis biyopsisi ile sperm elde edilemez. Hastalığın başlıca tedavisi testosteron yerine koyma tedavisidir. İnfertilite ile başvuran primer hipogonadizmli hastaların ayırıcı tanısında bu nadir hastalık dikkate alınmalıdır. 46 XX male sexual disorder is a very rare disease. SRY (sexdetermining region Y) located in the Y chromosome is a main sex-specific gen location. It is thought that the translocation of Y chromosome part containing this gene region to the X chromosome is responsible for the disorder. A 35 year-old male patient was admitted to the outpatient clinic with complaints of infertility and decreased sexual desire. Physical examination revealed wrinkles on the face, lack of hair, short stature as well as small testicles. Hypergonadotropic hypogonadism and azoospermia were detected in the patient. The patient's karyotype analysis was reported as 46 XX. SRY gene analysis was positive. These patients do not have spermatogenesis, thus sperm can not be obtained with testis biopsy. The main treatment of the disease is testosterone replacement therapy. In the differential diagnosis of patients with primary hypogonadism presenting with infertility, this rare disease should be considered.
- Published
- 2017
45. Recurrent port infection due to chryseobacterium indologenes.
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Mutcali SI, Yemisen M, Soylu H, Balkan II, Mete B, and Saltoglu N
- Abstract
Infections due to Chryseobacterium indologenes (C. indologenes) are rare and generally associated with immunosupression and indwelling catheters. We report a recurrent port infection caused by C. indologenes. In the first bacteremia episode we did not remove the port and only applied antibiotherapy. However, the patient presented with bacteremia with the same bacteria and successfully treated with antibiotherapy and removal of the port.
- Published
- 2013
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