Naresh Kumar Hanchate, Samuel A. Malone, Andrea Messina, S. Rasika, Vincent Prevot, Filippo Casoni, Sonal Shruti, Sébastien G. Bouret, Gaetan Ternier, Philippe Ciofi, Sophie Croizier, Charlotte Vanacker, Sara Trova, Paolo Giacobini, Vanacker, C., Trova, S., Shruti, S., Casoni, F., Messina, A., Croizier, S., Malone, S., Ternier, G., Hanchate, N. K., Rasika, S., Bouret, S. G., Ciofi, P., Giacobini, P., Prevot, V., Lille Neurosciences & Cognition - U 1172 (LilNCog (ex-JPARC)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Lille, University of Lausanne (UNIL), Physiopathologie de la Plasticité Neuronale (Neurocentre Magendie - U1215 Inserm), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), Lille Neurosciences & Cognition - U 1172 (LilNCog), FHU 1,000 Days for Health [Lille], Center for Integrative Genomics - Institute of Bioinformatics, Génopode (CIG), Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Lausanne = University of Lausanne (UNIL)-Université de Lausanne = University of Lausanne (UNIL), Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), ANR-14-CE12-0015,RoSes and GnRH,La signalisation cellulaire par les sémaphorines dans le contrôle neuroendocrinien de la reproduction(2014), ANR-17-CE16-0015,GRAND,Vieillissement et démence: un rôle hormonal?(2017), Université de Lausanne = University of Lausanne (UNIL), Bouret, Sebastien, Université de Lausanne (UNIL)-Université de Lausanne (UNIL), Prevot, Vincent, Appel à projets générique - La signalisation cellulaire par les sémaphorines dans le contrôle neuroendocrinien de la reproduction - - RoSes and GnRH2014 - ANR-14-CE12-0015 - Appel à projets générique - VALID, and Vieillissement et démence: un rôle hormonal? - - GRAND2017 - ANR-17-CE16-0015 - AAPG2017 - VALID
International audience; Hypothalamic neurons expressing gonadotropin-releasing hormone (GnRH), the "master molecule" regulating reproduction and fertility, migrate from their birthplace in the nose to their destination using a system of guidance cues, which include the semaphorins and their receptors, the neuropilins and plexins, among others. Here, we show that selectively deleting neuropilin-1 in new GnRH neurons enhances their survival and migration, resulting in excess neurons in the hypothalamus and in their unusual accumulation in the accessory olfactory bulb, as well as an acceleration of mature patterns of activity. In female mice, these alterations result in early prepubertal weight gain, premature attraction to male odors, and precocious puberty. Our findings suggest that rather than being influenced by peripheral energy state, GnRH neurons themselves, through neuropilin-semaphorin signaling, might engineer the timing of puberty by regulating peripheral adiposity and behavioral switches, thus acting as a bridge between the reproductive and metabolic axes.