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The development of the MCH system
- Source :
- Peptides, Peptides, Elsevier, 2009, 30 (11), pp.1969-72. ⟨10.1016/j.peptides.2009.07.016⟩
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- International audience; Although a great deal is published on the MCH neurons, very few works were devoted to the study of their development. However, existing literature points out two important traits: first, these neurons differentiate a MCH phenotype very early in all species studied so far, which might suggest a role for the MCH peptide during development; second, in the rat, birth date greatly influence the phenotype of MCH neurons. At least two sub-populations were described on the basis of their chemical phenotype, projection pattern and birth date. The understanding of processes involved in the differentiation of these sub-populations may help understand the medio-lateral differentiation of the tuberal hypothalamus.
- Subjects :
- MESH: Cell Differentiation
Melanin-concentrating hormone
Physiology
Cellular differentiation
Central nervous system
MESH: Neurons
Biology
Biochemistry
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
MESH: Melanins
Hypothalamic Hormones
medicine
Animals
Humans
MESH: Animals
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
030304 developmental biology
Melanins
Neurons
0303 health sciences
MESH: Humans
Neurogenesis
Cell Differentiation
respiratory system
Phenotype
MESH: Hypothalamic Hormones
Pituitary Hormones
medicine.anatomical_structure
MESH: Pituitary Hormones
chemistry
Hypothalamus
Birth date
Neuroscience
hormones, hormone substitutes, and hormone antagonists
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 01969781
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Peptides
- Accession number :
- edsair.doi.dedup.....aafd955d0254cd795f2bc09d7b072e6b