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Background: Vitamin D is thought to play a role in the pathogenesis of acne, and its levels can change in patients with acne vulgaris. Several studies have revealed that serum 25-hydroxy vitamin D levels tend to be low and statistically significant in acne vulgaris patients. However, the relationship between vitamin D levels and acne severity is still poorly understood. Objective: This study aims to identify the correlation between serum 25-hydroxy vitamin D levels and the severity of acne vulgaris. Method: This systematic review study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline based on several studies taken from the PubMed, PMC, Semantic Scholar, and ResearchGate databases until June 2021. Full-text case-control, randomized controlled trial, or cross-sectional study in English or Indonesian language reporting on the serum 25-hydroxy vitamin D levels and the severity of acne vulgaris on human participants were included. Result: From a total of 401 studies, 10 studies met the criteria. Almost all studies (8 of 10) revealed lower serum 25-hydroxy vitamin D levels as the acne severity progresses, although 2 of them were not statistically significant. Conclusion: The evidence of an inverse correlation between serum 25-hydroxy vitamin D levels and the severity of acne vulgaris suggests the need for screening of vitamin D levels in acne patients and offers a new prospect in the field of acne prevention and treatment.

BackgroundIn March 2012, the Xpert MTB/RIF assay (Xpert) was introduced in three provincial public hospitals in Indonesia as a novel diagnostic to detect tuberculosis and rifampicin resistance among high risk individuals.ObjectiveThis study assessed the effects of using Xpert in place of conventional solid and liquid culture and drug-susceptibility testing on case detection rates, treatment initiation rates, and health system delays among drug-resistant tuberculosis (TB) patients.MethodsCohort data on registration, test results and treatment initiation were collected from routine presumptive patient registers one year before and one year after Xpert was introduced. Proportions of case detection and treatment initiation were compared using the Pearson Chi square test and median time delays using the Mood's Median test.ResultsA total of 975 individuals at risk of drug-resistant TB were registered in the pre-intervention year and 1,442 in the post-intervention year. After Xpert introduction, TB positivity rate increased by 15%, while rifampicin resistance rate reduced by 23% among TB positive cases and by 9% among all tested. Second-line TB treatment initiation rate among rifampicin resistant patients increased by 19%. Time from client registration to diagnosis was reduced by 74 days to a median of a single day (IQR 0-4) and time from diagnosis to treatment start was reduced by 27 days to a median of 15 days (IQR 7-51). All findings were significant with pConclusionCompared to solid and liquid culture and drug-susceptibility testing, Xpert detected more TB and less rifampicin resistance, increased second-line treatment initiation rates and shortened time to diagnosis and treatment. This test holds promise to improve rapid case finding and management of drug-resistant TB patients in Indonesia.

Abstract Background Recent evidence suggests an elevated risk of cognitive impairment and dementia in individuals with atrial fibrillation (AF), irrespective of stroke occurrence. AF, known to reduce brain perfusion, particularly through silent cerebral ischemia, underscores the intricate relationship between cardiac and cerebral health. The heart plays a crucial role in supporting normal brain function, and rhythm control, a standard AF treatment, has demonstrated enhancements in brain perfusion. This systematic review aimed to examine published data concerning the influence of rhythm control on brain perfusion in patients with atrial fibrillation. Methods A systematic search for relevant studies was carried out in Scopus, PubMed, Cochrane Reviews, ProQuest, and EBSCOhost, spanning from their inception until April 30, 2023. Studies that specifically examined brain perfusion following any form of rhythm control in atrial fibrillation were included in the review. Results The review encompassed 10 studies involving 436 participants. Among these, six utilized electrical cardioversion for rhythm control. The majority (8 out of 10) demonstrated that restoring sinus rhythm markedly enhances brain perfusion. In one of the two remaining studies, notable improvement was observed specifically in a region closely linked to cognition. Additionally, both studies reporting data on the Mini‐Mental State Examination (MMSE) showed a consistent and significant increase in scores following rhythm control. Conclusion Successful rhythm control in AF emerges as a significant contributor to enhanced brain perfusion, suggesting a potential therapeutic avenue for reducing cognitive impairment incidence. However, further validation through larger prospective studies and randomized trials is warranted.

PT XYZ applies the Scrum framework to meet application’s user demands quickly. The average percentage of IT employee turnover that occurred at PT XYZ from 2020 to 2022 was 14.5%. Every time a company recruits a new employee, the company must help that employee to adapt the Scrum method used for the company's system development process. However, PT XYZ information technology division does not yet have a specific onboarding method to help new employees adapt to the implementation of Scrum effectively without disrupting the ongoing sprint. Qualitative methods are used in the case study to collect data from a hybrid working Scrum team through interviews. The interview data was analyzed thematically with a determined model from an existing onboarding theory. Onboarding practices and adjustments are described and delivered consisting of onboarding activities, newcomer adjustments, and workplace adjustments. A combination of general and specific onboarding practices related to agile helps the successful onboarding of new members to a Scrum team. A practical guide is also described to improve successful onboarding practices into Scrum teams.

This study aims to determine the effect of internal audits on fraud prevention. The formulations in this study are has the internal audit at the Selaawi Garut Unit Bank (BRI) adequately, does internal audit affect the prevention of fraud in the bank (BRI) Selaawi Garut Unit. The research method in this study is to use quantitative methods. The object of research is internal audit and fraud prevention. The dependent variable is Fraud Prevention, while the independent variable is Internal Audit. The research population is all employees who work at Bank BRI Unit Selaawi Garut, as many as 31 people. Samples were taken randomly from as many as 31 people. Data analysis used simple linear regression. The results showed that Internal Audit affected Fraud Prevention. Furthermore, the internal audit department personnel must enhance the caliber of their analytical procedures in the context of fraud auditing, preliminary surveys, program audits, and auditor team selection. This finding will enable future researchers to replicate the study by incorporating additional variables.

In the current era of 4.0 technology, there are many quadcopter applications for testing and usability in life) to monitor the surrounding environment while operating and navigate through the GCS depending on the purpose made. Therefore, the operation of the drone is controlled directly by the operator through certain communication networks such as remote control or automatically through devices that have been previously programmed. This is necessary in order to make it easier to move the drone and monitoring can be done through operator directions or image processing. Image Processing in the form of a QR Code that can provide directions to the drone so that navigation can run smoothly. Research using how the camera detects QR Code will give directions to the drone to navigate to make movements following the QR Code directions in a sequence of numbers so that the final result in the form of video can be viewed via GCS and camera via IP CAM. The results of this study indicate that the drone can detect QR Code and opencv also successfully translates pixels is a distance of 5 meters and navigating based on pixel size with more than 100 pixels, the drone can move automatically to a certain destination. With a distance of 1 meter, it produces 100 pixels on the x-axis and 108 pixels on the y-axis, while for the furthest distance from the QR Code, which is 5 meters, it produces 50 pixels on the x-axis and 80 pixels on the y-axis.

This study aims to find out how the perceptions of master students at the State Islamic University of North Sumatra in terms of knowledge and experience in utilizing the Cambridge journal database. The research method used was qualitative with the informant selection technique using snowball sampling and five informants were obtained who knew and had accessed the Cambridge database. Data collection techniques used observation, interviews, and documentation. The research results showed that the majority of informants did not know that the UINSU Library had subscribed to the Cambridge journal database service. Most students know about the database of Cambridge journals obtained from outsiders when they were undergraduate students so that it has an impact on usage statistics with 104 downloads per year. This is caused by promotions related to journal services that are not carried out evenly throughout the academic community due to the difference in location between the library and the postgraduate campus. There are several factors inhibiting students from not using the Cambridge journal database such as access to closed articles which causes students not to use the campus network to open access automatically or not to use accounts and passwords provided to log in outside the campus network.

AbstractVaccine acceptance is a critical issue to study because it provides a means of measuring a nation’s success in handling the COVID-19 pandemic, particularly in nations where vaccine hesitancy has historically been common. This article seeks to explore the non-medical reasons for public acceptance of vaccines. More specifically, it asks: why has Indonesia, a Muslim-majority nation with elevated levels of resistance to the government’s COVID-19 mitigation policies, ultimately implemented vaccine mandates? This article relies on qualitative research, using a case study as well as in-depth interviews with one hundred randomly selected respondents. It shows that public acceptance was driven not by health considerations, but by coercive regulations. Three factors drove public acceptance: proof of vaccination was legally required to access public facilities; proof of vaccination was legally required to access public transportation systems; and proof of vaccination was legally required to access government assistance. Facing such regulations, the public had no choice but to comply with vaccine mandates, as only then could they access public facilities, travel, and access government assistance. This study concludes that coercive vaccination policies, though repressive, have been effective means of ensuring public compliance and reducing the spread of COVID-19. This study provides the government with considerations for formulating more effective policies for pandemic mitigation.

Objectives: To determine the effectiveness of Diazepam in comparison with Phenobarbital. Methods: Twenty-seven male Swiss Webster mice were used and randomly divided into three groups of negative control (NS), positive control (Phenobarbital), and diazepam group. Two tests were performed on these group: the traction Test and the Fireplace Test. Pupillary diameter was also observed. Results: A significant difference based on the Kruskal - Wallis statistical test was observed between the positive control and the diazepam group (0.05). Conclusion: Diazepam has a better sedative effect than Phenobarbital. The sedative effect produced by Diazepam is stronger, with faster onset and longer half-life than the Phenobarbital the positive control. However, different test methods and comparisons should be sought to support this conclusion.

ERP is a useful application for companies to run day-to-day operations by automating business processes, but the complexity and difficulty of deploying ERP systems causes unanticipated implementation failures. Around 70% of ERP implementation fails to produce expected benefits, and three quarters of these projects fail. This study aims to uncover potential reasons that cause the failure of ERP system adoption using Company XYZ, a mining company as the case. A questionnaire was distributed to its management and employees. TOPSIS approach was used to rank the variables according to their significance in affecting failure of ERP systems implementation. The findings revealed that the two most important critical failure causes for ERP implementation are bad understanding of organization’s business processes and poor business process reengineering. The company needs to conduct a deeper analysis of the existing business processes in the business unit to be able to determine more appropriate business process reengineering for ERP implementation in the future. Companies and academics can utilize the study's findings as a helpful resource to identify the cause of ERP implementations failure

Kulit merupakan bagian pelindung terluar yang melapisi sebagian besar dari tubuh manusia. Kulit wajah menjadi bagian kulit paling sensitif sehingga lebih mudah bermasalah dibanding yang lainnya. Perawatan kulit wajah yang tidak tepat dapat menyebabkan timbulnya permasalahan kulit wajah yang baru atau bahkan memperburuk permasalahan sebelumnya. Mendeteksi tipe kulit menjadi langkah awal dalam pengobatan maupun perawatan. Selama ini, penentuan tipe kulit wajah harus dengan keterampilan dokter atau tenaga kesehatan dengan dibantu alat yang mahal dan sulit dimiliki, tetapi dengan adanya perkembangan teknologi saat ini memudahkan seseorang untuk menentukan tipe kulit wajah dengan lebih praktis dan mudah tanpa harus ke dokter. Dari beberapa penelitian yang telah dilakukan sebelumnya, tipe kulit wajah maupun penyakit yang timbul pada area wajah dapat dideteksi melalui pembelajaran citra dengan berbagai macam metode. Data citra yang digunakan sebagai pembelajaran berupa citra digital maupun citra mikroskopis yang kemudian diolah dengan berbagai metode ekstraksi ciri hingga diteruskan dengan klasifikasi tipe kulit. Proses tinjauan literatur menggunakan metode scoping review yang mengidentifikasi setiap literatur secara mendalam. Literatur yang digunakan disesuaikan dengan kriteria yang telah ditentukan seperti topik pembahasan, ketersediaan literatur full text, dan abstrak. Tinjauan literatur ini menunjukkan bahwa akurasi pengolahan citra tidak hanya ditentukan berdasarkan metode, melainkan terdapat faktor lain seperti jumlah dan kualitas dataset yang digunakan serta ekstraksi ciri yang dilakukan. Hasil dari tinjauan literatur ini memberikan gambaran mengenai studi yang relevan dengan topik, perbedaan setiap literatur yang dibahas serta bermanfaat bagi peneliti yang akan mengembangkan teknologi pengolahan citra untuk menentukan tipe kulit wajah. Abstract Skin is the outer protective part that covers most of the human body. Facial skin is the most sensitive part of the skin hence it is more prone to problems than other parts. Improper facial skin care can cause new facial skin problems or even aggravate the previous problems. Detecting on the skin type is the first step in treatment or care. So far, determining the type of facial skin must be with the skills of a doctor or health worker with the help of tools that are expensive and difficult to have, but with current technological developments it makes it easier for someone to determine the type of facial skin more practically and easily without having to see a doctor. From the several previous studies, facial skin types and diseases that emerge in the facial area can be detected through image learning using various methods. Image data used as learning is in the form of digital images and microscopic images which are then processed using various feature extraction methods and then continued with skin type classification. The literature review process uses the scoping review method which identifies each literature in depth. The literature used is adjusted to predetermined the criteria such as the topic of discussion, the availability of full text literature, and the abstraction. This literature review shows that the accuracy of image processing is not only determined based on the method, but there are also other factors such as the number and quality of the datasets used and the feature extraction performed. The results of this literature review provide an overview of studies that are relevant to the topic, the differences in each literature discussed and are useful for researchers who will develop image processing technology to determine the type of facial skin.

Di era digital seperti sekarang ini memiliki kartu kredit merupakan suatu hal yang wajar di masyarakat, dengan segala kemudahan yang ditawarkan dalam setiap transaksi pembayaran tidak menutup kemungkinan untuk menarik minat masyarakat dalam menggunakan kartu kredit. Dengan minat masyarakat yang tinggi terhadap kartu kredit, hal ini dapat dijadikan sebagai indikator yang baik bagi perusahaan kartu kredit untuk mengembangkan bisnis kartu kredit. Dalam rangka memenuhi kebutuhan konsumen akan kartu kredit, perusahaan dituntut untuk mengambil keputusan dalam menentukan strategi pemasaran yang tepat sehingga dapat menarik minat para pelanggan, salah satu caranya adalah dengan melakukan segmentasi pelanggan dengan metode clustering. Bisecting K-Means dan Fuzzy C-Means merupakan algoritma clustering yang akan digunakan pada penelitian ini untuk melakukan pengelompokan data pengguna kartu kredit. Analisis akan dilakukan untuk mengetahui algoritma dengan performa terbaik berdasarkan pengujian validitas dari kedua algoritma dengan menggunakan metode silhouette coefficient. Dari penelitian ini didapapatkan hasil bahwa Bisecting K-Means tanpa normalisasi memiliki nilai silhouette coefficient yang lebih tinggi dibandingkan dengan Fuzzy C-Means. Dimana nilai silhouette coefficient Bisecting K-Means sebesar 0.588 dan 0.579 dengan normalisasi, sedangkan nilai silhouette coefficient Fuzzy C-Means adalah 0.488 dan 0.582 dengan normalisasi.

This study aims to determine the performance of drip irrigation technology as compared to conventional farmer’s practice on rice growth and yield, grain quality, and water consumption. The research was carried out at the Sukamandi Experimental Station, Subang, West Java in July - October 2019. The test was arranged by a nested randomized block design with 5 replications. The main plot was water management with 2 levels: (1) Drip Irrigation Technology (DIT) and (2) Conventional Farmer’s Practice (CFP) (flooded condition) as a comparation. Subplot was varieties with 4 levels: two hybrid rice (1) Hipa 8 and (2) Hipa 18, upland rice (3) Inpago 11, and irrigated inbred rice (4) Inpari 42. The result showed that yield of DIT not significantly different to CFP with higher number of tillers per m2. However, it was lower for plant height, tillering ability, grain filling, 1000 grains weight, transpiration rate, assimilation rate and stomatal conductance. For grain quality determination, DIT gave an increase in the average of grain density and impurities, but decreased in the average percentage of chalky and immature grains. In Hipa 18, DIT was able to produce a higher percentage of head rice. DIT only consumed 3864 m3/ha/season water irrigation compared with average water consumption in Sukamandi Field Station which range of 7460-8740 m3/ha/season.

This study aimed to analyze the effect of Contextual Teaching and Learning (CTL) model assisted by booklets on the students’ creative thinking ability at grade IV elementary school. The choice of booklet media CTL model was considered appropriate for SDA and poetry materials on the theme of Cita-Citaku. Students could relate the materials to their life environment through CTL model and booklet media; this can be done in groups or individually. This study was quantitative experimental research with nonequivalent posttest-only control group design. The samples in this study were fourth grade students of SDN 1 Bulungcangkring as the experimental class and fourth grade students of SDN 3 Bulungcangkring as the control class. Based on the results of the study, it was revealed that (1) the thinking ability of students taught with CTL model assisted by booklet was better than those taught by the lecture model; (2) the average creative thinking ability of students taught with the CTL learning model was more than 70 (KKM). It could be concluded that there was an effect of Contextual Teaching and Learning model assisted by booklets on the students’ creative thinking abilities at grade IV elementary school.

People's interest in using the Mamminasata Bus Rapid Transit (BRT) has decreased significantly. This problem has an impact on the decline in Perum Damri's income. The purpose of this study is to determine the service quality of Mamminasata Bus Rapid Transit in Makassar so that it can increase public interest in using this mode of public transportation. Results show that the maximum gap in this study is -1.49, which means there is a gap between respondents' perceptions and expectations regarding the operational hours of Mamminasata Bus Rapid Transit. Most respondents, as many as 64 people (68.1%), said they did not know the BRT operational hours and the bus often come late to the bus stop. Respondents’ expectation that the BRT operational hours (arrival and departure) would be timely and clear. The smaller the gap (gap close to zero or positive) the better the service quality of the company. Conversely, the larger the gap, the lower the service quality of a company. Thus, service companies such as Perum Damri which is a provider of the Mamminasata Bus Rapid Transit in Makassar need to prioritize in improving service quality based on the results of the largest gap

This study aims to determine the effectiveness of mathematics learning achievement for students who are subjected to the Student Teams Achievement Divisions (STAD) model assisted by Interactive CD, Learning CD and Conventional learning models on flat-shaped materials in grade VII semester II students of SMP Negeri 223 Jakarta. The population in this study were students of class VII SMP Negeri 223 Jakarta. By using cluster random sampling technique selected VII 3 as the control class, VII 7 and VII 8 respectively as the experimental class STAD model assisted by learning CD and STAD model assisted by Interactive CD. The results showed that there was a significant difference between mathematics learning achievement students who are taught by learning using the STAD learning model assisted by Interactive CD, STAD learning model assisted by CD Learning and conventional learning, the learning achievement of students who receive learning using Interactive CD media is better than conventional learning. Likewise, the learning outcomes of students who receive learning using Learning CD media are better than conventional learning. In addition, there is no significant difference between the mathematics learning outcomes of students who are taught using the STAD learning model assisted by Interactive CD and students who use the STAD learning model assisted by the Learning CD.

Work environment conditions with high temperatures cause workers to experience fluid loss which can cause urine production to decrease so that the urine produced becomes concentrated. If this condition is left for a long time, it can cause saturation of the urine. This study used a cross-sectional design and had 32 respondents as tofu factory workers in Tandang Village, Semarang. The variable most related A working environment with high temperatures impacts the employees to encounter fluid loss which leads to the reduction of urine production, thus the urine production becomes concentrated. If this condition lasts for a long time, there will be saturation of the urine. This present study used a cross-sectional design with 32 employees of the tofu factory as the respondent in Tandang Village, Semarang. The most related variable with urine crystallization is water drinking consumption which is the most influential variable in the occurrence of urine crystallization. Employees who consume water drinking insufficient amounts have a probability crystallization of 41.80% compared to employees who consume less water drinking, namely the probability of urine crystallization of 98.81. From this equation, it can be interpreted that employees have a risk of urine crystallization of 0.4230 times. From the eight variables studied, there are four variables (age, water drinking consumption, heat density, and the level of dehydration) that had a statistically significant relationship with urine crystallization. Meanwhile, the most dominant variable based on the logistic regression test is air consumption. to urine crystallization is drinking water consumption which is the most influential variable in the implementation of urine crystallization. Workers who consume enough drinking water have a probability of urine crystallization of 41.80% comA working environment with high temperatures impact on the employees to encounter with the fluid loss which lead to the reduction of urine production, thus the urine production becomes concentrated. If this condition is not taken into account for a long period, it caused the saturation of urine. This present study used a cross-sectional design with 32 employees of the tofu factory as the respondent in Tandang Village, Semarang. The most related variable with urine crystallization is water drinking consumption which is the most influential variable in the occurrence of urine crystallization. Employees who consume water drinking insufficient amounts have a probability crystallization of 41.80% compared to employees who consume less water drinking, namely the probability of urine crystallization of 98.81. From this equation, it can be interpreted that employees have a risk of urine crystallization of 0.4230 times. From the eight variables studied, there are four variables (age, water drinking consumption, heat density, and the level of dehydration) that had a statistically significant relationship with urine crystallization. Meanwhile, the most dominant variable based on the logistic regression test is air consumption paired to workers who consume less drinking water, namely the probability of urine crystallization of 98.81. From this equation, it can be interpreted that workers have a risk of urine crystallization of 0.4230 times. Of the eight types of variables studied, empathy variables (age, air consumption, heat pressure, and degree of dehydration) had a statistically significant relationship with urine crystallization. Meanwhile, the most dominant variable based on the logistic regression test is air consumption.

Comics are illustrated stories that have been an alternative entertainment for many people of all ages. They can be fictional stories such as myths, legends, fairy tales, science fiction, and folklore. There are two types of comics: printed comics and digital comics. Many comics are translated from the source language to the target language. The translation process should ensure that the target text language is parallel with the source text language. Occasionally there are inaccurate translations, and the original message that the author wants to convey to the reader cannot be delivered. Due to the multimodality of comics, their translation often involves more complex processes compared to that of other text types. This literature review aimed to identify what problems exist in comics translation and what solutions had been suggested to overcome the problems. The primary goals were to synthesize the existing literature describing patterns of problems and strategies in translating comics. The data was collected from thirty research reports on the translation of comics in which the source language was either English or Indonesian. The review found five categories of problems with the two most frequent strategies suggested to overcome the problems.

The purpose of the research is to develop a project-based independent learning model in Vocational Fashion Technology. The research and development method uses 10 steps from Borg and Gall. The results of the development Project Based Independent Learning (PBIL) models are accompanied by PBIL learning manuals for educators. The steps of implementing the PBIL model, namely determining the fundamental questions, compiling project planning, preparing a schedule, monitoring students and project progress, analyzing project results and evaluating experience. Learning activities consist of face-to-face, independent learning by Android-based learning media and monitoring by social media. Effectiveness test results indicate , learning by PBIL models, students easier to learn lessons (97%); students helped in solving problems (91%); increase students’ courage to share opinions (85%); support students to work in a team(94%); motivate students to reach achievement (97%); students able to solve post test questions easier than before (97%); motivating students to complete tasks (97%); learning by PBIL model, students is closer to their teacher (97%).

The purpose of this study is to develop iSpring software aided interactive learning against student retention on the concept of calculus II. This type of research is RnD research. The development procedure, will be divided into 4 parts, namely preliminary analysis, implementation and preparation of learning media, validation and revision, and small-scale trials (limited). The sampling technique that I use is to use simple random sampling. The results show that there is a positive influence, student retention on student learning achievement in learning calculus II.

Public Speaking used to be called rhetoric to become one of the disciplines of public communication. With the development of such public speaking as a public communication skills that helped shape success. Women Community Owners of Small and Medium Enterprises in Rarang village, Terara sub-district, East Lombok Regency are a group of women to develop individual potential. The output is increased knowledge, skills and skills in communication at both formal and informal forums. The problem for beginners in the community in public speaking is language skills, systematic and mental. This qualitative research method uses andragogy learning approach. The results of this study include public speaking training activities to improve their language skills. By using the training method obtained satisfactory results. Through this activity activity can increase the potential of speaking ability of the community of women owners of small and medium businesses in the village of Rarang. Besides being able to increase the participation of women in more formal public forums. Increasing the role of women will certainly also affect the capacity and capabilities of women in their involvement in public forums.

Pucang Village was consisted of eruption materials of Merapi Volcano. The relatively high coefficient of permeability of the materials consisting this area caused rainwater to directly infiltrate into the ground. Evaluation of engineering geological conditions was conducted for construction of a detention pond in this area, which had limited water supply for daily activities. The evaluation was conducted on results of a 1:10.000 scale of engineering geological mapping and analyses of 1:10.000 scale of geological disaster maps produced by previous researchers. The engineering geological mapping involved mapping of morphological condition and active geomorphic process, lithological condition, existence of geological structure, and water source location. The evaluation results showed that the proposed location met the land suitability criteria for detention pond construction based on the morphological condition and active geomorphic process, existence of geological structure, and water source location, but did not meet those based on the lithological and vulnerability to Merapi Volcano eruption disaster. Construction of impermeable layer to prevent water seepage into the ground and periodic removal of sediment in the base of the detention pond were suggested to be carried out to keep the detention pond functioning properly.

Latar belakang: Etiologi dan patogenesis dermatitis atopik (DA) masih belum jelas hingga saat ini. Banyak faktor diduga dapat memengaruhi terjadinya DA, salah satunya adalah peningkatan Reactive Oxygen Species (ROS) yang dapat dinilai dengan mengukur konsentrasi 8-hydroksi-2’-deoksiguanosine (8-OHdG) urin.Penelitian analitik mengenai hubungan 8-OHdG urin pasien DA dan non-DA masih jarang ditemukan dan sampai saat ini belum ada publikasi yang serupa di Indonesia. Tujuan: Membandingkan kadar 8-OHdG urin pada pasien DA anak yang sedang eksaserbasi dan non-DA anak. Metode: Desain penelitian adalah analitik observasional dengan membandingkan kadar 8-OHdG sebagai penanda urin pada pasien DA dan non-DA anak sebagai kontrol. Populasi penelitian adalah semua pasien anak (£12 tahun) dengan diagnosis DA yang sedang mengalami eksaserbasi dan non-DA yang dikonfirmasi melalui anamnesis, manifestasi klinis, dan kriteria diagnosis Hanfin Rajka di Divisi Dermatologi Anak Unit Rawat Jalan (URJ) Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya pada November 2017 sampai Februari 2017. Hasil: Nilai rerata kadar 8-OHdG urin pada pasien DA adalah 79,77 ± 31,79 ng/mg kreatinin. Nilai rerata kadar 8-OHdG urin pada pasien kontrol adalah 16,92 ± 11,18 ng/mg kreatinin. Kadar 8-OHdG urin pada pasien DA lebih besar daripada kelompok kontrol. Simpulan: Pasien DA mengalami stress oksidatif. 8-OHdG merupakan produk yang banyak ditemukan di dalam tubuh dan mudah terdeteksi akibat kerusakan DNA oksidatif, karena itu dianggap sebagai penanda yang berguna dan relevan untuk stress oksidatif.

The purpose of this study is to find out the effect of the use of information technology in the administration of Assets. Asset management is not just administrative but more than an asset manager's effort to improve efficiency, effectiveness and increase asset added value assets itself. Government regulations regulate asset management through the use of information technology in the administration of assets, including bookkeeping, inventory and reporting activities. This research was conducted in the regional government work unit of Garut Regency which has implemented the Regional Goods Cycle Information Technology Application (ATISISBADA). The results of the study concluded that the optimal use of information technology in the ATISISBADA application was able to increase the effectiveness of assets administration activities. The implications of the results of this study are efforts to solve the problems that occur, namely optimizing the use of ATISISBADA in asset management activities in regional government.

Total production of dairy farmers in Indonesia are accounted for less than a quarter of the national dairy consumption. Most of dairy farmers in Indonesia are coordinated by cooperative. Therefore, the right strategy is needed to strengthen the role of cooperatives and their members. Research is conducted in Bogor Dairy Production Cooperative (KPS Bogor), Bogor District. The research is offering Business Development Strategy of dairy cooperative using Strengths, Weaknesses, Opportunities, and Threats (SWOT) analysis and Quantitative Strategic Planning Matrix (QSPM) methods. The results showed the internal and external (IE) indicators in KPS Bogor. IE Matrix showed that KPS Bogor stands in five quadrant. The general strategies are market penetration and product development. Based on matrix of SWOT method, there are six alternative strategies. QSPM results showed the highest priority strategy for KPS Bogor are: (1) Strategy to develop derivative products of milk, (2) Strategy to increase the number of dairy farmers, (3) Strategy to provide credit facilities for members of the cooperative, (4) Strategy to improve milk quality standards, (5) Strategy to expand the distribution network, and (6) Strategy to clarify goals of KPS Bogor.

PT Aplikasi Karya Anak Bangsa or Gojek is an online transportation service company that was founded in 2010.The research objective is to analyze and describe Gojek's marketing strategy through YouTube social media. This research uses a qualitative approach, with analysis using netnographic studies. The research subjects are 20 netizens who commented on Gojek's Indonesian Youtube account related to the video marketing advertising Gojek. The results showed that Gojek's marketing strategy made use of the internet as a means to promote the services offered. The promotion process is very intensively carried out by the Gojek Company, one of which is through social media. With the sophistication of advertising done through media social, users will automatically be treated to various promotions from the CompanyGojek when opening its social media pages. This strategy is very appropriate because almost the entire process of purchasing a Gojek service is done ina smartphone application, this means that the potential consumers targeted are in accordance with the ad audience that is installed. The conclusion in this study is the implementation of marketing 7P on online Gojek services which include: product, price, place, people, process, and physical evidence has been implemented well.

This research was conducted to develop discovery learning-based E-modulees combined with PhET in kinetik gas theory materials with the aim of: 1) producing discovery learning-based E-modulee products in the analysekinetik theory of gassesmaterial subjects for students. (2) knowing the feasibility of discovery learning-based E-modulee products in kinetik gas theory material for students. referring to the R&D (reaserch and development) method of the step of development refers to Thiagarajan (4D) which has been adapted to the purpose of research only until the development stage. The development procedures in this study include define, design, and development. This research resulted in a product in the form of discovery learning based emodules on the subject matter of kinetik gas for students with a decent category. Based on the results of validation by experts, the overall product feasibility percentage is 87.7%, which means that the product falls into very valid criteria. The readability test conducted on 14 students of physics education UM obtained an average reading result of 96.4% of the readability criteria included in the legible category.

Tujuan dari penelitian ini adalah bagaimana pembelajaran matematika disajikan di masa pandemi covid-19 dengan pendekatan matematika realistik. Aplikasi apa saja dan media apa saja yang digunakan dalam pembelajaran matematika secara daring di masa pandemic. Metode yang digunakan dalam penelitian ini adalah penelitian tindakan kelas, terdapat perbedaan kelas yang dimaksud disini adalah kelas virtual. Penelitian ini dilakukan pada siswa kelas VIII semester 2 tahun pelajaran 2019/2020. Hasil penelitian ini adalah ada beberapa aplikasi yang digunakan dalam menunjang pembelajaran matematika selama masa pandemic dengan pendeketan matematika realistik yaitu media sosial whatsapp group, google class room, google form, zoom meting dan google meet. Selanjutnya media pembelajaran yang digunakan adalah barang-barang pribadi yang ada dirumah dan dalam kehidupan sehari-hari siswa gunakan ketika belajar tentang lingkaran maka yang digunakan sebagai alat peraga yang memang sehari-hari siswa gunakan untuk dijadikan sebagai media pembelajaran yang bentuknya lingkaran seperti ban sepeda, hula hup, birbir gelas dan lain sebagainya. Adapula kedala dalam pembelajaran daring yaitu keterbatasan inftastuktur penunjang kegiatan pembelajaran dan juga kuota intenet yang menyedot cukup banyak kuota internet siswa dan guru. The purpose of this study is how mathematics learning is presented during the Covid-19 pandemic with a realistic mathematics approach. What applications and media are used in online mathematics learning during a pandemik. The method used in this research is classroom action research, there are differences in the class referred to here, namely the virtual class. This research was conducted on class VIII students in semester 2 of the 2019/2020 academic year. The results of this study are that there are several applications used to support mathematics learning during the pandemic with realistic mathematics approaches, namely social media WhatsApp group, google class room, google form, zoom meting and google meet. Furthermore, the learning media used are personal items at home and in everyday life students use when learning about circles, they are used as props that students use everyday to serve as learning media in a circle like bicycle tires, hula hup, beer glass and so on. There are also problems in online learning, namely the limitations of the infrastructure to support learning activities and also the internet quota which takes up quite a lot of internet quota for students and teacher.

Latar Belakang: Xeroderma pigmentosum (XP) adalah penyakit yang jarang, diturunkan secara autosomal resesif dengan gangguan pada perbaikan deoxyribonucleic acid (DNA) yang sering mengakibatkan keganasan. Pada XP terdapat lesi DNA yang tidak dapat diperbaiki dan mutasi gen yang mengatur perkembangan kanker kulit. Tujuan: Menjelaskan patogenesis molekular dan genetik XP, terutama tumor suppressor gen dan mutasi onkogen. Telaah Kepustakaan: Pasien XP dengan radiasi sinar ultraviolet (UV) menghasilkan perkembangan yang tinggi dari squamous cell carcinoma (SCC), basal cell carcinoma (BCC), dan melanoma maligna (MM). Hal itu bisa dikarenakan hipersensitifitas akut perbaikan DNA yang tidak sempurna karena mutasi tumor suppressor gen (gen p53, INK-ARF, dan PTCH) dan gen Ras pada proto-onkogen (Ha-ras, Ki-ras, dan N-ras). Simpulan: Deteksi mutasi gen dapat dilakukan mengggunakan polymerase chain reaction (PCR) dan single strand conformation polymorphism (SSCP-PCR).

This research aims to know the influence of the role of self efficacy towards solving math problems in terms of positive thinking. The method used was survey methods with quantitative approach and hypothesis testing using path analysis. Large sample as many as 140 students, with sampling the sampling technique used was saturated. The results of hypothesis testing indicate that: 1) there is a significant direct influence on self efficacy against the ability of solving math problems, with the line coefficient of 0.187 and contribute directly towards the ability of self efficacy the mathematical problem solving of 3.50%. 2) there are no significant direct influence positive thinking towards mathematical problem solving ability, with the line coefficient of 0.034 and direct contribution towards positive thinking ability of solving math problems very small even barely contribute, only amounted to 0.12%. 3) there is a significant direct influence on self efficacy against positive thinking, with a coefficient of line of direct contributions and 0.181 self-efficacy (self efficacy) toward positive thinking of 3.27%. 4) there were no significant effects of self efficacy against mathematical problem solving ability through positive thinking, with the line coefficient of 0.006.

Background: Condylomata acuminata are mostly found in adult patients through sexual contact. Non-sexual transmission should be considered in children with condylomata acuminata. There are no Food Drug Administration (FDA) guidelines approved for condyloma acuminata in children less than 12 years old. Purpose: To report two rare cases of condylomata acuminata in children. Cases: Two girls, aged 1 and 2 years old came at different times to Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Hospital with perianal tumors. Both were born by vaginal delivery. There was no history of the same disease on the genital or the skin of both parents. Physical examinations on the perianal area were multiple flesh-colored papules with ‘cauliflower’ appearance. There was no sign or symptom of sexual abuse. Histopathological examinations in both patient show epidermis with hyperkeratosis, acanthosis, papilomatosis, some epithelial cell show koilocytosis. On the dermis layer there were proliferation from capillary blood vessel, infiltration mononuclear, intact membrane basale and no sign of malignancy. Human papillomavirus (HPV) subtypes examination results were type 11. Discussion: Trichloroacetic acid (TCA) was giving different results on both cases. The patient who did not show improvement with TCA was consulted to pediatric surgery to get electrodessication therapy by hefrycauter. Conclusion: Accurate history and physical examination isneeded to determine the mode transmissions of condylomata acuminata in children. Human papillomavirus (HPV) subtypes examination is not routinely performed and has limitation to determine the mode of transmission, especially in children. Perinatal transmission should be considered in children up to 2 years old. Multiple modalities are available for the treatment of warts in children.

Abstract Shrimp is one source of protein that people like. Shrimps have major weaknesses that are susceptible to decay due to physiological, mechanical, and microbiological influences. One effort to process and preserve the simple and easy fishery is fermentation. The salt concentration used in shrimp fermentation greatly determines the quality of the shrimp. The purpose of this study was to determine the effect of salt concentration (20%, 25% and 30%) on shrimp fermentation process for seven days. The method used in this study is experimental and the parameters used in this research are temperature, pH, total organic acid, microbiological analysis and organoleptic test (including aroma, taste and texture). The results show that shrimp fermentation with 25% concentration has the best quality compared to shrimp fermentation that use concentration 20% and 30%. Keywords: shrimp, fermentation, salt concentration.