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2. Longitudinal study of inflammation and relapse in schizophrenia

Author

Miller, Brian J., Lemos, Henrique, Schooler, Nina R., Goff, Donald C., Kopelowicz, Alexander, Lauriello, John, Manschreck, Theo, Mendelowitz, Alan, Miller, Del D., Severe, Joanne B., Wilson, Daniel R., Ames, Donna, Bustillo, Juan, Kane, John M., Rapaport, Mark H., and Buckley, Peter F.

Published
2023
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3. Consistency checks to improve measurement with the Positive and Negative Syndrome Scale (PANSS)

Author

Rabinowitz, Jonathan, Schooler, Nina R, Anderson, Ariana, Ayearst, Lindsay, Daniel, David, Davidson, Michael, Khan, Anzalee, Kinon, Bruce, Menard, Francois, Opler, Lewis, Opler, Mark, Severe, Joanne B, Williamson, David, Yavorsky, Christian, Zhao, Jun, and members, ISCTM ALGORITHMS FLAGS TO IDENTIFY CLINICAL INCONSISTENCY IN THE USE OF RATING SCALES IN CNS RCTs working group

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Clinical Trials as Topic, Databases as Topic, Humans, Psychiatric Status Rating Scales, Quality Improvement, Reproducibility of Results, Schizophrenia, ISCTM ALGORITHMS/FLAGS TO IDENTIFY CLINICAL INCONSISTENCY IN THE USE OF RATING SCALES IN CNS RCTs working group members, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences
Abstract

International Society for CNS Clinical Trials and Methodology convened an expert working-group that assembled consistency/inconsistency flags for the Positive and Negative Syndrome Scale (PANSS). Twenty-four flags were identified and divided based on extent to which they represent error (Possibly, Probably, Very probably or definitely). The flags were applied to assessments derived from the NEWMEDS data repository and the CATIE clinical trial data. Almost 40% of ratings had at least one inconsistency flag raised and 10% had two. Application of flags to clinical rating can improve reliability and validity of trials.

Published
2017

4. Childhood Predictors of Adult Functional Outcomes in the Multimodal Treatment Study of Attention-Deficit/Hyperactivity Disorder (MTA)

Author

Roy, Arunima, Hechtman, Lily, Arnold, L Eugene, Swanson, James M, Molina, Brooke SG, Sibley, Margaret H, Howard, Andrea L, Group, MTA Cooperative, Vitiello, Benedetto, Severe, Joanne B, Jensen, Peter S, Hoagwood, Kimberly, Richters, John, Vereen, Donald, Hinshaw, Stephen P, Elliott, Glen R, Wells, Karen C, Epstein, Jeffery N, Murray, Desiree W, Conners, C Keith, March, John, Swanson, James, Wigal, Timothy, Cantwell, Dennis P, Abikoff, Howard B, Greenhill, Laurence L, Newcorn, Jeffrey H, Molina, Brooke, Hoza, Betsy, Pelham, William E, Gibbons, Robert D, Marcus, Sue, Hur, Kwan, Kraemer, Helena C, Hanley, Thomas, and Stern, Karen

Subjects
Clinical and Health Psychology, Psychology, Prevention, Brain Disorders, Pediatric, Behavioral and Social Science, Pediatric Research Initiative, Clinical Research, Mental Health, Attention Deficit Hyperactivity Disorder (ADHD), 2.3 Psychological, social and economic factors, Aetiology, Quality Education, Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Child, Educational Status, Emotions, Employment, Family, Female, Follow-Up Studies, Humans, Income, Intelligence, Male, Young Adult, attention-deficit/hyperactivity disorder, adult outcomes, functioning, Multimodal Treatment Study of ADHD study, childhood predictors, MTA Cooperative Group, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental & Child Psychology, Clinical sciences, Paediatrics, Applied and developmental psychology
Abstract

ObjectiveRecent results from the Multimodal Treatment Study of Attention-Deficit/Hyperactivity Disorder (ADHD; MTA) have demonstrated impairments in several functioning domains in adults with childhood ADHD. The childhood predictors of these adult functional outcomes are not adequately understood. The objective of the present study was to determine the effects of childhood demographic, clinical, and family factors on adult functional outcomes in individuals with and without childhood ADHD from the MTA cohort.MethodRegressions were used to determine associations of childhood factors (age range 7-10 years) of family income, IQ, comorbidity (internalizing, externalizing, and total number of non-ADHD diagnoses), parenting styles, parental education, number of household members, parental marital problems, parent-child relationships, and ADHD symptom severity with adult outcomes (mean age 25 years) of occupational functioning, educational attainment, emotional functioning, sexual behavior, and justice involvement in participants with (n = 579) and without (n = 258) ADHD.ResultsPredictors of adult functional outcomes in ADHD included clinical factors such as baseline ADHD severity, IQ, and comorbidity; demographic factors such as family income, number of household members and parental education; and family factors such as parental monitoring and parental marital problems. Predictors of adult outcomes were generally comparable for children with and without ADHD.ConclusionChildhood ADHD symptoms, IQ, and household income levels are important predictors of adult functional outcomes. Management of these areas early on, through timely treatments for ADHD symptoms, and providing additional support to children with lower IQ and from households with low incomes, could assist in improving adult functioning.

Published
2017

5. Functional Adult Outcomes 16 Years After Childhood Diagnosis of Attention-Deficit/Hyperactivity Disorder: MTA Results

Author

Hechtman, Lily, Swanson, James M, Sibley, Margaret H, Stehli, Annamarie, Owens, Elizabeth B, Mitchell, John T, Arnold, L Eugene, Molina, Brooke SG, Hinshaw, Stephen P, Jensen, Peter S, Abikoff, Howard B, Algorta, Guillermo Perez, Howard, Andrea L, Hoza, Betsy, Etcovitch, Joy, Houssais, Sylviane, Lakes, Kimberley D, Nichols, J Quyen, Group, MTA Cooperative, Vitiello, Benedetto, Severe, Joanne B, Hoagwood, Kimberly, Richters, John, Vereen, Donald, Elliott, Glen R, Wells, Karen C, Epstein, Jeffery N, Murray, Desiree W, Conners, C Keith, March, John, Swanson, James, Wigal, Timothy, Cantwell, Dennis P, Greenhill, Laurence L, Newcorn, Jeffrey H, Molina, Brooke, Pelham, William E, Gibbons, Robert D, Marcus, Sue, Hur, Kwan, Kraemer, Helena C, Hanley, Thomas, and Stern, Karen

Subjects
Clinical and Health Psychology, Psychology, Clinical Research, Brain Disorders, Attention Deficit Hyperactivity Disorder (ADHD), Substance Misuse, Pediatric, Mental Health, Behavioral and Social Science, Aetiology, 2.3 Psychological, social and economic factors, Mental health, Good Health and Well Being, Adolescent, Adult, Aftercare, Attention Deficit Disorder with Hyperactivity, Child, Disease Progression, Employment, Female, Humans, Male, Substance-Related Disorders, Young Adult, ADHD, adult outcomes, follow-up, MTA, functional outcomes, MTA Cooperative Group, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental & Child Psychology, Clinical sciences, Paediatrics, Applied and developmental psychology
Abstract

ObjectiveTo compare educational, occupational, legal, emotional, substance use disorder, and sexual behavior outcomes in young adults with persistent and desistent attention-deficit/hyperactivity disorder (ADHD) symptoms and a local normative comparison group (LNCG) in the Multimodal Treatment Study of Children with ADHD (MTA).MethodData were collected 12, 14, and 16 years postbaseline (mean age 24.7 years at 16 years postbaseline) from 476 participants with ADHD diagnosed at age 7 to 9 years, and 241 age- and sex-matched classmates. Probands were subgrouped on persistence versus desistence of DSM-5 symptom count. Orthogonal comparisons contrasted ADHD versus LNCG and symptom-persistent (50%) versus symptom-desistent (50%) subgroups. Functional outcomes were measured with standardized and demographic instruments.ResultsThree patterns of functional outcomes emerged. Post-secondary education, times fired/quit a job, current income, receiving public assistance, and risky sexual behavior showed the most common pattern: the LNCG group fared best, symptom-persistent ADHD group worst, and symptom-desistent ADHD group between, with the largest effect sizes between LNCG and symptom-persistent ADHD. In the second pattern, seen with emotional outcomes (emotional lability, neuroticism, anxiety disorder, mood disorder) and substance use outcomes, the LNCG and symptom-desistent ADHD group did not differ, but both fared better than the symptom-persistent ADHD group. In the third pattern, noted with jail time (rare), alcohol use disorder (common), and number of jobs held, group differences were not significant. The ADHD group had 10 deaths compared to one death in the LNCG.ConclusionAdult functioning after childhood ADHD varies by domain and is generally worse when ADHD symptoms persist. It is important to identify factors and interventions that promote better functional outcomes.

Published
2016

6. Childhood Factors Affecting Persistence and Desistence of Attention-Deficit/Hyperactivity Disorder Symptoms in Adulthood: Results From the MTA

Author

Roy, Arunima, Hechtman, Lily, Arnold, L Eugene, Sibley, Margaret H, Molina, Brooke SG, Swanson, James M, Howard, Andrea L, Group, MTA Cooperative, Vitiello, Benedetto, Severe, Joanne B, Jensen, Peter S, Hoagwood, Kimberly, Richters, John, Vereen, Donald, Hinshaw, Stephen P, Elliott, Glen R, Wells, Karen C, Epstein, Jeffery N, Murray, Desiree W, Conners, C Keith, March, John, Swanson, James, Wigal, Timothy, Cantwell, Dennis P, Abikoff, Howard B, Greenhill, Laurence L, Newcorn, Jeffrey H, Molina, Brooke, Hoza, Betsy, Pelham, William E, Gibbons, Robert D, Marcus, Sue, Hur, Kwan, Kraemer, Helena C, Hanley, Thomas, and Stern, Karen

Subjects
Clinical and Health Psychology, Psychology, Brain Disorders, Mental Health, Prevention, Attention Deficit Hyperactivity Disorder (ADHD), Pediatric, Clinical Research, Behavioral and Social Science, Pediatric Research Initiative, 2.3 Psychological, social and economic factors, Aetiology, Mental health, Good Health and Well Being, Adult, Attention Deficit Disorder with Hyperactivity, Child, Child of Impaired Parents, Disease Progression, Female, Follow-Up Studies, Humans, Male, Mental Disorders, Parents, Severity of Illness Index, attention-deficit/hyperactivity disorder, adulthood, family, comorbidity, IQ, MTA Cooperative Group, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental & Child Psychology, Clinical sciences, Paediatrics, Applied and developmental psychology
Abstract

ObjectiveTo determine childhood factors that predict attention-deficit/hyperactivity disorder (ADHD) persistence and desistence in adulthood.MethodRegression analyses were used to determine associations between childhood factors and adult ADHD symptom persistence in 453 participants (mean age, 25 years) from the Multimodal Treatment Study of Children with ADHD (MTA). Childhood IQ, total number of comorbidities, child-perceived parenting practices, child-perceived parent-child relationships, parental mental health problems, marital problems of parents, household income levels, and parental education were assessed at a mean age of 8 years in all participants. Adult ADHD persistence was defined using DSM-5 symptom counts either with or without impairment, as well as mean ADHD symptom scores on the Conners' Adult ADHD Rating Scale (CAARS). Age, sex, MTA site, and childhood ADHD symptoms were covaried.ResultsThe most important childhood predictors of adult ADHD symptom persistence were initial ADHD symptom severity (odds ratio [OR] = 1.89, standard error [SE] = 0.28, p = .025), comorbidities (OR = 1.19, SE = 0.07, p = .018), and parental mental health problems (OR = 1.30, SE = 0.09, p = .003). Childhood IQ, socioeconomic status, parental education, and parent-child relationships showed no associations with adult ADHD symptom persistence.ConclusionInitial ADHD symptom severity, parental mental health, and childhood comorbidity affect persistence of ADHD symptoms into adulthood. Addressing these areas early may assist in reducing adult ADHD persistence and functioning problems.

Published
2016

9. Childhood Predictors of Adult Functional Outcomes in the Multimodal Treatment Study of Attention-Deficit/Hyperactivity Disorder (MTA)

Author

Vitiello, Benedetto, Severe, Joanne B., Jensen, Peter S., Arnold, L. Eugene, Hoagwood, Kimberly, Richters, John, Vereen, Donald, Hinshaw, Stephen P., Elliott, Glen R., Wells, Karen C., Epstein, Jeffery N., Murray, Desiree W., Conners, C. Keith, March, John, Swanson, James, Wigal, Timothy, Cantwell, Dennis P., Abikoff, Howard B., Hechtman, Lily, Greenhill, Laurence L., Newcorn, Jeffrey H., Molina, Brooke, Hoza, Betsy, Pelham, William E., Gibbons, Robert D., Marcus, Sue, Hur, Kwan, Kraemer, Helena C., Hanley, Thomas, Stern, Karen, Roy, Arunima, Swanson, James M., Molina, Brooke S.G., Sibley, Margaret H., and Howard, Andrea L.

Published
2017
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10. Functional Adult Outcomes 16 Years After Childhood Diagnosis of Attention-Deficit/Hyperactivity Disorder: MTA Results

Author

Vitiello, Benedetto, Severe, Joanne B., Jensen, Peter S., Arnold, L. Eugene, Hoagwood, Kimberly, Richters, John, Vereen, Donald, Hinshaw, Stephen P., Elliott, Glen R., Wells, Karen C., Epstein, Jeffery N., Murray, Desiree W., Conners, C. Keith, March, John, Swanson, James, Wigal, Timothy, Cantwell, Dennis P., Abikoff, Howard B., Hechtman, Lily, Greenhill, Laurence L., Newcorn, Jeffrey H., Molina, Brooke, Hoza, Betsy, Pelham, William E., Gibbons, Robert D., Marcus, Sue, Hur, Kwan, Kraemer, Helena C., Hanley, Thomas, Stern, Karen, Swanson, James M., Sibley, Margaret H., Stehli, Annamarie, Owens, Elizabeth B., Mitchell, John T., Molina, Brooke S.G., Perez Algorta, Guillermo, Howard, Andrea L., Etcovitch, Joy, Houssais, Sylviane, Lakes, Kimberley D., and Nichols, J. Quyen

Published
2016
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11. Childhood Factors Affecting Persistence and Desistence of Attention-Deficit/Hyperactivity Disorder Symptoms in Adulthood: Results From the MTA

Author

Vitiello, Benedetto, Severe, Joanne B., Jensen, Peter S., Arnold, L. Eugene, Hoagwood, Kimberly, Richters, John, Vereen, Donald, Hinshaw, Stephen P., Elliott, Glen R., Wells, Karen C., Epstein, Jeffery N., Murray, Desiree W., Conners, C. Keith, March, John, Swanson, James, Wigal, Timothy, Cantwell, Dennis P., Abikoff, Howard B., Hechtman, Lily, Greenhill, Laurence L., Newcorn, Jeffrey H., Molina, Brooke, Hoza, Betsy, Pelham, William E., Gibbons, Robert D., Marcus, Sue, Hur, Kwan, Kraemer, Helena C., Hanley, Thomas, Stern, Karen, Roy, Arunima, Sibley, Margaret H., Molina, Brooke S.G., Swanson, James M., and Howard, Andrea L.

Published
2016
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12. Outcomes During and After Early Intervention Services for First-Episode Psychosis: Results Over 5 Years From the RAISE-ETP Site-Randomized Trial

Author

Robinson, Delbert G, primary, Schooler, Nina R, additional, Marcy, Patricia, additional, Gibbons, Robert D, additional, Hendricks Brown, C, additional, John, Majnu, additional, Mueser, Kim T, additional, Penn, David L, additional, Rosenheck, Robert A, additional, Addington, Jean, additional, Brunette, Mary F, additional, Correll, Christoph U, additional, Estroff, Sue E, additional, Mayer-Kalos, Piper S, additional, Gottlieb, Jennifer D, additional, Glynn, Shirley M, additional, Lynde, David W, additional, Gingerich, Susan, additional, Pipes, Ronny, additional, Miller, Alexander L, additional, Severe, Joanne B, additional, and Kane, John M, additional

Published
2022
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13. Treatment-Related Changes in Objectively Measured Parenting Behaviors in the Multimodal Treatment Study of Children with Attention-Deficit/Hyperactivity Disorder

Author

Wells, Karen C., Chi, Terry C., Hinshaw, Stephen P., Epstein, Jeffery N., Pfiffner, Linda, Nebel-Schwalm, Marie, Owens, Elizabeth B., Arnold, L. Eugene, Abikoff, Howard B., Conners, C. Keith, Elliott, Glen R., Greenhill, Laurence L., Hechtman, Lily, Hoza, Betsy, Jensen, Peter S., March, John, Newcorn, Jeffrey H., Pelham, William E., Severe, Joanne B., Swanson, James, Vitiello, Benedetto, and Wigal, Timothy

Abstract

The present study examined treatment outcomes for objectively measured parenting behavior in the Multimodal Treatment Study of Children with Attention-Deficit/Hyperactivity Disorder (ADHD). Five hundred seventy-nine ethnically and socioeconomically diverse children with ADHD-combined type (ages 7.0-9.9 years) and their parent(s) were recruited at 6 sites in the United States and Canada and randomly assigned to 1 of 4 treatment groups for 14 months of active intervention: medication management (MedMgt), intensive behavior therapy, combination of the 2 (Comb), or a community-treated comparison (CC). Baseline and posttreatment laboratory observations of parent-child interactions were coded by observers blind to treatment condition. Comb produced significantly greater improvements in constructive parenting than did MedMgt or CC, with effect sizes approaching medium for these contrasts. Treatment effects on child behaviors were not significant. The authors discuss the importance of changes in parenting behavior for families of children with ADHD and the need for reliable and objective measures in evaluating treatment outcome.

Published
2006

14. Assessing Medication Effects in the MTA Study Using Neuropsychological Outcomes

Author

Epstein, Jeffery N., Conners, C. Keith, Hervey, Aaron S., Tonev, Simon T., Arnold, L. Eugene, Abikoff, Howard B., Elliott, Glen, Greenhill, Laurence L., Hechtman, Lily, Hoagwood, Kimberly, Hinshaw, Stephen P., Hoza, Betsy, Jensen, Peter S., March, John S., Newcorn, Jeffrey H., Pelham, William E., Severe, Joanne B., Swanson, James M., Wells, Karen, Vitiello, Benedetto, and Wigal, Timothy

Abstract

Background: While studies have increasingly investigated deficits in reaction time (RT) and RT variability in children with attention deficit/hyperactivity disorder (ADHD), few studies have examined the effects of stimulant medication on these important neuropsychological outcome measures. Methods: 316 children who participated in the Multimodal Treatment Study of Children with ADHD (MTA) completed the Conners' Continuous Performance Test (CPT) at the 24-month assessment point. Outcome measures included standard CPT outcomes (e.g., errors of commission, mean hit reaction time (RT)) and RT indicators derived from an Ex-Gaussian distributional model (i.e., mu, sigma, and tau). Results: Analyses revealed significant effects of medication across all neuropsychological outcome measures. Results on the Ex-Gaussian outcome measures revealed that stimulant medication slows RT and reduces RT variability. Conclusions: This demonstrates the importance of including analytic strategies that can accurately model the actual distributional pattern, including the positive skew. Further, the results of the study relate to several theoretical models of ADHD.

Published
2006
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16. Delinquent Behavior and Emerging Substance Use in the MTA at 36 Months: Prevalence, Course, and Treatment Effects

Author

MOLINA, BROOKE S.G., FLORY, KATE, HINSHAW, STEPHEN P., GREINER, ANDREW R., ARNOLD, L. EUGENE, SWANSON, JAMES M., HECHTMAN, LILY, JENSEN, PETER S., VITIELLO, BENEDETTO, HOZA, BETSY, PELHAM, WILLIAM E., ELLIOTT, GLEN R., WELLS, KAREN C., ABIKOFF, HOWARD B., GIBBONS, ROBERT D., MARCUS, SUE, CONNERS, C. KEITH, EPSTEIN, JEFFERY N., GREENHILL, LAURENCE L., MARCH, JOHN S., NEWCORN, JEFFREY H., SEVERE, JOANNE B., and WIGAL, TIMOTHY

Published
2007
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17. Secondary Evaluations of MTA 36-Month Outcomes: Propensity Score and Growth Mixture Model Analyses

Author

SWANSON, JAMES M., HINSHAW, STEPHEN P., ARNOLD, L. EUGENE, GIBBONS, ROBERT D., MARCUS, SUE, HUR, KWAN, JENSEN, PETER S., VITIELLO, BENEDETTO, ABIKOFF, HOWARD B., GREENHILL, LAURENCE L., HECHTMAN, LILY, PELHAM, WILLIAM E., WELLS, KAREN C., CONNERS, C. KEITH, MARCH, JOHN S., ELLIOTT, GLEN R., EPSTEIN, JEFFERY N., HOAGWOOD, KIMBERLY, HOZA, BETSY, MOLINA, BROOKE S.G., NEWCORN, JEFFREY H., SEVERE, JOANNE B., and WIGAL, TIMOTHY

Published
2007
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18. 3-Year Follow-up of the NIMH MTA Study

Author

JENSEN, PETER S., ARNOLD, L. EUGENE, SWANSON, JAMES M., VITIELLO, BENEDETTO, ABIKOFF, HOWARD B., GREENHILL, LAURENCE L., HECHTMAN, LILY, HINSHAW, STEPHEN P., PELHAM, WILLIAM E., WELLS, KAREN C., CONNERS, C. KEITH, ELLIOTT, GLEN R., EPSTEIN, JEFFERY N., HOZA, BETSY, MARCH, JOHN S., MOLINA, BROOKE S.G., NEWCORN, JEFFREY H., SEVERE, JOANNE B., WIGAL, TIMOTHY, GIBBONS, ROBERT D., and HUR, KWAN

Published
2007
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19. Nine Months of Multicomponent Behavioral Treatment for ADHD and Effectiveness of MTA Fading Procedures

Author

Arnold, L. Eugene, Chuang, Shirley, Davies, Mark, Abikoff, Howard B., Conners, C. Keith, Elliott, Glen R., Greenhill, Laurence L., Hechtman, Lily, Hinshaw, Stephen P., Hoza, Betsy, Jensen, Peter S., Kraemer, Helena C., Langworthy-Lam, Kristen S., March, John S., Newcorn, Jeffrey H., Pelham, William E., Severe, Joanne B., Swanson, James M., Vitiello, Benedetto, Wells, Karen C., and Wigal, Timothy

Published
2004
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20. Observed Classroom Behavior of Children with ADHD: Relationship to Gender and Comorbidity

Author

Abikoff, Howard B., Jensen, Peter S., Arnold, L. L. Eugene, Hoza, Betsy, Hechtman, Lily, Pollack, Simcha, Martin, Diane, Alvir, Jose, March, John S., Hinshaw, Stephen, Vitiello, Benedetto, Newcorn, Jeffrey, Greiner, Andrew, Cantwell, Dennis P., Conners, C. Keith, Elliott, Glen, Greenhill, Laurence L., Kraemer, Helena, Pelham, Jr., William E., Severe, Joanne B., Swanson, James M., Wells, Karen, and Wigal, Tim

Published
2002
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21. Effects of ethnicity on treatment attendance, stimulant response/dose, and 14-month outcome in ADHD

Author

Arnold, L. Eugene, Elliott, Michael, Sachs, Larry, Kraemer, Helena C., Abikoff, Howard B., Conners, C. Keith, Greenhill, Laurence L., Hinshaw, Stephen P., Jensen, Peter S., Newcorn, Jeffrey H., Severe, Joanne B., Vitiello, Benedetto, Bird, Hector, Wells, Karen C., Comarda, Anne, Elliott, Glen R., Hechtman, Lily, Hoza, Betsy, March, John S., Pelham, William E., Swanson, James M., and Wigal, Timothy

Subjects
Child psychopathology -- Care and treatment, Attention-deficit hyperactivity disorder -- Care and treatment, Psychology and mental health
Abstract

From the Multimodal Treatment Study of Children with Attention-Deficit/Hyperactivity Disorder--a randomized clinical trial of 579 children ages 7-9 years receiving 14 months of medication management, behavioral treatment, combination, or community care--the authors matched each African American and Latino participant with randomly selected Caucasian participants of same sex, treatment group, and site. Although Caucasian children were significantly less symptomatic than African American and Latino children on some ratings, response to treatment did not differ significantly by ethnicity after controlling for public assistance. Ethnic minority families cooperated with and benefited significantly from combination (multimodal) treatment (d = 0.36, compared with medication). This incremental gain withstood statistical control for mother's education, single-parent status, and public assistance. Treatment for lower socioeconomic status minority children, especially if comorbid, should combine medication and behavioral treatment.

Published
2003

22. Which treatment for whom for ADHD? Moderators of treatment response in the MTA

Author

Owens, Elizabeth B., Hinshaw, Stephen P., Arnold, L. Eugene, Cantwell, Dennis P., Elliott, Glen, Hechtman, Lily, Jensen, Peter S., Newcorn, Jeffrey H., Severe, Joanne B., Vitiello, Benedetto, Kraemer, Helen C., Abikoff, Howard B., Conners, C. Keith, Greenhill, Laurence L., Hoza, Betsy, March, John S., Pelham, William E., Swanson, James M., Wells, Karen C., and Wigal, Timothy

Subjects
Attention-deficit hyperactivity disorder -- Care and treatment, Child psychopathology -- Care and treatment, Psychology and mental health
Abstract

Using receiver operating characteristics, the authors examined outcome predictors (variables associated with outcome regardless of treatment) and moderators (variables identifying subgroups with differential treatment effectiveness) in the Multimodal Treatment Study of Children with Attention-Deficit/Hyperactivity Disorder (ADHD; MTA). Treatment response was determined using parent- and teacher-reported ADHD and oppositional defiant symptoms, with levels near or within the normal range indicating excellent response. Among 9 baseline child and family characteristics, none predicted but 3 moderated treatment response. In medication management and combined treatments, parental depressive symptoms and severity of child ADHD were associated with decreased rates of excellent response; when these 2 characteristics were present, below-average child IQ was an additional moderator. No predictors or moderators emerged for behavioral and community comparison treatments. The authors discuss conceptual and clinical implications of research on treatment moderators.

Published
2003

23. Emergency/adjunct services and attrition prevention for randomized clinical trials in children: the MTA manual-based solution. (Special Communication)

Author

Abikoff, Howard, Arnold, L. Eugene, Newcorn, Jeffrey H., Elliott, Glen R., Hechtman, Lily, Severe, Joanne B., Wigal, Timothy, Shapiro, Cheri, Cantwell, Dennis P., Conners, C. Keith, Greenhill, Laurence L., Hinshaw, Stephen P., Hoza, Betsy, Jensen, Peter S., Kraemer, Helena C., March, John S., Pelham, William E., Swanson, James M., Vitiello, Benedetto, and Wells, Karen C.

Subjects
Clinical trials -- Quality management, Clinical medicine -- Practice, Research -- Methods, Family and marriage, Psychology and mental health
Published
2002

24. SocioEconomic Status as a moderator of ADHD treatment outcomes

Author

Rieppi, Ricardo, Greenhill, Laurence L., Ford, Rebecca E., Chuang, Shirley, Wu, Min, Davies, Mark, Abikoff, Howard B., Arnold, L. Eugene, Conners, C. Keith, Elliott, Glen R., Hechtman, Lily, Hinshaw, Stephen P., Hoza, Betsy, Jensen, Peter S., Kraemer, Helena C., March, John S., Newcorn, Jeffrey H., Pelham, William E., Severe, Joanne B., Swanson, James M., Vitiello, Benedetto, Wells, Karen C., and Wigal, Timothy

Subjects
Attention-deficit hyperactivity disorder -- Care and treatment, Social status -- Research, Family and marriage, Psychology and mental health
Published
2002

26. Medication treatment strategies in the MTA study: relevance to clinicians and researchers

Author

Greenhill, Laurence L., Abikoff, Howard B., Arnold, L. Eugene, Cantwell, Dennis P., Conners, C. Keith, Elliott, Glen, Hechtman, Lily, Hinshaw, Stephen P., Hoza, Betsy, Jensen, Peter S., March, John S., Newcorn, Jeffrey, Pelham, William E., Severe, Joanne B., Swanson, James M., Vitiello, Ben, and Wells, Karen

Subjects
United States. National Institute of Mental Health -- Research, Attention-deficit hyperactivity disorder -- Drug therapy, Drugs -- Prescribing, Drug therapy -- Methods, Family and marriage, Psychology and mental health
Published
1996

27. Peer-Assessed Outcomes in the Multimodal Treatment Study of Children With Attention Deficit Hyperactivity Disorder

Author

Hoza, Betsy, Gerdes, Alyson C., Mrug, Sylvie, Hinshaw, Stephen P., Bukowski, William M., Gold, Joel A., Arnold, L. Eugene, Abikoff, Howard B., Conners, C. Keith, Elliott, Glen R., Greenhill, Laurence L., Hechtman, Lily, Jensen, Peter S., Kraemer, Helena C., March, John S., Newcorn, Jeffrey H., Severe, Joanne B., Swanson, James M., Vitiello, Benedetto, Wells, Karen C., and Wigal, Timothy

Subjects
Psychology, Pathological -- Research, Psychological research -- Methods, Attention-deficit hyperactivity disorder -- Care and treatment, Attention-deficit hyperactivity disorder -- Patient outcomes, Interpersonal relations in children -- Psychological aspects, Interpersonal relations in children -- Evaluation, Child psychotherapy -- Practice, Psychology and mental health
Published
2005

28. National Institute of Mental Health Collaborative Multimodal Treatment Study of Children With ADHD (the MTA): Design Challenges and Choices

Author

Arnold, L. Eugene, Abikoff, Howard B., Cantwell, Dennis P., Conners, C. Keith, Elliott, Glen, Greenhill, Laurence L., Hechtman, Lily, Hinshaw, Stephen P., Hoza, Betsy, Jensen, Peter S., Kraemer, Helena C., March, John S., Newcorn, Jeffrey H., Pelham, William E., Richters, John E., Schiller, Ellen, Severe, Joanne B., Swanson, James M., Vereen, Donald, and Wells, Karen C.

Published
1997

30. Comparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis:A Systematic Review, Meta-analysis, and Meta-regression

Author

Correll, Christoph U, Galling, Britta, Pawar, Aditya, Krivko, Anastasia, Bonetto, Chiara, Ruggeri, Mirella, Craig, Thomas J, Nordentoft, Merete, Srihari, Vinod H, Guloksuz, Sinan, Hui, Christy L M, Chen, Eric Y H, Valencia, Marcelo, Juarez, Francisco, Robinson, Delbert G, Schooler, Nina R, Brunette, Mary F, Mueser, Kim T, Rosenheck, Robert A, Marcy, Patricia, Addington, Jean, Estroff, Sue E, Robinson, James, Penn, David, Severe, Joanne B, Kane, John M, Correll, Christoph U, Galling, Britta, Pawar, Aditya, Krivko, Anastasia, Bonetto, Chiara, Ruggeri, Mirella, Craig, Thomas J, Nordentoft, Merete, Srihari, Vinod H, Guloksuz, Sinan, Hui, Christy L M, Chen, Eric Y H, Valencia, Marcelo, Juarez, Francisco, Robinson, Delbert G, Schooler, Nina R, Brunette, Mary F, Mueser, Kim T, Rosenheck, Robert A, Marcy, Patricia, Addington, Jean, Estroff, Sue E, Robinson, James, Penn, David, Severe, Joanne B, and Kane, John M

Abstract

Importance: The value of early intervention in psychosis and allocation of public resources has long been debated because outcomes in people with schizophrenia spectrum disorders have remained suboptimal.Objective: To compare early intervention services (EIS) with treatment as usual (TAU) for early-phase psychosis.Data Sources: Systematic literature search of PubMed, PsycINFO, EMBASE, and ClinicalTrials.gov without language restrictions through June 6, 2017.Study Selection: Randomized trials comparing EIS vs TAU in first-episode psychosis or early-phase schizophrenia spectrum disorders.Data Extraction and Synthesis: This systematic review was conducted according to PRISMA guidelines. Three independent investigators extracted data for a random-effects meta-analysis and prespecified subgroup and meta-regression analyses.Main Outcomes and Measures: The coprimary outcomes were all-cause treatment discontinuation and at least 1 psychiatric hospitalization during the treatment period.Results: Across 10 randomized clinical trials (mean [SD] trial duration, 16.2 [7.4] months; range, 9-24 months) among 2176 patients (mean [SD] age, 27.5 [4.6] years; 1355 [62.3%] male), EIS was associated with better outcomes than TAU at the end of treatment for all 13 meta-analyzable outcomes. These outcomes included the following: all-cause treatment discontinuation (risk ratio [RR], 0.70; 95% CI, 0.61-0.80; P < .001), at least 1 psychiatric hospitalization (RR, 0.74; 95% CI, 0.61-0.90; P = .003), involvement in school or work (RR, 1.13; 95% CI, 1.03-1.24; P = .01), total symptom severity (standardized mean difference [SMD], -0.32; 95% CI, -0.47 to -0.17; P < .001), positive symptom severity (SMD, -0.22; 95% CI, -0.32 to -0.11; P < .001), and negative symptom severity (SMD, -0.28; 95% CI, -0.42 to -0.14; P < .001). Superiority of EIS regarding all outcomes was evident at 6, 9 to 12, and 18 to 24 months of treatment (except for general

Published
2018

33. Multimodal Treatment of ADHD in the MTA: An Alternative Outcome Analysis

Author

CONNERS, C. KEITH, EPSTEIN, JEFFREY N., MARCH, JOHN S., ANGOLD, ADRIAN, WELLS, KAREN C., KLARIC, JOHN, SWANSON, JAMES M., ARNOLD, L. EUGENE, ABIKOFF, HOWARD B., ELLIOTT, GLEN R., GREENHILL, LAURENCE L., HECHTMAN, LILY, HINSHAW, STEPHEN P., HOZA, BETSY, JENSEN, PETER S., KRAEMER, HELENA C., NEWCORN, JEFFREY H., PELHAM, WILLIAM E., SEVERE, JOANNE B., VITIELLO, BENEDETTO, and WIGAL, TIMOTHY

Published
2001
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34. Symptom Profiles in Children With ADHD: Effects of Comorbidity and Gender

Author

NEWCORN, JEFFREY H., HALPERIN, JEFFREY M., JENSEN, PETER S., ABIKOFF, HOWARD B., ARNOLD, L. EUGENE, CANTWELL, DENNIS P., CONNERS, C. KEITH, ELLIOTT, GLEN R., EPSTEIN, JEFFREY N., GREENHILL, LAURENCE L., HECHTMAN, LILY, HINSHAW, STEPHEN P., HOZA, BETSY, KRAEMER, HELENA C., PELHAM, WILLIAM E., SEVERE, JOANNE B., SWANSON, JAMES M., WELLS, KAREN C., WIGAL, TIMOTHY, and VITIELLO, BENEDETTO

Published
2001
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35. Clinical Relevance of the Primary Findings of the MTA: Success Rates Based on Severity of ADHD and ODD Symptoms at the End of Treatment

Author

SWANSON, JAMES M., KRAEMER, HELENA C., HINSHAW, STEPHEN P., ARNOLD, L. EUGENE, CONNERS, C. KEITH, ABIKOFF, HOWARD B., CLEVENGER, WALTER, DAVIES, MARK, ELLIOTT, GLEN R., GREENHILL, LAURENCE L., HECHTMAN, LILY, HOZA, BETSY, JENSEN, PETER S., MARCH, JOHN S., NEWCORN, JEFFREY H., OWENS, ELIZABETH B., PELHAM, WILLIAM E., SCHILLER, ELLEN, SEVERE, JOANNE B., SIMPSON, STEVE, VITIELLO, BENEDETTO, WELLS, KAREN, WIGAL, TIMOTHY, and WU, MIN

Published
2001
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36. ADHD Comorbidity Findings From the MTA Study: Comparing Comorbid Subgroups

Author

JENSEN, PETER S., HINSHAW, STEPHEN P., KRAEMER, HELENA C., LENORA, NILANTHA, NEWCORN, JEFFREY H., ABIKOFF, HOWARD B., MARCH, JOHN S., ARNOLD, L. EUGENE, CANTWELL, DENNIS P., CONNERS, C. KEITH, ELLIOTT, GLEN R., GREENHILL, LAURENCE L., HECHTMAN, LILY, HOZA, BETSY, PELHAM, WILLIAM E., SEVERE, JOANNE B., SWANSON, JAMES M., WELLS, KAREN C., WIGAL, TIMOTHY, and VITIELLO, BENEDETTO

Published
2001
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37. Impairment and Deportment Responses to Different Methylphenidate Doses in Children With ADHD: The MTA Titration Trial

Author

GREENHILL, LAURENCE L., SWANSON, JAMES M., VITIELLO, BENEDETTO, DAVIES, MARK, CLEVENGER, WALTER, WU, MIN, ARNOLD, L. EUGENE, ABIKOFF, HOWARD B., BUKSTEIN, OSCAR G., CONNERS, C. KEITH, ELLIOTT, GLEN R., HECHTMAN, LILY, HINSHAW, STEPHEN P., HOZA, BETSY, JENSEN, PETER S., KRAEMER, HELENA C., MARCH, JOHN S., NEWCORN, JEFFREY H., SEVERE, JOANNE B., WELLS, KAREN, and WIGAL, TIMOTHY

Published
2001
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38. Young adult outcomes in the follow-up of the multimodal treatment study of attention-deficit/hyperactivity disorder: symptom persistence, source discrepancy, and height suppression

Author

Swanson, James M, Arnold, L. Eugene, Molina, Brooke S. G., Sibley, Margaret H., Hechtman, Lily T., Hinshaw, Stephen P., Abikoff, Howard B., Stehli, Annamarie, Owens, Elizabeth B., Mitchell, John T., Nichols, Quyen, Howard, Andrea, Greenhill, Laurence L., Hoza, Betsy, Newcorn, Jeffrey H., Jensen, Peter S., Vitiello, Benedetto, Wigal, Timothy, Epstein, Jeffery N., Tamm, Leanne, Lakes, Kimberly D., Waxmonsky, James, Lerner, Marc, Etcovitch, Joy, Murray, Desiree W., Muenke, Maximilian, Acosta, Maria T., Arcos Burgos, Mauricio, Pelham, William E., Kraemer, Helena C., Severe, Joanne B., Richters, John, Vereen, Donald, Elliott, Glen R., Wells, Karen C., Conners, C. Keith, March, John, Cantwell, Dennis P., Gibbons, Robert D., Marcus, Sue, Hur, Kwan, Hanley, Thomas, and Stern, Karen

Subjects
Persistence (psychology), Male, Pediatrics, Outcome Assessment, Physiology, medicine.medical_treatment, Attention-deficit, Aftercare, treatment trials, Severity of Illness Index, Attention-deficit/hyperactivity disorder, follow-up studies, growth, longitudinal studies, medication effects, Pediatrics, Perinatology and Child Health, Developmental and Educational Psychology, Psychiatry and Mental Health, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Outcome Assessment, Health Care, Outcome assessment (health care), Psychology, Multimodal treatment, Young adult, MTA Cooperative Group, Child, Pediatric, 05 social sciences, Perinatology and Child Health, Combined Modality Therapy, Psychiatry and Mental health, Mental Health, hyperactivity disorder, Cognitive Sciences, Female, Attention deficit disorder, Human, 050104 developmental & child psychology, Adult, medicine.medical_specialty, Adolescent, Clinical Trials and Supportive Activities, Clinical Sciences, Developmental & Child Psychology, Pathophysiology, Article, 03 medical and health sciences, Young Adult, Clinical Research, Severity of illness, medicine, Attention deficit hyperactivity disorder, Humans, 0501 psychology and cognitive sciences, Multimodality cancer therapy, Psychiatry, Follow up, medicine.disease, Attention Deficit Hyperactivity Disorder (ADHD), Body Height, Brain Disorders, Health Care, Stimulant, Attention Deficit Disorder with Hyperactivity, Observational study, Controlled study, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

BackgroundThe Multimodal Treatment Study (MTA) began as a 14-month randomized clinical trial of behavioral and pharmacological treatments of 579 children (7-10years of age) diagnosed with attention-deficit/hyperactivity disorder (ADHD)-combined type. It transitioned into an observational long-term follow-up of 515 cases consented for continuation and 289 classmates (258 without ADHD) added as a local normative comparison group (LNCG), with assessments 2-16years after baseline.MethodsPrimary (symptom severity) and secondary (adult height) outcomes in adulthood were specified. Treatment was monitored to age 18, and naturalistic subgroups were formed based on three patterns of long-term use of stimulant medication (Consistent, Inconsistent, and Negligible). For the follow-up, hypothesis-generating analyses were performed on outcomes in early adulthood (at 25years of age). Planned comparisons were used to estimate ADHD-LNCG differences reflecting persistence of symptoms and naturalistic subgroup differences reflecting benefit (symptom reduction) and cost (height suppression) associated with extended use of medication.ResultsFor ratings of symptom severity, the ADHD-LNCG comparison was statistically significant for the parent/self-report average (0.51±0.04, p&nbsp

Published
2016

39. Mutations in sphingolipid metabolism genes are associated with ADHD.

Author

Henriquez-Henriquez, Marcela, Acosta, Maria T., Martinez, Ariel F., Vélez, Jorge I., Lopera, Francisco, Pineda, David, Palacio, Juan D., Quiroga, Teresa, Worgall, Tilla S., Deckelbaum, Richard J., Mastronardi, Claudio, Molina, Brooke S. G., the MTA Cooperative Group, Vitiello, Benedetto, Severe, Joanne B., Jensen, Peter S., Arnold, L. Eugene, Hoagwood, Kimberly, Richters, John, and Vereen, Donald R.

Published
2020
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40. Comparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis

Author

Correll, Christoph U., primary, Galling, Britta, additional, Pawar, Aditya, additional, Krivko, Anastasia, additional, Bonetto, Chiara, additional, Ruggeri, Mirella, additional, Craig, Thomas J., additional, Nordentoft, Merete, additional, Srihari, Vinod H., additional, Guloksuz, Sinan, additional, Hui, Christy L. M., additional, Chen, Eric Y. H., additional, Valencia, Marcelo, additional, Juarez, Francisco, additional, Robinson, Delbert G., additional, Schooler, Nina R., additional, Brunette, Mary F., additional, Mueser, Kim T., additional, Rosenheck, Robert A., additional, Marcy, Patricia, additional, Addington, Jean, additional, Estroff, Sue E., additional, Robinson, James, additional, Penn, David, additional, Severe, Joanne B., additional, and Kane, John M., additional

Published
2018
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41. Consistency checks to improve measurement with the Positive and Negative Syndrome Scale (PANSS)

Author

Rabinowitz, Jonathan, primary, Schooler, Nina R, additional, Anderson, Ariana, additional, Ayearst, Lindsay, additional, Daniel, David, additional, Davidson, Michael, additional, Khan, Anzalee, additional, Kinon, Bruce, additional, Menard, Francois, additional, Opler, Lewis, additional, Opler, Mark, additional, Severe, Joanne B, additional, Williamson, David, additional, Yavorsky, Christian, additional, and Zhao, Jun, additional

Published
2017
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43. Comprehensive Versus Usual Community Care For First Episode Psychosis: Two-Year Outcomes From The NIMH RAISE Early Treatment Program

Author

Kane, John M., Robinson, Delbert G., Schooler, Nina R., Mueser, Kim T., Penn, David L., Rosenheck, Robert A., Addington, Jean, Brunette, Mary F., Correll, Christoph U., Estroff, Sue E., Marcy, Patricia, Robinson, James, Meyer-Kalos, Piper S., Gottlieb, Jennifer D., Glynn, Shirley M., Lynde, David W., Pipes, Ronny, Kurian, Benji T., Miller, Alexander L., Azrin, Susan T., Goldstein, Amy B., Severe, Joanne B., Lin, Haiqun, Sint, Kyaw J., John, Majnu, and Heinssen, Robert K.

Subjects
Male, Psychotherapy, Patient Education as Topic, Psychotic Disorders, Education, Special, Employment, Supported, Schizophrenia, Humans, Female, Article, Community Mental Health Services, Antipsychotic Agents
Published
2015

44. Comprehensive Versus Usual Community Care for First-Episode Psychosis: 2-Year Outcomes From the NIMH RAISE Early Treatment Program

Author

Kane, John M., primary, Robinson, Delbert G., additional, Schooler, Nina R., additional, Mueser, Kim T., additional, Penn, David L., additional, Rosenheck, Robert A., additional, Addington, Jean, additional, Brunette, Mary F., additional, Correll, Christoph U., additional, Estroff, Sue E., additional, Marcy, Patricia, additional, Robinson, James, additional, Meyer-Kalos, Piper S., additional, Gottlieb, Jennifer D., additional, Glynn, Shirley M., additional, Lynde, David W., additional, Pipes, Ronny, additional, Kurian, Benji T., additional, Miller, Alexander L., additional, Azrin, Susan T., additional, Goldstein, Amy B., additional, Severe, Joanne B., additional, Lin, Haiqun, additional, Sint, Kyaw J., additional, John, Majnu, additional, and Heinssen, Robert K., additional

Published
2016
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46. Findings from the NIMH Multimodal Treatment Study of ADHD (MTA): Implications and Applications for Primary Care Providers

Author

JENSEN, PETER S., HINSHAW, STEPHEN P., SWANSON, JAMES M., GREENHILL, LAURENCE L., CONNERS, C. KEITH, ARNOLD, L. EUGENE, ABIKOFF, HOWARD B., ELLIOTT, GLEN, HECHTMAN, LILY, HOZA, BETSY, MARCH, JOHN S., NEWCORN, JEFFREY H., SEVERE, JOANNE B., VITIELLO, BENEDETTO, WELLS, KAREN, and WIGAL, TIMOTHY

Subjects
Attention-deficit hyperactivity disorder -- Care and treatment, Education, Health, Psychology and mental health
Published
2001

47. Lithium Treatment Moderate-Dose Use Study (LiTMUS) for Bipolar Disorder: A Randomized Comparative Effectiveness Trial of Optimized Personalized Treatment With and Without Lithium

Author

Nierenberg, Andrew A., primary, Friedman, Edward S., additional, Bowden, Charles L., additional, Sylvia, Louisa G., additional, Thase, Michael E., additional, Ketter, Terence, additional, Ostacher, Michael J., additional, Leon, Andrew C., additional, Reilly-Harrington, Noreen, additional, Iosifescu, Dan V., additional, Pencina, Michael, additional, Severe, Joanne B., additional, and Calabrese, Joseph R., additional

Published
2015
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48. Defining ADHD symptom persistence in adulthood: optimizing sensitivity and specificity.

Author

Sibley, Margaret H., Swanson, James M., Arnold, L. Eugene, Hechtman, Lily T., Owens, Elizabeth B., Stehli, Annamarie, Abikoff, Howard, Hinshaw, Stephen P., Molina, Brooke S.G., Mitchell, John T., Jensen, Peter S., Howard, Andrea L., Lakes, Kimberley D., Pelham, William E., Vitiello, Benedetto, Severe, Joanne B., Eugene Arnold, L., Hoagwood, Kimberly, Richters, John, and Vereen, Donald

Subjects
ATTENTION-deficit hyperactivity disorder, INTERVIEWING, RESEARCH methodology, RESEARCH funding, SELF-evaluation, PARENT attitudes, RECEIVER operating characteristic curves, SYMPTOMS, ADULTS
Abstract

Objective Longitudinal studies of children diagnosed with ADHD report widely ranging ADHD persistence rates in adulthood (5-75%). This study documents how information source (parent vs. self-report), method (rating scale vs. interview), and symptom threshold (DSM vs. norm-based) influence reported ADHD persistence rates in adulthood. Method Five hundred seventy-nine children were diagnosed with DSM-IV ADHD-Combined Type at baseline (ages 7.0-9.9 years) 289 classmates served as a local normative comparison group (LNCG), 476 and 241 of whom respectively were evaluated in adulthood (Mean Age = 24.7). Parent and self-reports of symptoms and impairment on rating scales and structured interviews were used to investigate ADHD persistence in adulthood. Results Persistence rates were higher when using parent rather than self-reports, structured interviews rather than rating scales (for self-report but not parent report), and a norm-based (NB) threshold of 4 symptoms rather than DSM criteria. Receiver-Operating Characteristics (ROC) analyses revealed that sensitivity and specificity were optimized by combining parent and self-reports on a rating scale and applying a NB threshold. Conclusion The interview format optimizes young adult self-reporting when parent reports are not available. However, the combination of parent and self-reports from rating scales, using an 'or' rule and a NB threshold optimized the balance between sensitivity and specificity. With this definition, 60% of the ADHD group demonstrated symptom persistence and 41% met both symptom and impairment criteria in adulthood. [ABSTRACT FROM AUTHOR]

Published
2017
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49. Lithium Treatment Moderate-Dose Use Study (LiTMUS) for Bipolar Disorder: A Randomized Comparative Effectiveness Trial of Optimized Personalized Treatment With and Without Lithium

Author

Nierenberg, Andrew A., primary, Friedman, Edward S., additional, Bowden, Charles L., additional, Sylvia, Louisa G., additional, Thase, Michael E., additional, Ketter, Terence, additional, Ostacher, Michael J., additional, Leon, Andrew C., additional, Reilly-Harrington, Noreen, additional, Iosifescu, Dan V., additional, Pencina, Michael, additional, Severe, Joanne B., additional, and Calabrese, Joseph R., additional

Published
2013
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50. Blood Pressure and Heart Rate Over 10 Years in the Multimodal Treatment Study of Children With ADHD

Author

Vitiello, Benedetto, primary, Elliott, Glen R., additional, Swanson, James M., additional, Arnold, L. Eugene, additional, Hechtman, Lily, additional, Abikoff, Howard, additional, Molina, Brooke S.G., additional, Wells, Karen, additional, Wigal, Timothy, additional, Jensen, Peter S., additional, Greenhill, Laurence L., additional, Kaltman, Jonathan R., additional, Severe, Joanne B., additional, Odbert, Carol, additional, Hur, Kwan, additional, and Gibbons, Robert, additional

Published
2012
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