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Water is a renewable resource for the Sustaining Ecosystem. Rapid industrialization and population impacts the climate. The imbalance of Climate changes over various geographical regions affects the hydrological and morphological behaviour of water resources. The Water balances of the system are analysed via the SWAT Model (Soil and Water Assessment Tool). By simulating and predicting future hydrological behaviour with different scenarios using many climatological models. Using weather data and predicting future hydrological outputs such as Runoff, Temperature, Base flow, groundwater flow, AET etc. in 21st century. Model is calibrated and validated using statistical methods. Results of various modelling Researches in field of SWAT and their major findings are discussed in this review paper. The future Scope of SWAT modelling and its Applications are also recommended. Forty papers are discussed in tabular form with their results and their future improvements were concluded. This paper fulfills a need for precise and quick reviews of recent researches in field of SWAT modelling with climate change on water resources. This will help researchers, academician’s insights into precise climate change impacts on water resources in 21st Century. Necessary steps to be adopted for their successful extreme repercussions of climate change and measures adopted for managing the severe damages to our Ecosystem with sustainable development goals in new millennium are discussed.

Oral health is a critical component of overall health and well-being. Dental caries and periodontitis are two of the most common oral diseases and, when not treated, can have irreversible sequelae and overall psychosocial and physiologic impact on individuals, diminishing quality of life. The burden of advanced dental caries and periodontal disease leading to tooth loss is severe. Physicians and allied medical professionals can help in early detection of dental caries, abscess, and periodontal diseases and initiate management followed by prompt referral to dental colleagues.

The past decade has seen a surge in the use of e-cigarettes, which has prompted the medical community to assess any associated potential health hazards. A major concern was the risk of cancer. Chemical analysis of e-cigarettes has shown the presence of volatile organic compounds with the potential for carcinogenicity. Comparative toxicology analysis has shown e-cigarette to have relatively lower dosages of toxins than conventional combustible cigarettes. Based on comparative analysis, e-cigarettes have been increasingly advocated as a safe alternative to conventional cigarettes. It is vital to recognize that presence of relatively lower toxin level does not preclude carcinogenic potential. The nicotine present in the e-cigarette was presumed to be the major cytotoxic agents, thus nicotine-free e-cigarette was considered as inert. On the contrary, experimental studies on oral cell lines have shown DNA strand breaks on exposure to e-cigarette vapors with or without nicotine. In addition, dysregulations of genes associated with carcinogenic pathways have also been demonstrated in oral tissues exposed to e-cigarette vapors. Despite alarming molecular data, the oral carcinogenic potential of e-cigarette remains unclear, which can be attributed to the lack of long-term prospective and large-scale case-control studies. As e-cigarette users often have other well-established risk factors (conventional cigarette smoking, alcohol, etc.) as associated habits, it is difficult to assess e-cigarette as an independent risk factor for oral cancer. Thus, the present manuscript aims to review the published literature using the Brad Ford Hill criteria of causation to determine the oral carcinogenic potential of e-cigarettes.

Machine learning (ML) is the ability of computers to learn from data autonomously. It is a core branch of artificial intelligence (AI), which is defined as the ability of a machine to replicate the intellectual processes of humans independently.1,2 The evolution of the microprocessor for home computers resulted in increased computing speed, efficient data collection, storage, and retrieval capacity. Thus AI techniques have evolved, which led to the discovery of artificial neural networks which are computer modeling algorithms mimicking the human brain.3-6 AI has developed to an extent that it can exceed the human brain in board games such as chess, television games, image recognition, and spam e-mail filtering. In addition to engineering, arts, and finance, extensive progress has been made to integrate ML in the field of medicine, especially oncology.

Background Spin in randomized controlled trial (RCT) abstracts can misguide clinicians. In this cross-sectional analysis, the authors assessed the prevalence of spin in RCT abstracts and explored the factors potentially influencing it. Methods In this cross-sectional analysis, the authors conducted a systematic search in top 10 dental journals based on Eigenfactor score and selected RCTs published in 2015 with statistically nonsignificant primary outcomes. The dentistry disciplines covered in these journals include general dentistry, dental research, oral implantology, endodontics, oral surgery, periodontology, and oral oncology. In these RCT abstracts, the authors assessed the prevalence of 3 different categories of spin and factors that could influence its presence using the t test and χ2 test. Results Spin assessment performed in the included 75 RCTs revealed the existence of spin in 23 abstracts (30.7%). Associations between the presence of spin in abstracts and the variables international collaborations, commercial support type, number of treatment arms, and journal impact factor were found to be statistically nonsignificant (P ≥ .05). Conclusions Approximately one-third of the 75 RCT abstracts published in high-impact dental journals in 2015 with nonsignificant outcomes presented with some form of spin, irrespective of funding type and journal impact factor. Practical Implications Clinicians should be aware of the potential existence of spin in abstracts and be diligent in reading and appraising the full trial before incorporating its recommendations in clinical practice.

Oral Diseases (2012) 18, 625–632 Non-exposed bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a newly reported complication arising from bisphosphonate therapy that presents with atypical symptoms and no apparent mucosal fenestration or exposure of necrotic bone. The clinical observation of the presence of necrotic bone underneath normal epithelial coverage was not conclusive for the diagnosis of BRONJ based on current guidelines established by the American Association of Oral and Maxillofacial Surgeons (AAOMS) and the American Society for Bone and Mineral Research (ASBMR), which specify the presence of clinically exposed necrotic bone for more than 8 weeks. Hence, the purpose of this review is to critically assess the current guidelines for diagnosis and management of BRONJ and propose a modified staging system and treatment guidelines to properly address the non-exposed variant of BRONJ lesions.

Microbial biofilms have been observed and described in bone specimens of patients with bisphosphonate (BP)-associated osteonecrosis of the jaw (BONJ) and investigators are more recently suggesting that this condition essentially represents an osteomyelitis of the jaw clinically, with greater susceptibility in some patients on BP therapy. This article explains the role of microbial biofilms in BONJ and also discusses associated factors in the disease pathogenesis, which include BP effects on bone remodeling, anti-angiogenesis, matrix necrosis, microcracks, soft tissue toxicity, and inflammation and wound healing. Recent findings suggest a key role for microbial biofilms in the pathogenesis of BONJ; this has important therapeutic implications because biofilm organisms represent a clinical target for prevention and treatment efforts aimed at reducing the significant morbidity and costs associated with this condition.

Epidemiologic studies on sleep disorders in the USA have mostly focused on specific disorders in specific groups of individuals. Most studies on sleep habits and sleep-related difficulties have focused on children and adolescents. The authors describe the prevalence of the three common physician-diagnosed sleep disorders (insomnia, sleep apnea, and restless legs syndrome (RLS)) by age, gender, and race in the US population. In addition, the authors describe the sleep habits and sleep-related difficulties in carrying routine daily activities. The authors also investigate the impact of the sleep disorders on performing routine daily activities.Data from the 2005-2006 National Health and Nutrition Examination Survey for 6,139 individuals over the age of 16 was analyzed for sleep-related parameters.The prevalence was highest for sleep apnea (4.2%), followed by insomnia (1.2%) and RLS (0.4%). Hispanics and Whites reported longer sleep duration than Blacks by 24 to 30 min. The predominant sleep habits were snoring while sleeping (48%), feeling unrested during the day (26.5%), and not getting enough sleep (26%). Difficulty concentrating (25%) or remembering (18%) were the main sleep-related difficulties in our sample. Insomnia, sleep apnea, and RLS had the highest impact on concentration and memory.Our findings suggest that the prevalence of sleep disorders in the USA is much lower than previously reported in the literature suggesting under diagnosis of sleep disorders by primary care physicians.

Background Saliva is being studied extensively and is being used for risk assessment, diagnosis and monitoring high-risk behavior and disease progression. A variety of medical conditions and medications are associated with salivary gland hypofunction. The major disadvantage in the use of saliva for health-related purposes is the lack of standardization in saliva collection methods. Methods The authors provide a brief overview of different methods of saliva collection and the advantages and disadvantages associated with each method, as well as of how to assess the salivary flow rate. Results The authors present the complete set up and step-by-step guidelines for the collection of unstimulated and stimulated whole saliva. Conclusions The life expectancy of people will continue to increase with advances in medicine and therapeutic modalities, and the prevalence of salivary gland hypofunction in the elderly population will increase owing to their longevity. The assessment of salivary gland hypo-function will need to be incorporated into everyday clinical practice. Clinical Implications The saliva collection methods outlined in this article can be used by dentists to assess patients at risk of developing diseases and by scientists for scholarly activities.

Objective. The aim of this report was to examine the oral cancer incidence by sex, race/ethnicity, and anatomical subsite. Study design. Data from the California Cancer Registry (CCR) were used to calculate the age-adjusted incidence rates of invasive oral squamous cell carcinoma (OSCC) by sex, race/ethnicity, and anatomical subsite among residents in California during 1988 to 2001. Results. Although non-Hispanic (NH) black men have the highest overall incidence rate for OSCC, NH whites and NH blacks have similar incidence patterns by subsite, but the male-to-female (M:F) rate ratio is higher among NH blacks. The OSCC incidence rates for Hispanics are much lower than those for NH whites and NH blacks and similar to those of Asians. The Asian ethnic groups display dramatic variations in terms of the subsite-specific incidence rates and M:F rate ratios. Conclusion. The findings illustrate the heterogeneity and complexity of oral cancer by anatomical location and the importance of cultural habits and behavioral factors in the development of oral cancer. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105:470-80)

Background Toxic epidermal necrolysis (TEN) is a rare and potentially fatal adverse dermatologic reaction, often secondary to drug intake. Methods and results We report a case of an adult male who developed TEN that was complicated by a sepsis-induced coma lasting a period of 3 months. Although the patient eventually recovered, severe oral mucosal involvement during the course of disease resulted in frenum-like fibrotic bands that connected movable oral mucosa (tongue and lips) to attached oral mucosa (gingiva). This complication was painful and also affected his ability to speak and maintain adequate oral hygiene, requiring surgical intervention to restore structure and function. Conclusions This oral manifestation in relation to TEN is rarely reported in the literature and represents a preventable complication.

Oral mucosal melanoma (OMM) is an extremely rare malignancy, accounting for < 0.5% of all melanomas and all oral malignancies. The rarity of OMM, the heterogeneity in clinical and histopathologic appearances, and the paucity of molecular and genetic studies to date have limited our knowledge of the etiopathogenesis of these cancers. A 39-year-old Hispanic male presented for evaluation of a large, pigmented, plaque-like and nodular growth of the maxillary gingival and palatal mucosa. On presentation, a presumptive clinical diagnosis of mucosal melanoma was made, which was confirmed by incisional biopsy with subsequent histopathologic evaluation. Macroscopically, the morphology and highly pigmented nature of the tumor was suggestive of a rarer subtype of melanoma known as animal-type melanoma, also referred to as pigmented epithelioid melanocytoma. However, microscopically, the tumor showed histopathologic features consistent with a high-grade acral (mucosal) lentiginous melanoma with overt cytomorphologic features of malignancy in addition to showing prominent pigment synthesis resembling animal-type melanoma. A detailed search of the literature did not identify a previous report of OMM with prominent pigment synthesis resembling animal-type melanoma. Identification of melanoma subtypes has specific implications for therapeutic approach, and thus their recognition is important to successful patient management.

Purpose Biofilm theory has emerged to explain the etiology of the chronic infections that have come to constitute between 65% to 80% of the microbial diseases treated by physicians in the developed world. The purpose of this article is to report for the first time the observation of multispecies microbial biofilms on affected bone in patients with osteonecrosis of the jaws (ONJ) secondary to bisphosphonate therapy. Patients and Methods A program has been established at the University of Southern California to monitor and evaluate patients with ONJ as a multidisciplinary collaboration between the School of Dentistry, Center for Biofilms, Center for Craniofacial Molecular Biology and the Keck School of Medicine. From this cohort, 4 patients with active ONJ who were scheduled for necessary treatment in the form of sequestrectomy gave informed consent for this study. Bone samples were evaluated using conventional histopathologic techniques and scanning electron microscopy, a technique applicable to biofilm characterization. Results Bone specimens from affected sites in all patients showed large areas occluded with biofilms comprising mainly bacteria, and occasionally yeast, embedded in extracellular polymeric substance. The number of bacterial morphotypes in the biofilms ranged from 2 to 15, and they included species from the genus Fusobacterium , bacillus, actinomyces, staphylococcus, streptococcus, Selenomonas , and 3 different types of treponemes. The yeast identified was consistent with Candida species. Co-aggregation was observed between different species within the biofilms. Conclusion These findings have important clinical and therapeutic implications and may suggest a role for microbial biofilms in the disease process of ONJ.

Aim The objective of this report is to present the clinical experiences of several patients affected with osteonecrosis (ONJ) secondary to bisphosphonate (BP) therapy and to provide a discussion of the specific BPs implicated in this condition. Background ONJ secondary to BP therapy is becoming an increasingly reported complication following dental therapy. This is particularly true of surgical dental procedures such as extractions. BPs are a class of pharmaceuticals used in the treatment of numerous disorders affecting bone, including osteoporosis, cancer metastases to bone, hypercalcemia of malignancy, and multiple myeloma. Although ONJ is a more recently described phenomenon, it is an emerging problem that may be associated with significant morbidity such as oral dysfunction, impaired eating ability, pain, and compromised esthetics resulting in a poor quality of life in affected patients. Case Report This is a description of 13 patients affected with ONJ secondary to BP therapy managed at the Orofacial Pain & Oral Medicine Center, Special Patients Clinic, and Oral and Maxillofacial Surgery Clinic at the University of Southern California, School of Dentistry between October 2005 and April 2007, with a discussion of the specific BPs implicated in this condition, the clinical presentation, management, and follow-up. Summary Thorough reporting of every case of ONJ is important to help advance the understanding of this poorly understood condition. The authors’ approach to care represents a more conservative mode to management than previously described by many investigators. Citation Kumar SKS, Meru MC, Sedghizadeh PP. Osteonecrosis of the Jaws Secondary to Bisphosphonate Therapy: A Case Series. J Contemp Dent Pract 2008 January;(9)1:063-069.

Peripheral ossifying fibroma (POF) is a common solitary gingival growth thought to arise from the periodontal ligament. Though the etiology of POF remains unknown, some investigators consider it an inflammatory or reactive process, while others suggest it is a neoplastic process. In this report, we present and discuss a unique case of multicentric POF, affecting the maxillary and mandibular gingiva of a 49-year-old Caucasian female with meticulous oral hygiene and routine dental care. Though biopsy samples from multiple sites revealed similar histopathologic features, consistent with POF, the fact that there was a multicentric presentation is a unique phenomenon for this lesion. Multicentric lesions presenting in the oral and maxillofacial region are not typical, but have been observed in conditions associated with known genetic mutations, such as nevoid basal cell carcinoma syndrome (multiple odontogenic keratocysts), multiple endocrine neoplasia type II (multiple neuromas), neurofibromatosis (multiple neurofibromas) and Gardner syndrome (multiple neoplasms). This case is the first one to demonstrate that there may be a multicentric variant of POF that has not been previously recognized, and given the clinical presentation and multifocal nature of disease, the lesions in this patient are likely the result of genetic mutation(s) that predisposes to gingival soft tissue overgrowths containing mineralized product.

JADA 143(10) http://jada.ada.org October 2012 e67 CLINICAL PROBLEM A 50-year-old man visited his dentist’s office with moderate jaw pain on both sides of his face that began about two months previously. He reported that the pain was most severe on awakening. He reported clenching and grinding his teeth at night and believed that this might be contributing to his jaw pain. The patient stated that his wife also had observed him grinding and clenching his teeth during sleep, and she told him that she believed it had become progressively more severe in the recent past. The patient’s medical history was significant for hypertension and depression, and his medications included propranolol, hydrochlorothiazide and fluoxetine. On clinical examination, the patient reported experiencing moderate pain on palpation in both masseter muscles and both temporalis muscles.

Systematic review conclusion. Extraoral endodontic treatment is not detrimental for avulsed permanent teeth that are replanted after more than 60 minutes' dry time. Other treatments require more study. Critical summary assessment. Although all experimental interventions for avulsion included in this systematic review showed favorable outcomes, conclusions must be interpreted with caution owing to a moderate-to-high risk of bias in all the studies included in the review. Evidence quality rating. Limited.

Bisphosphonate (BP) drugs are a commonly prescribed group of medications used in the treatment of metabolic and oncologic bone disorders. The aim of this study was to conduct a systematic review in order to evaluate whether patients on BP therapy are appropriate candidates for dental implants as compared to patients not taking BP drugs with respect to successful implant osseointegration and the risk of developing bisphosphonate-related osteonecrosis of the jaw. Based on the current literature, a history of oral or intravenous BP use is not an absolute contraindication for dental implant placement, and dental implants can osseointegrate successfully in this patient population. Importantly, the studies currently available on this topic are of moderate to weak strength of evidence with inherent bias and limitations, and hence results must be interpreted in this context. Well-controlled studies with higher strength of evidence and larger population sizes are required to address this topic more accurately in the future.

Chronic orofacial pain is a rapidly evolving and challenging field that deals with the management of pain originating from neurogenic, osseous, muscular, or vascular structures of the head and neck. The challenge lies in the accurate diagnosis of orofacial pain conditions, which may be difficult to differentiate in many clinical situations. As pain cannot be "seen" or precisely located or its intensity measured with any device, clinicians must rely heavily on the patient's own description of type, duration and location of pain, and thus, history plays a crucial role in diagnosis. Advances in neuroscience, pharmacology, and pain management have made medications one of the primary therapeutic modalities in the management of pain including orofacial pain conditions. Despite this, these medications will not help patients if the origin and nature of pain is not accurately diagnosed. Hence, diagnosis is critical for successful management of orofacial pain conditions. Experience and knowledge of practice in pain management have led clinicians to devise several clinical diagnostic tests using medications in various forms (topical, oral, injections, intravenous infusions) to differentiate certain orofacial pain disorders where the nature of pain is unclear and the presentation of pain is at multiple sites. Although the diagnostic tests are not 100 percent accurate, they are very effective in many clinical scenarios, especially in orofacial pain conditions. Topical medications such as anesthetics and anti-inflammatories, oral medications such as anti-inflammatory drugs and skeletal muscle relaxants, injections such as local anesthetics and corticosteroids, and vapocoolant sprays are some examples of the modalities used by clinicians to manage orofacial pain conditions. These medications may also be used for diagnostic tests to aid in accurate diagnosis of some orofacial pain conditions. In addition, there are special cases where medications such as triptans, carbamazepine and indomethacin may be used as diagnostic tests to confirm diagnosis of migraines, neuralgias, or stabbing headaches, respectively. Based on the concept of using medications to predict which treatment would be best for certain pain conditions or to aid in better diagnosis, diagnostic intravenous infusions of lidocaine, morphine, and ketamine have been studied to test the response to adjuvant analgesics and oral dextromethorphan. Paradoxically, taking the patients off their current medications can be of diagnostic significance in conditions like medication overuse headache and serotonin selective reuptake inhibitor-induced clenching. In summary, this paper focuses on the use of medications in different forms as useful diagnostic tests for differential diagnosis of orofacial pain conditions that are difficult to diagnose or are refractory to past or current treatment.

Background The authors report their observations with respect to microbial biofilms in osteomyelitis of the jaw (OMJ), compare these findings with those for osteonecrosis of the jaw (ONJ) secondary to bisphosphonate therapy and discuss recent findings that the pathogenesis of ONJ may represent a biofilm-mediated infectious disease in the context of bisphosphonate therapy. Methods In 2004, a program was established at the University of Southern California, Los Angeles, to evaluate, treat and monitor patients who have OMJ and ONJ. Twenty people from this cohort of study patients who were scheduled to undergo surgical debridement or sequestrectomy and who met the authors' inclusion criteria gave informed consent for the study. The authors examined bone samples histopathologically and via scanning electron microscopy, a technique applicable to biofilm characterization. Results Specimens from all patients with OMJ and ONJ exhibited large surface areas of bone occluded with well-developed biofilms comprising microbial organisms embedded in an extracellular polymeric substance. Actinomyces predominated in OMJ cases, whereas ONJ cases represented more diverse bacterial organisms in addition to fungal organisms not seen in OMJ. The authors observed resorption pits, septic clots, putative nanowires and host inflammatory cells in all specimens. Conclusions The findings of this study support a role for microbial biofilms in both disease processes. Clinical Implications Microbial biofilms are a potential target for therapy that includes antibiofilm modalities in the treatment and prevention of OMJ and ONJ.

A 58-year-old woman visited the emergency department at the University of Southern California (USC) School of Dentistry, Los Angeles, with a chief complaint of a sore and swollen tongue. The emergency department clinician referred her immediately to the Orofacial Pain and Oral Medicine Center, USC School of Dentistry, for further evaluation and treatment. The patient reported having first noticed the lesion on her tongue 10 days earlier. The lesion increased in size during the next few days. She could not recall having experienced any trauma to her tongue before the onset of the lesion and denied any history of similar lesions. She had been taking over-the-counter acetaminophen for pain and cephalexin, an oral antibiotic that her physician prescribed, neither of which improved the lesion. Her medical history was unremarkable, and she was not taking any medications other than those for the tongue lesion. The patient reported having allergies to penicillin and codeine. She denied any current or previous tobacco use in any form, and she reported drinking alcohol occasionally. One of us (S.K.S.K.) performed an extraoral examination, which revealed no abnormalities or lymphadenopathy. The intraoral examination revealed an exophytic, erythematous swelling on the right dorsal surface of the anterior tongue. The lesion had an ovoid central ulceration measuring about 1 centimeter in diameter, which was covered by a yellow-white fibrinouslike membrane. On palpation, the lesion was indurated (Figure 1). To reach a definitive diagnosis, the clinician (S.K.S.K.) performed an incisional biopsy while the patient was under local anesthesia. The lesion began to regress spontaneously within one week after the incisional biopsy (Figure 2). Within three weeks, it was almost completely healed (Figure 3). The histologic examination ruled out a malignancy. Indurated tongue lesion

Lichen planus, a chronic autoimmune, mucocutaneous disease affects the oral mucosa (oral lichen planus or OLP) besides the skin, genital mucosa, scalp and nails. An immune mediated pathogenesis is recognized in lichen planus although the exact etiology is unknown. The disease most commonly affects middle-aged females. Oral lichenoid reactions (OLR) which are considered variants of OLP, may be regarded as a disease by itself or as an exacerbation of an existing OLP, by the presence of medication (lichenoid drug reactions) or dental materials (contact hypersensitivity). OLP usually presents as white striations (Wickham's striae), white papules, white plaque, erythema, erosions or blisters. Diagnosis of OLP is established either by clinical examination only or by clinical examination with histopathologic confirmation. Direct immunofluorescence examination is only used as an adjunct to the above method of diagnosis and to rule out specific autoimmune diseases such as pemphigus and pemphigoid. Histopathologic features of OLP and OLR are similar with suggestions of certain discriminatory features by some authors. Topical corticosteroids are the treatment of choice for OLP although several other medications have been studied including retinoids, tacrolimus, cyclosporine and photodynamic therapy. Certain OLP undergo malignant transformation and the exact incidence and mechanisms are still controversial. In this paper, etiopathogenesis, diagnosis, management and malignant transformation of OLP and OLR have been reviewed.

A scalable object location service can enable users to search for various objects in an environment where many small, networked devices are attached to objects. We investigate two hierarchical, self-configuring or unattended approaches for an efficient object location service. Each approach has its advantages and disadvantages based on the anticipated load. The first approach, SCOUT-AGG, is based on aggregation of object names. The second approach, SCOUT-MAP, is based on indirection, where information about an object is stored at the locator sensor for the object. The relative efficiency of SCOUT-AGG and SCOUT-MAP can be characterized by the query to mobility, update rate of the system. SCOUT-AGG performs better for low query to update rate but its performance deteriorates in general relative to SCOUT-MAP as the queries to update rate increases. The rate of performance deterioration depends on query specificity (i.e., queries for a specific object or for any object of a particular type). SCOUT-MAP generally exhibits better load balancing than SCOUT-AGG for various scenarios. We support the above results through simple analytical modeling and simulation.

Systematic review conclusion. Mouthrinses containing antibacterial agents (chlorhexidine and cetylpyridinium chloride) or those containing chlorine dioxide and zinc can reduce halitosis to some extent. Critical summary assessment. Although antibacterial mouthrinses can reduce halitosis, the extent of effectiveness is uncertain owing to incomplete reporting, possible study bias and variation in patients' characteristics and assessment methods. Evidence quality rating. Limited.

Networked sensors-those that coordinate amongst themselves to achieve a larger sensing task-will revolutionize information gathering and processing both in urban environments and in inhospitable terrain. The sheer numbers of these sensors and the expected dynamics in these environments present unique challenges in the design of unattended autonomous sensor networks. These challenges lead us to hypothesize that sensor network coordination applications may need to be structured differently from traditional network applications. In particular, we believe that localized algorithms (in which simple local node behavior achieves a desired global objective) may be necessary for sensor network coordination. In this paper, we describe localized algorithms, and then discuss directed diffusion, a simple communication model for describing localized algorithms.

Multicast routing enables efficient data distribution to multiple recipients. However, existing work has concentrated on extending single-domain techniques to wide-area networks, rather than providing mechanisms to realize inter-domain multicast on a global scale in the Internet.We describe an architecture for inter-domain multicast routing that consists of two complementary protocols. The Multicast Address-Set Claim (MASC) protocol forms the basis for a hierarchical address allocation architecture. It dynamically allocates to domains multicast address ranges from which groups initiated in the domain get their multicast addresses. The Border-Gateway Multicast Protocol (BGMP), run by the border routers of a domain, constructs inter-domain bidirectional shared trees, while allowing any existing multicast routing protocol to be used within individual domains. The resulting shared tree for a group is rooted at the domain whose address range covers the group's address; this domain is typically the group initiator's domain. We demonstrate the feasibility and performance of these complementary protocols through simulation.This architecture, together with existing protocols operating within each domain, is intended as a framework in which to solve the problems facing the current multicast addressing and routing infrastructure.

It is unclear whether hypertension (HTN) is a predisposing factor for the development of trigeminal neuralgia (TN). The purpose of this study was to determine the prevalence of HTN in TN patients and controls at the USC Orofacial Pain and Oral Medicine Center. A retrospective chart review was conducted from a database of over 3,000 patient records from 2003 to 2007. We identified patients diagnosed with TN with or without HTN. A total of 84 patients (54 females; 30 males) between the ages of 33 and 93 years were diagnosed with TN; 37% had TN with HTN and 32% of controls had HTN. The increased prevalence of HTN in the TN patients was not statistically significant (P = 0.50). Since, both TN and HTN are seen in the elderly, it is likely that HTN is simply a co-existing condition in patients with TN and not a risk factor for its development.