47 results on '"Sancakdar E."'
Search Results
2. Poster session Thursday 12 December - AM: 12/12/2013, 08: 30–12: 30Location: Poster area
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Karapinar, H, Kaya, A, Uysal, EB, Guven, AS, Kucukdurmaz, Z, Oflaz, MB, Deveci, K, Sancakdar, E, Gul, I, and Yilmaz, A
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- 2013
3. Increased levels of VEGF-A and HIF-1? in Turkish children with crimean-congo hemorrhagic fever
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Sefikogullari M., Kaya A., Aydin H., Sancakdar E., Celik V.K., Bagci G., and Sefikogullari, M., Pediatric Clinic, Private Samandağ Medical Center, Hatay, Turkey -- Kaya, A., Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Aydin, H., Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Sancakdar, E., Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Celik, V.K., Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Bagci, G., Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey
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Sepsis ,HIF-1? ,Crimean Congo Hemorrhagic Fever ,Children ,VEGF - Abstract
Background: Crimean-Congo Hemorrhagic Fever (CCHF) is a disease characterized by serious course, including acute viral fever, ecchymosis, thrombocytopenia, liver dysfunction and high rate of mortality. Hypoxia Inducible Factor-1a (HIF-1?) and Vascular Endothelial Growth Factor-A (VEGF-A) play an important role both in the inflammatory process and plasma leakage. The aim of this study was to define HIF-1? and VEGF-A serum levels obtained from CCHF patients and control group and to investigate whether these factors were correlated with the pathogenesis of this disease. Methods: Thirty cases younger than 17 yr confirmed by RT-PCR and/or ELISA for CCHF were included in this study. Thirty age and sex matched healthy peoples were enrolled as controls. Blood samples collected from the patient and control groups. Serum levels of HIF-1? and VEGF-A were measured with ELISA. Results: Levels of HIF-1? and VEGF-A were statistically significantly increased in CCHF patients compared to the control group (P < 0.05). A significant positive correlation was found between the levels of HIF-1? and VEGF-A in the patient group (P < 0.01). The levels of ALT, AST, CK, aPTT, WBC and Thrombocyte count were significantly higher in the patients than in the control group (P < 0.001). A positive correlation was found among the levels of AST and CK from biochemical parameters and VEGF and HIF-1? in the patient group (P 0.05) Conclusion: HIF-1? and VEGF-A might play an important role in CCHF pathogenesis.
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- 2017
4. Role of adducin gly460trp, ACE I/D and AGT M235T gene polymorphisms in genetic susceptibility to diabetic nephropathy [Diyabetik nefropatiye eğilimde adducin gly4460trp, Ace I/D and agt M235t gen polimorfizmlerinin rolü]
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Sancakdar E., Ateş K., Kaman D., Deveci K., Özkan Y., İlhan N., and Sancakdar, E., Departments of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey -- Ateş, K., Orhangazi State Hospital, Central Laboratory, Bursa, Turkey -- Kaman, D., Departments of Biochemistry, Firat University School of Medicine, Elazig, Turkey -- Deveci, K., Departments of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey -- Özkan, Y., Department of Internal Medicine, Firat University School of Medicine, Elazig, Turkey -- İlhan, N., Departments of Biochemistry, Firat University School of Medicine, Elazig, Turkey
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DM ,Diabetic nephropathy ,ACE I/D polymorphism ,ADD G460W polymorphism ,AGT M235T polymorphism - Abstract
TIP ARASTIRMALARI DERNEGI, Diabetes mellitus is a metabolic disease with a high incidence of morbidity and mortality lowering the quality of life with acute and chronic complications and it needs to be followed up and treated throughout the lifespan. Concordant with the frequency of DM and the increase in the length of life frequency of DNP is also increased. The I allele of the ACE I/D polymorphism, AGT M235T’s T allele and ADD G460W’s W allele presence are purported to present a predisposition to DNP. In our study we aimed to investigate the effect of the AGT M235T, ACE I/D and ADD 460W polymorphisms in the development of DNP in patients with diabetes mellitus. The study group consisted of 194 patients with Diabetic nephropathy and the control group contained 100 DM patients. In the diabetic group the DD genotype of the ACE I/D polymorphism was 54 (54.0%) and the D allele was 69.0% and in the nephropathy group II genotype of the ID were 78 (40.2%) and 51 (26.3%) and the I allele was 46.4 respectively and the presence of the I allele was associated with the presence of nephropathy. There was no significance between the genotypes in the presence of a coexistence of AGT M235T and ACE I/D polymorphisms between the groups the MD alleles (42%) demonstrated significance in the diabetic and the T/I alleles (28.1) demonstrated significance in the nephropathy group. In the ADD G640W polymorphism on its own, subjects having GG (77.3%) and WW (7.7%) genotypes (p=0.025) might have been predisposed to nephropathy however when in combination with the ACE I/D, the presence of the DD/GG (45%) in the diabetic group and the presence of the ID/GG (29.9%) and II/GG (19.6%) combination in the DNP group were statistically significant. The D/G (64%) alleles were significant in the diabetic and the I/G (36.6) alleles were significant in the DNP groups respectively. As a conclusion we think that the II-ID/GG genotype and the I/G alleles in the presence of the ACE-ADD combination and TT/ID genotype and T/I alleles in the ACE-AGT combination may be effective in the predisposition of the diabetic patients to nephropathy. © 2015, TIP ARASTIRMALARI DERNEGI. All rights reserved., Sancakdar, E.; Contact information, Departments of Biochemistry, Cumhuriyet University School of MedicineTurkey
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- 2015
5. Vitamin D status in children with Crimean-Congo hemorrhagic fever
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Uysal, E. B., Nevin Tuzcu, Sancakdar, E., Güven, A. S., Akkar, I., Deveci, K., Kaya, A., and [Uysal, E. B.] Cumhuriyet Univ, Dept Microbiol, TR-58140 Sivas, Turkey -- [Tuzcu, N.] Cumhuriyet Univ, Dept Pharmaceut Microbiol, TR-58140 Sivas, Turkey -- [Sancakdar, E. -- Deveci, K.] Cumhuriyet Univ, Dept Biochem, TR-58140 Sivas, Turkey -- [Guven, A. S. -- Akkar, I. -- Kaya, A.] Cumhuriyet Univ, Dept Pediat, TR-58140 Sivas, Turkey
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Crimean-Congo hemorrhagic fever ,lcsh:RC109-216 ,vitamin D ,Children ,immune response ,infection ,lcsh:Infectious and parasitic diseases - Abstract
WOS: 000355242400005, PubMed ID: 25815865, Background & objectives: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease, causing severe viral hemorrhagic fever outbreaks. This study aimed at determining the serum vitamin D levels and investigated the association between Crimean-Congo hemorrhagic fever (CCHF) and serum vitamin D levels in children with CCHF. Methods: A total of 45 children aged between 5 and 15 yr, viz. 15 healthy control (HC) and 30 pediatric patients diagnosed with CCHF with real-time polymerase chain reaction (PCR) (patient group) were selected for the study. Results: Analysis of the blood serum samples taken from the said individuals revealed that vitamin D, parathyroid hormone and calcium levels of the patients and the control groups were statistically different. Interpretation & conclusion: It was found that the serum vitamin D levels of the pediatric patients with CCHF were lower when compared to those of the controls, and that a low vitamin D level could negatively affect the reaction of the body to infections in children having CCHF.
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- 2015
6. The prevalence of anemia among children aged 1-15 admitted to hospital in sivas [Sivas İlinde Hastaneye Başvuran 1-15 Yaş Grubu Çocuklar Arasında Anemi Prevalansı]
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Karagün B.Ş., Korkmaz Ö., Gürsu A.H., Cevit Ö., Solmaz S., Bayram B., Aslan E., Sancakdar E., Cevit R., Özkan F., Özsoy İ.E., and Karagün, B.Ş., Sivas Numune Hastanesi, Pediatrik Hematoloji Kliniği, Sivas, Turkey -- Korkmaz, Ö., Sivas Numune Hastanesi, Pediatrik Endokrinoloji Kliniği, Sivas, Turkey -- Gürsu, A.H., Sivas Numune Hastanesi, Pediatrik Kardiyoloji Kliniği, Sivas, Turkey -- Cevit, Ö., Sivas Cumhuriyet Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Sivas, Turkey -- Solmaz, S., Sivas Numune Hastanesi, Hematoloji Kliniği, Sivas, Turkey -- Bayram, B., Sivas Numune Hastanesi, Çocuk Sağlığı ve Hastalıkları Kliniği, Sivas, Turkey -- Aslan, E., Sivas Halk Sağlığı Müdürlüğü, Sivas, Turkey -- Sancakdar, E., Sivas Cumhuriyet Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı, Sivas, Turkey -- Cevit, R., Sivas Numune Hastanesi, Patoloji Bölümü, Sivas, Turkey -- Özkan, F., Sivas Numune Hastanesi, Anestezi Bölümü, Sivas, Turkey -- Özsoy, İ.E., Sağlık Bakanlığı, Sivas, Turkey
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Child health ,Hypochromic ,Diagnosis ,Anemia ,Frequency - Abstract
Galenos Yayincilik, Introduction: In this study, we aimed to determine the incidence of anemia in children between the ages of 1-15. Materials and Methods: A total of 14449 patients admitted to pediatric outpatient clinic between 01.01.2012 and 31.12.2012 were retrospectively reviewed from hospital records. Patients between the ages of 1-15 without chronic disease were included into the study in order to evaluate the prevalence of anemia. Results: Of patients admitted to hospital, 8747 were male (60.5%) and 5707 were female (39.5%). Patients were divided into five groups according to age groups including, 2531 patients in 1-3 age group (17.5%), 2872 patients in 4-6 age group (19.9%), 2735 patients in 7-9 age group (18.9%), 2637 patiens in 10-12 age group (18.3%) and 3674 patients in 13-15 age group (25.4%). Anemia was detected in 853 (5.9%) patients, and 465 of them were male (54.5%) and 388 of them were female (45.5%). The distrubition of anemia according to age group was as follows: 205 patients in 1-3 age group (8.1%), 97 in 4-6 age group (3.4%), 98 in 7-9 age group (3.6%), 128 in 10-12 age group (4.9%) and 325 in 13-15 age group (8.9%). The distribution of low MCV values according to age groups was as follows: 1-3 age group; 9.4% (237), 4-6 age group; 5.3% (151), 7-9 age group; 3.8% (104), 10-12 age group; 4.5% (119), 13-15 age group; 8.0% (294). Conclusions: Anemia is one of the most common diseases in the pediatric age group. Anemia continues to be a major health problem in childhood in spite of the policies of the health in our country. Diagnosis and treatment is easy. Physicians should be alert to anemia in childhood and families should be informed about this topic. Also all society must work to improve this situation which affects the health and mental development. © The Journal of Current Pediatrics, published by Galenos Publishing., Karagün, B.Ş.; Çukurova Üniversitesi Tıp Fakültesi, Balcalı Hastanesi, Çocuk Hematoloji Bilim DalıTurkey
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- 2014
7. Evaluation of complement system in children with Crimean-Congo hemorrhagic fever
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Sancakdar, E., Uysal, E. B., Guven, A. S., Kaya, A., Filiz, A. K., Acibucu, D. O., Deveci, K., Seker, M. M., and [Sancakdar, E. -- Acibucu, D. O. -- Deveci, K.] Cumhuriyet Univ, Fac Med, Dept Biochem, Sivas, Turkey -- [Uysal, E. B.] Cumhuriyet Univ Med, Dept Clin Microbiol, Sivas, Turkey -- [Guven, A. S. -- Kaya, A.] Cumhuriyet Univ, Fac Med, Dept Pediat, Sivas, Turkey -- [Filiz, A. K.] Cumhuriyet Univ, Fac Med, Dept Physiol, Sivas, Turkey -- [Seker, M. M.] Cumhuriyet Univ, Fac Med, Dept Med Oncol, Sivas, Turkey
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Complement 4 ,Complement 3 ,Crimean-Congo haemorrhagic fever ,Bb - Abstract
WOS: 000341967900010, PubMed ID: 24668707, OBJECTIVES: The complement system participates in the defense of the body against viral infections through various mechanisms. In the present study conducted on children having Crimean-Congo Hemorrhagic Fever (CCHF), the aim was to evaluate whether the complement system had a role in the pathogenesis of the disease. PATIENTS AND METHODS: Forty-one patients diagnosed with CCHF and 32 healthy controls were included in the study. Serum complement component 3 (C3), 4 (C4) and complement product Bb (Bb) levels were measured in both groups. RESULTS: Compared to the control group, serum C3 levels were lower and Bb levels were higher in CCHF patients (p < 0.01). Moreover, in the patient group, C3 levels were positively correlated with WBC and PLT counts, and Bb levels were positively correlated with AST, ALT and LDH activities. In the patient group, serum Bb levels were negatively correlated with WBC and PLT counts. CONCLUSIONS: The results of the present study suggest that increased activity of the alternative pathway of the complement system in children with CCHF may have a role in the pathogenesis of the disease., Research Foundation Council of Cumhuriyet University [T-534], This study is partly supported by Research Foundation Council of Cumhuriyet University (Project No. T-534).
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- 2014
8. Cystatin C in serum as an early marker of renal involvement in Familial Mediterranean Fever patients
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Senel, S., Deveci, Hülya, Deveci, K., Gokakin, A. K., Uslu, A. U., Sancakdar, E., and [Deveci, K. -- Sancakdar, E.] Cumhuriyet Univ, Sch Med, Dept Clin Biochem, Sivas, Turkey -- [Gokakin, A. K.] Cumhuriyet Univ, Sch Med, Dept Gen Surg, Sivas, Turkey -- [Senel, S.] Cumhuriyet Univ, Sch Med, Dept Internal Med, Sivas, Turkey -- [Deveci, H.] Erciyes Univ, Sch Med, Dept Rheumatol, Kayseri, Turkey -- [Uslu, A. U.] Numune State Hosp, Dept Phys Med & Rehabil, Sivas, Turkey
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urogenital system ,Familial mediterranean fever ,Amyloidosis ,Cystatin C ,urologic and male genital diseases - Abstract
WOS: 000319224700017, PubMed ID: 23377817, BACKGROUND: The major renal involvement in Familial Mediterranean Fever (FMF) is the occurrence of amyloidosis that primarily affects the kidneys manifested by proteinuria and ending in death from renal failure. AIM: This study aims to investigate whether serum cystatin (cys-C) levels could be used as an early marker of renal involvement in FMF patients. PATIENTS AND METHODS: Forty-six patients with FMF during the attack period (AP), and 41 patients with FMF during attack-free periods (AFP), and 11 patients with FMF associated amyloidosis, and 38 healthy controls were enrolled in the study. We determined cys-C levels in the serum of FMF patients and healthy controls. RESULTS: Serum cys-C levels were significantly increased in patients with FMF and secondary amyloidosis, and serum cys-C is a more accurate and efficient marker for detecting renal involvement than estimated glomerular filtration rate (e-GFR) in patients with FMF. CONCLUSIONS: We propose a cutoff level of the serum cys-C of 876.5 pg/mL for screening renal involvement in patients with FMF, and amyloidosis should be strongly suspected when the serum cys-C reaches 1565.5 pg/mL., Research Foundation Council of Cumhuriyet University [T-478], The Research Foundation Council of Cumhuriyet University partly supported this study (Project No. T-478). The Authors declare no other financial interests relevant to the present study.
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- 2013
9. Neutrophil gelatinase-associated lipocalin in platin induced renal injury
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Seker, M., Deveci, K., Sancakdar, E., Yilmaz, A. L. I., Turesin, A., Kacan, T., Babacan, N., and [Seker, M. -- Deveci, K. -- Sancakdar, E. -- Yilmaz, A. L. I. -- Turesin, A. -- Kacan, T. -- Babacan, N.] Cumhuriyet Univ, Fac Med, Sivas, Turkey
- Abstract
European Cancer Congress 2013 - 17th ECCO / 38th ESMO / 32nd ESTRO -- SEP 27-OCT 01, 2013 -- Amsterdam, NETHERLANDS, WOS: 000326843601206, …, European Conf Clin Oncol, European Soc Therapeut Radiol & Oncol, European Soc Med Oncol, European Soc Surg Oncol, European Assoc Canc Res, European Oncol Nursing Soc, European Soc Paediat Oncol
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- 2013
10. Alterations of serum brain type natriuretic peptide (BNP) in patients with Crimean-Congo hemorrhagic fever
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Uysal, E. B., Sancakdar, E., Şeker, A., Deveci, K., Nevin Tuzcu, Karapınar, H., and [Uysal, Elif Bilge] Cumhuriyet Univ, Fac Med, Dept Microbiol, TR-58140 Sivas, Turkey -- [Sancakdar, Enver -- Deveci, Koksal] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkey -- [Karapinar, Hekim] Cumhuriyet Univ, Fac Med, Dept Cardiol, TR-58140 Sivas, Turkey -- [Seker, Ayse] Muhittin Altinok Family Hlth Ctr, Sivas, Turkey -- [Tuzcu, Nevin] Cumhuriyet Univ, Fac Pharm, Dept Pharmaceut Microbiol, TR-58140 Sivas, Turkey
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Crimean-Congo hemorrhagic fever ,cardiac damage ,brain type natriuretic peptide - Abstract
WOS: 000355306000151, PubMed ID: 25932235, Background: Crimean-Congo hemorrhagic fever (CCHF) is known to be associated with cardiac damage. Brain type natriuretic peptide (BNP) is secreted from stressed myocardium. Objectives: This study investigated that BNP levels in CCHF and its association with clinical course of disease. Methods: Consecutive CCHF diagnosis confirmed patients were enrolled to the study. Results of patients were compared with age-sex-matched healthy volunteers. Blood samples for BNP levels were collected from the patients during emergency room applications. Mortality, hospitalization duration and other disease severity predictors (thrombocyte count, hemoglobin, white blood cell count, alanine aminotransferase, aspartate aminotransferase, prothrombin time, lactate dehydrogenase, international normalized ratio, activated partial thromboplastin time) were recorded. These parameters' correlations with BNP levels were analyzed. Result: Forty-three CCHF patients and 28 control subjects recruited to the study. Groups were similar for age and gender. There was no mortality. Levels of BNP were found to be significantly higher in patients than control subjects (100.4 +/- 45.4 vs. 78.0 +/- 40.4, P=0.033). But BNP levels were not correlated with duration of hospitalization and disease severity predictors (P > 0.05). Conclusions: This study showed that BNP levels are modestly increased in CCHF but this increase does not correlated with disease severity predictors.
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- 2015
11. Serum 17-OH progesterone and free testosterone levels in women patients with Familial Mediterranean Fever: a pivotal study
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Deveci, K., Gokakin, A. K., Boztosun, A., Deveci, H., Senel, S., Uslu, A. U., Sancakdar, E., and [Deveci, K. -- Sancakdar, E.] Cumhuriyet Univ, Sch Med, Dept Biochem, Sivas, Turkey -- [Gokakin, A. K.] Cumhuriyet Univ, Sch Med, Dept Gen Surg, Sivas, Turkey -- [Boztosun, A.] Cumhuriyet Univ, Sch Med, Dept Obstet, Sivas, Turkey -- [Boztosun, A.] Cumhuriyet Univ, Sch Med, Dept Gynecol, Sivas, Turkey -- [Deveci, H.] Numune State Hosp, Dept Phys Med & Rehabil, Sivas, Turkey -- [Senel, S.] Erciyes Univ, Sch Med, Dept Rheumatol, Kayseri, Turkey -- [Uslu, A. U.] Cumhuriyet Univ, Sch Med, Dept Internal Med, Sivas, Turkey
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Bacterial peritonitis ,Peritoneal dialysis ,Fungal peritonitis - Abstract
WOS: 000319224700018, PubMed ID: 23377818, BACKGROUND: Familial Mediterranean Fever (FMF) is an autosomal recessive disease characterized by short lived, febrile serosae inflammatory attacks. FMF has various effects in multiple systems and organs. AIM: In the present study, our aim was to evaluate adrenal steroidogenesis in female FMF patients. PATIENTS AND METHODS: There were 71 women in the study including 41 women with FMF and 30 women as healthy control group (HC group). Of 41 FMF patients, twenty were evaluated in attack period (AP-FMF group) whereas 21 of them were evaluated in attack-free period (AFP-FMF group). In all subjects; serum free testosterone, 17-OHP levels as hormones, IL-1 beta, TNF-alpha, IL-6, IL-18 as proinflammatory cytokines, CRP, fibrinogen, white blood cell (WBC) counts, and erythrocyte sedimentation rate (ESR) as acute phase reactants were measured in samples of venous blood taken in the morning before breakfast. RESULTS: Serum 17-OHP levels in AP-FMF group and AFP-FMF group were higher than in HC group (p < 0.001). A positive correlation was detected between serum levels of 17-OHP and IL-1 beta in FMF patients (p = 0.006; r = 0.486). There was no difference between FMF patients and HC group in terms of free testosterone levels (p > 0.05). CONCLUSIONS: Our results showed an increase in 17-OHP levels in FMF patients. These results may indicate that, regardless to the attack period adrenal steroidogenesis could be affected negatively in FMF patients., Research Foundation Council of Cumhuriyet University [T-478], The Research Foundation Council of Cumhuriyet University partly supported this study (Project No. T-478). The Authors declare no other financial interests relevant to the present study.
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- 2012
12. Value of ABO blood group in predicting the severity of children with Crimean-Congo hemorrhagic fever
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Güven, A. S., Sancakdar, E., Kaya, A., Uysal, E. B., Mehmet Burhan Oflaz, Bolat, F., Karapinar, H., Koç, E., Icagasioglu, F. D., [Guven, Ahmet Sami -- Kaya, Ali -- Oflaz, Mehmet Burhan -- Bolat, Fatih -- Koc, Elif -- Icagasioglu, Fusun Dilara] Cumhuriyet Univ, Fac Med, Dept Pediat, TR-58140 Sivas, Turkey -- [Sancakdar, Enver] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkey -- [Uysal, Elif Bilge] Cumhuriyet Univ, Fac Med, Dept Microbiol, TR-58140 Sivas, Turkey -- [Karapinar, Hekim] Cumhuriyet Univ, Fac Med, Dept Cardiol, TR-58140 Sivas, Turkey, Oflaz, Mehmet Burhan -- 0000-0003-1515-4654, and İÇAĞASIOĞLU, DİLARA FÜSUN
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children ,CCHF ,Original Article ,disease severity ,bleeding ,blood groups - Abstract
WOS: 000333151800012, PubMed ID: 24600498, Purpose: The aim of this study was to assess the role of ABO blood groups in predicting disease severity and bleeding potential in children with Crimean-Congo hemorrhagic fever (CCHF). Methods: One hundred fifty-one hospitalized patients with CCHF were enrolled in this retrospective study. The patients were divided according to O- and non-O-(A, B and AB) blood groups (n=91 and n=60, respectively). They were also classified into two groups (severe and non-severe) based on disease severity (n=29 and n=122, respectively). Demographic characteristics, clinical findings, and hematologic and biochemical parameters of all patients were recorded on admission and discharge. Results: Although, in all cases, compared to the non-O blood group, the ratio of the blood group O was considerably higher (60% vs. 40%) and similarly so in severe cases (58.6% vs. 41.4%), this difference was not statistically significant (p>0.05). The aPTT at discharge and fever duration of the O-blood group were significantly higher than those of the non-O-blood group (p=0.042, p=0.034, respectively). The factor VIII level of the O-blood group was significantly lower than that of the non-O-blood group (p=0.040). Although the ratios of bleeding and severity were higher in the O-blood group compared to the other group, statistical significance was not reached (p>0.05). Conclusions: Consideration of the ABO blood group is important during diagnostic follow-up to assess the severity of CCHF. In clinical practice, pediatric CCHF patients with the O blood group need to be followed closely for tendency to bleed.
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- 2014
13. Vitamin D status in children with Crimean-Congo hemorrhagic fever
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Uysal, EB, primary, Tuzcu, N, additional, Sancakdar, E, additional, Güven, AS, additional, Akkar, I, additional, Deveci, K, additional, and Kaya, A, additional
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- 2015
- Full Text
- View/download PDF
14. Serum adiponectin, leptin, and interleukin 6 levels as adipocytokines in children with febrile seizures
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Güven, AS, primary, Icagasioglu, FD, additional, Duksal, F, additional, Sancakdar, E, additional, Alaygut, D, additional, Uysal, EB, additional, Akkar, İ, additional, Oflaz, MB, additional, and Kaya, A, additional
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- 2014
- Full Text
- View/download PDF
15. Poster presentations
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Aksu F, Topacoglu H, Arman C, Atac A, Tetik S, Hasanovic A, Kulenovic A, Mornjakovic Z, Pikula B, Sarac-Hadzihalilovic A, Voljevica A, Bamac B, Colak T, Alemdar M, Dundar G, Selekler M, Dincer O, Colak E, Ozbek A, Kilic C, Kamburoglu K, Ozen T, Kavak V, Kirici Y, Oztas E, Soysal HA, Unur E, Ekinci N, Karaca O, Malakhova O, Kocaoglu M, Toker S, Taser F, Kilincoglu V, Yurtgun MF, Dalcik C, Zeybek A, Baroncini M, Peltier J, Jissendi P, Pruvo JP, Francke JP, Prevot V, Kosif R, Arifoglu Y, Diramali M, Sarsilmaz M, Kose E, Ogeturk M, Akpinar B, Kus I, Meydan S, Kara A, Kurtoglu Z, Tekdemir I, Elhan A, Bas O, Odaci E, Mollaoglu H, Ucok K, Kaplan S, Senoglu M, Nacitarhan V, Kurutas EB, Senoglu N, Altun I, Atli Y, Ozbag D, Karakas S, Bilgin MD, Tellioglu AM, Ozlem S, Akcanal B, Yildiz Y, Gunes H, Kose H, Uzum I, Gundogmus UN, Caglayan C, Pavlova V, Dimitrova M, Georgieva L, Nikolova E, Uzmansel D, Ozturk NC, Saylam CY, Ozgiray E, Orhan M, Cagli S, Zileli M, Ozkan D, Akkaya T, Comert A, Balikci N, Ozdemir E, Gumus H, Ergul Z, Kaya O, Altun S, Unlu RE, Orbay H, Kim DI, Han SH, Kim YS, Kim HJ, Lee KS, Elcioglu O, Ozden H, Guven G, Imre N, Yalcin B, Ozan H, Akyer P, Guvencer M, Karatosun V, Sagoo MG, Aland RC, Ustuner D, Ustuner MC, Ai J, Ghazi SR, Mansouri SH, Tuncer MC, Aluclu MU, Karabulut O, Hatipoglu ES, Nazaroglu H, Icke C, Akbay E, Gunay T, Icke S, Yildiz S, Yazar F, Barlas BO, Zahoi DE, Kavakli A, Tas U, Dabak DO, Sapmaz HI, Kocabiyik N, Ozer CM, Ozcan A, Elevli L, Desdicioglu K, Alanbay I, Govsa F, Akdogan I, Kiroglu Y, Onur S, Evcil EH, Cankara N, Malas MA, Kalcioglu MT, Duman S, Ulcay T, Uzun A, Karabulut Z, Barut C, Sevinc O, Yurdakan G, Kacar D, Erdogan AR, Kurt H, Demir B, Saltan M, Burukoglu D, Degirmenci I, Erdogan A, Damar O, Is M, Bayramoglu G, Kabay S, Uysal O, Senturk H, Bayramoglu A, Ozbayar C, Kutlu A, Canbek M, Cevli SC, Hancerlioglu O, Koplay M, Aksakalli E, Dikici F, Kale A, Gayretli O, Gurses IA, Ozdemir ST, Ercan I, Baskan EB, Yilmaz M, Ozkaya G, Saricaoglu H, Erturk M, Kayalioglu G, Uzel M, Kahraman G, Tanyeli E, Soyluoglu AI, Tacar O, Demirant A, Bilgin M, Karadede A, Aktas A, Koyuncu E, Sulak O, Albay S, Ozguner G, Ozbek E, Ozturk AH, Demirci T, Ciftcioglu E, Demir MT, Kopuz C, Eroglu E, Gedikli S, Ozyurek H, Nural MS, Incesu L, Ogur G, Kara E, Celebi B, Yildiz A, Altunkaynak BZ, Kuvat SV, Tagil SM, Ertekin C, Uysal H, Bademkiran F, Albayrak N, Esmer AF, Coskun NK, Sindel M, Kizilay F, Yalin S, Karapinar N, Tokdemir M, Karakurt L, Tumkaya L, Korkmaz A, Ayas B, Ciftci N, Terzi Y, Baran O, Nergiz Y, Akkus M, Aluclu U, Topal AE, Yuksel D, Acar HI, Kendir S, Hekimoglu E, Basman D, Ozener B, Pelin C, Zagyapan R, Kurkcuoglu A, Koc M, Erdinc M, Erdinc L, Kelle I, Sancakdar E, Cetin N, Tunik S, Yildirim A, Kaplanoglu I, Ayaz E, Ilhan N, Okumus M, Yuksel KZ, Ciralik H, Yilmaz Z, Gumusalan Y, Gamsizkan M, Kazkayasi M, Unver Dogan N, Uysal II, Karalezli A, Fazliogullari Z, Buyukmumcu M, Bozkurt MC, Cicekcibasi AE, Demiryurek D, Ozsoy MH, Tuccar E, Baran OP, Soker S, Bahceci S, Nasir Y, Yilmaz MT, Cicekcibasi EA, Ulusoy M, Gunaslan P, Bilge N, Akkaya M, Genc A, Akcer S, Gonul Y, Cosar E, Koken G, Ari I, Bakirci S, Kafa IM, Uysal M, Karabulut AK, Keles B, Emlik D, Uyar Y, Ozturk K, Yilmaz NA, Salbacak A, Kacira BK, Arazi M, Demirci S, Kiresi D, Gumus S, Seker M, Uyar M, Astaneh ME, Khorshid A, Uygur R, Songur A, Sonmez OF, Dogan KH, Kolcu G, Iliescu M, Bordei P, Iliescu D, Ciobotaru C, Lucescu V, Covaleov A, Ionescu C, Guirao M, Páramo E, Mutuberria R, Sánchez-Montesinos I, Roda O, Girón F, Lopez-Soler M, Campos-López R, Guirao-Piñeiro M, Pascual-Morenilla MT, Sanchez-Montesinos I, Pascual MT, Garzon I, Serrato D, Nieto-Aguilar R, Sanchez-Quevedo M, Ozdemir MB, Ozean RH, Bagdatli D, Adiguzel E, Dogan Z, Aycan O, Vardi N, Erkal HS, Ozturk H, Mocanu S, Stefanescu C, Ionescu A, Talpes R, Sapte E, Dina C, Surdu L, Bulbuc I, Medina MT, Medina J, López-Soler M, Martin-Oviedo C, Lowy-Benoliel A, Maranillo E, Martinez-Guirado T, Sañudo J, Scola B, Vazquez T, Arráez-Aybar LA, Conejo-Menor JL, Gonzáles-Gómez CC, Torres-García AJ, Nasu H, Chiba S, Gutierrez-Semillera M, Paksoy Y, Kalaycioglu A, Yildirim M, Ozyasar A, Ozdogmus O, Cakmak YO, Verimli U, Cavdar S, Yildizhan B, Aktan Ikiz ZA, Ucerler H, Ozgur Z, Yilmaz S, Demirtas A, Mavili E, Hacialiogullari M, Susar H, Arslan S, Aycan K, Ozkaya V, Pilmane M, Boka S, Ortug G, Ramirez C, Pascual-Font A, Valderrama-Canales F, Kucukalic A, Kapur E, Talovic E, Baca V, Grill R, Horak Z, Kachlik D, Dzupa V, Konarik M, Knize J, Veleminsky P, Smrzova T, Otcenasek M, Chmelova J, Kheck M, Cupka T, Hnatek L, van der Meijs F, Cech P, Musil V, Ozkan HM, Muratli SK, Tayefi H, Ergur I, Kiray A, Toktas M, Alkoc O, Acar T, Uzun I, Ozen OA, Aycicek A, Alkoc OA, Unlu M, Corumlu U, Ikiz IC, Oygucu IH, Sendemir E, Kaner T, Caglar V, Eser O, Iyigun O, Pirzirenli G, Kaya AH, Aydin ME, Celik F, True H, Ozkaya S, Ergur BU, Zeybek G, Bacakoglu K, Tadjalli M, Poostpasand A, Mansouiri SH, Allahvaisi O, Soleimanirad J, Nikkhoo B, Nagato Y, Haruki Y, Yazawa K, Okazaki T, Haida M, Imai Y, Peirouvi T, Mahzad-Sadaghiani M, Noroozinia F, Siamak S, Farjah G, Mola S, Biegaj E, Skadorwa T, Pawlewicz K, Kapolka R, Chachulska A, Zabicka J, Krasowska A, Prusik A, Jaczewski G, Kolesnik A, Taghavi MM, Alavi SH, Moallem SA, Safikhani Z, Panahi M, Dabiri S, Shekaari MA, Latorre R, Soria F, Lopez-Albors O, Sarria R, Ayala I, Serrano I, Perez-Cuadrado E, Musienko V, Tkachenko D, Colakoglu N, Kus MA, Jalali M, Nikravesh MR, Moeen AA, Karimfar MH, Rafighdoost H, Mohammadi S, Korneeva M, Rafighdoust H, Lovasova K, Bolekova A, Kluchova D, Sulla I, Kapitonova MY, Syed Ahmad Fuad SB, Jayakaran F, Shams AR, Aghaee F, Baqer Z, Faroki M, Das S, Kassim N, Latiff A, Suhaimi F, Ghafar N, Hlaing KP, Maatoq I, Othman F, Kiray M, Bagriyanik HA, Pekcetin C, Ozogul C, Fidan M, Sun F, Sanchez-Margallo F, Gil F, Crisostomo V, Uson J, Ramirez G, Turamanlar O, Kirpiko O, Haktanir A, Climent S, Losilla S, Climent M, Sarikcioglu L, Senol Y, Yildirim FB, Utuk A, Kunicki J, Pasbakhsh P, Omidi N, Omidi H, Nazhvani FD, Ghalebi SR, Javan N, Mohagery A, Bideskan AR, Taheri MM, Fazel AR, Tiengo C, Macchi V, Stecco C, Porzionato A, Mazzoleni F, De Caro R, Clemente A, Morra A, Greco P, Pavan P, Natali A, Demir M, Dokur M, Acer N, Mavi A, Matveeva N, Lazarova D, Korneti K, Jovevska S, Jurkovik D, Papazova M, Havasi M, Alboghobeish N, Savari A, Salamat N, Sharifi M, Kwak HH, Hu KS, Kim GC, Park BS, Sinav A, Gulati AK, Gulati NK, Alshammary H, Nazhvani SD, Vafafar A, Esmaeilpour T, Bahmanpour S, Elyasi L, Monabbati A, Ghanadi M, Paryani MR, Gilanpour H, Amirsam B, Omaña RE, López SG, De la Garza Castro O, Vega EU, Lopez SG, Talebpour F, Golmohammadi R, Dashti G, Atlasi MA, Mehdizadeh M, Bahadori MH, Joghataei MT, Hatami L, Boroujeni MB, Estakhr J, Esfandiary E, Marzban M, Bakhtiary M, Modiry N, Jafarpur M, Mofidpur H, Mahmoudian A, Jafarpour M, Mahmoudian AR, Sanjarmousavi N, Doassans I, Sorrenti N, Decuadro G, Saibene A, Poumayrac M, Laza S, Almiron C, Vergara ME, Soria V, Lasa S, Perez A, Castro G, Maria AS, Soleimani M, Katebi M, Bakhshayesh M, Oner M, Halici M, Yikilmaz A, Guney A, Turk Y, Edizer M, Beden U, Icten N, Afshar M, Hasanzadeh Taheri MM, Moalem A, Golalipour MJ, Tamizi A, Ahi M, Mohammadpour S, Maiery A, Acikel C, Ulkur E, Karagoz H, Celikoz B, Bedi K, Ginus P, Golalipoor MJ, Mohammadi MR, Jhand P, Mansourian AR, Hosseinpoor K, Keshtkar AA, Alsaffar R, Balajadeh BK, Ghafari S, Azarhosh R, Fazeli SA, Jahanshahi M, Gharravi AM, Alicioglu B, Karakas HM, Harma A, Yang HM, Won SY, Lee JG, Lee JY, Kim YR, Song WC, Koh KS, Hwang EN, Choi HG, Kim SH, Kim SY, Hur MS, Ulucam E, Celbis O, Kim DH, Hong HS, Choi JH, Park JT, Kim HC, Abbasi H, Hosseinipanah SM, Hosseini M, Amani A, Ashrafi HR, Sadeghimehr M, Sheverdin V, Amani Z, Ashrafi A, Ashrafi AR, Javad H, Kachap MJ, Poumayrac MC, Almirón C, Rivara A, Sirilo A, Freire D, Cirillo A, Veragara ME, Krmek V, Krmek N, Jo-Osvatic A, Nikolic V, Radic R, Tubbs RS, Loukas M, Fogg Q, Ashwood N, Cilingiroglu S, Ozbakir C, Mazoochi T, Sabanciogullari V, Gumus C, Erdil FH, Cimen M, Moodi H, Ghiasi F, Akbari A, Hami J, Khazei M, Haghparast E, Mitsakis I, Anastasiou A, Mitsakis M, Sianou K, Hainoglou R, Francisco M, Mitsaki C, Konstantinidi M, Prapa S, Leksan I, Mrcela T, Selthofer R, Kermanian F, Ahmadpoor ME, Dalili N, Elian AH, Moaiery A, Jamalpour Z, Nourani MR, Asgari A, Hassanzadeh Taheri MM, Ebrahimzadeh A, Eftekharvaghefi SH, Mohammadi A, Sheibani V, Nematollahi-Mahani SN, Latifpour M, Deilami M, Soroure-Azimzadeh B, Nabipour F, Najafipour H, Nakhaee N, Yaghoobi M, Eftekharvaghefi R, Salehinejad P, Azizi H, Riasi HR, Nobakht M, Asalgoo S, Rahbar R, Najafzadeh N, Moosavizadeh K, Ezzatabadypour M, Majidi M, Malekpor-Afshar R, Karimzade F, Hoseini M, Bayat M, Gorgi A, Nezhadi A, Bakhtiari M, Jazi HR, Jafaryan M, Haghir H, Rahimi S, Rassouli FB, Gorji A, Habibi A, Pouya F, Mousavi A, Rajabalian S, Abolidokht A, Khanlarkhani N, Naderian H, Berjis N, Namavar MR, Talaei T, Mazaheri Z, Monabati A, Kosar MI, Karacan K, Chegini H, Nikzad H, Ayhan E, Ustundag S, Akkin SM, Ogut T, Rayegan P, Meibodi MA, Ghaem RM, Zargarpoor R, Eftekhar Vaghefi SH, Moshkdanian G, Poya F, Kohestani H, Abarghoeai RR, Abarghoeai PR, Mahmodi AA, Poraboli A, Kohestani HR, Vaghefi RE, Eftekhar Vaghefy SH, Vaghefy RE, Saba M, Javadnia F, Zhaleh M, Nezhad DB, Gholami MR, Piagkou M, Aikaterini VK, Piagkos G, Douvetzemis S, Skandalakis P, Anagnostopoulou S, Papadopoulos N, Celik HH, Tatar I, Tatar EC, Mocan BO, Sargon MF, Denk CC, Rasoolijazi H, Joghataie MT, Roghani M, Dinc G, Kurklu M, Ozboluk S, Komurcu M, Koebke J, Balioglu MB, Kaygusuz MA, Bozkus FS, Korkmaz O, Bayram SB, Can MA, Nasiri E, Jafar-Kazemi K, Maghoul S, Amini A, Hassanzade MM, Davari MH, Van Hoof T, Gomes GT, Audenaert E, Verstraete K, Kerckaert I, D'Herde K, Benninger B, Hedley G, Filipoiu FM, Tarta E, Enyedi M, Pantu C, Stanciulescu R, Skobowiat C, Calka J, Majewski M, Rezaian M, Yaghoobfar A, Hamedi S, and Shomali T
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- 2009
16. Cancer antigen 125 levels and increased risk of new-onset atrial fibrillation
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Yucel, H., primary, Kaya, H., additional, Zorlu, A., additional, Yıldırımlı, K., additional, Sancakdar, E., additional, Gunes, H., additional, Kurt, R., additional, Ozgul, U., additional, Turgut, O.O., additional, and Yilmaz, M.B., additional
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- 2014
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17. Serum adiponectin, leptin, and interleukin 6 levels as adipocytokines in children with febrile seizures.
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Güven, A. S., Icagasioglu, F. D., Duksal, F., Sancakdar, E., Alaygut, D., Uysal, E. B., Akkar, İ, Oflaz, M. B., and Kaya, A.
- Subjects
ADIPOKINES ,ADIPOSE tissues ,SEROCONVERSION ,BLOOD plasma ,FEBRILE seizures - Abstract
Proinflammatory and anti-inflammatory cytokines have an important role in the pathogenesis of febrile seizures (FS). Adipocytokines like interleukin 6 (IL-6), leptin, and adiponectin released from adipose tissue play a role in inflammation. This study aimed to assess the probable role of adipose tissue in children with FS. We measured serum IL-6, leptin, and adiponectin levels and evaluated clinical and laboratory findings in children with FS (n = 32) and compared the results with the values of children of the same age with febrile illness without seizures (febrile control, FC; n = 26) and healthy control group (HC; n = 29). The serum levels of white blood cells, C-reactive protein, IL-6, leptin, and adiponectin were found to be significantly higher, while serum hemoglobin (Hb) levels were found to be significantly lower in FS and FC groups than in the HC group (p < 0.001). When we compared the FS with the FC group, the serum Hb levels were significantly lower in the FS group than those in the FC group (p = 0.001). There was no significant difference between the FS and FC group with regard to the serum levels of these adipocytokines (p > 0.05). Our data showed that elevated levels of these adipocytokines as acute phase reactants in FS and FC groups did not contribute to the development of FS. [ABSTRACT FROM AUTHOR]
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- 2015
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18. Serum 17-OH progesterone and free testosterone levels in women patients with Familial Mediterranean Fever: a pivotal study.
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DEVECI, K., GOKAKIN, A. K., BOZTOSUN, A., DEVECI, H., SENEL, S., USLU, A. U., and SANCAKDAR, E.
- Abstract
BACKGROUND: Familial Mediterranean Fever (FMF) is an autosomal recessive disease characterized by short lived, febrile serosae inflammatory attacks. FMF has various effects in multiple systems and organs. AIM: In the present study, our aim was to evaluate adrenal steroidogenesis in female FMF patients. PATIENTS AND METHODS: There were 71 women in the study including 41 women with FMF and 30 women as healthy control group (HC group). Of 41 FMF patients, twenty were evaluated in attack period (AP-FMF group) whereas 21 of them were evaluated in attack-free period (AFP-FMF group). In all subjects; serum free testosterone, 17-OHP levels as hormones, IL-1 beta, TNF-alpha, IL-6, IL-18 as proinflammatory cytokines, CRP, fibrinogen, white blood cell (WBC) counts, and erythrocyte sedimentation rate (ESR) as acute phase reactants were measured in samples of venous blood taken in the morning before breakfast. RESULTS: Serum 17-OHP levels in AP-FMF group and AFP-FMF group were higher than in HC group (p < 0.001). A positive correlation was detected between serum levels of 17-OHP and IL-1 beta in FMF patients (p = 0.006; r = 0.486). There was no difference between FMF patients and HC group in terms of free testosterone levels (p > 0.05). CONCLUSIONS: Our results showed an increase in 17-OHP levels in FMF patients. These results may indicate that, regardless to the attack period adrenal steroidogenesis could be affected negatively in FMF patients. [ABSTRACT FROM AUTHOR]
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- 2013
19. Cystatin C in serum as an early marker of renal involvement in Familial Mediterranean Fever patients.
- Author
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DEVECI, K., GOKAKIN, A. K., SENEL, S., DEVECI, H., USLU, A. U., and SANCAKDAR, E.
- Abstract
BACKGROUND: The major renal involvement in Familial Mediterranean Fever (FMF) is the occurrence of amyloidosis that primarily affects the kidneys manifested by proteinuria and ending in death from renal failure. AIM: This study aims to investigate whether serum cystatin (cys-C) levels could be used as an early marker of renal involvement in FMF patients. PATIENTS AND METHODS: Forty-six patients with FMF during the attack period (AP), and 41 patients with FMF during attack-free periods (AFP), and 11 patients with FMF associated amyloidosis, and 38 healthy controls were enrolled in the study. We determined cys-C levels in the serum of FMF patients and healthy controls. RESULTS: Serum cys-C levels were significantly increased in patients with FMF and secondary amyloidosis, and serum cys-C is a more accurate and efficient marker for detecting renal involvement than estimated glomerular filtration rate (e-GFR) in patients with FMF. CONCLUSIONS: We propose a cutoff level of the serum cys-C of 876.5 pg/mL for screening renal involvement in patients with FMF, and amyloidosis should be strongly suspected when the serum cys-C reaches 1565.5 pg/mL. [ABSTRACT FROM AUTHOR]
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- 2013
20. Poster session Thursday 12 December - AM: 12/12/2013, 08:30-12:30 * Location: Poster area
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Abdovic, E, Abdovic, S, Hristova, K, Hristova, K, Katova, TZ, Katova, TZ, Gocheva, N, Gocheva, N, Pavlova, M, Pavlova, M, Gurzun, M M, Ionescu, A, Canpolat, U, Yorgun, H, Sunman, H, Sahiner, L, Kaya, EB, Ozer, N, Tokgozoglu, L, Kabakci, G, Aytemir, K, Oto, A, Gonella, A, Dascenzo, F, Casasso, F, Conte, E, Margaria, F, Grosso Marra, W, Frea, S, Morello, M, Bobbio, M, Gaita, F, Seo, HY, Lee, SP, Lee, JM, Yoon, YE, Park, E, Kim, HK, Park, SJ, Lee, H, Kim, YJ, Sohn, DW, Nemes, A, Domsik, P, Kalapos, A, Orosz, A, Lengyel, C, Forster, T, Enache, R, Muraru, D, Popescu, BA, Calin, A, Nastase, O, Botezatu, D, Purcarea, F, Rosca, M, Beladan, CC, Ginghina, C, Canpolat, U, Aytemir, K, Ozer, N, Yorgun, H, Sahiner, L, Kaya, EB, Oto, A, Trial, Turkish Atrial Fibrosis, Muraru, D, Piasentini, E, Mihaila, S, Padayattil Jose, S, Peluso, D, Ucci, L, Naso, P, Puma, L, Iliceto, S, Badano, LP, Cikes, M, Jakus, N, Sutherland, GR, Haemers, P, Dhooge, J, Claus, P, Yurdakul, S, Oner, FATMA, Direskeneli, HANER, Sahin, TAYLAN, Cengiz, BETUL, Ercan, G, Bozkurt, AYSEN, Aytekin, SAIDE, Osa Saez, A M, Rodriguez-Serrano, M, Lopez-Vilella, R, Buendia-Fuentes, F, Domingo-Valero, D, Quesada-Carmona, A, Miro-Palau, VE, Arnau-Vives, MA, Palencia-Perez, M, Rueda-Soriano, J, Lipczynska, M, Piotr Szymanski, PS, Anna Klisiewicz, AK, Lukasz Mazurkiewicz, LM, Piotr Hoffman, PH, Kim, KH, Cho, SK, Ahn, Y, Jeong, MH, Cho, JG, Park, JC, Chinali, M, Franceschini, A, Matteucci, MC, Doyon, A, Esposito, C, Del Pasqua, A, Rinelli, G, Schaefer, F, group, the 4C study, Kowalik, E, Klisiewicz, A, Rybicka, J, Szymanski, P, Biernacka, EK, Hoffman, P, Lee, S, Kim, W, Yun, H, Jung, L, Kim, E, Ko, J, Ruddox, V, Norum, IB, Edvardsen, T, Baekkevar, M, Otterstad, JE, Erdei, T, Edwards, J, Braim, D, Yousef, Z, Fraser, AG, Cardiff, Investigators, MEDIA, Melcher, A, Reiner, B, Hansen, A, Strandberg, LE, Caidahl, K, Wellnhofer, E, Kriatselis, C, Gerd-Li, H, Furundzija, V, Thnabalasingam, U, Fleck, E, Graefe, M, Park, YJ, Moon, JG, Ahn, TH, Baydar, O, Kadriye Kilickesmez, KK, Ugur Coskun, UC, Polat Canbolat, PC, Veysel Oktay, VO, Umit Yasar Sinan, US, Okay Abaci, OA, Cuneyt Kocas, CK, Sinan Uner, SU, Serdar Kucukoglu, SK, Ferferieva, V, Claus, P, Rademakers, F, Dhooge, J, Le, T T, Wong, P, Tee, N, Huang, F, Tan, RS, Altman, M, Logeart, D, Bergerot, C, Gellen, B, Pare, C, Gerard, S, Sirol, M, Vicaut, E, Mercadier, JJ, Derumeaux, G A, investigators, PREGICA, Park, T-H, Park, J-I, Shin, S-W, Yun, S-H, Lee, J-E, Makavos, G, Kouris, N, Keramida, K, Dagre, A, Ntarladimas, I, Kostopoulos, V, Damaskos, D, Olympios, CD, Leong, DP, Piers, SRD, Hoogslag, GE, Hoke, U, Thijssen, J, Ajmone Marsan, N, Schalij, MJ, Bax, JJ, Zeppenfeld, K, Delgado, V, Rio, P, Branco, L, Galrinho, A, Cacela, D, Abreu, J, Timoteo, A, Teixeira, P, Pereira-Da-Silva, T, Selas, M, Cruz Ferreira, R, Popa, B A, Zamfir, L, Novelli, E, Lanzillo, G, Karazanishvili, L, Musica, G, Stelian, E, Benea, D, Diena, M, Cerin, G, Fusini, L, Mirea, O, Tamborini, G, Muratori, M, Gripari, P, Ghulam Ali, S, Cefalu, C, Maffessanti, F, Andreini, D, Pepi, M, Mamdoo, F, Goncalves, A, Peters, F, Matioda, H, Govender, S, Dos Santos, C, Essop, MR, Kuznetsov, V A, Yaroslavskaya, E I, Pushkarev, G S, Krinochkin, D V, Kolunin, G V, Bennadji, A, Hascoet, S, Dulac, Y, Hadeed, K, Peyre, M, Ricco, L, Clement, L, Acar, P, Ding, WH, Zhao, Y, Lindqvist, P, Nilson, J, Winter, R, Holmgren, A, Ruck, A, Henein, MY, Illatopa, V, Cordova, F, Espinoza, D, Ortega, J, Cavalcante, JL, Patel, MT, Katz, W, Schindler, J, Crock, F, Khanna, MK, Khandhar, S, Tsuruta, H, Kohsaka, S, Murata, M, Yasuda, R, Tokuda, H, Kawamura, A, Maekawa, Y, Hayashida, K, Fukuda, K, Le Tourneau, T, Kyndt, F, Lecointe, S, Duval, D, Rimbert, A, Merot, J, Trochu, JN, Probst, V, Le Marec, H, Schott, JJ, Veronesi, F, Addetia, K, Corsi, C, Lamberti, C, Lang, RM, Mor-Avi, V, Gjerdalen, G F, Hisdal, J, Solberg, EE, Andersen, TE, Radunovic, Z, Steine, K, Maffessanti, F, Gripari, P, Tamborini, G, Muratori, M, Fusini, L, Ferrari, C, Caiani, EG, Alamanni, F, Bartorelli, AL, Pepi, M, Dascenzi, F, Cameli, M, Iadanza, A, Lisi, M, Reccia, R, Curci, V, Sinicropi, G, Henein, M, Pierli, C, Mondillo, S, Rekhraj, S, Hoole, SP, Mcnab, DC, Densem, CG, Boyd, J, Parker, K, Shapiro, LM, Rana, BS, Kotrc, M, Vandendriessche, T, Bartunek, J, Claeys, MJ, Vanderheyden, M, Paelinck, B, De Bock, D, De Maeyer, C, Vrints, C, Penicka, M, Silveira, C, Albuquerque, ESA, Lamprea, DL, Larangeiras, VL, Moreira, CRPM, Victor Filho, MVF, Alencar, BMA, Silveira, AQMS, Castillo, JMDC, Zambon, E, Iorio, A, Carriere, C, Pantano, A, Barbati, G, Bobbo, M, Abate, E, Pinamonti, B, Di Lenarda, A, Sinagra, G, Salemi, V M C, Tavares, L, Ferreira Filho, JCA, Oliveira, AM, Pessoa, FG, Ramires, F, Fernandes, F, Mady, C, Cavarretta, E, Lotrionte, M, Abbate, A, Mezzaroma, E, De Marco, E, Peruzzi, M, Loperfido, F, Biondi-Zoccai, G, Frati, G, Palazzoni, G, Park, T-H, Lee, J-E, Lee, D-H, Park, J-S, Park, K, Kim, M-H, Kim, Y-D, Van T Sant, J, Gathier, WA, Leenders, GE, Meine, M, Doevendans, PA, Cramer, MJ, Poyhonen, P, Kivisto, S, Holmstrom, M, Hanninen, H, Schnell, F, Betancur, J, Daudin, M, Simon, A, Carre, F, Tavard, F, Hernandez, A, Garreau, M, Donal, E, Calore, C, Muraru, D, Badano, LP, Melacini, P, Mihaila, S, Denas, G, Naso, P, Casablanca, S, Santi, F, Iliceto, S, Aggeli, C, Venieri, E, Felekos, I, Anastasakis, A, Ritsatos, K, Kakiouzi, V, Kastellanos, S, Cutajar, I, Stefanadis, C, Palecek, T, Honzikova, J, Poupetova, H, Vlaskova, H, Kuchynka, P, Linhart, A, Elmasry, O, Mohamed, MH, Elguindy, WM, Bishara, PNI, Garcia-Gonzalez, P, Cozar-Santiago, P, Bochard-Villanueva, B, Fabregat-Andres, O, Cubillos-Arango, A, Valle-Munoz, A, Ferrer-Rebolleda, J, Paya-Serrano, R, Estornell-Erill, J, Ridocci-Soriano, F, Jensen, M, Havndrup, O, Christiansen, M, Andersen, PS, Axelsson, A, Kober, L, Bundgaard, H, Karapinar, H, Kaya, A, Uysal, EB, Guven, AS, Kucukdurmaz, Z, Oflaz, MB, Deveci, K, Sancakdar, E, Gul, I, Yilmaz, A, Tigen, M K, Karaahmet, T, Dundar, C, Yalcinsoy, M, Tasar, O, Bulut, M, Takir, M, Akkaya, E, Jedrzejewska, I, Braksator, W, Krol, W, Swiatowiec, A, Dluzniewski, M, Lipari, P, Bonapace, S, Zenari, L, Valbusa, F, Rossi, A, Lanzoni, L, Molon, G, Canali, G, Campopiano, E, Barbieri, E, Rueda Calle, E, Alfaro Rubio, F, Gomez Gonzalez, J, Gonzalez Santos, P, Cameli, M, Lisi, M, Focardi, M, Dascenzi, F, Solari, M, Galderisi, M, Mondillo, S, Pratali, L, Bruno, R M, Corciu, AI, Comassi, M, Passera, M, Gastaldelli, A, Mrakic-Sposta, S, Vezzoli, A, Picano, E, Perry, R, Penhall, A, De Pasquale, C, Selvanayagam, J, Joseph, M, Simova, I I, Katova, T M, Kostova, V, Hristova, K, Lalov, I, Dascenzi, F, Pelliccia, A, Natali, BM, Cameli, M, Alvino, F, Zorzi, A, Corrado, D, Bonifazi, M, Mondillo, S, Rees, E, Rakebrandt, F, Rees, DA, Halcox, JP, Fraser, AG, Odriscoll, J, Lau, N, Perez-Lopez, M, Sharma, R, Lichodziejewska, B, Goliszek, S, Kurnicka, K, Kostrubiec, M, Dzikowska Diduch, O, Krupa, M, Grudzka, K, Ciurzynski, M, Palczewski, P, Pruszczyk, P, Gheorghe, LL, Castillo Ortiz, J, Del Pozo Contreras, R, Calle Perez, G, Sancho Jaldon, M, Cabeza Lainez, P, Vazquez Garcia, R, Fernandez Garcia, P, Chueca Gonzalez, E, Arana Granados, R, Zhao, XX, Xu, XD, Bai, Y, Qin, YW, Leren, IS, Hasselberg, NE, Saberniak, J, Leren, TP, Edvardsen, T, Haugaa, KH, Daraban, A M, Sutherland, GR, Claus, P, Werner, B, Gewillig, M, Voigt, JU, Santoro, A, Ierano, P, De Stefano, F, Esposito, R, De Palma, D, Ippolito, R, Tufano, A, Galderisi, M, Costa, R, Fischer, C, Rodrigues, A, Monaco, C, Lira Filho, E, Vieira, M, Cordovil, A, Oliveira, E, Mohry, S, Gaudron, P, Niemann, M, Herrmann, S, Strotmann, J, Beer, M, Hu, K, Bijnens, B, Ertl, G, Weidemann, F, Baktir, AO, Sarli, B, Cicek, M, Karakas, MS, Saglam, H, Arinc, H, Akil, MA, Kaya, H, Ertas, F, Bilik, MZ, Yildiz, A, Oylumlu, M, Acet, H, Aydin, M, Yuksel, M, Alan, S, Odriscoll, J, Gravina, A, Di Fino, S, Thompson, M, Karthigelasingham, A, Ray, K, Sharma, R, De Chiara, B, Russo, CF, Alloni, M, Belli, O, Spano, F, Botta, L, Palmieri, B, Martinelli, L, Giannattasio, C, Moreo, A, Mateescu, AD, La Carrubba, S, Vriz, O, Di Bello, V, Carerj, S, Zito, C, Ginghina, C, Popescu, BA, Nicolosi, GL, Antonini-Canterin, F, Malev, E, Omelchenko, M, Vasina, L, Luneva, E, Zemtsovsky, E, Cikes, M, Velagic, V, Gasparovic, H, Kopjar, T, Colak, Z, Hlupic, LJ, Biocina, B, Milicic, D, Tomaszewski, A, Kutarski, A, Poterala, M, Tomaszewski, M, Brzozowski, W, Kijima, Y, Akagi, T, Nakagawa, K, Ikeda, M, Watanabe, N, Ueoka, A, Takaya, Y, Oe, H, Toh, N, Ito, H, Bochard Villanueva, B, Paya-Serrano, R, Fabregat-Andres, O, Garcia-Gonzalez, P, Perez-Bosca, JL, Cubillos-Arango, A, Chacon-Hernandez, N, Higueras-Ortega, L, De La Espriella-Juan, R, Ridocci-Soriano, F, Noack, T, Mukherjee, C, Ionasec, RI, Voigt, I, Kiefer, P, Hoebartner, M, Misfeld, M, Mohr, F-W, Seeburger, J, Daraban, A M, Baltussen, L, Amzulescu, MS, Bogaert, J, Jassens, S, Voigt, JU, Duchateau, N, Giraldeau, G, Gabrielli, L, Penela, D, Evertz, R, Mont, L, Brugada, J, Berruezo, A, Bijnens, BH, Sitges, M, Yoshikawa, H, Suzuki, M, Hashimoto, G, Kusunose, Y, Otsuka, T, Nakamura, M, Sugi, K, Ruiz Ortiz, M, Mesa, D, Romo, E, Delgado, M, Seoane, T, Martin, M, Carrasco, F, Lopez Granados, A, Arizon, JM, Suarez De Lezo, J, Magalhaes, A, Cortez-Dias, N, Silva, D, Menezes, M, Saraiva, M, Santos, L, Costa, A, Costa, L, Nunes Diogo, A, Fiuza, M, Ren, B, De Groot-De Laat, LE, Mcghie, J, Vletter, WB, Geleijnse, ML, Toda, H, Oe, H, Osawa, K, Miyoshi, T, Ugawa, S, Toh, N, Nakamura, K, Kohno, K, Morita, H, Ito, H, El Ghannudi, S, Germain, P, Samet, H, Jeung, M, Roy, C, Gangi, A, Orii, M, Hirata, K, Yamano, T, Tanimoto, T, Ino, Y, Yamaguchi, T, Kubo, T, Imanishi, T, Akasaka, T, Sunbul, M, Kivrak, T, Oguz, M, Ozguven, S, Gungor, S, Dede, F, Turoglu, HT, Yildizeli, B, Mutlu, B, Mihaila, S, Muraru, D, Piasentini, E, Peluso, D, Cucchini, U, Casablanca, S, Naso, P, Iliceto, S, Vinereanu, D, Badano, LP, Rodriguez Munoz, DA, Moya Mur, JL, Becker Filho, D, Gonzalez, A, Casas Rojo, E, Garcia Martin, A, Recio Vazquez, M, Rincon, LM, Fernandez Golfin, C, Zamorano Gomez, JL, Ledakowicz-Polak, A, Polak, L, Zielinska, M, Kamiyama, T, Nakade, T, Nakamura, Y, Ando, T, Kirimura, M, Inoue, Y, Sasaki, O, Nishioka, T, Farouk, H, Sakr, B, Elchilali, K, Said, K, Sorour, K, Salah, H, Mahmoud, G, Casanova Rodriguez, C, Cano Carrizal, R, Iglesias Del Valle, D, Martin Penato Molina, A, Garcia Garcia, A, Prieto Moriche, E, Alvarez Rubio, J, De Juan Bagua, J, Tejero Romero, C, Plaza Perez, I, Korlou, P, Stefanidis, A, Mpikakis, N, Ikonomidis, I, Anastasiadis, S, Komninos, K, Nikoloudi, P, Margos, P, and Pentzeridis, P
- Abstract
Purpose: Atrial fibrillation (AF) is the most prevalent sustained arrhythmia. It is a disease of the elderly and it is common in patients (pts) with structural heart disease. Hypertension (HA), hypertensive heart disease (HHD), diabetes mellitus (DM), coronary artery disease (CAD), heart failure (HF), and valvular heart disease (VHD) are recognized predisposing factors to AF. Objectives: To echocardiographicly disclose the most common predisposing morbidities to AF in our population sample. Methods: From June 2000 to February 2013, 3755 consecutive pts with AF were studied during echocardiographic check-up. According to transthoracic echo, pts were divided in groups based on dominative underlying heart diseases. Electrocardiographically documented AF was subdivided in two groups: transitory and chronic. Transitory AF fulfilled criteria for paroxysmal or persistent AF. Chronic AF were cases of long-standing persistent or permanent AF. Results: The median age was 72 years, age range between 16 and 96 years. There were 51.4% of females. Chronic AF was observed in 68.3% pts. Distribution of underlying heart diseases is shown in figure. Lone AF was diagnosed in only 25 pts, mostly in younger males (median age 48 years, range 29–59, men 80%). Chronic AF was predominant in groups with advanced cardiac remodeling such as dilatative cardiomyopaty (DCM) and VHD, mostly in elderly. HA and DM were found in 75.4% and 18.8%, respectively. Almost 1/2 of pts with AF had HF and 59.2% had diastolic HF. Conclusion: Up to now, echocardiographic categorization of the predisposing factors to AF was not reported. Echocardiographic evaluation of patients with AF could facilitate in identification and well-timed treatment of predisposing comorbidites.
Figure Etiological distribution of AF - Published
- 2013
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21. Cancer antigen 125 levels and increased risk of new-onset atrial fibrillation
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Hasan Yucel, Ali Zorlu, Okan Onur Turgut, U. Ozgul, Mehmet Yilmaz, Hakkı Kaya, Kutay Yildirimli, Recep Kurt, E. Sancakdar, Handan Gunes, [Yucel, H. -- Kaya, H. -- Zorlu, A. -- Yildirimli, K. -- Gunes, H. -- Kurt, R. -- Ozgul, U. -- Turgut, O. O. -- Yilmaz, M. B.] Cumhuriyet Univ, Dept Cardiol, Sch Med, Sivas, Turkey -- [Sancakdar, E.] Cumhuriyet Univ, Dept Biochem, Sch Med, Sivas, Turkey, Turgut, Okan -- 0000-0002-6847-3029, and YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628
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Male ,medicine.medical_specialty ,Turkey ,Cancer antigen 125 ,Heart failure ,Comorbidity ,Risk Assessment ,Sensitivity and Specificity ,Coronary artery disease ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Sinus rhythm ,Heart Failure ,Mitral regurgitation ,Univariate analysis ,Proportional hazards model ,business.industry ,Incidence ,Reproducibility of Results ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Prognosis ,Hospitalization ,CA-125 Antigen ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Prediction ,Biomarkers ,Systolic heart failure - Abstract
WOS: 000352651800003, PubMed ID: 25256054, Elevated cancer antigen 125 (CA-125) levels are associated with cardiopulmonary disorders such as acute and chronic heart failure (HF), coronary artery disease, chronic obstructive pulmonary disease, and atrial fibrillation (AF). The development of atrial fibrillation (AF) is related to morbidity and mortality in patients with HF: therefore, it is important to identify patients with increased risk for development of AF. We investigated whether plasma CA-125 levels in patients with hospitalized systolic HF could predict the development of AF. A total of 149 consecutive patients with sinus rhythm who were admitted to the emergency department with hospitalized systolic HF were evaluated prospectively. Serum CA-125 levels were obtained after initial stabilization during their hospital stay. AF developed in 36 (% 24.2) patients during a follow-up period of 22.1 +/- 11 months (range 3-61). CA-125 levels were significantly higher in patients who developed AF than in patients with sinus rhythm [99 U/ml (48-172) vs. 47 U/ml (18-108), p = 0.001]. The optimal cut-off level of CA-125 to predict development of AF was found to be > 68.49 U/ml. CA-125 > 68.49 U/ml, left atrial diameter, right ventricular dilatation, moderate to severe mitral and tricuspid regurgitations were found to have prognostic significance in univariate analysis. In a multivariate Cox proportional hazards model with the backward stepwise method, CA-125 > 68.49 U/ml (HR = 2.693, % 95 CI = 1.285-5.641, p = 0.009) and moderate to severe mitral regurgitation (HR = 2.708, % 95 CI = 1.295-5.663, p = 0.008) were associated with an increased risk of new-onset AF after adjustment for variables found to be statistically significant in univariate analysis and correlated with CA-125 level. CA-125 level is associated with the development of AF in patients with hospitalized systolic HF.
- Published
- 2015
22. Predictive role of neutrophil gelatinase-associated lipocalin in early diagnosis of platin-induced renal injury
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Ali Yilmaz, A Kerim Turesin, Köksal Deveci, Nalan Akgul Babacan, Turgut Kacan, Ayse Seker, Mehmet Metin Seker, Enver Sancakdar, and Seker, M.M., Medical Oncology Department, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Deveci, K., Biochemistry Department, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Seker, A., Public Health Directorate, Sivas, Turkey -- Sancakdar, E., Biochemistry Department, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Yilmaz, A., Internal Medicine Department, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Kerim Turesin, A., Internal Medicine Department, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Kacan, T., Medical Oncology Department, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Babacan, N.A., Medical Oncology Department, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey
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Male ,Cancer Research ,Organoplatinum Compounds ,Epidemiology ,Urine ,Docetaxel ,Gastroenterology ,Deoxycytidine ,Carboplatin ,chemistry.chemical_compound ,Neoplasms ,Antineoplastic Combined Chemotherapy Protocols ,Neoplasm Metastasis ,Nephrotoxicity ,Cancer ,Platin chemotherapy ,Neutrophil gelatinase-associated lipocalin ,Acute kidney injury ,Acute Kidney Injury ,Middle Aged ,Prognosis ,Lipocalins ,Oxaliplatin ,Oncology ,Creatinine ,Female ,Taxoids ,Fluorouracil ,medicine.drug ,Adult ,medicine.medical_specialty ,Paclitaxel ,Urinary system ,Lipocalin-2 ,Internal medicine ,Proto-Oncogene Proteins ,medicine ,Biomarkers, Tumor ,Humans ,Capecitabine ,Aged ,Neoplasm Staging ,Cisplatin ,business.industry ,Public Health, Environmental and Occupational Health ,medicine.disease ,Gemcitabine ,chemistry ,Immunology ,business ,Acute-Phase Proteins ,Follow-Up Studies - Abstract
Asian Pacific Organization for Cancer Prevention, Background: Acute kidney injury is an important issue in chemotherapy receiving patients an neutrophil gelatinase-associated lipocalin has been proposed as a novel marker. We here aimed to assess the role of urinary levels for assessment after platin exposure. Materials and Methods: Patients who had treated with cisplatin or carboplatin or oxaliplatin containg regimens were included in this study. Baseline and postchemotherapy serum urea, creatinine, urine neutrophil gelatinase-associated lipocalin and urine creatinine levels were determined. To avoid the effects of hydration during chemotherapy infusion the urinary neutrophil gelatinase-associated lipocalin/urine creatinine ratio was used to determine acute kidney injury. Results: Of a total of 42 patients receiving platin compounds,14 (33.3%) received cisplatin containing regimens, 14 (33.3%) received carboplatin and 14 (33.3%) oxaliplatin. The median age was 60 (37-76) years. Nineteen of the patients (45.2%) had lung cancer, 12 (28.6%) colorectal cancer and 11 (26.2%) others. The median pre and post chemotherapy urine neutrophil gelatinase-associated lipocalin/urine creatinin ratio was 15.6 ng/mg and 35.8 ng/mg (p=0.041) in the cisplatin group, 32.5 ng/mg and 86.3 ng/mg (p=0.004) in the carboplatin group and 40.9 ng/mg and 62.3 ng/ mg (p=0.243) in the oxaliplatin group. Conclusions: Nephrotoxicity is a serious side effect of chemotherapeutic agentslike cisplatin and carbopaltin, but only to a lower extent oxaliplatin. All platin compounds must be used carefully and urine neutrophil gelatinase-associated lipocalin measurement seems to be promising in detecting acute kidney injury earlier than with creatinine., Seker, M.M.; Medical Oncology Department, Faculty of Medicine, Cumhuriyet UniversityTurkey
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- 2015
23. Serum adiponectin, leptin, and interleukin 6 levels as adipocytokines in children with febrile seizures: The role of adipose tissue in febrile seizures
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Ali Kaya, Fatma Duksal, Elif Bilge Uysal, Fusun Dilara Icagasioglu, Ahmet Sami Güven, Enver Sancakdar, Akkar I, Mehmet Burhan Oflaz, Demet Alaygut, [Gueven, A. S. -- Icagasioglu, F. D.] Cumhuriyet Univ, Dept Pediat, Div Pediat Neurol, Fac Med, TR-58140 Sivas, Turkey -- [Duksal, F. -- Alaygut, D. -- Oflaz, M. B. -- Kaya, A.] Cumhuriyet Univ, Fac Med, Dept Pediat, TR-58140 Sivas, Turkey -- [Sancakdar, E.] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkey -- [Uysal, E. B.] Cumhuriyet Univ, Fac Med, Dept Microbiol, TR-58140 Sivas, Turkey -- [Akkar, I.] Sivas Govt Hosp, Dept Pediat, Sivas, Turkey, Oflaz, Mehmet Burhan -- 0000-0003-1515-4654, İÇAĞASIOĞLU, DİLARA FÜSUN, and KAYA, AYSEL
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Leptin ,Male ,medicine.medical_specialty ,Health, Toxicology and Mutagenesis ,Adipokine ,Adipose tissue ,Toxicology ,leptin ,Seizures, Febrile ,Proinflammatory cytokine ,Hemoglobins ,Leukocyte Count ,Adipokines ,Internal medicine ,febrile seizures ,Medicine ,Humans ,Adipocytokines ,Prospective Studies ,Interleukin 6 ,IL-6 ,adiponectin ,biology ,Adiponectin ,business.industry ,Interleukin-6 ,C-reactive protein ,Acute-phase protein ,Infant ,General Medicine ,Endocrinology ,C-Reactive Protein ,Adipose Tissue ,Child, Preschool ,Immunology ,biology.protein ,Female ,business - Abstract
WOS: 000360090300003, PubMed ID: 25504688, Proinflammatory and anti-inflammatory cytokines have an important role in the pathogenesis of febrile seizures (FS). Adipocytokines like interleukin 6 (IL-6), leptin, and adiponectin released from adipose tissue play a role in inflammation. This study aimed to assess the probable role of adipose tissue in children with FS. We measured serum IL-6, leptin, and adiponectin levels and evaluated clinical and laboratory findings in children with FS (n = 32) and compared the results with the values of children of the same age with febrile illness without seizures (febrile control, FC; n = 26) and healthy control group (HC; n = 29). The serum levels of white blood cells, C-reactive protein, IL-6, leptin, and adiponectin were found to be significantly higher, while serum hemoglobin (Hb) levels were found to be significantly lower in FS and FC groups than in the HC group (p < 0.001). When we compared the FS with the FC group, the serum Hb levels were significantly lower in the FS group than those in the FC group (p = 0.001). There was no significant difference between the FS and FC group with regard to the serum levels of these adipocytokines (p > 0.05). Our data showed that elevated levels of these adipocytokines as acute phase reactants in FS and FC groups did not contribute to the development of FS.
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- 2014
24. SDF-1/CXCL12 and CXCR4 gene variants, and elevated serum SDF-1 levels are associated with preeclampsia.
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Karakus S, Bagci B, Bagci G, Sancakdar E, Yildiz C, Akkar O, and Cetin A
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- Adult, Biomarkers blood, Case-Control Studies, Chemokine CXCL12 blood, Female, Humans, Polymorphism, Single Nucleotide, Pre-Eclampsia blood, Pregnancy, Young Adult, Chemokine CXCL12 genetics, Pre-Eclampsia genetics, Receptors, CXCR4 genetics
- Abstract
Objective: We aimed to compare the frequencies of stromal cell-derived factor-1 (SDF-1) 3'A and CXCR4 single-nucleotide polymorphisms (SNPs) and serum SDF-1 levels in patients with preeclampsia (PE)., Methods: In total, 89 women with PE and 89 control women were included in the study. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism method. Enzyme-linked immunosorbent assay method was used to measure serum SDF-1 level., Results: For SDF-1 3'A SNP, the frequency of GA genotype, total number of GA and AA genotypes, and the A allele frequency was higher in PE patients than controls (p = 0.04, 0.023, and 0.029, respectively). For CXCR4 SNP, the frequency of CT genotype, total number of CT and TT genotypes, and the T allele frequency were higher in PE patients than controls (p = 0.04, 0.006, and 0.005, respectively). SDF-1 serum level was detected higher in preeclamptic women compared with controls (p = 0.001). In PE patients, there was no significant association between serum SDF-1 levels and genotypes of SDF-1 3'A SNP. SDF-1 level was significantly higher in patients bearing CXCR4 CT genotype than CC genotype (p = 0.001). Furthermore, SDF-1 levels in patients bearing CT+TT genotype were found higher than that of patients with CC genotypes (p = 0.001)., Conclusion: Results of our study suggest that SDF-1 3'A and CXCR4 polymorphisms and elevated serum SDF-1 levels may have a role in the development of PE.
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- 2017
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25. Increased Levels of VEGF-A and HIF-1α in Turkish Children with Crimean-Congo Hemorrhagic Fever.
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Sefikogullari M, Kaya A, Aydin H, Sancakdar E, Celik VK, and Bagci G
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Background: Crimean-Congo Hemorrhagic Fever (CCHF) is a disease characterized by serious course, including acute viral fever, ecchymosis, thrombocytopenia, liver dysfunction and high rate of mortality. Hypoxia Inducible Factor-1α (HIF-1α) and Vascular Endothelial Growth Factor-A (VEGF-A) play an important role both in the inflammatory process and plasma leakage. The aim of this study was to define HIF-1α and VEGF-A serum levels obtained from CCHF patients and control group and to investigate whether these factors were correlated with the pathogenesis of this disease., Methods: Thirty cases younger than 17yr confirmed by RT-PCR and/or ELISA for CCHF were included in this study. Thirty age and sex matched healthy peoples were enrolled as controls. Blood samples collected from the patient and control groups. Serum levels of HIF-1α and VEGF-A were measured with ELISA., Results: Levels of HIF-1α and VEGF-A were statistically significantly increased in CCHF patients compared to the control group (P< 0.05). A significant positive correlation was found between the levels of HIF-1α and VEGF-A in the patient group (P< 0.01). The levels of ALT, AST, CK, aPTT, WBC and Thrombocyte count were significantly higher in the patients than in the control group (P< 0.001). A positive correlation was found among the levels of AST and CK from biochemical parameters and VEGF and HIF-1α in the patient group (P< 0.05)., Conclusion: HIF-1α and VEGF-A might play an important role in CCHF pathogenesis.
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- 2017
26. Elevated Serum CD95/FAS and HIF-1α Levels, but Not Tie-2 Levels, May Be Biomarkers in Patients With Severe Endometriosis: A Preliminary Report.
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Karakus S, Sancakdar E, Akkar O, Yildiz C, Demirpence O, and Cetin A
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- Adult, Biomarkers blood, Case-Control Studies, Endometriosis diagnosis, Endometriosis pathology, Female, Humans, Middle Aged, Neovascularization, Pathologic, Predictive Value of Tests, Prospective Studies, Severity of Illness Index, Young Adult, Endometriosis blood, Hypoxia-Inducible Factor 1, alpha Subunit blood, Receptor, TIE-2 blood, fas Receptor blood
- Abstract
Study Objective: To evaluate serum values of cluster of differentiation 95 (CD95/FAS), hypoxia-inducible factor 1-alpha (HIF-1α), and tyrosine kinase receptor 2 (Tie-2) as possible biomarkers of disease presence and severity in women with endometriosis, and to characterize the changes in these values in women with stage I/II and stage III/IV endometriosis., Design: Prospective study (Canadian Task Force classification I)., Setting: University hospital., Patients: Thirty women with endometriosis and 30 healthy women without endometriosis., Intervention: For the diagnosis of endometriosis and prediction of its severity, we measured the serum levels of CD95/FAS, which assess apoptotic conditions, and of HIF-1α and Tie-2, which assess angiogenesis. Endometriosis was diagnosed and staged through surgical laparoscopy and later confirmed histologically. During the surgery, the patients with endometriosis were divided into 2 groups based on disease stage. Eleven patients had stage I/II endometriosis, and 19 had stage III/IV endometriosis., Measurements and Main Results: Endometriosis was associated with increased serum CD95/FAS and HIF-1α levels, but not Tie-2 levels. We also determined that stage III/IV endometriosis was associated with higher serum CD95/FAS and HIF-1α levels, but not Tie-2 levels, compared with stage I/II endometriosis., Conclusion: Endometriosis, in accordance with its severity, increases serum CD95/FAS and HIF-1α levels, but not Tie-2 levels. These biomarkers may be useful for reproductive surgeons to improve the quality of counseling women about the presence and severity of endometriosis., (Copyright © 2016 AAGL. Published by Elsevier Inc. All rights reserved.)
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- 2016
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27. Evaluation of Maternal Serum 25-Hydroxyvitamin D, Paraoxonase 1 Levels, and Neutrophil-to-Lymphocyte Ratio in Spontaneous Preterm Birth.
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Bozoklu Akkar O, Sancakdar E, Karakus S, Yildiz C, Akkar I, Arslan M, Sahin IO, Imir Yenicesu AG, and Cetin A
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- Adult, Biomarkers blood, Female, Humans, Lymphocytes metabolism, Neutrophils metabolism, Pregnancy, Vitamin D blood, Aryldialkylphosphatase blood, Obstetric Labor, Premature blood, Premature Birth blood, Vitamin D analogs & derivatives
- Abstract
BACKGROUND The aim of this study was to evaluate the association of maternal serum 25-hydroxyvitamin D, paraoxonase 1, and neutrophil-to-lymphocyte ratio in women having early spontaneous preterm birth without clinical chorioamnionitis. MATERIAL AND METHODS This study was prospectively administered in women referred to our obstetrics service with preterm labor that resulted in preterm birth (n=35) and term labor that ended in term birth (n=44). The maternal serum levels of 25-hydroxyvitamin D and paraoxonase 1 were measured and neutrophil-to-lymphocyte ratio was calculated. RESULTS The 25-hydroxyvitamin D and paraoxonase 1 levels of the preterm group were significantly lower than those of the term group (p<0.05). The neutrophil-to-lymphocyte ratio value of the preterm group was significantly higher than that of the term group (p<0.05). There was a significant but small positive correlation between the serum levels of 25-hydroxyvitamin D and paraoxonase 1 in the preterm group (r=0.35; p=0.021). CONCLUSIONS Decreased maternal serum 25-hydroxyvitamin D and paraoxonase 1 levels and increased neutrophil-to-lymphocyte ratio may have a role in the etiology of spontaneous preterm birth.
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- 2016
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28. Angiotensin-Converting Enzyme (ACE) I/D and Alpha-Adducin (ADD1) G460W Gene Polymorphisms in Turkish Patients with Severe Chronic Tinnitus.
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Yuce S, Sancakdar E, Bağcı G, Koc S, Kurtulgan HK, Bağcı B, Doğan M, and Uysal İO
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- Adult, Aged, Chronic Disease, Female, Genetic Predisposition to Disease genetics, Humans, Male, Middle Aged, Reference Values, Tinnitus diagnosis, Turkey, Alleles, Calmodulin-Binding Proteins genetics, Genotype, INDEL Mutation genetics, Peptidyl-Dipeptidase A genetics, Polymorphism, Genetic genetics, Tinnitus genetics
- Abstract
Objective: Tinnitus is described as a disturbing sound sensation in the absence of external stimulation. We aimed to investigate whether there is any relationship between severe chronic tinnitus and angiotensin-converting enzyme (ACE) I/D and α-adducin (ADD1) G460W gene polymorphisms., Materials and Methods: The patient group and control group consisted of 89 and 104 individuals, respectively. The evaluation of tinnitus was performed using the Strukturiertes Tinnitus-Interview (STI). The Tinnitus Handicap Inventory (THI) was used to evaluate the tinnitus severity. Polymerase chain reaction (PCR) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques were used for genotyping., Results: With regard to the ACE I/D polymorphism, there was no significant difference in genotype and allele frequencies between the patient group and control group. However, a statistically significant difference was found in genotype (p<0.01) and allele frequencies (p=0.021) of the ADD1 G460W gene polymorphism. Combined genotype analysis showed that the ACE II /ADD1 GW genotype was statistically significantly higher in the patient group than in the control group (X2: 7.15, p=0.007). The odds ratio value of the GW genotype was 2.5 (95% CI=1.4-4.7) (p<0.01)., Conclusion: Our results demonstrate an association between ADD1 G460W gene polymorphism and susceptibility to severe chronic tinnitus. It was found that the GW genotype increased the disease risk by 2.5-fold compared with other genotypes. This indicates that ADD1 G460W polymorphism could be an important factor in the pathophysiology of tinnitus.
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- 2016
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29. Renalase gene polymorphism is associated with increased blood pressure in preeclampsia.
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Bagci B, Karakus S, Bagci G, and Sancakdar E
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- Adult, Amplified Fragment Length Polymorphism Analysis, Case-Control Studies, Female, Gene Frequency, Genetic Markers, Genotype, Genotyping Techniques, Humans, Pre-Eclampsia physiopathology, Pregnancy, Blood Pressure genetics, Genetic Predisposition to Disease, Monoamine Oxidase genetics, Polymorphism, Single Nucleotide, Pre-Eclampsia genetics
- Abstract
Background: Renalase is a novel enzyme that degrades circulating catecholamines. We aimed to investigate the role of rs2576178 and rs10887800 polymorphisms of the renalase gene in preeclampsia (PE) patients, Methods: This case-control study consisted of 110 women with PE and 102 normotensive controls. PCR-RFLP method was used for determination of renalase gene polymorphisms., Results: Allele frequency and genotype distribution of rs10887800 polymorphism were found statistically significantly higher in women with PE (p<0.05). Also G allele and GG genotype of rs10887800 polymorphism were found higher in women with severe PE than that of mild PE (p<0.05). There was no significant difference for rs2576178 polymorphism in terms of allele frequency and genotype distribution (p>0.05). In PE patients, systolic blood pressure (SBP) means according to rs10887800 genotypes were found statistically significantly higher (GG vs AA; p=0.001) and (GG vs GA; p=0.001). Similarly, diastolic blood pressure (DBP) means were found statistically significantly higher in PE patients (GG vs GA: p=0.001); (GG vs AA: p=0.004). For rs2576178 polymorphism, SBP means were found as (GG vs AA; p=0.012, GG vs GA; p>0.05) in PE patients. DBP means were not significant according to rs2576178 genotypes in PE patients (p>0.05)., Conclusions: The findings of the present study suggest that blood pressure may be increased by GG genotype and G allele of rs10887800 polymorphism and the polymorphism may increase the susceptibility to PE., (Copyright © 2016 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.)
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- 2016
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30. Serum levels of ET-1, M30, and angiopoietins-1 and -2 in HELLP syndrome and preeclampsia compared to controls.
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Karakus S, Bozoklu Akkar O, Yildiz C, Sancakdar E, Cetin M, and Cetin A
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- Adult, Biomarkers blood, Case-Control Studies, Cross-Sectional Studies, Female, Fetal Blood chemistry, Gravidity, HELLP Syndrome blood, Humans, Parity, Pre-Eclampsia blood, Pregnancy, Pregnant Women, Angiopoietin-1 blood, Angiopoietin-2 blood, Endothelin-1 blood, HELLP Syndrome diagnosis, Keratin-18 blood, Peptide Fragments blood, Pre-Eclampsia diagnosis
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Purpose: We aimed to compare the serum levels of ET-1, M30, and Angs-1 and -2 in patients with preeclampsia or HELLP syndrome, and normal controls., Methods: In this cross-sectional study of 74 pregnant women, serum levels of ET-1, M30, and Angs-1 and -2 were measured in preeclamptic patients with or without HELLP syndrome. 74 pregnant women; 37 had healthy pregnancies, 25 had preeclampsia (PE), and 12 had HELLP syndrome., Results: The age, body mass index, gravidity, and parity of patients with normal pregnancy, PE, and HELLP syndrome were comparable (p > 0.05). In HELLP syndrome, compared to healthy or preeclamptic pregnancies, platelet count was lower (p < 0.05) and the values of hepatic function tests were higher (p < 0.05). In HELLP syndrome, ET-1, M30, and Ang-2 were higher compared to healthy or preeclamptic pregnancies (p < 0.05); however, they increased in preeclamptic pregnancies compared to healthy pregnancies though not significant (p > 0.05). In PE or HELLP syndrome, Ang-1 was higher compared to a healthy pregnancy (p < 0.05); however, in HELLP syndrome, it was also higher than in PE though not significant (p > 0.05). We found no significant correlation among these biomarkers and hematological and biochemical parameters (p > 0.05)., Conclusion: For the diagnosis of HELLP syndrome, increased levels of ET-1, M30, and Angs-1 and -2 appear as promising biomarkers after determination of their standardized threshold levels after further studies. As an apoptosis-related biomarker, serum M30 level has a merit to be the most promising test for prediction or differential diagnosis of HELLP syndrome in PE patients.
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- 2016
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31. Important of Angiopoietic System in Evaluation of Endothelial Damage in Children with Crimean-Congo Hemorrhagic Fever.
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Sancakdar E, Guven AS, Uysal EB, Deveci K, and Gültürk E
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- Adolescent, Case-Control Studies, Child, Female, Hemorrhagic Fever, Crimean blood, Humans, Male, ROC Curve, Angiopoietin-2 blood, Hemorrhagic Fever, Crimean epidemiology, Hemorrhagic Fever, Crimean physiopathology, Receptor, TIE-2 blood, Vascular Endothelial Growth Factor A blood
- Abstract
Background: Crimean-Congo hemorrhagic fever (CCHF) causes endothelial activation and dysfunction by affecting the endothelium directly or indirectly. In maintaining the vascular integrity, vascular endothelial growth factor (VEGF-A) and its receptor (VEGFR1) and angiopoietin-2 (Ang-2) and its receptor (Tie-2) are very important mediators. For this reason, we aimed at studying the association of Ang-2 and VEGF and their receptors Tie-2 and VEGFR1 with CCHF infection., Methods: Thirty one CCHF patients and 31 healthy controls (HC) were included in the study. CCHF patients were classified into 2 groups in terms of disease severity (severe and nonsevere). VEGF-A, VEGFR1, Ang-2 and Tie-2 levels were measured in all groups., Result: Serum levels of Tie-2, Ang-2, VEGF-A and VEGFR1 were significantly increased in CCHF patients compared with the HC. Furthermore, serum Tie-2, Ang-2, VEGF and VEGFR1 levels were found to be significantly higher in the severe group than in the nonsevere and HC groups (P < 0.05 and P < 0.001, respectively). Also, Tie-2, Ang-2, VEGF-A and VEGFR1 levels were significantly higher in the nonsevere group than in the HC group (P < 0.05)., Conclusion: Having statistically significant higher Ang-2, Tie-2, VEGF-A and VEGFR1 levels in the severe group when compared with the other groups suggested that VEGF-related Ang-2/Tie-2 system played a critical role in the pathogenesis of the disease, and these markers could be used as the severity criteria.
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- 2015
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32. Evaluation of endothelium functions by flow-mediated dilatation in pediatric patients with Crimean-Congo hemorrhagic fever.
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Karapinar H, Kaya A, Uysal EB, Küçükdurmaz Z, Deveci K, Güven AS, Sancakdar E, and Yilmaz A
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- Adolescent, Brachial Artery physiology, Child, Female, Humans, Male, Prospective Studies, Thrombocytopenia pathology, Dilatation, Endothelium, Vascular physiology, Hemorrhagic Fever, Crimean pathology
- Abstract
Background: Crimean-Congo hemorrhagic fever (CCHF) is a systemic viral disease that also affects the endothelium. Thrombocytopenia and hemorrhage are seen in this disease. But, the cause of thrombocytopenia is not clear. We hypothesized that endothelium dysfunction may be the cause of thrombocytopenia. We evaluated the endothelium functions by flow-mediated dilatation (FMD) in CCHF., Methods: Consecutive children with suspected CCHF who applied to our hospital were evaluated for recruitment into the study. FMD analysis was done in the active and healing period of the disease. Diagnosis was confirmed or ruled out by polymerase chain reaction and/or ELISA test. Basal brachial artery diameter (BBAD) and dilated brachial artery diameter (DBAD) after ischemic period were measured and percent dilatations [(DBAD-BBAD)/BBAD, FMD%] were computed from all subjects., Results: Fifty-four children (40 male, mean age 12.4 ± 4.4 years) were recruited into the study. CCHF diagnosis was confirmed in 28 children and ruled out in 26 children. Groups were similar for age and gender. FMD% was significantly decreased in CCHF patients when comparing this with the control patients in the active period (2.65 ± 2.76 vs. 13.76 ± 7.95, P < 0.001). FMD% was correlated with platelet count in the active period of the disease (r = 0.599, P = 0.004). FMD% was recovered in the healing period (2.65 ± 2.76 vs. 14.72 ± 2.66, P < 0.001) and was not significantly different from basal values of control patients (P > 0.05)., Conclusions: FMD is significantly decreased in CCHF and recovers in the healing period. So, endothelium functions are disturbed, and disturbance is correlated with thrombocytopenia in CCHF.
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- 2015
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33. Alterations of serum brain type natriuretic peptide (BNP) in patients with Crimean-Congo hemorrhagic fever.
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Uysal EB, Sancakdar E, Şeker A, Deveci K, Tuzcu N, and Karapınar H
- Abstract
Background: Crimean-Congo hemorrhagic fever (CCHF) is known to be associated with cardiac damage. Brain type natriuretic peptide (BNP) is secreted from stressed myocardium., Objectives: This study investigated that BNP levels in CCHF and its association with clinical course of disease., Methods: Consecutive CCHF diagnosis confirmed patients were enrolled to the study. Results of patients were compared with age-sex-matched healthy volunteers. Blood samples for BNP levels were collected from the patients during emergency room applications. Mortality, hospitalization duration and other disease severity predictors (thrombocyte count, hemoglobin, white blood cell count, alanine aminotransferase, aspartate aminotransferase, prothrombin time, lactate dehydrogenase, international normalized ratio, activated partial thromboplastin time) were recorded. These parameters' correlations with BNP levels were analyzed., Result: Forty-three CCHF patients and 28 control subjects recruited to the study. Groups were similar for age and gender. There was no mortality. Levels of BNP were found to be significantly higher in patients than control subjects (100.4±45.4 vs. 78.0±40.4, P=0.033). But BNP levels were not correlated with duration of hospitalization and disease severity predictors (P > 0.05)., Conclusions: This study showed that BNP levels are modestly increased in CCHF but this increase does not correlated with disease severity predictors.
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- 2015
34. Evaluation of serum perforin, caspase-3, sFasL and M-30 levels as apoptotic markers in children with Crimean-Congo hemorrhagic fever.
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Güven AS, Sancakdar E, Uysal EB, Kaya A, Oflaz MB, Karapınar H, Bolat F, Tuzcu N, Deveci K, Cevit Ö, and İcagasioglu FD
- Subjects
- Biomarkers blood, Child, Humans, Serum chemistry, Severity of Illness Index, Apoptosis, Caspase 3 blood, Fas Ligand Protein blood, Hemorrhagic Fever, Crimean immunology, Hemorrhagic Fever, Crimean pathology, Keratin-18 blood, Perforin blood
- Abstract
Background: Apoptosis is a main regulator in responses of cellular immunity throughout systemic viral infections. Perforin, soluble Fas ligand, caspase-3 and caspase-cleaved cytokeratin-18 (M-30) are mediators of apoptosis. The aim of this study is the evaluation of Crimean-Congo hemorrhagic fever (CCHF) disease changes in the levels of these apoptotic markers and the relation of these changes with disease severity., Methods: Forty-nine hospitalized children with CCHF and 36 healthy controls were enrolled in this prospective study. The CCHF patients were classified into 2 groups based on disease severity (severe group and nonsevere group). Demographic characteristics and clinical and laboratory findings of all patients were recorded on admission., Results: Serum perforin, caspase-3 and soluble Fas ligand levels were found to be significantly higher both in the severe and nonsevere CCHF groups than the healthy control group (P < 0.05), but there was no significant difference in these apoptotic markers between severe and nonsevere CCHF groups (P > 0.05). In addition, serum M-30 levels did not differ significantly among all groups (P > 0.05). There was a positive correlation between serum values for perforin, caspase-3 and M-30 and the disease's severity criteria such as aspartate aminotransferase and/or alanine aminotransferase. The serum levels of all these markers were negatively correlated with disease severity criteria such as the platelet count., Conclusions: In this study, we concluded that the interactions of cytolytic granules containing perforin and caspase cascade and Fas-FasL may play an important role in the pathogenesis of CCHF in children.
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- 2015
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35. Predictive role of neutrophil gelatinase-associated lipocalin in early diagnosis of platin-induced renal injury.
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Seker MM, Deveci K, Seker A, Sancakdar E, Yilmaz A, Turesin AK, Kacan T, and Babacan NA
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- Acute Kidney Injury chemically induced, Acute Kidney Injury urine, Adult, Aged, Capecitabine administration & dosage, Carboplatin administration & dosage, Cisplatin administration & dosage, Creatinine urine, Deoxycytidine administration & dosage, Deoxycytidine analogs & derivatives, Docetaxel, Female, Fluorouracil administration & dosage, Follow-Up Studies, Humans, Lipocalin-2, Male, Middle Aged, Neoplasm Metastasis, Neoplasm Staging, Neoplasms complications, Neoplasms pathology, Organoplatinum Compounds administration & dosage, Oxaliplatin, Paclitaxel, Prognosis, Taxoids administration & dosage, Gemcitabine, Acute Kidney Injury diagnosis, Acute-Phase Proteins urine, Antineoplastic Combined Chemotherapy Protocols adverse effects, Biomarkers, Tumor urine, Lipocalins urine, Neoplasms drug therapy, Proto-Oncogene Proteins urine
- Abstract
Background: Acute kidney injury is an important issue in chemotherapy receiving patients an neutrophil gelatinase-associated lipocalin has been proposed as a novel marker. We here aimed to assess the role of urinary levels for assessment after platin exposure., Materials and Methods: Patients who had treated with cisplatin or carboplatin or oxaliplatin containg regimens were included in this study. Baseline and postchemotherapy serum urea, creatinine, urine neutrophil gelatinase-associated lipocalin and urine creatinine levels were determined. To avoid the effects of hydration during chemotherapy infusion the urinary neutrophil gelatinase-associated lipocalin/urine creatinine ratio was used to determine acute kidney injury., Results: Of a total of 42 patients receiving platin compounds,14 (33.3%) received cisplatin containing regimens, 14 (33.3%) received carboplatin and 14 (33.3%) oxaliplatin. The median age was 60 (37-76) years. Nineteen of the patients (45.2%) had lung cancer, 12 (28.6%) colorectal cancer and 11 (26.2%) others. The median pre and post chemotherapy urine neutrophil gelatinase-associated lipocalin/urine creatinin ratio was 15.6 ng/mg and 35.8 ng/mg (p=0.041) in the cisplatin group, 32.5 ng/mg and 86.3 ng/mg (p=0.004) in the carboplatin group and 40.9 ng/mg and 62.3 ng/ mg (p=0.243) in the oxaliplatin group., Conclusions: Nephrotoxicity is a serious side effect of chemotherapeutic agentslike cisplatin and carbopaltin, but only to a lower extent oxaliplatin. All platin compounds must be used carefully and urine neutrophil gelatinase-associated lipocalin measurement seems to be promising in detecting acute kidney injury earlier than with creatinine.
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- 2015
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36. The effects of sildenafil in liver and kidney injury in a rat model of severe scald burn: a biochemical and histopathological study.
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Gökakın AK, Atabey M, Deveci K, Sancakdar E, Tuzcu M, Duger C, and Topcu O
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- Animals, Female, Kidney injuries, Kidney pathology, Lipid Peroxidation drug effects, Liver injuries, Liver pathology, Malondialdehyde metabolism, Models, Animal, Oxidative Stress drug effects, Random Allocation, Rats, Rats, Wistar, Sildenafil Citrate administration & dosage, Tumor Necrosis Factor-alpha metabolism, Vascular Endothelial Growth Factor A metabolism, Vasodilator Agents administration & dosage, Burns pathology, Inflammation prevention & control, Sildenafil Citrate therapeutic use, Soft Tissue Injuries pathology, Vasodilator Agents therapeutic use
- Abstract
Background: Severe burn induces systemic inflammation and reactive oxygen species leading to lipid peroxidation which may play role in remote organs injury. Sildenafil is a selective and potent inhibitor of cyclic guanosine monophosphate specific phosphodiesterase-5. Sildenafil reduces oxidative stress and inflammation in distant organs. The aim of the present study was to evaluate the effects of different dosages of sildenafil in remote organs injury., Methods: A total of thirty-two rats were randomly divided into four equal groups. The groups were designated as follows: Sham, Control, 10, and T20 mg/kg sildenafil treatment groups. Levels of malondialdehyde (MDA), vascular endothelial growth factor (VEGF), VEGF receptor (Flt-1), activities of glutathione peroxidase (Gpx), levels of total antioxidative capacity (TAC), and total oxidant status (TOS) were measured in both tissues and serum, and a semi-quantitative scoring system was used for the evaluation of histopathological findings., Results: Sildenafil increased levels of Gpx, and Flt-1, and decreased MDA and VEGF levels in tissues. Sildenafil also increased serum levels of TAC and Flt-1 and decreased TOS, OSI, and VEGF., Conclusion: Sildenafil decreased inflammation scores in remote organs in histopathological evaluation. It has protective effects in severe burn-related remote organ injuries by decreasing oxidative stress and inflammation.
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- 2014
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37. Evaluation of the serum levels of soluble IL-2 receptor and endothelin-1 in children with Crimean-Congo hemorrhagic fever.
- Author
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Deveci K, Oflaz MB, Sancakdar E, Uysal EB, Guven AS, Kaya A, Alkan F, and Cevit O
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- Child, Child, Preschool, Female, Humans, Lymphocyte Activation immunology, Lymphohistiocytosis, Hemophagocytic pathology, Male, Platelet Activation immunology, Platelet Count, Prognosis, Turkey, Endothelin-1 blood, Hemorrhagic Fever, Crimean blood, Hemorrhagic Fever, Crimean immunology, Receptors, Interleukin-2 blood, T-Lymphocytes immunology
- Abstract
We aimed to assess the association between serum levels of soluble IL-2 receptor (sIL-2r) and endothelin-1 and severe infection in children with Crimean-Congo hemorrhagic fever (CCHF). Fifty-two patients under 18 years of age with a laboratory- confirmed diagnosis of CCHF and 38 healthy controls were enrolled in the study. Patients were classified into two groups based on disease severity (severe group and non-severe group). The sIL-2r and endothelin-1 levels were observed to be significantly higher in patients with severe CCHF compared with those with non-severe CCHF and the control group (p < 0.05). In addition, those with non-severe CCHF were also found to have a significantly higher sIL-2r level relative to the control group (p < 0.001). Although there was a positive correlation between sIL-2r and endothelin-1 levels, serum levels of both sIL-2r and endothelin-1 were negatively correlated with the platelets count. In children with CCHF, serum levels of sIL-2r and endothelin-1 were increased, and this increase is related to the severity of the disease. In this study, we concluded through prognosis that serum levels of sIL-2r and endothelin-1 might be related, and that hemophagocytic lymphohistiocytosis and endothelial injury might contribute to a pathogenesis of the disease., (© 2013 APMIS. Published by John Wiley & Sons Ltd.)
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- 2014
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38. Do neutrophil gelatinase-associated lipocalin and interleukin-18 predict renal dysfunction in patients with familial Mediterranean fever and amyloidosis?
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Deveci K, Korkmaz S, Senel S, Deveci H, Sancakdar E, Uslu AU, Deniz A, Alkan F, Seker MM, and Sencan M
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- Acute-Phase Proteins urine, Adult, Amyloidosis blood, Amyloidosis urine, Biomarkers blood, Biomarkers urine, Familial Mediterranean Fever blood, Familial Mediterranean Fever urine, Female, Glomerular Filtration Rate, Humans, Interleukin-18 blood, Interleukin-18 urine, Lipocalin-2, Lipocalins blood, Lipocalins urine, Male, Middle Aged, Prospective Studies, Proto-Oncogene Proteins blood, Proto-Oncogene Proteins urine, Acute-Phase Proteins metabolism, Amyloidosis physiopathology, Familial Mediterranean Fever physiopathology, Interleukin-18 metabolism, Kidney physiopathology, Lipocalins metabolism, Proto-Oncogene Proteins metabolism
- Abstract
Background: The aim of this study was to evaluate whether neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) predict renal disfunction in patients with familial Mediterranean fever (FMF)., Methods: This prospective study consisted of 102 patients with FMF in attack-free period, and 40 matched healthy controls. Of the patients, nine were diagnosed as amyloidosis. The patients were divided into two groups according to eGFR as below 120 mL per minute and above 120 mL per minute. Also, patients were divided into three groups according to the degree of urinary albumin excretion as normoalbuminuric, microalbuminuric, and macroalbuminuric. The serum levels of IL-18 (sIL-18) and NGAL (sNGAL), and urinary levels of IL-18 (uIL-18) and NGAL (uNGAL) were measured by using ELISA kits., Results: The levels of sIL-18, sNGAL, uIL-18, and uNGAL were detected significantly higher in FMF patients, particularly in patients with amyloidosis, when compared to controls. sNGAL, uIL-18, and uNGAL were significantly higher in patients with eGFR < 120 mL per minute than in patients with eGFR ≥ 120 mL per minute. sNGAL, uIL-18, and uNGAL were correlated significantly with urinary albumin excretion, additionally, were inverse correlated with eGFR. The most remarkable findings of this study are of the higher values of sIL-18, sNGAL, uIL-18, and uNGAL in both normoalbuminuric FMF patients and patients with eGFR ≥ 120 mL per minute., Conclusions: The results of this study suggest that sIL-18, uIL-18, sNGAL, and uNGAL are reliable markers of early renal disfunction in FMF patients, and may let us take measures from the early stage of renal involvement.
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- 2014
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39. Evaluation of cytokines as Th1/Th2 markers in pathogenesis of children with Crimean-Congo hemorrhagic fever.
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Sancakdar E, Güven AS, Uysal EB, Kaya A, Deveci K, Karapınar H, and Akkar I
- Abstract
Cytokine networks play a key role in the pathogenesis of the disease in Crimean-Congo Hemorrhagic Fever (CCHF) patients. Therefore, our aim was to study the effects of cytokine levels on the pathogenesis and severity of the disease in children with CCHF. Fifty-two patients diagnosed with CCHF and 34 healthy controls (HC) were included in the study. The patients with CCHF were divided into two groups (severe and non-severe). The levels of the Interleukin-10 (IL-10), IL-12, IL-6, Endothelin-1 (ET-1) and tumor necrosis factor-α (TNF-α) were measured in all groups. IL-12 levels did not show any difference between the CCHF and HC groups and among the severe, non-severe and HC groups. IL-10 and ET-1 levels were significantly higher in the severe group when compared to the non-severe group and the HC group. Moreover, IL-10 and ET-1 levels were significantly higher in the non-severe group when compared to the HC group. In terms of IL-6 and TNF-α levels, there was no difference between the severe and non-severe groups while the said levels were significantly higher in the severe group when compared to the HC group. The results of the present study showing significantly higher IL-10 and ET-1 levels in the severe group suggest that Th2-mediated humoral immunity is more effective in the pathogenesis and severity of CCHF in children.
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- 2014
40. Value of ABO blood group in predicting the severity of children with Crimean-Congo hemorrhagic fever.
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Güven AS, Sancakdar E, Kaya A, Uysal EB, Oflaz MB, Bolat F, Karapınar H, Koç E, and Icagasioglu FD
- Abstract
Purpose: The aim of this study was to assess the role of ABO blood groups in predicting disease severity and bleeding potential in children with Crimean-Congo hemorrhagic fever (CCHF)., Methods: One hundred fifty-one hospitalized patients with CCHF were enrolled in this retrospective study. The patients were divided according to O- and non-O- (A, B and AB) blood groups (n=91 and n=60, respectively). They were also classified into two groups (severe and non-severe) based on disease severity (n=29 and n=122, respectively). Demographic characteristics, clinical findings, and hematologic and biochemical parameters of all patients were recorded on admission and discharge., Results: Although, in all cases, compared to the non-O blood group, the ratio of the blood group O was considerably higher (60% vs. 40%) and similarly so in severe cases (58.6% vs. 41.4%), this difference was not statistically significant (p>0.05). The aPTT at discharge and fever duration of the O-blood group were significantly higher than those of the non-O-blood group (p=0.042, p=0.034, respectively). The factor VIII level of the O-blood group was significantly lower than that of the non-O-blood group (p=0.040). Although the ratios of bleeding and severity were higher in the O-blood group compared to the other group, statistical significance was not reached (p>0.05)., Conclusions: Consideration of the ABO blood group is important during diagnostic follow-up to assess the severity of CCHF. In clinical practice, pediatric CCHF patients with the O blood group need to be followed closely for tendency to bleed.
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- 2014
41. Evaluation of complement system in children with Crimean-Congo hemorrhagic fever.
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Sancakdar E, Uysal EB, Güven AS, Kaya A, Filiz AK, Acibucu DO, Deveci K, and Seker MM
- Subjects
- Adolescent, Biomarkers blood, Child, Female, Humans, Male, Complement System Proteins metabolism, Hemorrhagic Fever, Crimean blood, Hemorrhagic Fever, Crimean diagnosis
- Abstract
Objectives: The complement system participates in the defense of the body against viral infections through various mechanisms. In the present study conducted on children having Crimean-Congo Hemorrhagic Fever (CCHF), the aim was to evaluate whether the complement system had a role in the pathogenesis of the disease., Patients and Methods: Forty-one patients diagnosed with CCHF and 32 healthy controls were included in the study. Serum complement component 3 (C3), 4 (C4) and complement product Bb (Bb) levels were measured in both groups., Results: Compared to the control group, serum C3 levels were lower and Bb levels were higher in CCHF patients (p < 0.01). Moreover, in the patient group, C3 levels were positively correlated with WBC and PLT counts, and Bb levels were positively correlated with AST, ALT and LDH activities. In the patient group, serum Bb levels were negatively correlated with WBC and PLT counts., Conclusions: The results of the present study suggest that increased activity of the alternative pathway of the complement system in children with CCHF may have a role in the pathogenesis of the disease.
- Published
- 2014
42. Red cell distribution width and hypertensive response to exercise in patients with type 2 diabetes mellitus.
- Author
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Kucukdurmaz Z, Karavelioglu Y, Karapinar H, Sancakdar E, Deveci K, Gul I, and Yilmaz A
- Subjects
- Adult, Blood Pressure physiology, Blood Pressure Monitoring, Ambulatory, Case-Control Studies, Diabetes Mellitus, Type 2 complications, Exercise Test, Female, Humans, Hypertension complications, Logistic Models, Male, Middle Aged, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 physiopathology, Erythrocyte Indices physiology, Exercise physiology, Hypertension blood, Hypertension physiopathology
- Abstract
Objective: There is no study about hypertensive response to exercise (HRE), which is a marker of unborn hypertension (HT), and red cell distribution width (RDW) association, in diabetic normotensive patients. So, we aimed to investigate any correlation among RDW and HRE in normotensive type 2 diabetic patients., Methods: Consecutive type 2 diabetic patients without history of HT and with normal blood pressure (BP) on ambulatory BP monitoring were included to the study. We divided the patients into two groups depending on their peak systolic BP on exercise; HRE (Group 1) or normal response to exercise (Group 2)., Results: Data of 75 diabetic patients (51.9 ± 9.7) were analyzed (31 male (48%)). Their mean RDW was 13.11 ± 0.46. Patients with HRE were significantly older than patients without HRE. Smoking was more frequent in Group 2. Gender distribution and body mass index were similar between the groups. Else hemoglobin, hematocrit, red blood cell count and RDW values were not significantly different. Office systolic BP and diastolic BP, daytime and 24-h systolic BP were significantly higher in Group 1 but heart rate was similar between the groups., Conclusions: This study revealed that RDW do not differ between diabetic normotensive patients with HRE or not.
- Published
- 2014
- Full Text
- View/download PDF
43. Evaluation of nasal mucociliary activity in iatrogenic hypothyroidism.
- Author
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Uysal IO, Gökakın AK, Karakuş CF, Deveci K, Hasbek Z, and Sancakdar E
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Saccharin, Thyroid Neoplasms surgery, Thyroidectomy, Time Factors, Hypothyroidism physiopathology, Iatrogenic Disease, Mucociliary Clearance physiology, Nasal Mucosa physiopathology
- Abstract
Our aim was to evaluate the effects of iatrogenic, acute and deep hypothyroidism on nasal mucociliary clearance. A total of 46 patients undergoing total or near total thyroidectomy for differentiated thyroid cancer between March and June 2012, and scheduled to undergo radioactive iodine (I-131) ablation therapy followed with an induced hypothyroidism for routine screening were included in the study. Mucociliary clearance test was made during hypothyroid and euthyroid periods in all the patients included in the study. Of the 46 patients included in the study, 37 (%80.4) were females, 9 (%19.6) were males, and the average mucociliary clearance times were 16.78 and 9.58 min during hypothyroid and euthyroid periods, respectively. When the results were compared statistically, mucociliary clearance time measured during hypothyroidism period was found to be significantly longer than the one measured during euthyroid period. Mucociliary clearance time was found to be long during iatrogenic acute and deep hypothyroid periods. During these periods, patients should be followed closely for lower and upper respiratory tract infections.
- Published
- 2013
- Full Text
- View/download PDF
44. Bradycardia seen in children with Crimean-Congo hemorrhagic fever.
- Author
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Oflaz MB, Kucukdurmaz Z, Guven AS, Karapinar H, Kaya A, Sancakdar E, Deveci K, Gul I, Erdem A, Cevit O, and Icagasioglu FD
- Subjects
- Adolescent, Animals, Bradycardia complications, Bradycardia drug therapy, Bradycardia epidemiology, Child, Child, Preschool, Female, Hemorrhagic Fever, Crimean complications, Hemorrhagic Fever, Crimean drug therapy, Hemorrhagic Fever, Crimean epidemiology, Hemorrhagic Fever, Crimean virology, Humans, Infant, Infant, Newborn, Male, Risk Factors, Sex Factors, Tick Bites, Turkey epidemiology, Antibodies, Viral blood, Bradycardia physiopathology, Hemorrhagic Fever Virus, Crimean-Congo immunology, Hemorrhagic Fever, Crimean physiopathology
- Abstract
Introduction: Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic viral disease with a high mortality rate. In clinical practice, we observed bradycardia in some pediatric patients with CCHF during the clinical course. So we aimed to report CCHF cases that presented bradycardia during the clinical course and the relation of bradycardia with the clinical findings and ribavirin therapy., Methods: Charts of all hospitalized pediatric CCHF patients were reviewed with respect to age, sex, history of tick bite or history of removing a tick, other risk factors for CCHF transmission, and interval between the tick bite and the onset of symptoms. Outcomes and clinical and laboratory findings and medications were recorded for each patient. We searched the patient records for information regarding the existence of bradycardia. Bradycardia was accepted as the heart rate 2 standard deviations (SD) lower than the suspected heart rate based on age., Results: Fifty-two patients (mean age 11.2 ± 4.4 years, 31 female) were enrolled into the study. Bradycardia was seen in seven patients. Six patients with bradycardia were male and only one was female, and the mean age was 13.1 ± 1.6 years. It was observed that male gender is frequent among patients with bradycardia, as compared with those without bradycardia (p=0.01). Bleeding was found to be more frequent in patients with bradycardia (p=0.02). There were significant differences between the bradycardia and nonbradycardia groups with regard to the requirements for fresh frozen plasma transfusion, the number of platelet suspension given, requirement for intravenous immune globulin (IVIG) and in the days of stay in hospital (p=0.01, p=0.03, p=0.03, p=0.04, respectively)., Conclusion: Reversible bradycardia might be seen in the clinical course of pediatric CCHF patients, and the clinicians must be aware of this finding. The possibility that ribavirin may potentiate bradycardia cannot be assessed without a placebo-control study. So further studies may help to reveal the cause of the bradycardia, the disease itself, or the ribavirin therapy. Hence this study supports the need for a randomized, placebo-controlled study to assess intravenous ribavirin in treating CCHF and to support approval of the drug.
- Published
- 2013
- Full Text
- View/download PDF
45. Evaluation of renal involvement in children with Crimean-Congo hemorrhagic fever.
- Author
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Deveci K, Uysal EB, Kaya A, Sancakdar E, and Alkan F
- Subjects
- Acute-Phase Proteins urine, Adolescent, Case-Control Studies, Child, Child, Preschool, Cohort Studies, Female, Hemorrhagic Fever, Crimean urine, Humans, Kidney Diseases physiopathology, Kidney Diseases urine, Lipocalin-2, Lipocalins urine, Male, Proteinuria microbiology, Proteinuria physiopathology, Proteinuria urine, Proto-Oncogene Proteins urine, Turkey, Hemorrhagic Fever, Crimean physiopathology, Kidney Diseases microbiology
- Abstract
The aim of the present study was to evaluate renal involvement in children with Crimean-Congo hemorrhagic fever (CCHF). Forty-four children infected with CCHF virus and 30 controls were enrolled in the study. Urine neutrophil gelatinase-associated lipocalin (uNGAL) and urine protein levels were measured in the patient and control groups. Clinical and laboratory findings of the patient and control groups were compared. uNGAL levels were higher in the patient group than that in the control group (P < 0.001). Of the 44 patients, 26 (59.1%) were proteinuric. uNGAL levels in proteinuric patients were higher than those in non-proteinuric patients (P = 0.035). There was a positive correlation between uNGAL and urine protein levels in the patient group. (R = 0.614, P < 0.001). Due to renal involvement, increased proteinuria and increased uNGAL levels were observed in children with CCHF. In these children, measuring urine total protein and uNGAL levels can be useful to monitor renal involvement due to CCHF.
- Published
- 2013
- Full Text
- View/download PDF
46. Is neutrophil/lymphocyte ratio associated with subclinical inflammation and amyloidosis in patients with familial Mediterranean fever?
- Author
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Uslu AU, Deveci K, Korkmaz S, Aydin B, Senel S, Sancakdar E, and Sencan M
- Subjects
- Amyloidosis complications, Blood Sedimentation, C-Reactive Protein metabolism, Case-Control Studies, Familial Mediterranean Fever complications, Female, Humans, Inflammation immunology, Leukocyte Count, Male, ROC Curve, Young Adult, Amyloidosis pathology, Familial Mediterranean Fever immunology, Familial Mediterranean Fever pathology, Inflammation pathology, Lymphocytes pathology, Neutrophils pathology
- Abstract
Background: The purpose of the present study is to determine the association between neutrophil/lymphocyte ratio and both subclinical inflammation and amyloidosis in familial Mediterranean fever., Methods: Ninety-four patients with familial Mediterranean fever and 60 healthy volunteers were included in the study. Of the patients, 12 had familial Mediterranean fever related amyloidosis. The neutrophil/lymphocyte ratio of the patients was obtained from the hematology laboratory archive., Results: The neutrophil/lymphocyte ratio was significantly higher among persons with familial Mediterranean fever compared to healthy individuals (P < 0.0001). Also, neutrophil/lymphocyte ratio was significantly higher in patients with amyloidosis than in amyloidosis-free patients (P < 0.0001). Since NLR was evaluated in nonamyloid and amyloid stages of the same patient population (type 1 phenotype), we obtained significant statistical differences (1.95 ± 0.30 versus 2.64 ± 0.48, P < 0.05, resp.). With the cutoff value of neutrophil/lymphocyte ratio >2.21 and AUC = 0.734 (P = 0.009), it was a reliable marker in predicting the development of amyloidosis., Conclusion: The neutrophil/lymphocyte ratio, an emerging marker of inflammation, is higher in patients with familial Mediterranean fever in attack-free periods. The neutrophil/lymphocyte ratio may be a useful marker in predicting the development of amyloidosis.
- Published
- 2013
- Full Text
- View/download PDF
47. Effects of testosterone on orchiectomy-induced oxidative damage in the rat hippocampus.
- Author
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Meydan S, Kus I, Tas U, Ogeturk M, Sancakdar E, Dabak DO, Zararsız I, and Sarsılmaz M
- Subjects
- Animals, Disease Models, Animal, Hippocampus enzymology, Male, Nerve Degeneration drug therapy, Nerve Degeneration enzymology, Neuroprotective Agents pharmacology, Oxidative Stress physiology, Rats, Rats, Wistar, Testosterone deficiency, Hippocampus drug effects, Hippocampus metabolism, Nerve Degeneration metabolism, Orchiectomy adverse effects, Oxidative Stress drug effects, Testosterone pharmacology
- Abstract
The aim of this study was to investigate the morphological changes of the hippocampus after orchiectomy and the protective effects of testosterone on these changes. Animals were divided into 3 groups. The rats in group I were used for sham-orchiectomy. Orchiectomy was performed on the rats in group II. The rats in group III were administrated testosterone propionate 0.5mg/kg/day for 30 days after the orchiectomy. Some of the hippocampal tissues were used for determination of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) enzyme activities, and malondialdehyde (MDA) levels. The remaining hippocampal tissue specimens were stained with routine histological methods and examined under the light microscope. Additionally, the samples were immunohistochemically stained by using avidin-biotin-peroxidase for determination of bax immunoreactivity. The SOD and GSH-Px enzyme activities of the hippocampus were decreased, and MDA levels were increased in group II rats compared to the sham-orchiectomy group. In the light microscopic evaluation of the tissue specimens from group II, significant increases were detected in the number of picnotic cells and in bax immunoreactivity compared to the sham-orchiectomy group. However, an increase was observed in activities of SOD and GSH-Px enzymes and a decrease of the MDA levels in animals with orchiectomy, but having externally administered testosterone. It was determined that the increase of bax immunoreactivity and histopathological changes in this group were regressed by testosterone. The results of our study revealed that orchiectomy-induced oxidative damage and morphological changes in the hippocampal tissue were suppressed by testosterone., (Copyright © 2010 Elsevier B.V. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF
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