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Serum levels of ET-1, M30, and angiopoietins-1 and -2 in HELLP syndrome and preeclampsia compared to controls.
- Source :
-
Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2016 Feb; Vol. 293 (2), pp. 351-9. Date of Electronic Publication: 2015 Jul 03. - Publication Year :
- 2016
-
Abstract
- Purpose: We aimed to compare the serum levels of ET-1, M30, and Angs-1 and -2 in patients with preeclampsia or HELLP syndrome, and normal controls.<br />Methods: In this cross-sectional study of 74 pregnant women, serum levels of ET-1, M30, and Angs-1 and -2 were measured in preeclamptic patients with or without HELLP syndrome. 74 pregnant women; 37 had healthy pregnancies, 25 had preeclampsia (PE), and 12 had HELLP syndrome.<br />Results: The age, body mass index, gravidity, and parity of patients with normal pregnancy, PE, and HELLP syndrome were comparable (p > 0.05). In HELLP syndrome, compared to healthy or preeclamptic pregnancies, platelet count was lower (p < 0.05) and the values of hepatic function tests were higher (p < 0.05). In HELLP syndrome, ET-1, M30, and Ang-2 were higher compared to healthy or preeclamptic pregnancies (p < 0.05); however, they increased in preeclamptic pregnancies compared to healthy pregnancies though not significant (p > 0.05). In PE or HELLP syndrome, Ang-1 was higher compared to a healthy pregnancy (p < 0.05); however, in HELLP syndrome, it was also higher than in PE though not significant (p > 0.05). We found no significant correlation among these biomarkers and hematological and biochemical parameters (p > 0.05).<br />Conclusion: For the diagnosis of HELLP syndrome, increased levels of ET-1, M30, and Angs-1 and -2 appear as promising biomarkers after determination of their standardized threshold levels after further studies. As an apoptosis-related biomarker, serum M30 level has a merit to be the most promising test for prediction or differential diagnosis of HELLP syndrome in PE patients.
- Subjects :
- Adult
Biomarkers blood
Case-Control Studies
Cross-Sectional Studies
Female
Fetal Blood chemistry
Gravidity
HELLP Syndrome blood
Humans
Parity
Pre-Eclampsia blood
Pregnancy
Pregnant Women
Angiopoietin-1 blood
Angiopoietin-2 blood
Endothelin-1 blood
HELLP Syndrome diagnosis
Keratin-18 blood
Peptide Fragments blood
Pre-Eclampsia diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0711
- Volume :
- 293
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Archives of gynecology and obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 26138305
- Full Text :
- https://doi.org/10.1007/s00404-015-3803-1