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Evaluation of the serum levels of soluble IL-2 receptor and endothelin-1 in children with Crimean-Congo hemorrhagic fever.
- Source :
-
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica [APMIS] 2014 Jul; Vol. 122 (7), pp. 643-7. Date of Electronic Publication: 2013 Dec 10. - Publication Year :
- 2014
-
Abstract
- We aimed to assess the association between serum levels of soluble IL-2 receptor (sIL-2r) and endothelin-1 and severe infection in children with Crimean-Congo hemorrhagic fever (CCHF). Fifty-two patients under 18 years of age with a laboratory- confirmed diagnosis of CCHF and 38 healthy controls were enrolled in the study. Patients were classified into two groups based on disease severity (severe group and non-severe group). The sIL-2r and endothelin-1 levels were observed to be significantly higher in patients with severe CCHF compared with those with non-severe CCHF and the control group (p < 0.05). In addition, those with non-severe CCHF were also found to have a significantly higher sIL-2r level relative to the control group (p < 0.001). Although there was a positive correlation between sIL-2r and endothelin-1 levels, serum levels of both sIL-2r and endothelin-1 were negatively correlated with the platelets count. In children with CCHF, serum levels of sIL-2r and endothelin-1 were increased, and this increase is related to the severity of the disease. In this study, we concluded through prognosis that serum levels of sIL-2r and endothelin-1 might be related, and that hemophagocytic lymphohistiocytosis and endothelial injury might contribute to a pathogenesis of the disease.<br /> (© 2013 APMIS. Published by John Wiley & Sons Ltd.)
- Subjects :
- Child
Child, Preschool
Female
Humans
Lymphocyte Activation immunology
Lymphohistiocytosis, Hemophagocytic pathology
Male
Platelet Activation immunology
Platelet Count
Prognosis
Turkey
Endothelin-1 blood
Hemorrhagic Fever, Crimean blood
Hemorrhagic Fever, Crimean immunology
Receptors, Interleukin-2 blood
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0463
- Volume :
- 122
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 24320760
- Full Text :
- https://doi.org/10.1111/apm.12209