1. Quantitative imaging for radiotherapy purposes
- Author
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Ben George, Kathrine Røe Redalen, Robert Julian, Oliver J. Gurney-Champion, Daniela Thorwarth, Marielle E.P. Philippens, Faisal Mahmood, Uulke A. van der Heide, and Marcel A van Schie
- Subjects
SUV, standard uptake value ,medicine.medical_specialty ,Quantitative imaging ,FDG, fluorodeoxyglucose ,medicine.medical_treatment ,ROI, region of interest ,QIBA, quantitative imaging biomarker alliance ,Review ,computer.software_genre ,Article ,QIB, quantitative imaging biomarker ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,ADC, apparent diffusion coefficient ,Voxel ,Multimodal imaging ,Multiparametric magnetic resonance imaging ,Radiation oncology ,Dose painting ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Multiparametric Magnetic Resonance Imaging ,Contouring ,Tumor ,medicine.diagnostic_test ,Radiotherapy ,business.industry ,DW-MRI, diffusion-weighted MRI ,Radiotherapy Planning, Computer-Assisted ,GTV, gross tumour volume ,Hematology ,SNR, signal-to-noise ratio ,Magnetic Resonance Imaging ,DCE, dynamic contrast-enhanced ,Radiation therapy ,Oncology ,Positron emission tomography ,030220 oncology & carcinogenesis ,Radiation Oncology ,STARD, standards for reporting of diagnostic accuracy ,Positron-emission tomography ,business ,computer ,QA, quality assurance ,Biomarkers - Abstract
Highlights • Quantitative imaging (QI) is promising for radiotherapy. • The key points from the QI track of the 2nd ESTRO Physics Workshop are discussed. • QI biomarkers may be used to assess the state of tumours throughout treatment. • Next steps for using QI in daily radiotherapy routine are identified. • QI biomarkers are mainly studied in exploratory studies; larger studies are desired., Quantitative imaging biomarkers show great potential for use in radiotherapy. Quantitative images based on microscopic tissue properties and tissue function can be used to improve contouring of the radiotherapy targets. Furthermore, quantitative imaging biomarkers might be used to predict treatment response for several treatment regimens and hence be used as a tool for treatment stratification, either to determine which treatment modality is most promising or to determine patient-specific radiation dose. Finally, patient-specific radiation doses can be further tailored to a tissue/voxel specific radiation dose when quantitative imaging is used for dose painting. In this review, published standards, guidelines and recommendations on quantitative imaging assessment using CT, PET and MRI are discussed. Furthermore, critical issues regarding the use of quantitative imaging for radiation oncology purposes and resultant pending research topics are identified.
- Published
- 2020