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Myelination may be impaired in neonates following birth asphyxia
- Source :
- NeuroImage : Clinical, NeuroImage: Clinical, Vol 31, Iss, Pp 102678-(2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Highlights • Myelination is a developmental process that intensifies after birth during the first years of life. • We used a T2* mapping sequence to assess myelination in healthy and critically ill neonates with neonatal encephalopathy. • Birth asphyxia, in addition to causing the previously well-described direct injury to the brain, may impair myelination.<br />Background Myelination is a developmental process that begins during the end of gestation, intensifies after birth over the first years of life, and continues well into adolescence. Any event leading to brain injury around the time of birth and during the perinatal period, such as birth asphyxia, may impair this critical process. Currently, the impact of such brain injury related to birth asphyxia on the myelination process is unknown. Objective To assess the myelination pattern over the first month of life in neonates with neonatal encephalopathy (NE) developing brain injury, compared to neonates without injury (i.e., healthy neonates and neonates with NE who do not develop brain injury). Methods Brain magnetic resonance imaging (MRI) was performed around day of life 2, 10, and 30 in healthy neonates and near-term/term neonates with NE who were treated with hypothermia. We evaluated myelination in various regions of interest using a T2* mapping sequence. In each region of interest, we compared the T2* values of the neonates with NE with brain injury to the values of the neonates without injury, according to the MRI timing, by using a repeated measures generalized linear mixed model. Results We obtained 74 MRI scans over the first month of life for 6 healthy neonates, 17 neonates with NE who were treated with hypothermia and did not develop brain injury, and 16 neonates with NE who were treated with hypothermia and developed brain injury. The T2* values significantly increased in the neonates with NE who developed injury in the posterior limbs of the internal capsule (day 2: p
- Subjects :
- Internal capsule
qMT, quantitative magnetisation transfer
Hypothermia
MWF, myelin water fraction
FOV, field of view
Myelination
0302 clinical medicine
Neonate
DTI, diffusion-tensor imaging
Pregnancy
MRT, magnetisation transfer ratio
MCR, multicomponent relaxation
Asphyxia Neonatorum
medicine.diagnostic_test
MWI, myelin water imaging
05 social sciences
McDESPOT, multi-component driven equilibrium single pulse observation of T1 and T2
NBI, no brain injury
SAR, specific absorption rate
Brain
Regular Article
SNR, signal-to-noise ratio
DOL, day of life
TR, repetition time
3. Good health
medicine.anatomical_structure
Neurology
Anesthesia
TSE, turbo spin echo
Hypoxia-Ischemia, Brain
Gestation
Female
NE, neonatal encephalopathy
medicine.symptom
Adolescent
Cognitive Neuroscience
Computer applications to medicine. Medical informatics
R858-859.7
Neonatal encephalopathy
050105 experimental psychology
MR, magnetic resonance
White matter
03 medical and health sciences
Asphyxia
Magnetic resonance imaging
BI, brain injury
medicine
Humans
0501 psychology and cognitive sciences
Radiology, Nuclear Medicine and imaging
RC346-429
business.industry
Infant, Newborn
Repeated measures design
ihMT, inhomogenous magnetisation transfer
medicine.disease
nervous system
PLIC, posterior limb of the internal capsule
TE, time to echo
Neurology. Diseases of the nervous system
Neurology (clinical)
business
SD, standard deviation
MRI, magnetic resonance imaging
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 22131582
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- NeuroImage : Clinical
- Accession number :
- edsair.doi.dedup.....97ca24ba198e3b3790437f4ce71c5069