1. CLA+ memory T cells in atopic dermatitis
- Author
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Nicolàs LSS, Czarnowicki T, Akdis M, Pujol RM, Lozano-Ojalvo D, Leung DYM, Guttman-Yassky E, and Santamaria-Babí LF
- Subjects
- Humans, Memory T Cells, T-Lymphocyte Subsets, Antigens, Differentiation, T-Lymphocyte, Membrane Glycoproteins, Receptors, Lymphocyte Homing, Skin pathology, Pruritus, Antigens, Neoplasm, Dermatitis, Atopic
- Abstract
Circulating skin-homing cutaneous lymphocyte-associated antigen (CLA)
+ T cells constitute a small subset of human memory T cells involved in several aspects of atopic dermatitis: Staphylococcus aureus related mechanisms, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL-13, IL-31, pruritus, CCL17 and early effects on dupilumab-treated patients have in common that they are associated with the CLA+ T cell mechanisms in atopic dermatitis patients. The function of CLA+ T cells corresponds with the role of T cells belonging to the skin-associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis and many other T cell mediated skin diseases. The goal of this review is to gather all this translational information of atopic dermatitis pathology., (© 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)- Published
- 2024
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