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IL-17 and CCR9
- Source :
- Frontiers in Immunology
- Publication Year :
- 2021
-
Abstract
- Previous studies have evaluated the roles of T and B cells in the pathogenesis of Sjögren’s syndrome (SS); however, their relationships with age-dependent and metabolic abnormalities remain unclear. We examined the impacts of changes associated with aging or metabolic abnormalities on populations of T and B cells and SS disease severity. We detected increased populations of IL-17-producing T and B cells, which regulate inflammation, in the salivary glands of NOD/ShiLtJ mice. Inflammation-induced human submandibular gland cell death, determined based on p-MLKL and RIPK3 expression levels, was significantly increased by IL-17 treatment. Among IL-17-expressing cells in the salivary gland, peripheral blood, and spleen, the α4β7 (gut-homing integrin)-negative population was significantly increased in aged NOD/ShiLtJ mice. The α4β7-positive population markedly increased in the intestines of aged NOD/ShiLtJ mice following retinoic acid (RA) treatment. A significant increase in α4β7-negative IL-17-expressing cells in salivary glands may be involved in the onset and progression of SS. These results suggest the potential therapeutic utility of RA in SS treatment.
- Subjects :
- Blood Glucose
Cell Death
Stem Cells
Interleukin-17
Immunology
aging
Receptors, Lymphocyte Homing
Salivary Glands
Disease Models, Animal
Mice
Receptors, CCR
Sjogren's Syndrome
Sjögren’s syndrome
retinoic acid
Animals
Th17 Cells
Disease Susceptibility
gut-homing
Cell Self Renewal
interleukin 17
Biomarkers
Original Research
Subjects
Details
- ISSN :
- 16643224
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in immunology
- Accession number :
- edsair.pmid..........693261fae146e7b43b9b3069e44bbe4d